CN112154165A - 用于增白牙齿的新型聚合物、组合物、方法及套件 - Google Patents
用于增白牙齿的新型聚合物、组合物、方法及套件 Download PDFInfo
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- CN112154165A CN112154165A CN201980033937.XA CN201980033937A CN112154165A CN 112154165 A CN112154165 A CN 112154165A CN 201980033937 A CN201980033937 A CN 201980033937A CN 112154165 A CN112154165 A CN 112154165A
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- WUKWITHWXAAZEY-UHFFFAOYSA-L calcium difluoride Chemical compound [F-].[F-].[Ca+2] WUKWITHWXAAZEY-UHFFFAOYSA-L 0.000 description 1
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- 239000007791 liquid phase Substances 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
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- 230000002165 photosensitisation Effects 0.000 description 1
- 208000017983 photosensitivity disease Diseases 0.000 description 1
- 231100000434 photosensitization Toxicity 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- WYOHGPUPVHHUGO-UHFFFAOYSA-K potassium;oxygen(2-);titanium(4+);phosphate Chemical compound [O-2].[K+].[Ti+4].[O-]P([O-])([O-])=O WYOHGPUPVHHUGO-UHFFFAOYSA-K 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 239000003642 reactive oxygen metabolite Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 235000019192 riboflavin Nutrition 0.000 description 1
- 239000002151 riboflavin Substances 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 150000003287 riboflavins Chemical class 0.000 description 1
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- 230000035945 sensitivity Effects 0.000 description 1
- 238000010898 silica gel chromatography Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011775 sodium fluoride Substances 0.000 description 1
- 235000013024 sodium fluoride Nutrition 0.000 description 1
- 229960000414 sodium fluoride Drugs 0.000 description 1
- 229940079862 sodium lauryl sarcosinate Drugs 0.000 description 1
- 229940075560 sodium lauryl sulfoacetate Drugs 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 1
- ADWNFGORSPBALY-UHFFFAOYSA-M sodium;2-[dodecyl(methyl)amino]acetate Chemical compound [Na+].CCCCCCCCCCCCN(C)CC([O-])=O ADWNFGORSPBALY-UHFFFAOYSA-M 0.000 description 1
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 description 1
- JNYAEWCLZODPBN-CTQIIAAMSA-N sorbitan Polymers OCC(O)C1OCC(O)[C@@H]1O JNYAEWCLZODPBN-CTQIIAAMSA-N 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 229960002799 stannous fluoride Drugs 0.000 description 1
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000000979 synthetic dye Substances 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
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- 229920001864 tannin Polymers 0.000 description 1
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- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 235000019149 tocopherols Nutrition 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
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Abstract
本发明涉及一种新型聚合物,用于口腔护理组合物中以增白牙齿。本发明还涉及一种制备该聚合物的方法和一种套件,该套件含有所述组合物与光源。该聚合物的特征在于包括附接于其中的呫吨染料部分。
Description
技术领域
本发明涉及一种新型聚合物,其用于口腔护理组合物中以增白牙齿。更具体地,本发明涉及这种组合物和含有所述组合物与光源的套件。
背景技术
我们牙齿的颜色受到其固有颜色和其上可能形成的任何外在污渍的存在的组合影响。着色与物质被吸附到牙釉质表面上的表膜中有关。影响外在污渍形成的因素包括刷牙方法不当、吸烟、饮食中摄入带有颜色的食物(例如红葡萄酒)、年龄以及使用某些阳离子试剂如氯己定或锡和铁的金属盐。消费者们强烈希望牙齿能够变得更白,一些个体对他们牙齿的内在颜色或对污渍是不满意的。对更洁白牙齿的这种需求导致从牙膏到漱口水和口香糖的增白产品的增长趋势。
意图用于增白的牙膏依靠研磨剂和化学组分的优化以去除污渍。在刷牙过程中,这些研磨剂颗粒通过暂时截留在牙刷和(牙齿的)受污表面之间以磨去污渍。通常,还可以与研磨剂颗粒结合使用化学组分,这些化学组分包括钙螯合剂、聚合物、表面活性剂、酶和氧化剂。
一种较为普遍的方法涉及使用含有像过氧化氢这样的漂白剂与一种或多种其他漂白剂的洁齿剂,如US2002122776A和WO0018366 A1中所公开的(皆属于Unilever)。
EP1935395A1(Unilever)描述了一种新型的牙齿增白的光学方法,其中牙膏含有能沉积于牙齿表面上的蓝色颜料(特别是Blue Covarine)。这能够改变表面的光学效果,导致感觉牙齿更白。类型的聚合物能帮助沉积。
US2009238778AA(McNeil-PPC)公开了能够通过光能活化的牙齿增白组合物。该组合物含有核黄素或核黄素衍生物、漂白剂和水溶性液体相。
本发明涉及一种新型聚合物,用于包括在口腔护理组合物中,使得在不依赖于漂白剂的情况下,该组合物提供的牙齿增白作用强于迄今为止公开的那些组合物所提供的牙齿增白作用。发明人试图通过在聚合物上附加(tagging)光敏染料,然后通过光照射在涂有所述聚合物的牙齿上来活化所述染料,从而实现上述目的。他们发现,相比于已知的组合物,某些呫吨类染料在结合至特定类聚合物时,能够在有光射入到涂有所述聚合物的牙齿上时更好地增白牙齿。
WO2010149534公开了一种口腔护理组合物,其包括用于改进牙齿颜色的染料聚合物,其主要包括蒽醌部分。它们通过牙齿上的染料的直接作用而起效,但是在光照射在其上面时不提供提升的白度。
因此,本发明的目的是提供一种能够掺入口腔护理组合物中以提供增加的牙齿增白的新型聚合染料。
本发明的另一目的是提供一种包括该新型聚合染料的口腔护理组合物,在有光照射在涂有所述组合物的牙齿上时,该口腔护理组合物展示出强化的牙齿增白。
发明内容
本发明的第一方面涉及一种聚合物,其具有以下结构:
其中,
R1为CnH2n+1;
R2为二杂官能团;
n的数值为1-10;
x的数值为1-10,000;
y的数值为1-10,000;
P为聚醚链;以及
D为选自以下至少一种的呫吨染料:
酸性红52、酸性红289、茜素紫,溴代邻苯三酚红、2′,7′-二氯荧光素钠盐、9-(4′-二甲基氨基苯基)-2,6,7-三羟基荧光酮硫酸盐水合物、二溴荧光素、荧光素二钾(UranineK)、荧光素、荧光素钠(Uranine)、邻苯三酚红、磺酰荧光素(Sulfonfluorescein)、四溴荧光素钾盐、酸性红91(曙红B(Eosin Bluish))、酸性红94(玫瑰红)、酸性红87(曙红)、酸性红92(荧光桃红B)、3,4,5,6-四氯荧光素、四碘荧光素(藻红B或赤藓红B)和苯基荧光酮。
特别优选地,呫吨染料为玫瑰红、曙红、荧光桃红B、荧光素或赤藓红中的一种。
本发明的第二方面涉及一种口腔护理组合物,其包括第一方面的聚合物和化妆品上可接受的载体。
根据本发明的第三方面,提供一种制备本发明的第一方面的聚合物的方法,其包括以下步骤:
首先合成染料单体,然后合成染料聚合物。概括化的方法包括以下步骤:
(a)通过如下过程合成染料单体:使染料、氯甲基苯乙烯、碳酸钾和二甲基甲酰胺的混合物回流6-10小时;用盐溶液洗涤、干燥、过滤及浓缩,从而制得染料单体;和
(b)通过如下过程合成染料聚合物:在20-70℃的温度范围内,使低聚(乙二醇)甲基醚丙烯酸酯OEGMA、染料单体、偶氮二异丁腈AIBN和二噁烷在惰性气氛中反应1-10小时,然后在过量***中将其沉淀,重复循环;随后在20-40℃范围内的低温下在真空下将其干燥。
本发明的另一方面涉及一种部件套件(kit-of-parts),其包括:
(i)第二方面的口腔护理组合物;
(ii)光化性光/可见光/LED光的源;
(iii)任选存在的用于将所述组合物涂覆至牙齿的施涂器;和,
(iv)进一步任选存在的一套部件套件的使用说明书。
本发明的又另一方面涉及一种用于增白牙齿的器件,其包括用于将第二方面的组合物涂覆至牙齿的施涂器;和与所述器件集成的光化性光/可见光/LED光的源。
本发明的又另一方面涉及一种增白牙齿的方法,其包括将第二方面的口腔护理组合物涂覆到牙齿表面上,然后使所述经涂覆的组合物暴露至光化性光/可见光/LED光的源。
本发明的又另一方面涉及第二方面的口腔护理组合物用于增白牙齿的用途。
本发明的又另一方面涉及一种包装产品,其包括本发明的第二方面的口腔护理组合物。
发明详述
本发明的一个方面的任何特征都可以用于本发明的任何其他方面。“包括”一词用于表示“包括…在内”,但并不一定是“由…组成”或“由…构成”。换言之,所列出的步骤或选项不必是穷尽性的。除非在操作实例和对比实例中或另有明确表示,本说明书中表示材料的量或反应条件、材料的物理性质和/或用量的所有数值都应理解为由“约”一词修饰。以“x-y”格式表示的数值范围应理解为包括x和y。在针对某特定特征以“x-y”格式描述多个优选范围时,应理解为组合不同端点的所有范围也考虑在内。
凡涉及术语“重量%”或“以重量计%”都应解读为指所涉及的成分按组合物重量计的%,除非有相反的表示。
术语“光化性光”意在表示特定光源(例如,可见光、紫外光、灯具、LED或激光)发出的、能够被物质(例如下文定义的发色团或光活化剂)吸收的光能。优选地,光化性光是可见光。
术语“光敏剂”指任何能够吸收光化性光的试剂。光敏剂经过光激发,然后传递其能量。其可以是发射光(例如,荧光)的形式和/或向分子传递能量。该能量可以引发化学反应。光敏剂可以强化或加速光能分散,或以其他方式强化和/或激活氧化剂的分解。
当提及水基凝胶组合物的pH值时,所述pH值在以1重量份的组合物均匀分散和/或溶解于20重量份纯水的情况下在25℃下测量。具体地,可以通过如下方式测量pH值:通过将1g组合物与20ml水手动混合30秒,随后立即用试纸或pH计测试pH值。
组合物粘度为用布氏粘度计4号转轴以5rpm的速度在室温(25℃)下观测并记录的值。粘度数值以厘泊(cP=mPa.s)为单位记录,除非另有说明。
着色的牙齿可能变得麻烦,无论其原因是固有的还是外在的因素或试剂,如某些饮料和氯己定。对于一些个体,污渍在牙齿上的积聚造成美学问题。污渍通常在本质上是外在的,一般表示表膜和/或斑块的变色。有关污渍形成的确切机制还没有完全了解。有人提出由产色细菌产生的颜料、来自表膜组分的化学转化和饮食成分的吸附/保留的着色产物促进外在污渍。似乎在很大程度上引致着色的饮食因素包括咖啡、茶和红酒以及吸烟。除了氯己定之外,其他阳离子抗微生物剂例如海克替啶或季铵化合物也会促进沾染。
这种组合物和套件的功效可以通过称为白度观察指数(WIO)的术语来测量和评价。Luo等人提出的指数(即WIO)与前述白度指数中的一些具有相同的功能形式,但是参数不同,并且其特别地优化用于牙齿白度的评价。其被认为最适合于评价牙齿白度的变化。
Luo等人提出了改良版的CIE白度指数(Garcia JA,Rubino M,Romero J,Hita E.的Measuring The Whiteness Of Human Teeth.Color Research and Application 1993;18:349–52)。其直接基于3D比色板的观察者评分,并定义为:
WIO=Y+1075.012(xp–x)+145.516(yp–y)
发明的聚合染料
本发明的聚合染料具有以下的一般性结构:
其中,
R1为CnH2n+1;
R2为二杂官能团;
n的数值为1-10;
x的数值为1-10,000;
y的数值为1-10,000;
P为聚醚链;以及
D为选自如下至少一种的呫吨染料:酸性红52、酸性红289、茜素紫、溴代邻苯三酚红、2′,7′-二氯荧光素钠盐、9-(4′-二甲基氨基苯基)-2,6,7-三羟基荧光酮硫酸盐水合物、二溴荧光素、荧光素二钾、荧光素、荧光素钠、邻苯三酚红、磺酰荧光素、四溴荧光素钾盐、酸性红91(曙红B)、酸性红94(玫瑰红)、酸性红87(曙红)、酸性红92(荧光桃红B)、3,4,5,6-四氯荧光素、四碘荧光素(藻红B或赤藓红B)和苯基荧光酮。
在上述结构中,n优选具有数值1-5。最优选地n的数值为1。在此情况下,R1最优选CH3。R2为选自O-或COO-的二杂官能团,更优选为-O-。
虽然聚合物链可以很长,x的数值为1-10,000,且y的数值为1-10,000,x优选的数值为1-500,更优选为5-100。同样,y优选的数值为1-500,更优选为5-100。
上述一般性结构中的P基团优选为具有如下结构的聚乙二醇链:
P=聚乙二醇链
R3=H或磷酸根或-CnH2n+1
在上述聚乙二醇基团中,优选n的数值为1-10。在上述聚乙二醇基团中,优选z的数值为1-10。
在本发明的第一方面的染料聚合物中,染料基团D为包括呫吨基团的基团。
呫吨类染料的一般性结构中的一种如下:
其中,R1、R2、R3、R4、R5和R6为官能团,例如–OH、H、Br、I、Cl、胺、酮、O-M+(其中M为金属离子),R7为有机部分/衍生物,例如取代的芳族基团或苯并呋喃。
依据本发明的优选方面,光敏剂选自呫吨类染料,呫吨类染料选自以下中的一种:酸性红52、酸性红289、茜素紫、溴代邻苯三酚红、2′,7′-二氯荧光素钠盐、9-(4′-二甲基氨基苯基)-2,6,7-三羟基荧光酮硫酸盐水合物、二溴荧光素、荧光素二钾、荧光素、荧光素钠、邻苯三酚红、磺酰荧光素、四溴荧光素钾盐、酸性红91(曙红B)、酸性红94(玫瑰红)、酸性红87(曙红)、酸性红92(荧光桃红B)、3,4,5,6-四氯荧光素、四碘荧光素(藻红B或赤藓红B)和苯基荧光酮。
然而,特别优选光敏剂为玫瑰红、曙红、荧光桃红B、荧光素或赤藓红中的至少一种。
优选形式的呫吨染料的一般性结构如下:
参见以上示出的化学结构,在荧光素中,X=H,Y=H;在曙红中,X=Br,Y=H;在赤藓红中,X=I,Y=H,以及在玫瑰红中,X=I,Y=Cl。
本发明的特别优选方面涉及第一方面的聚合物,其中D为具有以下化学结构的曙红基团:
采用曙红为染料时,单体与曙红的COOH基团反应并结合。
本发明的组合物旨在增白牙齿,这意味着其可用于保持牙齿的白度。或者,本发明的组合物可用于至少部分地去除或淡化一些常见污渍,例如茶渍或咖啡渍。
根据本发明的第二方面,提供了一种口腔护理组合物,其包括第一方面的聚合物和化妆品上可接受的载体。
所述口腔护理组合物优选包括以组合物的重量计0.1-10重量%,更优选0.1-5重量%的聚合物。
本发明的水基凝胶组合物的pH值优选为3-11,更优选为6-8。
根据本发明的组合物可以任选包括其他成分,以提升性能和/或消费者接受度,这将在下面简单讨论。
合适的表面活性剂包括阴离子表面活性剂,例如以下的钠盐、镁盐、铵盐或乙醇胺盐:C8-C18烷基硫酸盐(例如月桂基硫酸钠)、C8-C18烷基磺基琥珀酸盐(例如二辛基磺基琥珀酸钠)、C8-C18烷基磺基乙酸盐(例如月桂基磺基乙酸钠)、C8-C18烷基肌氨酸盐(例如月桂基肌氨酸钠)、C8-C18烷基磷酸盐(其可以任选包含高达10个的氧化乙烯和/或氧化丙烯单元)以及硫酸盐化的单甘油酯。其他合适的表面活性剂包括非离子表面活性剂,例如任选存在的聚乙氧基化的脂肪酸脱水山梨糖醇酯、乙氧基化的脂肪酸、聚乙二醇的酯、脂肪酸甘油单酯和甘油二酯的乙氧基化物,以及氧化乙烯/氧化丙烯嵌段聚合物。其他合适的表面活性剂包括两性离子表面活性剂,例如甜菜碱或磺基甜菜碱。也可以使用任何上述材料的混合物。
基于组合物的总重量,按表面活性剂总重量计,表面活性剂的含量范围通常可以为0.2-15%。
优选地包括胶凝剂,以与聚合物一起获得需要的粘度。优选的胶凝剂为胶凝剂为丙烯酰基二甲基牛磺酸铵与乙烯基吡硌烷酮的共聚物、改性明胶或聚乙烯醇或其组合。以组合物的重量计,可以包括0.1-10%、更优选0.1-2%的胶凝剂。
同样适用的有氟化物源,例如氟化钠、氟化亚锡、单氟磷酸钠、氟化锌铵、氟化锡铵、氟化钙、氟化钴铵及其混合物;植物衍生的抗氧化剂如黄酮类、儿茶素、多酚和单宁化合物及其混合物;抗氧化剂维生素,如生育酚类和/或其衍生物、抗坏血酸和/或其衍生物及其混合物。还可以包括本领域常用的其它的任选的成分,例如缓冲剂、增香剂、甜味剂、着色剂、遮光剂和防腐剂。
根据本发明的第三方面,提供了一种制备本发明的第一方面的聚合物的方法,其包括以下步骤:首先合成染料单体,然后合成聚合物。一般化性的方法包括以下步骤:
(a)通过如下过程合成染料单体:使染料、氯甲基苯乙烯、碳酸钾和二甲基甲酰胺的混合物回流6-10小时;然后用盐溶液洗涤、干燥、过滤及浓缩,从而制得染料单体;以及
(b)通过如下过程合成染料聚合物:使低聚(乙二醇)甲基醚丙烯酸酯OEGMA、染料单体、偶氮二异丁腈(AIBN)和二噁烷在惰性气氛中在20-70℃范围的温度下反应1-10小时,然后在过量***中将其沉淀,重复循环;随后在20-40℃范围内的低温下在真空下干燥。
一般性方法的更多细节包括以下两个部分:(i)合成染料单体,和(ii)合成聚合物。
染料单体的合成
将染料、氯甲基苯乙烯、碳酸钾和二甲基甲酰胺装入反应烧瓶中,使该混合物回流6-10小时。在将所有溶剂都蒸发掉后,将残余物溶解在二氯甲烷(CH2Cl2)中,依次用饱和氯化钠水溶液和水洗涤,用无水硫酸镁干燥,过滤,然后在旋转蒸发器上浓缩。
染料聚合物的合成
将低聚(乙二醇)甲基醚丙烯酸酯(OEGMA)、染料单体、偶氮二异丁腈AIBN和二噁烷装入反应烧瓶中。通过三次冷冻-泵吸-融化循环对混合物脱气,然后再回充氮气。在70℃下搅拌5-10小时后,将反应管骤冷至液氮中,打开并暴露于空气,并沉淀至过量***中。重复上述溶解-沉淀循环三次。将最终产物在真空烘箱中于室温下干燥过夜,得到红色固体。
本发明组合物优选为凝胶。优选地,凝胶的粘度为200-100,000cp,更优选为2000-50,000cp。
发明的部件套件
根据本发明的另一方面,本发明涉及一种部件套件,其包括:
(i)第二方面的口腔护理组合物;
(ii)光化性光/可见光/LED光的源;
(iii)任选存在的用于将所述组合物涂覆至牙齿的施涂器;以及
(iv)进一步任选存在的所述部件套件的一套使用说明书。
根据本发明的组合物需要与合适的光化性光源结合使用。
任何合适的光化性光的源都可以使用,只要其能够活化属于呫吨基团的光敏剂即可。合适的光化性光的源的主要特点可以是其发出一个波长(或多个波长)适于组合物中存在的光敏剂的光敏作用的光。
优选地,光化性光的源为卤素灯、LED或等离子弧光灯,或激光器如氩激光器、磷酸钛氧钾(KTP)激光器、LED光固化器件。虽然辐照优选可见光范围的,但其可以是紫外光(UV)或红外光(IR)。优选地,光化性光的波长范围为约400nm至约700nm。在另一实施方案中,光化性光的波长范围为约420nm至约560nm,更优选为435nm至约550nm。
施涂器优选US20030194383A(Unilever)中公开的施涂器。该施涂器或托盘包括可固定在人牙齿上的U形牙托盘,其允许本发明的组合物与包围牙齿的所有可能表面接触。或者,施涂器为本领域已知的任何其他合适的施涂器。
该套说明书优选地为含有关于内容物和使用本发明组合物的逐步说明的有用信息的小册子形式。
不希望受理论的限制,发明人相信,通过具有与聚合物结合的光敏剂的本发明的第一方面的聚合物,可以更好地将所述聚合物沉积在牙齿上,从而光敏剂部分也能更好沉积;其使得当暴露至优选白色可见光时,光敏剂会产生活性氧物质,后者进而与牙齿上存在的牙渍发色团相互作用,将其分解为能被洗掉的较小无色分子,从而去除/淡化牙渍。结果是牙齿更白。
发明的器件
根据另一方面,公开一种用于增白牙齿的器件,其包括:
(i)用于将第二方面的组合物涂覆至牙齿的施涂器;和
(ii)与所述器件集成的光化性光的源。
作为例子,考虑到发出可见光,可以参见之前所公开的可安装的托盘,在此情形下,优选地所述器件包括开启或关闭光源的开关或按钮。该器件优选地还包括为光源提供能量的电池。在此情形下,优选的是该器件易于使用。
发明的包装产品
根据另一方面,公开一种包装产品,其包括本发明的口腔护理组合物。该组合物优选包装于可折叠管中,使得无需过多技巧便可容易地少量分配。或者,该组合物包装于另一类型的容器如瓶子或罐子中,优选带有合适的分配确定量组合物的装置。该包装体可以进一步包装于合适的二次包装像纸箱或盒子中,优选带有关于内容物和使用说明书的有用信息。
发明的方法
根据另一方面,公开了一种增白牙齿的方法,其包括:
(i)将第二方面的口腔护理组合物涂覆到牙齿表面上;和
(ii)使所述经涂覆的组合物暴露至光化性光/可见光/LED光的源。
优选地,使用之前所公开的施涂器来涂覆组合物。涂覆后,使牙齿暴露至可见光优选5-45分钟,更优选不超过10分钟。或者,暴露持续少于5分钟,例如4分钟、3分钟、2分钟或1分钟。涂覆可以每当需要就重复,例如每日2-3次,两星期3-4天。优选地,该方法导致比色卡上至少一个单位的色差(shade difference),优选至少2个单位,更优选至少3-5个单位的色调差。所述方法相对地摆脱了后处理敏感症。在一些其他情况下,存在最小或可接受水平的后处理敏感症。在处理后,增白效果可随时间减弱。在那种情况下,建议进行重复处理。
所述用于增白牙齿的方法可以在牙科医生的办公室或在常规或监督条件下的诊所进行。或者更优选地,所述方法由了解情况的使用者在家进行,或者换言之,当所述方法是非治疗性时,可以在没有任何医学监督下进行。
本发明的组合物和方法可用于增白牙齿。这意味着该组合物可用于保持牙齿的白色外观或定期修复外观。或者,所述组合物和方法可用于亮化由于外来或固有污渍(例如,烟草、咖啡、茶叶和/或食物或葡萄酒污渍)、氟中毒、发育障碍、细菌、遗传、四环素抗生素、创伤、血液分解、牙齿发育期间存在的色素所引起变色的牙齿。
在一个方面,所述方法是非治疗性的。优选地,这样的方法是美容方法。治疗性处理是从病理状态开始的,而非治疗性处理则是从正常健康的状态开始。向人施用这样的方法可以改善他的身体外观(美容处理)。
在另一个方面,所述方法本质上是治疗性的。通过疗法进行的治疗定义为目的是治愈、减缓、除去或减轻人体(在该情况下,其为牙齿)的任何紊乱或机能障碍的症状、或预防或减少罹患任何紊乱或机能障碍的可能性的任何治疗。
根据本发明的用途
根据本发明的又另一方面,公开了第二方面的口腔护理组合物用于增白牙齿的用途。
在一方面,所述用途是用于非治疗目的的。或者,所述用途是用于治疗目的的。涉及本发明方法的说明书的部分加以必要的修改后也适用于本发明的这一方面。
下列实施例将更充分地说明本发明的实施方式。除非另外说明,否则在本文和在随附权利要求书中提及的全部份数、百分数和比例都以重量计。
具体实施方式
实施例
曙红基可聚合染料EoS的合成
将曙红Y(647mg,1mmol)、氯甲基苯乙烯(152mg,1mmol)、碳酸钾(275mg,2mmol)和二甲基甲酰胺(DMF)(5ml)装入反应烧瓶中,将混合物回流6小时。在蒸发掉所有溶剂后,将残余物溶解在二氯甲烷(CH2Cl2)中,并依次用饱和氯化钠水溶液和水洗涤,用无水硫酸镁干燥,过滤,然后在旋转蒸发器上浓缩。使粗产物通过硅胶柱色谱法进行进一步的纯化,使用CH2Cl2/甲醇(98/2v/v)作为洗脱剂,得到残留固体的4-乙烯基苄基2-(2,4,5,7-四溴-6-羟基-3-氧代-3H-呫吨-9-基)苯甲酸盐(EoS)(540mg,67%产率)。1H NMR(DMSO-d6,δ,ppm,TMS):8.22(d,1H,芳族质子)、7.92(m,2H,芳族质子)、7.42(d,1H,芳族质子)、7.25(d,2H,芳族质子)、6.95(s,2H,芳族质子)、6.82(d,2H,芳族质子)、6.62(q,1H,-CH=CH2)、5.76(d,1H,-CH=CHH)、5.28(d,1H,-CH=CHH)、4.96(s,2H,COO-CH2-)。
实施例1:聚(OEGMA-共-EoS)的合成OEGMA-低聚(乙二醇)甲基醚丙烯酸酯
将OEGMA(9.5g,20mmol)、EoS(0.015g,0.2mmol)、AIBN偶氮二异丁腈(0.008g,0.05mmol)和二噁烷(19mL)装入反应烧瓶中。通过三次冷冻-泵吸-融化循环对混合物脱气,然后再回充氮气。在70℃下搅拌5小时后,将反应管骤冷至液氮中,打开并暴露于空气,并沉淀至过量***中。重复上述溶解-沉淀循环三次。最终产物在真空烘箱中于室温下干燥过夜,得到红色固体(6.6g,产率:69%)。聚(OEGMA-共-EoS)的分子量和分子量分布在使用DMF作为洗脱剂通过GPC测定,结果显示Mn为22,300,Mw/Mn为1.84。
光漂白方案:
所有凝胶样品均在软化水中制备。
量=每个HAP圆片70-80mg凝胶
光源=光谱LED灯14B 22
板与灯之间的距离=1.5cm
曝光时间=30分钟
循环次数=4次
每次循环后均用常规牙膏刷牙,以去除多余的凝胶。
拍摄照片以确定样品的视觉影响,并在4次循环后测量L*、a*和b*。
视觉数据
在用实施例1-3的样品处理之后,观察染色(stained)的HAP圆片的视觉图像,随后进行曝光。
循环次数=4
包含曙红聚合物(实施例1)和游离曙红(实施例2)的凝胶组合物表现出光漂白功效。与实施例2相比,实施例1的凝胶样品显示出优异的光漂白。
L、a、b数据
用上述凝胶处理后,测量染色的HAP圆片的ΔL值,并将数据汇总在下表中:
实施例 | 样品 | ΔL |
1 | 0.5%的聚合物有效浓度,曙红0.02% | 40 |
2 | 0.02%的曙红在凝胶中 | 34 |
3 | 对照 | -10 |
上表中的数据表明,与将所述染料简单地配制在凝胶中的组合物相比,具有本发明的组合物(实施例1)的HAP圆片具有优异的光漂白性能。
观察到的增白指数(WIO)数据
测量相同样品的WIO值,并将数据汇总在下表中:
实施例 | 样品 | WIO |
1 | 0.5%的聚合物有效浓度,曙红0.02% | 78 |
2 | 0.02%的曙红在凝胶中 | 65 |
3 | 对照 | -20 |
WIO测度证实了与ΔL测量以及视觉观察所获得的趋势相似的趋势,其中发现聚合物染料优于其他样品。
Claims (14)
1.一种聚合物,其具有如下结构:
其中,
R1为CnH2n+1;
R2为二杂官能团;
n的数值为1-10;
x的数值为1-10,000;
y的数值为1-10,000;
P为聚醚链;以及
D为选自如下的至少一种的呫吨染料:酸性红52、酸性红289、茜素紫、溴代邻苯三酚红、2′,7′-二氯荧光素钠盐、9-(4′-二甲基氨基苯基)-2,6,7-三羟基荧光酮硫酸盐水合物、二溴荧光素、荧光素二钾、荧光素、荧光素钠、邻苯三酚红、磺酰荧光素、四溴荧光素钾盐、酸性红91(曙红B)、酸性红94(玫瑰红)、酸性红87(曙红)、酸性红92(荧光桃红B)、3,4,5,6-四氯荧光素、四碘荧光素(藻红B或赤藓红B)和苯基荧光酮。
2.根据权利要求1中所述的聚合物,其中所述R1为CH3。
3.根据权利要求1或2中所述的聚合物,其中所述R2为-O-基团。
4.根据前述权利要求中任一项所述的聚合物,其中x的数值为5-100。
5.根据前述权利要求中任一项所述的聚合物,其中y的数值为5-100。
7.根据前述权利要求中任一项所述的聚合物,其中D为玫瑰红、曙红、荧光桃红B、荧光素或赤藓红中的至少一种。
9.一种口腔护理组合物,其包括:
(i)根据前述权利要求中任一项所述的聚合物;和
(ii)化妆品上可接受的载体。
10.一种制备如权利要求1所述的聚合物的方法,其包括以下步骤:
(a)通过如下过程合成染料单体:使染料、氯甲基苯乙烯、碳酸钾和二甲基甲酰胺的混合物回流6-10小时;用盐溶液洗涤、干燥、过滤及浓缩,以制备所述染料单体;以及
(b)通过如下过程合成染料聚合物:使OEGMA(低聚(乙二醇)甲基醚丙烯酸酯)、染料单体、AIBN(偶氮二异丁腈)和二噁烷在20-70℃的温度范围内在惰性气氛中反应1-10小时,使其在过量***中沉淀,重复循环;随后在20-40℃范围内的低温下在真空下干燥。
11.一种部件套件,其包括:
(i)根据权利要求9所述的组合物;
(ii)光化性光/可见光/LED光的源;
(iii)任选存在的用于将所述组合物涂覆至牙齿的施涂器;和
(iv)进一步任选存在的一套所述部件套件的使用说明书。
12.一种用于增白牙齿的器件,其包括:
(i)用于将权利要求11所述的组合物涂覆至牙齿的施涂器;和
(ii)和与所述器件集成的光化性光/可见光/LED光的源。
13.一种增白牙齿的方法,其包括:
(i)将根据权利要求9所述的组合物涂覆到牙齿表面上;以及
(ii)使所述经涂覆的组合物暴露至光化性光/可见光/LED光的源。
14.根据权利要求9所述的组合物用于增白牙齿的用途。
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