CN112370520A

CN112370520A - Traditional Chinese medicine composition for treating psoriasis and application thereof

Info

Publication number: CN112370520A
Application number: CN202011444445.0A
Authority: CN
Inventors: 李斌; 李欣; 罗楹; 蒯仂; 范斌; 孙晓颖; 周蜜; 李洪锦; 茹意
Original assignee: Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of TCM
Current assignee: Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of TCM
Priority date: 2020-12-11
Filing date: 2020-12-11
Publication date: 2021-02-19

Abstract

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating psoriasis and application thereof, wherein the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 3-15 parts of astragalus membranaceus, 2-10 parts of honey-fried licorice root, 3-15 parts of angelica sinensis, 2-10 parts of ligusticum wallichii, 2-10 parts of peach kernels, 7-30 parts of salvia miltiorrhiza, 7-30 parts of curcuma zedoary, 3-15 parts of medicinal cyathula root and 7-30 parts of smilax china. The invention also comprises the application of the traditional Chinese medicine composition in preparing a medicine for treating psoriasis. Its advantages are: the traditional Chinese medicine composition is prepared by optimizing the raw material medicines and the weight part ratio among the raw material medicines, has the effects of activating blood and promoting qi circulation, removing blood stasis and relieving pain, is prepared by taking the root of red-rooted salvia and the peach kernel as monarch medicines, and combining the monarch medicines and the monarch medicines, activating blood and removing blood stasis, cooling blood and removing carbuncle, and is prepared by taking the root of zedoary, the rhizome of chuanxiong and the astragalus root as ministerial medicines, and taking the chinaroot greenbrier rhizome, the Chinese angelica and the radix cyathulae as adjuvant medicines, and taking the raw liquorice as adjuvant medicines to harmonize.

Description

Traditional Chinese medicine composition for treating psoriasis and application thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating psoriasis and application thereof.

Background

Psoriasis is a common chronic, recurrent inflammatory skin disease. The basic skin lesions are erythema, papules, or patches covered with multiple silvery-white scales. The occurrence parts are usually found on the body surface and head, and are usually multiple layers of silvery white dry scales on erythema. The cause of psoriasis is not completely clear and intractable, and is classified as one of ten intractable diseases by the world health organization. The pathogenesis of psoriasis is related to functions of infection factors, endocrine dysfunction, immune dysfunction, mental factors and the like. The initial symptoms of psoriasis begin to be red spot rash with large millet grains to large soybeans, the spot rash gradually expands and increases along with the development of the disease condition, even the spot rash is fused into tablets, the bottom is obviously infiltrated, the edge is clear, the periphery has inflammation and is in the shapes of drops, coins, maps, discs, oyster shells and the like. The disease has high incidence rate, especially in young and strong years, the disease is better in winter and spring, part of people have family genetic history, the disease is frequently and repeatedly attacked, and the disease is difficult to be itchy during attack, so that the appearance is influenced. At present, topical medicines such as cutin promoting agents, corticoid alcohol cream and the like are mostly adopted for treating psoriasis; the drugs used systemically include immunosuppressants, tretinoin, antibiotics, cortisol, and the like. The medicines have good recent treatment effect on psoriasis, but have large side effect and high recurrence rate after long-term use. The Korte study showed that: the adverse effects of psoriasis on quality of life can lead to significant chronic stress which in turn exacerbates psoriasis, a disease-related stress factor that manifests to varying degrees in each patient. Moreover, due to the inherent characteristics of psoriasis, many patients suffer from skin appearance, drug side effects, economic burden, psychological stress, etc. for a long time, and the quality of life is seriously affected, which is not overlooked by dermatologists in clinical treatment and research.

Aiming at the defects of the prior art, the invention provides a traditional Chinese medicine composition TDG for treating psoriasis, and experimental results show that the traditional Chinese medicine composition TDG has the effects of promoting blood circulation and activating qi, removing blood stasis and relieving pain, and has good curative effect. The traditional Chinese medicine composition for treating psoriasis and the application thereof are not reported at present.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine composition for treating psoriasis and application thereof aiming at the defects of the prior art.

In order to achieve the purpose, the invention adopts the technical scheme that:

in a first aspect, the invention provides a traditional Chinese medicine composition for treating psoriasis, which comprises the following raw material medicines in parts by weight: 3-15 parts of astragalus membranaceus, 2-10 parts of honey-fried licorice root, 3-15 parts of angelica sinensis, 2-10 parts of ligusticum wallichii, 2-10 parts of peach kernels, 7-30 parts of salvia miltiorrhiza, 7-30 parts of curcuma zedoary, 3-15 parts of medicinal cyathula root and 7-30 parts of smilax china.

Preferably, the traditional Chinese medicine composition consists of the following raw material medicines in parts by weight: 5-15 parts of astragalus membranaceus, 5-10 parts of honey-fried licorice root, 5-15 parts of angelica sinensis, 5-10 parts of ligusticum wallichii, 5-10 parts of peach kernels, 15-30 parts of salvia miltiorrhiza, 15-30 parts of curcuma zedoary, 5-15 parts of medicinal cyathula root and 15-30 parts of smilax china.

Preferably, the traditional Chinese medicine composition consists of the following raw material medicines in parts by weight: 15 parts of astragalus, 10 parts of honey-fried licorice root, 15 parts of angelica, 10 parts of ligusticum wallichii, 10 parts of peach kernel, 30 parts of salvia miltiorrhiza, 30 parts of curcuma zedoary, 15 parts of medicinal cyathula root and 30 parts of chinaroot greenbrier.

Further, the traditional Chinese medicine composition is prepared into a clinically acceptable pharmaceutical preparation according to a conventional traditional Chinese medicine preparation method.

Preferably, the pharmaceutical preparation is granules, powder, capsules, tablets, mixture or oral liquid.

In a second aspect, the invention provides an application of the traditional Chinese medicine composition in preparing a medicine for treating psoriasis.

In a third aspect, the invention provides a medicament for treating psoriasis, which is prepared by decocting the Chinese medicinal composition in water.

Preferably, the preparation method of the medicament comprises the following steps:

(1) taking the raw materials according to the proportion, adding water for decocting, boiling with soft fire for 1 hour; filtering to obtain filtrate I and residue respectively, and bottling the filtrate I for use;

(2) decocting the obtained medicinal residues in water, boiling with slow fire for 1 hr, filtering to obtain filtrate II, and bottling;

(3) and combining the first filtrate and the second filtrate, and heating and concentrating for later use.

Square solution:

the whole prescription takes the salvia miltiorrhiza and the peach kernel as monarch drugs, the salvia miltiorrhiza is bitter and slightly cold in property, enters heart and liver channels, cools and activates blood circulation, has the functions of removing blood stasis, clearing heat and eliminating carbuncle and swelling, and is a key drug for activating blood circulation and removing blood stasis, the peach kernel is bitter in taste and enters heart and liver blood system, and is good for purging blood stagnation, and the peach kernel are combined to activate blood circulation and remove blood stasis, cool blood and eliminate carbuncle. The rhizoma zedoariae has the functions of removing blood stasis, relieving swelling and alleviating pain, helps monarch drugs to remove blood stasis and eliminate mass, has the effects of dispersing pungent taste, relieving diarrhea and dredging warmth, can break blood and remove stasis, can promote qi circulation and relieve pain, is pungent and warm in flavor, is a blood-qi-activating drug, leads qi to circulate blood, strengthens middle-jiao and tonifies qi, promotes blood circulation and generates blood, is reinforced by the rhizoma zedoariae and the rhizoma ligustici wallichii, leads blood stasis to be eliminated when qi and blood circulate, and is a ministeri. Smilax china root, rhizoma Smilacis chinensis, radix Angelicae sinensis, radix Cyathulae, radix Angelicae sinensis, radix rehmanniae, radix Cyathulae, radix. Raw gan Cao harmonizes properties of herbs and has the action of clearing heat and removing toxicity, and this recipe is very drastic, so gan Cao can slightly harmonize stomach and protect middle energizer, so it is used as an adjuvant drug. The medicines are combined to play the roles of activating blood and promoting qi circulation, and removing blood stasis and relieving pain.

The invention has the advantages that:

the inventor selects the raw materials and the weight parts of the raw materials according to years of clinical experience, aims at the pathogenesis of psoriasis, treats the psoriasis according to syndrome differentiation, and the traditional Chinese medicine of the formula accords with the compatibility and treatment rule of 'monarch, minister, assistant and guide', and has the effects of promoting blood circulation, promoting qi circulation, removing blood stasis and relieving pain. The experimental result shows that the composition has optimal curative effect and good curative effect in parts by weight, solves the pain of patients of the type, has low cost and can be well applied to clinic.

Drawings

Figure 1 is the appearance of back lesions and psoriasis PASI score (n-4) for various groups of mice with different doses of peach-Dan formulation intervention. A. Back skin damage appearance on day 12 of each group of mice experiment; B. the dorsal skin lesion psoriasis PASI scores (erythema, scaling, infiltration and total score) were obtained for the groups of mice. Compared with the control group, the method has the advantages that,^#p<0.05，^##p<0.01，^###p<0.001; in contrast to the IMQ set,^*p<0.05，^**p<0.01，^***p<0.001。

figure 2 is a graph of the appearance of ear lesions, psoriasis PASI scores and ear thickness change (n-4) for various groups of mice with different doses of the peach formulation intervention. A. Ear skin lesion appearance on day 12 of each group of mice experiment; B. the dorsal skin lesion psoriasis PASI scores (erythema, scaling) and ear thickness changes were measured in the mice of each group. Compared with the control group, the method has the advantages that,^#p<0.05，^##p<0.01，^###p<0.001; in contrast to the IMQ set,^*p<0.05，^**p<0.01，^***p<0.001。

figure 3 is a graph of the high dose tonka formulation interfering with histopathological changes in the mouse back and epidermal keratinocyte proliferation (x 200, n-4). Compared with the control group, the method has the advantages that,^#p<0.05，^##p<0.01，^###p<0.001; in contrast to the IMQ set,^*p<0.05，^**p<0.01，^***p<0.001。

figure 4 is a graph of the high dose of gadomen interfering with mouse ear histopathological changes and epidermal keratinocyte proliferation (x 200, n-4). Compared with the control group, the method has the advantages that,^#p<0.05，^##p<0.01，^###p<0.001; in contrast to the IMQ set,^*p<0.05，^**p<0.01，^***p<0.001。

Detailed Description

The invention will be further illustrated with reference to specific embodiments. It should be understood that these examples are for illustrative purposes only and are not intended to limit the scope of the present invention. Furthermore, it should be understood that various changes and modifications can be made by those skilled in the art after reading the disclosure of the present invention, and equivalents fall within the scope of the appended claims.

EXAMPLE 1 Chinese medicinal composition 1

3 parts of astragalus, 2 parts of honey-fried licorice root, 3 parts of angelica, 2 parts of ligusticum wallichii, 2 parts of peach kernel, 7 parts of salvia miltiorrhiza, 7 parts of curcuma zedoary, 3 parts of medicinal cyathula root and 7 parts of chinaroot greenbrier.

EXAMPLE 2 Chinese medicinal composition (II)

15 parts of astragalus, 10 parts of honey-fried licorice root, 15 parts of angelica, 10 parts of ligusticum wallichii, 10 parts of peach kernel, 30 parts of salvia miltiorrhiza, 30 parts of curcuma zedoary, 15 parts of medicinal cyathula root and 30 parts of chinaroot greenbrier.

EXAMPLE 3 Chinese medicinal composition (III)

3 parts of astragalus, 10 parts of honey-fried licorice root, 3 parts of angelica, 10 parts of ligusticum wallichii, 2 parts of peach kernel, 30 parts of salvia miltiorrhiza, 7 parts of curcuma zedoary, 15 parts of medicinal cyathula root and 7 parts of chinaroot greenbrier.

EXAMPLE 4 Chinese medicinal composition (IV)

15 parts of astragalus, 2 parts of honey-fried licorice root, 15 parts of angelica, 2 parts of ligusticum wallichii, 10 parts of peach kernel, 7 parts of salvia miltiorrhiza, 30 parts of curcuma zedoary, 3 parts of medicinal cyathula root and 30 parts of chinaroot greenbrier.

EXAMPLE 5 Chinese medicinal composition (V)

5 parts of astragalus, 5 parts of honey-fried licorice root, 5 parts of angelica, 5 parts of ligusticum wallichii, 5 parts of peach kernel, 15 parts of salvia miltiorrhiza, 15 parts of curcuma zedoary, 5 parts of medicinal cyathula root and 15 parts of chinaroot greenbrier.

EXAMPLE 6 Chinese medicinal composition (VI)

EXAMPLE 7 Chinese medicinal composition (seven)

5 parts of astragalus, 10 parts of honey-fried licorice root, 5 parts of angelica, 10 parts of ligusticum wallichii, 5 parts of peach kernel, 30 parts of salvia miltiorrhiza, 15 parts of curcuma zedoary, 15 parts of medicinal cyathula root and 15 parts of chinaroot greenbrier.

EXAMPLE 8 Chinese medicinal composition (eight)

15 parts of astragalus, 5 parts of honey-fried licorice root, 15 parts of angelica, 5 parts of ligusticum wallichii, 10 parts of peach kernel, 15 parts of salvia miltiorrhiza, 30 parts of curcuma zedoary, 5 parts of medicinal cyathula root and 30 parts of chinaroot greenbrier.

EXAMPLE 9 Chinese medicinal composition (nine)

Example 10 decoction

The preparation method comprises the following steps:

(1) the raw materials are respectively taken according to the mixture ratio of the embodiments 1 to 9, decocted by adding water, boiled and boiled with soft fire for 1 hour; filtering to obtain filtrate I and residue respectively, and bottling the filtrate I for use;

(3) and combining the first filtrate and the second filtrate for later use.

EXAMPLE 11 granules

The preparation method comprises the following steps:

(1) the raw materials are respectively taken according to the mixture ratio of the embodiments 1 to 9, decocted by adding water, boiled and boiled with soft fire for 1 hour; filtering to obtain filtrate I and residue respectively, precipitating filtrate I, collecting supernatant, and bottling;

(2) decocting the obtained medicinal residues in water, boiling with slow fire for 1 hr, filtering to obtain filtrate II, precipitating filtrate II, collecting supernatant, and bottling;

(3) mixing the above supernatants, heating, concentrating to obtain fluid extract, and making into granule.

EXAMPLE 12 tablet/Capsule

The preparation method comprises the following steps:

(3) mixing the above supernatants, heating, concentrating to obtain soft extract, adding pharmaceutical adjuvants, vacuum drying, pulverizing, granulating, and making into tablet or capsule.

Example 13 acute toxicity test

1 animals

SPF grade ICR mice, female, weighing 20.0-23.0g, total 12, were purchased from Shanghai Si Laike laboratory animals, Inc.

2 medicine

The composition of the invention: prepared according to the method of example 6.

3 grouping

Animals were randomly divided into 2 groups of 6 animals each, test and control groups, after 1 day of adaptive feeding in an SPF-scale feeding room.

4 method of administration

The test group is administered with the composition of the invention for intragastric administration, and 3g of crude drugs/(kg. d) are combined; the control group was subjected to gavage with physiological saline. The administration was continued for 15 days.

5 Observation method

From day 1 of the start of the experiment, 1 observation of the animals, each day, morning and afternoon, recorded signs of appearance, behavioral activity, glandular secretion, respiration, excretions, symptoms of abnormal animal response, onset time, severity, duration and death. After the experiment, the mice were sacrificed and the heart, lung, kidney, liver, spleen, gastrointestinal tract and other internal organs were dissected and observed.

6 results

After the observation period is finished, the mice of the test group and the control group do not die, abnormal reaction does not occur, the activity status and the mental status are good, and the excrement and the urine are normal. After the experiment is finished, the appearance of viscera, heart, lung, kidney, liver, spleen and gastrointestinal tract of the mouse are normal through anatomical observation, and edema or bleeding is not seen. The composition of the invention has no obvious toxic and side effect.

Example 14 animal experiments

1 animals

BALB/c mice, male, 7-9 weeks old, 25g + -3 g

2 preparation of the drug

Peach blossom prescription (high dose): 15g of astragalus, 10g of honey-fried licorice root, 15g of angelica, 10g of ligusticum wallichii, 10g of peach kernel, 30g of salvia miltiorrhiza, 30g of curcuma zedoary, 15g of medicinal cyathula root and 30g of smilax china. 1650ml water, boiling with slow fire for 1 hr, and filtering with double layer gauze. The above operation is repeated once. Mixing the two filtrates, heating and concentrating until the concentration reaches 1g crude drug/ml for use.

Peach prescription (medium dose): peach red prescription (high dose) is diluted 2 times in equal proportion.

Peach blossom prescription (low dose): the peach red prescription (middle dose) is diluted by 2 times in equal proportion.

3 grouping of formulations

Blank control group (control group), model group (IMQ group), Suodanfo high dose group (optimum ratio preparation, IMQ + TDG (H) group), Suodanfo medium dose group (IMQ + TDG (M) group, Suodanfo low dose group (IMQ + TDG (L)) group)

4 Experimental methods

After the hair on the back of the mouse is shaved off (2X 2 cm)²) Randomly divided into 5 groups:

control group: the ear and back skin was smeared with 62.5mg of petrolatum.

IMQ group, 62.5mg of 5% Imiquimod (IMQ) cream was applied to the ear and back skin for 6 hours, followed by gavage of 0.9% NaCl solution (1.8 g/kg).

IMQ + TDG (H) group: after applying 62.5mg of 5% IMQ cream to the ear and back for 6 hours, a high dose Suo Dan Fang (TDG) (1.8g/kg) was administered by gavage.

IMQ + TDG (M) group: after applying 62.5mg of 5% IMQ cream to the ear and back for 6 hours, the medium dose Suodan formulation (1.8g/kg) was administered intragastrically.

IMQ + TDG (L) group: after applying 62.5mg of 5% IMQ cream to the ear and back for 6 hours, the low dose Suodan formulation (1.8g/kg) was gavaged.

All treatments started 1 time per day for 12 consecutive days from the day of IMQ application (day 0). The psoriasis skin lesion area and severity score (PASI score) consisted of skin erythema, infiltration, and scaling, and was used to score the severity of skin inflammation on the back and ears of mice. Each parameter of the score is between 0-4. 0. No clinical sign, mild clinical sign, moderate clinical sign, severe clinical sign and severe clinical sign are respectively assigned to 1, 2, 3 and 4. Specimen samplingFasting and drinking water for 12 hours before collection, and inhaling CO on day 12₂And (5) euthanizing. Skin lesion tissues of the back and ear were collected for further experiments.

5 results of the experiment

1) The peach pill formula can effectively improve psoriasis-like dermatitis of mice induced by imiquimod, and the effect of a high-dose group is optimal

On day 12 of IMQ modeling, IMQ groups showed typical psoriasis-like skin lesions on the back and ear skin (fig. 1A, fig. 2A), a marked increase in psoriasis PASI scores (scales, erythema, infiltration and gross scores) and ear thickness (fig. 1B, fig. 2B) compared to control groups. After the mice are treated by high-dose, medium-dose and low-dose TDG for 12 days, the skin damage symptoms of the psoriasis-like mice induced by IMQ are obviously reduced (figure 1A and figure 2A), the psoriasis PASI scores (scales, erythema, infiltration and total score) and the ear thickness are reduced (figure 1B and figure 2B), wherein the reduction degree of the psoriasis-like symptoms of the mice interfered by the high-dose TDG is the most obvious.

2) The high-dose peach pill formula can obviously reduce mouse skin damage keratinocyte proliferation induced by imiquimod

On day 12 of intervention with the high dose peach prescription, histopathological changes of skin lesions on the backs and ears of the mice can be observed: the skin of the control group mice is represented by regularly arranged epidermis layers and acanthosis, the true epidermis boundary is clear, and inflammatory infiltration and capillary vessel dilation congestion of lymphocytes are avoided; the IMQ group has psoriasis-like pathological changes such as obvious epidermal parakeratosis and hyperkeratosis, epidermal pestle hyperplasia, dermal papilla extending, dermal papilla capillary dilatation and congestion, inflammatory cell infiltration around the upper dermal blood vessels and the like. After the peach tree trunk is applied, the psoriasis-like pathological manifestations are obviously improved (figure 3 and figure 4).

On the 12 th day of intervention of the high-dose peach prescription, the immunohistochemical result shows that compared with the control group, the epidermal keratinocytes are abnormally proliferated in the skin lesions of the back and the ear of mice in the IMQ group, and a large amount of Ki67 and PCNA nuclear positive cells can be seen; compared with the IMQ group, the mice in the IMQ + TDG (H) group have obviously reduced epidermal keratinocyte proliferation (figure 3, figure 4).

Example 15 clinical trial

1 data of

1.1 clinical data

261 patients of hospital visits in 7-2020-8 are selected, and divided into four groups by adopting a random number table method, wherein the four groups are respectively an experimental group, a comparative group and a control group. Before treatment, patients in each group have no significant difference in sex, age, disease course and the like, and have good balance among groups and comparability.

1.2 diagnostic criteria

(1) Psoriasis with drops

The basis of diagnosis is as follows: 1. the rash is 0.3-0.5cm papule and maculopapule, and the color is flush, covered with scale and widely distributed; 2. before eruption, the patient often has a history of streptococcus infection of throat; 3. white blood cell count, increased neutrophil ratio, increased anti-O; 4. with appropriate treatment, the rash subsides within weeks, with a few transitions to a chronic course.

(2) Plaque psoriasis

The basis of diagnosis is as follows: 1. the rash is basically characterized by a dark red plaque or an infiltrative erythema with clear borders and white and silvery-white scales on the surface; 2. the physical examination shows the phenomenon of wax drop, the phenomenon of thin film, the phenomenon of punctate bleeding (Auspitz characteristic), the phenomenon of fasciculate hair and the like; 3. the rash is better on the scalp, back and extremities. 4. With or without itching; 5. the progressive phase may have a "homomorphic reaction" (Kobner phenomenon); 6. the skin lesions are recurrent, and most of them are severe in winter and mild in summer.

1.3 inclusion criteria

Clinically, the traditional Chinese medicine composition meets the diagnosis standard of psoriasis vulgaris (spot psoriasis/plaque psoriasis), routine examination is carried out except other organic lesions, glucocorticoid and immunosuppressant are not used within 1 month before admission, and retinoic acid is not used within 3 months.

1.4 rejection Standard

Patients with visceral diseases such as severe center of gravity, brain, liver, kidney, etc. are also included; pregnant women and lactating women are not in accordance with the regulations or are not matched with the detection and the periodic re-diagnosis to influence the judgment of curative effect and safety.

1.5 termination and withdrawal of clinical trial criteria: other diseases appear in the test, affecting the test performers; other situations are not foreseeable.

2 method

2.1 methods of treatment

Experimental groups: the traditional Chinese medicine composition with the mixture ratio of the embodiment 9 is prepared into granules.

Comparative example one set: taking the traditional Chinese medicine composition: 16 parts of astragalus, 11 parts of honey-fried licorice root, 2 parts of angelica, 12 parts of ligusticum wallichii, 13 parts of peach kernel, 5 parts of salvia miltiorrhiza, 31 parts of curcuma zedoary, 2 parts of medicinal cyathula root and 5 parts of chinaroot greenbrier rhizome, and the traditional Chinese medicine is prepared into granules.

Comparative examples two groups: taking the traditional Chinese medicine composition: 30 parts of salvia miltiorrhiza, 10 parts of peach kernel, 5 parts of honey-fried licorice root, 5 parts of red paeony root, 10 parts of safflower, 10 parts of raw cattail pollen, 10 parts of pseudo-ginseng, 15 parts of honeysuckle, 15 parts of weeping forsythia and 15 parts of dandelion, and preparing the granules.

Comparative three groups: taking the traditional Chinese medicine composition: 2 parts of astragalus, 1 part of honey-fried licorice root, 16 parts of angelica, 1 part of ligusticum wallichii, 1 part of peach kernel, 32 parts of salvia miltiorrhiza, 5 parts of curcuma zedoary, 16 parts of medicinal cyathula root and 31 parts of chinaroot greenbrier rhizome, and the granules are prepared.

Control group: 0.025% vitamin A acid soft cream is used at night twice a day.

Except for the control group, all the other groups of medicines are uniformly packaged by using uniform packaging labels in the experimental process.

Each group of patients was evaluated every 2 weeks for 8 weeks and the results were counted after 8 weeks. Relapse rates were observed at week 9-16 follow-up.

2.2 assessment of efficacy

2.2.1PASI score Standard

Psoriasis skin lesion area score criteria are given in the following table

2.2.2 psoriasis severity Scoring Standard

2.2.3PASI scoring method:

the method divides the human body into four parts: calculating skin damage areas of the head and neck, the trunk, the upper limbs and the lower limbs according to the table, calculating rash scales A, infiltration B and erythema C according to the table, adding the calculated skin damage areas, multiplying the calculated skin damage areas by respective coefficients, and finally adding scores of four parts (the head and neck, the trunk, the upper limbs and the lower limbs) of the whole body to obtain a PASI total score.

PASI total score is head area integral × head severity score (a + B + C) × 0.1+ upper limb area integral × upper limb severity score (a + B + C) × 0.2+ trunk area integral × trunk severity score (a + B + C) × 0.3+ lower limb area integral × lower limb severity score (a + B + C) × 0.4.

Follow-up recurrence: follow-up of clinically cured cases was performed by telephone consultation and hospital-visit.

2.2.4 evaluation index of therapeutic Effect

Therapeutic index (pre-treatment PASI value-post-treatment PASI value)/pre-treatment PASI value x 100%

The clinical cure is as follows: the curative effect index is more than or equal to 90 percent

The effect is shown: the curative effect index is more than or equal to 60 percent and less than 90 percent

The method has the following advantages: the curative effect index is more than or equal to 20 percent and less than 60 percent

And (4) invalidation: the curative effect index is less than 20 percent

Effective rate (number of cure cases + number of obvious cases + number of effective cases)/total number of cases × 100%.

3 results

3.1 comparison of therapeutic effects of groups

TABLE 1 comparison of therapeutic effects of the groups

3.2 follow-up recurrence rates for each group

TABLE 2 follow-up recurrence rates for each group

Group of	Example number (n)	Recurrence of disease	Recurrence Rate (%)
				Experimental group	52	7	13.5％
Comparative example group	53	12	22.6％
				Comparative examples two groups	52	14	26.9％
Comparative example three groups	51	11	21.6％
				Control group	53	25	47.2％

3 conclusion

The experimental results show that the curative effect of the experimental group is obviously superior to that of other groups, the recurrence rate of the experimental group is obviously lower than that of other groups, the curative effect of the experimental group is optimal, and the formula proportion is optimal.

The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and additions can be made without departing from the principle of the present invention, and these should also be considered as the protection scope of the present invention.

Claims

1. The traditional Chinese medicine composition for treating psoriasis is characterized by comprising the following raw material medicines in parts by weight: 3-15 parts of astragalus membranaceus, 2-10 parts of honey-fried licorice root, 3-15 parts of angelica sinensis, 2-10 parts of ligusticum wallichii, 2-10 parts of peach kernels, 7-30 parts of salvia miltiorrhiza, 7-30 parts of curcuma zedoary, 3-15 parts of medicinal cyathula root and 7-30 parts of smilax china.

2. The traditional Chinese medicine composition according to claim 1, which is prepared from the following raw materials in parts by weight: 5-15 parts of astragalus membranaceus, 5-10 parts of honey-fried licorice root, 5-15 parts of angelica sinensis, 5-10 parts of ligusticum wallichii, 5-10 parts of peach kernels, 15-30 parts of salvia miltiorrhiza, 15-30 parts of curcuma zedoary, 5-15 parts of medicinal cyathula root and 15-30 parts of smilax china.

3. The traditional Chinese medicine composition according to claim 1, which is prepared from the following raw materials in parts by weight: 15 parts of astragalus, 10 parts of honey-fried licorice root, 15 parts of angelica, 10 parts of ligusticum wallichii, 10 parts of peach kernel, 30 parts of salvia miltiorrhiza, 30 parts of curcuma zedoary, 15 parts of medicinal cyathula root and 30 parts of chinaroot greenbrier.

4. The Chinese medicinal composition according to any one of claims 1 to 3, which is prepared into a clinically acceptable medicinal preparation according to a conventional Chinese medicinal preparation method.

5. The traditional Chinese medicine composition of claim 4, wherein the pharmaceutical preparation is a granule, a powder, a capsule, a tablet, a mixture or an oral liquid.

6. Use of a Chinese medicinal composition according to any one of claims 1 to 3 in the manufacture of a medicament for the treatment of psoriasis.

7. A medicament for treating psoriasis, which is prepared by decocting the Chinese medicinal composition of claim 1 in water.

8. The medicament of claim 7, wherein the preparation method comprises: