CN112167638A - Plant antioxidant formula and preparation method - Google Patents
Plant antioxidant formula and preparation method Download PDFInfo
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- CN112167638A CN112167638A CN202010601267.1A CN202010601267A CN112167638A CN 112167638 A CN112167638 A CN 112167638A CN 202010601267 A CN202010601267 A CN 202010601267A CN 112167638 A CN112167638 A CN 112167638A
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- 239000003963 antioxidant agent Substances 0.000 title claims abstract description 32
- 238000002360 preparation method Methods 0.000 title claims abstract description 28
- 238000009472 formulation Methods 0.000 title claims description 7
- 239000002994 raw material Substances 0.000 claims abstract description 24
- 241000196324 Embryophyta Species 0.000 claims abstract description 22
- 229940087603 grape seed extract Drugs 0.000 claims abstract description 18
- 235000002532 grape seed extract Nutrition 0.000 claims abstract description 18
- 239000000203 mixture Substances 0.000 claims abstract description 18
- 239000001717 vitis vinifera seed extract Substances 0.000 claims abstract description 18
- BAWFJGJZGIEFAR-NNYOXOHSSA-N NAD zwitterion Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-N 0.000 claims abstract description 15
- 229950006238 nadide Drugs 0.000 claims abstract description 15
- 238000001035 drying Methods 0.000 claims abstract description 13
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 claims abstract description 11
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- 238000003795 desorption Methods 0.000 claims description 16
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- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 claims description 12
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 12
- 239000011347 resin Substances 0.000 claims description 12
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- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 claims description 8
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims description 8
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- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 6
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- JLEBZPBDRKPWTD-TURQNECASA-O N-ribosylnicotinamide Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](CO)O2)O)=C1 JLEBZPBDRKPWTD-TURQNECASA-O 0.000 claims description 4
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- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 claims description 4
- 229960005305 adenosine Drugs 0.000 claims description 4
- PPQRONHOSHZGFQ-LMVFSUKVSA-N aldehydo-D-ribose 5-phosphate Chemical compound OP(=O)(O)OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PPQRONHOSHZGFQ-LMVFSUKVSA-N 0.000 claims description 4
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 claims description 4
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- YVBGRQLITPHVOP-UHFFFAOYSA-L disodium;[hydroxy-[hydroxy(oxido)phosphoryl]oxyphosphoryl] hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])(=O)OP(O)(=O)OP(O)([O-])=O YVBGRQLITPHVOP-UHFFFAOYSA-L 0.000 claims description 4
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- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims description 4
- DAYLJWODMCOQEW-TURQNECASA-O NMN(+) Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP(O)(O)=O)O2)O)=C1 DAYLJWODMCOQEW-TURQNECASA-O 0.000 claims 5
- DAYLJWODMCOQEW-TURQNECASA-N NMN zwitterion Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP(O)([O-])=O)O2)O)=C1 DAYLJWODMCOQEW-TURQNECASA-N 0.000 abstract description 25
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- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 abstract description 12
- 229930003427 Vitamin E Natural products 0.000 abstract description 6
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 abstract description 6
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- 238000010298 pulverizing process Methods 0.000 abstract 1
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 description 4
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 description 3
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
- A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Inorganic Chemistry (AREA)
- Botany (AREA)
- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a plant antioxidant formula and a preparation method thereof, relating to the technical field of health-care drinks; in order to solve the problem of poor antioxidant effect of natural vitamin E; a plant antioxidant formula comprises the following components in parts by weight: 150 parts of nicotinamide mononucleotide and 60 parts of nicotinamide adenine dinucleotide; a preparation method of a plant antioxidant comprises the following steps: drying, pulverizing, and sieving with 60 mesh sieve to obtain uniform raw material granule, wherein the raw material is kept dry. The grape seed extract is added, the grape seed extract has the effects of calming, resisting convulsion and reducing blood pressure, NMN is often needed in an enzyme metabolic pathway which plays a physiological role in a human body, the NMN in the composition can enhance the physiological function of each component, all the components play a synergistic role, the climacteric symptoms are improved safely and comprehensively without side effects, and the cell growth is promoted.
Description
Technical Field
The invention relates to the technical field of health-care drinks, in particular to a plant antioxidant formula and a preparation method thereof.
Background
Antioxidants can be classified into two types, synthetic antioxidants such as BHA (butyl hydroxy anisole), BHT (dibutyl hydroxy toluene), PG (propyl gallate) and the like, which are used in many food products to prevent rancidity and oxidation of fats and oils, depending on the source. Because potential harm to health caused by delay in synthesizing the antioxidant is caused, for example, BHA is carcinogenic in animal experiments, the antioxidant mainly comprises vitamin C and vitamin E at present, the extraction cost of vitamin C plants is too high, and the antioxidant is mainly artificially synthesized at present; it has been found that natural vitamin E has an unsatisfactory antioxidant effect on vegetable oils, and it is a hot point of research to find antioxidant substances from natural plants, which have various functions and are widely used in processed foods as food additives, and also have been shown that antioxidant substances have an effect of reducing diseases such as cancer, cardiovascular diseases and stroke.
Through search, the Chinese patent with the application number of CN92108622.9 discloses an antioxidant for a beauty skin care preparation, which comprises phyllanthus emblica powder, tea polyphenol and vitamin E in a certain ratio; the emblic leafflower fruit powder and the tea polyphenol are excellent scavengers of free radicals and active oxygen, are compounded with vitamin E and are mutually synergistic to form a totipotent scavenger of the free radicals and the active oxygen and a blocker of lipid peroxidation. The antioxidant for cosmetic skin care preparations in the above patents has the following disadvantages: it has been found that natural vitamin E is not ideal for the antioxidant effect of vegetable oils.
Disclosure of Invention
The invention aims to solve the defects in the prior art and provides a plant antioxidant formula and a preparation method thereof.
In order to achieve the purpose, the invention adopts the following technical scheme:
a plant antioxidant formula comprises the following components in parts by weight: 150 parts of nicotinamide mononucleotide, 60 parts of nicotinamide adenine dinucleotide, 25 parts of grape seed extract, 25 parts of ginsenoside, 40 parts of magnesium stearate, 5 parts of silicon dioxide and 150 parts of hydroxypropyl methylcellulose.
Preferably: the preparation method of the nicotinamide mononucleotide comprises the following steps:
s1: adding a substrate solution to a reaction kettle: 30ml ATP, 30ml xylose, 20ml MgCl2, 10ml KC1 and l00ml Tris-HCl buffer, adjusting the pH of the substrate solution to 7.5-8.0;
s2: the following catalytic enzymes were then added: 6g/L of ribose phosphate pyrophosphate kinase substrate solution, 10g/L of ribose-5-phosphate isomerase substrate solution, llg g/L of ribulose-3-phosphate isomerase substrate solution, 10g/L of xylulokinase substrate solution and 10g/L of xylose isomerase substrate solution are stirred uniformly and then react;
s3: continuously stirring in the reaction process, wherein the stirring speed is 50 r/min, the reaction temperature is controlled to be 35 ℃, the PH value is maintained to be 7.5-8.0, and the reaction liquid is separated after the reaction is carried out for 4 hours;
s4: feeding the reaction solution into another reaction kettle, adding 60ml of nicotinamide, 30ml of ZnCl2, Tris-HCl buffer solution of L00ml and 15g/L substrate solution of nicotinamide phosphoribosyl transferase into the reaction solution, and continuing the reaction after uniformly stirring;
s5: continuously stirring in the reaction process, wherein the stirring speed is 50 r/min, the reaction temperature is controlled to be 35 ℃, the p value is maintained to be 7.5-8.0, and then reacting for 4h to obtain a crude nicotinamide mononucleotide product solution;
s6: finally, the finished product of nicotinamide mononucleotide with the purity of 99 percent is obtained after filtration, purification and drying.
Preferably: the preparation method of the nicotinamide adenine dinucleotide comprises the following steps:
s11: adding 10mL of Tris-HCl buffer solution into a 20mL three-neck flask, wherein the pH value is 7.5;
s12: sequentially adding 50mg of nicotinamide riboside, 55mg of adenosine disodium triphosphate, 10mg of nicotinamide riboside kinase and 20ml of magnesium chloride, and stirring at the temperature of 37 ℃ and 200rpm for reaction;
s13: monitoring the conversion rate of the reaction by using a liquid chromatography-mass spectrometry combination, detecting that the adenosine triphosphate is completely consumed after the reaction is carried out for 6 hours, and stopping the reaction;
s14: and further filtering, absorbing by HZ-818 type macroporous resin, freeze-drying, and recrystallizing by ethanol and water to obtain the oxidized coenzyme I product with the purity of 99 percent.
Preferably: the preparation method of the grape seed extract comprises the following steps:
s21: weighing 1000g of grape seeds as raw materials, adding 4 times of water, stirring and extracting at 100 ℃ for 3 times, each time for 2 hours, and filtering with 400-mesh filter cloth to obtain filtrate;
s22: adsorbing the filtrate with 1100ml of DM21 resin at an adsorption flow rate of 1 BV/h;
s23: 2BV of water is used for impurity washing, 70 percent ethanol is used for desorption, the desorption flow rate is 1BV/h, and about 1.5BV of desorption solution is collected;
s24: passing the desorption solution through 500mL of LSK11 resin, collecting eluate, and concentrating under-0.085 MPa at 45 deg.C under reduced pressure to obtain Baume degree of 15;
s25: spraying the concentrated solution at inlet temperature of 180 deg.C and outlet temperature of 85 deg.C to obtain grape seed extract with purity of 95%.
Preferably: the preparation method of the ginsenoside comprises the following steps:
s31: taking 30 g of crushed ginseng, adding eight times of 50% ethanol, and carrying out ultrasonic extraction for 2 h;
s32: filtering, sequentially adding 50% ethanol into the residue, and performing ultrasonic extraction for 1 h;
s33: and (4) carrying out suction filtration, combining the two filtrates, and recovering ethanol under reduced pressure until the filtrate is 100ml to obtain a product with the purity of 10%.
Preferably: replacing the components in the weight ratio by the following components in the weight ratio: 130 parts of nicotinamide mononucleotide, 50 parts of nicotinamide adenine dinucleotide, 45 parts of grape seed extract, 35 parts of ginsenoside, 50 parts of magnesium stearate, 5 parts of silicon dioxide and 130 parts of hydroxypropyl methylcellulose.
A preparation method of a plant antioxidant comprises the following steps:
s111: drying, crushing and sieving the raw materials with a 60-mesh sieve to obtain uniform raw material particles, wherein the raw materials are kept dry;
s112: weighing the raw materials according to the weight part ratio, mixing the weighed raw materials and uniformly stirring to obtain a composition;
s113: granulating the composition in a granulator, and finishing after drying;
s114: putting the granules into a tablet press, adjusting parameters of the tablet press, and performing tabletting, wherein the theoretical tablet weight is 555 mg;
s115: finally, performing film coating, inspection and packaging.
The invention has the beneficial effects that:
1. the grape seed extract has the effects of tranquilizing, resisting convulsion and reducing blood pressure, NMN is usually needed in an enzyme metabolic pathway which plays a physiological role in a human body, the NMN in the composition can enhance the physiological function of each component, all the components play a synergistic role, the climacteric symptoms are improved safely and comprehensively without side effects, and the cell growth is promoted.
And 2, NMN has the effects of repairing the DNA damaged by space radiation and recovering the loss of skeletal muscle under weightlessness, the NMN has the effects of enhancing the key enzyme activity of each component in the metabolic process and increasing the cell capacity of the NMN, and the anti-oxidation effect is obvious.
3. The raw materials are respectively and independently prepared and then mixed together in proportion to prepare the tablet, so that the tablet is convenient to take, the preparation process flow of the antioxidant is simple, the process time is short, no by-product is generated, the production cost is low, and the large-scale production is easy to realize.
Drawings
Fig. 1 is a flow chart of a plant antioxidant formula and a preparation method thereof provided by the invention.
Detailed Description
The technical solution of the present patent will be described in further detail with reference to the following embodiments.
Reference will now be made in detail to embodiments of the present patent, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the drawings are exemplary only for the purpose of explaining the present patent and are not to be construed as limiting the present patent.
In the description of this patent, it is to be understood that the terms "center," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like are used in the orientations and positional relationships indicated in the drawings for the convenience of describing the patent and for the simplicity of description, and are not intended to indicate or imply that the referenced devices or elements must have a particular orientation, be constructed and operated in a particular orientation, and are not to be considered limiting of the patent.
In the description of this patent, it is noted that unless otherwise specifically stated or limited, the terms "mounted," "connected," and "disposed" are to be construed broadly and can include, for example, fixedly connected, disposed, detachably connected, disposed, or integrally connected and disposed. The specific meaning of the above terms in this patent may be understood by those of ordinary skill in the art as appropriate.
Example 1:
a plant antioxidant formula is shown in figure 1 and comprises the following components in percentage by weight: 150 parts of nicotinamide mononucleotide, 60 parts of nicotinamide adenine dinucleotide, 25 parts of grape seed extract, 25 parts of ginsenoside, 40 parts of magnesium stearate, 5 parts of silicon dioxide and 150 parts of hydroxypropyl methylcellulose.
The preparation method of the nicotinamide mononucleotide comprises the following steps:
s1: adding a substrate solution to a reaction kettle: 30ml ATP, 30ml xylose, 20ml MgCl2, 10ml KC1 and l00ml Tris-HCl buffer, adjusting the pH of the substrate solution to 7.5-8.0;
s2: the following catalytic enzymes were then added: 6g/L of ribose phosphate pyrophosphate kinase substrate solution, 10g/L of ribose-5-phosphate isomerase substrate solution, llg g/L of ribulose-3-phosphate isomerase substrate solution, 10g/L of xylulokinase substrate solution and 10g/L of xylose isomerase substrate solution are stirred uniformly and then react;
s3: continuously stirring in the reaction process, wherein the stirring speed is 50 r/min, the reaction temperature is controlled to be 35 ℃, the PH value is maintained to be 7.5-8.0, and the reaction liquid is separated after the reaction is carried out for 4 hours;
s4: feeding the reaction solution into another reaction kettle, adding 60ml of nicotinamide, 30ml of ZnCl2, Tris-HCl buffer solution of L00ml and 15g/L substrate solution of nicotinamide phosphoribosyl transferase into the reaction solution, and continuing the reaction after uniformly stirring;
s5: continuously stirring in the reaction process, wherein the stirring speed is 50 r/min, the reaction temperature is controlled to be 35 ℃, the p value is maintained to be 7.5-8.0, and then reacting for 4h to obtain a crude nicotinamide mononucleotide product solution;
s6: finally, the finished product of nicotinamide mononucleotide with the purity of 99 percent is obtained after filtration, purification and drying.
The preparation method of the nicotinamide adenine dinucleotide comprises the following steps:
s11: adding 10mL of Tris-HCl buffer solution into a 20mL three-neck flask, wherein the pH value is 7.5;
s12: sequentially adding 50mg of nicotinamide riboside, 55mg of adenosine disodium triphosphate, 10mg of nicotinamide riboside kinase and 20ml of magnesium chloride, and stirring at the temperature of 37 ℃ and 200rpm for reaction;
s13: monitoring the conversion rate of the reaction by using a liquid chromatography-mass spectrometry combination, detecting that the adenosine triphosphate is completely consumed after the reaction is carried out for 6 hours, and stopping the reaction;
s14: and further filtering, absorbing by HZ-818 type macroporous resin, freeze-drying, and recrystallizing by ethanol and water to obtain the oxidized coenzyme I product with the purity of 99 percent.
The preparation method of the grape seed extract comprises the following steps:
s21: weighing 1000g of grape seeds as raw materials, adding 4 times of water, stirring and extracting at 100 ℃ for 3 times, each time for 2 hours, and filtering with 400-mesh filter cloth to obtain filtrate;
s22: adsorbing the filtrate with 1100ml of DM21 resin at an adsorption flow rate of 1 BV/h;
s23: 2BV of water is used for impurity washing, 70 percent ethanol is used for desorption, the desorption flow rate is 1BV/h, and about 1.5BV of desorption solution is collected;
s24: passing the desorption solution through 500mL of LSK11 resin, collecting eluate, and concentrating under-0.085 MPa at 45 deg.C under reduced pressure to obtain Baume degree of 15;
s25: spraying the concentrated solution at inlet temperature of 180 deg.C and outlet temperature of 85 deg.C to obtain grape seed extract with purity of 95%.
The preparation method of the ginsenoside comprises the following steps:
s31: taking 30 g of crushed ginseng, adding eight times of 50% ethanol, and carrying out ultrasonic extraction for 2 h;
s32: filtering, sequentially adding 50% ethanol into the residue, and performing ultrasonic extraction for 1 h;
s33: and (4) carrying out suction filtration, combining the two filtrates, and recovering ethanol under reduced pressure until the filtrate is 100ml to obtain a product with the purity of 10%.
A preparation method of a plant antioxidant comprises the following steps:
s111: drying, crushing and sieving the raw materials with a 60-mesh sieve to obtain uniform raw material particles, wherein the raw materials are kept dry;
s112: weighing the raw materials according to the weight part ratio, mixing the weighed raw materials and uniformly stirring to obtain a composition;
s113: granulating the composition in a granulator, and finishing after drying;
s114: putting the granules into a tablet press, adjusting parameters of the tablet press, and performing tabletting, wherein the theoretical tablet weight is 555 mg;
s115: finally, performing film coating, inspection and packaging.
When the composition is used, the raw materials are respectively and independently prepared, and then are mixed together in proportion to prepare a tablet, so that the composition is convenient to take, the grape seed extract has the effects of calming, resisting convulsion and reducing blood pressure, the enzyme metabolic pathway exerting physiological action in a human body usually needs NMN, the NMN in the composition can enhance the physiological function of each component, repair DNA damaged by space radiation and restore loss of skeletal muscle under weightlessness, the NMN has the effects of enhancing the key enzyme activity of each component in the metabolic process and increasing the cell capacity of the NMN, the synergistic effect of all the components is exerted, the climacteric symptoms are comprehensively improved safely without side effects, the preparation process flow of the antioxidant is simple, the process time is short, no by-product is generated, the production cost is low, and the large-scale production is easy to realize.
Example 2:
a plant antioxidant formula is shown in figure 1 and comprises the following components in percentage by weight: 130 parts of nicotinamide mononucleotide, 50 parts of nicotinamide adenine dinucleotide, 45 parts of grape seed extract, 35 parts of ginsenoside, 50 parts of magnesium stearate, 5 parts of silicon dioxide and 130 parts of hydroxypropyl methylcellulose.
The preparation method of the nicotinamide mononucleotide comprises the following steps:
s1: adding a substrate solution to a reaction kettle: 30ml ATP, 30ml xylose, 20ml MgCl2, 10ml KC1 and l00ml Tris-HCl buffer, adjusting the pH of the substrate solution to 7.5-8.0;
s2: the following catalytic enzymes were then added: 6g/L of ribose phosphate pyrophosphate kinase substrate solution, 10g/L of ribose-5-phosphate isomerase substrate solution, llg g/L of ribulose-3-phosphate isomerase substrate solution, 10g/L of xylulokinase substrate solution and 10g/L of xylose isomerase substrate solution are stirred uniformly and then react;
s3: continuously stirring in the reaction process, wherein the stirring speed is 50 r/min, the reaction temperature is controlled to be 35 ℃, the PH value is maintained to be 7.5-8.0, and the reaction liquid is separated after the reaction is carried out for 4 hours;
s4: feeding the reaction solution into another reaction kettle, adding 60ml of nicotinamide, 30ml of ZnCl2, Tris-HCl buffer solution of L00ml and 15g/L substrate solution of nicotinamide phosphoribosyl transferase into the reaction solution, and continuing the reaction after uniformly stirring;
s5: continuously stirring in the reaction process, wherein the stirring speed is 50 r/min, the reaction temperature is controlled to be 35 ℃, the p value is maintained to be 7.5-8.0, and then reacting for 4h to obtain a crude nicotinamide mononucleotide product solution;
s6: finally, the finished product of nicotinamide mononucleotide with the purity of 99 percent is obtained after filtration, purification and drying.
The preparation method of the nicotinamide adenine dinucleotide comprises the following steps:
s11: adding 10mL of Tris-HCl buffer solution into a 20mL three-neck flask, wherein the pH value is 7.5;
s12: sequentially adding 50mg of nicotinamide riboside, 55mg of adenosine disodium triphosphate, 10mg of nicotinamide riboside kinase and 20ml of magnesium chloride, and stirring at the temperature of 37 ℃ and 200rpm for reaction;
s13: monitoring the conversion rate of the reaction by using a liquid chromatography-mass spectrometry combination, detecting that the adenosine triphosphate is completely consumed after the reaction is carried out for 6 hours, and stopping the reaction;
s14: and further filtering, absorbing by HZ-818 type macroporous resin, freeze-drying, and recrystallizing by ethanol and water to obtain the oxidized coenzyme I product with the purity of 99 percent.
The preparation method of the grape seed extract comprises the following steps:
s21: weighing 1000g of grape seeds as raw materials, adding 4 times of water, stirring and extracting at 100 ℃ for 3 times, each time for 2 hours, and filtering with 400-mesh filter cloth to obtain filtrate;
s22: adsorbing the filtrate with 1100ml of DM21 resin at an adsorption flow rate of 1 BV/h;
s23: 2BV of water is used for impurity washing, 70 percent ethanol is used for desorption, the desorption flow rate is 1BV/h, and about 1.5BV of desorption solution is collected;
s24: passing the desorption solution through 500mL of LSK11 resin, collecting eluate, and concentrating under-0.085 MPa at 45 deg.C under reduced pressure to obtain Baume degree of 15;
s25: spraying the concentrated solution at inlet temperature of 180 deg.C and outlet temperature of 85 deg.C to obtain grape seed extract with purity of 95%.
The preparation method of the ginsenoside comprises the following steps:
s31: taking 30 g of crushed ginseng, adding eight times of 50% ethanol, and carrying out ultrasonic extraction for 2 h;
s32: filtering, sequentially adding 50% ethanol into the residue, and performing ultrasonic extraction for 1 h;
s33: and (4) carrying out suction filtration, combining the two filtrates, and recovering ethanol under reduced pressure until the filtrate is 100ml to obtain a product with the purity of 10%.
A preparation method of a plant antioxidant comprises the following steps:
s111: drying, crushing and sieving the raw materials with a 60-mesh sieve to obtain uniform raw material particles, wherein the raw materials are kept dry;
s112: weighing the raw materials according to the weight part ratio, mixing the weighed raw materials and uniformly stirring to obtain a composition;
s113: granulating the composition in a granulator, and finishing after drying;
s114: putting the granules into a tablet press, adjusting parameters of the tablet press, and performing tabletting, wherein the theoretical tablet weight is 555 mg;
s115: finally, performing film coating, inspection and packaging.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (7)
1. The plant antioxidant formula is characterized by comprising the following components in parts by weight: 150 parts of nicotinamide mononucleotide, 60 parts of nicotinamide adenine dinucleotide, 25 parts of grape seed extract, 25 parts of ginsenoside, 40 parts of magnesium stearate, 5 parts of silicon dioxide and 150 parts of hydroxypropyl methylcellulose.
2. The plant antioxidant formulation of claim 1, wherein said nicotinamide mononucleotide is prepared by a process comprising the steps of:
s1: adding a substrate solution to a reaction kettle: 30ml ATP, 30ml xylose, 20ml MgCl2, 10ml KC1 and l00ml Tris-HCl buffer, adjusting the pH of the substrate solution to 7.5-8.0;
s2: the following catalytic enzymes were then added: 6g/L of ribose phosphate pyrophosphate kinase substrate solution, 10g/L of ribose-5-phosphate isomerase substrate solution, llg g/L of ribulose-3-phosphate isomerase substrate solution, 10g/L of xylulokinase substrate solution and 10g/L of xylose isomerase substrate solution are stirred uniformly and then react;
s3: continuously stirring in the reaction process, wherein the stirring speed is 50 r/min, the reaction temperature is controlled to be 35 ℃, the PH value is maintained to be 7.5-8.0, and the reaction liquid is separated after the reaction is carried out for 4 hours;
s4: feeding the reaction solution into another reaction kettle, adding 60ml of nicotinamide, 30ml of ZnCl2, Tris-HCl buffer solution of L00ml and 15g/L substrate solution of nicotinamide phosphoribosyl transferase into the reaction solution, and continuing the reaction after uniformly stirring;
s5: continuously stirring in the reaction process, wherein the stirring speed is 50 r/min, the reaction temperature is controlled to be 35 ℃, the p value is maintained to be 7.5-8.0, and then reacting for 4h to obtain a crude nicotinamide mononucleotide product solution;
s6: finally, the finished product of nicotinamide mononucleotide with the purity of 99 percent is obtained after filtration, purification and drying.
3. The plant antioxidant formulation of claim 2, wherein said nicotinamide adenine dinucleotide is prepared by a process comprising the steps of:
s11: adding 10mL of Tris-HCl buffer solution into a 20mL three-neck flask, wherein the pH value is 7.5;
s12: sequentially adding 50mg of nicotinamide riboside, 55mg of adenosine disodium triphosphate, 10mg of nicotinamide riboside kinase and 20ml of magnesium chloride, and stirring at the temperature of 37 ℃ and 200rpm for reaction;
s13: monitoring the conversion rate of the reaction by using a liquid chromatography-mass spectrometry combination, detecting that the adenosine triphosphate is completely consumed after the reaction is carried out for 6 hours, and stopping the reaction;
s14: and further filtering, absorbing by HZ-818 type macroporous resin, freeze-drying, and recrystallizing by ethanol and water to obtain the oxidized coenzyme I product with the purity of 99 percent.
4. The plant antioxidant formulation of claim 3, wherein said grape seed extract is prepared by a process comprising the steps of:
s21: weighing 1000g of grape seeds as raw materials, adding 4 times of water, stirring and extracting at 100 ℃ for 3 times, each time for 2 hours, and filtering with 400-mesh filter cloth to obtain filtrate;
s22: adsorbing the filtrate with 1100ml of DM21 resin at an adsorption flow rate of 1 BV/h;
s23: 2BV of water is used for impurity washing, 70 percent ethanol is used for desorption, the desorption flow rate is 1BV/h, and about 1.5BV of desorption solution is collected;
s24: passing the desorption solution through 500mL of LSK11 resin, collecting eluate, and concentrating under-0.085 MPa at 45 deg.C under reduced pressure to obtain Baume degree of 15;
s25: spraying the concentrated solution at inlet temperature of 180 deg.C and outlet temperature of 85 deg.C to obtain grape seed extract with purity of 95%.
5. The plant antioxidant formulation of claim 4, wherein the preparation of ginsenosides comprises the steps of:
s31: taking 30 g of crushed ginseng, adding eight times of 50% ethanol, and carrying out ultrasonic extraction for 2 h;
s32: filtering, sequentially adding 50% ethanol into the residue, and performing ultrasonic extraction for 1 h;
s33: and (4) carrying out suction filtration, combining the two filtrates, and recovering ethanol under reduced pressure until the filtrate is 100ml to obtain a product with the purity of 10%.
6. The plant antioxidant formulation according to claim 1, wherein the following components are substituted by the following components in weight ratio: 130 parts of nicotinamide mononucleotide, 50 parts of nicotinamide adenine dinucleotide, 45 parts of grape seed extract, 35 parts of ginsenoside, 50 parts of magnesium stearate, 5 parts of silicon dioxide and 130 parts of hydroxypropyl methylcellulose.
7. A preparation method of a plant antioxidant is characterized by comprising the following steps:
s111: drying, crushing and sieving the raw materials with a 60-mesh sieve to obtain uniform raw material particles, wherein the raw materials are kept dry;
s112: weighing the raw materials according to the weight part ratio, mixing the weighed raw materials and uniformly stirring to obtain a composition;
s113: granulating the composition in a granulator, and finishing after drying;
s114: putting the granules into a tablet press, adjusting parameters of the tablet press, and performing tabletting, wherein the theoretical tablet weight is 555 mg;
s115: finally, performing film coating, inspection and packaging.
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