CN112490109B - Time domain enhanced ion migration tube - Google Patents
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- CN112490109B CN112490109B CN202011329365.0A CN202011329365A CN112490109B CN 112490109 B CN112490109 B CN 112490109B CN 202011329365 A CN202011329365 A CN 202011329365A CN 112490109 B CN112490109 B CN 112490109B
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- 230000005012 migration Effects 0.000 title claims abstract description 135
- 238000013508 migration Methods 0.000 title claims abstract description 135
- 230000005684 electric field Effects 0.000 claims abstract description 89
- 238000012546 transfer Methods 0.000 claims abstract description 33
- 230000035945 sensitivity Effects 0.000 claims abstract description 11
- 150000002500 ions Chemical class 0.000 claims description 210
- 230000009471 action Effects 0.000 claims description 13
- 230000003287 optical effect Effects 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 4
- 238000004458 analytical method Methods 0.000 abstract description 4
- 230000006835 compression Effects 0.000 abstract description 4
- 238000007906 compression Methods 0.000 abstract description 4
- 238000013461 design Methods 0.000 abstract description 2
- 238000002347 injection Methods 0.000 abstract description 2
- 239000007924 injection Substances 0.000 abstract description 2
- 238000005468 ion implantation Methods 0.000 abstract description 2
- DQWPFSLDHJDLRL-UHFFFAOYSA-N triethyl phosphate Chemical group CCOP(=O)(OCC)OCC DQWPFSLDHJDLRL-UHFFFAOYSA-N 0.000 description 14
- 239000000178 monomer Substances 0.000 description 6
- 230000004304 visual acuity Effects 0.000 description 6
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 4
- 238000001871 ion mobility spectroscopy Methods 0.000 description 4
- -1 triethylphosphate ion Chemical class 0.000 description 4
- 238000001514 detection method Methods 0.000 description 3
- 230000003068 static effect Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 230000007704 transition Effects 0.000 description 2
- 238000004061 bleaching Methods 0.000 description 1
- 239000008358 core component Substances 0.000 description 1
- 239000002019 doping agent Substances 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000001269 time-of-flight mass spectrometry Methods 0.000 description 1
Classifications
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/0027—Methods for using particle spectrometers
- H01J49/0031—Step by step routines describing the use of the apparatus
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/06—Electron- or ion-optical arrangements
- H01J49/062—Ion guides
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- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Abstract
The invention discloses a time domain electric field enhanced ion migration tube. The ion transfer tube realizes the time domain multistage enhancement of the electric field intensity in the transfer region by controlling the optocoupler switch. In the time interval of ion gate opening and ion group injection, all the optocoupler switches are in an off state, and an initial migration electric field is maintained in the ion migration tube; after ion implantation is completed by the ion gate, the opto-coupler switch is sequentially switched from an off state to an on state according to a specific time sequence, a time domain enhanced migration electric field is formed in the ion migration region, the time domain width and the current density of the ion mass in the ion migration region are subjected to multistage compression and enhancement, and finally an ion migration spectrogram with ultrahigh resolution and ultrahigh sensitivity is formed. According to the ion migration tube design, a high-voltage power supply with a low maximum output voltage value can be utilized to obtain analysis performance with ultrahigh resolution capability and ultrahigh sensitivity, so that the instrument cost is reduced, and the use safety of the instrument is improved.
Description
Technical Field
The invention relates to an ion migration tube of a core component of an ion migration spectrometer, in particular to an ion migration tube which electrically shorts adjacent conductive electrodes in an ionization region according to a specific time sequence to realize time domain enhancement of electric field intensity in the migration region.
Background
Migration time ion mobility spectrometry (Ion Mobility Spectrometry, IMS) is a pulsed ion mass separation and detection technique that resembles time-of-flight mass spectrometry. The time domain width of the ion clusters and the ion current density directly determine the resolving power and detection sensitivity of the ion mobility spectrometry.
The disclosed research shows that the ion migration electric field with the intensity enhanced along with time domain jump can effectively reduce the time domain width of the ion mass and improve the ion current density. Du Yongzhai et al (Anal.Chem.2012, 92,12967;US9293313B2) illustrate for the first time that ion gate opening and closing induced time domain hopping enhanced electric fields can compress the time domain width of an ion mass and thus disclose a spatially focused ion gate apparatus; chen Chuang et al (sensor. Act. B-chem.,2019,295,179) further found in research that the enhanced electric field of time domain jump induced by opening and closing the ion gate can also increase the ion current density of the ion stream or ion clusters, thereby achieving an increase in the sensitivity of target detection.
In order to improve the analysis performance of ion mobility spectrometry by using a high-intensity ion mobility electric field, bohnhorst et al (Anal. Chem.2020,92,12967) divide a mobility region of an ion mobility tube into N sections, apply a voltage only to a part of the continuous sections thereof, and move the section to which the voltage is applied in a direction from an ion gate to an ion receiving electrode, thereby obtaining a high-intensity mobility electric field in the mobility region by using a high-voltage power supply having a low output value, and improving the resolving power. However, in this technique, an electric field is applied only to a part of the migration region, so that the mobility range of the analyzable ions is limited, and all the ions in the migration region cannot be analyzed and detected.
The invention discloses a time domain electric field enhanced ion migration tube. In the ion transfer tube, adjacent conductive electrodes in the ionization region are connected with the optocoupler switch, and the adjacent conductive electrodes in the ionization region can be electrically short-circuited according to a specific time sequence by controlling the optocoupler switch, so that the time domain multistage enhancement of the electric field intensity in the transfer region is realized. In the time interval of ion gate opening and ion group injection, all the optocoupler switches are in an off state, and an initial migration electric field is maintained in the ion migration tube; after ion implantation is completed by the ion gate, the opto-coupler switch is sequentially switched from an off state to an on state according to a specific time sequence, a time domain enhanced migration electric field is formed in the ion migration region, the time domain width and the current density of the ion mass in the ion migration region are subjected to multistage compression and enhancement, and finally an ion migration spectrogram with ultrahigh resolution and ultrahigh sensitivity is formed. According to the ion migration tube design, a high-voltage power supply with a low maximum output voltage value can be utilized to obtain analysis performance with ultrahigh resolution capability and ultrahigh sensitivity, so that the instrument cost is reduced, and the use safety of the instrument is improved.
Disclosure of Invention
The invention aims to provide an ion migration tube with enhanced time domain electric field intensity in a migration zone. On one hand, the time domain width and the current density of the ion clusters in the ion migration zone are subjected to multistage compression and enhancement to form an ion migration spectrogram with ultrahigh resolution and ultrahigh sensitivity; on the other hand, the requirement on the maximum output value of the high-voltage power supply is reduced, the instrument cost is reduced, and the use safety of the instrument is improved.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows:
a time domain electric field enhanced ion mobility tube. The ion transfer tube is a hollow columnar cavity formed by sequentially alternately and coaxially overlapping an annular conductive pole piece and an annular insulating pole piece; an ion source and an ion receiving electrode are respectively arranged at two ends of the cavity; an ion gate is arranged between the ion source and the ion receiving electrode in the cavity, the cavity is divided into two areas, an ionization area is formed between the ion source and the ion gate, and a migration area is formed between the ion gate and the ion receiving electrode;
the ion source, the annular conductive pole piece, the ion gate and the ion receiving pole are connected in series through a voltage dividing resistor in sequence, the ion source is connected with a high-voltage output terminal of a direct-current high-voltage power supply, and the ion receiving pole is grounded to form electric connection, so that an initial migration electric field is formed in the ion migration tube;
the ionization region consists of M+1 annular conductive pole pieces and M annular insulating pole pieces; m is a positive integer greater than or equal to 3; adjacent two annular conductive pole pieces in the ionization region are connected through the optocoupler switches, namely M+1 annular conductive pole pieces are connected in series through the M optocoupler switches in sequence;
along the direction from the ion source to the ion gate, a first annular conductive pole piece and a second annular conductive pole piece of the ionization region are connected with a first optocoupler switch, the second annular conductive pole piece and a third annular conductive pole piece are connected with a second optocoupler switch, the M-1 th annular conductive pole piece and the M-1 th annular conductive pole piece are connected with an M-1 th optocoupler switch, and the M-1 th annular conductive pole piece and the M+1 th annular conductive pole piece are connected with an M optocoupler switch;
at the zeroth preset time interval t 0 In, first opto-coupler switch, second opto-coupler switch, & gt, the third opto-coupler switch and the fourth opto-coupler switch are all in an off state, and transition is carried outMaintaining an initial migration electric field in the migration zone, opening an ion gate, and enabling ions in the ionization zone to enter the migration zone through the ion gate to form an ion group;
at a first preset time interval t 1 The first optocoupler switch is in an on state, the second optocoupler switch, the third optocoupler switch and the M-1 optocoupler switch are in an off state, the ion gate is closed, a first migration electric field with enhanced strength is formed in the migration area, ions in the ionization area are blocked at the ion gate, ion groups in the migration area are compressed for the first time under the action of the first migration electric field, and the ion current density is enhanced for the first time; at a second preset time interval t 2 The first optocoupler switch and the second optocoupler switch are in an on state, the third optocoupler switch, the M-1 optocoupler switch and the M-1 optocoupler switch are in an off state, the ion gate is closed, a second migration electric field with enhanced strength is formed in the migration area, the time domain width of the ion clusters in the migration area is compressed for the second time under the action of the second migration electric field, and the ion current density is enhanced for the second time; … …; at the M-1 th preset time interval t m-1 The first optocoupler switch, the second optocoupler switch, the M-2 optocoupler switch and the M-1 optocoupler switch are all in an on state, the M-2 optocoupler switch is in an off state, the ion gate is closed, an M-1 migration electric field with enhanced strength is formed in the migration area, the ion group in the migration area is compressed for the M-1 time under the action of the M-1 migration electric field, and the ion current density is enhanced for the M-1 time; at the M-th preset time interval t m The first optocoupler switch, the second optocoupler switch, the M-1 optocoupler switch and the M optocoupler switch are all in an on state, the ion gate is closed, an M-th migration electric field with enhanced strength is formed in the migration area, the ion clusters in the migration area are compressed for the M-th time under the action of the M-th migration electric field, the ion current density is enhanced for the M-th time and finally received by the ion receiving electrode, and an ion migration spectrogram with ultra-high resolution capability and ultra-high sensitivity is formed;
the intensity of the M-th migration electric field is higher than that of the M-1 th migration electric field, the intensity of the M-1 th migration electric field is higher than that of the M-2 nd migration electric field, … …, the intensity of the second migration electric field is higher than that of the first migration electric field, and the intensity of the first migration electric field is higher than that of the initial migration electric field;
the initial migration electric field, the first migration electric field, the second migration electric field, … …, the M-1 migration electric field and the M migration electric field satisfy E/N between more than 0 and less than or equal to 4Td, wherein E represents electric field strength and N represents gas molecular number density;
a drift gas inlet is formed in the side wall of the migration zone, which is close to one end of the ion receiving electrode, and a sample gas inlet and a tail gas outlet are formed in the side wall of the ionization zone, which is close to one end of the ion source;
the ion gate is any one of a Bradbury-Neilson type ion gate and a Tyndall-Powell type ion gate;
the ion source is any ion source capable of ionizing sample gas molecules under atmospheric pressure conditions;
zeroth preset time interval t 0 First preset time interval t 1 A second preset time interval t 2 … …, mth-1 preset time interval t m-1 With the M preset time interval t m And constitutes a complete duty cycle of the ion gate according to which the ion gate is cycled.
The invention has the advantages that:
the invention discloses a time domain electric field enhanced ion migration tube, which is an ion migration tube for electrically shorting adjacent conductive electrodes in an ionization region according to a specific time sequence to realize time domain enhancement of electric field intensity in the migration region. On one hand, the ion migration tube technology can perform multistage compression and enhancement on the time domain width and the current density of the ion groups in the ion migration area to form an ion migration spectrogram with ultrahigh resolution and ultrahigh sensitivity; on the other hand, by using a high-voltage power supply with a low maximum output voltage value, high migration electric field intensity can be obtained in a migration zone, so that better analysis performance is obtained, the cost of the instrument is reduced, and the use safety of the instrument is improved.
The invention is described in further detail below with reference to the accompanying drawings:
drawings
Fig. 1 is a schematic cross-sectional view of a time domain electric field enhanced ion mobility tube according to the present invention. Wherein: 1. an ultraviolet light ion source; 2. an ionization region; 3. Tyndall-Powell type ion gate; 4. a migration zone; 5. an ion receiving electrode; 6. an annular conductive pole piece; 7. an annular insulating pole piece; 8. a voltage dividing resistor chain; 9. an optocoupler switch; 10. a bleaching gas inlet; 11. a sample gas inlet; 12. and a tail gas outlet. The ionization region 2 contains 6 annular conductive pole pieces, and the adjacent annular conductive pole pieces are respectively connected with 5 optocoupler switches 9.
Fig. 2 illustrates a time domain waveform of the electric field intensity in the transition zone of the time domain electric field enhanced ion mobility tube disclosed in fig. 1. Wherein t is 0 =0.05ms is the zeroth preset time interval, t 1 =0.6ms is the first preset time interval, t 2 =0.6ms is the second preset time interval, t 3 =0.6ms is the third preset time interval, t 4 =0.6ms is the fourth preset time interval, t 5 =0.6ms is the fifth preset time interval.
FIG. 3 (a) is a graph of 50ppb triethylphosphate signal obtained at an ion gate open time of 0.05ms for a time-domain enhanced ion transfer tube disclosed herein, corresponding to example 1; (b) The ion transfer tube disclosed by the invention works in a time domain static electric field mode (namely 5 optocoupler switches 9 are always in an off state, a transfer electric field of 600V/cm is kept unchanged in the ion transfer tube), and a spectrogram signal of 50ppb of triethyl phosphate obtained when the opening time of an ion gate is 0.05ms corresponds to that of comparative example 1; (c) The ion transfer tube disclosed by the invention works in a time domain static electric field mode (namely 5 optocoupler switches 9 are always in an off state, the transfer electric field of 800V/cm is kept unchanged in the ion transfer tube), and a spectrogram signal of 50ppb of triethyl phosphate is obtained when the opening time of an ion gate is 0.05ms, and corresponds to comparative example 2.
Detailed Description
Example 1
The invention discloses a time domain electric field enhanced ion migration tube, which is shown in figure 1. The ion source 1 of the ion transfer tube is a VUV photoionization source of 10.6eV, and acetone is used as a dopant in the ion source; the ion gate 3 is a Tyndall-Powell type ion gate formed by double parallel grids; the ion receiving electrode 5 is a Faraday disc with the diameter of 6mm and is fixed on a metal shielding cylinder with the outer diameter of 30 mm; the ionization region 2 and the migration region 4 are formed by alternately overlapping annular conductive pole pieces 6 with the thickness of 1mm, the inner diameter of 20mm and the outer diameter of 30mm and annular insulating pole pieces 7 with the thickness of 4mm, the inner diameter of 20mm and the outer diameter of 30mm, wherein the ionization region 2 contains 6 annular conductive pole pieces 6, and the migration region 4 contains 6 annular conductive pole pieces; along the direction from the ion source 1 to the ion gate 3, a first annular conductive pole piece and a second annular conductive pole piece of the ionization region 2 are connected with a first optocoupler switch 9, the second annular conductive pole piece and a third annular conductive pole piece are connected with the second optocoupler switch, the third annular conductive pole piece and a fourth annular conductive pole piece are connected with the third optocoupler switch, the fourth annular conductive pole piece and a fifth annular conductive pole piece are connected with the fourth optocoupler switch, and the fifth annular conductive pole piece and a sixth annular conductive pole piece are connected with the fifth optocoupler switch; in the initial state, the first optical coupler switch, the second optical coupler switch, the third optical coupler switch, the fourth optical coupler switch and the fifth optical coupler switch are all in an off state; the ion source 1, the annular conductive pole piece 6, the ion gate 3 and the shielding barrel of the ion receiving pole 5 are electrically connected with a high-voltage output terminal of a high-voltage power supply and the ground through a voltage dividing resistor chain 8 formed by connecting 11 2MΩ resistors end to end; the output value of the high-voltage power supply is 3300V, and an initial migration electric field of 600V/cm is formed in the ion migration tube;
the temperature of the ion transfer tube is set to be 100 ℃, the air is purified at 500mL/min, the air enters the ion transfer tube through an air inlet 10, the sample gas is 50ppb triethyl phosphate prepared by using the purified air, the flow rate is 100mL/min, the sample gas enters an ionization region 2 of the ion transfer tube through an air inlet 11, and the air and the sample gas finally flow out of the ion transfer tube through a tail gas outlet 12;
at the zeroth preset time interval t 0 In 0.05ms, the first, second, third, fourth and fifth opto-coupler switches are kept in an initial off state, an initial transfer electric field of 600V/cm is maintained in the transfer zone 4, the ion gate 3 is opened, and ions in the ionization zone 2 enter the transfer zone 4 through the ion gate 3 to form ion clusters;
at a first preset time intervalt 1 In 0.6ms, the first optocoupler switch is in an on state, the second optocoupler switch, the third optocoupler switch, the fourth optocoupler switch and the fifth optocoupler switch are kept in an off state, the ion gate 3 is closed, a first migration electric field with the intensity of 660V/cm is formed in the migration region 4, ions in the ionization region 2 are blocked at the ion gate 3, the ion clusters in the migration region 4 are compressed for the first time under the action of the first migration electric field, and the ion current density is enhanced for the first time;
at a second preset time interval t 2 In 0.6ms, the first optocoupler switch and the second optocoupler switch are in an on state, the third optocoupler switch, the fourth optocoupler switch and the fifth optocoupler switch are kept in an off state, the ion gate 3 is closed, a second migration electric field with the intensity of 733V/cm is formed in the migration region 4, the ion clusters in the migration region 4 are compressed for the second time in time domain width under the action of the second migration electric field, and the ion current density is enhanced for the second time;
at a third preset time interval t 3 In 0.6ms, the first, second and third opto-coupler switches are turned on, the fourth and fifth opto-coupler switches are kept turned off, the ion gate 3 is turned off, a third migration electric field with the intensity of 825V/cm is formed in the migration region 4, the ion clusters in the migration region (4) are compressed for the third time under the action of the third migration electric field, and the ion current density is enhanced for the third time;
at a fourth preset time interval t 4 In 0.6ms, the first optocoupler switch, the second optocoupler switch, the third optocoupler switch and the fourth optocoupler switch are in an on state, the fifth optocoupler switch is kept in an off state, the ion gate 3 is closed, a fourth migration electric field with the intensity of 943V/cm is formed in the migration region 4, the ion clusters in the migration region 4 are compressed for the fourth time in time domain width under the action of the fourth migration electric field, and the ion current density is enhanced for the fourth time;
at a fifth preset time interval t 5 In 0.6ms, the first, second, third, fourth and fifth opto-coupler switches are all on, the ion gate 3 is closed, and a fifth migration electric field with an intensity of 1100V/cm is formed in the migration region 4The ion clusters in the migration zone 4 are compressed for the fifth time under the action of a fifth migration electric field, the ion current density is enhanced for the fifth time and finally received by the ion receiving electrode 5, and a triethylphosphate ion migration spectrogram with ultrahigh resolution and ultrahigh sensitivity is formed, as shown in fig. 3a, wherein the acetone ion peak is 550pA, and the resolution is 60; the peak of the triethyl phosphate monomer ion is 145pA, and the resolution is 66; the triethylphosphate monomer ion peak was 80pA with a resolution of 62.
Comparative example 1
In order to compare the performance of the time domain electric field enhanced ion transfer tube disclosed by the invention, the response spectrum of 50ppb triethylphosphate when the ion gate opening time is 0.05ms is shown in fig. 3b, wherein the acetone ion peak is 263pA and the resolution capability is 36, wherein the ion transfer tube is also collected in the experimental process to work under a time domain static electric field (namely, 5 optocoupler switches 9 are always in an off state, and the transfer electric field of 600V/cm is kept unchanged in the ion transfer tube); the peak of the triethyl phosphate monomer ion is 67pA, and the resolving power is 38; the triethylphosphate monomer ion peak was 39pA with a resolution of 37. Clearly, both the peak height and the resolving power of the ion peaks of the triethylphosphate product were lower than in fig. 3 a.
Comparative example 2
In order to compare the performance of the time domain electric field enhanced ion transfer tube disclosed by the invention, the output value of a power supply is increased to 4400V to form an initial transfer electric field of 800V/cm in the transfer tube, and the response spectrum of 50ppb triethylphosphate when the ion gate opening time is 0.05ms is shown as a graph in fig. 3c, wherein an acetone ion peak is 540pA and the resolving power is 58; the peak of the triethyl phosphate monomer ion is 146pA, and the resolution capability is 62; the peak of the triethylphosphate monomer ion was 76pA and the resolving power was 60. Although the peak height and resolution of the triethylphosphate product ion peak in this experiment was comparable to that in fig. 3a, the high voltage power output 4400V used in this experiment was significantly higher than the high voltage power output 3300V used in fig. 3 a.
Claims (6)
1. The ion migration tube is a hollow columnar cavity formed by sequentially alternately and coaxially overlapping an annular conductive pole piece (6) and an annular insulating pole piece (7); an ion source (1) and an ion receiving electrode (5) are respectively arranged at two ends of the cavity; an ion gate (3) is arranged between the ion source (1) and the ion receiving electrode (5) in the cavity to divide the interior of the cavity into two areas, wherein an ionization area (2) is formed between the ion source (1) and the ion gate (3), and a migration area (4) is formed between the ion gate (3) and the ion receiving electrode (5); the method is characterized in that:
the ion source (1), the annular conductive pole piece (6), the ion gate (3) and the ion receiving pole (5) are sequentially connected in series through the divider resistor (8), the ion source (1) is connected with a high-voltage output terminal of a direct-current high-voltage power supply, and the ion receiving pole (5) is grounded to form electric connection, so that an initial migration electric field is formed in the ion migration tube;
the ionization region (2) is composed of M+1 annular conductive pole pieces (6) and M annular insulating pole pieces (7); m is a positive integer greater than or equal to 3; two adjacent annular conductive pole pieces in the ionization region (2) are connected through the optocoupler switch (9), namely M+1 annular conductive pole pieces are connected in series through the M optocoupler switches (9) in sequence.
2. The ion transfer tube of claim 1, wherein:
the ionization region (2) is composed of M+1 annular conductive pole pieces (6) and M annular insulating pole pieces (7); m is a positive integer greater than or equal to 3; two adjacent annular conductive pole pieces in the ionization region (2) are connected through an optocoupler switch (9), namely, along the direction from the ion source (1) to the ion gate (3), the first annular conductive pole piece and the second annular conductive pole piece of the ionization region (2) are connected with the first optocoupler switch, the second annular conductive pole piece and the third annular conductive pole piece are connected with the second optocoupler switch, the M-1 th annular conductive pole piece and the M-1 th annular conductive pole piece are connected with the M-1 th optocoupler switch, and the M-1 th annular conductive pole piece and the M+1 th annular conductive pole piece are connected with the M-th optocoupler switch;
at the zeroth preset time interval t 0 In, the first optical coupler switch and the second optical coupler switchThe method comprises the steps that an M-1 optical coupler switch and an M optical coupler switch are in an off state, an initial migration electric field is maintained in a migration zone (4), an ion gate (3) is opened, and ions in an ionization zone (2) enter the migration zone (4) through the ion gate (3) to form ion groups;
at a first preset time interval t 1 The first optocoupler switch is in an on state, the second optocoupler switch, the third optocoupler switch and the M-1 optocoupler switch are in an off state, the ion gate (3) is closed, a first migration electric field with enhanced strength is formed in the migration area (4), ions in the ionization area (2) are blocked at the ion gate (3), the ion groups in the migration area (4) are compressed for the first time under the action of the first migration electric field, and the ion current density is enhanced for the first time; at a second preset time interval t 2 The first optocoupler switch and the second optocoupler switch are in an on state, the third optocoupler switch, the M-1 optocoupler switch and the M-1 optocoupler switch are in an off state, the ion gate (3) is closed, a second migration electric field with enhanced strength is formed in the migration area (4), the ion groups in the migration area (4) are compressed for the second time under the action of the second migration electric field, and the ion current density is enhanced for the second time; … …; at the M-1 th preset time interval t m-1 The first optocoupler switch, the second optocoupler switch, the M-2 optocoupler switch and the M-1 optocoupler switch are in an on state, the M-2 optocoupler switch is in an off state, the ion gate (3) is closed, an M-1 migration electric field with enhanced strength is formed in the migration area (4), the ion groups in the migration area (4) are compressed for the M-1 time under the action of the M-1 migration electric field, and the ion current density is enhanced for the M-1 time; at the M-th preset time interval t m The first optocoupler switch, the second optocoupler switch, the M-1 optocoupler switch and the M optocoupler switch are in a conducting state, the ion gate (3) is closed, an Mth migration electric field with enhanced strength is formed in the migration area (4), the ion groups in the migration area (4) are compressed for the Mth time under the action of the Mth migration electric field, the ion current density is enhanced for the Mth time and finally received by the ion receiving electrode (5), and an ion migration spectrogram with ultra-high resolution capability and ultra-high sensitivity is formed;
the intensity of the Mth migration electric field is higher than that of the Mth-1 migration electric field, the intensity of the Mth-1 migration electric field is higher than that of the Mth-2 migration electric field, … …, the intensity of the second migration electric field is higher than that of the first migration electric field, and the intensity of the first migration electric field is higher than that of the initial migration electric field.
3. The ion transfer tube of claim 1 or 2, wherein:
the initial, first, second, … …, M-1 and M-th transfer electric fields satisfy E/N between greater than 0 and less than or equal to 4Td, where E represents electric field strength and N represents gas molecular number density.
4. The ion transfer tube of claim 1, wherein: a drift gas inlet (10) is arranged on the side wall of the migration zone (4) close to one end of the ion receiving electrode (5), and a sample gas inlet (11) and a tail gas outlet (12) are arranged on the side wall of the ionization zone (2) close to one end of the ion source (1).
5. The ion transfer tube of claim 1, wherein: the ion gate is any one of a Bradbury-Neilson type ion gate and a Tyndall-Powell type ion gate;
the ion source is any ion source capable of ionizing sample gas molecules under atmospheric pressure.
6. The ion transfer tube of claim 2, wherein: zeroth preset time interval t 0 First preset time interval t 1 A second preset time interval t 2 … …, mth-1 preset time interval t m-1 With the M preset time interval t m Constitutes a complete working cycle of the ion gate (3), according to which the ion gate (3) is cyclically operated.
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| US9147565B1 (en) * | 2014-12-30 | 2015-09-29 | Morpho Detection, Llc | Ion mobility spectrometer and method of using the same |
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| US9147565B1 (en) * | 2014-12-30 | 2015-09-29 | Morpho Detection, Llc | Ion mobility spectrometer and method of using the same |
| CN108091537A (en) * | 2016-11-21 | 2018-05-29 | 中国科学院大连化学物理研究所 | A kind of ladder Field ion mobility pipe |
| CN108091536A (en) * | 2016-11-21 | 2018-05-29 | 中国科学院大连化学物理研究所 | A kind of pulsed field transference tube |
| CN213583698U (en) * | 2020-11-24 | 2021-06-29 | 中国科学院大连化学物理研究所 | Time domain enhanced ion migration tube |
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