CN1121879C

CN1121879C - Apparatus for supporting life

Info

Publication number: CN1121879C
Application number: CN 97107699
Authority: CN
Inventors: 彭罗民
Original assignee: Individual
Current assignee: Individual
Priority date: 1997-09-30
Filing date: 1997-09-30
Publication date: 2003-09-24
Anticipated expiration: 2017-09-30
Also published as: CN1190598A

Abstract

The present invention is used for curing renal failure, liver failure, multiple organ failure, drug poisoning and toxic substance poisoning (organophosphorus pesticide, zinc phosphide, raticide, heroinismus, and addiction). The present invention is a multifunctional life supporting apparatus composed of a blood purification system, a bioartificial liver extracorporeal blood circulation system, a plasma circulation system, a plasma exchange system, a biologic artificial kidney extracorporeal blood circulation system and a blood plasma partitioning cycle displacement system. The present invention is a comprehensive system high and new technology scheme and a device. The present invention has the advantages of concise design, wide manufacturing material source, low price and simple manufacturing technology. The product has wide application prospect and is suitable for different levels of hospitals to use.

Description

Apparatus for supporting life

The present invention relates to a kind of armarium, particularly a kind of apparatus for supporting life.The present invention is fit to medical institutions at different levels and is used to give treatment to acute hepatic failure, acute and chronic renal failure, each phase uremia, the multiple organ failure, MOF merges liver, renal failure, drug intoxication (sedative hypnotics, psychosis, rat poison, organophosphorus pesticide etc.), alcoholism, heroin, morphinism, heroin addiction person etc.

At present, the mortality rate of hepatitis gravis is still up to 80～90%, and the liver failure that the conventional medicine therapy causes hepatitis gravis seems powerless.Up to now, still do not have a kind of comparatively perfect artificial liver device, more do not have the complete compound life support unit of the Liver and kidney with biological function.Still there are many shortcomings in existing conventional artificial kidney machine: 1. cost an arm and a leg; 2. the volume heaviness can not be moved the sick bed side at any time to according to patient's the state of an illness and give treatment to; 3. rely on water source, power supply; 4. the disposable use of dialysis solution promptly dumps waste without crossing abundant exchange; 5. side reaction is big, is prone to unbalanced syndrome in the treatment, hypotension, even shock.Conventional import hemo system makes the following medical institutions in general county and county be difficult to bear because of costing an arm and a leg, and influences applying of blood purification technology, makes a lot of patients that need give treatment to can not get treatment, is not suitable for the national conditions of present stage of china.At present, do not see as yet that both at home and abroad multi-functional apparatus for supporting life comes out, especially do not have the device of the treatment of compound bioartificial liver, kidney and blood purification associating to come out.

The liver function of humans and animals has: synthetic, and metabolism, detoxifcation, functions such as drainage.Bioartificial liver's research has: the animal liver perfusion, intersect and circulate, absorption perfusion, efficient dialysis, plasmapheresis.Bioartificial liver's present situation is at present: hepatocyte system (abdominal cavity, renal cortex, lung, spleen) hepatocyte transplantation in the body.Nearest progress has: microcarrier adheres to, and needs anti-the repulsion; The microcapsule parcel need not resist repulsion.External hepatocyte system: the hepatocyte dialysis, liver cell reactor, with calcium alginate gel as material, the perfusion of microcapsule parcel hepatocyte.Need perfect following target: primary hepatocyte or hepatic cell line are cultivated and need be reached more than the 108/ml; The a large amount of storages of human liver cell are standby, and it is perfect that artificial liver support system (ALSS) is installed.The compound extracorporeal circulation of blood device product of domestic present inanimate object artificial liver-artificial kidney-blood purification is sold.Strong " the saturating machine of artificial liver " by the exploitation of Hemo-cleanes company that is equipped with the release of limit company in Hong-Kong, its technical spirit is: extracorporeal circulation of blood produces negative pressure and malleation by the piston pump of design, acts on active carbon dialysis solution suspension.When the active carbon dialysis solution one side generation negative pressure at the dialyser semipermeable membrane, when acting on active carbon dialysis solution suspension one side, blood flows out to blood one side of dialyser from the arterial end of extracorporeal circulation conduit; When active carbon dialysis solution suspension one side at the dialyser semipermeable membrane produces malleation, the blood pressurized of dialyser semipermeable membrane blood one side, blood flows back in the body by the extracorporeal circulation of blood conduit.Motion and so forth promotes blood circulation.The feature of this technology has: (1) dialysis solution has made active carbon dialysis solution suspension into; (2) circulation pump has made vacuum pump (back and forth positive negative pressure pump) into by impeller pump; (3) other technology all be round above-mentioned 2 and the design the attached support prior art that helps.The major defect of this technical products (the saturating machine of The Biolo-gic System artificial liver) has: (1) design is complicated, has increased manufacturing cost; (2) function ratio is more single; (3) can not utilize the ingredient of biological activity cell, so the inanimate object active function as this equipment; (4) this technical products can only be as the treatment of general drug intoxication, the treatment of liver failure is equivalent to add in the conventional dialysis liquid use active carbon, can not carry out separating plasma and plasmapheresis, hemofiltration etc., and function singleness, effect is calmly difficult.

Purpose of the present invention is exactly a kind of apparatus for supporting life that designs at above deficiency.This apparatus for supporting life is blood purification technology (hemodiafiltration, hemoperfusion, the separating plasma displacement, dual separating plasma displacement, blood flow filters perfusion, hemodiafiltration, hemodialysis perfusion etc.) with liver, kidney bioreactor (by using the medical high polymer polysulfone membrane, the polyacrylonitrile film, the similar hemodialyzer sample that the contour biocompatible membrane hollow fibre of poly (ether sulfone) film pipe is made and/or the device of transfusion filters spline structure, the tube chamber of hollow fibre pipe is moving blood; Tube chamber external series gap at the pipe of hollow fibre inserting/or moving former generation liver, nephrocyte suspension or liver, kidney cell line is cultivated suspension, or with biotechnology liver, the nephrocyte of living, fill, be pasted and fixed in the outer wall gap of above-mentioned medical bio macromolecule hollow fibre pipe constitute) combine.The hollow fibre pipe of bioreactor can be with special bioreactor manufacture; Also available high-quality plasma separator or high performance transfusion filters replace temporarily." automatic hemo-dialyser " patented technology, number of patent application: " 95103196.1 " and " portable artificial kidney " patented technology, the patent No.: " 92101842.8 " are adopted in the dialysis solution circulation.So, no matter be acute and chronic renal failure, each phase uremia, still acute and chronic liver failure, hepatic coma, medicine, toxic poisoning, heroin poisoning, portion can use the treatment of this product.Make numerous medical institutions all can use this product, especially carry out the medical institutions of specific treatment.The present invention is fit to hospitals at different levels, and product has very strong adaptability, is with Chinese characteristics, and owns independent intellectual property, and has Development and Production future and application prospect on a large scale.This product will be numerous renal failures, each uremia phase, liver failure, and multiple organ dysfunction syndrome, drug intoxication, toxic poisoning, pesticide intoxication and heroin, opium, morphinism, the patient of addiction brings glad tidings.Purpose of the present invention will make a due contribution for blood purification and the life-support system of creating distinct Chinese characteristics.

The present invention is achieved in that a blood purification technology that is characterized in, bioartificial liver's extracorporeal circulation technology and biology artificial kidney extracorporeal circulation technology three combine together, are designed to brand-new apparatus for supporting life.This design makes an equipment have the function of three equipment.The present invention is a kind of medical apparatus for supporting life, it is characterized in that: by ductus arteriosus (1), roller pump (2), plasma separator (3a, 3b), blood connecting conduit (4), hemodialyzer (5), venous duct (6), bubble trap and sonac (6a), exhaustor (6b), vein pressure pipe (6c), blood plasma drainage tube (7a, 7b), blood plasma pump line and feedback blood plasma pipe (8), plasma perfusion pump (9), plasma perfusion arterial end pipe (10), blood plasma feeds back pump (11), plasma perfusion device (12), plasma circulation connecting conduit (13), liver, nephrocyte bioreactor (14), plasma perfusion vein end pipe (15), blood plasma memory (16), blood plasma memory exhaustor (17), dialysis solution circulation fairlead (18a, 18b, 18c), dialysis solution circulating pump and dialysis solution circulation pipe (19a), dialysis solution is heated and thermostat inlet tube (20), dialysis solution is heated and thermostat outlet and dialyser inlet tube (21), dialysis solution circulation pipe (22), dialyser outlet (23), dialysis solution circulation inlet tube (24a, 24b, 24c), dialysis fluid container (25a, 25b, 25c), dialysis solution and blood plasma memory are heated, thermostat and medium (26), dialysis fluid container platform (27), dialysis fluid container monitoring sensor (28), dialysis fluid container pick off supporting platform (29), casing (30), movable wheel (31), nephropathy treatment monitoring section (32), liver declines and gives treatment to monitoring section (33), zone of alarm (34), total computer monitoring district (35), venous pressure table (36), venous duct loop vascular clamp (37) constitutes apparatus for supporting life.

The working procedure of apparatus for supporting life of the present invention, it is characterized in that: dialysis solution blood circulation of the present invention relies on dialysis liquid pump (19a or 19b), from dialysis solution circulation fairlead (18a, 18b, 18c) drive, draw dialysis solution, from dialysis fluid container (25a, 25b, 25c) heat and thermostat inlet tube (20) to dialysis solution, through heating, dialysis solution after the weighing apparatus temperature, from dialysis solution heat and thermostat outlet (21) to dialysis solution circulation pipe (22), deliver to the vein end of dialyser (5), again from the arterial end dialysis solution outlet of dialyser (5) and dialysis solution circulation pipe (23) respectively through dialysis solution circulation inlet tube (24a, 24b, 24c) be back to dialysis fluid container (25a, 25b, 25c); By dialysis fluid container monitor pick off (28), experience the weight of dialysis fluid container (25a, 25b, 25c), converse the variation of dialysis solution capacity in the dialysis fluid container by weight and volumetric ratio, in treatment, monitor continuously with nephropathy treatment monitoring section (32); Blood circulation of the present invention is by ductus arteriosus (1) lead body inner blood, by roller pump (2), drive the arterial end that blood arrives plasma separator (3a), by blood connecting conduit (4), blood is introduced into the arterial end of dialyser (5) from the vein end of plasma separator (3a), again by venous duct (6), blood is introduced bubble trap (6a) from the vein end of dialyser (5), link to each other with venous pressure table (36) by vein pressure pipe (6c), pressure is imported into to venous pressure table (36), by the variation of nephropathy treatment district (32) monitoring venous pressure, when venous pressure surpasses the high limit of valve definite value or lower bound, the capital starts vein loop vascular clamp (37), occlude blood refluxes, and blood pump (2) stall simultaneously is when venous pressure is recovered normal range, the blood that flows down from bubble trap (6a) continues to move ahead, and flows back in patient's body; Plasma circulation of the present invention system is the blood plasma of separating from plasma separator (3a), be introduced into blood plasma memory (16) by blood plasma drainage tube (7), by the plasma perfusion circulation conduit (10) that communicates with blood plasma memory (16), pass through plasma perfusion pump (9) from the bottom of blood plasma memory (16), blood plasma is drawn and is circulated to the arrival end of plasma perfusion device (12), at the port of export of plasma perfusion device (12) by plasma circulation connecting conduit (13) and liver, the arrival end of nephrocyte bioreactor (14) links to each other, liver, the port of export of nephrocyte bioreactor (14) is drawn blood plasma by plasma perfusion circulation conduit (15) and is back to blood plasma memory (16), feed back pump (11) and blood plasma feedback pipe (8) by blood plasma, in the blood plasma memory (16) through perfusion repeatedly, purified regulating liver-QI, blood plasma after the nephrocyte bioreactor is had an effect, deliver to venous duct (6) with tee T, feed back to give the patient, liver in the treatment treatment monitoring section (33) that declines that is controlled at automatically of plasma circulation system is carried out; The heat thermostat and the warm medium (26) of heating, weigh of dialysis solution of the present invention and blood plasma memory are to medium heat, weigh temperature and be subjected to the monitoring of total monitoring section computer by heating member; The total monitoring section of the present invention (35), in treatment to kidney, liver multiple organ failure, MOF when depletion is given treatment to simultaneously or separately, (32) and (33) are carried out synchronous monitoring, when any part breaks down at work, alarm signal is sent by zone of alarm (34) in the capital, and processing method is provided, after treated recovery is normal, report to the police promptly to return to automatically and treat alarm condition, shown in Fig. 1 a, 1b.

The present invention realizes like this, it is by ductus arteriosus (1), roller pump (2), plasma separator (3a, 3b), blood connecting conduit (4), hemodialyzer (5), venous duct (6), bubble trap and sonac (6a), exhaustor (6b), vein pressure pipe (6c), blood plasma drainage tube (7a, 7b), blood plasma pump line and feedback blood plasma pipe (8), plasma perfusion pump (9), plasma perfusion arterial end pipe (10), blood plasma feeds back pump (11), plasma perfusion device (12), plasma circulation connecting conduit (13), liver, nephrocyte bioreactor (14) plasma perfusion vein end pipe (15), blood plasma memory (16), blood plasma memory exhaustor (17), dialysis solution circulation fairlead (18a, 18b, 18c), dialysis solution circulating pump and dialysis solution circulation pipe (19a), dialysis liquid pump (19b), dialysis solution is heated and thermostat inlet tube (20), dialysis solution heat thermostat outlet and dialyser inlet tube (21), dialysis solution circulation pipe (22), dialyser outlet (23), dialysis solution circulation inlet tube (24a, 24b, 24c), dialysis fluid container (25a, 25b, 25c), dialysis solution and blood plasma memory are heated, thermostat and medium (26), dialysis fluid container platform (27), dialysis fluid container monitoring sensor (28), dialysis fluid container pick off supporting platform (29), casing (30), movable wheel (31), nephropathy treatment monitoring section (32), liver declines and gives treatment to monitoring section (33), zone of alarm (34), total computer monitoring district (35), venous pressure table (36), venous duct loop vascular clamp (37) constitutes.

The blood circulation method of work of this technical scheme is the blood that comes from ductus arteriosus (1), drive the arterial end that proceeds to plasma separator (3a) by blood pump (2), flow out the back to blood connecting conduit (4) from the vein end of plasma separator (3a), introduce the arterial end of dialyser (5) from blood connecting conduit (4), introduce bubble trap (6a) from the vein end transvenous catheter (6) of dialyser (5), continuing to move ahead passes back in patient's the body; The plasma circulation system of this technical scheme is the blood plasma drainage tube ((7a) from the arterial end blood plasma tap of plasma separator (3a), introduce the arrival end of plasma separator (3b), introduce blood plasma memory (16) from the port of export of plasma separator (3b) through blood plasma drainage tube (7a) again, by plasma perfusion arterial end pipe (10), circular flow is to the arrival end of plasma perfusion device (12) under the driving of plasma perfusion pump (9), the port of export at plasma perfusion device (12) is connected with plasma circulation connecting conduit (13), the blood plasma that comes from plasma perfusion device (12) continues to move ahead, enter liver, the arrival end of nephrocyte bioreactor (14), from liver, the effusive blood plasma of nephrocyte bioreactor (14) port of export, draw through blood plasma perfusion vein end pipe (15) and to be back to blood plasma memory (16), in the blood plasma memory (16) if too much air arranged, then get rid of through blood plasma memory exhaustor (17), through circulation repeatedly, perfusion, with the blood plasma after the generation biological agent in liver or nephrocyte bioreactor (14), deliver to venous duct (6) by blood plasma pump line and feedback blood plasma pipe (8) by tee T and also feed back to the patient; The dialysis solution blood circulation of this technical scheme is by dialysis liquid pump (19a) or (19b) to drive dialysis solution from the dialysis solution fairlead (18a that circulates, 18b, 18c) dialysis solution is drawn the back and enter by the dialysis liquid pump that dialysis solution is heated and thermostat inlet tube (20), heat and thermostat outlet and dialyser inlet tube (21) to dialysis solution circulation (22) and the vein end dialysis solution that enters dialysis solution (5) portalled from dialysis solution through the dialysis solution of the temperature of heating and weigh, dialysis solution from the arterial end dialysis solution of dialyser (5) is gone into to portal and discharged circulates to dialysis solution circulation inlet tube (24a by dialyser outlet (23), 24b, 24c) also backflow enters dialysis fluid container (25a, 25b, 25c); Dialysis solution and blood plasma memory are heated, thermostat and medium (26), blood pump (2), and dialysis liquid pump (19a) and (19b), venous pressure table (36), venous duct loop vascular clamp (37) is monitored by nephropathy treatment monitoring section (32); When dialysis solution and medium too high or too low for temperature surpasses threshold values, stop automatically heating or heating automatically; When venous pressure is too high or too low when surpassing threshold values, venous pressure table (36) breath to the nephropathy of delivering a letter is given treatment to monitoring section (32) and is sent alarm signal; When the amount of air in the bubble trap (6a) of blood circulation venous duct (6) surpasses the plane that limits, external ultrasound detector sensor at bubble trap reaches nephropathy monitoring section (32) to information, by computer domination electromagnetic valve push-and-pull vein loop vascular clamp (37) blocking blood flow, blood pump (2) stops operating, prevent that alveolate blood from entering patient's body and going into: plasma perfusion pump (9) can be the different segment of same roller pump with dialysis liquid pump (19a), under the situation of this design, working procedure is subjected to nephropathy treatment district (32) monitoring; The decline monitoring in treatment district (33) of liver is accepted in the work that blood plasma feeds back pump (11), and blood plasma feeds back pump (11) and plasma perfusion pump (9) but also independent control duty, shown in Fig. 2 a, 2b.

The present invention realizes like this, it is by ductus arteriosus (1), roller pump (2), the filter side (3) of dialysis filter, the dialyser side (5) of dialysis filter, venous duct (6), bubble trap and sonac (6a), exhaustor (6b), vein pressure pipe (6c), filtered solution drainage tube (7), filtered solution feeds back pipe (8), filtered solution perfusion stream pump (9), filtered solution perfusion circulation pipe (10), filtered solution feeds back pump (11), filtered solution perfusion device (12), filtered solution circulation connecting conduit (13), liver, kidney bioreactor (14), filtered solution perfusion circulation conduit (15), filtered solution memory (16), exhaustor (17), dialysis solution circulation fairlead (18a, 18b, 18c), dialysis liquid pump (19a, 19b), the dialysis solution thermostat inlet tube (20) of heating, the dialysis solution thermostat fairlead (21) of heating, dialysis filter dialyser side dialysis solution entry conductor (22), dialysis filter dialyser port of export conduit (23), dialysis solution circulation inlet tube (24a, 24b, 24c), dialysis fluid container (25a, 25b, 25c), dialysis solution heat thermostat and medium (26), dialysis solution weight detecting platform (27), pressure transducer (28), dialysis fluid container is supported detection platform (29), casing (30), universal caster wheel (31), nephropathy treatment monitoring section (32), liver declines and gives treatment to monitoring section (33), zone of alarm (34), total monitoring section (35), venous pressure table (36), venous duct loop vascular clamp (37) constitutes another life-support system, its method of work principal character is: blood circulation is to drive the filter side (3) that arrives dialysis filter from the blood that ductus arteriosus (1) comes through roller pump (2), and to dialyser one side (5) of dialysis filter, transvenous catheter (6) enters bubble trap (6a) again,, be back at last in patient's body again to the far-end of venous duct from bubble trap (6a); The filtered solution of discharging from the filtered solution tap of dialysis filter, drain into filtered solution memory (16) through filtered solution drainage tube (7), under the driving of filtered solution infusion pump (9), by with the filtered solution perfusion circulation pipe (10) of filtered solution memory (16) bottom connection, the guiding filtered solution is to filtered solution perfusion device (12), by filtered solution circulation connecting conduit (13), to liver, kidney bioreactor (14), again through filtered solution perfusion circulation conduit (15), be back to filtered solution memory (16), through circulation and liver repeatedly, filtered solution after the kidney bioreactor reacts, feed back pipe (8) by filtered solution, feed back at filtered solution under the driving of pump (11), afferent veins conduit (6), feed back to the patient by venous duct (6): dialysis fluid container (25a, 25b, dialysis solution 25c), through dialysis solution circulation fairlead (18a, 18b, 18c), under the driving of dialysis liquid pump (19a or 19b), be recycled to the dialysis solution thermostat inlet tube (20) of heating, the dialysis solution of weighing apparatus after the temperature enters dialysis filter from dialysis solution thermostat fairlead (21) to the dialyser side dialysis solution arrival end pipe (22) of dialysis filter of heating through heating, continue to move ahead from the dialyser side dialysis solution port of export conduit (23) of dialysis filter, through dialysis solution circulation inlet tube (24a, 24b, 24c) enter dialysis fluid container; By (32), (33) and total monitoring section (35) respectively to extracorporeal blood circulation system, filtered solution perfusion blood circulation, dialysis solution blood circulation, dialysis solution heat the weighing apparatus warm system, the venous pressure monitoring system, extracorporeal circulation of blood air monitering security system is monitored, is controlled, shown in Fig. 3 a, 3b.

The present invention can also be achieved in that it is by ductus arteriosus (1), roller pump (2), plasma separator (3), venous duct (6), bubble trap and sonac (6a), exhaustor (6b), vein pressure pipe (6c), blood plasma drainage tube (7), blood plasma pump line and feedback blood plasma pipe (8), plasma perfusion pump (9), plasma perfusion arterial end pipe (10), blood plasma feeds back pump (11), plasma perfusion device (12), plasma circulation connecting conduit (13), liver, nephrocyte bioreactor (14), plasma perfusion vein end pipe (15), blood plasma memory (16), exhaustor (17), dialysis solution and blood plasma memory heat thermostat and medium (26), nephropathy monitoring section (32), the liver treatment monitoring section (33) that declines, zone of alarm (34), total monitoring section (35), venous pressure table (36), vein loop vascular clamp (37) constitutes another life-support system; Arterial blood moves ahead under the driving of roller pump (2) through ductus arteriosus (1), arrive the arterial end of plasma separator (3), the vein end and the venous duct (6) that arrive plasma separator behind the blood plasma separator link, and blood flow continues to move ahead behind bubble trap (6a), is back in patient's body; The blood plasma of separating from plasma separator (3), through blood plasma drainage tube (7) drain to blood plasma memory (16), through blood plasma perfusion arterial end pipe (10), under the driving of plasma perfusion pump (9), arrive plasma perfusion device (12), by plasma circulation connecting conduit (13), arrive liver, nephrocyte bioreactor (14), blood plasma from liver, nephrocyte bioreactor (14) discharge, flow back to blood plasma memory (16) through blood plasma perfusion vein end pipe (15), through the blood plasma pump pipe and feed back blood plasma pipe (8) and continue to move ahead to venous duct (6) and be back in patient's body; The heat weighing apparatus temperature monitoring of heating of thermostat and medium (26) of dialysis solution and blood plasma memory, the monitoring of the high and low threshold value of venous pressure and warning, closing automatically of venous blood pipe clamp (37), the monitoring of bubble trap (6a) is given treatment to monitoring section (32) monitoring by nephropathy, be subjected to the monitoring of total monitoring section computer (35), shown in Fig. 4 a, 4b.

The present invention realizes like this, it is by ductus arteriosus (1), blood pump (or blood plasma feedback pump) (11), blood (or blood plasma) perfusion device (12), blood plasma (or blood) circulation connecting conduit (13), liver, nephrocyte bioreactor (14), venous duct (6), bubble trap and sonac (6a), exhaustor (6b), vein pressure pipe (6c), nephropathy monitoring section (32), the liver monitoring section (33) that declines, zone of alarm (34), total monitoring section (35), venous pressure table (36), vein loop vascular clamp (37) constitutes another life-support system; The blood of drawing in patient's body, under the driving of blood pump (or blood plasma feedback pump) (11), arrive blood (or blood plasma) perfusion device (12) through ductus arteriosus (1), the blood of discharging from blood (or blood plasma) perfusion device arrives liver, nephrocyte bioreactor (14) through blood plasma (or blood) circulation connecting conduit (13), the blood of discharging from liver, nephrocyte bioreactor (14) arrives bubble trap (6a) from venous duct (6), and blood continues to move ahead and is back in patient's body; When venous pressure is too high or too low when surpassing threshold value, import venous pressure table (36) into by vein pressure pipe (6c), through nephropathy treatment monitoring section (32) analyzing and processing, and report total monitoring section computer (35), and promptly to report to the police, blood pump suspends, after treated recovery was normal, blood pump restarted running; When the air in the bubble trap (6a) too much or in the blood has bubble, when surpassing the threshold definite value, after finding out by the ultrasonic detector at bubble trap place, signal is reached nephropathy treatment district (32), report to total monitoring section (35), automatically closed by total monitoring section computer instruction vein loop vascular clamp (37), blocking-up has the blood of air to flow in patient's body; Shown in Fig. 5 a, 5b.

The present invention realizes like this, it is by ductus arteriosus (1), blood pump (2), dialyser (5), vein pressure pipe (6), bubble trap and sonac (6a) exhaustor (6b) vein pressure pipe (6c), dialysis solution circulation fairlead (18a, 18b, 18c), dialysis liquid pump and dialysis solution circulation pipe (19a), dialysis liquid pump (19b), dialysis solution is heated and thermostat inlet tube (20), dialysis solution is heated and thermostat outlet (21), dialysis solution circulation pipe (22), dialyser outlet (23), dialysis solution circulation inlet tube (24a, 24b, 24c), dialysis fluid container (25a, 25b, 25c), dialysis solution and blood plasma memory heat thermostat and medium (26), dialysis fluid container platform (27), dialysis fluid container monitoring sensor (28), dialysis fluid container pick off supporting platform (29), casing (30), movable wheel (31), nephropathy treatment monitoring section (32), zone of alarm (34), the another apparatus for supporting life system that total monitoring section (35), venous pressure table (36), vein loop vascular clamp (37) constitute; After patient's blood is drawn in the body, through ductus arteriosus (1) arrival dialyser (5) under the driving of blood pump (2), blood is discharged the laggard vein conduit (6) of going into from the vein end of dialyser (5), and continuing to move ahead arrives bubble trap (6a), moves ahead and gets back in patient's the body; From dialysis solution circulation fairlead (18a, 18b, the dialysis solution of 18c) drawing respectively, under the attraction of dialysis liquid pump (19a or 19b) drives, arriving dialysis solution heats and thermostat inlet tube (20), after the weighing apparatus temperature of heating, discharge from the dialysis solution thermostat outlet (21) of heating, proceed to dialysis solution circulation pipe (22), an end that moves ahead again with dialyser (5) joins, dialysis solution is through the dialyser inlet tube (24a that circulates, 24b, 24c) flow into dialysis fluid container (25a respectively, 25b, 25c), after circulation reaches regular hour and number of times repeatedly, more change dialysis fluid container (25a, 25b, 25c), continue circulation with fresh dialysis solution, up to finishing dialysis ultrafiltration treatment; In the process of dialysis ultrafiltration treatment, dialysis fluid container monitoring sensor (28) is monitored the weight of dialysis fluid container continuously, and information is sent to (32), when the weight (volume) of dialysis fluid container surpasses predetermined threshold value and when too high or too low, total monitoring section computer (35) is promptly pointed out and is shown and warning, after making corresponding processing recovery normally, alarm condition is promptly removed; When venous pressure is too high or too low when surpassing threshold value, promptly report to the police (32), handle recover normal after, alarm condition is promptly removed; When the bubbles volume in the bubble trap surpasses the threshold level line, sonac at the bubble trap place promptly reaches information (32), close venous duct loop vascular clamp (37) immediately, roller pump (2) stops operating, when the blood levels face in the bubble trap being improved or having extracted the air in the bubble trap out, vein loop vascular clamp (37) is open automatically, and roller pump (2) recovers to rotate, and vein loop vascular clamp returns to the normal position; When dialysis solution and blood plasma memory heat that the temperature of thermostat and medium (26) surpasses the threshold value of predetermined temperature and when too high or too low, (32) promptly stop to heat or heating, and make dialysate temperature remain on the normal range that it is fixed that one is weighed; Shown in Fig. 6 a, 6b.

Below in conjunction with accompanying drawing the present invention is described in further detail:

Fig. 1 a, Fig. 1 b are a kind of operation principle of the present invention and primary structure and office of the main portion of the Appearance Panel sketch map.1-ductus arteriosus among the figure, the 2-roller pump, the 3-plasma separator, 4-blood connecting conduit, the 5-hemodialyzer, the 6-venous duct, 6a-bubble trap and sonac, the 6b-exhaustor, 6c-vein pressure pipe, 7-blood plasma drainage tube, 8-blood plasma pump line and feedback blood plasma pipe, 9-plasma perfusion pump, 10-plasma perfusion arterial end pipe, 11-blood plasma feeds back pump, 12-plasma perfusion device, 13-plasma circulation connecting conduit, the 14-liver, the nephrocyte bioreactor, 15-plasma perfusion vein end pipe, 16-blood plasma memory, 17-blood plasma memory exhaustor, 18a, 18b, the special circulation fairlead of 18c-dialysis solution, the 19a-liquid pump of dialysing, the 19b-liquid pump of dialysing, the 20-dialysis solution is heated and the thermostat inlet tube, and the 21-dialysis solution is heated and the thermostat outlet, 22-dialysis solution circulation pipe and dialyser connection tube, 23-dialyser outlet, 24a, 24b, 24c-dialysis solution circulation inlet tube, 25a, 25b, the 25c-dialysis fluid container, 26-dialysis solution and blood plasma memory are heated, thermostat and medium, 27-dialysis solution platform, 28-dialysis fluid container monitoring sensor, 29-dialysis fluid container pick off supporting platform, 30-casing, the movable wheel of 31-, 32-nephropathy treatment monitoring section, the 33-liver treatment monitoring section that declines, the 34-zone of alarm, the total computer monitoring of 35-district, 36-venous pressure table, 37-venous duct loop vascular clamp, more than each critical piece constitute separating plasma+plasma perfusion of the present invention+bioreactor+blood dialysis ultrafiltration or hemodiafiltration+or pure hemofiltration or simple blood ultrafiltration system; With angiographic neeclle or vascular catheterization patient's blood is drawn in body, drain into the 3-plasma separator again through 1-ductus arteriosus drain to 2-blood pump, after the vein end outflow of plasma separator, drain into 5-dialyser or filter by 4-blood connecting conduit, introduce 6a-bubble trap and sonac from the blood of dialyser or filter discharge by the 6-venous duct, draw by transvenous catheter behind the bubble trap and get back in patient's body; The blood plasma of separating from the 3-plasma separator, enter 16-blood plasma memory through 7-blood plasma drainage tube, under the driving of 9-plasma perfusion pump, arrive 12-plasma perfusion pump by 10-plasma perfusion arterial guiding blood plasma, after going out the blood plasma infusion pump, arrive the 14-liver through the connecting tube of 13-plasma circulation, the nephrocyte bioreactor, from liver, after the nephrocyte bioreactor is discharged, be back to 16-blood plasma memory through 15-plasma perfusion vein end pipe, through circulation repeatedly, fully plasma perfusion and have an effect with liver or nephrocyte bioreactor after blood plasma, feed back to the 6-venous duct by 8-blood plasma pump line and feedback blood plasma pipe, be back to afterwards in patient's body; The blood circulation dynamic pressure that venous pressure table 36 is being monitored from bubble trap changes, the air plane of blood plane in the bubble trap and the bubble in the blood in bubble trap and sonac 6a-continuous monitoring, the temperature of filtered solution in dialysis solution and blood or blood plasma or the filtered solution memory or blood plasma in heat thermostat and medium 26 continuous monitorings of dialysis solution, the variation that dialysis fluid container weight (volume) in 28 continuous monitorings of dialysis fluid container monitoring sensor, above-mentioned four continuous monitor systems are in case threshold value occurs surpassing, pick off passes to nephropathy treatment monitoring section 32 to information immediately, and reach total monitoring section computer 35, respectively venous pressure is monitored by total monitoring section computer 35, dialysis solution is heated, the weighing apparatus temperature, air monitering, dialysis fluid container weight surpass the variation of threshold value and send following indication and action.Venous pressure is too high or too low: report to the police immediately (1); (2) roller pump stall; (3) the dialysis solution thermostat of heating stops to heat or heating.When the horizontal plane that has bubble to arrive sonac in bubble or the bubble trap blood was arranged in the bubble trap: reported to the police immediately (1); (2) vein loop bloody path vascular clamp 37 is closed immediately; (3) roller pump stall immediately.When dialysate temperature was too high or too low above threshold value: reported to the police immediately (1); (2) dialysis

liquid pump

19a or 19b stop operating immediately, end the dialysis solution circulation.When the dialysis solution capacity surpassed threshold value: reported to the police immediately (1); (2) point out the treatment measures that to take.

Fig. 2 a, Fig. 2 b are another duty principle of the present invention and primary structure and the Appearance Panel partial schematic diagram.1-ductus arteriosus among the figure, the 2-roller pump, 3a, the 3b-plasma separator, 4-blood connecting conduit, the 5-hemodialyzer, the 6-venous duct, 6a-bubble trap and sonac, the 6b-exhaustor, 6c-vein pressure pipe, 7a, 7b-blood plasma drainage tube, 8-blood plasma pipe and feedback blood plasma pipe, 9-plasma perfusion pump, 10-plasma perfusion arterial end pipe, 11-blood plasma feeds back pump, 12-plasma perfusion device, 13-plasma circulation connecting conduit, the 14-liver, the nephrocyte bioreactor, 15-plasma perfusion vein end pipe, 16-blood plasma memory, 17-blood plasma memory exhaustor, 18a, 18b, 18c-dialysis solution circulation fairlead, 19a-dialysis solution circulating pump and dialysis solution circulation pipe, the 19b-liquid pump of dialysing, the 20-dialysis solution is heated and the thermostat inlet tube, and the 21-dialysis solution is heated and thermostat outlet and dialyser inlet tube, 22-dialysis solution circulation pipe, 23-dialyser outlet, 24a, 24b, 24c-dialysis solution circulation inlet tube, 25a, 25b, the 25c-dialysis fluid container, 26-dialysis solution and blood plasma memory are heated, thermostat and medium, 27-dialysis fluid container platform, 28-dialysis fluid container monitoring sensor, 29-dialysis fluid container pick off supporting platform, 30-casing, the movable wheel of 31-, 32-nephropathy treatment monitoring section, the 33-liver treatment monitoring section that declines, the 34-zone of alarm, the total computer monitoring of 35-district, 36-venous pressure table, 37-venous duct loop vascular clamp, more than each critical piece constitute a separating plasma of the present invention+secondary separating plasma+plasma perfusion+liver, nephrocyte bioreactor+blood dialysis ultrafiltration or hemodiafiltration+pure hemofiltration or simple blood ultrafiltration system; Adopt vascular puncture or vascular catheterization that patient's blood is drawn in body, through the drain of 1-ductus arteriosus to the 2-roller pump, under the driving of roller pump, arrive plasma separator of 3a-, through 4-blood connecting conduit blood drainage is arrived 5-dialyser or filter, introduce 6a-bubble trap and sonac from the blood that dialyser or filter are discharged by the 6-venous duct, the blood by bubble trap and sonac draws through the 6-venous duct again to be got back in patient's body; The blood plasma of separating from plasma separator of 3a-, cause 3b-secondary plasma separator through 7b-blood plasma drainage tube, cause the blood plasma memory by the unsegregated blood plasma of 3b-secondary plasma separator by 7a-blood plasma drainage tube, enter the blood plasma of blood plasma memory, guide to 9-plasma perfusion pump and be driven arrival 12-plasma perfusion device through 10-plasma perfusion arterial end pipe, through the blood plasma of plasma perfusion device by the drain of 13-plasma circulation connecting conduit to the 14-liver, the nephrocyte bioreactor, by the 14-liver, blood plasma behind the nephrocyte bioreactor, draw by 15-plasma perfusion vein end pipe and to be back to 16-blood plasma memory, through circulating repeatedly and liver, blood plasma after the nephrocyte bioreactor fully acts on is fed back to the patient by the 6-venous duct by 8-blood plasma pump line and feedback blood plasma pipe again; By the blood plasma that 3b-secondary plasma separator is separated, directly introduce the 6-venous duct by drainage tube, feed back and give the patient.The blood circulation dynamic pressure that venous pressure table 36 is being monitored from bubble trap changes, the air plane of blood plane in the bubble trap and the bubble in the blood in bubble trap and ultrasonic sensing 6a continuous monitoring, temperature in dialysis solution and filtered solution or the blood plasma memory in heat thermostat and medium 26 continuous monitorings of dialysis solution, the variation that dialysis fluid container weight (volume) in 28 continuous monitorings of dialysis fluid container monitoring sensor, above-mentioned four continuous monitor systems are in case threshold value occurs surpassing, pick off is communicated to nephropathy treatment monitoring section 32 to information immediately, and reach total monitoring section computer 35, respectively venous pressure is monitored by total monitoring section computer 35, dialysis solution is heated and is weighed temperature, air monitering, dialysis fluid container weight surpass the variation of threshold value and send following indication and action.When the horizontal plane that has bubble to arrive sonac in bubble or the bubble trap blood was arranged in the bubble trap: reported to the police immediately (1); (2) vein loop vascular clamp 37 is closed immediately; (3) roller pump stall immediately.When dialysate temperature was too high or too low above threshold value: reported to the police immediately (1); (2) dialysis

liquid pump

Fig. 3 a, Fig. 3 b are another duty principle of the present invention and primary structure and the Appearance Panel branch sketch map.1-ductus arteriosus among the figure, the 2-roller pump, the 3-filter, the 5-dialyser, the 6-venous duct, the 6a-bubble trap, the 6b-exhaustor, 6c-vein pressure pipe, 7-filtered solution drainage tube, the 8-filtered solution feeds back pipe, 9-filtered solution infusion pump, 10-filtered solution perfusion circulation pipe, the 11-filtered solution feeds back pump, 12-filtered solution perfusion device, 13-filtered solution circulation connecting conduit, 14-liver, the nephrocyte reactor, 15-filtered solution perfusion circulation conduit, 16-filtered solution memory, 17-exhaustor, 18a, 18b, 18c-dialysis solution circulation fairlead, 19a, the 19b-liquid pump of dialysing, the 20-dialysis solution thermostat inlet tube of heating, the 21-dialysis solution thermostat fairlead of heating, 22-dialysis filter dialyser side dialysis solution arrival end conduit, 23-dialysis filter dialyser port of export conduit, 24a, 24b, 24c-dialysis solution circulation inlet tube, 25a, 25b, 25c-dialysis fluid container, 26-dialysis solution heat thermostat and medium, 27-dialysis solution weight monitoring platform, the 28-pressure transducer, the 29-dialysis fluid container is supported monitoring platform, 30-casing, the 31-universal caster wheel, 32-nephropathy treatment monitoring section, the 33-liver treatment monitoring section that declines, the 34-zone of alarm, the total monitoring section of 35-, 36-venous pressure table, 37-venous duct loop vascular clamp more than constitutes hemofiltration+blood dialysis ultrafiltration of the present invention+filtered solution perfusion+liver, the kidney bioreactor is another life-support system; Adopt vascular puncture or puncture conduit, lead to patient's blood external, arrive roller pump 2 through ductus arteriosus 1, under the driving of roller pump 2, arrive filter 3, arrive dialyser 5 through filter 3, the blood transvenous catheter 6 of drawing from dialyser 5 arrives bubble trap 6a, and blood is sent back in patient's body from venous duct 6; The filtered solution that is leached from filter 3, drain into filter filtered solution memory 16 through filtered solution drainage tube 7, be arranged in the filtered solution of filtered solution memory 16, through filtered solution perfusion circulation conduit 10, filtered solution is drawn, under the driving of filtered solution infusion pump 9, arrive filtered solution perfusion device 12, arrive liver through filtered solution circulation connecting conduit 13, nephrocyte bioreactor 14, by filtered solution perfusion circulation conduit 15 filtered solution is sent back to the filtered solution memory again, through perfusion regulating liver-QI repeatedly, filtered solution after the kidney bioreactor is had an effect feeds back pipe 8 by filtered solution, under the driving of filtered solution feedback pump 11, deliver to venous duct 6, feed back and give the patient; Dialysis solution is respectively from

dialysis fluid container

25a, 25b, 25c-is through dialysis solution circulation fairlead 18a, 18b, 18c-draws, at dialysis solution driving pump 19a, under the driving of 19b-, through 18a, 18b, 18c-guides to the dialysis solution thermostat inlet tube 20 of heating, from the dialysis solution dialysis solution that thermostat fairlead 21 draws of heating, proceed to dialysis filter dialyser side dialysis solution arrival end pipe 22, dialysis solution from dialyser 5 discharges, deliver to dialysis solution circulation inlet tube 24a by dialysis filter dialyser port of export conduit 23 again, 24b, 24c returns

dialysis fluid container

25a, 25b, 25c; The blood circulation dynamic pressure that venous pressure table 36 is being monitored from bubble trap changes, the air of blood plane in the bubble trap and the bubble in the blood in bubble trap and sonac 6a continuous monitoring, the temperature of filtered solution in dialysis solution and the filtered solution memory in heat thermostat and medium 26 continuous monitorings of dialysis solution, the variation that dialysis fluid container weight (volume) in 28 continuous monitorings of dialysis fluid container monitoring sensor, above-mentioned four continuous monitor systems are in case threshold value occurs surpassing, pick off passes to nephropathy treatment monitoring section 32 to information immediately, and reach total monitoring section computer 35, respectively venous pressure is monitored by total monitoring section computer 35, dialysis solution is heated and is weighed temperature, air monitering, dialysis fluid container weight surpasses the variation of threshold value and sends following indication and action, and venous pressure is too high or too low: report to the police immediately (1); (2) roller pump stall; (3) the dialysis solution thermostat of heating stops to heat or heating.When the horizontal plane that has bubble to arrive sonac in bubble or the bubble trap blood was arranged in the bubble trap: reported to the police immediately (1); (2) venous duct loop vascular clamp 37 is closed immediately; (3) roller pump 2 stall immediately.When dialysate temperature was too high or too low above threshold value: reported to the police immediately (1); (2) the dialysis solution circulation is ended in dialysis

liquid pump

19a or 19b stall immediately.When the dialysis solution capacity surpassed threshold value: reported to the police immediately (1); (2) point out the treatment measures that to take.

Fig. 4 a, Fig. 4 b is another working state schematic representation of the present invention, 1-ductus arteriosus among the figure, 2-roller pump, the 3-plasma separator, 6-venous duct, 6a-bubble trap and sonac, the 6b-exhaustor, 6c-vein pressure pipe, 7-blood plasma drainage tube, 8-blood plasma pump line and blood plasma feed back pipe, 9-plasma perfusion pump, 10-plasma circulation ductus arteriosus, 11-blood plasma feeds back pump, 12-plasma perfusion device, 13-plasma circulation connecting conduit, the 14-liver, the nephrocyte bioreactor, 15-plasma perfusion vein end pipe, 16-blood plasma memory, the 17-exhaustor, 26-dialysis solution and blood plasma memory are heated, thermostat and medium, 36-venous pressure table, 37-vein loop vascular clamp; More than constitute separating plasma+plasma perfusion of the present invention+liver, nephrocyte bioreactor system; Patient's blood is drawn in patient's body with puncture needle or intubate, arrive roller pump 2 through ductus arteriosus 1, under the driving of roller pump 2, arrive the arterial end of plasma separator 3, after blood is discharged from the vein end of plasma separator, guide to bubble trap and sonac 6a by venous duct, behind 6a, continue to move ahead, transvenous catheter 6 sends back to blood in patient's the body; The blood plasma of separating from plasma separator 3, introduce blood plasma memory 16 through blood plasma drainage tube 7, by plasma circulation ductus arteriosus 10 blood plasma is drawn from the blood plasma memory, under the driving of plasma perfusion pump 9, arrive blood perfusion device 12, behind the plasma perfusion device, through blood plasma circulation connecting conduit 13, blood plasma is introduced liver, nephrocyte bioreactor 14,, send back to blood plasma memory 16 through blood plasma perfusion vein end pipe 15 by the blood plasma behind liver, the kidney bioreactor 14; Through the blood plasma after perfusion, regulating liver-QI or the effect of nephrocyte bioreactor repeatedly, feed back pipe 8 by blood plasma pump line and blood plasma, feed back at blood plasma under the driving of pump 11, deliver to venous duct 6, feed back at last and give the patient.Dialysis solution and blood plasma memory are heated, thermostat 26 is continuously being monitored the temperature of blood plasma memory, venous pressure table 36 is continuously being monitored the venous pressure of vein end blood circuit, bubble trap and sonac 6a are continuously monitoring the bubble in the blood plane and blood in the bubble trap, in case it is too high or too low that the temperature of blood plasma memory 16 surpasses threshold value, it is too high or too low that venous pressure surpasses threshold value, in decline of bubble trap blood plane or the blood bubble is arranged, there are three kinds of information to reach decline treatment monitoring section and passing of 33-liver respectively to the total monitoring section computer of 35-, send three kinds of indications respectively by the total monitoring section computer of 35-: (1) blood plasma memory is too high or too low for temperature, instructs 26 dialysis solution and blood plasma memory to heat, thermostat stops to heat or heating; (2) venous pressure is too high or too low, and instruction roller pump 2, blood plasma charge pump 9, blood plasma feed back pump 11 stalls; (3) in the too low or blood of blood plane bubble is arranged in the bubble trap, instruction vein loop vascular clamp 37 is closed roller pump 2 stalls simultaneously immediately, blood plasma feeds back pump 11 stalls, 9 stalls of plasma perfusion pump, when after exhaustor is extracted the gas among the bubble trap 6a out, the running that promptly recovers above-mentioned three pumps.

Fig. 5 a, Fig. 5 b are another duties of the present invention, 1-ductus arteriosus among the figure, 11-plasma perfusion pump, the 12-blood perfusion device, 13-blood circulation connecting conduit, 14-liver, nephrocyte bioreactor, the 6-venous duct, 6a-bubble trap and sonac, 6b-exhaustor, 6c-vein pressure pipe, 33-liver decline and give treatment to district, 34-zone of alarm, the total monitoring section of 35-, 36-venous pressure table, 37-vein loop vascular clamp, more than each parts constitute the design's hemoperfusion+liver or nephrocyte bioreactor system; Patient's blood is drawn in patient's body with puncture needle or intubate, by ductus arteriosus 1, under the driving of hemoperfusion pump 11, arrive blood perfusion device 12, by blood circulation connecting conduit 13, to liver or nephrocyte bioreactor 14, the blood transvenous catheter 6 of discharging from liver or nephrocyte bioreactor 14 is back in patient's body blood drainage; Venous pressure table 36, bubble trap and sonac 6a are carrying out continuous monitoring, and at any time institute's data monitored is passed to liver decline treatment district's computer 33 and total monitoring section computer 35, in case venous pressure is too high or too low, in blood plane excessive descent in the bubble trap or the blood bubble is arranged, there are two kinds of information to reach decline treatment district of 33-liver respectively, and pass to the total monitoring section computer of 35-, send two kinds of instructions respectively by 35 total monitoring section computers: (1) venous pressure is too high or too low, instruction plasma perfusion pump 11 or roller pump 2 stalls, 34 zone of alarm are reported to the police simultaneously; (2) in the too low or blood of blood plane bubble is arranged in the bubble trap, instruction vein loop vascular clamp 37 is closed immediately, and plasma perfusion pump 11 or roller pump 2 stop operating simultaneously, and report to the police this moment 34.After suitable processing recovered normally, warning was eliminated, and roller pump 11 recoveries are rotated, and vein loop vascular clamp 37 is opened automatically, returns to the state for preparing when reporting to the police.

Fig. 6 a, Fig. 6 b is another duty of the present invention, 1-ductus arteriosus among the figure, the 2-roller pump, the 5-dialyser, filter, blood perfusion device, dialyser+filter, the 6-venous duct, 6a-bubble trap and sonac, the 6b-exhaustor, 6c-vein pressure pipe, 18a, 18b, 18c-dialysis solution circulation fairlead, 19a-dialysis liquid pump and dialysis solution circulation pipe, the 19b-liquid pump of dialysing, the 20-dialysis solution is heated and the thermostat inlet tube, the 21-dialysis solution is heated and the thermostat outlet, 22-dialysis solution circulation pipe, 23-dialyser outlet, 24a, 24b, 24c-dialysis solution circulation inlet tube, 25a, 25b, the 25c-dialysis fluid container, 26-dialysis solution and blood plasma memory heat thermostat and medium, 27-dialysis fluid container platform, 28-dialysis fluid container monitoring sensor, 29-dialysis fluid container pick off supporting platform, the 30-casing, the movable wheel of 31-, 32-nephropathy treatment monitoring section, 34-zone of alarm, the total monitoring section of 35-, 36-venous pressure table, 37-vein loop vascular clamp more than constitutes blood dialysis ultrafiltration of the present invention, hemodiafiltration, simple blood ultrafiltration, pure hemofiltration, hemodialysis perfusion, hemodialysis and pure hemofiltration carry out simultaneously, the another operation principle that hemodialysis and simple blood ultrafiltration carry out simultaneously and the critical piece of configuration state; Be blood dialysis ultrafiltration at part 5 places with dialyser merely; 5 places are hemodiafiltration with filter merely at part; At part 5 places merely with dialyser or filter and be simple blood ultrafiltration or pure hemofiltration without dialysis solution; 5 places are the hemodialysis perfusion with dialyser and blood perfusion device simultaneously at part; 5 places use hemodialyzer and transfusion filters simultaneously at part, and transfusion filters does not circulate, and dialysis solution is hemodialysis and pure hemofiltration carries out simultaneously; Use two hemodialyzers simultaneously at part 5 places, a circulation dialysis solution and another dialysis solution that do not circulate, promptly becoming hemodialysis and simple blood ultrafiltration carries out simultaneously; Adopt vascular puncture or intubate, patient's blood is led to ductus arteriosus 1 in body, under the driving of roller pump 2, arrive dialyser 5, after blood flows out from 5, arrive venous duct 6, continuing to move ahead arrives bubble trap 6a, by being back in patient's body from venous duct 6 behind the bubble trap 6a;

Dialysis fluid container

25a, 25b, dialysis solution among the 25c, through dialysis solution circulation fairlead 18a, 18b, 18c is at dialysis liquid pump 19a, or the attraction of 19b drives down, guide to that dialysis solution is heated and thermostat inlet tube 20, through heating and weighing temperature, heat and thermostat outlet 21 is discharged after dialysis solution circulation pipe 22 arrives dialyser arterial end dialysate holes from dialysis solution, behind dialyser, discharge from the vein end dialysate hole of dialyser, drain into dialysis solution circulation inlet tube 24a through

dialyser outlet

23,24b, 24c enters

dialysis fluid container

25a, 25b, 25c; Dialysis solution and the blood plasma memory thermostat 26 of heating is carrying out adding the monitoring of gentle weighing apparatus temperature continuously, dialysis fluid container monitor 28 is carrying out the monitoring of dialysis solution capacity or weight continuously, bubble trap and ultrasonic air monitor 6a are carrying out bubble monitoring in blood plane and the blood continuously, venous pressure table 36 is carrying out the venous pressure monitoring continuously, more than four monitoring systems in case when occurring surpassing the situation of threshold value, report to total monitoring section computer 35 by nephropathy treatment monitoring section 32, after total monitoring section computer 35 obtains information, by sending to give an order, indication nephropathy treatment monitoring section is handled automatically: when dialysate temperature was too high or too low: reported to the police immediately (1) immediately; (2) the indication dialysis solution thermostat 26 of heating stops to heat or heating; (3) indication dialysis

liquid pump

19a or 19b suspend rotation, and when dialysate temperature reached applicable threshold range, dialysis

liquid pump

19a, 19b recovered running.When venous pressure was too high or too low: reported to the police immediately (1); (2) indication roller pump 2 suspends running, when venous pressure returns in the scope of prescribed threshold, recovers roller pump 2 runnings.When having air or blood plane to descend obviously above threshold value among the bubble trap 6a: report to the police immediately (1); (2) roller pump suspends running immediately; (3) vein loop vascular clamp 37 is closed immediately, behind the air in having got rid of bubble trap 6a, removes and reports to the police, and roller pump recovers to rotate, and vein loop vascular clamp is open automatically.When the weight of dialysis fluid container or capacity surpassed or be lower than threshold value, reported to the police immediately (1); (2) suggestion content and processing method.

Figure 7 shows that the main program schematic diagram of computer operation of the present invention, after starting power supply, then start total monitoring section computer (35), according to treatment needs selective actuation nephropathy treatment monitoring section (32) and/or the liver treatment monitoring section (33) that declines, the working procedure of Xuan Zeing is simultaneously: after power supply and total monitoring section (35) start, then start (32), start roller pump (2), the blood pump drives blood circulation, starting the dialysis solution thermostat (26) of heating promptly begins dialysis solution and blood plasma memory are heated, after dialysate temperature reaches instructions for use, can start dialysis liquid pump (19a or 19b), after starting the dialysis liquid pump, then start dialysis fluid container monitor (28), monitoring the variation of dialysis solution capacity at any time, the capacity in the dialysis fluid container is too much or very few when exceeding the threshold definite value, report to the police immediately, and prompting corresponding contents and processing method; Monitoring the variation of venous pressure simultaneously,, reporting to the police immediately and close blood pump (2) if venous pressure is undesired and too high or too low when exceeding threshold value, venous pressure recover normal after, blood pump (2) recovers rotation; After the treatment beginning, monitoring treatment time always,, reporting to the police immediately and point out treatment time to arrive if treatment time arrives predetermined value; After starting roller pump (2), promptly start bubble trap and sonac (6a); Carrying out air monitering continuously, if the decline of air plane is arranged in bubble trap or in the blood of bubble trap, bubble is arranged, report to the police immediately, close blood pump (2) simultaneously, close vein loop vascular clamp (37), close blood plasma and feed back pump (11) and point out corresponding contents and processing method; After starting power supply, the dialysis solution thermostat (26) of heating is promptly carrying out dialysate temperature monitoring continuously, when being lower than the threshold definite value slightly, dialysate temperature heats at once, if a little higher than threshold definite value of dialysate temperature is promptly suspended and heated, dialysate temperature is too high or too low all reports to the police and shows corresponding contents and processing method; After starting power supply, optionally start plasma perfusion pump (9) and blood plasma feedback pump (11) according to the treatment type, venous pressure is crossed when having bubble or blood plane too low in the blood that is higher than threshold definite value and bubble trap, computer all instructs blood pump (2), plasma perfusion pump (9), blood plasma feeds back pump (11), and vein loop vascular clamp (37) is closed simultaneously, and alarm corresponding contents and processing method immediately.Treatment time then reports to the police immediately and points out the selection that finishes treatment or extended treatment time.

The present invention compares with present various types of artificial kidney machines and has the following advantages or good effect: (1) its function is many, can be used as the bicarbonate hemodialysis, the capacity monitoring, high-sodium dialysis, low sodium dialysis, blood dialysis ultrafiltration, hemodiafiltration, pure hemofiltration, simple blood ultrafiltration, the hemodialysis perfusion, hemoperfusion, blood dialysis ultrafiltration and simple filtration carry out simultaneously, and blood dialysis ultrafiltration and isolated ultrafiltration carry out simultaneously, separating plasma, a separating plasma displacement, dual separating plasma displacement, bioartificial liver's extracorporeal circulation of blood, the external plasma circulation of bioartificial liver, the biology artificial kidney extracorporeal circulation of blood; (2) volume is small and exquisite, is convenient to move use, and is not given treatment to the place and limits, and rescue can be used for paying a home visit.(3) low price, the function of this apparatus for supporting life one table apparatus is equivalent to three therapy apparatuss, and real price also has only present conventional hemodialysis (CHD) machine to add about 10% of water treatment machine, low cost, high-tech, high added value.(4) do not rely on the water source, power supply is not had specific (special) requirements, do not resemble the conventional hemo system of import and all want indispensable regulated power supply, increased user's input expense.(5) dialysis solution is done the repeated use of certain number of times in the effective time, and the consumption of at every turn treating dialysis solution has only 1/4 of conventional hemo system, has both saved the energy, does not reduce therapeutic effect again.(6) dialysis solution can be prepared voluntarily by prescription by medical institutions, and is easy to use.(7) the manufactured materials wide material sources of the basic element of character, manufacturing process is simple, implements easily.(8) the existing application of result practical experience in 8 years in earlier stage of the present invention has the model machine that directly can help to implement for implementing reference.

Embodiment:

Press accompanying drawing 1a, Fig. 1 b; Fig. 2 a, Fig. 2 b; Fig. 3 a, Fig. 3 b; Fig. 4 a, Fig. 4 b; Fig. 5 a, Fig. 5 b; Prepare the parts and the equipment of each several part shown in Fig. 6 a, Fig. 6 b,, mainly produce part, comprising: roller pump (2) with machined and/or mould manufacturing according to Fig. 1-shown in Figure 6; Dialysis liquid pump (19a, 19b); Plasma perfusion pump (9): dialysis liquid pump (19a) and plasma perfusion pump (9) as employing " convex " roller then the roller of two pumps be two sections with one, be the thick section roller that part is plasma perfusion pump (9) of roller, the thin segment of roller partly is the roller of dialysis liquid pump (19a); Blood plasma feeds back pump (11); Blood plasma memory (16) and dialysis solution and the blood plasma memory thermostat (26) of heating; Dialysis fluid container (25); Casing (31) etc.Concrete implementation step suggestion:

1, adopts one of non-" protruding " shape roller pump, arterio-venous catheter three covers, dialysis solution circulation pipe one cover, three of dialysis fluid containers, one of plasma separator, one of dialyser, one of filter, one of perfusion device, plasma separator one to two, each one of the biological liver cell reactor of polysulfone membrane or poly (ether sulfone) film, biological nephrocyte reactor, dialysis solution capacity (volume) is measured weighing apparatus coefficient one cover, and one of computer 386 or 486 mainboard are made casing with mould or machined, press shown in Fig. 1 a-Fig. 6 b, carrying out overall package respectively can become.

2, the blood plasma memory can adopt the disposable materials useds of macromolecule such as glass or medical plastic with Mould Machining, makes.The capacity 500-1500ml/ of blood plasma memory, shape can be circle.

3, dialysis fluid container can be with medical macromolecular materials manufacturings such as plastics, capacity 3000-10000ml/, may with 5000ml/ comparatively appropriate, volume is little, is convenient to nursing staff's operation.

4, venous pressure table monitoring coefficient, vein loop vascular clamp and actuating device, dialyser, the holder of liver, nephrocyte bioreactor is finished manufacturing with methods such as machineds respectively.

5, press the basic design of Fig. 7, finish (32), (33) manufacture and design with the computer command system of total monitoring section (35), and each system is organically connected.

Claims

1, a kind of medical apparatus for supporting life, it is characterized in that: twine by roller pump (2) by the pump line section of ductus arteriosus (1), link to each other with the arterial end of plasma separator (3a), the vein end of plasma separator (3a) is connected with blood connecting conduit (4), the other end of blood connecting conduit (4) is connected with the arterial end of hemodialyzer (5), the vein end of hemodialyzer (5) is connected with venous duct (6), bubble trap and sonac (6a) are arranged on venous duct (6), exhaustor (6b) and vein pressure pipe (6c), the vein pressure pipe is connected with venous pressure table (36); The lower end blood plasma tap of plasma separator (3a) is connected with an end of blood plasma drainage tube (7b), the other end of blood plasma drainage tube (7b) is connected with an end of plasma separator (3b), the other end of plasma separator (3b) is connected with blood plasma drainage tube (7a), and the other end of blood plasma drainage tube (7a) is connected with blood plasma memory (16); Be connected with blood plasma memory exhaustor (17) on the blood plasma memory, blood plasma pump line and feedback blood plasma pipe (8) one ends and blood plasma memory (16) join, and the other end twines by blood plasma feedback pump (11) and is connected with venous duct (6); Plasma perfusion arterial end pipe (10) one ends link to each other with blood plasma memory (16), twine and be connected with plasma perfusion device (12) by dialysis solution circulating pump (19a) other end, the other end of plasma perfusion device (12) is connected with plasma circulation connecting conduit (13), the other end of plasma circulation connecting conduit (13) is connected with liver, nephrocyte bioreactor (14), the other end of liver, nephrocyte bioreactor (14) is connected with plasma perfusion vein end pipe (15), and the other end of plasma perfusion vein end pipe (15) is connected with blood plasma memory (16); Dialysis solution circulation fairlead (18a, 18b, 18c) end inserts dialysis fluid container (25a respectively, 25b, 25c), through dialysis solution circulating pump and dialysis solution circulation pipe (19a, 19b) heat and thermostat inlet tube (20) is connected with dialysis solution, dialysis solution is heated and thermostat outlet (21) joins with hemodialyzer dialysis solution inlet tube (22), the dialysis solution inlet tube (22) of hemodialyzer is gone into nose end with the dialysis solution of hemodialyzer (5) and is connected, the dialysis solution outlet of hemodialyzer is connected with dialyser outlet (23), dialyser outlet (23) continues to extend and dialysis solution circulation inlet tube (24a, 24b, 24c) be connected dialysis solution circulation fairlead (18a, 18b, 18c) with dialysis solution circulation inlet tube (24a, 24b, 24c) all place dialysis fluid container (25a, 25b, 25c); Heat thermostat and medium (26) of dialysis solution and blood plasma memory is positioned at the top of dialysis fluid container (25a, 25b, 25c); Dialysis fluid container (25a, 25b, 25c) be positioned at dialysis fluid container platform (27) above, dialysis fluid container monitoring sensor (28) links with dialysis fluid container pick off supporting platform (29), and casing (30) is connected at four fulcrums in the below of casing (31) with movable wheel (31); Nephropathy treatment district (32) regulating liver-QI declines and gives treatment to the left and right sides that district (33) lays respectively at the apparatus for supporting life upper panel, zone of alarm (34) is positioned at (32) and (33) center upper portion, total computer monitoring district (35) is positioned at the below of zone of alarm (34), venous pressure table (36) is positioned at the left side in nephropathy treatment district (32), venous duct loop vascular clamp (37) is positioned at the below of venous pressure table (36), constitutes apparatus for supporting life jointly.

2, apparatus for supporting life according to claim 1, its feature also is: blood plasma memory (16) is the container of being made by transparent glass or disposable medical macromolecular materials, its peristome adopts medical grade silicon rubber or medical macromolecular materials to make the gag of a band periphery, central part design at gag has blood plasma drainage tube and exhaustor, the capacity of blood plasma memory (16) is 500～1500ml, and the manufactured materials of blood plasma memory (16) all is high temperature-resistant disinfected or is disposable medical macromolecular materials.

3, apparatus for supporting life according to claim 1, its feature also is: dialysis liquid pump (19) can be " protruding " type roller pump, by the thin segment of " protruding " type roller pump, spreading dialysis solution pump line drives the dialysis solution circulation; By thick section spreading plasma perfusion pump line of " protruding " type roller pump, make plasma perfusion device (12) regulating liver-QI or nephrocyte bioreactor (14) carry out plasma circulation synchronously.

4, apparatus for supporting life according to claim 1, its feature also is: dialysis liquid pump (19b) can be a centrifugal pump, and the pump head part manufactured materials of centrifugal pump can be a rustless steel, nylon, plastics, silicone rubber or other macromolecular material.

5, apparatus for supporting life according to claim 1, its feature also is: the manufactured materials of liver, nephrocyte bioreactor (14) can be a polysulfone membrane, polyacrylonitrile film, macromolecular materials such as poly (ether sulfone) film; Liver, the used biological cell of nephrocyte bioreactor (14) can be the alive liver cells of former generation animal (pig), and the kidney living cells also can be liver, the nephrocyte through cultivating; Can be former generation liver, nephrocyte suspension, also can be liver, the nephrocyte suspension through cultivating; Also can be to adopt the liver of former generation of living or cultivation, nephrocyte medical biological cell alite paste to adhere to the outer wall of the medical high polymer hollow fibre pipe of bioreactor, make the alive liver cell that is fixed in hollow fibre pipe outer wall, nephrocyte alive, the biological action of performance hepatocyte, nephrocyte.