CN112540173A - Sample adding device and auxiliary sample adding type test structure - Google Patents

Sample adding device and auxiliary sample adding type test structure Download PDF

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Publication number
CN112540173A
CN112540173A CN202011389630.4A CN202011389630A CN112540173A CN 112540173 A CN112540173 A CN 112540173A CN 202011389630 A CN202011389630 A CN 202011389630A CN 112540173 A CN112540173 A CN 112540173A
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China
Prior art keywords
swab
sample
groove
test card
sample adding
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Pending
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CN202011389630.4A
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Chinese (zh)
Inventor
林学祥
施凯升
颜小惠
秦爱清
曾雨辉
肖鑫
宋文静
吴婷婷
陈圆园
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RGI (FUZHOU) GENETIC MEDICINE LABORATORY Co.,Ltd.
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Cellex Biological Technology Suzhou Co ltd
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Priority to CN202011389630.4A priority Critical patent/CN112540173A/en
Publication of CN112540173A publication Critical patent/CN112540173A/en
Pending legal-status Critical Current

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/558Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

The invention relates to an auxiliary loading type test structure, which comprises a test card and a loading device matched with the test card for use, wherein the loading device comprises a loading block, a loading gap is formed in the loading block, the loading gap comprises a loading slope, a diluting liquid tank is formed in the bottom of the loading gap on the inner side of the loading block, a sealing film is arranged at the bottom of the diluting liquid tank, a test card pushing groove is formed in the lower end of the loading block, and after the test card is pushed in, a detection sample dropping groove on the test card is overlapped with the diluting liquid tank; a swab leading-in groove communicated with the dilution liquid groove is formed in the Y-axis direction of the sample adding slope, the swab leading-in groove is arranged in an inclined downward mode, a swab moves downward through the swab leading-in groove, and a swab cotton swab part reaches a sample pad of the test card; during testing, the swab is fully stirred and diluted in the dilution liquid tank, then the sealing film at the bottom of the sealed dilution tank is downwards pierced through the guide of the swab introduction tank, the swab cotton swab part is contacted with the sample pad of the test card, and the dilution liquid also falls into the sample pad card to be tested.

Description

Sample adding device and auxiliary sample adding type test structure
Technical Field
The invention relates to the technical field of medical supplies, in particular to a medical testing tool, and particularly shows a sample adding device and an auxiliary sample adding type testing structure.
Background
The test card box is used for detecting pathogens in the medical field, a cotton swab is used for dipping the test pathogens, then the test pathogens are diluted by a diluent, and a test strip is used for testing.
The use process of the test card box used at present has the following points that need to be improved:
for instance, when a new coronary pneumonia test is carried out, a dropper-equipped extraction tube is required to rinse a sample swab dipped with a sample. When in use, the extraction tube cover is firstly opened, the swab is immersed into the diluent in the tube for sufficient rinsing, then the swab is broken off, and the tube cover of the extraction tube is screwed up. Then, the cover in front of the dropper needs to be opened, the extraction tube is inverted, and the swab moistening and washing liquid is dripped onto the detection card through the dripper on the cover, so that the whole process is complicated. Furthermore, sufficient rinsing requires a large amount of diluent, and a part of the diluent mixed with the sample remains in the extraction tube and the swab and does not reach the detection card, resulting in a loss of detection sensitivity.
Therefore, it is necessary to provide a sample adding device and an auxiliary sample adding type test structure to solve the above problems.
Disclosure of Invention
The invention aims to provide a sample adding device and an auxiliary sample adding type test structure, wherein the step of breaking a swab is omitted during use, and the sample adding device is arranged and comprises a bottom sealed dilution liquid tank; the addition of the diluent can be controlled by the size of the diluent groove, meanwhile, as the cotton swab part of the swab is contacted with the sample pad, the diluent amount of the cotton swab volume can be correspondingly reduced, and the liquid brought by the contact of the cotton swab and the sample pad is also partially infiltrated into the sample pad, so that the concentration of the detected protomer in the diluent is improved to a certain extent, and the test precision is improved; the design is simple and convenient, can directly arrange with current detection card, and the operation process has saved multinomial operation step, and liquid can be more on liquid in the groove and the swab on can be more through capillary infiltration effect on being absorbed the sample pad that detects the card, and more samples reach and detect the effective sensitivity that improves of card.
The first technical scheme is as follows:
the utility model provides a loading device, includes the application of sample piece, has seted up the application of sample breach on the application of sample piece, and the application of sample breach includes the application of sample slope, and dilution cistern has been seted up to the application of sample breach in the bottom of application of sample piece inside, and dilution cistern bottom is provided with the seal membrane, and the application of sample piece lower extreme has been seted up test card push-in groove, and after the test card pushes in, detection sample dropping groove and dilution cistern coincidence on the test card.
Furthermore, the bottom of the sample adding block is hollowed.
Furthermore, a swab leading-in groove communicated with the dilution liquid groove is formed in the Y-axis direction of the sample adding slope, the swab leading-in groove is arranged obliquely downwards, the swab moves downwards backwards through the swab leading-in groove, and the swab and swab portion reaches the sample pad of the test card.
Further, a swab diluting and stirring inlet groove is arranged at the bottom of the X-axis of the sample adding slope.
The second technical scheme is as follows:
an auxiliary sample adding type test structure comprises a test card and a sample adding device matched with the test card for use, wherein the sample adding device comprises a sample adding block, a sample adding notch is formed in the sample adding block, the sample adding notch comprises a sample adding slope, a diluting liquid tank is formed in the bottom of the sample adding notch on the inner side of the sample adding block, a sealing film is arranged at the bottom of the diluting liquid tank, a test card pushing groove is formed in the lower end of the sample adding block, and after the test card is pushed in, a detection sample dropping groove in the test card is overlapped with the diluting liquid tank; a swab leading-in groove communicated with the dilution liquid groove is formed in the Y-axis direction of the sample adding slope, the swab leading-in groove is arranged in an inclined downward mode, a swab moves downward through the swab leading-in groove, and a swab cotton swab part reaches a sample pad of the test card; during the test, the swab is stirred and diluted fully in advance of the dilution liquid tank, then the sealing film at the bottom of the sealed dilution tank is penetrated downwards through the guide of the swab introduction tank, then the swab cotton swab part of the swab contacts the sample pad of the test card, and the dilution liquid also falls into the sample pad card to be tested, so that an auxiliary addition type test structure is formed.
Furthermore, the bottom of the sample adding block is hollowed.
Further, a swab diluting and stirring inlet groove is arranged at the bottom of the X-axis of the sample adding slope.
Compared with the prior art, the method omits the step of breaking the swab when in use, and the sample adding device is arranged and comprises the dilution liquid tank with the sealed bottom; the addition of the diluent can be controlled by the size of the diluent groove, meanwhile, as the cotton swab part of the swab is contacted with the sample pad, the diluent amount of the cotton swab volume can be correspondingly reduced, and the liquid brought by the contact of the cotton swab and the sample pad is also partially infiltrated into the sample pad, so that the concentration of the detected protomer in the diluent is improved to a certain extent, and the test precision is improved; the design is simple and convenient, can directly arrange with current detection card, and the operation process has saved multinomial operation step, and liquid in the inslot liquid and on the swab can be more through capillary infiltration effect on being absorbed the sample pad that detects the card, more samples reachs the detection card moreover.
Drawings
FIG. 1 is a schematic diagram of the present invention.
FIG. 2 is a second schematic structural diagram of the present invention.
Fig. 3 is a third schematic structural diagram of the present invention.
Detailed Description
Example (b):
referring to fig. 1 to fig. 3, the present embodiment shows an auxiliary sample-adding type test structure, which includes a test card 100 and a sample-adding device 200 used in cooperation with the test card 100.
The sample adding device 200 comprises a sample adding block 1, a sample adding notch 2 is formed in the sample adding block 1, the sample adding notch 2 comprises a sample adding slope 3, a diluting liquid tank 4 is formed in the bottom of the inner side of the sample adding block 1 through the sample adding notch 2, a sealing film 5 is arranged at the bottom of the diluting liquid tank 4, a test card pushing tank 31 is formed in the lower end of the sample adding block 1, and after the test card 100 is pushed, the test card 100 detects coincidence of a sample dropping tank 101 and the diluting liquid tank 4.
The Y-axis of the sample-adding slope 3 is provided with a swab introduction groove 32 communicated with the dilution liquid groove 4, the swab introduction groove 32 is arranged obliquely downwards, the swab 300 moves downwards through the swab introduction groove 32, and the swab part 301 reaches the sample pad of the test card 100.
During testing, the swab 300 is fully stirred and diluted in the dilution liquid tank 4, and then guided by the swab introduction tank 31 to movably puncture the sealing film at the bottom of the sealed dilution tank 4, and then the swab cotton swab part 301 of the swab 300 contacts the sample pad of the test card 100, so that the dilution liquid falls into the sample pad card to be tested, and an auxiliary pattern adding test structure is formed.
Wherein:
the sealing film 5 is formed by a film which is heat-sealed at the bottom of the dilution liquid tank;
the bottom of the sample adding block is hollowed.
Simultaneously, the entering mode during swab stirring and dilution can be specifically as follows:
the bottom of the sample-adding slope 3 in the X-axis direction is provided with a swab diluting and stirring inlet groove 33.
The present embodiment can be applied to the following test scenarios:
new coronary pneumonia test: a tester firstly uses the swab 300 to extract a test body, and the swab 300 with the test body on the swab part 301 is obtained; the swab 300 is sufficiently stirred and diluted in the dilution liquid tank 4, and then guided by the swab introduction tank 31 to penetrate the sealing film 5 at the bottom of the dilution liquid tank 4, and then the swab cotton tip part 301 of the swab 300 contacts the sample pad of the test card 100, so that the dilution liquid falls into the sample pad card for testing, and the test result is obtained by reading the test card.
Compared with the prior art, the step of breaking the swab is omitted when the test device is used, the sample adding device comprises the dilution tank with the sealed bottom, the swab is fully stirred and diluted before the dilution tank during testing, the sealing film at the bottom of the dilution tank is punctured downwards, then the cotton swab part of the swab is contacted with the sample pad of the test card, the dilution liquid falls into the sample pad card for testing, and the test efficiency is effectively improved; the addition of the diluent can be controlled by the size of the diluent groove, meanwhile, as the cotton swab part of the swab is contacted with the sample pad, the diluent amount of the cotton swab volume can be correspondingly reduced, and the liquid brought by the contact of the cotton swab and the sample pad is also partially infiltrated into the sample pad, so that the concentration of the detected protomer in the diluent is improved to a certain extent, and the test precision is improved; the design is simple and convenient, can directly arrange with current detection card, and the operation process has saved multinomial operation step, and liquid in the inslot liquid and on the swab can be more through capillary infiltration effect on being absorbed the sample pad that detects the card, more samples reachs the detection card moreover.
What has been described above are merely some embodiments of the present invention. It will be apparent to those skilled in the art that various changes and modifications can be made without departing from the inventive concept thereof, and these changes and modifications can be made without departing from the spirit and scope of the invention.

Claims (5)

1. A sample application device, comprising: including adding the appearance piece, having seted up the application of sample breach on adding the appearance piece, the application of sample breach includes the application of sample slope, and the dilution cistern has been seted up to the application of sample breach in the bottom of application of sample piece inside, and dilution cistern bottom is provided with the seal membrane, and test card pushin groove has been seted up to application of sample piece lower extreme, and the test card pushes in the back, and detection sample on the test card drips groove and the coincidence of dilution cistern.
2. The sample adding device according to claim 1, wherein: the Y axial of application of sample slope is seted up the swab lead-in groove of intercommunication dilution cistern, and the swab lead-in groove is the slant and sets up down, and the swab passes through the downward back activity of swab lead-in groove, and the sample pad of test card is arrived to swab cotton swab portion.
3. The sample adding device according to claim 2, wherein: and a swab diluting and stirring inlet groove is formed in the bottom of the X axis of the sample adding slope.
4. The utility model provides an auxiliary adding style test structure which characterized in that: the device comprises a test card and a sample adding device matched with the test card for use, wherein the sample adding device comprises a sample adding block, a sample adding notch is formed in the sample adding block, the sample adding notch comprises a sample adding slope, a diluting liquid tank is formed in the bottom of the sample adding notch on the inner side of the sample adding block, a sealing film is arranged at the bottom of the diluting liquid tank, a test card push-in groove is formed in the lower end of the sample adding block, and after the test card is pushed in, a detection sample dropping groove in the test card is overlapped with the; a swab leading-in groove communicated with the dilution liquid groove is formed in the Y-axis direction of the sample adding slope, the swab leading-in groove is arranged in an inclined downward mode, a swab moves downward through the swab leading-in groove, and a swab cotton swab part reaches a sample pad of the test card; during the test, the swab is stirred and diluted fully in advance of the dilution liquid tank, then the sealing film at the bottom of the sealed dilution tank is penetrated downwards through the guide of the swab introduction tank, then the swab cotton swab part of the swab contacts the sample pad of the test card, and the dilution liquid also falls into the sample pad card to be tested, so that an auxiliary addition type test structure is formed.
5. An auxiliary patterning test structure according to claim 4, wherein: and a swab diluting and stirring inlet groove is formed in the bottom of the X axis of the sample adding slope.
CN202011389630.4A 2020-12-02 2020-12-02 Sample adding device and auxiliary sample adding type test structure Pending CN112540173A (en)

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CN202011389630.4A CN112540173A (en) 2020-12-02 2020-12-02 Sample adding device and auxiliary sample adding type test structure

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Application Number Priority Date Filing Date Title
CN202011389630.4A CN112540173A (en) 2020-12-02 2020-12-02 Sample adding device and auxiliary sample adding type test structure

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023277403A1 (en) * 2021-06-29 2023-01-05 광주과학기술원 Point of care membrane diagnosis sensor

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US20010034068A1 (en) * 1998-07-14 2001-10-25 Spivey Robin James Screening device and methods of screening immunoassay tests and agglutination tests
CN1509409A (en) * 2001-05-18 2004-06-30 ����ʵ�鼼����˾ In-line test device and methods of use
JP2010038797A (en) * 2008-08-06 2010-02-18 Sumitomo Bakelite Co Ltd Container for specimen picking and inspection kit
US20110318755A1 (en) * 2008-12-15 2011-12-29 Piasio Roger N Universal Testing Platform for Medical Diagnostics
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Publication number Priority date Publication date Assignee Title
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