CN112156039A

CN112156039A - Depilatory preparation and preparation method thereof

Info

Publication number: CN112156039A
Application number: CN202011253457.5A
Authority: CN
Inventors: 何梦琳
Original assignee: Guangzhou Dove Cosmetics Co ltd
Current assignee: Guangzhou Dove Cosmetics Co ltd
Priority date: 2020-11-11
Filing date: 2020-11-11
Publication date: 2021-01-01

Abstract

The invention discloses a depilatory preparation and a preparation method thereof, belonging to the technical field of skin care products and comprising a phase A, a phase B, a phase C and a phase D; wherein the phase A comprises the following substances: squalane, dimethicone, ceteareth-2, ceteareth-21, olive (OLEA EUROPAEA) fruit oil, tocopherol acetate, cetearyl alcohol, myristic acid; phase B comprises the following substances: butanediol, glycerol, hydroxyethyl cellulose, xanthan gum, allantoin, folium Pini extract, and deionized water; phase C comprises the following substances: calcium thioglycolate, calcium hydroxide; phase D comprises the following substances: bisabolol; heating in an oil phase pot, dissolving, keeping the temperature, mixing and stirring in an emulsifying pot, mixing and stirring, vacuumizing, homogenizing, cooling, and filling to obtain the finished product. The depilatory preparation obtained by the invention can be used for depilating gently, has a thorough depilatory effect and does not leave hair.

Description

Depilatory preparation and preparation method thereof

Technical Field

The invention relates to the technical field of skin care products, and particularly belongs to a depilatory preparation and a preparation method thereof.

Background

With the improvement of the living quality of people, people pay more and more attention to the beauty and care of skin, and some hairs on the skin of the body, such as hand and foot hair, armpit hair and the like, are exposed after being worn in summer, so that the beauty is easily influenced, especially for women who love beauty, and then the depilatory related preparation is produced at the same time. However, the existing depilatory preparation has poor depilatory effect, and a large amount of hair is always left, so that the depilation is not complete.

In addition, the existing depilatory preparation adds a plurality of irritant components for rapidly depilating, so that the skin becomes red and swollen after depilating, and even becomes allergic. Such as the addition of thioglycolic acid, which is more corrosive; ammonium thioglycollate is not alkali-resistant, has a large taste and is not suitable for being added into depilatory cream; sodium/potassium thioglycollate is not suitable for being added into the depilatory cream because the metal ion activity is too strong and the irritation is strong; calcium thioglycolate is more inert and milder than metal, but has relatively general depilatory effect as a depilatory preparation, and can cause irritation or poor depilatory effect when used under poor control.

In addition, the existing depilatory preparation grows hair at the depilatory position soon after depilation, and newly grown hair is easily rougher and thicker, so that a user needs to depilate again soon, and the newly grown hair is thicker when the use frequency is more frequent, so that the use amount of the depilatory preparation needs to be increased, the depilation is carried out more frequently, the depilatory interval is shorter and shorter, and the vicious circle is caused, so that the user is more worried.

Disclosure of Invention

Aiming at the defects and shortcomings in the background technology, the invention provides the depilatory preparation, which can carry out depilation mildly, has thorough depilatory effect and can not leave hair.

The second purpose of the invention is to provide a preparation method of the depilatory preparation, which can effectively promote the full mixing and reaction among all the substances, promote the exertion of the synergistic effect of all the substances and reduce the irritation, so that the depilatory preparation prepared by the preparation method has more thorough depilatory effect, is safe and has no stimulation.

In order to realize the purpose, the invention adopts the following technical scheme to realize the purpose:

a depilatory formulation comprising phase A, phase B, phase C and phase D;

wherein the phase A comprises the following substances: squalane, dimethicone, ceteareth-2, ceteareth-21, olive (OLEA EUROPAEA) fruit oil, tocopherol acetate, cetearyl alcohol, myristic acid;

phase B comprises the following substances: butanediol, glycerol, hydroxyethyl cellulose, xanthan gum, allantoin, folium Pini extract, and deionized water;

phase C comprises the following substances: calcium thioglycolate, calcium hydroxide;

phase D comprises the following substances: bisabolol.

Further measures taken are: the substances in the phase A account for the following corresponding weight percentages of the whole: 1.0 to 5.0 percent of squalane, 1.0 to 5.0 percent of polydimethylsiloxane, 21.0 to 5.0 percent of ceteareth-21, 5 to 3.0 percent of ceteareth-210, 5 to 3.0 percent of olive (OLEA EUROPAEA) fruit oil, 0.1 to 0.8 percent of tocopherol acetate, 0.5 to 3.0 percent of cetearyl alcohol and 0.5 to 1.0 percent of myristic acid;

the substances in the phase B account for the following corresponding weight percentages of the whole: 2.0 to 6.0 percent of butanediol, 3.0 to 8.0 percent of glycerol, 0.1 to 0.5 percent of hydroxyethyl cellulose, 0.1 to 0.5 percent of xanthan gum, 0.1 to 0.2 percent of allantoin and 0.2 to 0.8 percent of pine needle extract;

the substances in the phase C account for the following corresponding weight percentages of the whole: 2.0-4.0% of calcium thioglycolate and 0.5-1.2% of calcium hydroxide;

the corresponding weight percentages of the substances in the D phase in the whole are as follows: 0.1-0.5% of bisabolol;

the rest is added to 100 percent by deionized water in the B phase.

Further measures taken are: the substances in the phase A account for the following corresponding weight percentages of the whole: squalane 2.0-4.0%, polydimethylsiloxane 2.0-4.0%, ceteareth-22.0-4.0%, ceteareth-211.0-2.5%, olive (OLEA EUROPAEA) fruit oil 0.5-3.0%, tocopherol acetate 0.1-0.8%, cetearyl alcohol 1.0-2.5%, myristic acid 0.3-0.6%;

the substances in the phase B account for the following corresponding weight percentages of the whole: 3.0 to 5.0 percent of butanediol, 4.0 to 6.0 percent of glycerol, 0.2 to 0.4 percent of hydroxyethyl cellulose, 0.2 to 0.4 percent of xanthan gum, 0.1 to 0.2 percent of allantoin and 0.3 to 0.8 percent of pine needle extract;

the substances in the phase C account for the following corresponding weight percentages of the whole: 3.0-3.5% of calcium thioglycolate and 0.6-1.0% of calcium hydroxide;

the corresponding weight percentages of the substances in the D phase in the whole are as follows: 0.2-0.4% of bisabolol;

the rest is added to 100 percent by deionized water in the B phase.

Further measures taken are: the corresponding weight percentages of the palm olein in the phase A based on the whole are as follows; the phase B also comprises soybean isoflavone.

Further measures taken are: the palm oil alcohol in the phase A accounts for 0.2 to 2.0 percent of the whole by weight; the soybean isoflavone in the phase B accounts for 0.1-0.5% of the total weight.

Further measures taken are: the phase D also comprises menthol and essence.

Further measures taken are: the menthol in the phase D accounts for 0.1 to 0.3 percent of the whole weight, and the essence accounts for 0.1 to 0.3 percent of the whole weight.

Further measures taken are: the mass ratio of the calcium hydroxide to the calcium thioglycolate is 1: (3-5).

A method for preparing a depilatory formulation comprising the steps of:

(1) cleaning and disinfecting production equipment and production tools, putting the substances with the corresponding weight percentage of the phase A into an oil phase pot, slowly heating to 80-85 ℃, and preserving heat for later use after the substances are completely dissolved;

(2) putting the substances with the corresponding weight percentage of the phase B into a water phase pot, heating to 80-85 ℃, and preserving heat for later use after the substances are completely dissolved;

(3) pumping most of the phase B for later use in the step (2) into an emulsifying pot, pumping the phase A for later use in the step (1) into the emulsifying pot, mixing and stirring, pumping the rest phase B into the emulsifying pot, emulsifying, keeping the temperature of the emulsifying pot at 80-85 ℃, vacuumizing, homogenizing, stirring, keeping the temperature, and cooling with cooling water;

(4) when the mixture emulsified in the step (3) is cooled to 65 ℃, adding substances with the corresponding weight percentage of the phase C into an emulsifying pot, uniformly stirring, vacuumizing, homogenizing, and cooling with cooling water;

(5) and (4) when the temperature of the mixture emulsified in the step (4) is reduced to 42 ℃, adding the substance with the corresponding weight percentage of the phase D into an emulsifying pot, stirring until the paste is fine and uniform, reducing the temperature to 38 ℃, inspecting, discharging, aging and standing, filling and warehousing to obtain a finished product.

Further measures taken are: the heat preservation time in the step (1) is 10 minutes; the heat preservation time in the step (2) is 20 minutes; the stirring and heat preservation time in the step (3) is 10 minutes; the time for vacuumizing and homogenizing in the step (3) is 5 minutes; the time for vacuumizing and homogenizing in the step (4) is 10 minutes.

Calcium thioglycolate is used as a depilatory ingredient, has relatively low irritation and limited addition amount, and is required to be not more than 5%, so that the depilatory effect achieved by calcium thioglycolate in the existing depilatory preparation is relatively general. The ratio of the calcium thioglycollate and the calcium hydroxide is optimized, stimulation is further reduced, the hair removal effect is improved, myristic acid is added, permeation is promoted through the myristic acid, calcium thioglycollate regulated by the calcium hydroxide penetrates into hair follicles, the roots of the hairs are softened through interaction of the calcium thioglycollate, the calcium hydroxide and the myristic acid, the hairs are easily removed together with the hairs after being softened, the hairs are not left, the hair removal effect is easy and thorough, the preparation method suitable for the substance is combined, the simplicity and effectiveness are achieved, the component stimulation is reduced, the mutual coordination effect is promoted, and the characteristics of mild overall effect and no stimulation are achieved.

The pine needle extract has good antioxidant and anti-aging effects, but in the depilatory preparation, through long-term intensive research of the invention, the pine needle extract also has good effects of shrinking pores, eliminating redness and swelling and resisting allergy in the depilatory cream; especially, the combination of the skin care product and hydroxyethyl cellulose, allantoin, olive (OLEAEUROPAEA) fruit oil, tocopherol acetate and the like are coordinated with each other, so that the excellent effects of conditioning the skin, shrinking pores, diminishing inflammation, sterilizing, resisting oxidation and firming the skin are achieved; the soybean isoflavone is combined with the pine needle extract, so that the effects of regulating skin hair follicles and shrinking pores can be achieved, the hair growth can be remarkably inhibited, the situation that the hair grows too fast after depilation is avoided, the depilation maintaining time is longer, the newly grown hair is fewer and fewer, the depilation is easier, and the soybean isoflavone and the pine needle extract lack one of the effects and the effects are far different.

The palm oil alcohol is added, belongs to higher fatty alcohol, is mild and safe, can be safely used by pregnant women, and has good effects of nourishing, lubricating and cleaning skin. The palm oil alcohol and the myristic acid are added to cooperate with each other, the hair follicle deep part is deepened to clean, moisten and condition the skin, the unhaired skin is smoother and moistened, the bisabolol and the menthol relieve the skin, the glycerin, the butanediol, the squalane and the like nourish and moisten the skin, the moisture content of the skin is improved, the elasticity is increased, the stability of overall collocation and effect exertion is improved, the affinity to the skin is improved, the overall skin is milder and more skin-friendly, and the effect is remarkable.

Through the technical scheme, compared with the prior art, the invention has the following beneficial effects:

1. the depilatory preparation can stretch into hair follicles to soften the roots of the hairs, enables the hair heads to be easily removed together with the hairs after being softened, achieves an easy and thorough depilatory effect, is mild in effect and free of irritation, and also has excellent effects of conditioning skin, shrinking pores, diminishing inflammation, sterilizing and remarkably inhibiting hair growth, avoids the situation that the hairs after depilation grow too fast, enables the depilation maintaining time to be longer, enables the newly grown hairs to be fewer and fewer, and enables the hairs to be more easily taken off.

2. The preparation method of the depilatory preparation is simple and effective, reduces component irritation, promotes the exertion of the mutual coordination effect, achieves mild and non-irritating overall effect, and ensures that the depilatory effect of the prepared depilatory preparation is more obvious.

Detailed Description

In order to clearly understand the technical solutions adopted by the present invention, the following description is made on the preferred embodiments of the present invention, and it should be understood that the embodiments described herein are only used for illustrating and explaining the present invention, and are not used to limit the present invention.

An epilatory formulation comprising phases a, B, C and D, examples 1-5 and comparative examples 1-4 comprising specific materials and the corresponding weight percentages as shown in table 1 below, with the balance being made up to 100% by deionized water in phase B.

Table 1: materials and proportions included in examples 1-5 and comparative examples 1-4

The above examples 1 to 5, and comparative examples 1 to 4 were each prepared by the following preparation method comprising the steps of:

(1) cleaning and disinfecting production equipment and production tools, putting the substances with the corresponding weight percentage of the phase A into an oil phase pot, slowly heating to 80-85 ℃, and preserving heat for 10 minutes for later use after the substances are completely dissolved;

(2) putting the substances with the corresponding weight percentage of the phase B into a water phase pot, heating to 80-85 ℃, and preserving the heat for 20 minutes for later use after the substances are completely dissolved;

(3) pumping most of the phase B for later use in the step (2) into an emulsifying pot, pumping the phase A for later use in the step (1) into the emulsifying pot, mixing and stirring, pumping the rest phase B into the emulsifying pot, emulsifying, keeping the temperature of the emulsifying pot at 80-85 ℃, vacuumizing, homogenizing for 5 minutes, stirring, keeping the temperature for 10 minutes, and then cooling by boiling cooling water;

(4) when the mixture emulsified in the step (3) is cooled to 65 ℃, adding substances with the corresponding weight percentage of the phase C into an emulsifying pot, uniformly stirring, vacuumizing, homogenizing for 10 minutes, and cooling with cooling water;

Wherein, the heat preservation time length and the vacuum homogenizing time length are controlled differently in each step. Through precise and accurate control of the heat preservation time length and the reaction time in different steps, the components in the depilatory preparation in the embodiment are fully reacted without mutual influence on the efficacy; and the homogenization step and the strict control of time ensure the uniformity and the stability of the whole mixing, and achieve the effects of improving the mutual synergistic action among all the substances, improving the whole stability and reducing the stimulation.

The depilatory cream preparation obtained by the invention can be prepared into depilatory cream or depilatory cream by adjusting according to the needs so as to meet more consumer demands.

The products obtained in the embodiments 1 to 5 were tested according to QB/T5108-2017 depilatory cream (milk), and the test results are as follows:

1. appearance: white cream/cream, fine, uniform and consistent cream

2. Odor: has no pungent odor and fragrance (flower fragrance), and meets the specified odor type.

pH (25 ℃ C.): the index range is 9.5-12.7, and the actual measurement is 10.2

4. Thioglycolic acid (mass fraction): the index range is less than or equal to 5 percent, and the actual measurement is 2.0 to 4.0 percent

5. And (3) investigating heat resistance stability: keeping the temperature at (40 +/-1) ℃ for 24 hours, and recovering the room temperature without oil-water separation or layering phenomenon, wherein the heat-resistant stability is qualified.

6. And (3) cold resistance stability investigation: keeping the temperature at (-8 +/-2) ℃ for 24 hours, and recovering the room temperature without layering or oil leakage, and the cold resistance and the stability are qualified.

7. The sanitation index is as follows: meets the regulation of' technical and safety standards for cosmetics

Second, skin irritation test

The rabbit eye conjunctival sac belongs to a sensitive part and is easy to be stimulated, 25 adult and healthy rabbits with the body weight of 1.5-2.0kg are selected in the test and randomly divided into 5 groups, and each group comprises 5 rabbits. The rabbit eye irritation test was carried out on 5 groups of rabbits corresponding to the products obtained in examples 1 to 5, respectively. The test method comprises the following steps: dripping the product of the corresponding group into the eye conjunctival sac of the rabbit of the corresponding group, passively closing the eyes for 1 minute, recording the change conditions of the eyes in the period of 12 hours, one day, two days, three days to seven days after the medicine is applied to the tested rabbit, and summarizing the results.

The experimental results are as follows: the eyes of the tested rabbits have no hyperemia on cornea, conjunctiva and iris of the eyes of each group of rabbits in 12 hours, one day, two days, three days to seven days after the administration, and have no abnormal conditions such as edema, turbidity, secretion and the like, and normal activity diet. It is shown that the products of examples 1-5 are non-irritating to the eyes of rabbits, and the depilatory cream formulation of this example is mild and non-irritating, and can be applied to sensitive skin.

A conventional depilatory cream was purchased on the market as a product of control 1, and the following comparative test was conducted with the products of this example and comparative example.

Third, depilatory effect and feeling of use test

In the same area, 100 volunteers aged 18 to 45 were recruited and randomly divided into 10 groups of 10 persons, and the 10 volunteers were tried for depilation on hand, foot and underarm using the products of examples 1 to 5, comparative examples 1 to 4 and the product of control group 1, respectively, and then the depilation condition and skin feeling of the depilation site were recorded and the feedback condition was collected for summary, and the results are shown in the following tables 2 and 3.

Table 2: comparative test results for depilation

As is apparent from Table 2 above, compared with the control group 1 using the conventional depilatory cream available in the market, the products of examples 1 to 5 of the present invention had excellent depilatory effect, and the depilation was cleaner and more complete and had no remaining of hairs. Further, the depilatory effect of comparative example 1 was far inferior to that of example 3, and thus, it was found that myristic acid has an important effect of improving the depilatory effect, and that only when calcium thioglycolate, calcium hydroxide and myristic acid act in concert with each other, the excellent depilatory effect as a whole could be achieved. The embodiment 3 is the best embodiment of the invention, has excellent depilatory effect, is mild and non-irritant, and can moisten and nourish the skin.

Table 3: comparative test results on feeling of depilation

As is apparent from Table 3 above, compared with the control group 1 in which conventional depilatory cream on the market is used for depilation, depilation using the products of examples 1 to 5 of the present invention has excellent effects of moisturizing and smoothing the skin, and is not comfortable and uncomfortable to use. However, the ratio of calcium thioglycolate to calcium hydroxide in comparative example 1 was adjusted, resulting in a slightly dry and rough feel for depilation using the product of comparative example 1, and a user experience far less comfortable than that of comparative example 3. Therefore, the ratio of calcium thioglycolate to calcium hydroxide needs to be strictly controlled, and a slight difference can cause a large difference in the result, so that the ratio of calcium thioglycolate to calcium hydroxide plays an important role in the effect, and the ratio is the optimal ratio range obtained by intensive research and numerous experiments of the inventor, and needs to be strictly controlled in the implementation process. Among them, example 3 is the most preferable example in this experiment.

Fourth, comparative test of depilation and suppression effects

55 mice of the same batch weighing between 35-50g were selected and randomly divided into 11 groups of 5 mice each.

Among them, the first 10 groups of mice were subjected to the hair growth inhibitory effect test corresponding to the products obtained in examples 1 to 5 and comparative examples 1 to 4, respectively, and the product of the commercially available control group 1. The test method comprises the following steps: uniformly coating 3g of depilatory cream products of corresponding groups on the same parts of the backs of all groups of test mice for depilatory treatment, wherein the depilatory area is 3cm x 3cm, observing the growth condition of hairs in the next 7 days, recording the time of the earliest growing of the hairs and calculating the average value in the groups, and also calculating the density degree of the newly growing hairs on the 7 th day (the evaluation degree is divided into very dense, thicker, sparser, very sparse and unobvious); uniformly coating 3g of depilatory cream products of corresponding groups on the original depilatory treated part on the 8 th day for the second depilatory treatment, observing the growth condition of the hair in the next 7 days after the second depilatory treatment, recording the time of the hair growing earliest from the second depilatory treatment, and calculating the average value in the group, and also recording the density of the newly growing hair on the 7 th day after the second depilatory treatment (the evaluation of the density is divided into very dense, sparse, very sparse and unobvious); the summary is shown in table 4 below.

Randomly selecting 1 group of experimental mice as a blank control group to carry out blank control test, wherein the test method comprises the following steps: uniformly coating 3g of deionized water on the same part of the back of a test mouse, then carrying out unhairing treatment by using a shaver, wherein the unhairing area is 3cm x 3cm, observing the growth condition of hairs in the next 7 days, recording the time of the earliest growing hairs and calculating the average value in a group, and further, the new growing hair density degree on the 7 th day; uniformly coating 3g of deionized water on the original unhairing part on the 8 th day, then carrying out secondary unhairing treatment by using a shaver, observing the growth condition of the hair in the next 7 days after the secondary unhairing, recording the time of the earliest hair growth from the secondary unhairing, calculating an average value in a group, and obtaining the new hair growth density degree on the 7 th day after the secondary unhairing; the results are summarized in Table 4 below.

Table 4: inhibition comparative test results

As is apparent from table 4 above, compared with the control group 1 that depilates with the conventional depilatory cream available in the market, depilatory with the products of examples 1 to 4 of the present invention has a significant effect of inhibiting hair growth, so that the depilatory effect lasts longer, and newly growing hair becomes more and more sparse, and depilatory with the products of examples 1 to 4 for a long time, subsequently growing new hair becomes more and more sparse, so that depilatory becomes easier. It is apparent from example 4, comparative example 2 and comparative example 4 that soybean isoflavone and pine needle extract have important effects on hair growth inhibition, and the hair growth inhibition effects are far from each other in the absence of either one of them, and the combination of both exerts a significant hair growth inhibition effect. Among them, example 3 is the most preferable example in this experiment.

The depilatory preparation has excellent depilatory effect, can inhibit the growth of depilated hair, is non-irritant, mild and skin-friendly, meets the detection standard, and is suitable for popularization and application.

The above description is only for the purpose of illustrating the embodiments of the present invention and not for the purpose of limiting the same, and equivalent modifications and variations of the embodiments of the present invention will be apparent to those skilled in the art without departing from the overall spirit of the invention.

Claims

1. A depilatory formulation, characterized by: comprises a phase A, a phase B, a phase C and a phase D;

phase D comprises the following substances: bisabolol.

2. A depilatory formulation according to claim 1, characterised in that: the substances in the phase A account for the following corresponding weight percentages of the whole: 1.0 to 5.0 percent of squalane, 1.0 to 5.0 percent of polydimethylsiloxane, 21.0 to 5.0 percent of ceteareth-21, 5 to 3.0 percent of ceteareth-210, 5 to 3.0 percent of olive (OLEA EUROPAEA) fruit oil, 0.1 to 0.8 percent of tocopherol acetate, 0.5 to 3.0 percent of cetearyl alcohol and 0.5 to 1.0 percent of myristic acid;

the rest is added to 100 percent by deionized water in the B phase.

3. A depilatory formulation according to claim 2, characterised in that: the substances in the phase A account for the following corresponding weight percentages of the whole: squalane 2.0-4.0%, polydimethylsiloxane 2.0-4.0%, ceteareth-22.0-4.0%, ceteareth-211.0-2.5%, olive (OLEA EUROPAEA) fruit oil 0.5-3.0%, tocopherol acetate 0.1-0.8%, cetearyl alcohol 1.0-2.5%, myristic acid 0.3-0.6%;

the rest is added to 100 percent by deionized water in the B phase.

4. A depilatory formulation according to claim 1, characterised in that: the phase a also includes palm olein; the phase B also comprises soybean isoflavone.

5. A depilatory formulation according to claim 4, characterised in that: the palm oil alcohol in the phase A accounts for 0.2 to 2.0 percent of the whole by weight; the soybean isoflavone in the phase B accounts for 0.1-0.5% of the total weight.

6. A depilatory formulation according to claim 1, characterised in that: the phase D also comprises menthol and essence.

7. A depilatory formulation according to claim 6, characterised in that: the menthol in the phase D accounts for 0.1 to 0.3 percent of the whole weight, and the essence accounts for 0.1 to 0.3 percent of the whole weight.

8. A depilatory formulation according to claim 2, characterised in that: the mass ratio of the calcium hydroxide to the calcium thioglycolate is 1: (3-5).

9. A process for the preparation of a depilatory formulation as claimed in any one of claims 1 to 8, wherein: the method comprises the following steps:

(2) putting the substances in the phase B in a corresponding weight percentage into a water phase pot, heating to 80-85 ℃, and preserving heat for later use after the substances are completely dissolved;

10. A process for the preparation of a depilatory formulation as claimed in claim 9, wherein: the heat preservation time in the step (1) is 10 minutes; the heat preservation time in the step (2) is 20 minutes; the stirring and heat preservation time in the step (3) is 10 minutes; the time for vacuumizing and homogenizing in the step (3) is 5 minutes; the time for vacuumizing and homogenizing in the step (4) is 10 minutes.