CN112545917A - 一种消毒凝胶及其制备方法 - Google Patents
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Abstract
本发明公开了一种消毒凝胶及其制备方法,以重量计算包括以下制备原料:壳聚糖盐酸盐0.05~0.3%,甘草次酸0.01~0.05%,乙醇30~80%,增稠剂0.1~1%,保湿剂1.0~5.0%,pH调节剂0.1~1%,泛醇0.1~0.3%,香精0.1~0.2%,余量的去离子水。本发明以壳聚糖盐酸盐、甘草次酸和乙醇作为清洁防腐杀菌剂,起到快速杀菌和长久杀菌抑菌的作用;通过增稠剂、保湿剂和pH调节剂的添加,提高凝胶性能。配方合理,性能稳定,使用方便,手感佳,具有良好的杀菌的效果,且不伤害皮肤,无潜在健康风险,同时可发挥速效、长效的特点,克服了单组方消毒剂的缺点,同时兼具护肤作用。
Description
技术领域
本发明涉及消毒凝胶领域,尤其涉及一种消毒凝胶及其制备方法。
背景技术
ARS相关冠状病毒、乙肝病毒、HIV等高致病病毒威胁着人类的生命与健康,许多疾病都与致病微生物感染相关,手是病毒、病菌传播的重要途径,洗手消毒可预防病毒、病菌的传播,维护人类健康,免洗手消毒需更有效、更方便。
目前市场上消毒产品种类繁多,其中:碘和含碘制剂是被临床广泛应用的皮肤消毒剂。临床常用的含碘制剂主要是碘配,碘水和聚维酮碘。聚维酮碘是当前最主要的含碘皮肤消毒剂,是碘与表面活性剂结合而成的不定型络合物。但是碘制剂的颜色及成本限制了在日常生活中的应用。84消毒剂、过氧乙酸消毒都对病毒有杀灭作用,但对皮肤有腐蚀性,不能用于皮肤消毒,其它消毒产品对病毒无明确杀灭作用。
因此,如何达到在杀菌率高的同时减少消毒剂的副作用,同时使消费者使用起来不粘腻、气味舒适且护肤效果好,需要杀菌谱广、杀菌效果好、手感清爽、刺激性小,这是一个亟待解决的问题。
壳聚糖及其衍生物有较好的抗菌活性,能抑制一些真菌、细菌、和病毒的生长繁殖。目前认为其可能的机制有三:一是由于壳聚糖的多聚阳离子,易于真菌细胞表面带负电荷的基团作用,从而改变病原菌细胞膜的流动性和通透性;二是干扰DNA的复制与转录;三是阻断病原菌代谢。近年来,有许多研究者提出壳聚糖通过诱导病程相关蛋白,积累次生代谢产物和信号传导等方式来达到抗菌的目的的观点。
但是目前将其应用于消毒凝胶中去尚无报道。
发明内容
发明目的:为了克服现有技术中存在的问题,本发明提出了一种使用方便,手感好,杀菌效果好的消毒凝胶及其制备方法。
技术方案:为了解决上述技术问题,本发明所采用的技术方案为:
壳聚糖盐酸盐0.05~0.3%,甘草次酸0.01~0.05%,乙醇30~80%,增稠剂0.1~1%,保湿剂1.0~5.0%,pH调节剂0.1~1%,泛醇0.1~0.3%,香精0.1~0.2%,余量的去离子水。
作为配方的进一步改进,一种消毒凝胶,以重量计算包括以下制备原料:壳聚糖盐酸盐0.2%,甘草次酸0.04%,乙醇65%,增稠剂0.3%,保湿剂1.0%,pH调节剂0.3%,泛醇0.25%,香精0.1%,余量的去离子水。
更进一步的,所述增稠剂为卡波姆、聚丙烯酸类聚合物、明胶、羟乙基纤维素中的一种或多种。
更进一步的,所述保湿剂为甘油、丙二醇中的一种或两种。
更进一步的,所述pH调节剂为三乙醇胺、异丁醇胺中的一种或两种。
本发明还公开了上述消毒凝胶的制备方法,包括如下步骤:
(1)称取壳聚糖盐酸盐,将其加入去离子水中搅拌至完全溶解;
(2)称取增稠剂,将其加入壳聚糖盐酸盐溶液中溶胀;得到a液;
(3)称取甘草次酸、香精,将其溶解于乙醇溶液中,搅拌均匀;得到b液;
(4)称取保湿剂、泛醇,将其加入a液中;之后,再加入b液;搅拌均匀后,再加入pH调节剂,以形成凝胶;搅拌后得到消毒凝胶。
有益效果:
(1)本发明以壳聚糖盐酸盐、甘草次酸和乙醇作为清洁防腐杀菌剂,起到快速杀菌和长久杀菌抑菌的作用;
(2)通过增稠剂、保湿剂和pH调节剂的添加,提高凝胶性能。
(3)配方合理,性能稳定,使用方便,手感佳,具有良好的杀菌的效果,且不伤害皮肤,无潜在健康风险,同时可发挥速效、长效的特点,克服了单组方消毒剂的缺点,同时兼具护肤作用。
(4)本发明采用的天然来源的壳聚糖主要抑菌作用针对有有细胞结构的病原微生物,对于病毒类非细胞结构的病原微生物,甘草次酸可以加强壳聚糖对细胞膜的破坏作用。两者复配,提高产品的抗菌效能,具有协同作用。
具体实施方式
下面结合实施例对本发明作进一步的详细说明:
实施例1:
一种消毒凝胶,以重量计算包括下述组份:壳聚糖盐酸盐0.05%,甘草次酸0.02%,乙醇50%,增稠剂0.3%,保湿剂1.0%,pH调节剂0.3%,泛醇0.1%,香精0.1%,余量的去离子水。
其中乙醇为体积分数为95%的食用酒精;增稠剂为卡波姆940;保湿剂为甘油;pH调节剂为三乙醇胺。
上述消毒凝胶的制备方法,包括以下步骤:
(1)称取壳聚糖盐酸盐,将其加入去离子水中搅拌至完全溶解;
(2)称取增稠剂,将其加入壳聚糖盐酸盐溶液中溶胀;得到a液;
(3)称取甘草次酸、香精,将其溶解于乙醇溶液中,搅拌均匀;得到b液;
(4)称取保湿剂、泛醇,将其加入a液中;之后,再加入b液;搅拌均匀后,再加入pH调节剂,以形成凝胶;搅拌后得到消毒凝胶。
实施例2:
一种消毒凝胶,以重量计算包括下述组份:壳聚糖盐酸盐0.15%,甘草次酸0.035%,乙醇65%,增稠剂0.4%,保湿剂3%,pH调节剂0.4%,泛醇0.2%,香精0.1%,余量的去离子水。
其中乙醇为体积分数为95%的食用酒精;增稠剂为卡波姆U20;保湿剂为丙二醇;pH调节剂为三乙醇胺。
制备方法与实施例1相同。
实施例3:
一种消毒凝胶,以重量计算包括下述组份:壳聚糖盐酸盐0.3%,甘草次酸0.05%,乙醇75%,增稠剂0.3%,保湿剂5%,pH调节剂0.3%,泛醇0.3%,香精0.1%,余量的去离子水。
其中乙醇为体积分数为95%的食用酒精;增稠剂为卡波姆941;保湿剂为丙二醇;pH调节剂为三乙醇胺。
制备方法与实施例1相同。
实施例4:
一种消毒凝胶,以重量计算包括下述组份:壳聚糖盐酸盐0.2%,甘草次酸0.04%,乙醇65%,增稠剂0.3%,保湿剂1.0%,pH调节剂0.3%,泛醇0.25%,香精0.1%,余量的去离子水。
其中乙醇为体积分数为95%的食用酒精;增稠剂为卡波姆U20;保湿剂为甘油;pH调节剂为三乙醇胺。
制备方法与实施例1相同。
对比例1:
一种不含甘草次酸,只消毒凝胶,以重量计算包括以下制备原料:
壳聚糖盐酸盐0.2%,乙醇55%,增稠剂0.3%,保湿剂1.0%,pH调节剂0.3%,泛醇0.25%,香精0.1%,余量的去离子水。
除去甘草次酸的加入,其他制备方法与实施例1相同。
一、性能测试:
1)将待测菌落,包括大肠杆菌、金黄色葡萄球菌、白色念珠菌,用灭菌处理后的磷酸盐缓冲液配制成菌悬液。取2.0cm×3.0cm大小的被试样片和对照样片各4片,被试样片用消毒凝胶浸润,对照样片与试样同质材料,同等大小,但不含抗菌材料,且经灭菌处理,将被试样片和对照样片分成4组置于4个灭菌平皿内。取上述菌悬液,分别在每个被试样片和对照样片上滴加10μL,均匀涂布,开始计时,作用1min,用无菌镊分别将样片投入含5mL相应中和剂的试管内,充分混匀,作适当稀释,然后取其中2~3个稀释度,分别吸取1mL,置于两个平皿,用凉至40~45℃的营养琼脂培养基或沙氏琼脂培养基15mL作倾注,转动平皿,使其充分均匀,琼脂凝固后翻转平板,大肠杆菌、金黄色葡萄球菌在35℃±2℃培养24h,白色念珠菌35℃±2℃培养48h,作活菌菌落计数,并计算杀灭对数值。
分别测试实施例4以及对比例1组对大肠杆菌、金黄色葡萄球菌、白色念珠菌的杀菌效果。实验条件为:作用时间2min;作用浓度100%;结果如下表所示:
大肠杆菌检测结果
金黄色葡萄球菌检测结果
白色念珠菌检测结果
由上表可见,本发明的消毒凝胶对于大肠杆菌、金黄色葡萄球菌、白色念珠菌均具有良好的杀菌抑菌效果;尤其是与对比例1相比,协同甘草次酸的复配作用相比,且杀菌抑菌效果更佳。
应当指出,以上具体实施方式仅用于说明本发明而不用于限制本发明的范围,在阅读了本发明之后,本领域技术人员对本发明的各种等价形式的修改均落于本申请所附权利要求所限定的范围。
Claims (6)
1.一种消毒凝胶,其特征在于以重量计算包括以下制备原料:壳聚糖盐酸盐0.05~0.3%,甘草次酸0.01~0.05%,乙醇30~80%,增稠剂0.1~1%,保湿剂1.0~5.0%,pH调节剂0.1~1%,泛醇0.1~0.3%,香精0.1~0.2%,余量的去离子水。
2.根据权利要求1所述的消毒凝胶,其特征在于以重量计算包括以下制备原料:壳聚糖盐酸盐0.2%,甘草次酸0.04%,乙醇65%,增稠剂0.3%,保湿剂1.0%,pH调节剂0.3%,泛醇0.25%,香精0.1%,余量的去离子水。
3.根据权利要求1或2所述的消毒凝胶,其特征在于:所述增稠剂为卡波姆、聚丙烯酸类聚合物、明胶、羟乙基纤维素中的一种或多种。
4.根据权利要求1或2所述的消毒凝胶,其特征在于:所述保湿剂为甘油、丙二醇中的一种或两种。
5.根据权利要求1或2所述的消毒凝胶,其特征在于:所述pH调节剂为三乙醇胺、异丁醇胺中的一种或两种。
6.一种权利要求1所述的消毒凝胶的制备方法,其特征在于包括如下步骤:
(1)称取壳聚糖盐酸盐,将其加入去离子水中搅拌至完全溶解;
(2)称取增稠剂,将其加入壳聚糖盐酸盐溶液中溶胀;得到a液;
(3)称取甘草次酸、香精,将其溶解于乙醇溶液中,搅拌均匀;得到b液;
(4)称取保湿剂、泛醇,将其加入a液中;之后,再加入b液;搅拌均匀后,再加入pH调节剂,以形成凝胶;搅拌后得到消毒凝胶。
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CN117442778A (zh) * | 2023-11-20 | 2024-01-26 | 美闺(长沙)医疗美容有限公司 | 一种用于医疗美容的凝胶组合物 |
CN117442778B (zh) * | 2023-11-20 | 2024-05-10 | 美闺(长沙)医疗美容有限公司 | 一种用于医疗美容的凝胶组合物 |
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