CN112335694A - High-activity benzalkonium chloride sterilization and disinfection spray, preparation method and device - Google Patents
High-activity benzalkonium chloride sterilization and disinfection spray, preparation method and device Download PDFInfo
- Publication number
- CN112335694A CN112335694A CN202011370914.9A CN202011370914A CN112335694A CN 112335694 A CN112335694 A CN 112335694A CN 202011370914 A CN202011370914 A CN 202011370914A CN 112335694 A CN112335694 A CN 112335694A
- Authority
- CN
- China
- Prior art keywords
- parts
- extract
- stirring
- benzalkonium chloride
- ultrasonic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
- A01N25/06—Aerosols
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/02—Acyclic compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
- A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/16—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/40—Liliopsida [monocotyledons]
- A01N65/42—Aloeaceae [Aloe family] or Liliaceae [Lily family], e.g. aloe, veratrum, onion, garlic or chives
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
- B01F27/90—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with paddles or arms
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
- C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
- C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Agronomy & Crop Science (AREA)
- Plant Pathology (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Dentistry (AREA)
- Chemical & Material Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Biotechnology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a high-activity benzalkonium chloride sterilizing and disinfecting spray, which comprises the following raw materials: ethanol, benzalkonium chloride, convallaria extract, pink extract, jasmine extract, violet extract, mixed essential oil, traditional Chinese medicine extract, spirulina francolin mixed fermentation liquor, chitosan derivative, silver ion colloid, compound quaternary ammonium salt, polyhexamethylene biguanide hydrochloride, fendorin and emulsifier, and also discloses a preparation method and a device of the disinfection spray, by adding benzalkonium chloride, the permeability of bacterial cytoplasmic membrane can be changed, the bacterial cytoplasmic substance is caused to exosmose, the metabolism is blocked, and the killing effect is achieved, by adding the lily of the valley extract, the dianthus chinensis extract, the jasmine extract and the violet extract, various plant components are utilized to carry out multi-species sterilization, so that the sterilization is more green and safe, the spirulina-francolin mixed fermentation liquor and the fendortin are cooperatively matched, so that the bactericidal activity of benzalkonium chloride can be further improved, and the bactericidal efficiency can be further improved.
Description
Technical Field
The invention relates to the technical field of disinfection spray, in particular to high-activity benzalkonium chloride disinfection spray, a preparation method and a device.
Background
The disinfection spray is used for disinfection, is widely used in life and medical treatment, can be used for disinfection treatment of masks under the existing new coronary pneumonia epidemic situation, and can also be used for disinfection of surgical operations in hospitals.
Benzalkonium chloride is known by the chemical name dimethylbenzyl ammonium chloride, a white waxy solid or a yellow colloid; the aqueous solution shows neutral or alkalescent reaction, and generates a large amount of foam when shaken. The product is very soluble in water or ethanol, and slightly soluble in diethyl ether.
Benzalkonium chloride is a cationic surfactant, is a broad-spectrum bactericide, but has moderate bactericidal strength, and has uncertain drug effect when being used as a bactericide for surgical instruments and heat-labile articles, so that a high-activity benzalkonium chloride sterilization and disinfection spray is needed.
Disclosure of Invention
The embodiment of the invention aims to provide a high-activity benzalkonium chloride sterilization and disinfection spray, a preparation method and a device, which aim to solve the problems.
In order to achieve the purpose, the invention provides the following technical scheme:
a high-activity benzalkonium chloride sterilization and disinfection spray comprises the following raw materials in parts by weight: 40-60 parts of ethanol, 2-4 parts of benzalkonium chloride, 20-30 parts of convallaria majalis extract, 10-20 parts of dianthus chinensis extract, 8-16 parts of jasmine extract, 10-16 parts of violet extract, 2-4 parts of mixed essential oil, 6-12 parts of traditional Chinese medicine extract, 20-30 parts of spirulina-malachite mixed fermentation liquor, 1-5 parts of chitosan derivative, 2-6 parts of silver ion colloid, 1-3 parts of compound quaternary ammonium salt, 1-3 parts of polyhexamethylene biguanide hydrochloride, 3-7 parts of fendorin and 1-2 parts of emulsifier.
In one alternative: the feed comprises the following raw materials in parts by weight: 45-55 parts of ethanol, 2.5-3.5 parts of benzalkonium chloride, 22-27 parts of convallaria majalis extract, 12-18 parts of dianthus chinensis extract, 10-14 parts of jasmine extract, 12-14 parts of violet extract, 2.5-3.5 parts of mixed essential oil, 7-11 parts of traditional Chinese medicine extract, 22-28 parts of spirulina-partridge mixed fermentation liquor, 2-4 parts of chitosan derivative, 3-5 parts of silver ion colloid, 1.5-2.5 parts of composite quaternary ammonium salt, 1.5-2.5 parts of polyhexamethylene biguanide hydrochloride, 4-6 parts of fendorin and 1.2-1.7 parts of emulsifier.
In one alternative: the feed comprises the following raw materials in parts by weight: 50 parts of ethanol, 3 parts of benzalkonium chloride, 25 parts of lily of the valley, 15 parts of a dianthus chinensis extracting solution, 12 parts of a jasmine extracting solution, 13 parts of a violet extracting solution, 3 parts of mixed essential oil, 9 parts of a traditional Chinese medicine extracting solution, 25 parts of a spirulina-francolin mixed fermentation liquid, 3 parts of a chitosan derivative, 4 parts of a silver ion colloid, 2 parts of a compound quaternary ammonium salt, 2 parts of polyhexamethylene biguanide hydrochloride, 5 parts of fendorin and 1.5 parts of an emulsifier.
In one alternative: the preparation method of the convallaria majalis extracting solution comprises the following steps: adding deionized water 2-3 times the weight of the clean lily of the valley into the cleaned lily of the valley, heating the mixture to 70-80 ℃, preserving the heat for 1-2h under the stirring state, then placing the mixture into an ultrasonic container, carrying out ultrasonic treatment for 10-20min at the ultrasonic frequency of 20-40kHz and the output power of 150-.
In one alternative: the preparation method of the dianthus chinensis extracting solution comprises the following steps: taking the dianthus chinensis, cleaning, airing, crushing, putting into a percolator, percolating and extracting by adopting ethanol water solution with the weight of 8-10 times to obtain percolation extract and percolation extraction residues, adding the percolation extraction residues into ethanol water solution with the weight of 10-11 times, soaking for 2-3h, ultrasonically extracting for 20-30min, filtering to obtain ultrasonic extract and ultrasonic extraction residues, adding water with the weight of 9-10 times to the ultrasonic extraction residues, putting into a high-pressure kettle, decocting for 20-30min under high pressure, filtering to obtain high-pressure extract and high-pressure extraction residues, combining the percolation extract, the ultrasonic extract and the high-pressure extract, and evaporating and concentrating under reduced pressure to 20% of the original volume to obtain the dianthus chinensis extract.
In one alternative: the preparation method of the jasmine extracting solution comprises the following steps: adding 2-3 times of deionized water into cleaned flos Jasmini sambac, heating to 70-80 deg.C, maintaining the temperature for 1-2h under stirring, placing into an ultrasonic container with ultrasonic frequency of 20-40kHz and output power of 150-200W, performing ultrasonic treatment for 10-20min, cooling to room temperature, and extracting under reflux.
In one alternative: the preparation method of the violet extracting solution comprises the following steps: adding 2-3 times of deionized water into cleaned violet, heating to 70-80 deg.C, keeping the temperature for 1-2h under stirring, placing into an ultrasonic container with ultrasonic frequency of 20-40kHz and output power of 150 & lt- & gt 200 & gtW, performing ultrasonic treatment for 10-20min, cooling to room temperature, and performing reflux extraction.
In one alternative: the mixed essential oil is prepared from argy wormwood leaf essential oil, chamomile essential oil, eucalyptus robusta oil and the like.
In one alternative: the traditional Chinese medicine extracting solution is prepared from fructus ulmi, dandelion, fructus forsythiae, quisqualis and carpesium according to a weight ratio of 1: 3: (1-2): 1: 1, and mixing and extracting by a percolation method.
In one alternative: the preparation method of the chitosan derivative comprises the following steps: extracting chitin from crab shell, and preparing by conventional three-step method including acid leaching and desalting, alkali boiling and deproteinizing, and oxidation and decolorization; drying chitin in the sun, and removing acetyl under the action of concentrated alkali to obtain the chitosan derivative.
In one alternative: the preparation method of the spirulina-francolin mixed fermentation liquor comprises the following steps: cleaning spirulina and Mallotus oblongifolius, draining, grinding, mashing, placing into a reaction kettle, mixing, adjusting pH to 8-9, stirring in the reaction kettle while performing electron beam radiation treatment, wherein the electron beam radiation dose is controlled to be 1-3kGy, and the radiation time is 10-20 s; on one hand, the electron beam radiation can sterilize, on the other hand, the electron beam radiation directly acts on biomolecules, hydrogen bonds are broken, double bonds are oxidized, a ring structure is damaged, certain molecules are polymerized, and the like, so that the method is favorable for extracting effective components in spirulina and partridge vegetable, then lactobacillus delbrueckii is inoculated, the spirulina and partridge vegetable are subjected to sealed fermentation for 180-220 minutes at the constant temperature of 30-40 ℃, and the spirulina-partridge vegetable mixed fermentation liquor is obtained after high-temperature sterilization and filtration and impurity removal.
In one alternative: the emulsifier is a nonionic surfactant.
The preparation method of the high-activity benzalkonium chloride sterilizing and disinfecting spray comprises the following steps:
1) weighing the raw materials according to the proportion;
2) mixing ethanol, benzalkonium chloride, mixed essential oil, chitosan derivative, silver ion colloid, compound quaternary ammonium salt, polyhexamethylene biguanide hydrochloride and fendorin, and stirring at the rotation speed of 600-;
3) mixing the convallaria majalis extract, the dianthus chinensis extract, the jasmine extract, the violet extract, the traditional Chinese medicine extract and the spirulina-francolin mixed fermentation liquor, and stirring for 10-20min at the rotation speed of 400-600 rpm to prepare a mixed liquor B;
4) mixing the mixed solution A and the mixed solution B, stirring at 300 rpm for 20-30min, sterilizing with high pressure steam at 1.5Mpa and 120 deg.C for 1-2 hr, and bottling to obtain the final product.
Compared with the prior art, the embodiment of the invention has the following beneficial effects:
through adding benzalkonium chloride, can change bacterium cytoplasmic membrane permeability, make thallus cytoplasmic material exosmosis, hinder its metabolism and play the effect of killing, through adding the lily of the valley extract, the pink extract, jasmine extract, the violet extract, utilize multiple plant composition to carry out multiple type and disinfect, greener is safe, through adding mixed essential oil, not only can disinfect, can also provide fragrance, make people be relaxed and happy, through adding the traditional chinese medicine extract, especially synergistic interaction between fructus ulmi, dandelion, fructus forsythiae, the quisqualis, the carpesium, can kill multiple bacterium and improve bactericidal effect, through spirulina-mallotus oblongifolius mixed fermentation liquid and fendormin synergistic interaction, can further improve benzalkonium chloride's bactericidal activity, further improvement bactericidal efficiency.
Drawings
Fig. 1 is a schematic structural diagram of a sixth embodiment of the present invention.
Notations for reference numerals: 1-stirring barrel, 2-stirring rod, 3-magnet sleeve, 4-magnet block, 5-stirring support rod, 6-sliding sleeve, 7-extension spring, 8-motor, 9-stirring shaft, 10-limit retainer ring, 11-supporting leg, 12-self-locking roller, 13-feeding hopper and 14-discharging port.
Detailed Description
The present invention will be described in detail with reference to the following examples, which are provided for illustrative purposes only and are not intended to limit the scope of the present invention. Any obvious modifications or variations can be made to the present invention without departing from the spirit or scope of the present invention.
Example 1
Weighing the following raw materials in parts by weight: 40 parts of ethanol, 2 parts of benzalkonium chloride, 20 parts of a convallaria extract, 10 parts of a dianthus chinensis extract, 8 parts of a jasmine extract, 10 parts of a violet extract, 2 parts of mixed essential oil, 6 parts of a traditional Chinese medicine extract, 20 parts of a spirulina-francolin mixed fermentation liquid, 1 part of a chitosan derivative, 2 parts of a silver ion colloid, 1 part of a compound quaternary ammonium salt, 1 part of polyhexamethylene biguanide hydrochloride, 3 parts of fendorin and 1 part of an emulsifier, then mixing the ethanol, the benzalkonium chloride, the mixed essential oil, the chitosan derivative, the silver ion colloid, the compound quaternary ammonium salt, the polyhexamethylene biguanide hydrochloride and the fendorin, and stirring for 10min at the rotating speed of 600 revolutions per minute to prepare a mixed solution A; mixing herba Convallariae extractive solution, Caryophyllum extractive solution, flos Jasmini sambac extractive solution, herba Violae, Chinese medicinal extractive solution, and Spirulina-Caloglossa Leprieurii mixed fermentation liquid, stirring at 400 rpm for 10min to obtain mixed solution B; and finally, mixing the mixed solution A and the mixed solution B, stirring for 20min at the rotating speed of 300 revolutions per minute, sterilizing by high-pressure steam, wherein the sterilizing steam pressure is 1.5Mpa, the steam temperature is 120 ℃, the sterilizing time is 1h, and filling into bottles to obtain the required high-activity benzalkonium chloride sterilizing spray.
The preparation method of the convallaria majalis extracting solution comprises the following steps: adding deionized water 2 times the weight of the clean lily of the valley into the clean lily of the valley, heating the mixture to 70 ℃, preserving the heat for 1h under the stirring state, then putting the mixture into an ultrasonic container, carrying out ultrasonic treatment for 10min at the ultrasonic frequency of 20kHz and the output power of 150W, cooling the mixture to the room temperature, and then carrying out reflux extraction to obtain the lily of the valley.
The preparation method of the dianthus chinensis extracting solution comprises the following steps: taking the dianthus chinensis, cleaning, airing, crushing, putting into a percolator, percolating and extracting by using an ethanol water solution with the weight of 8 times to obtain a percolation extracting solution and percolation extracting residues, adding the percolation extracting residues into an ethanol water solution with the weight of 10 times, soaking for 2 hours, carrying out ultrasonic extraction for 20 minutes, filtering to obtain an ultrasonic extracting solution and ultrasonic extracting residues, adding water with the weight of 9 times into the ultrasonic extracting residues, putting into a high-pressure kettle, carrying out high-pressure decoction for 20 minutes, filtering to obtain a high-pressure extracting solution and high-pressure extracting residues, combining the percolation extracting solution, the ultrasonic extracting solution and the high-pressure extracting solution, and carrying out reduced-pressure evaporation and concentration to 20% of the original volume to obtain the dianthus.
The preparation method of the jasmine extracting solution comprises the following steps: adding 2 times of deionized water into cleaned flos Jasmini sambac, heating to 70 deg.C, maintaining the temperature for 1h under stirring, placing into an ultrasonic container with ultrasonic frequency of 20kHz and output power of 150W, performing ultrasonic treatment for 10min, cooling to room temperature, and reflux-extracting.
The preparation method of the violet extracting solution comprises the following steps: adding 2 times of deionized water into cleaned violet, heating to 70 deg.C, maintaining the temperature for 1h under stirring, placing into an ultrasonic container with ultrasonic frequency of 20kHz and output power of 150W, performing ultrasonic treatment for 10min, cooling to room temperature, and reflux-extracting.
The mixed essential oil is prepared from argy wormwood leaf essential oil, chamomile essential oil, eucalyptus robusta oil and the like.
The traditional Chinese medicine extracting solution is prepared from fructus ulmi, dandelion, fructus forsythiae, quisqualis and carpesium according to a weight ratio of 1: 3: 1: 1: 1, and mixing and extracting by a percolation method.
The preparation method of the chitosan derivative comprises the following steps: extracting chitin from crab shell, and preparing by conventional three-step method including acid leaching and desalting, alkali boiling and deproteinizing, and oxidation and decolorization; drying chitin in the sun, and removing acetyl under the action of concentrated alkali to obtain the chitosan derivative.
The preparation method of the spirulina-francolin mixed fermentation liquor comprises the following steps: cleaning spirulina and partridge vegetable, draining, grinding and mashing, putting into a reaction kettle for mixing, then adjusting the pH to 8, stirring in the reaction kettle while performing electron beam radiation treatment, wherein the electron beam radiation dose is controlled to be 1kGy, and the radiation time is 10 s; then inoculating lactobacillus delbrueckii, sealing and fermenting for 180 minutes at the constant temperature of 30 ℃, sterilizing at high temperature, and filtering to remove impurities to obtain the spirulina-francolin mixed fermentation liquor.
The emulsifier is a nonionic surfactant.
Example 2
Weighing the following raw materials in parts by weight: 45 parts of ethanol, 2.5 parts of benzalkonium chloride, 22 parts of convallaria majalis extract, 12 parts of dianthus chinensis extract, 10 parts of jasmine extract, 12 parts of violet extract, 2.5 parts of mixed essential oil, 7 parts of traditional Chinese medicine extract, 22 parts of spirulina-francolin mixed fermentation liquor, 2 parts of chitosan derivative, 3 parts of silver ion colloid, 1.5 parts of compound quaternary ammonium salt, 1.5 parts of polyhexamethylene biguanide hydrochloride, 4 parts of fendorin and 1.2 parts of emulsifier, then mixing the ethanol, the benzalkonium chloride, the mixed essential oil, the chitosan derivative, the silver ion colloid, the compound quaternary ammonium salt, the polyhexamethylene biguanide hydrochloride and the fendorin, and stirring for 12min at the rotating speed of 650 revolutions per minute to prepare mixed liquid A; mixing herba Convallariae extractive solution, Caryophyllum extractive solution, flos Jasmini sambac extractive solution, herba Violae, Chinese medicinal extractive solution, and Spirulina-Caloglossa Leprieurii mixed fermentation liquid, stirring at 450 rpm for 12min to obtain mixed solution B; and finally, mixing the mixed solution A and the mixed solution B, stirring for 23min at the rotating speed of 300 revolutions per minute, sterilizing by high-pressure steam, wherein the sterilizing steam pressure is 1.5Mpa, the steam temperature is 120 ℃, the sterilizing time is 1h, and filling into bottles to obtain the required high-activity benzalkonium chloride sterilizing spray.
The preparation method of the convallaria majalis extracting solution comprises the following steps: adding deionized water 2 times the weight of the clean lily of the valley into the clean lily of the valley, heating the mixture to 72 ℃, preserving the heat for 1h under the stirring state, then putting the mixture into an ultrasonic container, carrying out ultrasonic treatment for 13min at the ultrasonic frequency of 25kHz and the output power of 160W, cooling the mixture to the room temperature, and then carrying out reflux extraction to obtain the lily of the valley.
The preparation method of the dianthus chinensis extracting solution comprises the following steps: taking the dianthus chinensis, cleaning, airing, crushing, putting into a percolator, percolating and extracting by using an ethanol water solution with the weight of 8 times to obtain a percolation extracting solution and percolation extracting residues, adding the percolation extracting residues into an ethanol water solution with the weight of 10 times, soaking for 2 hours, carrying out ultrasonic extraction for 22min, filtering to obtain an ultrasonic extracting solution and ultrasonic extracting residues, adding water with the weight of 9 times into the ultrasonic extracting residues, putting into a high-pressure kettle, carrying out high-pressure decoction for 23min, filtering to obtain a high-pressure extracting solution and high-pressure extracting residues, combining the percolation extracting solution, the ultrasonic extracting solution and the high-pressure extracting solution, and carrying out reduced-pressure evaporation and concentration to 20% of the original volume to obtain the dianthus.
The preparation method of the jasmine extracting solution comprises the following steps: adding 2 times of deionized water into cleaned flos Jasmini sambac, heating to 72 deg.C, maintaining the temperature for 1h under stirring, placing into an ultrasonic container with ultrasonic frequency of 25kHz and output power of 160W, performing ultrasonic treatment for 13min, cooling to room temperature, and reflux-extracting.
The preparation method of the violet extracting solution comprises the following steps: adding 2 times of deionized water into cleaned violet, heating to 72 deg.C, maintaining the temperature for 1h under stirring, placing into an ultrasonic container with ultrasonic frequency of 25kHz and output power of 160W, performing ultrasonic treatment for 13min, cooling to room temperature, and reflux-extracting.
The mixed essential oil is prepared from argy wormwood leaf essential oil, chamomile essential oil, eucalyptus robusta oil and the like.
The traditional Chinese medicine extracting solution is prepared from fructus ulmi, dandelion, fructus forsythiae, quisqualis and carpesium according to a weight ratio of 1: 3: 1: 1: 1, and mixing and extracting by a percolation method.
The preparation method of the chitosan derivative comprises the following steps: extracting chitin from crab shell, and preparing by conventional three-step method including acid leaching and desalting, alkali boiling and deproteinizing, and oxidation and decolorization; drying chitin in the sun, and removing acetyl under the action of concentrated alkali to obtain the chitosan derivative.
The preparation method of the spirulina-francolin mixed fermentation liquor comprises the following steps: cleaning spirulina and partridge vegetable, draining, grinding and mashing, putting into a reaction kettle, mixing, adjusting pH to 8, stirring in the reaction kettle while performing electron beam radiation treatment, wherein the electron beam radiation dose is controlled to be 1kGy, and the radiation time is 12 s; then inoculating lactobacillus delbrueckii, sealing and fermenting for 180-.
The emulsifier is a nonionic surfactant.
Example 3
Weighing the following raw materials in parts by weight: 50 parts of ethanol, 3 parts of benzalkonium chloride, 25 parts of a convallaria extract, 15 parts of a dianthus chinensis extract, 12 parts of a jasmine extract, 13 parts of a violet extract, 3 parts of mixed essential oil, 9 parts of a traditional Chinese medicine extract, 25 parts of a spirulina-francolin mixed fermentation liquid, 3 parts of a chitosan derivative, 4 parts of a silver ion colloid, 2 parts of a compound quaternary ammonium salt, 2 parts of polyhexamethylene biguanide hydrochloride, 5 parts of fendorin and 1.5 parts of an emulsifier, then mixing the ethanol, the benzalkonium chloride, the mixed essential oil, the chitosan derivative, the silver ion colloid, the compound quaternary ammonium salt, polyhexamethylene biguanide hydrochloride and the fendorin, and stirring for 15min at the rotation speed of 700 revolutions per minute to prepare a mixed liquid A; mixing herba Convallariae extractive solution, Caryophyllum extractive solution, flos Jasmini sambac extractive solution, herba Violae, Chinese medicinal extractive solution, and Spirulina-Caloglossa Leprieurii mixed fermentation liquid, stirring at 500 rpm for 15min to obtain mixed solution B; and finally, mixing the mixed solution A and the mixed solution B, stirring for 25min at the rotating speed of 300 revolutions per minute, sterilizing by high-pressure steam, wherein the sterilizing steam pressure is 1.5Mpa, the steam temperature is 120 ℃, the sterilizing time is 1.5h, and filling into bottles to obtain the required high-activity benzalkonium chloride sterilizing spray.
The preparation method of the convallaria majalis extracting solution comprises the following steps: adding deionized water 2.5 times the weight of the clean lily of the valley into the clean lily of the valley, heating the mixture to 75 ℃, preserving the heat for 1.5h under the stirring state, then placing the mixture into an ultrasonic container, carrying out ultrasonic treatment for 15min at the ultrasonic frequency of 30kHz and the output power of 175W, cooling the mixture to the room temperature, and then carrying out reflux extraction to obtain the lily of the valley.
The preparation method of the dianthus chinensis extracting solution comprises the following steps: taking the dianthus chinensis, cleaning, airing, crushing, putting into a percolator, percolating and extracting by adopting ethanol water solution with the weight being 9 times that of the dianthus chinensis to obtain percolating extract and percolating and extracting residues, adding the percolating and extracting residues into ethanol water solution with the weight being 10.5 times that of the dianthus chinensis, soaking for 2.5h, carrying out ultrasonic extraction for 25min, filtering to obtain ultrasonic extract and ultrasonic extracting residues, adding the ultrasonic extracting residues into water with the weight being 9.5 times that of the ultrasonic extracting residues, putting into a high-pressure kettle, carrying out high-pressure decoction for 25min, filtering to obtain high-pressure extract and high-pressure extracting residues, combining the percolating extract, the ultrasonic extract and the high-pressure extract, and carrying out reduced-pressure evaporation and concentration to 20% of.
The preparation method of the jasmine extracting solution comprises the following steps: adding 2.5 times of deionized water into cleaned flos Jasmini sambac, heating to 75 deg.C, maintaining the temperature for 1.5h under stirring, placing into an ultrasonic container with ultrasonic frequency of 30kHz and output power of 175W, treating with ultrasonic wave for 15min, cooling to room temperature, and reflux extracting.
The preparation method of the violet extracting solution comprises the following steps: adding 2.5 times of deionized water into cleaned violet, heating to 75 deg.C, maintaining the temperature for 1.5h under stirring, placing into an ultrasonic container with ultrasonic frequency of 30kHz and output power of 175W, treating with ultrasonic wave for 13min, cooling to room temperature, and reflux extracting.
The mixed essential oil is prepared from argy wormwood leaf essential oil, chamomile essential oil, eucalyptus robusta oil and the like.
The traditional Chinese medicine extracting solution is prepared from fructus ulmi, dandelion, fructus forsythiae, quisqualis and carpesium according to a weight ratio of 1: 3: 1.5: 1: 1, and mixing and extracting by a percolation method.
The preparation method of the chitosan derivative comprises the following steps: extracting chitin from crab shell, and preparing by conventional three-step method including acid leaching and desalting, alkali boiling and deproteinizing, and oxidation and decolorization; drying chitin in the sun, and removing acetyl under the action of concentrated alkali to obtain the chitosan derivative.
The preparation method of the spirulina-francolin mixed fermentation liquor comprises the following steps: cleaning spirulina and Mallotus oblongifolius, draining, grinding, mashing, placing into a reaction kettle, mixing, adjusting pH to 8.5, stirring in the reaction kettle while performing electron beam radiation treatment, wherein the electron beam radiation dose is controlled to be 2kGy, and the radiation time is 15 s; then inoculating lactobacillus delbrueckii, sealing and fermenting for 200 minutes at the constant temperature of 35 ℃, sterilizing at high temperature, and filtering to remove impurities to obtain the spirulina-francolin mixed fermentation liquor.
The emulsifier is a nonionic surfactant.
Example 4
Weighing the following raw materials in parts by weight: 55 parts of ethanol, 3.5 parts of benzalkonium chloride, 27 parts of convallaria majalis extract, 18 parts of dianthus chinensis extract, 14 parts of jasmine extract, 14 parts of violet extract, 3.5 parts of mixed essential oil, 11 parts of traditional Chinese medicine extract, 28 parts of spirulina-francolin mixed fermentation liquor, 4 parts of chitosan derivative, 5 parts of silver ion colloid, 2.5 parts of compound quaternary ammonium salt, 2.5 parts of polyhexamethylene biguanide hydrochloride, 6 parts of fendorin and 1.7 parts of emulsifier, then mixing the ethanol, the benzalkonium chloride, the mixed essential oil, the chitosan derivative, the silver ion colloid, the compound quaternary ammonium salt, polyhexamethylene biguanide hydrochloride and the fendorin, and stirring for 18min at the rotating speed of 750 revolutions per minute to prepare mixed liquid A; mixing the convallaria majalis extract, the dianthus chinensis extract, the jasmine extract, the violet extract, the traditional Chinese medicine extract and the spirulina-francolin mixed fermentation liquor, and stirring for 18min at the rotation speed of 550 revolutions per minute to prepare a mixed liquor B; and finally, mixing the mixed solution A and the mixed solution B, stirring for 28min at the rotating speed of 300 revolutions per minute, sterilizing by high-pressure steam, wherein the sterilizing steam pressure is 1.5Mpa, the steam temperature is 120 ℃, the sterilizing time is 2h, and filling into bottles to obtain the required high-activity benzalkonium chloride sterilizing spray.
The preparation method of the convallaria majalis extracting solution comprises the following steps: adding deionized water 3 times the weight of the clean lily of the valley into the clean lily of the valley, heating the mixture to 78 ℃, preserving the heat for 2 hours under the stirring state, then putting the mixture into an ultrasonic container, carrying out ultrasonic treatment for 18 minutes at the ultrasonic frequency of 35kHz and the output power of 190W, cooling the mixture to room temperature, and then carrying out reflux extraction to obtain the lily of the valley.
The preparation method of the dianthus chinensis extracting solution comprises the following steps: taking the dianthus chinensis, cleaning, airing, crushing, putting into a percolator, percolating and extracting by adopting 10 times of weight of ethanol water solution to obtain a percolation extracting solution and percolation extracting residues, adding the percolation extracting residues into 11 times of weight of ethanol water solution, soaking for 3 hours, carrying out ultrasonic extraction for 28min, filtering to obtain an ultrasonic extracting solution and ultrasonic extracting residues, adding 10 times of weight of water into the ultrasonic extracting residues, putting into a high-pressure kettle, carrying out high-pressure decoction for 28min, filtering to obtain a high-pressure extracting solution and high-pressure extracting residues, combining the percolation extracting solution, the ultrasonic extracting solution and the high-pressure extracting solution, and carrying out reduced-pressure evaporation and concentration to 20% of the original volume to obtain the dianthus chinensis extracting solution.
The preparation method of the jasmine extracting solution comprises the following steps: adding 3 times of deionized water into cleaned flos Jasmini sambac, heating to 78 deg.C, maintaining the temperature for 2 hr under stirring, placing into an ultrasonic container with ultrasonic frequency of 35kHz and output power of 190W, ultrasonic treating for 18min, cooling to room temperature, and reflux extracting.
The preparation method of the violet extracting solution comprises the following steps: adding 3 times of deionized water into cleaned violet, heating to 78 deg.C, maintaining the temperature for 2h under stirring, placing into an ultrasonic container with ultrasonic frequency of 35kHz and output power of 190W, performing ultrasonic treatment for 18min, cooling to room temperature, and reflux-extracting.
The mixed essential oil is prepared from argy wormwood leaf essential oil, chamomile essential oil, eucalyptus robusta oil and the like.
The traditional Chinese medicine extracting solution is prepared from fructus ulmi, dandelion, fructus forsythiae, quisqualis and carpesium according to a weight ratio of 1: 3: 2: 1: 1, and mixing and extracting by a percolation method.
The preparation method of the chitosan derivative comprises the following steps: extracting chitin from crab shell, and preparing by conventional three-step method including acid leaching and desalting, alkali boiling and deproteinizing, and oxidation and decolorization; drying chitin in the sun, and removing acetyl under the action of concentrated alkali to obtain the chitosan derivative.
The preparation method of the spirulina-francolin mixed fermentation liquor comprises the following steps: cleaning spirulina and Mallotus oblongifolius, draining, grinding, mashing, placing into a reaction kettle, mixing, adjusting pH to 8-9, stirring in the reaction kettle while performing electron beam radiation treatment, wherein the electron beam radiation dose is controlled to be 3kGy, and the radiation time is 18 s; then inoculating lactobacillus delbrueckii, sealing and fermenting for 210 minutes at the constant temperature of 38 ℃, sterilizing at high temperature, and filtering to remove impurities to obtain the spirulina-francolin mixed fermentation liquor.
The emulsifier is a nonionic surfactant.
Example 5
Weighing the following raw materials in parts by weight: 60 parts of ethanol, 4 parts of benzalkonium chloride, 30 parts of lily of the valley, 20 parts of a dianthus chinensis extracting solution, 16 parts of a jasmine extracting solution, 16 parts of a violet extracting solution, 4 parts of mixed essential oil, 12 parts of a traditional Chinese medicine extracting solution, 30 parts of a spirulina-francolin mixed fermentation liquid, 5 parts of a chitosan derivative, 6 parts of a silver ion colloid, 3 parts of a compound quaternary ammonium salt, 3 parts of polyhexamethylene biguanide hydrochloride, 7 parts of fendormin and 2 parts of an emulsifier, then mixing the ethanol, the benzalkonium chloride, the mixed essential oil, the chitosan derivative, the silver ion colloid, the compound quaternary ammonium salt, polyhexamethylene biguanide hydrochloride and the fendormin, and stirring for 20min at the rotating speed of 800 revolutions per minute to prepare a mixed solution A; mixing herba Convallariae extractive solution, Caryophyllum extractive solution, flos Jasmini sambac extractive solution, herba Violae, Chinese medicinal extractive solution, and Spirulina-Caloglossa Leprieurii mixed fermentation liquid, stirring at 600 rpm for 20min to obtain mixed solution B; and finally, mixing the mixed solution A and the mixed solution B, stirring for 30min at the rotating speed of 300 revolutions per minute, sterilizing by high-pressure steam, wherein the sterilizing steam pressure is 1.5Mpa, the steam temperature is 120 ℃, the sterilizing time is 2h, and filling into bottles to obtain the required high-activity benzalkonium chloride sterilizing spray.
The preparation method of the convallaria majalis extracting solution comprises the following steps: adding deionized water 3 times the weight of the clean lily of the valley into the clean lily of the valley, heating the mixture to 80 ℃, preserving the heat for 2 hours under the stirring state, then putting the mixture into an ultrasonic container, carrying out ultrasonic treatment for 20 minutes at the ultrasonic frequency of 40kHz and the output power of 200W, cooling the mixture to the room temperature, and then carrying out reflux extraction to obtain the lily of the valley.
The preparation method of the dianthus chinensis extracting solution comprises the following steps: taking the dianthus chinensis, cleaning, airing, crushing, putting into a percolator, percolating and extracting by adopting 10 times of weight of ethanol water solution to obtain a percolation extracting solution and percolation extracting residues, adding the percolation extracting residues into 11 times of weight of ethanol water solution, soaking for 3 hours, carrying out ultrasonic extraction for 30min, filtering to obtain an ultrasonic extracting solution and ultrasonic extracting residues, adding 10 times of weight of water into the ultrasonic extracting residues, putting into a high-pressure kettle, carrying out high-pressure decoction for 30min, filtering to obtain a high-pressure extracting solution and high-pressure extracting residues, combining the percolation extracting solution, the ultrasonic extracting solution and the high-pressure extracting solution, and carrying out reduced-pressure evaporation and concentration to 20% of the original volume to obtain the dianthus chinensis extracting solution.
The preparation method of the jasmine extracting solution comprises the following steps: adding 3 times of deionized water into cleaned flos Jasmini sambac, heating to 80 deg.C, maintaining the temperature for 2 hr under stirring, placing into an ultrasonic container with ultrasonic frequency of 40kHz and output power of 200W, ultrasonic treating for 20min, cooling to room temperature, and reflux extracting.
The preparation method of the violet extracting solution comprises the following steps: adding 3 times of deionized water into cleaned violet, heating to 80 deg.C, maintaining the temperature for 2h under stirring, placing into an ultrasonic container with ultrasonic frequency of 40kHz and output power of 200W, performing ultrasonic treatment for 20min, cooling to room temperature, and reflux-extracting.
The mixed essential oil is prepared from argy wormwood leaf essential oil, chamomile essential oil, eucalyptus robusta oil and the like.
The traditional Chinese medicine extracting solution is prepared from fructus ulmi, dandelion, fructus forsythiae, quisqualis and carpesium according to a weight ratio of 1: 3: 2: 1: 1, and mixing and extracting by a percolation method.
The preparation method of the chitosan derivative comprises the following steps: extracting chitin from crab shell, and preparing by conventional three-step method including acid leaching and desalting, alkali boiling and deproteinizing, and oxidation and decolorization; drying chitin in the sun, and removing acetyl under the action of concentrated alkali to obtain the chitosan derivative.
The preparation method of the spirulina-francolin mixed fermentation liquor comprises the following steps: cleaning spirulina and partridge vegetable, draining, grinding and mashing, putting into a reaction kettle, mixing, adjusting pH to 9, stirring in the reaction kettle while performing electron beam radiation treatment, wherein the electron beam radiation dose is controlled to be 3kGy, and the radiation time is 20 s; then inoculating lactobacillus delbrueckii, sealing and fermenting for 220 minutes at the constant temperature of 40 ℃, sterilizing at high temperature, and filtering to remove impurities to obtain the spirulina-francolin mixed fermentation liquor.
The emulsifier is a nonionic surfactant.
Example 6
A device for preparing high-activity benzalkonium chloride sterilization, disinfection and spraying comprises a stirring barrel 1 and a stirring mechanism, wherein a supporting leg 11 is fixed at the bottom of the stirring barrel 1, a self-locking roller 12 is installed at the bottom end of the supporting leg 11, the device is convenient to move, a feeding hopper 13 is arranged at the top of one side of the stirring barrel 1, a discharging port 14 is arranged at the bottom of one side of the stirring barrel 1, a valve is installed on the discharging port 14, the stirring mechanism comprises a motor 8, a stirring shaft 9, stirring rods 2, a sliding sleeve 6, a stirring rod 5 and a magnet sleeve 3, the stirring shaft 9 is vertically and rotatably installed in the stirring barrel 1, the motor 8 is fixedly installed at the top of the stirring barrel 1 and is in driving connection with the stirring shaft 9, the motor 8 is a variable speed motor 8, a plurality of stirring rods 2 are fixed on the stirring shaft 9 from top to bottom at intervals, the, the stretching spring 7 is preferably sleeved on the stirring rod 2, one end of the stirring rod 2, which is far away from the stirring shaft 9, is provided with a limiting check ring 10 for preventing the sliding sleeve 6 from being separated, the side wall of the sliding sleeve 6 is rotatably provided with two stirring support rods 5, the two stirring support rods 5 are arranged in a crossed manner, a compression spring is connected between the two stirring support rods 5, the stirring rod 2 is sleeved with a magnet sleeve 3, the thickness of the magnet sleeve 3 is gradually increased towards one side, which is far away from the stirring shaft 9, so that the magnetism is gradually enhanced, the end part, which is far away from the stirring shaft 9, of the two stirring support rods 5 is fixedly provided with a magnet block 4 with the same magnetic pole as that of the magnet sleeve 3, the motor 8 drives the stirring shaft 9 to rotate, the stirring rod 2 is driven by the stirring shaft 9 to rotate, the sliding sleeve 6 slides along the stirring rod 2 under the action of, the change of the relative position of the like magnetic block 4 and the magnet sleeve 3 enables the stirring support rod 5 to rotate different angles, so that the stirring range is enlarged, the stirring efficiency is improved, and the preparation effect is improved.
Comparative example 1
On the basis of the example 3, the spirulina-francolin mixed fermentation liquor is not contained;
comparative example 2
On the basis of example 3, no phytoncin is contained;
comparative example 3
On the basis of the example 3, the spirulina-francolin mixed fermentation liquor and the fendorin are not contained;
comparative example 4
On the basis of the embodiment 3, replacing the spirulina-francolin mixed fermentation liquor with the spirulina-francolin mixed extracting solution extracted by a percolation method;
comparative example 5
A commercially available disinfecting spray.
Test example, test sample for bacteriostatic effect test: bacteriostatic disinfectant sprays of examples 1-5, comparative examples 1-5; the test method comprises the following steps: escherichia coli, staphylococcus aureus, candida albicans and aspergillus niger are used as test strains, and the antibacterial effect test is carried out according to QB/T2850-2007 antibacterial and antibacterial detergent.
| Group of | E.coli/%) | Staphylococcus aureus/%) | Candida albicans/%) | Aspergillus niger/%) |
| Example 1 | 99.97 | 99.98 | 99.78 | 98.8 |
| Example 2 | 99.98 | 99.98 | 99.82 | 99.1 |
| Example 3 | 99.99 | 99.99 | 99.89 | 99.6 |
| Example 4 | 99.97 | 99.98 | 99.86 | 99.3 |
| Example 5 | 99.97 | 99.98 | 99.81 | 99.1 |
| Comparative example 1 | 71.6 | 74.1 | 73.4 | 72.4 |
| Comparative example 2 | 71.2 | 73.6 | 72.8 | 71.6 |
| Comparative example 3 | 50.8 | 52.5 | 56.1 | 55.3 |
| Comparative example 4 | 76.6 | 77.3 | 77.8 | 76.5 |
| Comparative example 5 | 50.3 | 51.5 | 55.1 | 54.3 |
From the results, the sterilization spray has good antibacterial and bactericidal effects, and especially, the fendorin and the spirulina-partridge mixed fermentation liquor are added to realize synergistic interaction, so that the antibacterial and bactericidal efficiency is greatly improved.
Through adding benzalkonium chloride, can change bacterium cytoplasmic membrane permeability, make thallus cytoplasmic material exosmosis, hinder its metabolism and play the killing effect, through adding the lily of the valley extract, the pink extract, jasmine extract, violet extract, utilize multiple plant composition to carry out multiple type and disinfect, greener is safe, through adding mixed essential oil, not only can disinfect, can also provide fragrance, make people be relaxed and happy, through adding the traditional chinese medicine extract, especially synergistic interaction between fructus ulmi, dandelion, fructus forsythiae, the quisqualis, carpesium, can kill multiple bacterium and improve bactericidal effect, through spirulina-mallotus furetianus mixed fermentation liquid and fendorin synergistic interaction, can further improve benzalkonium chloride's bactericidal activity, further improvement bactericidal efficiency
The above description is only for the specific embodiments of the present disclosure, but the scope of the present disclosure is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present disclosure, and all the changes or substitutions should be covered within the scope of the present disclosure. Therefore, the protection scope of the present disclosure shall be subject to the protection scope of the claims.
Claims (10)
1. The high-activity benzalkonium chloride sterilizing and disinfecting spray is characterized by comprising the following raw materials in parts by weight: 40-60 parts of ethanol, 2-4 parts of benzalkonium chloride, 20-30 parts of convallaria majalis extract, 10-20 parts of dianthus chinensis extract, 8-16 parts of jasmine extract, 10-16 parts of violet extract, 2-4 parts of mixed essential oil, 6-12 parts of traditional Chinese medicine extract, 20-30 parts of spirulina-malachite mixed fermentation liquor, 1-5 parts of chitosan derivative, 2-6 parts of silver ion colloid, 1-3 parts of compound quaternary ammonium salt, 1-3 parts of polyhexamethylene biguanide hydrochloride, 3-7 parts of fendorin and 1-2 parts of emulsifier.
2. The high-activity benzalkonium chloride sterilizing spray as claimed in claim 1, which comprises the following raw materials by weight: 45-55 parts of ethanol, 2.5-3.5 parts of benzalkonium chloride, 22-27 parts of convallaria majalis extract, 12-18 parts of dianthus chinensis extract, 10-14 parts of jasmine extract, 12-14 parts of violet extract, 2.5-3.5 parts of mixed essential oil, 7-11 parts of traditional Chinese medicine extract, 22-28 parts of spirulina-partridge mixed fermentation liquor, 2-4 parts of chitosan derivative, 3-5 parts of silver ion colloid, 1.5-2.5 parts of composite quaternary ammonium salt, 1.5-2.5 parts of polyhexamethylene biguanide hydrochloride, 4-6 parts of fendorin and 1.2-1.7 parts of emulsifier.
3. The high-activity benzalkonium chloride sterilizing spray as claimed in claim 2, which comprises the following raw materials in parts by weight: 50 parts of ethanol, 3 parts of benzalkonium chloride, 25 parts of lily of the valley, 15 parts of a dianthus chinensis extracting solution, 12 parts of a jasmine extracting solution, 13 parts of a violet extracting solution, 3 parts of mixed essential oil, 9 parts of a traditional Chinese medicine extracting solution, 25 parts of a spirulina-francolin mixed fermentation liquid, 3 parts of a chitosan derivative, 4 parts of a silver ion colloid, 2 parts of a compound quaternary ammonium salt, 2 parts of polyhexamethylene biguanide hydrochloride, 5 parts of fendorin and 1.5 parts of an emulsifier.
4. The spray for sterilizing and disinfecting high-activity benzalkonium chloride as claimed in claim 1, wherein the herba Convallariae extractive solution is prepared by the following steps: adding deionized water 2-3 times the weight of the clean lily of the valley into the cleaned lily of the valley, heating the mixture to 70-80 ℃, preserving the heat for 1-2h under the stirring state, then placing the mixture into an ultrasonic container, carrying out ultrasonic treatment for 10-20min at the ultrasonic frequency of 20-40kHz and the output power of 150-.
5. The spray for sterilizing and disinfecting high-activity benzalkonium chloride as claimed in claim 1, wherein the preparation method of the Caryophyllum extracting solution is as follows: taking the dianthus chinensis, cleaning, airing, crushing, putting into a percolator, percolating and extracting by adopting ethanol water solution with the weight of 8-10 times to obtain percolation extract and percolation extraction residues, adding the percolation extraction residues into ethanol water solution with the weight of 10-11 times, soaking for 2-3h, ultrasonically extracting for 20-30min, filtering to obtain ultrasonic extract and ultrasonic extraction residues, adding water with the weight of 9-10 times to the ultrasonic extraction residues, putting into a high-pressure kettle, decocting for 20-30min under high pressure, filtering to obtain high-pressure extract and high-pressure extraction residues, combining the percolation extract, the ultrasonic extract and the high-pressure extract, and evaporating and concentrating under reduced pressure to 20% of the original volume to obtain the dianthus chinensis extract.
6. The spray for sterilizing and disinfecting high-activity benzalkonium chloride as claimed in claim 1, wherein the preparation method of the jasmine extractive solution comprises the following steps: adding 2-3 times of deionized water into cleaned flos Jasmini sambac, heating to 70-80 deg.C, maintaining the temperature for 1-2h under stirring, placing into an ultrasonic container with ultrasonic frequency of 20-40kHz and output power of 150-200W, performing ultrasonic treatment for 10-20min, cooling to room temperature, and extracting under reflux.
7. The spray for sterilizing and disinfecting high-activity benzalkonium chloride as claimed in claim 1, wherein said violet extract is prepared by the following method: adding 2-3 times of deionized water into cleaned violet, heating to 70-80 deg.C, keeping the temperature for 1-2h under stirring, placing into an ultrasonic container with ultrasonic frequency of 20-40kHz and output power of 150 & lt- & gt 200 & gtW, performing ultrasonic treatment for 10-20min, cooling to room temperature, and performing reflux extraction.
8. The spray for sterilizing and disinfecting high-activity benzalkonium chloride as claimed in claim 1, wherein said mixed essential oil is prepared from folium Artemisiae Argyi essential oil, flos Matricariae Chamomillae essential oil, and Eucalyptus robusta oil.
9. The method for preparing the high-activity benzalkonium chloride disinfecting spray according to any one of claims 1-8, which comprises the following steps:
1) weighing the raw materials according to the proportion;
2) mixing ethanol, benzalkonium chloride, mixed essential oil, chitosan derivative, silver ion colloid, compound quaternary ammonium salt, polyhexamethylene biguanide hydrochloride and fendorin, and stirring at the rotation speed of 600-;
3) mixing the convallaria majalis extract, the dianthus chinensis extract, the jasmine extract, the violet extract, the traditional Chinese medicine extract and the spirulina-francolin mixed fermentation liquor, and stirring for 10-20min at the rotation speed of 400-600 rpm to prepare a mixed liquor B;
4) mixing the mixed solution A and the mixed solution B, stirring at 300 rpm for 20-30min, sterilizing with high pressure steam at 1.5Mpa and 120 deg.C for 1-2 hr, and bottling to obtain the final product.
10. The device applied to the preparation method of the high-activity benzalkonium chloride sterilization and disinfection spray as claimed in claim 9, which is characterized by comprising a stirring barrel (1) and a stirring mechanism, wherein the stirring mechanism comprises a motor (8), a stirring shaft (9), a stirring rod (2), a sliding sleeve (6), a stirring rod support (5) and a magnet sleeve (3), the stirring shaft (9) is vertically and rotatably installed in the stirring barrel (1), the motor (8) is fixedly installed at the top of the stirring barrel (1) and is in driving connection with the stirring shaft (9), the motor (8) is a variable speed motor (8), a plurality of stirring rods (2) are fixed on the stirring shaft (9) at intervals from top to bottom, the sliding sleeve (6) is movably sleeved on the stirring rod (2), an extension spring (7) is fixed between the sliding sleeve (6) and the stirring shaft (9), and a limit retaining ring (10) for preventing the sliding sleeve (6) from separating is arranged at one end of the stirring rod (2) far, rotate on sliding sleeve (6) lateral wall and install two stirring branch (5), two stirring branch (5) cross arrangement are connected with compression spring between two stirring branch (5), the cover is equipped with magnet cover (3) on puddler (2), and magnet cover (3) are to keeping away from one side thickness of (mixing) shaft (9) thickening gradually, two stirring branch (5) keep away from the end fixing of (mixing) shaft (9) have with the same sex magnet piece (4) of magnet cover (3) magnetic pole.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011370914.9A CN112335694A (en) | 2020-11-30 | 2020-11-30 | High-activity benzalkonium chloride sterilization and disinfection spray, preparation method and device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011370914.9A CN112335694A (en) | 2020-11-30 | 2020-11-30 | High-activity benzalkonium chloride sterilization and disinfection spray, preparation method and device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112335694A true CN112335694A (en) | 2021-02-09 |
Family
ID=74365174
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011370914.9A Pending CN112335694A (en) | 2020-11-30 | 2020-11-30 | High-activity benzalkonium chloride sterilization and disinfection spray, preparation method and device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112335694A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114634635A (en) * | 2022-03-28 | 2022-06-17 | 郑吉云 | Composite spherical polydimethylsiloxane, preparation method thereof and composition using composite spherical polydimethylsiloxane |
| WO2023159278A1 (en) * | 2022-02-28 | 2023-08-31 | Squire Kent Pty Limited | Anti-pathogenic aerosol compositions |
Citations (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140343158A1 (en) * | 2013-05-15 | 2014-11-20 | Normajean Fusco | Compositions for topical treatment |
| CN106581654A (en) * | 2016-12-27 | 2017-04-26 | 青岛琛蓝海洋生物工程有限公司 | Composite skin wound disinfectant and preparation method thereof |
| CN106793784A (en) * | 2014-03-10 | 2017-05-31 | 纽约市哥伦比亚大学理事会 | Vegetalitas antimicrobial compositions |
| CN107712487A (en) * | 2017-10-19 | 2018-02-23 | 百奥森（江苏）食品安全科技有限公司 | A kind of oriental cherry Armillariella mellea beverage production smashes sauce device with mixing |
| CN107899469A (en) * | 2017-12-19 | 2018-04-13 | 无锡市飞天油脂有限公司 | A kind of agitating device of OIL IN LUBRICATING OIL PRODUCTION processing |
| CN108056116A (en) * | 2017-12-14 | 2018-05-22 | 深圳市宜丽环保科技股份有限公司 | A kind of toilet flavor-absorbing disinfecting spray and preparation method thereof |
| CN108607429A (en) * | 2018-05-19 | 2018-10-02 | 章慧 | A kind of damping type industrial chemicals agitating device |
| CN207929067U (en) * | 2017-12-13 | 2018-10-02 | 无锡威克莱科技有限公司 | A kind of powder extrusion device of mill reparation |
| CN108991040A (en) * | 2018-07-11 | 2018-12-14 | 张培磊 | A kind of efficient mosquito repelling champignon liquid and preparation method thereof |
| CN109647247A (en) * | 2017-10-10 | 2019-04-19 | 陈丽贞 | A kind of rice flour production blender convenient for cleaning |
| CN210145884U (en) * | 2019-04-26 | 2020-03-17 | 广东联合宝莹生物科技有限公司 | Isocetyl stearyl acyloxy stearate prepares and uses mixing apparatus |
| CN111171723A (en) * | 2018-11-09 | 2020-05-19 | 万喜人家(北京)健康科技有限公司 | Preparation method and preparation equipment of shell powder dry powder type coating with mesh-hole polymer as film forming material |
| CN111346547A (en) * | 2020-03-24 | 2020-06-30 | 杭州酿蜜科技有限公司 | New material agitating unit that compounding is more even and automatic change |
| CN211329385U (en) * | 2019-12-10 | 2020-08-25 | 株洲三亿化学建材科技发展有限公司 | Polycarboxylate water reducing agent reation kettle |
| CN111616141A (en) * | 2020-08-03 | 2020-09-04 | 广州利众生物科技有限公司 | A wash-free antibacterial disinfecting spray containing fructus Litseae components and its preparation method |
| CN111789796A (en) * | 2020-04-28 | 2020-10-20 | 广东分子态生物股份有限公司 | Disinfectant with liposome-encapsulated bactericidal component and preparation method thereof |
-
2020
- 2020-11-30 CN CN202011370914.9A patent/CN112335694A/en active Pending
Patent Citations (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140343158A1 (en) * | 2013-05-15 | 2014-11-20 | Normajean Fusco | Compositions for topical treatment |
| CN106793784A (en) * | 2014-03-10 | 2017-05-31 | 纽约市哥伦比亚大学理事会 | Vegetalitas antimicrobial compositions |
| CN106581654A (en) * | 2016-12-27 | 2017-04-26 | 青岛琛蓝海洋生物工程有限公司 | Composite skin wound disinfectant and preparation method thereof |
| CN109647247A (en) * | 2017-10-10 | 2019-04-19 | 陈丽贞 | A kind of rice flour production blender convenient for cleaning |
| CN107712487A (en) * | 2017-10-19 | 2018-02-23 | 百奥森（江苏）食品安全科技有限公司 | A kind of oriental cherry Armillariella mellea beverage production smashes sauce device with mixing |
| CN207929067U (en) * | 2017-12-13 | 2018-10-02 | 无锡威克莱科技有限公司 | A kind of powder extrusion device of mill reparation |
| CN108056116A (en) * | 2017-12-14 | 2018-05-22 | 深圳市宜丽环保科技股份有限公司 | A kind of toilet flavor-absorbing disinfecting spray and preparation method thereof |
| CN107899469A (en) * | 2017-12-19 | 2018-04-13 | 无锡市飞天油脂有限公司 | A kind of agitating device of OIL IN LUBRICATING OIL PRODUCTION processing |
| CN108607429A (en) * | 2018-05-19 | 2018-10-02 | 章慧 | A kind of damping type industrial chemicals agitating device |
| CN108991040A (en) * | 2018-07-11 | 2018-12-14 | 张培磊 | A kind of efficient mosquito repelling champignon liquid and preparation method thereof |
| CN111171723A (en) * | 2018-11-09 | 2020-05-19 | 万喜人家(北京)健康科技有限公司 | Preparation method and preparation equipment of shell powder dry powder type coating with mesh-hole polymer as film forming material |
| CN210145884U (en) * | 2019-04-26 | 2020-03-17 | 广东联合宝莹生物科技有限公司 | Isocetyl stearyl acyloxy stearate prepares and uses mixing apparatus |
| CN211329385U (en) * | 2019-12-10 | 2020-08-25 | 株洲三亿化学建材科技发展有限公司 | Polycarboxylate water reducing agent reation kettle |
| CN111346547A (en) * | 2020-03-24 | 2020-06-30 | 杭州酿蜜科技有限公司 | New material agitating unit that compounding is more even and automatic change |
| CN111789796A (en) * | 2020-04-28 | 2020-10-20 | 广东分子态生物股份有限公司 | Disinfectant with liposome-encapsulated bactericidal component and preparation method thereof |
| CN111616141A (en) * | 2020-08-03 | 2020-09-04 | 广州利众生物科技有限公司 | A wash-free antibacterial disinfecting spray containing fructus Litseae components and its preparation method |
Non-Patent Citations (6)
| Title |
|---|
| 主编：吴开国: "《螺旋藻保健食品新资源和开发应用》", 30 November 1998, 南海出版公司 * |
| 主编：张美莉: "《食品功能成分的制备及其应用》", 31 January 2007, 中国轻工业出版社 * |
| 主编：秦松: "《中国海岸带植物资源》", 30 September 2013, 山东科学技术出版社 * |
| 主编：谢红: "《健康居家生活 绿色美家美容》", 3 September 2007, 东华大学出版社 * |
| 王慎明: "《芳香精油图鉴》", 30 April 2016, 山西科学技术出版社 * |
| 田景振 等: "《抗病毒中草药的研究与应用》", 30 April 2019, 山东科学技术出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023159278A1 (en) * | 2022-02-28 | 2023-08-31 | Squire Kent Pty Limited | Anti-pathogenic aerosol compositions |
| CN114634635A (en) * | 2022-03-28 | 2022-06-17 | 郑吉云 | Composite spherical polydimethylsiloxane, preparation method thereof and composition using composite spherical polydimethylsiloxane |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP2153838B1 (en) | Anti-norovirus agent, and composition comprising the same | |
| CN112335694A (en) | High-activity benzalkonium chloride sterilization and disinfection spray, preparation method and device | |
| CN110184135B (en) | Propolis bacteriostatic detergent and preparation method thereof | |
| CN109497106B (en) | Preparation method of foam disinfectant | |
| CN102754668A (en) | Novel Chinese herbal medicine compound disinfectant solution | |
| CN103053626B (en) | Natural lemon disinfectant and preparation method thereof | |
| CN106689966A (en) | Preparation method of natural food preservative | |
| CN110327222B (en) | Purely natural plant essential oil sterilization and disinfection wet tissue and preparation method thereof | |
| CN111264567A (en) | Sterilization disinfectant, preparation method and application thereof | |
| CN102349548A (en) | Environment biological disinfectant with phages as main components and application thereof | |
| CN110251580B (en) | Composite antibacterial agent and preparation method and application thereof | |
| KR102107772B1 (en) | Composition for cleaning dead skin | |
| CN105123783B (en) | A kind of Crazing in grassland culicifuge | |
| CN111345325A (en) | Method for preparing disinfectant by using Chinese herbal medicine brewing technology | |
| CN109362801A (en) | A kind of nanometer of animal and veterinary thimerosal and preparation method thereof | |
| JP2020033279A (en) | Anti-norovirus agent, disinfectant and cleaning agent | |
| CN104782675A (en) | Novel plant disease antibiotic agent and preparation method thereof | |
| CN111733026B (en) | Environment-friendly antibacterial laundry detergent | |
| CN106619335A (en) | Preparation method and application of green plum extract | |
| CN107714649B (en) | Oral spray for inhibiting oral pathogenic bacteria and application thereof | |
| CN112516237A (en) | Sterilization and deodorization spray for pets and preparation method thereof | |
| CN110692896A (en) | Natural preservative prepared by fermenting spice and preparation method thereof | |
| CN110917077A (en) | Natural plant bath foam | |
| CN103948540B (en) | A kind of compound disposable hand cleanser containing pig blood bacteriostatic agent and preparation method thereof | |
| CN108004068A (en) | A kind of dish washing detergent and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20210209 |
|
| RJ01 | Rejection of invention patent application after publication |