CN112449597A - Liquid composition for skin cleansing - Google Patents
Liquid composition for skin cleansing Download PDFInfo
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- CN112449597A CN112449597A CN202080003387.XA CN202080003387A CN112449597A CN 112449597 A CN112449597 A CN 112449597A CN 202080003387 A CN202080003387 A CN 202080003387A CN 112449597 A CN112449597 A CN 112449597A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/596—Mixtures of surface active compounds
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Abstract
The purpose of the present invention is to provide a liquid composition for skin cleansing which is used in a method different from the conventional methods. A liquid composition for skin cleansing which contains (A) a surfactant derived from a natural source and (B) an amphipathic ester and which is stored in a spray container, and which can exhibit excellent cleansing power while reducing skin irritation of the liquid composition for skin cleansing, and therefore can provide a new use in which the liquid composition for skin cleansing is directly sprayed onto the skin and applied to the skin, unlike the conventional use in which the liquid composition for skin cleansing is previously foamed when applied to the skin.
Description
Technical Field
The present invention relates to a liquid composition for skin cleansing which can be cleansed without applying physical friction to the skin.
Background
Various skin cleansing compositions such as facial cleanser, body soap, and shampoo are provided as products for the purpose of cleansing the skin and keeping the skin clean. In the mechanism of skin cleansing by the skin cleanser composition, the surfactant adsorbs to the dirt to reduce the surface tension between the dirt and water, and mechanical force due to friction also interacts with each other to float the dirt in water. In order to effectively exert such a cleaning mechanism, it is necessary to incorporate a surfactant at a critical micelle concentration or higher.
On the other hand, the cleansing power by the surfactant is too strong and causes skin irritation, and as a result, there is a current situation in which a skin problem typified by dry skin is caused. Therefore, various formulations for studying combinations of cleansing components, blending amounts, and the like have been proposed for the purpose of moderating the action on the skin. Among them, it is common knowledge that a formulation for improving the quality of foam such as foaming power and foam retention is excellent as a formulation for moderating the action on the skin because the foam formed during washing can reduce the friction caused by direct contact between the skin and fingers.
Therefore, in recent years, various pump foamer type skin cleansers have been proposed, which not only can easily obtain good quality foam, but also attract attention to the softness of the skin. Specifically, patent document 1 discloses a liquid skin cleansing composition comprising a foam container (Japanese original: フォーマー container) and a liquid skin cleansing composition filled in the foam container, wherein the liquid skin cleansing composition comprises (A) 3 to 10% by mass of a specific fatty acid salt having a linear or branched monovalent hydrocarbon group having 7 to 21 carbon atoms, (B) a copolymer of a specific dimethyldiallylammonium chloride and acrylic acid and/or acrylamide, and (C) a sugar alcohol, and the mass ratio (A)/(B) of the content of component (A) to the content of component (B) is 20 to 250. Patent document 2 discloses a skin cleansing composition comprising a cleansing agent filled in a foam container, wherein the cleansing agent comprises 2 to 9 mass% of a fatty acid salt (a), 0.5 to 4 mass% of lauryl dimethyl glycine betaine (b), and 1 to 10 mass% of one or more glycols (c), wherein the sum of the amounts (mass%) of a component (a) and a component (b) is 3 to 10 mass%, and the ratio (b)/(a) is 0.1 to 0.5. Further, patent document 3 discloses a detergent composition containing 4 to 15 mass% of a higher fatty acid soap (a) composed of lauryl dimethyl glycine betaine and (b) a fatty acid having 5 to 25 carbon atoms and having a specific composition, and being discharged from a foamer container.
On the other hand, a detergent composition using a biodegradable natural surfactant is also known in consideration of environmental load. For example, patent document 4 discloses a cleaning agent composition in which 11 to 45 parts by weight of a natural surfactant, 25 to 35 parts by weight of mirabilite, 10 to 40 parts by weight of a hard water softener, 0.1 to 5 parts by weight of a chelating agent, and the balance of additional cleaning agent raw materials add up to 100 parts by weight.
Documents of the prior art
Patent document
Patent document 1: international publication No. 2014/003114
Patent document 2: japanese patent laid-open publication No. 2016-098182
Patent document 3: international publication No. 2017/081897
Patent document 4: japanese patent laid-open No. 2014-051544
Disclosure of Invention
Problems to be solved by the invention
In view of the fact that the amount of the surfactant to be added is relatively small, the pump-foamer type skin cleanser composition tends to cause less irritation to the skin than the solid or semisolid skin cleanser composition. On the other hand, since it is a big premise that the pump foamer type skin cleanser composition is discharged in a state of foam, it is inevitable to add a minimum amount of surfactant necessary for exerting foaming power to the composition.
In addition, various skin cleansing materials have been created for the purpose of removing body fluids such as sebum and sweat, dirt, and the like, in addition to skin cleansing materials for the purpose of cleansing (cleansing), but it is common knowledge that any skin cleansing material, including pump-foamer type skin cleansing materials and natural surfactant-containing skin cleansing materials, is not exceptional, and foaming is preferred before application to the skin, and further, good foaming is preferred from the viewpoint of moderation of friction against the skin, as well. Although the foam can alleviate physical friction by being interposed between the skin and the hand, the foam itself generates physical friction by rubbing against the skin, and causes irritation to the skin, which is not changed. In this way, in the same use method as in the conventional art, the reduction of the burden on the skin by the skin cleansing material is limited.
In addition, in beauty salons and beauty parlors, washing operations of faces and the like are sometimes performed, and a washing operation that is gentle to the skin is desired in order to improve the quality of service.
Accordingly, an object of the present invention is to provide a liquid composition for skin cleansing which can be cleansed without applying physical friction to the skin.
Means for solving the problems
The present inventors have conceived of a novel use in which a liquid composition for skin cleansing is applied directly to the skin without causing a preliminary lather when applied to the skin, and the skin is cleansed without applying physical friction to the skin, in order to further reduce irritation to the skin. Further, it has been found that, in order to further reduce the irritation to the skin, a surfactant derived from a natural source is blended so that the blending amount thereof is greatly reduced as compared with the blending amount contained in a conventional skin cleanser composition. In the skin cleanser composition containing only such a small amount of surfactant, the cleansing power cannot be obtained at the cost of reduced irritation to the skin, but by allowing the amphiphilic ester to coexist, the cleansing power can be effectively obtained without applying physical friction to the skin. The present invention has been completed through further repeated studies based on this finding.
That is, the present invention provides the inventions of the embodiments disclosed below.
Item 1. A liquid composition for skin cleansing comprising (A) a surfactant derived from a natural source and (B) an amphiphilic ester,
the content of the (A) is 0.025-2 wt%,
the liquid composition for skin cleansing is used for cleansing without applying physical friction to the skin.
Item 2 the liquid composition for skin cleansing according to item 1, wherein the (B) component is selected from the group consisting of bis (polyoxyalkylene alkyl ether) dicarboxylate, dialkoxyalkyl dicarboxylate, and polyglycerol-10 eicosadioate/tetradecadioate.
Item 3. the liquid composition for skin cleansing according to item 2, wherein the dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester is bis-diethoxydiethylene glycol cyclohexane 1, 4-dicarboxylate.
Item 4 the liquid composition for skin cleansing according to any one of items 1 to 3, wherein the component (A) is selected from the group consisting of glycerophospholipids, saponins, and lipopeptides.
Item 5. the liquid composition for skin cleansing according to item 4, wherein the glycerophospholipid is selected from the group consisting of lecithin, lysolecithin, and hydrogenated lecithin.
Item 6. the liquid composition for skin cleansing according to item 4, wherein the lipopeptide is selected from the group consisting of surfactin and salts thereof.
A method of skin cleansing, comprising:
a liquid composition for skin cleansing, which contains (A) a surfactant derived from a natural source and (B) an amphiphilic ester, wherein the content of (A) is 0.025-2 wt%, is applied to the skin without applying physical friction to the skin.
ADVANTAGEOUS EFFECTS OF INVENTION
According to the liquid composition for skin cleansing of the present invention, since excellent cleansing power can be exhibited while skin irritation is reduced, cleansing can be performed without foaming in advance and without physical friction on the skin when applied to the skin. Since the skin can be washed without physically rubbing the skin, the amount of the surfactant to be added to the liquid composition for skin washing can be significantly reduced as compared with the amount to be added to a conventional liquid composition for skin washing, and thus the skin irritation can be further reduced.
Detailed Description
1. Liquid composition for skin cleansing
The liquid composition for skin cleansing of the present invention is characterized by containing a surfactant (hereinafter, sometimes referred to as component (a)) derived from natural sources and an amphiphilic ester (hereinafter, sometimes referred to as component (B)) in predetermined amounts. The liquid composition for skin cleansing of the present invention will be described in detail below.
(A) Surfactant derived from natural sources
The liquid composition for skin cleansing of the present invention contains a surfactant derived from natural sources as the component (a). Surfactants derived from natural sources are substances of biological origin and having a surface-active action.
The surfactant derived from natural sources used in the present invention is not particularly limited, and examples thereof include natural products extracted and purified from animals, plants, or microorganisms; substances synthesized by microbiological culture, substances synthesized by genetic engineering, and substances synthesized by chemical synthesis of these natural products; and those obtained by subjecting these natural products to a hydrogenation treatment, a hydroxylation treatment, a hydrolysis treatment, or the like.
Examples of the naturally-derived surfactant used in the present invention include phospholipids, saponins, lipopeptides, cholesterol, bile acids, and the like. These surfactants derived from natural sources may be used alone or in combination of two or more. Among these surfactants derived from natural sources, preferred examples include phospholipids, saponins, and lipopeptides.
The phospholipid may be glycerophospholipid, sphingomyelin, or the like. Glycerophospholipids are substances having a glycerophosphate skeleton and having lipophilic groups such as fatty acid esters, long-chain alkyl ethers, and vinyl ethers. Specific examples of glycerophospholipids include phosphatidylcholine (lecithin), phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol polyphosphate, diphosphatidylglycerol (cardiolipin), phosphatidic acid, and hydrogenated, hydroxylated, and hydrolyzed products thereof. Sphingomyelin is a phosphoric acid or phosphonic acid derivative of a long-chain base or a long-chain fatty acid, such as sphingosine or phytosphingosine. Specific examples of sphingomyelin include ceramide 1-phosphate derivatives (sphingomyelin, etc.) and ceramide 1-phosphonate derivatives (ceramide aminoethyl phosphonic acid, etc.). These phospholipids may be used alone or in combination of two or more.
Among these phospholipids, preferred examples include glycerophospholipids, more preferred examples include lecithins (soybean lecithin, egg yolk lecithin), hydrogenated lecithins, hydroxylated lecithins, and lysolecithins, and further preferred examples include lecithins (soybean lecithin, egg yolk lecithin, and the like), hydrogenated lecithins, and lysolecithins. In addition, from the viewpoint of obtaining more excellent detergency, preferred examples include lecithin (soybean lecithin, egg yolk lecithin, and the like) and lysolecithin, and from the viewpoint of further suppressing a feeling of tightness due to skin irritation and insufficient moisture retention, preferred examples include hydrogenated lecithin.
The saponin is a glycoside composed of a sapogenin and a sugar, and specifically, a triterpene glycoside and a steroid glycoside are exemplified. Specific examples of the saponin include quillaja saponin, soyasaponin, yucca saponin, sophorae saponin, beet saponin, phaseoloside, ginsenoside, theasaponin, luffa saponin, asiaticoside, and the like. These saponins may be used alone or in combination of two or more.
Lipopeptides are lipidated peptides, and specific examples thereof include surfactin, desmosine, iturin, and salts thereof. These lipopeptides may be used singly or in combination of two or more.
Among these lipopeptides, preferred are surfactin and salts thereof, and more preferred are surfactin salts. The salt of the surfactin is a compound represented by the following formula (I).
[ chemical formula 1 ]
In the formula (I), X represents an amino acid residue selected from leucine, isoleucine and valine, and R represents C9-18Alkyl radical, M+Represents an alkali metal ion or a quaternary ammonium ion. The alkali metal ion is not particularly limited, and includes lithium ion, sodium ion, potassium ion, and the like, and preferably includes sodium ion. Examples of the substituent of the quaternary ammonium ion include alkyl groups such as methyl, ethyl, n-propyl, isopropyl, n-butyl, and tert-butyl; aralkyl groups such as benzyl, methylbenzyl, and phenylethyl; and aryl groups such as phenyl, tolyl, and xylyl. These surfactin or salts thereof may be used alone or in combination of two or more.
The content of the component (A) in the liquid composition for skin cleansing of the present invention is 0.025 to 2% by weight. By making the surfactant amount such small, the skin irritation can be significantly reduced. In the present invention, since the component (B) is present, excellent detergency can be exerted, and thus even a small amount of surfactant which cannot exert an effective detergency originally can effectively exert a detergency.
The preferable content of the component (a) is, for example, 0.5 to 2% by weight, more preferably 1 to 2% by weight, from the viewpoint of obtaining more excellent detergency, and 0.025 to 1.5% by weight, more preferably 0.025 to 1% by weight, from the viewpoint of further suppressing a feeling of tightness due to insufficient moisture retention. Further, when the component (a) is lecithin or lysolecithin, from the viewpoint of obtaining more excellent detergency, it is 0.5 to 2% by weight, from the viewpoint of further suppressing a feeling of tightness due to insufficient moisture retention, it is 0.025 to 1% by weight, and from the viewpoint of further suppressing skin irritation, it is 0.025 to 1.5% by weight. When the component (a) is a saponin, it is 1 to 2% by weight from the viewpoint of obtaining more excellent detergency.
(B) Amphiphilic esters
The liquid composition for skin cleansing of the present invention contains an amphiphilic ester as the component (B). (B) When the component (A) is used alone, the cleansing effect of the liquid composition for cleansing the skin can be improved while maintaining low irritation by allowing the component (A) to coexist in an amount of 0.025 to 2 wt%.
In the present invention, the amphiphilic ester is dissolved in ion-exchanged water having an electric conductivity adjusted to 70 to 110 μ s/m at room temperature by 2 mass% or more, and also dissolved in isotridecyl isononanoate (SALACOS 913, manufactured by riqing oitici corporation) as an oil agent at room temperature (25 ℃) by 10 mass% or more, and does not include an ester-based surfactant, in the measurement according to the method defined in the general test method of japanese pharmacopoeia.
The amphiphilic ester is not particularly limited, and is preferably an amphiphilic ester selected from the group consisting of a dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester, a dicarboxylic acid dialkoxyalkyl ester, and polyglycerol-10 eicosadipate/tetradecadipate, from the viewpoint of more satisfactory skin irritation reducing property and detergency. As the amphiphilic ester, any of dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester, dicarboxylic acid dialkoxyalkyl ester, and polyglycerol-10 eicosadipate/tetradecadipate may be used alone, or two or more thereof may be used in combination. Among these amphiphilic esters, dicarboxylic acid bis (polyoxyalkylene alkyl ether) esters are more preferable from the viewpoint of more satisfactory skin irritation reducing properties and detergency.
The dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester used in the present invention is a diester compound of a dicarboxylic acid and a polyoxyalkylene alkyl ether. Specific examples of the dicarboxylic acid constituting the diester compound such as the dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester include oxalic acid, malonic acid, succinic acid, tartaric acid, malic acid, glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid, aspartic acid, glutamic acid, acetonedicarboxylic acid, phthalic acid, cyclohexane-1, 4-dicarboxylic acid, and the like. Examples of the polyoxyalkylene alkyl ether constituting the diester compound include polyoxyethylene monoalkyl ether, and more specifically, diethylene glycol monoethyl ether and triethylene glycol monoethyl ether.
Among these dicarboxylic acid bis (polyoxyalkylene alkyl ether) esters, from the viewpoint of more satisfactory skin irritation reducing properties and detergency, preferred are diester compounds of cyclohexane-1, 4-dicarboxylic acid and diethylene glycol monoethyl ether, specifically under the INCI name (International Cosmetic Ingredient Dictionary and Handbook, 13 th edition, volume 1, CTFA, 2010, p.331): the compounds known as BIS-diethoxydibycol CYCLOHEXANE 1,4-DICARBOXYLATE and the diester compounds of succinic acid and diethylene glycol monoethyl ether described by BIS-ETHOXYDIGLYCOL cyclonexane 1,4-DICARBOXYLATE, in particular under the INCI name (International Cosmetic Ingredient Dictionary and Handbook, 13 th edition, volume 1, CTFA, 2010, p.331-332): the compound described by BIS-ETHOXYDIGLYCOL SUCCINATE is known as bisethoxydiglycol SUCCINATE.
In the present invention, specific examples of the bis-diethoxydiol cyclohexane 1,4-dicarboxylate include "neosolve-Aqulio (trade name)" manufactured by japan koku corporation. Specific examples of the bis-ethoxydiglycol succinate include "haiaqeosister DCS (trade name)" manufactured by higher alcohol industries.
These dicarboxylic acid bis (polyoxyalkylene alkyl ether) esters may be used singly or in combination of two or more.
Among these dicarboxylic acid bis (polyoxyalkylene alkyl ether) esters, bis-diethoxydiblycolcyclohexane 1,4-dicarboxylate is preferably used from the viewpoint of further suppressing the tight feeling due to insufficient moisture retention, particularly when hydrogenated lecithin or lipopeptide is used as the component (a).
The dialkoxyalkyl dicarboxylate used in the present invention is a diester compound of a dicarboxylic acid and an alkoxy alcohol. Specific examples of the dicarboxylic acid constituting the diester compound such as dialkoxyalkyl dicarboxylate include oxalic acid, malonic acid, succinic acid, tartaric acid, malic acid, glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid, aspartic acid, glutamic acid, acetonedicarboxylic acid, phthalic acid, cyclohexane-1, 4-dicarboxylic acid, and the like. Examples of the alkoxy alcohol constituting the diester compound include 2-methoxyethanol and 2-ethoxyethanol.
Among these dialkoxyalkyl dicarboxylates, a diester compound of succinic acid and 2-ethoxyethanol is preferable from the viewpoint of more favorably obtaining the effects of the present invention, and specifically diethoxyethyl succinate is exemplified.
These dialkoxyalkyl dicarboxylates may be used singly or in combination of two or more kinds.
The polyglycerol-10 eicosadioate/tetradecadioate used in the present invention is not particularly limited, and examples thereof include "neosolve-Aqua (trade name)" and "neosolve-Aqua (trade name)" manufactured by japan koku corporation.
The content of the component (B) in the liquid composition for skin cleansing of the present invention is not particularly limited, and may be, for example, 0.1% by weight or more. From the viewpoint of more satisfactory detergency and/or from the viewpoint of further reducing a tight feeling due to insufficient moisture retention, the content of the component (B) is preferably 0.5% by weight or more, more preferably 1.5% by weight or more, and still more preferably 2% by weight or more. (B) The upper limit of the range of the content of the component is not particularly limited, and from the viewpoint of stability of the spray for skin cleansing, for example, it is 5% by weight or less, preferably 4% by weight or less, and more preferably 3% by weight or less.
The ratio of the component (a) to the component (B) in the liquid composition for skin cleansing of the present invention is not particularly limited, and is determined by the above-mentioned contents, and from the viewpoint of obtaining more favorable skin irritation reducing properties and cleansing power, the component (B) is, for example, 0.1 to 100 parts by weight, preferably 1 to 80 parts by weight, based on 1 part by weight of the component (a). From the viewpoint of obtaining more excellent detergency, the component (B) is 1 to 4 parts by weight, more preferably 1 to 2 parts by weight, based on 1 part by weight of the component (a), and from the viewpoint of further suppressing a feeling of tightness due to insufficient moisture retention, 1.2 to 80 parts by weight, more preferably 2 to 80 parts by weight. Further, when the component (a) is lecithin or lysolecithin, from the viewpoint of obtaining more excellent detergency, the component (B) is 1 to 4 parts by weight relative to 1 part by weight of the component (a), from the viewpoint of further suppressing a feeling of tightness due to insufficient moisture retention, the component (B) is 2 to 80 parts by weight relative to 1 part by weight of the component (a), and from the viewpoint of further suppressing skin irritation, the component (B) is 1.2 to 80 parts by weight relative to 1 part by weight of the component (a). When the component (a) is a saponin, from the viewpoint of obtaining more excellent detergency, the component (B) is 1 to 2 parts by weight relative to 1 part by weight of the component (a).
Other ingredients
The liquid composition for skin cleansing of the present invention may contain, in addition to the above components, other necessary base agents and additives such as a preparation, within a range not impairing the effects of the present invention. Such additives are not particularly limited as long as they are pharmaceutically acceptable, and examples thereof include water, aqueous base agents such as lower alcohols having 1 to 5 carbon atoms (ethanol, isopropanol, and the like) and polyhydric alcohols (ethylene glycol, 1, 3-butanediol (1,3-BG), propylene glycol, isoprene glycol, diethylene glycol, dipropylene glycol, polypropylene glycol, and glycerin); preservatives (phenoxyethanol, methylparaben, propylparaben, benzoic acid, sodium benzoate, sorbic acid, etc.), odorants (citral, 1, 8-cineole, citronellal, farnesol, etc.), colorants (tar pigments (brown 201, blue 201, yellow 4, yellow 403, etc.), cacao pigments, chlorophyll, alumina, etc.), thickeners (hydroxypropyl cellulose, hydroxyethyl cellulose, crosslinked acrylic polymers, carboxyvinyl polymers, hydroxypropyl methyl cellulose, polyvinylpyrrolidone, sodium alginate, ethyl cellulose, carboxymethylcellulose sodium, xanthan gum, carrageenan, etc.), pH regulators (phosphoric acid, hydrochloric acid, citric acid, sodium citrate (trisodium citrate), succinic acid, tartaric acid, sodium hydroxide, potassium hydroxide, triethanolamine, triisopropanolamine, etc.), surfactants (citric acid, sodium citrate, sodium tartrate, sodium hydroxide, potassium hydroxide, triethanolamine, triisopropanolamine, etc.), etc, Wetting agents (DL-pyrrolidone carboxylic acid sodium solution, D-sorbitol solution, polyethylene glycol (Macrogol) and the like), stabilizers (dibutyl hydroxytoluene, butyl hydroxyanisole, sodium ethylene diamine tetracetate, sodium metaphosphate, L-arginine, L-aspartic acid, DL-alanine, glycine, sodium erythorbate, propyl gallate, sodium sulfite, sulfur dioxide, chlorogenic acid, catechin, rosemary extract and the like), antioxidants, ultraviolet absorbers, chelating agents, binders, buffers, dissolution aids, solubilizers, preservatives and other additives. These base materials and additives may be used singly or in combination of two or more. The contents of these base materials and additives may be appropriately set according to the form of the preparation.
In the liquid composition for skin cleansing of the present invention, other pharmacological components may be contained as necessary within a range not impairing the effects of the present invention, in addition to the above components. Examples of such pharmacological components include vitamins (e.g., vitamin a, vitamin B1, vitamin B2, vitamin B5, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin K, nicotinic acid, folic acid, biotin, lycopene, etc.), antihistamines (diphenhydramine, diphenhydramine hydrochloride, etc.), local anesthetics (procaine, tetracaine, bupivacaine, mepivacaine, chloroprocaine, proparacaine, mepivacaine or salts thereof, oxoocaine, oxicaine, oxypolyethoxydecane (oxypolyethoxyycacan) (japanese text: オキシポリエントキシデカン), scopolia liquid, dibucaine powder (japanese text: ペルカミンパーゼ), polyoxyethylene lauryl ether (japanese text: テシットデシチン), anti-inflammatory agents (indomethacin, etc.), and the like, Felbinac, diclofenac sodium, loxoprofen sodium, etc.), skin protecting agents (collodion, castor oil, etc.), blood circulation promoting components (vanillylnonanoate, benzyl nicotinate, capsaicin, capsicum extract, etc.), algefacients (menthol, camphor, borneol, peppermint water, peppermint oil, etc.), mucopolysaccharides (chondroitin sulfate sodium, glucosamine, hyaluronic acid, cationized hyaluronic acid (dihydroxypropyltrimethylammonium chloride hyaluronic acid (japanese original: ヒアルロン acid ジヒドロキシプロピルトリモニウム, etc.)) and the like. These pharmacological components may be used alone or in combination of two or more. When these pharmacological components are contained, the content thereof may be appropriately set according to the kind of the pharmacological component to be used, the desired effect, and the like.
Form of the composition
The liquid composition for skin cleansing according to the present invention is in a liquid or gel form at room temperature. The viscosity of the liquid composition for skin cleansing of the present invention is 10000mPa · s or less, preferably 5000mPa · s or less at 20 ℃. The viscosity was measured by using a BL viscometer (rotor No3, 6rpm, 20 ℃).
Container with a lid
The container for containing the liquid composition for skin cleansing of the present invention is not particularly limited as long as the liquid composition for skin cleansing can be directly applied to the skin from the inside of the container, and examples thereof include a spray type container and an injection or drip type container (particularly a cleansing bottle), and from the viewpoint of ease of handling in a beauty salon or a beauty shop, an injection or drip type container (particularly a cleansing bottle) is preferable. The spray container of the present invention is different from a pump foamer container which sprays a liquid composition for skin cleansing in a foam state, in that the contents are sprayed in a mist form.
In the present invention, by storing the liquid composition for skin cleansing in a spray type container, an injection type container or a drop type container (particularly, a cleansing bottle) in this manner, the liquid composition for skin cleansing is directly applied to the skin without causing a bubble before being applied to the skin. Therefore, application to the skin is simple and physical friction by hands or the like at the time of application and/or physical friction by bubbles at the time of washing can be avoided. As a sprayExamples of the container type include a pump type spray container which is a non-aerosol type spray container, and an aerosol type spray container. Examples of the diameter (nozzle inner diameter) of the spray container include
Preference is given to
The amount of spray per 1-time pressing when the spray container is a pump spray container is, for example, 0.05 to 1.2g, preferably 0.1 to 0.3 g.
Use of
The liquid composition for skin cleansing of the present invention is used for removing body fluids such as oil and fat and sweat from the skin, dirt, and the like, and is not used as a makeup remover (makeup remover cream). The liquid composition for skin cleansing of the present invention is used for face washing operations in beauty salons and beauty salons. The liquid composition for skin cleansing of the present invention is used by being applied directly to the skin without dilution with water or foaming. The amount of the surfactant used per 1 time depends on the concentration of the surfactant, the degree of dirt, and the like, and for example, in the case of washing face, the amount is 0.5 to 3g, preferably 1 to 2 g.
More specifically, the liquid composition for skin cleansing can be applied directly to the site to be cleansed from a spray type container, an injection or drip type container (particularly, a cleansing bottle) without taking the liquid composition for skin cleansing to the hand. In this way, by directly applying the liquid composition for skin cleansing to the site to be cleansed, it is possible to wash the site by only the mechanical force of the liquid flow without applying any physical friction such as friction between the skin of the site to be cleansed and the hands or friction between the skin of the site to be cleansed and the air bubbles. Since the liquid composition for skin cleansing of the present invention is a formulation having excellent cleansing power, by cleansing with mechanical force of a liquid flow without applying physical friction in this way, it is possible to realize an extremely excellent cleansing method capable of remarkably reducing the burden on the skin during cleansing. Such a non-foaming cleansing method enables rapid cleansing, and is also easy to feel that the skin is soft with a small amount of surfactant, and to obtain a satisfactory feeling for consumers who have high awareness of gently cleansing the skin.
The part to be washed of the liquid composition for skin washing of the present invention is not particularly limited since it can wash all body parts, and examples thereof include hands, hair, scalp, body, face, and the like. The liquid composition for skin cleansing of the present invention can exert excellent cleansing power without physically rubbing the skin, and is therefore suitable for use on a face sensitive to irritation.
After washing, the liquid composition for skin washing may be rinsed with water. In the case of rinsing with water, the mechanical force of the water stream is also used to perform the rinsing so as not to apply physical friction caused by the hand. The water used for rinsing can be contained in a spray type container, an injection or drip type container (particularly, a cleaning bottle), and is preferably contained in an injection or drip type container (particularly, a cleaning bottle), and is applied to the site to be cleaned in the same manner as the liquid composition for skin cleaning.
In addition, since the liquid composition for skin cleansing of the present invention can make the surfactant concentration extremely low, in this case, rinsing after cleansing may not be performed. Therefore, the liquid composition for skin cleansing of the present invention is also suitable for wiping purposes in hospitals, skin cleansing operation purposes such as face washing in beauty salons and beauty salons, disaster products, and the like. When the washing is not performed, the liquid composition for skin cleansing remaining in the washing area may be sucked and removed without rubbing by using a water-absorbent base such as a towel or a paper towel.
Manufacturing method
The liquid composition for skin cleansing of the present invention is produced by mixing the above-mentioned component (a) and component (B), and other components and the like which are blended as necessary, and preparing into a predetermined form.
2. Skin cleansing method
As described above, the amphiphilic ester can improve the cleansing power without applying physical friction to the skin in the skin cleanser composition comprising the surfactant derived from natural sources. Accordingly, the present invention also provides a method of skin cleansing comprising: a liquid composition for skin cleansing which contains a naturally-derived surfactant as component (A) and an amphiphilic ester as component (B) is applied to the skin without physically rubbing the skin. The skin cleansing method of the present invention can be carried out as a cleansing operation performed in a beauty salon or a beauty shop.
In the skin cleansing method, the type and amount of the components used, the form of the skin cleanser composition, and the like are as described in the section "1. liquid composition for skin cleansing" above.
Examples
The present invention will be described in more detail with reference to the following examples, but the present invention is not limited to these examples.
Test examples
Liquid compositions for skin cleansing having compositions shown in tables 1 to 4 were prepared. The details of each component shown in tables 1 to 4 are as follows. The liquid compositions for skin cleansing shown in tables 1 to 4 were liquid, and had viscosities at 20 ℃ (measured at 6rpm in spindle No3 of BL viscometer (B type viscometer manufactured by Brookfield corporation)) of 5000mPa · s or less.
Lysolecithin: lysolecithin KYOWA (リゾレシチン collaborating) (made by collaborating fermentation organisms)
Lecithin: BASIS LP-20 (Riqing Aoliyou made)
Hydrogenated lecithin: BASIS LP-20H (Riqing Ouliyou system)
Saponin: sapindus mukurossi extract powder (one pill prepared by natural beauty) (saponin content 20 wt%)
Sodium surfactin: KANEKA Surfactin (manufactured by KANEKA)
Bis-diethoxydiol cyclohexane 1,4-dicarboxylate ("Neosolve-Aqulio (trade name)" made by Nippon Kogyo Co., Ltd.)
Bisethoxydiglycol succinate ("HAIAQUEOSTER DCS (trade name)" manufactured by higher alcohol industries Co., Ltd.)
< evaluation of detergency >
For the prepared liquid composition for skin cleansing, 10 cosmetic evaluation panelists performed detergency evaluation. Specifically, each of the liquid compositions for skin cleansing was stored in a pump spray container ("Z-155-C110 (trade name)" manufactured by bamboo container co., ltd., and the spray amount per 1 press was 0.15g), and applied by directly spraying 1.5g to the face. Left for about 5 seconds, and thereafter, rinsed with water without touching the face with hands. After the face was pressed with a towel and water was sucked, the skin was evaluated for sensory evaluation of the sensation of dirt falling based on the following indices, and the evaluation was performed.
And 5, dividing: sufficient feeling of soil falling
And 4, dividing: feeling of soil falling
And 3, dividing: it cannot be said whether or not the soil is sensed to fall off
And 2, dividing: hardly any peeling of the soil was sensed
1 minute: no dirt was sensed to fall off
The scores of 10 panelists were summed up, and the degree of detergency was evaluated according to the following classification. The results are shown in tables 1 to 4.
Very good: over 45 minutes
O: 40 minutes or more and less than 45 minutes
And (delta): 35 minutes or more and less than 40 minutes
X: less than 35 minutes
< evaluation of tightening feeling >
For the prepared liquid composition for skin cleansing, 10 cosmetic evaluation panelists performed the tightness evaluation. Specifically, each of the liquid compositions for skin cleansing was stored in a pump spray container ("Z-155-C110 (trade name)" manufactured by bamboo container co., ltd., and the spray amount per 1 press was 0.15g), and applied by directly spraying 1.5g to the face. Left for about 5 seconds, and thereafter, rinsed with water without touching the face with hands. After the face was pressed with a towel and water was absorbed, the tightness was evaluated organoleptically based on the following criteria, and thereby the score was obtained. The stronger the tightness, the less sufficient the moisture retention.
And 5, dividing: completely does not feel tight
And 4, dividing: hardly felt a tight feeling
And 3, dividing: feeling only slight tightness
And 2, dividing: feeling of tightness
1 minute: strongly feel the sense of tightness
The scores of 10 panelists were summed up, and the degree of tightness was evaluated according to the following classification. The results are shown in tables 3 to 4.
Very good: over 45 minutes
O: 40 minutes or more and less than 45 minutes
And (delta): 35 minutes or more and less than 40 minutes
X: less than 35 minutes
< test for stimulating skin by cultured epidermis (in vitro evaluation of skin irritation) >
The cultured epidermal skin irritation test was performed on the prepared liquid composition for skin cleansing as follows.
1. Preparation of culture epidermal MODEL LabCyte EPI-MODEL24
The test medium was heated and 0.5mL of each was added to a 24-well test plate. The culture epidermis MODEL LabCyte EPI-MODEL24 (batch No.: LCE24-180226-A) was transferred to a 24-well test plate supplemented with test medium. After confirming that no air bubbles are present on the bottom surface of the culture cup, adding CO2The incubator is allowed to stand for more than 1 hour until exposed to the test substance.
2. Application and cleaning of test objects
12 of 24 epidermal models were used (the remainder was kept pre-cultured until the official test). Test plates from 24 wells were removed from CO2Taking out the culture box. The test medium was heated and 1.0mL of each was added to row 3 of the 24-well assay plate. Without using a pump spray container, 25. mu.L of the test substance (each liquid composition for skin cleansing) was dropped onto the culture epidermis of the culture cup, and the entire area was exposed. After the exposure, the test substance was removed by aspiration at 1 minute, 5 minutes, and 10 minutes, and the culture epidermis model in the cup was washed with Phosphate Buffered Saline (PBS) and transferred to the 24-well test plate, line 3.
MTT assay
The MTT assay is the following: formazan pigment produced by reduction of MTT [3- (4, 5-dimethylthiazol-2-yl) -2, 5-diphenyltetrazolium bromide ] taken into cells by a mitochondrial dehydrogenase located in the cells was extracted with an organic solvent, and the absorbance at 570nm was measured, thereby measuring the viable cell rate.
10mL of MTT medium was prepared at a final concentration of 0.5 mg/mL. MTT medium was heated and 0.5mL of each was added to row 4 of the 24-well assay plate. Transfer the cultured epidermis model to 24-well assay plate, line 4, and place CO2In the incubator, MTT reaction was performed for 3 hours. After the MTT reaction was completed, the cultured skin was grasped with forceps and removed, and transferred to a 1.5mL microtube. The culture epidermis model was completely immersed in 300. mu.L of isopropyl alcohol in a microtube. After that, the mixture was allowed to stand for 2 hours, and a vortex was applied to the microtube to extract the pigment. The extract (200mL) was placed in each well of a 96-well plate. In addition, as a blank (negative control), 200. mu.L of isopropanol was added to A1. The absorbance at 570nm and 650nm was measured with a microplate reader. The living cell rate of the specimen was calculated from the following formula, using the value obtained by subtracting the absorbance at 570nm from the absorbance at 650nm as the measured value.
[ mathematical formula 1 ]
The living cell rate was classified based on the following criteria, and skin irritation was evaluated. The results are shown in tables 3 to 4.
Very good: over 90 percent
O: more than 75 percent and less than 90 percent
And (delta): more than 65% and less than 75%
X: more than 50 percent and less than 65 percent
X: less than 50 percent
As shown in tables 1 to 4, the skin cleansing liquid compositions (comparative examples 13 to 16) containing the surfactant at a concentration of more than 2% by weight exhibited skin irritation, and the skin cleansing liquid compositions (comparative examples 1 to 10) containing the surfactant derived from a natural source at a concentration of 0.025 to 2% by weight exhibited no cleansing power. On the other hand, the skin cleansing liquid compositions (examples 1 to 21) containing the amphiphilic esters (comparative examples 11 to 12) alone, which do not exhibit cleansing power, and 0.025 to 2 wt% of the naturally derived surfactant were applied directly to the skin by spraying from a spray container alone, and thus excellent cleansing power was obtained by only the mechanical force of a liquid stream without applying any physical friction. That is, it was shown that the skin can be gently washed. Further, as shown in examples 4 to 7, 9, 11, 15, and 17 to 21, the liquid composition for skin cleansing of the present invention shows an improvement in cleansing power while suppressing skin irritation and a tight feeling due to insufficient moisturizing. That is, it is shown that by setting the concentration of the surfactant derived from natural sources in the liquid composition for skin cleansing which is directly applied to the skin by spraying to 0.025 to 2% by weight, it is possible to achieve gentle cleansing of the skin both physically and chemically.
[ TABLE 1 ]
[ TABLE 2 ]
[ TABLE 3 ]
[ TABLE 4 ]
In the table, the unit of the numerical value indicating the blending amount of each component is% by weight. In addition, the numerical values in parentheses represent the converted amounts of the components.
Claims (7)
1. A liquid composition for skin cleansing comprising (A) a surfactant derived from a natural source and (B) an amphiphilic ester,
the content of the (A) is 0.025-2 wt%,
the liquid composition for skin cleansing is used for cleansing without applying physical friction to the skin.
2. The liquid composition for skin cleansing according to claim 1, wherein the component (B) is selected from the group consisting of bis (polyoxyalkylene alkyl ether) dicarboxylate, dialkoxyalkyl dicarboxylate and polyglyceryl-10 eicosadipates/tetradecadipates.
3. The liquid composition for skin cleansing according to claim 2, wherein the dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester is bis-diethoxydiblycolcyclohexane 1, 4-dicarboxylate.
4. The liquid composition for skin cleansing according to any one of claims 1 to 3, wherein the component (A) is selected from the group consisting of glycerophospholipids, saponins and lipopeptides.
5. The liquid composition for skin cleansing according to claim 4, wherein the glycerophospholipid is selected from the group consisting of lecithin, lysolecithin and hydrogenated lecithin.
6. The liquid composition for skin cleansing according to claim 4, wherein the lipopeptide is selected from the group consisting of surfactin and salts thereof.
7. A method of skin cleansing, comprising:
a liquid composition for skin cleansing, which contains (A) a surfactant derived from a natural source and (B) an amphiphilic ester, wherein the content of (A) is 0.025-2 wt%, is applied to the skin without applying physical friction to the skin.
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| JP2019-118266 | 2019-06-26 | ||
| JP2019118266A JP7344020B2 (en) | 2019-06-26 | 2019-06-26 | Liquid composition for skin cleansing |
| PCT/JP2020/023786 WO2020262158A1 (en) | 2019-06-26 | 2020-06-17 | Liquid composition for cleaning skin |
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| CN112449597A true CN112449597A (en) | 2021-03-05 |
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| JP (1) | JP7344020B2 (en) |
| CN (1) | CN112449597A (en) |
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| CN113083151A (en) * | 2021-03-16 | 2021-07-09 | 华东理工大学 | Synergistic thickening viscoelastic micelle system of sodium surfactin and chlorinated cationic surfactant |
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| JP2015199684A (en) * | 2014-04-08 | 2015-11-12 | ホーユー株式会社 | Detergent composition and method for inhibiting skin irritation using the same |
| JP2016044180A (en) * | 2014-08-20 | 2016-04-04 | ホシケミカルズ株式会社 | Cosmetic |
| JP2018024639A (en) * | 2016-07-27 | 2018-02-15 | 日本精化株式会社 | Cosmetic composition comprising mannosylerythritol lipid |
| JP2019059679A (en) * | 2017-09-25 | 2019-04-18 | 株式会社コーセー | Aqueous cleansing cosmetic |
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| JP6262414B2 (en) * | 2011-04-22 | 2018-01-17 | ロート製薬株式会社 | Antibacterial composition |
| JP5946422B2 (en) * | 2013-03-19 | 2016-07-06 | 株式会社マンダム | Aqueous cleansing cosmetics |
| JP7471780B2 (en) * | 2018-06-27 | 2024-04-22 | 小林製薬株式会社 | Skin cleansing spray |
| JP7360826B2 (en) * | 2018-06-27 | 2023-10-13 | 小林製薬株式会社 | Liquid composition for skin cleansing |
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2019
- 2019-06-26 JP JP2019118266A patent/JP7344020B2/en active Active
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102892399A (en) * | 2010-03-12 | 2013-01-23 | 日清奥利友集团株式会社 | Composition for external use on skin, cosmetic, and cleaning agent |
| JP2015199684A (en) * | 2014-04-08 | 2015-11-12 | ホーユー株式会社 | Detergent composition and method for inhibiting skin irritation using the same |
| JP2016044180A (en) * | 2014-08-20 | 2016-04-04 | ホシケミカルズ株式会社 | Cosmetic |
| JP2018024639A (en) * | 2016-07-27 | 2018-02-15 | 日本精化株式会社 | Cosmetic composition comprising mannosylerythritol lipid |
| JP2019059679A (en) * | 2017-09-25 | 2019-04-18 | 株式会社コーセー | Aqueous cleansing cosmetic |
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| CN113083151A (en) * | 2021-03-16 | 2021-07-09 | 华东理工大学 | Synergistic thickening viscoelastic micelle system of sodium surfactin and chlorinated cationic surfactant |
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| WO2020262158A1 (en) | 2020-12-30 |
| JP7344020B2 (en) | 2023-09-13 |
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