CN112121077A - Traditional Chinese medicine lotion for treating hemorrhoids - Google Patents

Traditional Chinese medicine lotion for treating hemorrhoids Download PDF

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CN112121077A
CN112121077A CN202011168757.3A CN202011168757A CN112121077A CN 112121077 A CN112121077 A CN 112121077A CN 202011168757 A CN202011168757 A CN 202011168757A CN 112121077 A CN112121077 A CN 112121077A
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chinese medicine
traditional chinese
treating hemorrhoids
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唐昆尧
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Chongqing Peidu Pharmaceutical Co ltd
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Chongqing Peidu Pharmaceutical Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/536—Prunella or Brunella (selfheal)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288—Taraxacum (dandelion)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
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  • Veterinary Medicine (AREA)
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  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
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  • Heart & Thoracic Surgery (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
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  • Medicines Containing Plant Substances (AREA)
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Abstract

The invention discloses a traditional Chinese medicine lotion for treating hemorrhoids, which is characterized by being prepared from the following raw materials in parts by weight: 400 portions of selfheal 200-. The Chinese medicinal composition is prepared by extracting the Chinese medicinal raw materials consisting of the formula to prepare a medicinal active substance, and then preparing the medicinal active substance serving as the raw material according to the conventional technology of pharmaceutics. The functional indications are as follows: the Chinese medicinal lotion has the advantages of clearing away heat and toxic materials, promoting blood circulation, removing blood stasis, relieving swelling and pain, and treating hemorrhoids, and has the advantages of economy, short treatment period, quick response, and no toxic or side effect.

Description

Traditional Chinese medicine lotion for treating hemorrhoids
Technical Field
The invention relates to a traditional Chinese medicine lotion for treating hemorrhoids, and belongs to the technical field of traditional Chinese medicines.
Background
Hemorrhoids are common and frequently encountered clinical diseases of anorectal department. Hemorrhoids are divided into 3 types of internal hemorrhoids, external hemorrhoids and mixed hemorrhoids, and clinically, local inflammation, swelling and pain, hematochezia and prolapse are the main symptoms. The surgical excision method has long treatment course and great pain, is not easy to be accepted by patients, and has more formulations of the medicaments for treating the hemorrhoids, the oral medicaments comprise tablets, pills, capsules or granules, the external medicaments comprise suppositories, salves and powder, and the local injections are mainly divided into two types of necrosis agents and hardening agents. The main pharmacodynamics of the oral medicine and the external medicine are inflammation diminishing, bleeding stopping, pain relieving, astringing, corrosion resisting and the like. The traditional Chinese medicine fumigation and washing becomes the main means of treatment with good curative effect and simple and convenient use method.
Disclosure of Invention
Aiming at the technical problems, the invention aims to provide the traditional Chinese medicine lotion for treating the hemorrhoids, which has good curative effect and no toxic or side effect.
In order to achieve the aim, the invention provides a traditional Chinese medicine lotion for treating hemorrhoids, which is characterized by being prepared from the following raw materials in parts by weight: 400 portions of selfheal 200-.
Preferably: the composite material is prepared from the following raw materials in parts by weight: 300 parts of selfheal, 300 parts of dandelion, 250 parts of barberry root and 300 parts of sophora flower bud.
In the scheme, the method comprises the following steps: decocting Spica Prunellae, herba Taraxaci, radix Berberidis and flos Sophorae Immaturus coarse powder in water, filtering, concentrating the decoction, adding sodium benzoate, press filtering, adding distilled water, mixing, and packaging to obtain the final product.
In the scheme, the method comprises the following steps: decocting twice, wherein the water adding amount of each decoction is 10-11 times of the total weight of the dry medicines, and the decocting time is 1-1.5 h.
In the scheme, the method comprises the following steps: the filtrate was concentrated to 1-1.5g crude drug per ml water.
In the scheme, the method comprises the following steps: the addition amount of the sodium benzoate is 0.4-0.6% of the weight of the concentrated solution.
In the scheme, the method comprises the following steps: the distilled water is added according to the weight of the concentrated solution and the equal proportion.
The traditional Chinese medicine lotion belongs to solution type lotion, and has original medicine smell and no mildew, peculiar smell, color change, turbidity and precipitate. The invention is prepared by extracting the traditional Chinese medicine raw materials consisting of the formula to prepare the active pharmaceutical substance, and then taking the active pharmaceutical substance as the raw material according to the conventional technology of pharmaceutics. The functional indications are as follows: the traditional Chinese medicine lotion has the advantages of clearing away heat and toxic materials, promoting blood circulation to remove blood stasis, and relieving swelling and pain, is mainly used for treating hemorrhoids, is economical, short in treatment period, easy to accept by patients, quick in effect, and free of toxic and side effects.
Detailed Description
The invention is further illustrated by the following examples:
example 1
A traditional Chinese medicine for treating hemorrhoids is prepared from 200g of selfheal, 200g of dandelion, 150g of barberry root and 200g of sophora flower bud.
Decocting Spica Prunellae, herba Taraxaci, radix Berberidis and flos Sophorae Immaturus coarse powder with water twice, wherein the amount of water added for each decoction is 10 times of the total weight of the dry medicinal materials, and the decocting time is 1 h. Decocting, filtering, mixing filtrates, concentrating to 750mL, adding 0.4% sodium benzoate, press filtering, adding 750mL distilled water, mixing, subpackaging into 100 mL/bottle, and labeling. When in use, a bottle of the product is taken, diluted to 1500ml by hot water, smoked for 3-5 minutes, and then subjected to hip bath for 30 minutes for 2 times a day. 5-7 days is 1 course of treatment, and 2-3 courses of treatment are generally good.
Example 2
A traditional Chinese medicine for treating hemorrhoids is prepared from 400g of selfheal, 400g of dandelion, 350g of barberry root and 400g of sophora flower bud.
Decocting Spica Prunellae, herba Taraxaci, radix Berberidis and flos Sophorae Immaturus coarse powder with water twice, wherein the amount of water added for each decoction is 11 times of the total weight of the dry medicinal materials, and the decocting time is 1.5 h. Decocting, filtering, mixing filtrates, concentrating to 1000mL, adding 0.6% sodium benzoate, press filtering, adding 1000mL distilled water, mixing, subpackaging into 100 mL/bottle, and labeling. When in use, a bottle of the product is taken, diluted to 1500ml by hot water, smoked for 3-5 minutes, and then subjected to hip bath for 30 minutes for 2 times a day. 5-7 days is 1 course of treatment, and 2-3 courses of treatment are generally good.
Example 3
A Chinese medicinal composition for treating hemorrhoid is prepared from Prunellae Spica 300g, herba Taraxaci 300g, radix Berberidis 250g, and flos Sophorae Immaturus 300 g.
Decocting Spica Prunellae, herba Taraxaci, radix Berberidis and flos Sophorae Immaturus coarse powder with water twice, wherein the amount of water added for each decoction is 11 times of the total weight of the dry medicinal materials, and the decocting time is 1.5 h. Decocting, filtering, mixing filtrates, concentrating to 1000mL, adding 0.5% sodium benzoate, press filtering, adding 1000mL distilled water, mixing, subpackaging into 100 mL/bottle, and labeling. When in use, a bottle of the product is taken, diluted to 1500ml by hot water, smoked for 3-5 minutes, and then subjected to hip bath for 30 minutes for 2 times a day. 5-7 days is 1 course of treatment, and 2-3 courses of treatment are generally good.
Pharmacology and toxicology
1. Study of pharmacodynamics
The invention takes sophora flower bud as a main drug and is combined with berberis poiretii schneid, dandelion and prunella vulgaris. Simple formula, low cost and good curative effect.
The flos Sophorae Immaturus contains rutin (Rut) and quercetin (Que) as effective components, wherein the rutin has pharmacological activities of reducing capillary permeability, resisting inflammation and allergy, and the rutin injected into abdominal cavity of rat has obvious inhibition effect on inflammation process of implanted wool ball; quercetin has dose-dependent anti-hemorrhage and analgesic effects, and rutin also has analgesic effect.
Root of Chinese barberry, name of Chinese medicine. Is root bark or stem bark of Berberis vulgaris L.var.prunifolia (berberis thunb.) kurz, Berberis pruinosa L.var.prunifolia (berberis thunb.) kurz, Callicarpa kurossi et al, belonging to berberidaceae. Root bark can be harvested all year round. Harvesting stems and branches in spring and autumn, scraping the outer skins of the stems and branches, peeling the dark yellow inner skins, and drying in the sun. Bitter taste and cold nature. Has effects of clearing heat, promoting diuresis, and removing blood stasis. Can be used for treating dysentery with bloody stool, jaundice, pharyngalgia, conjunctival congestion, and traumatic injury.
Dandelion has the effects of clearing away heat and toxic materials, inducing diuresis and resolving masses. It can be used for treating acute mastitis, lymphadenitis, lymphoid tuberculosis, furunculosis, acute conjunctivitis, common cold with fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, and urinary tract infection.
Spica Prunellae, clears heat and purges fire, improves eyesight, and eliminates stagnation and subsides swelling.
The invention is combined in whole formula and is used for treating hemorrhoids.
1.1 inhibitory Effect of the extract of the present invention on ear swelling of mice caused by xylene
The male Kunming mice 90 were randomly divided into 9 groups of 10 mice each. Examples 1 and 3 two test samples were set to be 0.15g/kg in the low dose group and 0.30g/kg in the high dose group, respectively, and 7 experimental groups of normal saline, tween-80-normal saline, and aspirin. Each group was administered by gavage for 3 days continuously, and after 2h of the last administration (1 h of aspirin administration), 0.05mL of xylene was applied to both the front and back sides of the right ear of the mouse, the cervical vertebra was dislocated and sacrificed after 15min, a punch with a diameter of 9mm was used to punch and sample the same portions of the left and right auricles, weighing was performed in time, the inhibition rate and the swelling degree were calculated, statistical treatment was performed by t-test, and compared with the control group.
The water extract of the invention with the dosage of 0.30g/kg has obvious inhibition effect on mouse ear swelling caused by dimethylbenzene, the inhibition rates are respectively 35.18 percent and 42.14 percent, the ratio of the water extract to negative control group 2 and group 1 is obviously different (P is less than 0.05), and the results are shown in table 1.
Table 1 anti-inflammatory effect of the extract of the invention on swelling of mouse ears by xylene (n-10,
Figure BDA0002746635500000041
)
Figure BDA0002746635500000042
Figure BDA0002746635500000051
p <0.05 compared to tween-80-saline group; p <0.05 compared to saline group
1.2 the extract of the present invention has a significant inhibitory effect on capillary permeability, as shown in Table 2.
Table 2 effect of the extracts of the invention on the permeability of the capillaries in the abdominal cavity of mice (n-10,
Figure BDA0002746635500000052
)
Figure BDA0002746635500000053
p <0.05 compared with Tween-80-normal saline
From the above table, it can be seen that the traditional Chinese medicine composition has a significant inhibiting effect on chemical red swelling of the auricularia porch and increased capillary permeability of mice, and can obviously relieve red, swollen and hot symptoms of acute inflammatory reaction.
1.3 analgesic Effect test
The grouping and results are shown in Table 1, the invention (50 or 100 mg. kg)-1Ip) can significantly improve the mouse whizzing stimulus threshold, 100 mg/kg-1The peak effect of the medicine of the invention is 4 mg-kg of Mor (buprenorphine)-1The equivalent, i.e. the potency of the invention (example 3) is about 1/25 for Mor (buprenorphine).
Table 3 increasing effect of Rut on mouse electrical hissing threshold (n 10,
Figure BDA0002746635500000054
)
Figure BDA0002746635500000061
p <0.05, P <0.01t test compared to pre-dose
2. Toxicology studies
Acute toxicity and long-term toxicity test: rat abdominal cavity injection acute LD50245mg/kg and a gavage of 328 mg/kg. For dogs injected with 40 mg/kg or 50mg/kg for 24 days, no bone marrow suppression is seen, and after the injection is administered with 60mg/kg for 24 days, cold tremor, contracture and no local irritation can be seen. The lotion has no adverse reaction when being used, which indicates that the lotion is safe and reliable.
Clinical research application:
clinical data: 432 hemorrhoid patients, internal hemorrhoid, external hemorrhoid, and mixed hemorrhoid were randomly divided into 218 treatment groups and 214 control groups; 230 male and 202 female.
The treatment method comprises taking a bottle of the product, diluting with hot water to 1500ml, fumigating for 3-5 min, and hip-bathing for 30 min 2 times a day. 5-7 days is 1 course of treatment, and 2-3 courses of treatment are common; taking a potassium permanganate solution with the ratio of 1: 500 in the control group, and carrying out hip bath for 1-2 times/d after defecation until the control group is healed.
The curative effect standard is that the wound has no pain, no blood and exudate, and the wound surface is healed to be obvious; the pain of the wound is relieved, the wound has little effusion and no blood seepage, and the wound surface is effectively healed; the pain of the wound is not improved, the phenomena of exudate and blood are generated on the part, and the wound surface is not healed.
The treatment results comprise that 218 patients in the treatment group have obvious effect of 96 patients and 122 patients have effect, and the total effective rate is 100 percent; 214 cases of the control group, 6 cases of significant effect, 110 cases of effect and 98 cases of no effect, and the total effective rate is 54 percent.
The present invention is not limited to the above-described embodiments, and those skilled in the art will understand that: various changes, modifications, substitutions and alterations can be made to the embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the claims and their equivalents.

Claims (7)

1. The traditional Chinese medicine lotion for treating hemorrhoids is characterized by being prepared from the following raw materials in parts by weight: 400 portions of selfheal 200-.
2. The traditional Chinese medicine for treating hemorrhoids as claimed in claim 1, is characterized by being prepared from the following raw materials in parts by weight: 300 parts of selfheal, 300 parts of dandelion, 250 parts of barberry root and 300 parts of sophora flower bud.
3. The traditional Chinese medicine for treating hemorrhoids according to claims 1-2, wherein: decocting Spica Prunellae, herba Taraxaci, radix Berberidis and flos Sophorae Immaturus coarse powder in water, filtering, concentrating the decoction, adding sodium benzoate, press filtering, adding distilled water, mixing, and packaging to obtain the final product.
4. The traditional Chinese medicine for treating hemorrhoids as claimed in claim 3, wherein: decocting twice, wherein the water adding amount of each decoction is 10-11 times of the total weight of the dry medicines, and the decocting time is 1-1.5 h.
5. The traditional Chinese medicine for treating hemorrhoids as claimed in claim 4, wherein: the filtrate was concentrated to 1-1.5g per ml.
6. The traditional Chinese medicine for treating hemorrhoids as claimed in claim 5, wherein: the addition amount of the sodium benzoate is 0.4-0.6% of the weight of the concentrated solution.
7. The traditional Chinese medicine for treating hemorrhoids as claimed in claim 6, wherein: the distilled water is added according to the weight of the concentrated solution and the equal proportion.
CN202011168757.3A 2020-10-28 2020-10-28 Traditional Chinese medicine lotion for treating hemorrhoids Pending CN112121077A (en)

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Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
（清）江进纂辑；邱玏校注: "《集古良方》", 30 June 2012, 中医古籍出版社 *
刘孟宇等主编: "《常用中药的拓展应用》", 31 August 2010, 人民军医出版社 *
吴德峰主编: "《实用中草药》", 31 October 2017, 上海科学技术出版社 *

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Application publication date: 20201225