CN112473026A - Immune system regulation and control method and ultrasonic immunotherapy device - Google Patents
Immune system regulation and control method and ultrasonic immunotherapy device Download PDFInfo
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- 238000009169 immunotherapy Methods 0.000 title claims abstract description 32
- 230000033228 biological regulation Effects 0.000 title claims abstract description 31
- 210000000987 immune system Anatomy 0.000 title claims abstract description 29
- 238000000034 method Methods 0.000 title claims abstract description 29
- 210000000056 organ Anatomy 0.000 claims abstract description 5
- 230000003213 activating effect Effects 0.000 claims abstract description 4
- 230000001105 regulatory effect Effects 0.000 claims abstract description 3
- 230000000638 stimulation Effects 0.000 claims description 19
- 238000002604 ultrasonography Methods 0.000 claims description 14
- 238000012545 processing Methods 0.000 claims description 12
- 230000003321 amplification Effects 0.000 claims description 10
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 230000001900 immune effect Effects 0.000 claims description 6
- 210000004556 brain Anatomy 0.000 claims description 4
- 230000000694 effects Effects 0.000 claims description 4
- 230000005764 inhibitory process Effects 0.000 claims description 4
- 239000007822 coupling agent Substances 0.000 claims description 3
- 239000008367 deionised water Substances 0.000 claims description 3
- 229910021641 deionized water Inorganic materials 0.000 claims description 3
- 230000001276 controlling effect Effects 0.000 claims description 2
- 230000003832 immune regulation Effects 0.000 claims 1
- 210000000653 nervous system Anatomy 0.000 abstract description 9
- 201000010099 disease Diseases 0.000 abstract description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 6
- 230000001629 suppression Effects 0.000 abstract description 5
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- 230000005934 immune activation Effects 0.000 abstract description 3
- 230000002401 inhibitory effect Effects 0.000 abstract description 3
- 210000005036 nerve Anatomy 0.000 abstract description 2
- 206010028980 Neoplasm Diseases 0.000 description 4
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- 238000010586 diagram Methods 0.000 description 3
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- 108091008028 Immune checkpoint receptors Proteins 0.000 description 1
- 102000037984 Inhibitory immune checkpoint proteins Human genes 0.000 description 1
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N7/02—Localised ultrasound hyperthermia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0004—Applications of ultrasound therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0004—Applications of ultrasound therapy
- A61N2007/0021—Neural system treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0078—Ultrasound therapy with multiple treatment transducers
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- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Abstract
The invention belongs to the technical field of immunotherapy devices, and particularly relates to an immune system regulation and control method and an ultrasonic immunotherapy device. The immune system regulating method provided by the invention comprises the steps of generating ultrasonic waves with specific parameters, conducting the ultrasonic waves to target human tissues and organs, activating or inhibiting the ultrasonic waves and the like. The invention also provides a device structure for realizing the immune system regulation and control. The invention aims at different immune nervous systems, generates specific ultrasonic waves, guides the ultrasonic waves to a nerve nucleus of a target nervous system, stimulates a central or peripheral system, generates an immune activation or suppression effect and achieves the aim of immunotherapy of diseases.
Description
Technical Field
The invention belongs to the technical field of immunotherapy devices, and particularly relates to an immune system regulation and control method and an ultrasonic immunotherapy device.
Background
"cancer immunotherapy" was evaluated as the best scientific breakthrough in 2013 by the academic journals of various universities, and two scientists who proposed tumor immunotherapy were awarded the nobel physiology or medical prize in 2018. Immunotherapy aims at treating diseases by raising or suppressing the immune system of the patient himself.
The current immunotherapy method is drug therapy, such as the more reported researches on two tumor immunotherapy methods (immune checkpoint blockade therapy and chimeric antigen receptor T cell therapy) at present, and foreign substances (immune checkpoint inhibitors and receptors) are added to realize the recognition and attack of immune cells on cancer cells. The drugs used in the treatment methods not only have long development period and high cost, but also bring huge economic burden to patients in the treatment process.
Ultrasonic focusing therapy is a brand new treatment mode, and the application of the technology is already reported in some disease treatment fields. However, there is no report on the application of ultrasound technology to the regulation of the immune system to achieve the goal of pre-treatment of diseases such as cancer.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention provides an immune system regulation and control method and an ultrasonic immunotherapy device by developing and improving the prior ultrasonic imaging system and combining the immunotherapy theory, and the immune system regulation and control method and the ultrasonic immunotherapy device can be rapidly put into use, have low manufacturing cost and greatly reduce the treatment cost of patients.
The method is realized by the following technical scheme:
an immune system modulation method for modulating the immune system, the immune system modulation method comprising:
s01: adjusting ultrasonic parameters according to the regulation and control purpose of the immune system, and generating and transmitting ultrasonic waves;
s02: directionally adjusting the conduction direction of the ultrasonic waves according to the position and the area of the target spot;
s03: the ultrasonic waves are focused and transmitted to a target point.
Specifically, the immunoregulation aims at activating an immune effect or suppressing an immune effect.
Specifically, the target site of interest is a brain or an immune organ.
Specifically, in step S03, a coupling agent or deionized water is used for conduction.
An ultrasonic immunotherapy device comprising:
the ultrasonic electronic phased array module is used for generating a specific electric pulse signal according to the regulation and control purpose of the immune system so as to regulate ultrasonic parameters;
the ultrasonic area array generator is used for generating and transmitting ultrasonic waves according to the ultrasonic wave parameters set by the ultrasonic electronic phased array module;
and the guiding and fixing module is used for fixing the ultrasonic area array generator so as to guide and focus the ultrasonic waves to be emitted to a target point.
Furthermore, the ultrasonic immunotherapy device further comprises a data processing unit, wherein the data processing unit is used for analyzing the activation or inhibition effect of the parameters of the specific pulse waveform on the target point, and sending a waveform adjusting instruction to the ultrasonic phased array module according to the activation or inhibition effect so as to adjust the parameters of the specific pulse waveform.
Specifically, the ultrasonic electronic phased array module includes:
the signal transmitting circuit is used for generating an electric pulse signal with a specific pulse waveform;
the power amplification circuit is electrically connected with the signal transmitting circuit and is used for carrying out power amplification on the electric pulse signal with the specific pulse waveform;
the electronic phase control circuit is electrically connected with the data processing unit, the signal transmitting circuit and the power amplifying circuit and is used for processing the electric pulse signals after power amplification into electric pulse signals with preset depth and a preset number of focusing focal domains and controlling the signal transmitting circuit to adjust parameters of the specific pulse waveform;
and the impedance matching circuit is electrically connected with the ultrasonic area array generator and the electronic phased circuit and is used for performing impedance matching with the ultrasonic area array generator and triggering the ultrasonic area array generator to convert the electric pulse signal into ultrasonic waves with a preset focusing range and a preset frequency range.
Specifically, the ultrasonic area array generator comprises a backing block, a piezoelectric element, a matching layer and an acoustic lens which are sequentially connected and arranged, and is electrically connected with the ultrasonic electronic phased array module through a cable; the number of the piezoelectric elements is multiple, and the piezoelectric elements form an array.
Specifically, the guide fixing module comprises a fixing support, a collimator, a water bag and a circulating water module.
The invention provides an immune system regulation method, which aims at different immune tissues or organs, generates specific ultrasonic waves, guides the ultrasonic waves to a target point of a target nervous system, stimulates a central or peripheral system, generates an immune activation or suppression effect and achieves the aim of immunotherapy of diseases.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed to be used in the description of the embodiments are briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts.
FIG. 1 is a flow chart of a method of modulating the immune system provided in the examples herein;
FIG. 2 is a schematic structural diagram of an ultrasound immunotherapy device provided in an embodiment of the present application;
FIG. 3 is another schematic view of an ultrasound immunotherapy apparatus provided in an embodiment of the present application;
fig. 4 is a schematic structural diagram of an ultrasound electronic phased array module of an ultrasound immunotherapy apparatus provided in an embodiment of the present application.
Fig. 5 is a schematic structural diagram of an ultrasonic area array generator of an ultrasonic immunotherapy device provided in an embodiment of the present application.
Reference numerals:
the ultrasonic acoustic wave device comprises a 1-ultrasonic electronic phased array module, a 2-ultrasonic area array generator, a 3-guiding fixing module, a 4-data processing unit, 101-a signal transmitting circuit, 102-a power amplifying circuit, 103-an electronic phased circuit, 104-an impedance matching circuit, 201-a backing block, 202-a piezoelectric element, 203-a matching layer and 204-an acoustic lens.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The present embodiment provides an immune system regulation method, which can emit specific ultrasonic waves to target functional regions of central nerves or peripheral nerves, activate/inhibit the nervous system (central/peripheral) by non-invasive low-energy ultrasonic waves, so as to achieve the purpose of immunotherapy,
the immune system regulation method comprises the following steps:
s01: according to the regulation and control purpose of the immune system, the ultrasonic wave parameters are adjusted, and ultrasonic waves are generated and emitted.
Specifically, the immunoregulation aims at activating an immune effect or suppressing an immune effect. The target nervous system location is a brain or an immune organ.
S02: and directionally adjusting the conduction direction of the ultrasonic waves according to the position and the area of the target point.
In application, the ultrasonic focusing position is adjusted according to the position change information of the target point, so that the adjusted ultrasonic focusing position and the target point are achieved. Further, ultrasound stimulation and therapy may be performed using ultrasound waves directed toward a focal position, producing an ultrasound focal spot.
S03: the ultrasonic waves are focused and transmitted to a target point.
In application, errors caused by focusing focal domain motion can be corrected in real time in the ultrasonic stimulation regulation and control process, the ultrasonic field reaches a target point through dynamic regulation, and ultrasonic stimulation is carried out on the target point, so that real-time and accurate ultrasonic stimulation of a point to be stimulated can be ensured, and self-adaptive ultrasonic stimulation is realized. Specifically, in step S03, a coupling agent or deionized water may be used for conduction.
The implementation also provides an ultrasonic immunotherapy device for realizing the regulation and control method.
As shown in fig. 2, the ultrasonic immunotherapy apparatus includes:
the ultrasonic electronic phased array module 1 is used for generating specific electric pulse signals according to the regulation and control purpose of an immune system so as to regulate ultrasonic parameters;
the ultrasonic area array generator 2 is used for generating and transmitting ultrasonic waves according to the ultrasonic wave parameters set by the ultrasonic electronic phased array module 1;
and the guiding and fixing module 3 is used for fixing the ultrasonic area array generator 2 so as to guide and focus the ultrasonic waves to be emitted to a target point.
Further, the ultrasonic immunotherapy device further comprises a data processing unit 4, wherein the data processing unit 4 is configured to analyze the activation and suppression effect of the parameters of the specific pulse waveform on the target point, and send a waveform adjustment instruction to the ultrasonic phased array module 1 according to the activation and suppression effect, so as to adjust the parameters of the specific pulse waveform.
The ultrasonic electronic phased array module 1 is realized based on an ultrasonic phased array technology. For example, the ultrasound phased array module may include, but is not limited to, signal transmission circuitry, power amplification circuitry, electronic phased circuitry, impedance matching circuitry, and the like. Specifically, the ultrasonic electronic phased array module includes:
a signal transmitting circuit 101 for generating an electric pulse signal of a specific pulse waveform;
a power amplification circuit 102 electrically connected to the signal transmission circuit 101, for performing power amplification on the electric pulse signal of the specific pulse waveform;
the electronic phase control circuit 103 is electrically connected with the data processing unit 4, the signal transmitting circuit 101 and the power amplifying circuit 102, and is configured to process the electric pulse signals after power amplification into electric pulse signals with a preset depth and a preset number of focusing focal domains, and control the signal transmitting circuit to adjust parameters of the specific pulse waveform;
and the impedance matching circuit 104 is electrically connected with the ultrasonic area array generator 2 and the electronic phased circuit 103, and is used for performing impedance matching with the ultrasonic area array generator 2 and triggering the ultrasonic area array generator 2 to convert the electric pulse signal into an ultrasonic wave with a preset focusing range and a preset frequency range.
In application, the preset focus range may be set according to the area of a specific functional area of the brain that requires intervention and treatment. The preset focus range is less than or equal to the area of the specific functional area requiring intervention and treatment. The predetermined frequency range may be set within a frequency range that can exert excitatory or inhibitory effects on the specific functional region requiring intervention or treatment, but does not cause damage to the specific functional region.
In application, the parameters of a particular electrical pulse signal include pulse strength, pulse frequency, pulse repetition frequency, pulse amplitude, pulse width (or pulse length), pulse duration, and duty cycle (or pulse interval). The initial values of the parameters of the specific electrical pulse signals can be set according to the excitatory and inhibitory effects of the specific electrical pulse signals with different parameters on the specific functional area of the target nervous system.
In application, the preset depth may be set according to the depth of a specific functional region in the target nervous system that needs to be stimulated. The preset depth is equal to the depth of a specific functional area needing stimulation regulation.
In application, the preset number can be set according to the number of specific functional regions in the target nervous system, which need stimulation regulation. When the preset number is equal to the number of the specific functional regions to be stimulated and regulated, the ultrasonic waves obtained by converting the electric pulse signals can form a focusing focal region at the position of each specific functional region, so that the simultaneous stimulation and regulation of all the specific functional regions are realized; when the preset number is smaller than the number of the specific functional regions needing stimulation regulation, the ultrasonic waves can form a focusing focal region at each specific functional region position in the preset number of specific functional regions respectively, so that simultaneous stimulation regulation of the preset number of specific functional regions is realized, after stimulation regulation of the preset number of specific functional regions is completed, the ultrasonic waves can be focused to the preset number of other specific functional regions for stimulation regulation, and thus batch stimulation regulation of all the specific functional regions can be realized.
Specifically, the ultrasonic area array generator comprises a backing block 201, a piezoelectric element 202, a matching layer 203 and an acoustic lens 204 which are sequentially connected, and is electrically connected with the ultrasonic electronic phased array module 1 through a cable; the piezoelectric elements 202 are plural in number and constitute an array.
Specifically, the guiding and fixing module 3 is configured to adjust parameter information of the ultrasonic wave according to a position and an area of the target point, so as to change a conduction direction of the ultrasonic wave and perform directional conduction, and enable an ultrasonic focal spot focused by the ultrasonic wave to be projected on the target point.
Specifically, the guiding and fixing module 3 may include a fixing bracket, a collimator, a water bag, and a circulating water module.
The guide fixing module 3 can correct errors caused by focusing focal domain motion in real time in the ultrasonic stimulation regulation and control process, and the ultrasonic field reaches a target point through dynamic regulation, so that ultrasonic stimulation is carried out on the target point, the fact that a point to be stimulated is subjected to real-time and accurate ultrasonic stimulation can be guaranteed, and self-adaptive ultrasonic stimulation is achieved.
The invention provides an immune system regulation and control method, which aims at different immune nervous systems, generates specific ultrasonic waves, guides the ultrasonic waves to a target spot, stimulates a central or peripheral system, generates an immune activation or suppression effect and achieves the aim of immunotherapy of diseases.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (10)
1. An immune system modulation method for modulating the immune system, the immune system modulation method comprising:
s01: adjusting ultrasonic parameters according to the regulation and control purpose of the immune system, and generating and transmitting ultrasonic waves;
s02: directionally adjusting the conduction direction of the ultrasonic waves according to the position and the area of the target spot;
s03: the ultrasonic waves are focused and transmitted to a target point.
2. The method for regulating the immune system according to claim 1, wherein the immune regulation is aimed at activating an immune effect or suppressing an immune effect.
3. The method of claim 1, wherein the target site of interest is a brain or an immune organ.
4. The method of claim 1, wherein the step S03 is conducted with coupling agent or deionized water.
5. An ultrasound immunotherapy device for carrying out the immune system modulation method of any one of claims 1-4, comprising:
the ultrasonic electronic phased array module is used for generating a specific electric pulse signal according to the regulation and control purpose of the immune system so as to regulate ultrasonic parameters;
the ultrasonic area array generator is used for generating and transmitting ultrasonic waves according to the ultrasonic wave parameters set by the ultrasonic electronic phased array module;
and the guiding and fixing module is used for fixing the ultrasonic area array generator so as to guide and focus the ultrasonic waves to be emitted to a target point.
6. The ultrasound immunotherapy device of claim 5, further comprising a data processing unit, wherein the data processing unit is configured to analyze the stimulation and inhibition effects of the parameters of the specific pulse waveform on the target point, and send a waveform adjusting command to the ultrasound phased array module according to the stimulation and inhibition effects to adjust the parameters of the specific pulse waveform.
7. The ultrasound immunotherapy apparatus of claim 6, wherein the ultrasound electronic phased array module comprises:
the signal transmitting circuit is used for generating an electric pulse signal with a specific pulse waveform;
the power amplification circuit is electrically connected with the signal transmitting circuit and is used for carrying out power amplification on the electric pulse signal with the specific pulse waveform;
the electronic phase control circuit is electrically connected with the data processing unit, the signal transmitting circuit and the power amplifying circuit and is used for processing the electric pulse signals subjected to power amplification into electric pulse signals with preset depth and preset number of focusing focal domains and controlling the signal transmitting circuit to adjust parameters of the specific pulse waveform;
and the impedance matching circuit is electrically connected with the ultrasonic area array generator and the electronic phased circuit and is used for performing impedance matching with the ultrasonic area array generator and triggering the ultrasonic area array generator to convert the electric pulse signal into ultrasonic waves with a preset focusing range and a preset frequency range.
8. The ultrasonic immunotherapy device of claim 5, wherein the ultrasonic area array generator comprises a backing block, a piezoelectric element, a matching layer, and an acoustic lens, which are connected in sequence, and are electrically connected with the ultrasonic electronic phased array module through a cable.
9. The ultrasonic immunotherapy apparatus according to claim 8, wherein the piezoelectric elements are plural in number and constitute an array.
10. The ultrasonic immunotherapy device of claim 5, wherein the guidance fixture module comprises a fixture bracket, a collimator, a water bladder, and a circulating water module.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1215616A (en) * | 1998-01-25 | 1999-05-05 | 重庆医科大学附属第二医院 | High-intensity focus supersonic tumor scanning therapy system |
| CN103143125A (en) * | 2013-03-25 | 2013-06-12 | 广州多浦乐电子科技有限公司 | High-strength focusing ultrasonic therapeutic apparatus |
| US20170203131A1 (en) * | 2016-01-19 | 2017-07-20 | SonaCare Medical, LLC | HIFU And Immune System Activation |
| CN110478631A (en) * | 2019-08-15 | 2019-11-22 | 深圳先进技术研究院 | A kind of apparatus for ultrasonic therapeutic treatment, method and data processing equipment |
| CN111790066A (en) * | 2020-07-13 | 2020-10-20 | 陈锦华 | Frequency-amplitude-adjustable tumor ultrasonic diagnosis and treatment system |
-
2020
- 2020-12-11 CN CN202011452968.XA patent/CN112473026A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1215616A (en) * | 1998-01-25 | 1999-05-05 | 重庆医科大学附属第二医院 | High-intensity focus supersonic tumor scanning therapy system |
| CN103143125A (en) * | 2013-03-25 | 2013-06-12 | 广州多浦乐电子科技有限公司 | High-strength focusing ultrasonic therapeutic apparatus |
| US20170203131A1 (en) * | 2016-01-19 | 2017-07-20 | SonaCare Medical, LLC | HIFU And Immune System Activation |
| CN110478631A (en) * | 2019-08-15 | 2019-11-22 | 深圳先进技术研究院 | A kind of apparatus for ultrasonic therapeutic treatment, method and data processing equipment |
| CN111790066A (en) * | 2020-07-13 | 2020-10-20 | 陈锦华 | Frequency-amplitude-adjustable tumor ultrasonic diagnosis and treatment system |
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