CN112353846A - A nail polish remover and its preparation method - Google Patents
A nail polish remover and its preparation method Download PDFInfo
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- CN112353846A CN112353846A CN202011263030.3A CN202011263030A CN112353846A CN 112353846 A CN112353846 A CN 112353846A CN 202011263030 A CN202011263030 A CN 202011263030A CN 112353846 A CN112353846 A CN 112353846A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/42—Cucurbitaceae (Cucumber family)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention discloses a nail polish remover and a preparation method thereof, wherein the nail polish remover comprises the following raw materials in parts by weight: 20-30 parts of goldthread root extract, 15-20 parts of balsam pear extract, 12-20 parts of mint, 0.2-1 part of bendinalinium, 0.1-0.5 part of citric acid and 10-15 parts of cellulose. The mint extract can prevent cariogenic bacteria such as streptococcus mutans, lactobacillus and actinomycetes in the oral cavity of an individual, the effect is not good, in the process of processing the balsam pear extract, an organic solvent is not used, the product is safe and pollution-free, the environment is not polluted in the extraction process, the extraction method is simple and quick, the extraction cost is low, the nutrient components of the balsam pear extract are rich, the nutrient component concentration of the balsam pear extract is higher, the effect is more obvious, the purpose of reasonably utilizing raw materials is achieved, waste and environment are avoided, mint is a messenger drug, and can clear away heat and toxic materials, viruses can be inhibited, meanwhile, the cool and fragrant smell of the mint extract can be easily accepted by children, and the source of the formula medicinal materials is wide.
Description
Technical Field
The invention relates to the technical field of water for treating onychomycosis, in particular to water for treating onychomycosis and a preparation method thereof.
Background
Hand-foot-and-mouth disease is an infectious disease caused by enteroviruses, and the enteroviruses causing the hand-foot-and-mouth disease are more than 20 types, wherein the most common enteroviruses are coxsackievirus A16 type (Cox A16) and enterovirus 71 type (EV 71). It is usually seen in children under 5 years old, with symptoms of stomachache, anorexia, low fever, small herpes or ulcer in the mouth, most children will heal themselves for about one week, and few children will cause complications such as myocarditis, pulmonary edema, aseptic meningoencephalitis, etc. The disease of some serious children will develop quickly and lead to death. Currently, there is a lack of effective therapeutic drugs for the major symptomatic treatment.
The infection pathways of the disease include the digestive tract, respiratory tract and contact transmission. Thus, the introduction of hygiene is the best preventive method for the disease. At present, products for preventing hand-foot-and-mouth diseases, such as infant products of ice cream brand, are available on the market, and are sterilized by using electrolyzed oxidizing water; the huike skin cleaning hand-cleaning liquid is prepared with medical alcohol 62.50 wt%, triclosan 0.60 wt%, aloe extract 4.00 wt% and vitamin E0.20 wt% and through mixing, and has the demerits of being not easy to carry and inconvenient to use, and the chemical components in the product may cause toxic side effect.
Many children have bad habits of biting nails, parents and teachers often teach and supervise, children know that the children are not good habits, but can not restrain the problem of biting the nails, and therefore the bitter nail water and the manufacturing method thereof are designed to solve the problems.
Disclosure of Invention
The invention aims to solve the defects in the prior art and provides a water for treating onychomycosis and a preparation method thereof.
In order to achieve the purpose, the invention adopts the following technical scheme:
the water for treating onychomycosis comprises the following raw materials in parts by weight: 20-30 parts of goldthread root extract, 15-20 parts of balsam pear extract, 12-20 parts of mint, 0.2-1 part of bendinalinium, 0.1-0.5 part of citric acid and 10-15 parts of cellulose.
As a preferable technical scheme of the invention, the goldthread root extract is prepared by adding 10-20 parts by weight of goldthread root into 100-150 parts by weight of water, boiling for 0.2-1 hour, cooling to normal temperature, and filtering to obtain filtrate.
According to a preferable technical scheme, fresh bitter gourd is adopted as the bitter gourd extracting solution, the bitter gourd extracting solution is ground into bitter gourd powder after being dried, the bitter gourd powder is mixed with water, the mass ratio of the bitter gourd powder to the water is 1:4, the bitter gourd powder liquid is filtered, filtrate is subjected to ultrasonic treatment and then is heated to 75-100 ℃ for extraction for more than 2 hours, and the temperature is reduced to room temperature after the extraction is finished, and the bitter gourd extracting solution is obtained through centrifugation and filtration.
According to a preferable technical scheme of the invention, the mint is mint essential oil or contains menthol and derivatives thereof, the cellulose is microcrystalline cellulose, and the grain size of the microcrystalline cellulose is 15-35 μm.
A preparation method of water for treating onychomycosis comprises the following steps,
s1, mixing the goldthread root extract, the balsam pear extract, the mint, the bendinalinium and the cellulose according to the weight part ratio;
s2, adding water into the mixed mixture, adding 2-5 times of water, mixing, and soaking for 30-45 minutes to obtain a mixed solution;
s3, boiling the mixed solution obtained in the step II for 20-30 minutes, filtering the mixed solution, and collecting the obtained filtrate;
s4, cooling the filtrate, adding citric acid into the filtrate after cooling, stirring and heating, standing at 60-80 ℃ for 15-20 minutes, taking the supernatant, concentrating under reduced pressure, centrifuging, filtering, and collecting the filtrate to obtain the water of the scabrous doellingeria herb.
As a preferred technical scheme of the invention, in the fourth step, the concentrated acid condition is 40-80 ℃, 0.04-0.10 Mpa, and the concentrated acid is concentrated to 10-40% of the original volume.
As a preferred technical scheme of the invention, the water of the carapace-making powder in the step four is taken and evenly applied to the hands of the children 3 times a week.
According to the bitter carapace water and the preparation method thereof, the mint extract has cariogenic bacteria such as streptococcus mutans, lactobacillus and actinomycetes in the oral cavity of an individual, the effect is poor, no organic solvent is used in the processing process of the balsam pear extract, the product is safe and pollution-free, the extraction process does not pollute the environment, the extraction method is simple and rapid, the extraction cost is low, the nutritional ingredients of the balsam pear extract are richer, the concentration of the nutritional ingredients of the balsam pear extract is higher, the effect is more obvious, the purpose of reasonably utilizing raw materials is achieved, waste and environment are avoided, mint is a messenger drug, heat and toxic materials are removed, viruses can be inhibited, meanwhile, the cool and fragrant smell of the balsam pear extract is easily accepted by children, the source of the formula medicinal materials is wide, and the price is low, and the goldthread root of the present invention has the effects of clearing heat, drying dampness;
the external formula has the effects of clearing heat, removing toxicity, resisting bacteria and diminishing inflammation, the goldthread root and the bitter gourd are extremely bitter in taste, and after being soaked in nails, patients can taste the bitter after biting the nails, and can feed back the bitter for a plurality of times for a long time, so that children can form subconscious idea of refusing to act of biting the nails, and the bitter taste of the bitter gourd can help children who like to suck the fingers to abstain from the bad habit of sucking the fingers, so that the nail biting disease is radically treated.
Drawings
The invention is described in further detail below with reference to the following figures and embodiments:
FIG. 1 is a flow diagram of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments.
Example one
The invention provides a water for treating onychomycosis and a preparation method thereof
The feed comprises the following raw materials in parts by weight: 20 parts of goldthread root extract, 15 parts of balsam pear extract, 12 parts of mint, 0.2 part of benzalkonium chloride, 0.1 part of citric acid and 10 parts of cellulose.
S1, mixing the goldthread root extract, the balsam pear extract, the mint, the bendinalinium and the cellulose according to the weight part ratio;
s2, adding water into the mixed mixture, adding 2-5 times of water, mixing, and soaking for 30-45 minutes to obtain a mixed solution;
s3, boiling the mixed solution obtained in the step II for 20-30 minutes, filtering the mixed solution, and collecting the obtained filtrate;
s4, cooling the filtrate, adding citric acid into the filtrate after cooling, stirring and heating, standing at 60-80 ℃ for 15-20 minutes, taking the supernatant, concentrating under reduced pressure, centrifuging, filtering, and collecting the filtrate to obtain the water of the scabrous doellingeria herb.
In step two of this example, 3 times the amount of water was added and soaked for 30 minutes, boiled for 20 minutes in step three, and incubated for 15 minutes at a temperature of 60 ℃ in step four.
Example two
The invention provides a water for treating onychomycosis and a preparation method thereof
The feed comprises the following raw materials in parts by weight: 25 parts of goldthread root extract, 18 parts of balsam pear extract, 16 parts of mint, 0.5 part of benzalkonium chloride, 0.3 part of citric acid and 12 parts of cellulose.
S1, mixing the goldthread root extract, the balsam pear extract, the mint, the bendinalinium and the cellulose according to the weight part ratio;
s2, adding water into the mixed mixture, adding 2-5 times of water, mixing, and soaking for 30-45 minutes to obtain a mixed solution;
s3, boiling the mixed solution obtained in the step II for 20-30 minutes, filtering the mixed solution, and collecting the obtained filtrate;
s4, cooling the filtrate, adding citric acid into the filtrate after cooling, stirring and heating, standing at 60-80 ℃ for 15-20 minutes, taking the supernatant, concentrating under reduced pressure, centrifuging, filtering, and collecting the filtrate to obtain the water of the scabrous doellingeria herb.
In step two of this example, 4 times the amount of water was added and soaked for 38 minutes, in step three, boiled for 25 minutes, and in step four, incubated at 70 ℃ for 18 minutes.
EXAMPLE III
The invention provides a water for treating onychomycosis and a preparation method thereof
The feed comprises the following raw materials in parts by weight: 30 parts of goldthread root extract, 20 parts of balsam pear extract, 20 parts of mint, 1 part of benzalkonium chloride, 0.5 part of citric acid and 15 parts of cellulose.
S1, mixing the goldthread root extract, the balsam pear extract, the mint, the bendinalinium and the cellulose according to the weight part ratio;
s2, adding water into the mixed mixture, adding 2-5 times of water, mixing, and soaking for 30-45 minutes to obtain a mixed solution;
s3, boiling the mixed solution obtained in the step II for 20-30 minutes, filtering the mixed solution, and collecting the obtained filtrate;
s4, cooling the filtrate, adding citric acid into the filtrate after cooling, stirring and heating, standing at 60-80 ℃ for 15-20 minutes, taking the supernatant, concentrating under reduced pressure, centrifuging, filtering, and collecting the filtrate to obtain the water of the scabrous doellingeria herb.
In step two of this example, 5 times the amount of water was added and soaked for 45 minutes, boiled for 30 minutes in step three, and kept at 80 ℃ for 20 minutes in step four.
The method comprises the following steps of randomly selecting 60 children frequently biting the fingers, randomly dividing the children into 4 groups, namely, an example group and a control group, wherein the example group is respectively coated on the fingernails of the children by using the manicure water produced in the example of the invention three times a day, the control group is coated on the fingernails of the children by using a manicure water with relatively good sale quantity under the NLiex brand, the manicure water is coated on the fingernails of the children three times a day in the same manner as the example group, and after the fingernails are used for 2 months, observing test results, wherein the test results are as follows:
the external formula has the effects of clearing away heat and toxic materials, resisting bacteria and diminishing inflammation, the goldthread root and the balsam pear are extremely bitter in taste, and after being soaked in nails, patients can feel that the external formula can feed back for a plurality of times for a long time when biting the nails, so that children can form subconscious idea of refusing to act to bite the nails, the bitter taste can help the children who like to suck the fingers to abstain the bad habit of sucking the fingers, thereby radically treating the nail biting disease, meanwhile, other components in the external formula can inhibit bacteria and the like, protect the health of human bodies, help to prevent the hand-foot-and-mouth disease, have no toxic or side effect and low cost, have good development and application prospects, are just the preferred specific implementation mode of the invention, but the protection range of the invention is not limited by the above, and any person skilled in the technical field can equally replace or change according to the technical scheme and the invention concept of the invention, are intended to be covered by the scope of the present invention.
Claims (7)
1. The water for treating onychomycosis is characterized by comprising the following raw materials in parts by weight: 20-30 parts of goldthread root extract, 15-20 parts of balsam pear extract, 12-20 parts of mint, 0.2-1 part of bendinalinium, 0.1-0.5 part of citric acid and 10-15 parts of cellulose.
2. The water for treating onychomycosis according to claim 1, wherein the goldthread root extract is obtained from 10-20 parts by weight of goldthread root, and is added to 100-150 parts by weight of water, boiled for 0.2-1 hour, cooled to room temperature, and filtered to obtain a filtrate.
3. The water for treating onychomycosis according to claim 1, wherein fresh balsam pear is adopted as the balsam pear extract, the balsam pear extract is dried, ground into balsam pear powder, the balsam pear powder is mixed with water, the mass ratio of the balsam pear powder to the water is 1:4, the balsam pear powder liquid is filtered, the filtrate is subjected to ultrasonic treatment and then is heated to 75-100 ℃ for extraction for more than 2 hours, and after the extraction is finished, the temperature is reduced to room temperature, and the balsam pear extract is obtained through centrifugation and filtration.
4. The water according to claim 1, wherein the mint is mint essential oil or contains menthol and derivatives thereof, the cellulose is microcrystalline cellulose, and the grain size of the microcrystalline cellulose is 15-35 μm.
5. A method for preparing water for treating onychomycosis is characterized by comprising the following steps,
s1, mixing the goldthread root extract, the balsam pear extract, the mint, the bendinalinium and the cellulose according to the weight part ratio;
s2, adding water into the mixed mixture, adding 2-5 times of water, mixing, and soaking for 30-45 minutes to obtain a mixed solution;
s3, boiling the mixed solution obtained in the step II for 20-30 minutes, filtering the mixed solution, and collecting the obtained filtrate;
s4, cooling the filtrate, adding citric acid into the filtrate after cooling, stirring and heating, standing at 60-80 ℃ for 15-20 minutes, taking the supernatant, concentrating under reduced pressure, centrifuging, filtering, and collecting the filtrate to obtain the water of the scabrous doellingeria herb.
6. The method for preparing water for treating onychomycosis according to claim 5, wherein the concentrated acid is at 40-80 deg.C and 0.04-0.10 Mpa, and is concentrated to 10-40% of the original volume.
7. The method for preparing water for treating onychomycosis according to claim 5, wherein the water for treating onychomycosis in step four is applied to children's hands uniformly 3 times a day.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011263030.3A CN112353846A (en) | 2020-11-12 | 2020-11-12 | A nail polish remover and its preparation method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202011263030.3A CN112353846A (en) | 2020-11-12 | 2020-11-12 | A nail polish remover and its preparation method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112870249A (en) * | 2021-03-08 | 2021-06-01 | 陆猛 | Preparation method of food retardant |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101461514A (en) * | 2009-01-22 | 2009-06-24 | 韩金光 | Bitter melon extract and preparation method thereof |
| CN102846670A (en) * | 2011-07-01 | 2013-01-02 | 杨万良 | Biological medicament for treating finger biting addiction |
| CN106692430A (en) * | 2016-12-13 | 2017-05-24 | 安徽银龙泵阀股份有限公司 | External formula liquid for treating children's fingernail biting |
-
2020
- 2020-11-12 CN CN202011263030.3A patent/CN112353846A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101461514A (en) * | 2009-01-22 | 2009-06-24 | 韩金光 | Bitter melon extract and preparation method thereof |
| CN102846670A (en) * | 2011-07-01 | 2013-01-02 | 杨万良 | Biological medicament for treating finger biting addiction |
| CN106692430A (en) * | 2016-12-13 | 2017-05-24 | 安徽银龙泵阀股份有限公司 | External formula liquid for treating children's fingernail biting |
Non-Patent Citations (1)
| Title |
|---|
| 李燕梅: "5种方法让孩子不再啃指甲", 《家庭教育(幼儿家长)》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112870249A (en) * | 2021-03-08 | 2021-06-01 | 陆猛 | Preparation method of food retardant |
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