CN1123348C - Capsule for treating rheumatic and rheumatoid arthritis and its preparing process - Google Patents

Abstract

The present invention relates to medicine for treating rheumatoid arthritis and rheumarthritis, which is prepared by processing more than ten kinds of medicine, such as Chinese angelica, chuanxiong rhizome, achyranthes root, myrrh, pangolin, scorpion, silkworm larvae, licorice root, frankincense, etc. The medicine has the characteristics of easy producing process, reliable medical effect and no side effect.

Description

Capsule of treatment rheumatoid, rheumatic arthritis and preparation method thereof

The present invention relates to a kind of medicine for the treatment of rheumatoid disease and rheumatic arthritis, specifically it be a kind of be the capsule of feedstock production with Chinese medicine, the invention still further relates to the preparation method of this medicine.

Suffers from the rheumatoid patient, can bring long-term misery to patient because of arthralgia, and outbreak repeatedly with the variation of weather, can also make patient's limbs become deformity, so that disable, this disease has great harm to patient, this sick method of original treatment adopts Western medicine more, Western medicine easily has side effects, number of patent application is that 98110115 patent application discloses a kind of treatment rheumatism for this reason, the medicine of rheumatoid arthritis, this medicine is with Bungarus Parvus, Scorpio, Radix Cyathulae, Herba Ephedrae, ten multi-flavor medication preparation such as Semen Strychni form, this medicine has certain curative effect to rheumatism, but more because of containing drug toxicity, thus should strict control dose when taking, otherwise also easily cause untoward reaction.

The purpose of this invention is to provide and a kind ofly can treat diseases such as rheumatoid and rheumatic arthritis, and the Chinese patent medicine that has no side effect; And provide the preparation method of this medicine.

The objective of the invention is to be achieved through the following technical solutions:

A kind of medicine for the treatment of rheumatoid, rheumatic arthritis, it is to be made by following medicine and weight portion proportioning thereof:

20～25 parts of 30～40 parts of Radix Achyranthis Bidentataes of 35～45 parts of Rhizoma Chuanxiongs of Radix Angelicae Sinensis

30～35 parts of 40～45 portions of Scorpios of 15～25 parts of Squama Maniss of Myrrha

15～20 parts of 15～20 parts of Olibanums of 30～35 portions of Radix Glycyrrhizaes of Bombyx Batryticatus

25～30 parts of 30～35 parts of Os Canitis of 15～20 portions of Fructus Chaenomeliss of Lignum Aquilariae Resinatum

15～20 parts of 15～20 portions of Rhizoma Coptidis of Radix Ginseng 30～40 share tea

80～90 parts of 25～30 parts of Semen Strychni of 25～30 portions of Rhizoma Dioscoreae Nipponicae of Radix Angelicae Pubescentis

40～90 parts of the Radixs Astragali.

The medicine of described treatment rheumatoid, rheumatic arthritis, it is to be made by following medicine and weight portion proportioning thereof:

23～25 parts of 38～40 parts of Radix Achyranthis Bidentataes of 37～42 parts of Rhizoma Chuanxiongs of Radix Angelicae Sinensis

33～35 parts of 40～42 portions of Scorpios of 25 parts of Squama Maniss of Myrrha

20 parts of 18～20 parts of Olibanums of 35 portions of Radix Glycyrrhizaes of Bombyx Batryticatus

27～30 parts of 30～32 parts of Os Canitis of 18～19 portions of Fructus Chaenomeliss of Lignum Aquilariae Resinatum

15～20 parts of 15～18 portions of Rhizoma Coptidis of Radix Ginseng 35～40 share tea

80～90 parts of 28～30 parts of Semen Strychni of 25～27 portions of Rhizoma Dioscoreae Nipponicae of Radix Angelicae Pubescentis

75～85 parts of the Radixs Astragali

The medicine of described treatment rheumatoid, rheumatic arthritis, Radix Glycyrrhizae is produced by Shanxi Lu Anfu, and Radix Achyranthis Bidentatae, Fructus Chaenomelis, Rhizoma Coptidis are produced by Sichuan.

After taking by weighing the medicine that totally meets pharmaceutical grades by proportioning:

A, the following processing of medical material in will preparing burden is promptly earlier: Radix Angelicae Sinensis is concocted with wine, and Rhizoma Chuanxiong moistens through wine, and Myrrha, Olibanum were steeped 72 hours with wine respectively, and Squama Manis is concocted routinely, and the Radix Glycyrrhizae and the Radix Astragali are through processed with honey, and Os Canitis and Semen Strychni are concocted through stir-baking in sand respectively;

B, the Radix Angelicae Sinensis with the above-mentioned process of preparing Chinese medicine, Rhizoma Chuanxiong, Myrrha, Olibanum, Squama Manis, Radix Glycyrrhizae, Scorpio, Bombyx Batryticatus heated 30～40 minutes under 32 ℃～40 ℃ temperature, then pulverized 120 mesh sieves;

C, will under 35 ℃～40 ℃ temperature, heat 30～40 minutes, then pulverize, cross 120 mesh sieves through the Fructus Chaenomelis after Os Canitis, Semen Strychni, the Radix Astragali, Lignum Aquilariae Resinatum, Radix Ginseng, catechu, Rhizoma Coptidis, Radix Angelicae Pubescentis, Rhizoma Dioscoreae Nipponicae and the enucleation of the above-mentioned process of preparing Chinese medicine;

D, all medicines after crushed are gentle and stir puts into sterilizing room and parked under 35 ℃ 50～70 minutes.

The capsule of packing into of the medicine branch after the above-mentioned pulverizing, every capsules should heavy 0.5 gram.

In this medicine:

Radix Angelicae Sinensis: Main Ingredients and Appearance is a n-butene skin lactone, also contains vitamin B ₁₂, vitamin E etc., have enrich blood, the effect of promoting blood circulation and stopping pain;

Rhizoma Chuanxiong: contain ferulic acid, its rhizome contains volatilization wet goods composition, and it has the spasmolytic effect to smooth muscle;

Radix Achyranthis Bidentatae: have dispel the wind, dampness removing, the effect of stimulating the menstrual flow, invigorate blood circulation, can treat rheumatism lumbocrural pain and foot fistula clonic spasm of the muscle;

Scorpio: blood vessel dilating is arranged, suppress cardiomotility, can lower adrenal pressurization;

Olibanum, Myrrha: have dredge the meridian passage, prevent the effect that ecchymosis forms;

Bombyx Batryticatus: contain resistance attitude active hormones, but detoxicating and resolving stagnation of pathogens;

Radix Glycyrrhizae: contain Radix Glycyrrhizae dulcin or calcium salt, have stronger detoxifcation, anti-inflammatory and allergy;

Rhizoma Coptidis: have antibacterial and the coronary artery dilator effect;

Radix Ginseng: contain ginsenoside A, B, C, P, E and F, panoxadiol, panaxatriol, the ratio of plasma albumin and globulin is risen, the hemopoietic organ pipe improves the anemia effect;

Catechu: can hold back skin ulcer, promoting regeneration of the tissue and arresting bleeding by removing dampness;

Fructus Chaenomelis: contain the effect that vitamin C has suppressing the hyperactive liver stomach alive, damp eliminating numbness;

Semen Strychni: can facilitating digestion and endocrine, have and open meridians, reach the effect in joint thoroughly;

Rhizoma Dioscoreae Nipponicae: can relieving spasm to stop pain, similar functions of hormones is arranged;

Squama Manis: have promoting blood circulation to remove obstruction in the collateral, reducing swelling and alleviating pain, the function of the arthralgia chiefly caused by damp pathogen of dispeling the wind;

Lignum Aquilariae Resinatum: the warming middle-JIAO of regulating the flow of vital energy, warming the kidney improving inspiration by invigorating kidney-QI, the waist knee joint cold caused by deficiency of dispelling;

Os Canitis: energy blood activating and promoting tissue regeneration, dispelling the wind and dampness pathogens pain and numb limbs and tense tendons have remarkable inhibitory action to arthritis;

The Radix Astragali: make the expansion of whole body peripheral vessel, improve the effect of peripheral blood circulation.

The medicine that these medicines are prepared into through suitably preparation and special processing, have benefiting QI for activating blood circulation, promote endocrine, raise immunity, inhibition do not have bacteria disease and allergy, open meridians, reach joint, spasmolysis and analgesia thoroughly, make peripheral vessel expansion, make blood circulation unimpeded and the effect of reconciling function arranged.

For showing that this medicine is to rheumatoid therapeutic effect, once 315 routine patients were carried out clinical treatment and observation, rheumatoid patient is 165 examples, male's 90 examples wherein, women's 75 examples, all cases are by being divided into treatment group and matched group at 2: 1, and two groups all have comparability at age, sex, the course of disease, clinical setting, medicine among treatment group clothes and the present invention, matched group is taken piroxicam and B ₁, treatment time is four months.On inspection, treatment group total effective rate is 88%, follows the tracks of to follow up a case by regular visits to and learns efficacy consolidation in the treatment group.And the obvious effective rate of matched group is 79%, follows up a case by regular visits to and learns, the curative effect of matched group is not consolidated, and the patient has the phenomenon of falling ill once more.

Rheumatic arthritis is 150 examples, male's 90 examples wherein, women's 60 examples, this case was divided into treatment group and matched group by 2: 1 equally, and the treatment group is taken made medicine among the present invention, and matched group is taken ibuprofen, treatment time is three months, on inspection, treatment group effective percentage is 90%, and the matched group effective percentage is 70%.

In therapeutic process, clinical observation and laboratory examination are learnt, take the made medicine person of the present invention and do not have any untoward reaction and toxic and side effects.

Embodiment 1: press column weight amount proportioning and take by weighing the medicine that totally meets pharmaceutical grade:

20 kilograms of 40 kilograms of Radix Achyranthis Bidentataes of 35 kilograms of Rhizoma Chuanxiongs of Radix Angelicae Sinensis

35 kilograms of 40 kilograms of Scorpios of 25 kilograms of Squama Maniss of Myrrha

15 kilograms of 20 kilograms of Olibanums of 30 kilograms of Radix Glycyrrhizaes of Bombyx Batryticatus

25 kilograms of 35 kilograms of Os Canitis of 20 kilograms of Fructus Chaenomeliss of Lignum Aquilariae Resinatum

20 kilograms of 15 kilograms of Rhizoma Coptidis of 40 kilograms of catechu of Radix Ginseng

90 kilograms of 30 kilograms of Semen Strychni of 30 kilograms of Rhizoma Dioscoreae Nipponicae of Radix Angelicae Pubescentis

90 kilograms of the Radixs Astragali.

Then prepare patent medicine by following step and production method:

A, the following medicine in will preparing burden is concocted earlier:

Promptly Radix Angelicae Sinensis is concocted with wine, Rhizoma Chuanxiong moistens with wine, and Myrrha, Olibanum steeped 72 hours with wine respectively, and Squama Manis is concocted routinely, and the Radix Astragali and Radix Glycyrrhizae are through processed with honey, and Os Canitis and Semen Strychni are concocted through stir-baking in sand respectively;

B, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Myrrha, Olibanum, Squama Manis, Radix Glycyrrhizae with the above-mentioned process of preparing Chinese medicine, and Scorpio, Bombyx Batryticatus under 32 ℃～40 ℃ temperature, heated 30～40 minutes, then pulverized 120 mesh sieves;

C, will under 35 ℃～40 ℃ temperature, heat 30～40 minutes, then pulverize 120 mesh sieves through the Fructus Chaenomelis after Os Canitis, Semen Strychni, the Radix Astragali and Lignum Aquilariae Resinatum, Radix Ginseng, catechu, Rhizoma Coptidis, Radix Angelicae Pubescentis, Rhizoma Dioscoreae Nipponicae and the enucleation of the above-mentioned process of preparing Chinese medicine;

D, all medicines after crushed are mixed and stir puts into sterilizing room and parked 50～70 minutes under 35 ℃ of temperature, then divides the capsule of packing into, every capsules dose to weigh 0.5 and restrains.

Embodiment 2: press column weight amount proportioning and take by weighing the pure medicine that totally meets pharmaceutical grade:

50 kilograms of 60 kilograms of Radix Achyranthis Bidentataes of 90 kilograms of Rhizoma Chuanxiongs of Radix Angelicae Sinensis

60 kilograms of 90 kilograms of Scorpios of 30 kilograms of Squama Maniss of Myrrha

40 kilograms of 30 kilograms of Olibanums of 70 kilograms of Radix Glycyrrhizaes of Bombyx Batryticatus

60 kilograms of 60 kilograms of Os Canitis of 30 kilograms of Fructus Chaenomeliss of Lignum Aquilariae Resinatum

30 kilograms of 40 kilograms of Rhizoma Coptidis of 60 kilograms of catechu of Radix Ginseng

160 kilograms of 50 kilograms of Semen Strychni of 50 kilograms of Rhizoma Dioscoreae Nipponicae of Radix Angelicae Pubescentis

80 kilograms of the Radixs Astragali.

Then be prepared into medicine by embodiment 1 Chinese medicine preparation method.

Embodiment 3: take by weighing the pure medicine that meets pharmaceutical grades by following proportioning:

23 kilograms of 40 kilograms of Radix Achyranthis Bidentataes of 42 kilograms of Rhizoma Chuanxiongs of Radix Angelicae Sinensis

38 kilograms of 42 kilograms of Scorpios of 25 kilograms of Squama Maniss of Myrrha

20 kilograms of 20 kilograms of Olibanums of 35 kilograms of Radix Glycyrrhizaes of Bombyx Batryticatus

27 kilograms of 32 kilograms of Os Canitis of 19 kilograms of Fructus Chaenomeliss of Lignum Aquilariae Resinatum

20 kilograms of 18 kilograms of Rhizoma Coptidis of 35 kilograms of catechu of Radix Ginseng

80 kilograms of 28 kilograms of Semen Strychni of 27 kilograms of Rhizoma Dioscoreae Nipponicae of Radix Angelicae Pubescentis

75 kilograms of the Radixs Astragali.

Then make medicine by compounding method among the embodiment 1.

Embodiment 4: take by weighing pure and meet the medicine of pharmaceutical grades by following proportioning:

25 kilograms of 38 kilograms of Radix Achyranthis Bidentataes of 37 kilograms of Rhizoma Chuanxiongs of Radix Angelicae Sinensis

35 kilograms of 40 kilograms of Scorpios of 25 kilograms of Squama Maniss of Myrrha

20 kilograms of 18 kilograms of Olibanums of 35 kilograms of Radix Glycyrrhizaes of Bombyx Batryticatus

30 kilograms of 30 kilograms of Os Canitis of 18 kilograms of Fructus Chaenomeliss of Lignum Aquilariae Resinatum

20 kilograms of 15 kilograms of Rhizoma Coptidis of 40 kilograms of catechu of Radix Ginseng

90 kilograms of 30 kilograms of Semen Strychni of 25 kilograms of Rhizoma Dioscoreae Nipponicae of Radix Angelicae Pubescentis

85 kilograms of the Radixs Astragali.

Then make medicine according to the preparation method of embodiment 1.

Radix Achyranthis Bidentatae that is adopted in present embodiment 1～4 and Fructus Chaenomelis and Rhizoma Coptidis are produced by Sichuan, and Radix Glycyrrhizae is produced by Shanxi Province Lu Anfu.

Claims (5)

1, a kind of medicine for the treatment of rheumatoid, rheumatic arthritis is characterized in that: it is to be made by following medicine and weight portion proportioning thereof:

20～25 parts of 30～40 parts of Radix Achyranthis Bidentataes of 35～45 parts of Rhizoma Chuanxiongs of Radix Angelicae Sinensis

30～35 parts of 40～45 portions of Scorpios of 15～25 parts of Squama Maniss of Myrrha

15～20 parts of 15～20 parts of Olibanums of 30～35 portions of Radix Glycyrrhizaes of Bombyx Batryticatus

25～30 parts of 30～35 parts of Os Canitis of 15～20 portions of Fructus Chaenomeliss of Lignum Aquilariae Resinatum

15～20 parts of 15～20 portions of Rhizoma Coptidis of Radix Ginseng 30～40 share tea

80～90 parts of 25～30 parts of Semen Strychni of 25～30 portions of Rhizoma Dioscoreae Nipponicae of Radix Angelicae Pubescentis

40～90 parts of the Radixs Astragali.

2, the medicine of treatment rheumatoid according to claim 1, rheumatic arthritis is characterized in that: it is to be made by following medicine and weight portion proportioning thereof:

23～25 parts of 38～40 parts of Radix Achyranthis Bidentataes of 37～42 parts of Rhizoma Chuanxiongs of Radix Angelicae Sinensis

33～35 parts of 40～42 portions of Scorpios of 25 parts of Squama Maniss of Myrrha

20 parts of 18～20 parts of Olibanums of 35 portions of Radix Glycyrrhizaes of Bombyx Batryticatus

27～30 parts of 30～32 parts of Os Canitis of 18～19 portions of Fructus Chaenomeliss of Lignum Aquilariae Resinatum

15～20 parts of 15～18 portions of Rhizoma Coptidis of Radix Ginseng 35～40 share tea

80～90 parts of 28～30 parts of Semen Strychni of 25～27 portions of Rhizoma Dioscoreae Nipponicae of Radix Angelicae Pubescentis

75～85 parts of the Radixs Astragali.

3, the medicine of treatment rheumatoid according to claim 1 and 2, rheumatic arthritis, it is characterized in that: Radix Glycyrrhizae is produced by Shanxi Lu Anfu, and Radix Achyranthis Bidentatae, Fructus Chaenomelis, Rhizoma Coptidis are produced by Sichuan.

4, a kind of as the preparation method of medicine as described in the preparation claim 1 or 2 or 3, it is characterized in that: after taking by weighing the medicine that totally meets pharmaceutical grades by proportioning:

A, the following processing of medical material in will preparing burden is promptly earlier: Radix Angelicae Sinensis is concocted with wine, and Rhizoma Chuanxiong moistens through wine, and Myrrha, Olibanum were steeped 72 hours with wine respectively, and Squama Manis is concocted routinely, and the Radix Glycyrrhizae and the Radix Astragali are through processed with honey, and Os Canitis and Semen Strychni are concocted through stir-baking in sand respectively;

B, the Radix Angelicae Sinensis with the above-mentioned process of preparing Chinese medicine, Rhizoma Chuanxiong, Myrrha, Olibanum, Squama Manis, Radix Glycyrrhizae, Scorpio, Bombyx Batryticatus heated 30～40 minutes under 32 ℃～40 ℃ temperature, then pulverized 120 mesh sieves;

C, will under 35 ℃～40 ℃ temperature, heat 30～40 minutes, then pulverize, cross 120 mesh sieves through the Fructus Chaenomelis after Os Canitis, Semen Strychni, the Radix Astragali, Lignum Aquilariae Resinatum, Radix Ginseng, catechu, Rhizoma Coptidis, Radix Angelicae Pubescentis, Rhizoma Dioscoreae Nipponicae and the enucleation of the above-mentioned process of preparing Chinese medicine;

D, all medicines after crushed are gentle and stir puts into sterilizing room and parked under 35 ℃ 50～70 minutes.

5, preparation method according to claim 4 is characterized in that: the capsule of packing into of the medicine branch after the above-mentioned pulverizing, every capsules should heavy 0.5 gram.