CN112208175A - 一种药用复合膜及其制备方法 - Google Patents
一种药用复合膜及其制备方法 Download PDFInfo
- Publication number
- CN112208175A CN112208175A CN202010994414.6A CN202010994414A CN112208175A CN 112208175 A CN112208175 A CN 112208175A CN 202010994414 A CN202010994414 A CN 202010994414A CN 112208175 A CN112208175 A CN 112208175A
- Authority
- CN
- China
- Prior art keywords
- composite film
- polyethylene
- polypropylene
- outer layer
- inner layer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002131 composite material Substances 0.000 title claims abstract description 53
- 239000012528 membrane Substances 0.000 title claims abstract description 23
- 238000002360 preparation method Methods 0.000 title description 7
- 239000002994 raw material Substances 0.000 claims abstract description 45
- 239000004698 Polyethylene Substances 0.000 claims abstract description 26
- 229920000573 polyethylene Polymers 0.000 claims abstract description 26
- 239000004952 Polyamide Substances 0.000 claims abstract description 20
- 229920002647 polyamide Polymers 0.000 claims abstract description 20
- 229920001577 copolymer Polymers 0.000 claims abstract description 13
- 229920001684 low density polyethylene Polymers 0.000 claims abstract description 13
- 239000004702 low-density polyethylene Substances 0.000 claims abstract description 13
- 229920001179 medium density polyethylene Polymers 0.000 claims abstract description 13
- 239000004701 medium-density polyethylene Substances 0.000 claims abstract description 13
- 239000002216 antistatic agent Substances 0.000 claims abstract description 9
- 238000001816 cooling Methods 0.000 claims description 20
- -1 polypropylene Polymers 0.000 claims description 15
- 230000003068 static effect Effects 0.000 claims description 14
- 230000005611 electricity Effects 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 9
- 238000000071 blow moulding Methods 0.000 claims description 8
- 238000005096 rolling process Methods 0.000 claims description 8
- 239000004743 Polypropylene Substances 0.000 claims description 7
- 229920001155 polypropylene Polymers 0.000 claims description 7
- 230000008569 process Effects 0.000 claims description 6
- AQFWNELGMODZGC-UHFFFAOYSA-N o-ethylhydroxylamine Chemical group CCON AQFWNELGMODZGC-UHFFFAOYSA-N 0.000 claims description 5
- 229920000915 polyvinyl chloride Polymers 0.000 claims description 5
- 239000004800 polyvinyl chloride Substances 0.000 claims description 5
- FATBGEAMYMYZAF-KTKRTIGZSA-N oleamide Chemical compound CCCCCCCC\C=C/CCCCCCCC(N)=O FATBGEAMYMYZAF-KTKRTIGZSA-N 0.000 claims description 4
- FATBGEAMYMYZAF-UHFFFAOYSA-N oleicacidamide-heptaglycolether Natural products CCCCCCCCC=CCCCCCCCC(N)=O FATBGEAMYMYZAF-UHFFFAOYSA-N 0.000 claims description 4
- 238000009966 trimming Methods 0.000 claims description 4
- 238000002844 melting Methods 0.000 claims description 3
- 230000008018 melting Effects 0.000 claims description 3
- 238000007493 shaping process Methods 0.000 claims description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims description 2
- 238000004806 packaging method and process Methods 0.000 abstract description 8
- 239000004014 plasticizer Substances 0.000 abstract description 6
- 230000004888 barrier function Effects 0.000 abstract description 4
- 230000009286 beneficial effect Effects 0.000 abstract description 3
- 229940126601 medicinal product Drugs 0.000 abstract description 2
- 238000005520 cutting process Methods 0.000 description 10
- 230000003749 cleanliness Effects 0.000 description 6
- 238000013329 compounding Methods 0.000 description 5
- 239000000498 cooling water Substances 0.000 description 5
- 238000005336 cracking Methods 0.000 description 5
- 238000001125 extrusion Methods 0.000 description 5
- 238000005187 foaming Methods 0.000 description 5
- 229920003023 plastic Polymers 0.000 description 5
- 239000004033 plastic Substances 0.000 description 5
- 239000003814 drug Substances 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 238000007789 sealing Methods 0.000 description 4
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 3
- 230000006978 adaptation Effects 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000004803 Di-2ethylhexylphthalate Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- BJQHLKABXJIVAM-UHFFFAOYSA-N bis(2-ethylhexyl) phthalate Chemical compound CCCCC(CC)COC(=O)C1=CC=CC=C1C(=O)OCC(CC)CCCC BJQHLKABXJIVAM-UHFFFAOYSA-N 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000010101 extrusion blow moulding Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 229940127554 medical product Drugs 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/06—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material
- B32B27/08—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
- B29D7/00—Producing flat articles, e.g. films or sheets
- B29D7/01—Films or sheets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/18—Layered products comprising a layer of synthetic resin characterised by the use of special additives
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/32—Layered products comprising a layer of synthetic resin comprising polyolefins
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/34—Layered products comprising a layer of synthetic resin comprising polyamides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D65/00—Wrappers or flexible covers; Packaging materials of special type or form
- B65D65/38—Packaging materials of special type or form
- B65D65/40—Applications of laminates for particular packaging purposes
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J5/00—Manufacture of articles or shaped materials containing macromolecular substances
- C08J5/18—Manufacture of films or sheets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2250/00—Layers arrangement
- B32B2250/24—All layers being polymeric
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2270/00—Resin or rubber layer containing a blend of at least two different polymers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/20—Properties of the layers or laminate having particular electrical or magnetic properties, e.g. piezoelectric
- B32B2307/21—Anti-static
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/30—Properties of the layers or laminate having particular thermal properties
- B32B2307/31—Heat sealable
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/50—Properties of the layers or laminate having particular mechanical properties
- B32B2307/54—Yield strength; Tensile strength
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/70—Other properties
- B32B2307/724—Permeability to gases, adsorption
- B32B2307/7242—Non-permeable
- B32B2307/7246—Water vapor barrier
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2553/00—Packaging equipment or accessories not otherwise provided for
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2323/00—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers
- C08J2323/02—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers not modified by chemical after treatment
- C08J2323/04—Homopolymers or copolymers of ethene
- C08J2323/06—Polyethene
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2323/00—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers
- C08J2323/02—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers not modified by chemical after treatment
- C08J2323/10—Homopolymers or copolymers of propene
- C08J2323/14—Copolymers of propene
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2423/00—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers
- C08J2423/02—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers not modified by chemical after treatment
- C08J2423/16—Ethene-propene or ethene-propene-diene copolymers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K2201/00—Specific properties of additives
- C08K2201/017—Additives being an antistatic agent
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/16—Nitrogen-containing compounds
- C08K5/17—Amines; Quaternary ammonium compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/16—Nitrogen-containing compounds
- C08K5/20—Carboxylic acid amides
Landscapes
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Mechanical Engineering (AREA)
- Manufacturing & Machinery (AREA)
- Materials Engineering (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Laminated Bodies (AREA)
- Shaping By String And By Release Of Stress In Plastics And The Like (AREA)
Abstract
本发明公开一种药用复合膜,所述药用复合膜包括:复合膜内层、中层和外层;所述内层原料包括:68wt%~77wt%的低密度聚乙烯、12wt%~21wt%的中密度聚乙烯与2wt%~20wt%乙丙共聚物;所述中层原料为聚酰胺或改性聚酰胺;所述外层原料包括:95~99wt%的聚丙烯‑聚乙烯共聚物和1wt%~5wt%的抗静电剂。所述药用复合膜无增塑剂使用,力学性好,阻隔性强,热封性好,抗静电能力好,利于用于药用产品包装和运输。
Description
技术领域
本发明涉及工业包装领域领域,具体涉及一种药用复合膜及其制备方法。
背景技术
国内外输液包装有玻璃瓶,塑料瓶和塑料袋三种型式。塑料袋输液由于其具有便于工作运输,仓储体积小,在使用过程不需要向药液中引入空气,避免空气中的灰尘,微生物污染药液等优点,正逐渐取代玻璃瓶和塑料瓶。目前常用的PVC塑料材料中由于增塑剂等助剂导致药液被二次污染,给临床用药带来潜在安全隐患。特别是PVC膜生产过程中加入的增塑剂(DEHP)是一种有害物质,严重危害人体健康,因而国家药品监督管理局已明令限制使用。
发明内容
有鉴于此,本发明提供了一种药用复合膜及其制备方法,所述药用复合膜无增塑剂使用,力学性好,阻隔性强,热封性好,抗静电能力好,利于用于药用产品包装和运输。
为解决以上技术问题,本发明提供的技术方案是提供一种药用复合膜,所述药用复合膜包括:复合膜内层、中层和外层;所述内层原料包括:68wt%~77wt%的低密度聚乙烯、12wt%~21wt%的中密度聚乙烯与2wt%~20wt%乙丙共聚物;所述中层原料为聚酰胺或改性聚酰胺;所述外层原料包括:95~99wt%的聚丙烯-聚乙烯共聚物和1wt%~5wt%的抗静电剂。
优选的,所述内层原料包括:70wt%~75wt%的低密度聚乙烯、15wt%~20wt%的中密度聚乙烯与5wt%~15wt%乙丙共聚物。
优选的,所述内层原料包括:72wt%的低密度聚乙烯、18wt%的中密度聚乙烯与10wt%乙丙共聚物。
优选的,所述外层原料包括:97.8~98.2wt%聚丙烯-聚乙烯共聚物和1.8wt%~2.2wt%的抗静电剂。
优选的,所述外层原料包括:98wt%的聚丙烯-聚乙烯共聚物和2wt%的抗静电剂。
优选的,所述聚丙烯-聚乙烯共聚物中聚丙烯的含量为20~30wt%;聚乙烯的含量为70~80wt%
优选的,所述改性聚酰胺为聚氯乙烯改性的聚酰胺或丙烯酸酯改性的聚酰胺。
优选的,所述中层原料为聚酰胺。
优选的,所述抗静电剂为乙氧基胺或单甘脂油酸酰胺。
优选的,内层的厚度为50~60μm;中层的厚度为20~30μm;外层的厚度为30~40μm。
本发明还提供了一种上述的药用复合膜的制备方法,包括:将所述内层原料、所述中层原料和所述外层原料熔融共挤出吹塑、拉伸、冷却定型、分切、除静电后收卷得到所述药用复合膜。
优选的,所述熔融温度为160℃~350℃
优选的,所述冷却温度为10~12℃。
优选的,分切过程具体为经第一次牵引切边,展平轴展平后,第二次牵引切边。
优选的,所述吹塑过程采用洁净度物100级的空气。
本申请药用复合膜内层原料采用低密度聚乙烯、中密度聚乙烯和乙丙共聚物,不含有可析出的小分子物质,使药用复合膜的表面张力值能保持长久,同时也有利于复合剥离力的提高,扩大热封温度范围,保证生物相容性,对药液没有影响;乙丙共聚物加入起到乳化剂的作用,促使低密度聚乙烯和中密度聚乙烯的分散相微细化、均匀分散,提高粘合强度,进而提高了药用复合膜的横向、纵向拉伸强度。
本申请药用复合膜中间层采用聚酰胺或改性聚酰胺,起到阻隔增强的作用。
本申请药用复合膜外层原料聚丙烯-聚乙烯共聚体具有优良的抗污染性,能很好地解决粉剂包装热封问题。并且热封温度有明显的下降,更适合于快速包装,同时加入抗静电剂增加外层抗静电能力,增加运输存储安全性。
本申请制备除静电后收卷得到复合膜
本申请与现有技术相比,其详细说明如下:
本申请提供的药用复合膜优选内层、中层和外层原料,无增塑剂使用,使药用复合膜,力学性好,阻隔性强,热封性好,抗静电能力好,利于用于药用产品包装和运输;
本申请提供的制备方法采用共挤出吹塑、拉伸、冷却定型、分切、除静电后收卷,工艺简单,制备的药用复合膜机构稳定性强、平整,便于贮存运输。
具体实施方式
为了使本领域的技术人员更好地理解本发明的技术方案,下面结合具体实施例对本发明作进一步的详细说明。
实施例1
按如下方法制备药用复合膜:
药用复合膜内层原料包括:68wt%的低密度聚乙烯、12wt%的中密度聚乙烯与20wt%乙丙共聚物;中层原料为聚酰胺;外层原料包括:95wt%的聚丙烯-聚乙烯共聚物和5wt%的乙氧基胺,所述聚丙烯-聚乙烯共聚物中聚丙烯的含量为20wt%;聚乙烯的含量为80wt%。
将所述内层原料、所述中层原料和所述外层原料160℃~350℃熔融共挤出,洁净度物100级的空气吹塑,拉伸,冷却温度为10~12℃冷却水冷却定型,经第一次牵引切边,展平轴展平后,第二次牵引切边,除静电器除静电后收卷得到所述药用复合膜。
得到的所述药用复合膜内层的厚度为50~60μm;中层的厚度为20~30μm;外层的厚度为30~40μm,层次分明、美观、复合紧密、不起泡、不破裂。
实施例2
按如下方法制备药用复合膜:
药用复合膜内层原料包括:70wt%的低密度聚乙烯、15wt%的中密度聚乙烯与15wt%乙丙共聚物;中层原料为聚氯乙烯改性的聚酰胺;外层原料包括:97.8wt%的聚丙烯-聚乙烯共聚物和2.2wt%的乙氧基胺,所述聚丙烯-聚乙烯共聚物中聚丙烯的含量为20wt%;聚乙烯的含量为80wt%。
将所述内层原料、所述中层原料和所述外层原料160℃~350℃熔融共挤出,洁净度物100级的空气吹塑,拉伸,冷却温度为10~12℃冷却水冷却定型,经第一次牵引切边,展平轴展平后,第二次牵引切边,除静电器除静电后收卷得到所述药用复合膜。
得到的所述药用复合膜内层的厚度为50~60μm;中层的厚度为20~30μm;外层的厚度为30~40μm,层次分明、美观、复合紧密、不起泡、不破裂。
实施例3
按如下方法制备药用复合膜:
药用复合膜内层原料包括:72wt%的低密度聚乙烯、18wt%的中密度聚乙烯与10wt%乙丙共聚物;中层原料为丙烯酸酯改性的聚酰胺;外层原料包括:98wt%的聚丙烯-聚乙烯共聚物和2wt%的乙氧基胺,所述聚丙烯-聚乙烯共聚物中聚丙烯的含量为25wt%;聚乙烯的含量为75wt%。
将所述内层原料、所述中层原料和所述外层原料160℃~350℃熔融共挤出,洁净度物100级的空气吹塑,拉伸,冷却温度为10~12℃冷却水冷却定型,经第一次牵引切边,展平轴展平后,第二次牵引切边,除静电器除静电后收卷得到所述药用复合膜。
得到的所述药用复合膜内层的厚度为50~60μm;中层的厚度为20~30μm;外层的厚度为30~40μm,层次分明、美观、复合紧密、不起泡、不破裂。
实施例4
按如下方法制备药用复合膜:
药用复合膜内层原料包括:75wt%的低密度聚乙烯、20wt%的中密度聚乙烯与5wt%乙丙共聚物;中层原料为聚酰胺;外层原料包括:98.2wt%的聚丙烯-聚乙烯共聚物和1.8wt%的单甘脂油酸酰胺,所述聚丙烯-聚乙烯共聚物中聚丙烯的含量为30wt%;聚乙烯的含量为70wt%。
将所述内层原料、所述中层原料和所述外层原料160℃~350℃熔融共挤出,洁净度物100级的空气吹塑,拉伸,冷却温度为10~12℃冷却水冷却定型,经第一次牵引切边,展平轴展平后,第二次牵引切边,除静电器除静电后收卷得到所述药用复合膜。
得到的所述药用复合膜内层的厚度为50~60μm;中层的厚度为20~30μm;外层的厚度为30~40μm,层次分明、美观、复合紧密、不起泡、不破裂。
实施例5
按如下方法制备药用复合膜:
药用复合膜内层原料包括:77wt%的低密度聚乙烯、21wt%的中密度聚乙烯与2wt%乙丙共聚物;中层原料为聚酰胺;外层原料包括:99wt%的聚丙烯-聚乙烯共聚物和1wt%的单甘脂油酸酰胺,所述聚丙烯-聚乙烯共聚物中聚丙烯的含量为30wt%;聚乙烯的含量为70wt%。
将所述内层原料、所述中层原料和所述外层原料160℃~350℃熔融共挤出,洁净度物100级的空气吹塑,拉伸,冷却温度为10~12℃冷却水冷却定型,经第一次牵引切边,展平轴展平后,第二次牵引切边,除静电器除静电后收卷得到所述药用复合膜。
得到的所述药用复合膜内层的厚度为50~60μm;中层的厚度为20~30μm;外层的厚度为30~40μm,层次分明、美观、复合紧密、不起泡、不破裂。
实施例6
将实施例1~5制得的药用复合膜编号A~E,测试其性能,结果见表1。
表1
由表1可知,抗拉伸强度、抗撕裂性、抗压性力学性能较好,水蒸汽透过量和氧气透过量低,阻隔性好,热封性能好,表面抗静电能力好能够满足药用包装的需求。
以上仅是本发明的优选实施方式,应当指出的是,上述优选实施方式不应视为对本发明的限制,本发明的保护范围应当以权利要求所限定的范围为准。对于本技术领域的普通技术人员来说,在不脱离本发明的精神和范围内,还可以做出若干改进和润饰,这些改进和润饰也应视为本发明的保护范围。
Claims (10)
1.一种药用复合膜,其特征在于,所述药用复合膜包括:复合膜内层、中层和外层;所述内层原料包括:68wt%~77wt%的低密度聚乙烯、12wt%~21wt%的中密度聚乙烯与2wt%~20wt%乙丙共聚物;所述中层原料为聚酰胺或改性聚酰胺;所述外层原料包括:95~99wt%的聚丙烯-聚乙烯共聚物和1wt%~5wt%的抗静电剂。
2.根据权利要求1的药用复合膜,其特征在于,所述内层原料包括:70wt%~75wt%的低密度聚乙烯、15wt%~20wt%的中密度聚乙烯与5wt%~15wt%乙丙共聚物。
3.根据权利要求1的药用复合膜,其特征在于,所述外层原料包括:97.8~98.2wt%的聚丙烯-聚乙烯共聚物和1.8wt%~2.2wt%的抗静电剂。
4.根据权利要求1的药用复合膜,其特征在于,所述聚丙烯-聚乙烯共聚物中聚丙烯的含量为20~30wt%;聚乙烯的含量为70~80wt%。
5.根据权利要求1的药用复合膜,其特征在于,所述改性聚酰胺为聚氯乙烯改性的聚酰胺或丙烯酸酯改性的聚酰胺。
6.根据权利要求1的药用复合膜,其特征在于,所述抗静电剂为乙氧基胺或单甘脂油酸酰胺。
7.根据权利要求1的药用复合膜,其特征在于,内层的厚度为50~60μm;中层的厚度为20~30μm;外层的厚度为30~40μm。
8.一种权利要求1至6任一项所述的药用复合膜的制备方法,其特征在于,包括:将所述内层原料、所述中层原料和所述外层原料熔融共挤出吹塑、拉伸、冷却定型、分切、除静电后收卷得到所述药用复合膜。
9.根据权利要求7的制备方法,其特征在于,所述冷却温度为10~12℃。
10.根据权利要求7的制备方法,其特征在于,分切过程具体为经第一次牵引切边,展平轴展平后,第二次牵引切边。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010994414.6A CN112208175A (zh) | 2020-09-21 | 2020-09-21 | 一种药用复合膜及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010994414.6A CN112208175A (zh) | 2020-09-21 | 2020-09-21 | 一种药用复合膜及其制备方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN112208175A true CN112208175A (zh) | 2021-01-12 |
Family
ID=74049709
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202010994414.6A Pending CN112208175A (zh) | 2020-09-21 | 2020-09-21 | 一种药用复合膜及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN112208175A (zh) |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102717573A (zh) * | 2012-07-03 | 2012-10-10 | 浙江金石包装有限公司 | 一种改性聚乙烯薄膜及其制成的复合膜 |
CN103158313A (zh) * | 2013-03-14 | 2013-06-19 | 安徽省宁国双津(集团)实业有限公司 | 一种五层医用液体药剂包装薄膜及其制造方法 |
CN103171192A (zh) * | 2011-12-20 | 2013-06-26 | 常州市华健药用包装材料有限公司 | 一种药用复合膜及其制备方法 |
CN104385770A (zh) * | 2014-12-05 | 2015-03-04 | 四川科伦药业股份有限公司 | 一种基于药用包装的三层复合膜的剥离方法 |
CN207274061U (zh) * | 2017-05-08 | 2018-04-27 | 杭州巨杰包装科技有限公司 | 一种高强度五层共挤复合膜 |
-
2020
- 2020-09-21 CN CN202010994414.6A patent/CN112208175A/zh active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103171192A (zh) * | 2011-12-20 | 2013-06-26 | 常州市华健药用包装材料有限公司 | 一种药用复合膜及其制备方法 |
CN102717573A (zh) * | 2012-07-03 | 2012-10-10 | 浙江金石包装有限公司 | 一种改性聚乙烯薄膜及其制成的复合膜 |
CN103158313A (zh) * | 2013-03-14 | 2013-06-19 | 安徽省宁国双津(集团)实业有限公司 | 一种五层医用液体药剂包装薄膜及其制造方法 |
CN104385770A (zh) * | 2014-12-05 | 2015-03-04 | 四川科伦药业股份有限公司 | 一种基于药用包装的三层复合膜的剥离方法 |
CN207274061U (zh) * | 2017-05-08 | 2018-04-27 | 杭州巨杰包装科技有限公司 | 一种高强度五层共挤复合膜 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US7569262B2 (en) | Flexible monolayer elastomer films and bag for medical use | |
EP0114964B1 (en) | Polymer blend and flexible container made thereof | |
EP1210389B1 (en) | Autoclavable non-adherent, heat sealable polymer blends for fabricating monolayer and multiple layered films | |
US4528220A (en) | Plastic bags for medical solutions and blood | |
EP1689813B1 (en) | High impact strength film and non-pvc containing container and pouch and overpouch | |
AU2001245850A1 (en) | Containers and peelable seal containers of new non-PVC material | |
CA2756029A1 (en) | Non-pvc films with tough core layer | |
JPH09262948A (ja) | 樹脂積層体およびその用途 | |
JP6264092B2 (ja) | 易引裂性多層フィルム及び包装材 | |
CN112208175A (zh) | 一种药用复合膜及其制备方法 | |
WO2022107576A1 (ja) | ポリオレフィン系樹脂フィルム、及びそれを用いた積層体 | |
JP6675609B2 (ja) | 菌床栽培袋用フィルム及び菌床栽培袋 | |
CN108340647B (zh) | 一种液液多室袋用五层共挤输液膜及其制备方法 | |
JP2647994B2 (ja) | 医薬品容器用ゴム栓 | |
CN108382035A (zh) | 一种五层共挤输液用膜及其制备工艺 | |
EP0965443B1 (en) | Polymer composite tubular film with barrier structures | |
JP6085165B2 (ja) | 容器の開口部を封止するためのキャップ用のパッキン、ならびにそれを具備する蓋体および密閉容器 | |
JP3625497B2 (ja) | 医療容器用基材 | |
JP3973703B2 (ja) | 医療用複室容器 | |
CN116674273A (zh) | 一种多层膜及其制备方法 | |
DE60131515T2 (de) | Autoklavierbare, nicht klebende, heissiegelbare polymermischungen zur herstellung von folien aus einer oder mehreren schichten | |
JPH0531156A (ja) | 医薬液剤入り容器 | |
JPH0930566A (ja) | 凍結保存用容器の基材 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20210112 |