CN112294790A - Immunity nutrient supplement and preparation method thereof - Google Patents

Immunity nutrient supplement and preparation method thereof Download PDF

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Publication number
CN112294790A
CN112294790A CN201910708365.2A CN201910708365A CN112294790A CN 112294790 A CN112294790 A CN 112294790A CN 201910708365 A CN201910708365 A CN 201910708365A CN 112294790 A CN112294790 A CN 112294790A
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China
Prior art keywords
mixing
glutamine
arginine
epa
discharging
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CN201910708365.2A
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Chinese (zh)
Inventor
杨国民
扈晓佳
段丽华
魏连山
秦似波
李珊
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Ningbo One Food Co ltd
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Ningbo One Food Co ltd
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Priority to CN201910708365.2A priority Critical patent/CN112294790A/en
Publication of CN112294790A publication Critical patent/CN112294790A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention aims to disclose an immune nutrient supplement and a preparation method thereof, wherein the immune nutrient supplement is prepared from the following components in percentage by mass: 60-70% of L-arginine, 10-20% of EPA and 20-30% of glutamine; compared with the prior art, the formula is reasonable in arrangement, the problems of malnutrition and the like which are caused by factors such as consumption of tumors, food intake obstruction, digestion obstruction, influence of the tumors on appetite, mental depression of patients and the like of malignant tumor patients in operative period and dyscrasia period and are characterized by weight reduction are solved, the design is reasonable, the production is easy, the control is convenient, and the purpose of the invention is realized.

Description

Immunity nutrient supplement and preparation method thereof
Technical Field
The invention relates to a nutrient supplement and a preparation method thereof, in particular to an immunonutrient supplement containing arginine, EPA and glutamine and a preparation method thereof.
Background
With the accelerating aging process of population and the change of life style, the incidence of chronic diseases such as tumor is obviously increased, and malignant tumor becomes one of the important diseases damaging human health in the 21 st century. The patients with tumor often have immune abnormality, metabolic disorder, malnutrition, dyscrasia and weight loss are common accompanying symptoms and signs, and treatment methods such as surgery, radiotherapy, chemotherapy and the like can cause gastrointestinal mucosa damage, barrier function weakening, intestinal flora change, further damage the immune system of the patients with tumor, aggravate malnutrition, cause curative effect reduction, increase incidence of infection and other complications, and aggravate the risk of relapse and death. Immune imbalance, inflammatory responses and metabolic abnormalities span the entire course of tumor development and progression.
The traditional nutritional support can only provide energy and nutritional substrates, maintain the nitrogen balance of the body and the structure and the function of tissues and organs, and is not enough to improve the nutritional status and the immune function of patients. Researches find that certain specific nutrient substances can improve the nutritional status of tumor patients and regulate the immune and inflammatory reactions of organisms, thereby realizing the effects of reducing infection and non-infection complications, shortening hospitalization time and improving treatment effect.
Arginine is a conditionally essential amino acid, an intermediate metabolite of the ornithine cycle, and a precursor for the biosynthesis of proteins, creatine, polyamines and nitric oxide. The production speed in vivo is slow, and when the body is in an acute stress state such as operation, burn and the like, arginine synthesized by the body is not enough to meet the metabolic demand, and the arginine needs to be supplemented from an exogenous way to meet the demands of tissue repair and cell growth. Arginine can promote the synthesis of protein and collagen, accelerate the healing of wound surface, promote the growth and differentiation of epithelial cells of new membrane, improve the structure of new membrane of intestine, maintain the barrier of intestinal mucosa and reduce the incidence of infection by stimulating the secretion of hormones such as insulin, growth hormone and the like.
EPA, namely eicosapentaenoic acid, is essential fatty acid of human body, belongs to omega-3 polyunsaturated fatty acid, and has the effects of (1) enhancing the immunity of the organism, and can inhibit inflammatory reaction of B lymphocyte, natural killer cell and macrophage. Competitively inhibits the combination of ARA with cyclooxygenase and lipoxygenase, preserves the integrity of cells, and has the functions of inhibiting inflammation and enhancing immunity. (2) Protecting cells, and after oncogenes are activated, changing the DNA structure of normal tissue cells, thereby causing tumorigenesis. EPA is an important component of a cell membrane structure and can play a role in protecting cells from being interfered and damaged by exogenous factors. (3) The study shows that EPA is helpful for esophageal cancer patients to keep fat-free weight after resection, weaken cachexia of tumor patients, reduce the expression of inflammatory cytokines, and regulate the activity of ATP-dependent ubiquitin-proteasome pathway, thereby changing nutritional status.
Glutamine is a free amino acid with the most abundant content in cells, can be synthesized by other amino acids in vivo, but under severe stress states such as diseases and malnutrition, the organism has increased glutamine demand, self synthesis cannot meet the demand, and exogenous supplementation is needed. Glutamine is a main energy substance of intestinal mucosa cells, lymphocytes and macrophages, and plays an important role in maintaining the normal structure and function of the intestinal mucosa, reducing the translocation of intestinal flora, enhancing immunity, relieving inflammation and the like. Under stress, when glutamine can not meet the demand of organisms, the intestinal mucosa barrier is damaged, the immunity is reduced, the flora imbalance, the tumor cells are diffused and transferred, and the like.
Therefore, there is a particular need for an immunonutrient supplement and method of making the same that addresses the above-identified problems.
Disclosure of Invention
The invention aims to provide an immune nutrient supplement and a preparation method thereof, aiming at the defects of the prior art, relieving the problems of malnutrition and the like caused by factors such as consumption and food intake obstruction of tumors, influence of the tumors on appetite, mental depression of patients and the like of malignant tumor patients in operative period and dyscrasia period, wherein the problems are accompanied by weight reduction, and the like, the postoperative support is well made, and the immune level of the patients is improved.
In order to achieve the above object, the technical problem solved by the present invention can be achieved by adopting the following technical solutions:
in a first aspect, the invention provides an immunonutrient supplement, which is characterized by being prepared from the following components in percentage by mass:
60-70% of L-arginine, 10-20% of EPA and 20-30% of glutamine.
In one embodiment of the invention, the immune nutrient supplement is prepared from the following components in percentage by mass:
66% of L-arginine, 12% of EPA and 22% of glutamine.
In a second aspect, the present invention provides a method of preparing an immunonutrient supplement, comprising the steps of:
(1) peeling the raw materials, and weighing after dedusting and sterilizing by a bale sterilizer;
(2) sequentially adding L-arginine, EPA and glutamine into a mixing tank of a mixing stirrer for fully mixing, discharging after uniformly mixing, continuously beating the bottom and the side surface of the mixing tank to ensure complete discharging, and sieving after discharging to obtain the product.
In one embodiment of the invention, the sterilization temperature is 20-40 degrees, and the sterilization time is not less than 60 seconds.
In one embodiment of the invention, the mixer-blender has a speed of 10-20 rpm and a mixing time of 10-20 min.
In one embodiment of the invention, the mixer-agitator is rotated at a speed of 5-10 rpm during discharge.
In one embodiment of the invention, the screened mesh is 60-70 mesh.
Compared with the prior art, the immune nutrient supplement and the preparation method thereof have the advantages that the formula is reasonable, and malnutrition, immunity reduction and damage to intestinal mucosa barrier caused by tumors are relieved. The occurrence of infectious diseases is reduced, the hospitalization time is shortened, and the life quality condition of the patient is enhanced; the design is reasonable, the production is easy, the control is convenient, and the purpose of the invention is realized.
The features of the present invention will be clearly understood by reference to the following detailed description of the preferred embodiments of the present invention.
Detailed Description
In order to make the technical means, the creation features, the achievement purposes and the effects of the invention easy to understand, the invention is further described with the specific embodiments.
Example 1
The immune nutrient supplement is prepared from the following components in percentage by mass:
66% of L-arginine, 12% of EPA and 22% of glutamine.
The preparation method of the immune nutrient supplement comprises the following steps:
(1) peeling the raw materials, performing dust removal and sterilization by a bale sterilizer, and weighing, wherein the sterilization temperature is 20 ℃, and the sterilization time is 60 seconds;
(2) sequentially adding L-arginine, EPA and glutamine into a mixing tank of a mixing stirrer for fully mixing, wherein the rotating speed of the mixing stirrer is 15 revolutions per minute, and the mixing time is 12 min; and (3) discharging after uniformly mixing, wherein during discharging, the rotating speed of the mixing stirrer is 5 revolutions per minute, the bottom and the side surface of the tank body of the mixing tank are continuously beaten to ensure complete discharging, and the product is obtained after 60-mesh sieving after discharging.
Example 2
The immune nutrient supplement is prepared from the following components in percentage by mass:
60% of L-arginine, 10% of EPA and 30% of glutamine.
The preparation method of the immune nutrient supplement comprises the following steps:
(1) peeling the raw materials, performing dust removal and sterilization by a bale sterilizer, and weighing, wherein the sterilization temperature is 40 ℃, and the sterilization time is 70 seconds;
(2) sequentially adding L-arginine, EPA and glutamine into a mixing tank of a mixing stirrer for fully mixing, wherein the rotating speed of the mixing stirrer is 10 revolutions per minute, and the mixing time is 20 min; and discharging after uniformly mixing, wherein during discharging, the rotating speed of the mixing stirrer is 10 revolutions per minute, the bottom and the side surface of the tank body of the mixing tank are continuously beaten to ensure complete discharging, and the product is obtained after the discharging is sieved by a 65-mesh sieve.
Example 3
The immune nutrient supplement is prepared from the following components in percentage by mass:
70% of L-arginine, 10% of EPA and 20% of glutamine.
The preparation method of the immune nutrient supplement comprises the following steps:
(1) peeling the raw materials, performing dust removal and sterilization by a bale sterilizer, and weighing, wherein the sterilization temperature is 30 ℃ and the sterilization time is 60 seconds;
(2) sequentially adding L-arginine, EPA and glutamine into a mixing tank of a mixing stirrer for fully mixing, wherein the rotating speed of the mixing stirrer is 20 revolutions per minute, and the mixing time is 10 min; and discharging after uniformly mixing, wherein during discharging, the rotating speed of the mixing stirrer is 6 revolutions per minute, the bottom and the side surface of the tank body of the mixing tank are continuously beaten to ensure complete discharging, and the product is obtained after the discharging is sieved by a 70-mesh sieve.
Example 4
The immune nutrient supplement is prepared from the following components in percentage by mass:
60% of L-arginine, 20% of EPA and 20% of glutamine.
The preparation method of the immune nutrient supplement comprises the following steps:
(1) peeling the raw materials, performing dust removal and sterilization by a bale sterilizer, and weighing, wherein the sterilization temperature is 25 ℃ and the sterilization time is 60 seconds;
(2) sequentially adding L-arginine, EPA and glutamine into a mixing tank of a mixing stirrer for fully mixing, wherein the rotating speed of the mixing stirrer is 15 revolutions per minute, and the mixing time is 12 min; and (3) discharging after uniformly mixing, wherein during discharging, the rotating speed of the mixing stirrer is 5 revolutions per minute, the bottom and the side surface of the tank body of the mixing tank are continuously beaten to ensure complete discharging, and the product is obtained after 60-mesh sieving after discharging.
Example 5
The immune nutrient supplement is prepared from the following components in percentage by mass:
61% of L-arginine, 13% of EPA and 26% of glutamine.
The preparation method of the immune nutrient comprises the following steps:
(1) peeling the raw materials, performing dust removal and sterilization by a bale sterilizer, and weighing, wherein the sterilization temperature is 25 ℃ and the sterilization time is 60 seconds;
(2) sequentially adding L-arginine, EPA and glutamine into a mixing tank of a mixing stirrer for fully mixing, wherein the rotating speed of the mixing stirrer is 15 revolutions per minute, and the mixing time is 12 min; and (3) discharging after uniformly mixing, wherein during discharging, the rotating speed of the mixing stirrer is 5 revolutions per minute, the bottom and the side surface of the tank body of the mixing tank are continuously beaten to ensure complete discharging, and the product is obtained after 60-mesh sieving after discharging.
Example 6
The immune nutrient supplement is prepared from the following components in percentage by mass:
67% of L-arginine, 12% of EPA and 21% of glutamine.
The preparation method of the immune nutrient supplement comprises the following steps:
(1) peeling the raw materials, performing dust removal and sterilization by a bale sterilizer, and weighing, wherein the sterilization temperature is 25 ℃ and the sterilization time is 60 seconds;
(2) sequentially adding L-arginine, EPA and glutamine into a mixing tank of a mixing stirrer for fully mixing, wherein the rotating speed of the mixing stirrer is 15 revolutions per minute, and the mixing time is 12 min; and (3) discharging after uniformly mixing, wherein during discharging, the rotating speed of the mixing stirrer is 5 revolutions per minute, the bottom and the side surface of the tank body of the mixing tank are continuously beaten to ensure complete discharging, and the product is obtained after 60-mesh sieving after discharging.
The foregoing shows and describes the general principles, essential features, and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are merely illustrative of the principles of the invention, but that various changes and modifications may be made without departing from the spirit and scope of the invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.

Claims (7)

1. The immune nutrient supplement is characterized by being prepared from the following components in percentage by mass:
60-70% of L-arginine, 10-20% of EPA and 20-30% of glutamine.
2. The immunonutrient supplement of claim 1, wherein the immunonutrient supplement is prepared from the following components in mass percent:
66% of L-arginine, EPA 12% and 22% of glutamine.
3. A method of preparing an immunonutrient supplement, comprising the steps of:
(1) peeling the raw materials, and weighing after dedusting and sterilizing by a bale sterilizer;
(2) sequentially adding L-arginine, EPA and glutamine into a mixing tank of a mixing stirrer for fully mixing, discharging after uniformly mixing, continuously beating the bottom and the side surface of the mixing tank to ensure complete discharging, and sieving after discharging to obtain the product.
4. The method of claim 3, wherein the temperature of sterilization is 20-40 degrees and the time of sterilization is not less than 60 seconds.
5. The method of claim 3, wherein the mixer/blender is operated at 10-20 rpm for 10-20 min.
6. The method of claim 3, wherein the mixer is operated at 5-10 rpm during discharge.
7. The method of claim 3, wherein the screened mesh is 60-70 mesh.
CN201910708365.2A 2019-08-01 2019-08-01 Immunity nutrient supplement and preparation method thereof Pending CN112294790A (en)

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Application Number Priority Date Filing Date Title
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Application Number Priority Date Filing Date Title
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CN112294790A true CN112294790A (en) 2021-02-02

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106715381A (en) * 2014-09-23 2017-05-24 约斯特化学公司 Fatty acid composition and method for fortifying nutritional products with fatty acids
CN107594506A (en) * 2016-09-20 2018-01-19 福建奥正投资发展有限公司 The combination of hydrophily lipid composite and water fluid, it is prepared and concocting method and application

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106715381A (en) * 2014-09-23 2017-05-24 约斯特化学公司 Fatty acid composition and method for fortifying nutritional products with fatty acids
CN107594506A (en) * 2016-09-20 2018-01-19 福建奥正投资发展有限公司 The combination of hydrophily lipid composite and water fluid, it is prepared and concocting method and application

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
于健春等: "免疫营养素(GLN，EPA，DHA)及化疗药物对胃癌细胞系生长干预的实验研究", 《中华医学会第十一届全国营养支持学术会议》 *
舒晓亮等: "L-精氨酸调控人胃癌细胞株SGC-7901凋亡及机制研究", 《第四届全国中西医结合营养学术会议论文资料汇编》 *

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Application publication date: 20210202