CN112546306A - Multilayer medicine-carrying PLGA wire material, preparation method and application - Google Patents
Multilayer medicine-carrying PLGA wire material, preparation method and application Download PDFInfo
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- CN112546306A CN112546306A CN202011560414.1A CN202011560414A CN112546306A CN 112546306 A CN112546306 A CN 112546306A CN 202011560414 A CN202011560414 A CN 202011560414A CN 112546306 A CN112546306 A CN 112546306A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/22—Lipids, fatty acids, e.g. prostaglandins, oils, fats, waxes
- A61L2300/222—Steroids, e.g. corticosteroids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
- A61L2300/406—Antibiotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/43—Hormones, e.g. dexamethasone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
- A61L2300/608—Coatings having two or more layers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/08—Coatings comprising two or more layers
Abstract
A multilayer medicine-carrying PLGA wire material, a preparation method and application thereof belong to the field of medical materials. Firstly, preparing a PLGA solution; then uniformly dispersing the medicine into the PLGA solution to obtain a medicine-PLGA solution; then soaking the formed PLGA filaments into a drug-PLGA solution, taking out the PLGA filaments, and solidifying the PLGA filaments after the solvent is volatilized to form a surface coating to obtain a PLGA wire with a single-layer drug coating; and moving the composite material into a medicine-PLGA solution again, and repeating the steps to obtain the PLGA line material with multiple layers of medicine carrying. The material has good physical and chemical properties and biocompatibility, and the characteristics of multi-layer medicine loading enable the material to have higher medicine loading rate and longer medicine release period. The multilayer medicine-carrying PLGA thread is used as a base material, can construct a stent material with a net structure, a tubular structure and other controllable structures, and is used for clinically constructing tissue supporting and repairing materials such as a sinus stent, an airway stent, a urethral stent and the like.
Description
Technical Field
The invention belongs to the field of medical materials, relates to a multilayer medicine-carrying PLGA wire material and a preparation method thereof, and particularly relates to a method for preparing a medicine-carrying PLGA wire material with good physicochemical property and biocompatibility.
Background
For tissues and organs such as nasal sinuses, airways and urethra, the normal function of the tissues can be affected after stenosis occurs, and the health of human beings is seriously affected. Tissue patency can be improved to some extent by surgical treatment, but post-operative inflammatory reactions and restenosis often lead to organ dysfunction again. The degradable polymer stent material is implanted into the operation position to expand and strut the tissue channel, and corresponding drug molecules are introduced at the same time, so that the drug slow release process can be helpful for the repair and treatment of the postoperative tissue.
In view of the above, it is desirable to prepare a degradable polymer thread material capable of loading and slowly releasing drugs, and further construct a scaffold material having a mesh structure, a tubular structure and other controllable structures based on the thread material, so that the scaffold material can be applied to repair processes of different parts. The polylactic acid-glycolic acid copolymer (PLGA) is formed by randomly polymerizing lactic acid and glycolic acid, is a degradable functional polymer organic compound approved by the FDA in the United states, and has good biocompatibility and plasticity. The invention hopes to obtain the PLGA wire material with the multilayer medicine carrying characteristic by taking PLGA as a substrate material and carrying out multiple times of medicine coating treatment, thereby improving the medicine carrying capacity of the PLGA material and the slow release period of the medicine and further improving the repairing effect of the medicine carrying material in vivo. Meanwhile, aiming at patients with different degrees, PLGA wire materials and stent materials with different layers can be prepared in a targeted manner, so that personalized repair treatment is realized.
The obtained multilayer medicine-carrying PLGA wire material has good physical and chemical properties and biocompatibility, and the characteristics of multilayer medicine carrying enable the material to have higher medicine-carrying capacity and longer medicine-releasing period. Meanwhile, the multilayer medicine-carrying PLGA thread is taken as a base material, so that a stent material with a net structure, a tubular structure and other controllable structures can be further constructed, and the multilayer medicine-carrying PLGA thread can be applied to the research of clinically constructing tissue support materials such as sinus stents, airway stents, urethral stents and the like. The material has simple preparation process, controllable forming and simple equipment.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides a multilayer medicine-carrying PLGA wire material and a preparation method thereof.
The purpose of the invention is realized by the following technical scheme:
a multilayer medicine-carrying PLGA wire material and a preparation method thereof comprise the following steps:
(1) dissolving a PLGA raw material in a volatile solvent to prepare a PLGA solution with a certain concentration;
(2) adding the medicine solution into the PLGA solution obtained in the step (1), and fully stirring to uniformly disperse the medicine to obtain a medicine-PLGA solution with a certain concentration;
(3) soaking the formed PLGA filaments in the drug-PLGA solution obtained in the step (2), slowly taking out after soaking for a period of time, and solidifying to form a surface coating after volatilizable solvent is volatilized to obtain a PLGA wire with a single-layer drug coating;
(4) moving the PLGA line with the single-layer drug coating obtained in the step (3) to the drug-PLGA solution obtained in the step (2) again, and coating the drug-PLGA layer again for treatment to obtain the PLGA line with the double-layer drug coating;
(5) and (5) repeating the step in the step (4) for multiple times to obtain the PLGA thread material with multiple layers of medicine carrying.
Further, the concentration of the PLGA solution in the step (1) is 1.5-5.0%.
Further, the volatile solvent in step (1) is dichloromethane, chloroform, acetone or tetrahydrofuran.
Further, the mass concentration of the drug solution in the step (2) is 1.5-3.0%, and the mass ratio of the drug to the PLGA is 1: 1-1: 3.
Further, the drugs in the step (2) comprise mometasone furoate, gentamicin, steroid and hormone related drug molecules.
Further, the diameter of the PLGA filaments in the step (3) is 0.05-0.5 mm, and the coating of the PLGA filaments in the drug-PLGA solution in the steps (3) and (4) is soaked for 30 s.
Further, the medicine-loaded PLGA wire material in the step (5) is a PLGA material which is loaded with medicines by coating for multiple times, and the number of coating times of the medicines on the surface is 1-5 layers.
The PLGA drug-loaded thread material prepared by the method and various stent materials constructed by the PLGA drug-loaded thread material.
The invention has the beneficial effects that: the material obtained by the invention has better plasticity and the characteristic of multi-layer medicine carrying, so that the material has higher medicine carrying capacity and longer medicine release period. Meanwhile, the multilayer medicine-carrying PLGA thread is taken as a base material, so that a stent material with a net structure, a tubular structure and other controllable structures can be further constructed, and the multilayer medicine-carrying PLGA thread can be applied to the research of clinically constructing tissue support materials such as sinus stents, airway stents, urethral stents and the like. The material has simple preparation process, controllable forming and simple equipment.
Detailed Description
The invention will be further described with reference to the following examples for a better understanding of the invention, but the scope of the invention as claimed is not limited to the scope represented by the examples mentioned.
Example 1
PLGA and mometasone furoate are used as raw materials to prepare the PLGA wire material loaded with the multilayer mometasone furoate. The preparation steps of the multilayer medicine-carrying PLGA wire material are as follows:
(1) dissolving a PLGA raw material in dichloromethane, and preparing a PLGA solution with the mass concentration of 3%;
(2) adding mometasone furoate drug molecules into the PLGA solution obtained in the step (1), and fully stirring to uniformly disperse the drug to obtain a mometasone furoate solution with the mass concentration of 2.5%;
(3) soaking PLGA filaments with the diameter of 0.15mm into the medicine-PLGA solution obtained in the step (2), slowly taking out after soaking for 30s, and solidifying to form a mometasone furoate coating on the surface after the solvent is volatilized to obtain a PLGA wire material with a single mometasone furoate coating;
(4) moving the PLGA wire with the single-layer mometasone furoate coating obtained in the step (3) into a mometasone furoate solution with the concentration of 2.5% again, and carrying out drug loading treatment again to obtain a PLGA wire material with a double-layer drug coating;
(5) and (5) repeating the drug loading process in the step (4) again to obtain the PLGA thread material with three layers of mometasone furoate.
Example 2
PLGA and mometasone furoate are used as raw materials to prepare the PLGA mesh scaffold material loaded with the multilayer mometasone furoate. The preparation steps of the multilayer medicine-carrying PLGA reticular stent material are as follows:
(1) dissolving a PLGA raw material in dichloromethane, and preparing a PLGA solution with the mass concentration of 4.0%;
(2) adding mometasone furoate drug molecules into the PLGA solution obtained in the step (1), and fully stirring to uniformly disperse the drug to obtain a mometasone furoate solution with the mass concentration of 2.0%;
(3) soaking PLGA filaments with the diameter of 0.15mm into the medicine-PLGA solution obtained in the step (2), slowly taking out after soaking for 30s, and solidifying to form a mometasone furoate coating on the surface after the solvent is volatilized to obtain a PLGA wire material with a single mometasone furoate coating;
(4) moving the PLGA wire with the single-layer mometasone furoate coating obtained in the step (3) into a mometasone furoate solution with the concentration of 2.0% again, and carrying out drug loading treatment again to obtain a PLGA wire material with a double-layer drug coating;
(5) and (4) weaving the PLGA wire material with the double-layer drug coating obtained in the step (4) into a columnar stent material with a rhombic net structure.
Claims (9)
1. The preparation method of the multilayer medicine-carrying PLGA wire material is characterized by comprising the following steps:
(1) dissolving a PLGA raw material in a volatile solvent to prepare a PLGA solution with a certain concentration;
(2) adding the medicine solution into the PLGA solution obtained in the step (1), and fully stirring to uniformly disperse the medicine to obtain a medicine-PLGA solution with a certain concentration;
(3) soaking the formed PLGA filaments in the drug-PLGA solution obtained in the step (2), slowly taking out after soaking for a period of time, and solidifying to form a surface coating after volatilizable solvent is volatilized to obtain a PLGA wire with a single-layer drug coating;
(4) moving the PLGA line with the single-layer drug coating obtained in the step (3) to the drug-PLGA solution obtained in the step (2) again, and coating the drug-PLGA layer again for treatment to obtain the PLGA line with the double-layer drug coating;
(5) and (5) repeating the step in the step (4) for multiple times to obtain the PLGA thread material with multiple layers of medicine carrying.
2. The method according to claim 1, wherein the concentration of the PLGA solution in step (1) is 1.5 to 5.0% by mass.
3. The method according to claim 1, wherein the volatilizable solvent in step (1) is dichloromethane, chloroform, acetone or tetrahydrofuran.
4. The preparation method according to claim 1, wherein the mass concentration of the drug solution in the step (2) is 1.5-3.0%, and the mass ratio of the drug to the PLGA is 1: 1-1: 3.
5. The method of claim 1, wherein the drug of step (2) comprises mometasone furoate, gentamicin and/or a steroid.
6. The method according to claim 1, wherein the diameter of the PLGA filaments in step (3) is 0.05-0.5 mm, and the soaking time of the PLGA filaments in the drug-PLGA solution in the coating layers in steps (3) and (4) is 30 s.
7. A multilayer medicine-carrying PLGA wire material is characterized in that the multilayer medicine-carrying PLGA wire material is prepared by the preparation method of any one of claims 1 to 6, and is a PLGA material carrying medicine by coating for multiple times, and the number of the coating times of the surface medicine is 1-5.
8. The application of the multilayer medicine-carrying PLGA wire material prepared by the preparation method of any one of claims 1 to 6, wherein the multilayer medicine-carrying PLGA wire material is used for constructing various stent materials.
9. The use of claim 8, wherein said stent materials are in the form of a mesh stent structure or a tubular stent structure.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011560414.1A CN112546306A (en) | 2020-12-25 | 2020-12-25 | Multilayer medicine-carrying PLGA wire material, preparation method and application |
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| CN202011560414.1A CN112546306A (en) | 2020-12-25 | 2020-12-25 | Multilayer medicine-carrying PLGA wire material, preparation method and application |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1367023A (en) * | 2002-03-08 | 2002-09-04 | 清华大学 | Preparation method of biodegradable medicine composite macromolecular scaffold material |
| CN101234201A (en) * | 2008-01-24 | 2008-08-06 | 上海交通大学 | High molecule impregnation implantation sustained-release drug delivering system and preparation thereof |
| US20090155326A1 (en) * | 2007-11-12 | 2009-06-18 | Mack Brendan C | Layered drug delivery polymer monofilament fibers |
| CN102210616A (en) * | 2010-04-09 | 2011-10-12 | 乐普（北京）医疗器械股份有限公司 | Completely degradable polymer medicine elution stent and preparation method thereof |
| CN102727946A (en) * | 2012-02-10 | 2012-10-17 | 东华大学 | Drug loaded coating and its preparation method |
| CN106581752A (en) * | 2017-01-23 | 2017-04-26 | 苏州大学 | Degradable medicine slow release function composite enteric stent and making method thereof |
-
2020
- 2020-12-25 CN CN202011560414.1A patent/CN112546306A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1367023A (en) * | 2002-03-08 | 2002-09-04 | 清华大学 | Preparation method of biodegradable medicine composite macromolecular scaffold material |
| US20090155326A1 (en) * | 2007-11-12 | 2009-06-18 | Mack Brendan C | Layered drug delivery polymer monofilament fibers |
| CN101234201A (en) * | 2008-01-24 | 2008-08-06 | 上海交通大学 | High molecule impregnation implantation sustained-release drug delivering system and preparation thereof |
| CN102210616A (en) * | 2010-04-09 | 2011-10-12 | 乐普（北京）医疗器械股份有限公司 | Completely degradable polymer medicine elution stent and preparation method thereof |
| CN102727946A (en) * | 2012-02-10 | 2012-10-17 | 东华大学 | Drug loaded coating and its preparation method |
| CN106581752A (en) * | 2017-01-23 | 2017-04-26 | 苏州大学 | Degradable medicine slow release function composite enteric stent and making method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 赵志河等: "《口腔力学生物学》", 31 December 2017 * |
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