CN112516947A - Medicine midbody reation kettle for drug synthesis - Google Patents
Medicine midbody reation kettle for drug synthesis Download PDFInfo
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- CN112516947A CN112516947A CN202011404583.6A CN202011404583A CN112516947A CN 112516947 A CN112516947 A CN 112516947A CN 202011404583 A CN202011404583 A CN 202011404583A CN 112516947 A CN112516947 A CN 112516947A
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- partition plate
- reaction kettle
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/18—Stationary reactors having moving elements inside
- B01J19/1862—Stationary reactors having moving elements inside placed in series
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0006—Controlling or regulating processes
- B01J19/0013—Controlling the temperature of the process
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0053—Details of the reactor
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/08—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
- B01J19/12—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing electromagnetic waves
- B01J19/122—Incoherent waves
Abstract
The invention discloses a drug intermediate reaction kettle for drug synthesis.A support column is arranged in a stirring layer, and the upper end and the lower end of the support column are respectively communicated with the upper end and the lower end of an adjusting layer; a first partition plate is arranged on the inner side surface of the reaction kettle and the outer side surface of the partition plate, the first partition plate divides the adjusting layer into an upper part and a lower part, and the first partition plate can move up and down on the inner side surface of the reaction kettle and the outer side surface of the partition plate; a telescopic rod which can stretch up and down along the vertical direction is arranged in the supporting column, the upper end of the telescopic rod is connected with a second partition plate, and the second partition plate divides the inside of the supporting column into an upper part and a lower part; the lower part of adjusting layer and the lower part of support column are filled with the second liquid, and the upper part of adjusting layer and the upper part of support column are filled with first liquid. The device can be suitable for drug synthesis reaction under different temperature conditions, and has higher use efficiency.
Description
Technical Field
The invention relates to a reaction kettle, in particular to a drug intermediate reaction kettle for drug synthesis.
Background
The reaction kettle is widely applied to pressure vessels for petroleum, chemical engineering, rubber, pesticides, dyes, medicines and foods, and is used for completing technological processes such as vulcanization, nitration, hydrogenation, alkylation, polymerization, condensation and the like, such as a reactor, a reaction kettle, a decomposition kettle, a polymerization kettle and the like; the material is generally carbon manganese steel, stainless steel, zirconium, nickel-based (Hastelloy, Monel, Inconel) alloy and other composite materials.
The general understanding of the reaction kettle is that a stainless steel container with physical or chemical reaction is subjected to structural design and parameter configuration according to different process condition requirements, and the design conditions, the process, the inspection, the manufacture and the acceptance are required to be based on related technical standards so as to realize the heating, evaporation, cooling and low-speed mixing reaction functions required by the process.
The preparation of the drug is a complicated process, and the preparation methods of the drug are different along with the difference of the drug mechanism, and the different preparation methods can influence the quality of the finally obtained drug.
The conventional medicine reaction kettle is single in structure, can only be used for a certain specific preparation process generally, is complex in structure, needs to be completely disassembled when the reaction kettle needs to be replaced and maintained, then replaces internal parts, or needs to be directly replaced, and is low in use efficiency. And the reaction parameters of the reaction kettle are set, certain parameters cannot be adjusted according to different medicines, and the reaction kettle is inconvenient to be widely used for a long time.
Disclosure of Invention
The invention aims to provide a drug intermediate reaction kettle for drug synthesis, which heats the bottom and the inside of the reaction kettle through a second liquid, can heat the second liquid to different temperatures, cools the upper part and the inside of the reaction kettle through a first liquid, can cool the first liquid to different temperatures, does not refrigerate when reacting at normal temperature, and can also be used as a heat dissipation liquid to dissipate heat of the reaction kettle.
The purpose is realized by adopting the following technical scheme:
the device comprises a reaction kettle, wherein a partition plate is arranged in the reaction kettle, the partition plate divides the reaction kettle into a stirring layer and an adjusting layer from inside to outside in sequence, a support column is arranged in the stirring layer, and the upper end and the lower end of the support column are respectively communicated with the upper end and the lower end of the adjusting layer; a first partition plate is arranged on the inner side surface of the reaction kettle and the outer side surface of the partition plate, the first partition plate divides the adjusting layer into an upper part and a lower part, and the first partition plate can move up and down on the inner side surface of the reaction kettle and the outer side surface of the partition plate; the support column is provided with a telescopic rod which can stretch up and down along the vertical direction, the lower end of the telescopic rod is connected with the inner bottom of the reaction kettle, the upper end of the telescopic rod is connected with a second partition plate, and the second partition plate divides the interior of the support column into an upper part and a lower part; the lower part of the adjusting layer and the lower part of the supporting column are filled with second liquid, the upper part of the adjusting layer and the upper part of the supporting column are filled with first liquid, and the second partition plate moves up and down in the supporting column under the action of the telescopic rod; when the second partition plate is positioned below the inner part of the support column, the first partition plate is positioned above the inner side surface of the reaction kettle and the outer side surface of the partition plate; when the second partition plate is positioned above the inner part of the support column, the first partition plate is positioned below the inner side surface of the reaction kettle and the outer side surface of the partition plate; a heating device is arranged below the reaction kettle, and a refrigerating device is arranged above the reaction kettle.
In the present apparatus, the stirring layer functions to mix the raw materials as a reaction chamber. The regulation layer is used for flowing liquid, when needs react under different temperature conditions, the telescopic link extension, the second baffle is located the inside top of support column, the second baffle is at the in-process of rebound, the second baffle extrudees first liquid, force first liquid to provide pressure to first baffle, liquid in the regulation layer is for keeping balance, first baffle atress moves down, at the in-process that removes, the second liquid is filled at the lower extreme of regulation layer and the inside of support column at last, heat the second liquid in the regulation layer lower extreme through heating device this moment, and then make the second liquid in support column and the regulation layer lower extreme all be in the required temperature of reaction, and then make reation kettle's inside be in required temperature.
When the temperature that does not need the heating or need be less than the normal atmospheric temperature, shorten the telescopic link, the telescopic link is the downstream, and the in-process extrusion that removes is located the inside second liquid of support column, the second liquid that is located in the regulating layer lower extreme receives pressure effect on first baffle, make first baffle atress rebound at last, first baffle is at the in-process that moves up, push back primary importance with first liquid, finally, first liquid is located the support column and the upper end on regulating layer, the refrigerating plant who is located the reation kettle upper end refrigerates, make the temperature of first liquid reduce, and then make inside being under the required temperature of reation kettle.
In the device, the first liquid is preferably water, and the second liquid is heat conduction oil. Because water and conduction oil are not mutually soluble, the effect of first liquid lies in the cooling, and the effect of second liquid lies in the heat transfer, and the conduction oil has better heat transfer effect, and water also can be applicable to most low temperature environment, simultaneously, when need not heat or cool down, the water level can be used to dispel the heat to reation kettle inner structure in the support column is inside. And secondly, water and heat conducting oil are easily obtained and stable in performance, so that the cost can be effectively saved and the device is safer when in use.
This device is when heating, and the second liquid is located the support column, and when needs cooling, first liquid is located the support column, consequently when using, and current reation kettle's difference still lies in, and this device begins temperature regulation from inside, and at the in-process of medicine midbody reaction, reaction efficiency is higher.
Concretely, the medial surface of reation kettle encloses with the lateral surface of division board and becomes the regulation layer, and first baffle will be divided into two parts about the regulation layer, and first baffle can reciprocate in the regulation layer, and first baffle moves down under the effect of first liquid, extrudees the second liquid, and first baffle upwards moves under the effect of second liquid, extrudes first liquid.
First baffle is the loop configuration, the inboard of the inner ring of first baffle contacts with the lateral surface of division board, the outside of the outer loop of first baffle contacts with reation kettle's medial surface, evenly distributed has four first sliders on the inboard of the inner ring of first baffle, evenly distributed has four second sliders on the outside of the outer loop of first baffle, all be provided with the gyro wheel on first slider and the second slider, be provided with the first spout that corresponds with first slider on the lateral surface of division board, be provided with the second spout that corresponds with the second slider on reation kettle's the medial surface, all be provided with little recess on the interior bottom of first spout and second spout. Set up four first sliders and four second sliders to make it contact with the lateral surface of division board respectively, and reation kettle's medial surface contacts, when receiving pressure, the division board can more steady move up, simultaneously, because the interior bottom surface of pulley and little recess contacts, consequently when using, can direct stable reciprocate after first baffle receives pressure, and the availability factor is higher.
On the basis once more, the upper end from the top down of support column has set gradually first spliced pole and second spliced pole, reation kettle's upper end is provided with first opening, the upper end of division board is provided with the second opening, first opening and first spliced pole threaded connection, second opening and second spliced pole threaded connection, connect through the connecting rod between first spliced pole and the second spliced pole, the connecting rod is arranged in the adjustment layer, and the inside intercommunication with the inside of adjustment layer and support column of connecting rod.
This device is when using, the support column passes through the first opening of reation kettle upper end and during the second opening entering stirring layer of division board upper end, the back is put into to the support column, the lower extreme and reation kettle's of support column bottom is connected, then the support column makes first spliced pole and first opening threaded connection on it at the in-process that rotates, second spliced pole and second opening threaded connection, first spliced pole is sealed with first opening after connecting, the second spliced pole is sealed with the second opening, connecting rod between first spliced pole and the second spliced pole is located the inside of adjustment layer upper end, and connecting rod and adjustment layer intercommunication, the inside of connecting rod and the inside intercommunication of support column, consequently when the second baffle reciprocates, can promote the inside flow of first liquid at adjustment layer upper end and support column.
Furthermore, a plurality of rotating columns are arranged on the side faces of the supporting columns, a plurality of stirring sheets are connected onto the rotating columns, and the rotating columns rotate on the supporting columns by taking the straight lines where the supporting columns are located as axes. A plurality of first connecting rods which are parallel to each other are sequentially arranged on one rotary column from top to bottom, one end of each first connecting rod is connected with the stirring sheet, the other end of each first connecting rod is vertically connected with one end of each second connecting rod, the other end of each second connecting rod is connected with one end of each third connecting rod, and the third connecting rods on one rotary column are all connected with driving rods; the supporting column is sleeved with a driving sleeve, a closed slideway is arranged on the side surface of the driving sleeve, and a third connecting rod at the uppermost end of one rotating column is connected with the slideway and slides along the slideway under the driving of the rotating column; the rotary column, the slide way and the driving rod enable the stirring sheet to rotate along the straight line where the first connecting rod is located as an axis. The support column of this device is used for the upper and lower both ends of intercommunication regulating layer, and the column spinner rotates on the support column, and the support dynamics of column spinner is less than the dynamics of support column, therefore the column spinner can carry out the further simplified structure of rotation ability, reduces sealed requirement, avoids liquid to flow into stirring in situ portion. The effect of column spinner in this device lies in driving the stirring piece that connects above that to use support column place straight line together as the axis rotation, and simultaneously, the third connecting rod that is located the top through a column spinner removes in the slide that drives the cover, the slide comprises highly inequality little slide, the third connecting rod of the top removes in the slide and then all follows the sharp at head rod place through the stirring piece that drives on the third connecting rod that the pole drove above that at the rotatory in-process of column spinner is rotatory for the axis, therefore this structure is only through the rotation of column spinner, just can drive the stirring piece and follow the rotatory in-process of support column place straight line as the axis, stirring piece self still follows the sharp at head rod place and is rotatory for the axis.
Furthermore, the rotary column comprises two side plates which are parallel to each other and a bottom plate which is vertical to the side plates, the bottom plate is parallel to the support columns, two ends of the bottom plate are respectively and vertically connected with one side plate, the rotary column forms a U shape through the two side plates and the bottom plate, the first connecting rod is vertically connected with the bottom plate, the rotary column rotates on the support columns, the rotary column is communicated with the stirring sheet and drives the stirring sheet to rotate together, in addition, two opposite side surfaces of the bottom plate are respectively provided with the illumination plates which are positioned on two sides of the side plates, therefore, when the reaction is needed under the illumination condition, in the device, the LED lamp irradiation direction of the LED lamp plate is in the tangential direction of the side surfaces of the support columns, meanwhile, the rotary column drives the LED lamp to rotate together in the rotating process, the illumination efficiency can be further improved, and the illumination can be contacted with more medicines, the reaction efficiency of the medicine under the illumination condition is improved.
And, be provided with the standing groove in the illumination board, the illumination board is transparent material, has placed the LED lamp plate in the standing groove, and the LED lamp plate includes LED lamp and two fixed plates, and threaded connection is passed through with the both ends of LED lamp respectively to two fixed plates, and the top of one of them fixed plate is provided with the lifting rope, and the side of this fixed plate is provided with the sealing layer. When the LED lamp needs to be replaced, the LED lamp panel is lifted out of the placing groove through the lifting rope, and then replacement is carried out.
Compared with the prior art, the invention has the following advantages and beneficial effects:
the device can be suitable for the preparation process of the drug intermediate at different temperatures, the heating or refrigerating positions of the device are the middle positions of the reaction kettle, and the heating device and the refrigerating device are respectively positioned below and above the reaction kettle. The structure of the reaction kettle can be effectively simplified.
The heating and refrigeration of the device are driven by the temperature transmission of liquid, and the heating or refrigeration temperature is uniform, so that the preparation efficiency of the drug intermediate under different temperature parameters can be further improved, and the drug preparation quality is improved.
Simultaneously, the stirring piece of this device can not only drive the stirring and use the support column to rotate as the axis under the structural action of this device, and its self still rotates to improve stirring efficiency. Secondly, be provided with the LED lamp on the side of the column spinner of this device, the illumination direction of LED lamp is tangent with the side of support column to the column spinner is at rotatory in-process, drives the LED lamp and rotates together, consequently to the medicine that needs react under the illumination condition, and the illumination that this device provided can fully contact with the medicine, increases illumination area, improves the preparation quality. The device has simple structure, no complex structure and convenient long-term use.
Drawings
The accompanying drawings, which are included to provide a further understanding of the embodiments of the invention and are incorporated in and constitute a part of this application, illustrate embodiment(s) of the invention and together with the description serve to explain the principles of the invention. In the drawings:
FIG. 1 is a schematic view of the present apparatus;
FIG. 2 is a schematic view of the device when the telescopic rod is extended;
FIG. 3 is a schematic view of a first separator plate;
FIG. 4 is a schematic structural view of a first connecting column and a second connecting column;
FIG. 5 is a schematic view of a spin column;
FIG. 6 is a top view of the spin column;
FIG. 7 is a schematic diagram of positions among the first connecting rod, the second connecting rod and the third connecting rod;
FIG. 8 is a side view of the driving sleeve;
FIG. 9 is a schematic view of an illumination panel;
fig. 10 is a schematic view of an LED lamp structure.
Reference numbers and corresponding part names in the drawings:
1-a reaction kettle, 2-a separation plate, 3-a support column, 4-a stirring layer, 5-a regulating layer, 6-a first partition plate, 61-an inner ring, 62-an outer ring, 63-a first slide block, 64-a second slide block, 7-a rotating column, 71-a driving rod, 72-a driving sleeve, 73-a slideway, 8-a third connecting rod, 9-a second connecting rod, 10-a first connecting rod, 11-a stirring sheet, 12-a telescopic rod, 13-a second partition plate, 14-a lighting plate, 15-a fixing plate, 16-a lifting rope, 17-an LED lamp, 18-a placing groove, 19-a first connecting column, 20-a second connecting column and 21-a heating device.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail below with reference to examples and accompanying drawings, and the exemplary embodiments and descriptions thereof are only used for explaining the present invention and are not meant to limit the present invention.
In the description of the present invention, it is to be understood that the terms "front", "rear", "left", "right", "upper", "lower", "vertical", "horizontal", "high", "low", "inner", "outer", etc. indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience of description and simplicity of description, and do not indicate or imply that the referenced devices or elements must have a particular orientation, be constructed and operated in a particular orientation, and therefore, are not to be construed as limiting the scope of the present invention.
[ example 1 ]
The device comprises a reaction kettle 1, as shown in figure 1, a partition plate 2 is arranged in the reaction kettle 1, the reaction kettle 1 is sequentially divided into a stirring layer 4 and an adjusting layer 5 from inside to outside by the partition plate 2, a support column 3 is arranged in the stirring layer 4, and the upper end and the lower end of the support column 3 are respectively communicated with the upper end and the lower end of the adjusting layer 5; a first partition plate 6 is arranged on the inner side surface of the reaction kettle 1 and the outer side surface of the partition plate 2, the first partition plate 6 divides the adjusting layer 5 into an upper part and a lower part, and the first partition plate 6 can move up and down on the inner side surface of the reaction kettle 1 and the outer side surface of the partition plate 2; the supporting column 3 is provided with a telescopic rod 12 which can be vertically stretched, the lower end of the telescopic rod 12 is connected with the inner bottom of the reaction kettle 1, the upper end of the telescopic rod 12 is connected with a second partition plate 13, and the second partition plate 13 divides the inside of the supporting column 3 into an upper part and a lower part; the lower parts of the adjusting layers 5 and the supporting columns 3 are filled with second liquid, the upper parts of the adjusting layers 5 and the supporting columns 3 are filled with first liquid, and the second partition plates 13 move up and down in the supporting columns 3 under the action of the telescopic rods 12; when the second partition plate 13 is positioned below the inside of the support column 3, the first partition plate 6 is positioned above the inner side surface of the reaction kettle 1 and the outer side surface of the partition plate 2; when the second partition plate 13 is positioned above the inside of the support column 3, the first partition plate 6 is positioned below the inner side surface of the reaction kettle 1 and the outer side surface of the partition plate 2; a heating device 21 is arranged below the reaction kettle 1, and a refrigerating device is arranged above the reaction kettle 1.
In this embodiment, a top view of the first partition board is shown in fig. 2, the first partition board 6 is an annular structure, an inner side of an inner ring 61 of the first partition board 6 contacts with an outer side surface of the partition board 2, an outer side of an outer ring 62 of the first partition board 6 contacts with an inner side surface of the reaction kettle 1, four first sliding blocks 63 are uniformly distributed on the inner side of the inner ring 61 of the first partition board 6, four second sliding blocks 64 are uniformly distributed on the outer side of the outer ring 62 of the first partition board 6, rollers are arranged on the first sliding blocks 63 and the second sliding blocks 64, a first sliding groove corresponding to the first sliding blocks 63 is arranged on the outer side surface of the partition board 2, a second sliding groove corresponding to the second sliding blocks 64 is arranged on the inner side surface of the reaction kettle 1, and small grooves are arranged on inner bottom portions of the first sliding grooves and. The gyro wheel contacts with the interior bottom of little recess, first baffle is at the in-process that reciprocates, the gyro wheel reciprocates in little recess, first baffle is connected on reation kettle 1's medial surface and the lateral surface of division board, divide into two upper and lower regions with the adjustment layer, second baffle 13 is divided into two upper and lower regions with the inside of support column, the upper portion and the inside upper portion intercommunication of support column of adjustment layer, the lower part and the inside lower part intercommunication of support column of adjustment layer, it has first liquid to fill in the upper portion of adjustment layer and the inside upper portion of support column, it has second liquid to fill in the lower part of adjustment layer and the inside lower part of support column, the second baffle passes through the telescopic link and reciprocates inside the support column, and reciprocate at the in-process that removes through the first baffle of the effect drive of first liquid and second liquid.
In this embodiment, when the reaction kettle needs to react at low temperature or normal temperature, the telescopic rod is shortened to enable the second partition plate to be located at the lower end inside the support column, that is, as shown in fig. 1, at this time, the first liquid is located in the upper portion of the adjusting layer and the upper portion of the support column, if the reaction is needed at normal temperature, the refrigeration device does not work, the first liquid located in the upper portion of the support column dissipates heat inside the reaction kettle, when the reaction is needed to be performed at a temperature lower than the room temperature, the refrigeration device is adjusted to a required temperature, then the refrigeration device refrigerates the first liquid in the upper portion of the adjusting layer, and transmits the temperature to the first liquid in the upper portion inside the support column. The first liquid in the upper part inside the supporting column cools the inside of the reaction kettle to reach the required temperature.
When reation kettle need react under the heating condition, the telescopic link extension, make the second baffle be located the inside upper end of support column, as shown in fig. 3 promptly, after the telescopic link extension, the telescopic link drives the second baffle at the inside rebound of support column, the first liquid in the inside upper portion of support column is driven at the in-process of rebound to the second baffle removes, and extrude first baffle and move down, last second baffle is located the inside top of support column, the inside at the support column is filled to the second liquid, heating device heats the second liquid of adjustment layer lower extreme, the second liquid of adjustment layer lower extreme is heated and is given the second liquid in the inside lower part of support column in with the heat transfer, the second liquid is heated and heats reation kettle inside, make it reach required temperature.
[ example 2 ]
In example 1, the first liquid is water and the second liquid is a heat transfer oil. The upper end from the top down of support column 3 has set gradually first spliced pole 19 and second spliced pole 20, reation kettle 1's upper end is provided with first opening, the upper end of division board 2 is provided with the second opening, first opening and 19 threaded connection of first spliced pole, second opening and 20 threaded connection of second spliced pole, after first spliced pole 19 and second spliced pole 20 are connected with first opening and second opening respectively, its structure is shown in figure 4, be provided with a plurality of through-holes on the connecting rod between first spliced pole 19 and the second spliced pole 20, the connecting rod communicates with the inside of regulation layer and the inside of support column.
As shown in fig. 5, in the present embodiment, four rotating columns 7 are disposed on the side surface of the supporting column 3, four stirring blades 11 are connected to one rotating column 7, and the rotating column 7 rotates on the supporting column 3 with the straight line of the supporting column 3 as the axis. Moreover, four mutually parallel first connecting rods 10 are sequentially arranged on one rotary column 7 from top to bottom, one end of each first connecting rod 10 is connected with the stirring sheet 11, the other end of each first connecting rod 10 is vertically connected with one end of the corresponding second connecting rod 9, the other end of each second connecting rod 9 is connected with one end of each third connecting rod 8, and the third connecting rods 8 on one rotary column 7 are all connected with driving rods 71; the support column 3 is sleeved with a driving sleeve 72, a closed slide way 73 is arranged on the side surface of the driving sleeve 72, and the third connecting rod 8 at the uppermost end of one rotary column 7 is connected with the slide way 73 and slides along the slide way 73 under the driving of the rotary column 7; the rotating column 7, the slide 73 and the driving rod 71 rotate the stirring blade 11 along the straight line of the first connecting rod 10 as an axis. The top views of the four rotating columns are shown in fig. 6, fig. 7 is a connection relationship among the first connecting rod, the second connecting rod and the third connecting rod, the side view of the driving sleeve 72 is shown in fig. 8, the rotating columns drive the uppermost third connecting rod to slide in the slide ways in the rotating process, and one slide way is composed of small slide ways with different heights at two ends and inclined slide ways connecting the two small slide ways with different heights, so that the first third connecting rod on the rotating column and the stirring pieces on the first third connecting rod can be driven to rotate by taking the first connecting rod as an axis while the third connecting rod slides. Meanwhile, the first third connecting rod drives the driving rod to reciprocate together, the driving rod drives the rest third connecting rods to move together, and all stirring blades on one rotating column can rotate along the first connecting rod as an axis.
[ example 3 ]
On embodiment 2's basis, the column spinner 7 includes two curb plates that are parallel to each other and with curb plate vertically bottom plate, the bottom plate is parallel to each other with support column 3, the both ends of bottom plate are connected with a curb plate is perpendicular respectively, head rod 10 is connected with the bottom plate is perpendicular, two relative sides of bottom plate all are provided with illumination board 14, illumination board 14 is located the both sides of curb plate, be provided with standing groove 18 in the illumination board 14, the LED lamp plate has been placed in the standing groove 18, the LED lamp plate includes LED lamp 17 and two fixed plates 15, two fixed plates 15 pass through threaded connection with the both ends of LED lamp 17 respectively, the top of one of them fixed plate 15 is provided with lifting rope 16, the side of this fixed plate 15 is provided with the sealing layer.
As shown in fig. 9, the rotary column 7 includes two parallel side plates and a bottom plate perpendicular to the side plates, the bottom plate is parallel to the support column 3, two ends of the bottom plate are respectively connected with one side plate perpendicularly, the first connecting rod 10 is connected with the bottom plate perpendicularly, two opposite sides of the bottom plate are provided with the lighting plate 14, the lighting plate 14 is located at two sides of the side plate, a placing groove 18 is arranged in the lighting plate 14, an LED lamp plate is placed in the placing groove 18, the structure of the LED lamp plate is shown in fig. 10, the LED lamp plate includes an LED lamp 17 and two fixing plates 15, the two fixing plates 15 are respectively connected with two ends of the LED lamp 17 through threads, a lifting rope 16 is arranged above one of the fixing plates 15, and a sealing layer is arranged at one side of.
When using, the LED lamp is located standing groove 18, and standing groove 18 is transparent material, and the column spinner drives standing groove 18 and the LED lamp in it to rotate together when rotatory, and the LED lamp shines the medicine in the stirring layer at rotatory in-process to the LED lamp can not contact with the medicine, also can increase illumination area effectively simultaneously.
[ example 4 ]
On embodiment 1's basis, the column spinner provides power through the motor and rotates, the extending structure of telescopic link is also current structure, and the telescopic link is arranged in the lower part of adjusting device and the lower part of support column, the telescopic link contacts with the conduction oil, enable it to keep better scalability, the telescopic link of this embodiment is current extending structure, simultaneously heating device in this embodiment can be for heating current heating device such as resistance wire or microwave heating device, heat the conduction oil in the lower part of regulation layer through heating device, enable its quick required temperature that reaches, and the stable performance, also can make the heat conduction in the lower part of support column also reach required temperature fast simultaneously, temperature distribution is even.
When need not heating or need use in lower temperature environment, the telescopic link shortens, and the water level is in the inside upper portion of support column, and refrigerating plant refrigerates the water of adjustment layer top, and the refrigerating plant of this embodiment is current structure, and the water of adjustment layer top gives the inside water of support column with the temperature transfer, and then cools down the temperature in to reation kettle.
When the inside of this device need be changed, through rotatory first spliced pole 19, first spliced pole passes through the connecting rod and drives second spliced pole and support column and rotate together, and the lower extreme of support column and the lower extreme of regulation layer also pass through threaded connection, and the lower extreme of telescopic link passes the lower extreme of regulation layer and is connected with the outside controller that is located this device, and controller control telescopic link is flexible.
First spliced pole and second spliced pole break away from with first opening and second opening at rotatory in-process, and then accessible first opening and second opening take out the support column from reation kettle, and then can change the support column and LED lamp isotructure on it as required.
The term "connected" used herein may be either directly connected or indirectly connected via other components without being particularly described.
The above-mentioned embodiments are intended to illustrate the objects, technical solutions and advantages of the present invention in further detail, and it should be understood that the above-mentioned embodiments are merely exemplary embodiments of the present invention, and are not intended to limit the scope of the present invention, and any modifications, equivalent substitutions, improvements and the like made within the spirit and principle of the present invention should be included in the scope of the present invention.
Claims (8)
1. A drug intermediate reaction kettle for drug synthesis is characterized by comprising a reaction kettle (1), wherein a partition plate (2) is arranged in the reaction kettle (1), the reaction kettle (1) is sequentially divided into a stirring layer (4) and an adjusting layer (5) from inside to outside by the partition plate (2), a support column (3) is arranged in the stirring layer (4), and the upper end and the lower end of the support column (3) are respectively communicated with the upper end and the lower end of the adjusting layer (5); a first partition plate (6) is arranged on the inner side surface of the reaction kettle (1) and the outer side surface of the partition plate (2), the first partition plate (6) divides the adjusting layer (5) into an upper part and a lower part, and the first partition plate (6) can move up and down on the inner side surface of the reaction kettle (1) and the outer side surface of the partition plate (2); a telescopic rod (12) which can be vertically stretched is arranged in the supporting column (3), the lower end of the telescopic rod (12) is connected with the inner bottom of the reaction kettle (1), the upper end of the telescopic rod (12) is connected with a second partition plate (13), and the second partition plate (13) divides the inside of the supporting column (3) into an upper part and a lower part; the lower part of the adjusting layer (5) and the lower part of the supporting column (3) are filled with second liquid, the upper part of the adjusting layer (5) and the upper part of the supporting column (3) are filled with first liquid, and the second partition plate (13) moves up and down in the supporting column (3) under the action of the telescopic rod (12); when the second partition plate (13) is positioned below the inner part of the support column (3), the first partition plate (6) is positioned above the inner side surface of the reaction kettle (1) and the outer side surface of the partition plate (2); when the second partition plate (13) is positioned above the inside of the support column (3), the first partition plate (6) is positioned below the inner side surface of the reaction kettle (1) and the outer side surface of the partition plate (2); a heating device (21) is arranged below the reaction kettle (1), and a refrigerating device is arranged above the reaction kettle (1).
2. The drug intermediate reaction kettle for drug synthesis as claimed in claim 1, wherein the first liquid is water, and the second liquid is heat transfer oil.
3. The intermediate reaction kettle for drug synthesis according to claim 1, wherein the first partition plate (6) has an annular structure, the inner side of the inner ring (61) of the first partition plate (6) is in contact with the outer side of the partition plate (2), the outer side of the outer ring (62) of the first partition plate (6) is in contact with the inner side of the reaction kettle (1), four first sliding blocks (63) are uniformly distributed on the inner side of the inner ring (61) of the first partition plate (6), four second sliding blocks (64) are uniformly distributed on the outer side of the outer ring (62) of the first partition plate (6), the first sliding blocks (63) and the second sliding blocks (64) are both provided with rollers, the outer side of the partition plate (2) is provided with a first sliding groove corresponding to the first sliding blocks (63), the inner side of the reaction kettle (1) is provided with a second sliding groove corresponding to the second sliding blocks (64), and the inner bottoms of the first sliding grooves and the second sliding grooves are both provided with small grooves.
4. The drug intermediate reaction kettle for drug synthesis as claimed in claim 1, wherein a first connecting column (19) and a second connecting column (20) are sequentially arranged at the upper end of the supporting column (3) from top to bottom, a first opening is arranged at the upper end of the reaction kettle (1), a second opening is arranged at the upper end of the partition plate (2), the first opening is in threaded connection with the first connecting column (19), the second opening is in threaded connection with the second connecting column (20), the first connecting column (19) and the second connecting column (20) are connected through a connecting rod, the connecting rod is located in the adjusting layer (5), and the inside of the connecting rod is communicated with the adjusting layer (5) and the inside of the supporting column (3).
5. The drug intermediate reaction kettle for drug synthesis as claimed in claim 1, wherein a plurality of rotary columns (7) are arranged on the side surface of the support column (3), a plurality of stirring sheets (11) are connected to the rotary columns (7), and the rotary columns (7) rotate on the support column (3) with the straight line where the support column (3) is located as an axis.
6. The drug intermediate reaction kettle for drug synthesis as claimed in claim 5, wherein a plurality of first connecting rods (10) parallel to each other are sequentially arranged on one rotary column (7) from top to bottom, one end of each first connecting rod (10) is connected with the stirring plate (11), the other end of each first connecting rod (10) is vertically connected with one end of each second connecting rod (9), the other end of each second connecting rod (9) is connected with one end of each third connecting rod (8), and the third connecting rods (8) on one rotary column (7) are connected with driving rods (71); a driving sleeve (72) is sleeved on the supporting column (3), a closed slide way (73) is arranged on the side surface of the driving sleeve (72), and a third connecting rod (8) at the uppermost end of one rotating column (7) is connected with the slide way (73) and slides along the slide way (73) under the driving of the rotating column (7); the rotating column (7), the slide way (73) and the driving rod (71) enable the stirring sheet (11) to rotate along the straight line where the first connecting rod (10) is located as an axis.
7. The drug intermediate reaction kettle for drug synthesis as claimed in claim 5, wherein the rotary column (7) comprises two parallel side plates and a bottom plate perpendicular to the side plates, the bottom plate and the support column (3) are parallel to each other, two ends of the bottom plate are perpendicular to one side plate respectively, the first connecting rod (10) is perpendicular to the bottom plate, two opposite side surfaces of the bottom plate are provided with the illumination plates (14), the illumination plates (14) are located at two sides of the side plates, a placement groove (18) is arranged in the illumination plates (14), an LED lamp panel is placed in the placement groove (18), the LED lamp panel comprises an LED lamp (17) and two fixing plates (15), the two fixing plates (15) are respectively connected with two ends of the LED lamp (17) through threads, a lifting rope (16) is arranged above one fixing plate (15), and a sealing layer is arranged on the side surface of the fixing plate (15).
8. The drug intermediate reaction kettle for drug synthesis as claimed in claim 1, wherein the heating device (21) is a microwave heating device.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202011404583.6A CN112516947B (en) | 2020-12-04 | 2020-12-04 | Medicine midbody reation kettle for drug synthesis |
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| CN202011404583.6A CN112516947B (en) | 2020-12-04 | 2020-12-04 | Medicine midbody reation kettle for drug synthesis |
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| JPH06127901A (en) * | 1992-10-15 | 1994-05-10 | Nippon Steel Corp | Method and device for rapidly occluding and discharging hydrogen |
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| CN112516947B (en) | 2022-11-08 |
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Effective date of registration: 20221018 Address after: 271000 West of Dongzhuang Road, south of Guchenghe Street, Ningyang Economic Development Zone, Tai'an City, Shandong Province Applicant after: Shandong Zhongjing Biotechnology Co.,Ltd. Address before: 611630 No.17, group 14, Futian village, Xilai Town, Pujiang County, Chengdu City, Sichuan Province Applicant before: Wu Fan |
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