CN112220889A

CN112220889A - Traditional Chinese medicine for preventing and treating cardiovascular and cerebrovascular diseases and preparation method thereof

Info

Publication number: CN112220889A
Application number: CN201910563884.4A
Authority: CN
Inventors: 席圣林; 胡礼年
Original assignee: Individual
Current assignee: Individual
Priority date: 2019-06-26
Filing date: 2019-06-26
Publication date: 2021-01-15

Abstract

A Chinese medicine for preventing and treating cardiovascular and cerebrovascular diseases is prepared from Chinese-medicinal materials and their extracts through pulverizing, immersing, ultrasonic extracting, filtering, regulating pH value, concentrating, mixing and drying. The raw materials are extracted by ultrasonic waves, chemical reagents are not used in the preparation process, the natural active effective components of the raw materials are reserved, and the natural active effective components contain various natural flavone saponins, active biological enzymes, abundant amino acids, inorganic salts, various vitamins and trace elements, can quickly supplement qi and blood energy after being absorbed by a human body, regulate the life rhythm of visceral organ disorder, promote blood circulation to remove blood stasis, expel wind and remove phlegm, soften and erect stasis, efficiently and quickly decompose and dissolve lipid in blood, blood embolus and phlegm stasis, simultaneously expand, soften and repair blood vessels, recover the tension and elasticity of the blood vessels, improve the obstacle of cervical spondylosis to head blood supply and oxygen, reduce the blood viscosity, purify the blood vessels, clear and discharge harmful toxins and physiological garbage of the blood vessels, and really play a role in preventing and treating cardiovascular and cerebrovascular diseases.

Description

Traditional Chinese medicine for preventing and treating cardiovascular and cerebrovascular diseases and preparation method thereof

Technical Field

The invention relates to a traditional Chinese medicine and a preparation method thereof, in particular to a traditional Chinese medicine for preventing and treating cardiovascular and cerebrovascular diseases and a preparation method thereof.

Background

With the improvement of living standard and consumption ability of people, daily living habits, dietary structures and consumption concepts are changed: the excessive night life and sexual life cause the deficiency of essence and qi and blood; the incidence of cervical spondylosis is higher and higher by using the mobile phone for a long time with the head down; the consumption of meat, milk products and eggs leads people to ingest excessive fat, protein and cholesterol, so that the obese population is increased.

When waste cells, waste proteins, waste fibers, free calcium ions after metabolism of a human body are combined with excessive cholesterol and triglyceride in the human body, blood vessels are blocked, blood stasis is formed, internal heat is generated, body fluid is consumed by decoction, phlegm and blood stasis are formed, the phlegm and blood stasis are intertwined with each other, thrombus is generated, the blood vessels are obstructed, heart load is aggravated, myocardial strain, atherosclerosis and cardiovascular and cerebrovascular diseases are more and more commonly caused.

Western medicine subdivides human diseases into multiple disciplines and categories according to symptoms, and clinical medical treatment projects are also divided into multiple categories, and the clinical medical treatment means of treating diseases causes that when doctors encounter some diseases, multiple symptoms appear simultaneously or successively, and doctors are unfamiliar with the symptoms of other disciplines to cause syndrome differentiation errors and delay treatment time.

Disclosure of Invention

The invention aims to solve the problems in the background technology and provides a traditional Chinese medicine which is prepared from a plurality of compound compositions and can help, repair, dredge, clear, eliminate, regulate and supplement and regulate yin and yang, qi and blood, five internal organs and cervical vertebra of a human body so as to prevent and treat cardiovascular and cerebrovascular diseases and a preparation method thereof.

The technical scheme of the invention is as follows: a traditional Chinese medicine for preventing and treating cardiovascular and cerebrovascular diseases is characterized by comprising the following raw materials and raw material extracts in parts by weight:

the raw materials comprise: 20 to 35 portions of ginseng under forest, 20 to 45 portions of dwarf lilyturf tuber, 15 to 25 portions of Chinese magnoliavine fruit, 30 to 50 portions of salvia miltiorrhiza, 30 to 50 portions of rhynohophylla, 20 to 35 portions of achyranthes bidentata, 30 to 50 portions of white peony root, 30 to 50 portions of astragalus root, 20 to 35 portions of cassia twig, 30 to 50 portions of selfheal, 30 to 55 portions of radix rehmanniae recen, 20 to 35 portions of angelica, 20 to 35 portions of tall gastrodia tuber, 25 to 35 portions of tribulus terrestris, 30 to 50 portions of tuber fleeceflower root, 30 to 50 portions of cassia seed, 25 to 35 portions of epimedium herb, 15 to 25 portions of costustoot, 20 to 30 portions of frankincense and 25 to 35 portions of amber;

the raw material extracts comprise: 30 to 50 portions of puerarin, 20 to 30 portions of ligustrazine, 25 to 40 portions of panax notoginseng saponins, 25 to 35 portions of ginkgetin, 25 to 35 portions of gynostemma pentaphylla total glycoside, 30 to 50 portions of earthworm enzyme, 20 to 30 portions of hirudin and 20 to 30 portions of scorpion powder.

The preferable scheme of the invention is that the raw materials comprise the following components in parts by weight: 18 to 30 portions of ginseng under forest, 25 to 30 portions of dwarf lilyturf tuber, 17 to 20 portions of Chinese magnoliavine fruit, 25 to 45 portions of red sage root, 35 to 45 portions of rhynohophylla, 25 to 30 portions of twotooth achyranthes root, 35 to 45 portions of white peony root, 35 to 45 portions of membranous milkvetch root, 25 to 30 portions of cassia twig, 35 to 45 portions of common selfheal fruit-spike, 35 to 45 portions of raw rehmannia root, 25 to 30 portions of Chinese angelica, 25 to 30 portions of tall gastrodia tuber, 28 to 30 portions of tribulus terrestris, 35 to 45 portions of tuber fleeceflower root, 35 to 45 portions of cassia seed, 28 to 35 portions of epimedium herb, 18 to 20 portions of costustoot, 22 to 25 portions of frankincense and 26 to 30 portions of amber;

the raw material extract comprises the following components in parts by weight: 35 to 45 portions of puerarin, 22 to 25 portions of ligustrazine, 28 to 35 portions of panax notoginseng saponins, 28 to 30 portions of ginkgetin, 26 to 30 portions of gynostemma pentaphylla total glycoside, 35 to 45 portions of earthworm enzyme, 22 to 28 portions of hirudin and 22 to 28 portions of scorpion powder.

The preferable scheme of the invention is that the raw material extract further comprises: 20 to 60 portions of yellow wine, 20 to 60 portions of vinegar and 30 to 90 portions of honey.

A preparation method of the traditional Chinese medicine for preventing and treating cardiovascular and cerebrovascular diseases is characterized by comprising the following process steps:

1. crushing: weighing the raw materials according to the weight part ratio respectively, and crushing;

2. soaking: putting the crushed raw materials into a closed container, wherein the solid-liquid weight ratio is 1: 4, adding water according to the proportion, and soaking for 3-5 hours;

3. ultrasonic extraction: extracting the obtained raw material soak solution in an ultrasonic tank, heating the raw material soak solution from normal temperature to a temperature not higher than 40 ℃, and extracting for 50-60 minutes;

4. filtering and separating: filtering the obtained mixed solution to obtain filtrate and filter residue, centrifuging and filtering the filter residue to obtain secondary filtrate, and combining the two filtrates to obtain filtrate;

5. adjusting the pH value: adjusting the pH value of the filtrate to 7.5-7.7;

6. concentration: concentrating the filtrate to 75-80% of a concentrate;

7. mixing: adding the raw material extracts according to the weight part ratio, and uniformly mixing;

8. and (3) drying: drying the mixture to obtain the final product of effective components.

The further scheme is as follows: in the ultrasonic extraction step, the stirring speed in the ultrasonic tank was 1500 rpm, the ultrasonic power was 1500W, and the ultrasonic pause time was 90 seconds.

The further scheme is as follows: the drying step adopts a freeze-drying technology for drying, the freeze-drying is carried out at a low temperature below O ℃, the growth activity of microorganisms in the traditional Chinese medicinal materials can be kept, the loss of most volatile and aromatic substance components is avoided, the heat-sensitive substances are prevented from being denatured, inactivated or even oxidized, and the product is easy to crush or dissolve in water.

The further scheme is as follows: the obtained effective components can be processed into honeyed pill, capsule, tablet, powder, and granule by conventional method.

The further scheme is as follows: when processing the honeyed pill, the raw material extract may further comprise: 20 to 60 portions of yellow wine, 20 to 60 portions of vinegar and 30 to 90 portions of honey.

The invention adopts the technical scheme, adopts a plurality of traditional Chinese medicine raw materials and raw material extract compositions, adopts ultrasonic wave to extract the raw materials, does not use chemical reagents in the preparation process, keeps natural active effective components of the raw materials, contains a plurality of natural flavone saponins, active biological enzymes and rich amino acids, inorganic salts, various vitamins and trace elements, can quickly cultivate and supplement qi and blood energy after being absorbed by human body, regulate the life rhythm of organ disorder of internal organs, activate blood and remove stasis, expel wind and remove phlegm, soften and vertically disperse lumps, efficiently and quickly decompose and dissolve lipid, blood embolus and phlegm stasis in blood, simultaneously expand, soften, repair blood vessels, restore the tension and elasticity of the blood vessels, improve the obstacle of cervical spondylosis to head blood supply and oxygen, reduce the blood viscosity, purify the blood vessels, clear harmful toxins and physiological garbage of the blood vessels, really has the effect of preventing and treating cardiovascular and cerebrovascular diseases.

Detailed Description

Example 1

A preparation method of a traditional Chinese medicine for preventing and treating cardiovascular and cerebrovascular diseases comprises the following process steps:

1. crushing: weighing 20 to 35 parts of wild ginseng, 20 to 45 parts of dwarf lilyturf tuber, 15 to 25 parts of Chinese magnoliavine fruit, 30 to 50 parts of red-rooted salvia root, 30 to 50 parts of rhynohophylla, 20 to 35 parts of twotooth achyranthes root, 30 to 50 parts of white paeony root, 30 to 50 parts of membranous milkvetch root, 20 to 35 parts of cassia twig, 30 to 50 parts of common selfheal fruit-spike, 30 to 55 parts of raw rehmannia root, 20 to 35 parts of Chinese angelica, 20 to 35 parts of tall gastrodia tuber, 25 to 35 parts of tribulus terrestris, 30 to 50 parts of tuber fleeceflower root, 30 to 50 parts of cassia seed, 25 to 35 parts of epimedium herb, 15 to 25 parts of costustoot, 20 to 30 parts of frankincense and 25 to 35 parts of amber according to the weight part ratio, and crushing;

2. soaking: putting the crushed raw materials into a closed container, wherein the solid-liquid weight ratio is 1: 4, adding water according to the proportion, and soaking for 4 hours;

3. ultrasonic extraction: extracting the obtained raw material soak solution in an ultrasonic tank, heating the raw material soak solution from normal temperature to a temperature not higher than 40 ℃, wherein the extraction time is 55 minutes, the stirring speed in the ultrasonic tank is 1500 revolutions per minute, the ultrasonic power is 1500W, and the ultrasonic pause time is 90 seconds;

5. adjusting the pH value: adjusting the pH value of the filtrate to 7.6;

6. concentration: concentrating the filtrate to 77% concentrate;

7. mixing: adding 30-50 parts of puerarin, 20-30 parts of ligustrazine, 25-40 parts of panax notoginseng saponins, 25-35 parts of ginkgetin, 25-35 parts of gynostemma pentaphylla total glycosides, 30-50 parts of earthworm enzyme, 20-30 parts of hirudin and 20-30 parts of scorpion powder according to the weight part ratio, and uniformly mixing;

8. and (3) drying: freeze drying the mixture to obtain the final product of effective components.

Example 2

1. crushing: weighing 18 to 30 parts of wild ginseng, 25 to 30 parts of dwarf lilyturf tuber, 17 to 20 parts of Chinese magnoliavine fruit, 25 to 45 parts of red-rooted salvia root, 35 to 45 parts of rhynohophylla, 25 to 30 parts of twotooth achyranthes root, 35 to 45 parts of white paeony root, 35 to 45 parts of membranous milkvetch root, 25 to 30 parts of cassia twig, 35 to 45 parts of common selfheal fruit-spike, 35 to 45 parts of raw rehmannia root, 25 to 30 parts of Chinese angelica, 25 to 30 parts of tall gastrodia tuber, 28 to 30 parts of tribulus terrestris, 35 to 45 parts of tuber fleeceflower root, 35 to 45 parts of cassia seed, 28 to 35 parts of epimedium herb, 18 to 20 parts of costustoot, 22 to 25 parts of frankincense and 26 to 30 parts of amber according to the weight part ratio, and crushing;

5. adjusting the pH value: adjusting the pH value of the filtrate to 7.6;

6. concentration: concentrating the filtrate to 77% concentrate;

7. mixing: adding 35 to 45 parts of puerarin, 22 to 25 parts of ligustrazine, 28 to 35 parts of panax notoginseng saponins, 28 to 30 parts of ginkgetin, 26 to 30 parts of gynostemma pentaphylla total glycoside, 35 to 45 parts of earthworm enzyme, 22 to 28 parts of hirudin and 22 to 28 parts of scorpion powder according to the weight part ratio, and uniformly mixing;

The medicine used in the processing method has more accurate selected components and better using effect compared with the component in the embodiment 1.

Example 3

1. crushing: the raw materials are weighed according to the weight part ratio and comprise the following components in parts by weight: 24 parts of ginseng under forest, 28 parts of dwarf lilyturf tuber, 19 parts of Chinese magnoliavine fruit, 35 parts of salvia miltiorrhiza, 40 parts of rhynohophylla, 28 parts of achyranthes bidentata, 40 parts of white paeony root, 40 parts of astragalus root, 28 parts of cassia twig, 40 parts of selfheal, 40 parts of radix rehmanniae recen, 28 parts of angelica, 28 parts of tall gastrodia tuber, 29 parts of tribulus terrestris, 40 parts of tuber fleeceflower root, 40 parts of cassia seed, 32 parts of epimedium herb, 19 parts of costustoot, 24 parts of frankincense and 28;

5. adjusting the pH value: adjusting the pH value of the filtrate to 7.6;

6. concentration: concentrating the filtrate to 77% concentrate;

7. mixing: adding 40 parts of puerarin, 24 parts of ligustrazine, 32 parts of panax notoginseng saponins, 29 parts of ginkgetin, 28 parts of gynostemma pentaphylla total glycosides, 40 parts of earthworm enzyme, 25 parts of hirudin and 25 parts of scorpion powder according to the weight part ratio, and uniformly mixing;

The medicine proportion used in the processing method is more accurate in component selection, and the using effect is better than that of the components in the embodiment 1 and the embodiment 2.

Example 4

The effective component finished product obtained by the processing method can be processed into honeyed pills according to the existing medicine processing technology, and when the honeyed pill dosage form is processed, the raw material extracts also comprise: 40 parts of yellow wine, 40 parts of cool vinegar and 60 parts of honey.

Example 5

Treatment of case 1

Wu Yi, female, 36 years old, Heng Yang, Qidong county.

The face paralysis is close to the moon, the left face has the sense of walking ants after the face paralysis happens and the left face is worried about for a few days, when cooking, the user bends over to blow air into the matchwork stove by using the mouth, so that the left face is suddenly numb, then the mouth is inclined to the right, the left eye is dragged to be inclined and deformed, and the effects are not obvious after various treatment modes; the refined ointment prepared according to the traditional Chinese medicine proportion and the processing technology of the invention in the embodiment 3 is taken for a half month, and the face is restored after 8 days.

Treatment of case 2

Somebody in Cao, man, 70 years old, Heng Yang.

After 10 years of hemiplegia and aphasia, the right muscles of the body are seriously atrophied, the tongue body is askew left, the mouth angle salivates, the upper limbs are contracture, and the palm and fingers tightly gather the arm in front of the chest; the stiff and straight right leg, the left falling of the palm and toe, and the inability to bend and stretch with external force. The self-created five-element rehabilitation is applied to be matched with the oral administration of the refined ointment prepared according to the traditional Chinese medicine proportion and the processing technology of the embodiment 3 of the invention, the conditioning is performed for a half and a half, and the patient can recover the speaking function by suddenly making a sound; after conditioning for 3 months, the right half body muscle of the patient recovers to be normal, the right leg can be freely stretched and bent, the walking stick is thrown away to open the walking path, the right palm finger can be freely held, the cover of the mineral water bottle can be unscrewed, and the life self-care is basically recovered.

Treatment of case 3

Somebody yellow, woman, 53 years old, Heng nan county.

Shoulder pain and soreness of waist can be caused for many years, and the patient can self-complain: the patient is intolerant to cold from the beginning, the limbs are not warm in winter, the hands and the feet are cold, and the patient self-complains when seeing a doctor: the blood pressure is low all the time, dizziness often occur, the food consumption is small, the excrement is taken for 2-3 days, but the dry excrement is not generated; pulse taking: the deep and thready pulse of both hands, the rapid and slow pulse, sometimes with the appearance of knotted pulse. The diagnosis is as follows: deficiency of heart yang, constitution with yin cold, qi deficiency and blood weakness, poor appetite of stomach and intestine, and blood deficiency and malnutrition of channels, which can cause long-term soreness and pain of shoulder and waist and dizziness. The refined ointment prepared according to the traditional Chinese medicine proportion and the processing technology of the invention in the embodiment 3 is continuously taken for 3 months, all symptoms are eliminated, and the ointment is not afraid of cold in winter.

Treatment of case 4

Wangzhi, male, 68 years old, Zhuhai City.

The hypertension patient has a history of hypertension of nearly 30 years, and is maintained by lowering blood pressure by western medicines all the time; in recent years, the blood pressure is increased, the control is difficult, the medicine amount for reducing the blood pressure is doubled each time, a frequency spectrograph is purchased, the frequency spectrum room assists in reducing the blood pressure, the systolic pressure is promoted to break through 200, the diastolic pressure breaks through 120, and the traditional Chinese medicine conditioning is searched for by disconcerting. In the clinic, the physician needs to examine the excessive and forceful pulses of the guan pulse, which are typical of the excessive hypertension due to kidney-water deficiency and hyperactivity of liver-yang. 7 doses of the medicine are applied according to symptoms, the blood pressure of the medicine is controlled to be moderate hypertension, and then refined ointment is prepared according to the traditional Chinese medicine proportion and the processing technology of the embodiment 3 of the invention to enable the medicine to be continuously taken for 2 months, so that the blood pressure of the medicine is recovered to be normal.

Treatment of case 5

Li A certain, female, age 46, people in Zhuhai City.

The patient suffers from left migraine for several months and has a history of mild hypertension. The left-hand middle finger, ring finger and little finger are often numbed and swollen, and the left scapular tendon is stiff wood. It is characterized by that it is a cervical vertebra organic lesion, and can press cervical nerve, and can result in the deficiency of blood supply of left head, local angiosclerosis and atrophy, and can make the new and old metabolic physiological wastes of head block in the narrow place of blood vessel to form obstruction, and can press nerve to cause migraine and finger numbness. The refined ointment is prepared according to the traditional Chinese medicine proportion and the processing technology of the invention in the embodiment 3, and the symptoms are completely eliminated after the refined ointment is continuously taken for one month.

Claims

1. A traditional Chinese medicine for preventing and treating cardiovascular and cerebrovascular diseases is characterized by comprising the following raw materials and raw material extracts in parts by weight:

2. The traditional Chinese medicine for preventing and treating cardiovascular and cerebrovascular diseases as claimed in claim 1, wherein the raw materials comprise the following components in parts by weight: 18 to 30 portions of ginseng under forest, 25 to 30 portions of dwarf lilyturf tuber, 17 to 20 portions of Chinese magnoliavine fruit, 25 to 45 portions of red sage root, 35 to 45 portions of rhynohophylla, 25 to 30 portions of twotooth achyranthes root, 35 to 45 portions of white peony root, 35 to 45 portions of membranous milkvetch root, 25 to 30 portions of cassia twig, 35 to 45 portions of common selfheal fruit-spike, 35 to 45 portions of raw rehmannia root, 25 to 30 portions of Chinese angelica, 25 to 30 portions of tall gastrodia tuber, 28 to 30 portions of tribulus terrestris, 35 to 45 portions of tuber fleeceflower root, 35 to 45 portions of cassia seed, 28 to 35 portions of epimedium herb, 18 to 20 portions of costustoot, 22 to 25 portions of frankincense and 26 to 30 portions of amber;

3. The traditional Chinese medicine for preventing and treating cardiovascular and cerebrovascular diseases according to claim 1 or 2, characterized in that the raw material extract further comprises: 20 to 60 portions of yellow wine, 20 to 60 portions of vinegar and 30 to 90 portions of honey.

4. A method for preparing the traditional Chinese medicine for preventing and treating cardiovascular and cerebrovascular diseases as claimed in claims 1-3, which is characterized by comprising the following steps:

(1) and crushing: weighing the raw materials according to the weight part ratio respectively, and crushing;

(2) and soaking: putting the crushed raw materials into a closed container, wherein the solid-liquid weight ratio is 1: 4, adding water according to the proportion, and soaking for 3-5 hours;

(3) and ultrasonic extraction: extracting the obtained raw material soak solution in an ultrasonic tank, heating the raw material soak solution from normal temperature to a temperature not higher than 40 ℃, and extracting for 50-60 minutes;

(4) and filtering and separating: filtering the obtained mixed solution to obtain filtrate and filter residue, centrifuging and filtering the filter residue to obtain secondary filtrate, and combining the two filtrates to obtain filtrate;

(5) and adjusting the pH value: adjusting the pH value of the filtrate to 7.5-7.7;

(6) and concentrating: concentrating the filtrate to 75-80% of a concentrate;

(7) and mixing: adding the raw material extracts according to the weight part ratio, and uniformly mixing;

(8) and (3) drying: drying the mixture to obtain the final product of effective components.

5. The method for preparing a Chinese medicinal composition for preventing and treating cardiovascular and cerebrovascular diseases according to claim 4, wherein in the ultrasonic extraction step, the stirring speed in the ultrasonic tank is 1500 rpm, the ultrasonic power is 1500W, and the ultrasonic pause time is 90 seconds.

6. The preparation method of a Chinese medicine for preventing and treating cardiovascular and cerebrovascular diseases according to claim 4 or 5, characterized in that the drying step is drying by freeze-drying technique.

7. The preparation method of a traditional Chinese medicine for preventing and treating cardiovascular and cerebrovascular diseases as claimed in claim 4 or 5, wherein the finished product of the effective ingredients can be processed into honeyed pills, capsules, tablets, powders and granules.

8. The method for preparing a Chinese medicinal composition for preventing and treating cardiovascular and cerebrovascular diseases according to claim 6, wherein the effective components are processed into honeyed pills, capsules, tablets, powders, and granules.

9. The method for preparing a Chinese medicinal composition for preventing and treating cardiovascular and cerebrovascular diseases according to claim 7, wherein the step of mixing comprises the steps of: 20 to 60 portions of yellow wine, 20 to 60 portions of vinegar and 30 to 90 portions of honey.

10. The method for preparing a Chinese medicinal composition for preventing and treating cardiovascular and cerebrovascular diseases according to claim 8, wherein the step of mixing comprises the steps of: 20 to 60 portions of yellow wine, 20 to 60 portions of vinegar and 30 to 90 portions of honey.