CN112118848A - 产后产妇营养的健康补充物 - Google Patents
产后产妇营养的健康补充物 Download PDFInfo
- Publication number
- CN112118848A CN112118848A CN201980031177.9A CN201980031177A CN112118848A CN 112118848 A CN112118848 A CN 112118848A CN 201980031177 A CN201980031177 A CN 201980031177A CN 112118848 A CN112118848 A CN 112118848A
- Authority
- CN
- China
- Prior art keywords
- nutritional composition
- per serving
- sialyllactose
- amount
- postpartum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 235000016709 nutrition Nutrition 0.000 title claims abstract description 131
- 230000035764 nutrition Effects 0.000 title description 8
- 235000015872 dietary supplement Nutrition 0.000 title description 5
- 239000000203 mixture Substances 0.000 claims abstract description 147
- OIZGSVFYNBZVIK-FHHHURIISA-N 3'-sialyllactose Chemical compound O1[C@@H]([C@H](O)[C@H](O)CO)[C@H](NC(=O)C)[C@@H](O)C[C@@]1(C(O)=O)O[C@@H]1[C@@H](O)[C@H](O[C@H]([C@H](O)CO)[C@H](O)[C@@H](O)C=O)O[C@H](CO)[C@@H]1O OIZGSVFYNBZVIK-FHHHURIISA-N 0.000 claims abstract description 32
- 239000006041 probiotic Substances 0.000 claims abstract description 32
- 235000018291 probiotics Nutrition 0.000 claims abstract description 32
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims abstract description 30
- 238000000034 method Methods 0.000 claims abstract description 27
- 239000000284 extract Substances 0.000 claims abstract description 26
- 229930003316 Vitamin D Natural products 0.000 claims abstract description 25
- 235000019166 vitamin D Nutrition 0.000 claims abstract description 25
- 239000011710 vitamin D Substances 0.000 claims abstract description 25
- 150000003710 vitamin D derivatives Chemical class 0.000 claims abstract description 25
- 229940046008 vitamin d Drugs 0.000 claims abstract description 25
- 235000003392 Curcuma domestica Nutrition 0.000 claims abstract description 23
- 235000003373 curcuma longa Nutrition 0.000 claims abstract description 23
- 230000000529 probiotic effect Effects 0.000 claims abstract description 23
- 235000013976 turmeric Nutrition 0.000 claims abstract description 23
- 244000008991 Curcuma longa Species 0.000 claims abstract description 21
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 19
- 239000011575 calcium Substances 0.000 claims abstract description 19
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 19
- 235000001484 Trigonella foenum graecum Nutrition 0.000 claims abstract description 15
- 244000250129 Trigonella foenum graecum Species 0.000 claims abstract description 15
- 235000001019 trigonella foenum-graecum Nutrition 0.000 claims abstract description 15
- 230000036541 health Effects 0.000 claims abstract description 12
- 235000020978 long-chain polyunsaturated fatty acids Nutrition 0.000 claims abstract description 12
- 201000009916 Postpartum depression Diseases 0.000 claims abstract description 11
- 239000004615 ingredient Substances 0.000 claims abstract description 11
- 208000019901 Anxiety disease Diseases 0.000 claims abstract description 10
- 230000036506 anxiety Effects 0.000 claims abstract description 10
- 241000218588 Lactobacillus rhamnosus Species 0.000 claims abstract description 6
- 235000014571 nuts Nutrition 0.000 claims description 34
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 claims description 27
- 235000020669 docosahexaenoic acid Nutrition 0.000 claims description 22
- 239000000843 powder Substances 0.000 claims description 19
- 235000012754 curcumin Nutrition 0.000 claims description 13
- 239000004148 curcumin Substances 0.000 claims description 13
- 229940109262 curcumin Drugs 0.000 claims description 13
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 claims description 13
- 239000007788 liquid Substances 0.000 claims description 11
- 235000020124 milk-based beverage Nutrition 0.000 claims description 7
- TYALNJQZQRNQNQ-UHFFFAOYSA-N #alpha;2,6-sialyllactose Natural products O1C(C(O)C(O)CO)C(NC(=O)C)C(O)CC1(C(O)=O)OCC1C(O)C(O)C(O)C(OC2C(C(O)C(O)OC2CO)O)O1 TYALNJQZQRNQNQ-UHFFFAOYSA-N 0.000 claims description 6
- CILYIEBUXJIHCO-UHFFFAOYSA-N 102778-91-6 Natural products O1C(C(O)C(O)CO)C(NC(=O)C)C(O)CC1(C(O)=O)OC1C(O)C(OC2C(C(O)C(O)OC2CO)O)OC(CO)C1O CILYIEBUXJIHCO-UHFFFAOYSA-N 0.000 claims description 6
- DVGKRPYUFRZAQW-UHFFFAOYSA-N 3 prime Natural products CC(=O)NC1OC(CC(O)C1C(O)C(O)CO)(OC2C(O)C(CO)OC(OC3C(O)C(O)C(O)OC3CO)C2O)C(=O)O DVGKRPYUFRZAQW-UHFFFAOYSA-N 0.000 claims description 6
- CILYIEBUXJIHCO-UITFWXMXSA-N N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucose Chemical compound O1[C@@H]([C@H](O)[C@H](O)CO)[C@H](NC(=O)C)[C@@H](O)C[C@@]1(C(O)=O)O[C@@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)O[C@@H]2CO)O)O[C@H](CO)[C@@H]1O CILYIEBUXJIHCO-UITFWXMXSA-N 0.000 claims description 6
- OIZGSVFYNBZVIK-UHFFFAOYSA-N N-acetylneuraminosyl-D-lactose Natural products O1C(C(O)C(O)CO)C(NC(=O)C)C(O)CC1(C(O)=O)OC1C(O)C(OC(C(O)CO)C(O)C(O)C=O)OC(CO)C1O OIZGSVFYNBZVIK-UHFFFAOYSA-N 0.000 claims description 6
- TYALNJQZQRNQNQ-JLYOMPFMSA-N alpha-Neup5Ac-(2->6)-beta-D-Galp-(1->4)-beta-D-Glcp Chemical compound O1[C@@H]([C@H](O)[C@H](O)CO)[C@H](NC(=O)C)[C@@H](O)C[C@@]1(C(O)=O)OC[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)O[C@@H]2CO)O)O1 TYALNJQZQRNQNQ-JLYOMPFMSA-N 0.000 claims description 6
- 235000020257 nut milk Nutrition 0.000 claims description 5
- DVSZKTAMJJTWFG-SKCDLICFSA-N (2e,4e,6e,8e,10e,12e)-docosa-2,4,6,8,10,12-hexaenoic acid Chemical compound CCCCCCCCC\C=C\C=C\C=C\C=C\C=C\C=C\C(O)=O DVSZKTAMJJTWFG-SKCDLICFSA-N 0.000 claims description 3
- GZJLLYHBALOKEX-UHFFFAOYSA-N 6-Ketone, O18-Me-Ussuriedine Natural products CC=CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O GZJLLYHBALOKEX-UHFFFAOYSA-N 0.000 claims description 3
- KAUVQQXNCKESLC-UHFFFAOYSA-N docosahexaenoic acid (DHA) Natural products COC(=O)C(C)NOCC1=CC=CC=C1 KAUVQQXNCKESLC-UHFFFAOYSA-N 0.000 claims description 3
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 3
- 235000008924 yoghurt drink Nutrition 0.000 claims description 3
- 229930153442 Curcuminoid Natural products 0.000 claims 1
- 230000009286 beneficial effect Effects 0.000 abstract description 4
- 239000000654 additive Substances 0.000 abstract description 3
- 230000000996 additive effect Effects 0.000 abstract description 3
- 230000008821 health effect Effects 0.000 abstract description 3
- 230000008774 maternal effect Effects 0.000 abstract description 3
- 230000001737 promoting effect Effects 0.000 abstract description 3
- 230000002195 synergetic effect Effects 0.000 abstract description 3
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 description 39
- 230000015556 catabolic process Effects 0.000 description 19
- 238000006731 degradation reaction Methods 0.000 description 19
- 229940090949 docosahexaenoic acid Drugs 0.000 description 19
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical group [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 16
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 description 16
- 235000001465 calcium Nutrition 0.000 description 16
- 229960005069 calcium Drugs 0.000 description 16
- 235000013336 milk Nutrition 0.000 description 15
- 239000008267 milk Substances 0.000 description 15
- 210000004080 milk Anatomy 0.000 description 15
- VWHGTYCRDRBSFI-ZETCQYMHSA-N Leu-Gly-Gly Chemical compound CC(C)C[C@H](N)C(=O)NCC(=O)NCC(O)=O VWHGTYCRDRBSFI-ZETCQYMHSA-N 0.000 description 13
- 239000003921 oil Substances 0.000 description 12
- 235000019198 oils Nutrition 0.000 description 12
- 229910052500 inorganic mineral Inorganic materials 0.000 description 11
- 235000010755 mineral Nutrition 0.000 description 11
- 239000011707 mineral Substances 0.000 description 11
- 239000000047 product Substances 0.000 description 9
- 235000021342 arachidonic acid Nutrition 0.000 description 8
- 229940114079 arachidonic acid Drugs 0.000 description 8
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 8
- 229910052742 iron Inorganic materials 0.000 description 8
- 229940088594 vitamin Drugs 0.000 description 8
- 229930003231 vitamin Natural products 0.000 description 8
- 235000013343 vitamin Nutrition 0.000 description 8
- 239000011782 vitamin Substances 0.000 description 8
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 7
- 235000008504 concentrate Nutrition 0.000 description 7
- 239000012141 concentrate Substances 0.000 description 7
- 239000008101 lactose Substances 0.000 description 7
- 241000894006 Bacteria Species 0.000 description 6
- 102000007544 Whey Proteins Human genes 0.000 description 6
- 108010046377 Whey Proteins Proteins 0.000 description 6
- 239000008122 artificial sweetener Substances 0.000 description 6
- 235000021311 artificial sweeteners Nutrition 0.000 description 6
- 230000001850 reproductive effect Effects 0.000 description 6
- 239000011647 vitamin D3 Substances 0.000 description 6
- 241000283690 Bos taurus Species 0.000 description 5
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 5
- 235000013361 beverage Nutrition 0.000 description 5
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 description 5
- 239000001354 calcium citrate Substances 0.000 description 5
- 229960004256 calcium citrate Drugs 0.000 description 5
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 5
- 235000013365 dairy product Nutrition 0.000 description 5
- 235000019152 folic acid Nutrition 0.000 description 5
- 239000011724 folic acid Substances 0.000 description 5
- 150000002632 lipids Chemical class 0.000 description 5
- 244000005700 microbiome Species 0.000 description 5
- 239000013589 supplement Substances 0.000 description 5
- 235000013337 tricalcium citrate Nutrition 0.000 description 5
- 235000005282 vitamin D3 Nutrition 0.000 description 5
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 5
- 229940021056 vitamin d3 Drugs 0.000 description 5
- 239000005773 FEN 560 (Fenugreek seed powder) Substances 0.000 description 4
- 241000917009 Lactobacillus rhamnosus GG Species 0.000 description 4
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 4
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 4
- 244000299461 Theobroma cacao Species 0.000 description 4
- 239000005862 Whey Substances 0.000 description 4
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 229910000365 copper sulfate Inorganic materials 0.000 description 4
- 235000013399 edible fruits Nutrition 0.000 description 4
- 239000003995 emulsifying agent Substances 0.000 description 4
- 239000000796 flavoring agent Substances 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 229940059406 lactobacillus rhamnosus gg Drugs 0.000 description 4
- 235000018102 proteins Nutrition 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 235000011962 puddings Nutrition 0.000 description 4
- 235000000346 sugar Nutrition 0.000 description 4
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 4
- 150000003722 vitamin derivatives Chemical class 0.000 description 4
- 235000013618 yogurt Nutrition 0.000 description 4
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 4
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 3
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 3
- 241001608472 Bifidobacterium longum Species 0.000 description 3
- 241000186015 Bifidobacterium longum subsp. infantis Species 0.000 description 3
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 3
- 235000009499 Vanilla fragrans Nutrition 0.000 description 3
- 244000263375 Vanilla tahitensis Species 0.000 description 3
- 235000012036 Vanilla tahitensis Nutrition 0.000 description 3
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 description 3
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 3
- 150000001720 carbohydrates Chemical class 0.000 description 3
- 235000014633 carbohydrates Nutrition 0.000 description 3
- 235000019219 chocolate Nutrition 0.000 description 3
- 235000013312 flour Nutrition 0.000 description 3
- 229960000304 folic acid Drugs 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 235000013355 food flavoring agent Nutrition 0.000 description 3
- 235000015097 nutrients Nutrition 0.000 description 3
- 235000006180 nutrition needs Nutrition 0.000 description 3
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 3
- 239000012465 retentate Substances 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- DNISEZBAYYIQFB-PHDIDXHHSA-N (2r,3r)-2,3-diacetyloxybutanedioic acid Chemical class CC(=O)O[C@@H](C(O)=O)[C@H](C(O)=O)OC(C)=O DNISEZBAYYIQFB-PHDIDXHHSA-N 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 241000186000 Bifidobacterium Species 0.000 description 2
- 241000186012 Bifidobacterium breve Species 0.000 description 2
- 241000167854 Bourreria succulenta Species 0.000 description 2
- 235000009025 Carya illinoensis Nutrition 0.000 description 2
- 244000068645 Carya illinoensis Species 0.000 description 2
- 244000163122 Curcuma domestica Species 0.000 description 2
- PMVSDNDAUGGCCE-TYYBGVCCSA-L Ferrous fumarate Chemical compound [Fe+2].[O-]C(=O)\C=C\C([O-])=O PMVSDNDAUGGCCE-TYYBGVCCSA-L 0.000 description 2
- 206010022998 Irritability Diseases 0.000 description 2
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 description 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- BAWFJGJZGIEFAR-NNYOXOHSSA-N NAD zwitterion Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-N 0.000 description 2
- 208000002366 Nut Hypersensitivity Diseases 0.000 description 2
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 2
- 241000018646 Pinus brutia Species 0.000 description 2
- 235000011613 Pinus brutia Nutrition 0.000 description 2
- RADKZDMFGJYCBB-UHFFFAOYSA-N Pyridoxal Chemical compound CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 2
- VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- 229940087168 alpha tocopherol Drugs 0.000 description 2
- 235000020661 alpha-linolenic acid Nutrition 0.000 description 2
- 229940004120 bifidobacterium infantis Drugs 0.000 description 2
- 229940009291 bifidobacterium longum Drugs 0.000 description 2
- 239000001506 calcium phosphate Substances 0.000 description 2
- 229910000389 calcium phosphate Inorganic materials 0.000 description 2
- 229960001714 calcium phosphate Drugs 0.000 description 2
- 235000011010 calcium phosphates Nutrition 0.000 description 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
- 235000010418 carrageenan Nutrition 0.000 description 2
- 239000000679 carrageenan Substances 0.000 description 2
- 229920001525 carrageenan Polymers 0.000 description 2
- 229940113118 carrageenan Drugs 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 235000019693 cherries Nutrition 0.000 description 2
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 description 2
- 235000014510 cooky Nutrition 0.000 description 2
- RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 235000020673 eicosapentaenoic acid Nutrition 0.000 description 2
- 229960005135 eicosapentaenoic acid Drugs 0.000 description 2
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 description 2
- 239000011773 ferrous fumarate Substances 0.000 description 2
- 235000002332 ferrous fumarate Nutrition 0.000 description 2
- 229960000225 ferrous fumarate Drugs 0.000 description 2
- 239000011790 ferrous sulphate Substances 0.000 description 2
- 235000003891 ferrous sulphate Nutrition 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 239000011714 flavin adenine dinucleotide Substances 0.000 description 2
- 235000019162 flavin adenine dinucleotide Nutrition 0.000 description 2
- 239000011768 flavin mononucleotide Substances 0.000 description 2
- FVTCRASFADXXNN-SCRDCRAPSA-N flavin mononucleotide Chemical compound OP(=O)(O)OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O FVTCRASFADXXNN-SCRDCRAPSA-N 0.000 description 2
- FVTCRASFADXXNN-UHFFFAOYSA-N flavin mononucleotide Natural products OP(=O)(O)OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O FVTCRASFADXXNN-UHFFFAOYSA-N 0.000 description 2
- 235000013572 fruit purees Nutrition 0.000 description 2
- VZCCETWTMQHEPK-UHFFFAOYSA-N gamma-Linolensaeure Natural products CCCCCC=CCC=CCC=CCCCCC(O)=O VZCCETWTMQHEPK-UHFFFAOYSA-N 0.000 description 2
- VZCCETWTMQHEPK-QNEBEIHSSA-N gamma-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCC(O)=O VZCCETWTMQHEPK-QNEBEIHSSA-N 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 230000007366 host health Effects 0.000 description 2
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 2
- WBJZTOZJJYAKHQ-UHFFFAOYSA-K iron(3+) phosphate Chemical compound [Fe+3].[O-]P([O-])([O-])=O WBJZTOZJJYAKHQ-UHFFFAOYSA-K 0.000 description 2
- 229910000359 iron(II) sulfate Inorganic materials 0.000 description 2
- 229910000399 iron(III) phosphate Inorganic materials 0.000 description 2
- 229960004232 linoleic acid Drugs 0.000 description 2
- 229960004488 linolenic acid Drugs 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 229950006238 nadide Drugs 0.000 description 2
- 201000010854 nut allergy Diseases 0.000 description 2
- 235000019161 pantothenic acid Nutrition 0.000 description 2
- 239000011713 pantothenic acid Substances 0.000 description 2
- 239000006072 paste Substances 0.000 description 2
- 235000021400 peanut butter Nutrition 0.000 description 2
- 239000012466 permeate Substances 0.000 description 2
- 239000011772 phylloquinone Substances 0.000 description 2
- SCVFZCLFOSHCOH-UHFFFAOYSA-M potassium acetate Chemical compound [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 description 2
- 239000001103 potassium chloride Substances 0.000 description 2
- 235000011164 potassium chloride Nutrition 0.000 description 2
- 229910000160 potassium phosphate Inorganic materials 0.000 description 2
- 235000011009 potassium phosphates Nutrition 0.000 description 2
- 239000002243 precursor Substances 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- NHZMQXZHNVQTQA-UHFFFAOYSA-N pyridoxamine Chemical compound CC1=NC=C(CO)C(CN)=C1O NHZMQXZHNVQTQA-UHFFFAOYSA-N 0.000 description 2
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 2
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 2
- 229960003471 retinol Drugs 0.000 description 2
- 235000020944 retinol Nutrition 0.000 description 2
- 239000011607 retinol Substances 0.000 description 2
- -1 retinol esters Chemical class 0.000 description 2
- QGNJRVVDBSJHIZ-QHLGVNSISA-N retinyl acetate Chemical compound CC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C QGNJRVVDBSJHIZ-QHLGVNSISA-N 0.000 description 2
- 229960002477 riboflavin Drugs 0.000 description 2
- 235000019231 riboflavin-5'-phosphate Nutrition 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- JZRWCGZRTZMZEH-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 2
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 2
- 239000011678 thiamine pyrophosphate Substances 0.000 description 2
- 235000008170 thiamine pyrophosphate Nutrition 0.000 description 2
- 229960000984 tocofersolan Drugs 0.000 description 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 2
- 239000011708 vitamin B3 Substances 0.000 description 2
- 239000000341 volatile oil Substances 0.000 description 2
- 235000021119 whey protein Nutrition 0.000 description 2
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 2
- 229960001763 zinc sulfate Drugs 0.000 description 2
- 229910000368 zinc sulfate Inorganic materials 0.000 description 2
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 2
- 239000002076 α-tocopherol Substances 0.000 description 2
- 235000004835 α-tocopherol Nutrition 0.000 description 2
- UEPVWRDHSPMIAZ-IZTHOABVSA-N (1e,4z,6e)-5-hydroxy-7-(4-hydroxy-3-methoxyphenyl)-1-(4-hydroxyphenyl)hepta-1,4,6-trien-3-one Chemical compound C1=C(O)C(OC)=CC(\C=C\C(\O)=C\C(=O)\C=C\C=2C=CC(O)=CC=2)=C1 UEPVWRDHSPMIAZ-IZTHOABVSA-N 0.000 description 1
- YUFFSWGQGVEMMI-JLNKQSITSA-N (7Z,10Z,13Z,16Z,19Z)-docosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCCCC(O)=O YUFFSWGQGVEMMI-JLNKQSITSA-N 0.000 description 1
- HOBAELRKJCKHQD-UHFFFAOYSA-N (8Z,11Z,14Z)-8,11,14-eicosatrienoic acid Natural products CCCCCC=CCC=CCC=CCCCCCCC(O)=O HOBAELRKJCKHQD-UHFFFAOYSA-N 0.000 description 1
- GMRQFYUYWCNGIN-ZVUFCXRFSA-N 1,25-dihydroxy vitamin D3 Chemical compound C1([C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=CC=C1C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-ZVUFCXRFSA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- PYMYPHUHKUWMLA-UHFFFAOYSA-N 2,3,4,5-tetrahydroxypentanal Chemical compound OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 1
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 1
- OCQQATZYCNAKQB-UQUNHUMXSA-N 2-[(2e,6e,10e,14e,18e,22e,26e,30e,34e)-3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaenyl]-3-methylnaphthalene-1,4-dione Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)=C(C)C(=O)C2=C1 OCQQATZYCNAKQB-UQUNHUMXSA-N 0.000 description 1
- JRQRCGAQNZQEJS-WPPIEQSHSA-N 2-[(2e,6e,10e,14e,18e,22e,26e,30e,34e,38e,42e)-3,7,11,15,19,23,27,31,35,39,43,47-dodecamethyloctatetraconta-2,6,10,14,18,22,26,30,34,38,42,46-dodecaenyl]-3-methylnaphthalene-1,4-dione Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)=C(C)C(=O)C2=C1 JRQRCGAQNZQEJS-WPPIEQSHSA-N 0.000 description 1
- YYDMANIEKFAEJC-RYZSZPJESA-N 2-methyl-3-[(2e,6e,10e,14e,18e,22e,26e,30e,34e,38e)-3,7,11,15,19,23,27,31,35,39,43-undecamethyltetratetraconta-2,6,10,14,18,22,26,30,34,38,42-undecaenyl]naphthalene-1,4-dione Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)=C(C)C(=O)C2=C1 YYDMANIEKFAEJC-RYZSZPJESA-N 0.000 description 1
- PZCKKEDSUIYKTM-HWRCDASFSA-N 2-methyl-3-[(2e,6e,10e,14e,18e,22e,26e,30e,34e,38e,42e,46e)-3,7,11,15,19,23,27,31,35,39,43,47,51-tridecamethyldopentaconta-2,6,10,14,18,22,26,30,34,38,42,46,50-tridecaenyl]naphthalene-1,4-dione Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)=C(C)C(=O)C2=C1 PZCKKEDSUIYKTM-HWRCDASFSA-N 0.000 description 1
- PMYDPQQPEAYXKD-UHFFFAOYSA-N 3-hydroxy-n-naphthalen-2-ylnaphthalene-2-carboxamide Chemical compound C1=CC=CC2=CC(NC(=O)C3=CC4=CC=CC=C4C=C3O)=CC=C21 PMYDPQQPEAYXKD-UHFFFAOYSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 244000144725 Amygdalus communis Species 0.000 description 1
- 244000226021 Anacardium occidentale Species 0.000 description 1
- 235000011514 Anogeissus latifolia Nutrition 0.000 description 1
- 244000106483 Anogeissus latifolia Species 0.000 description 1
- 235000017060 Arachis glabrata Nutrition 0.000 description 1
- 244000105624 Arachis hypogaea Species 0.000 description 1
- 235000010777 Arachis hypogaea Nutrition 0.000 description 1
- 235000018262 Arachis monticola Nutrition 0.000 description 1
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 1
- 241000416162 Astragalus gummifer Species 0.000 description 1
- 235000012284 Bertholletia excelsa Nutrition 0.000 description 1
- 244000205479 Bertholletia excelsa Species 0.000 description 1
- 241001134770 Bifidobacterium animalis Species 0.000 description 1
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 1
- 235000004936 Bromus mango Nutrition 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 239000001736 Calcium glycerylphosphate Substances 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 229910021555 Chromium Chloride Inorganic materials 0.000 description 1
- 235000005979 Citrus limon Nutrition 0.000 description 1
- 244000131522 Citrus pyriformis Species 0.000 description 1
- OCUCCJIRFHNWBP-IYEMJOQQSA-L Copper gluconate Chemical compound [Cu+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O OCUCCJIRFHNWBP-IYEMJOQQSA-L 0.000 description 1
- 241000723382 Corylus Species 0.000 description 1
- 235000007466 Corylus avellana Nutrition 0.000 description 1
- 206010011469 Crying Diseases 0.000 description 1
- HJTVQHVGMGKONQ-LUZURFALSA-N Curcumin II Natural products C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=CC(O)=CC=2)=C1 HJTVQHVGMGKONQ-LUZURFALSA-N 0.000 description 1
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
- IELOKBJPULMYRW-NJQVLOCASA-N D-alpha-Tocopheryl Acid Succinate Chemical compound OC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C IELOKBJPULMYRW-NJQVLOCASA-N 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 1
- 206010011971 Decreased interest Diseases 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 235000021298 Dihomo-γ-linolenic acid Nutrition 0.000 description 1
- 235000021294 Docosapentaenoic acid Nutrition 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
- 235000016623 Fragaria vesca Nutrition 0.000 description 1
- 240000009088 Fragaria x ananassa Species 0.000 description 1
- 235000011363 Fragaria x ananassa Nutrition 0.000 description 1
- OPGOLNDOMSBSCW-CLNHMMGSSA-N Fursultiamine hydrochloride Chemical compound Cl.C1CCOC1CSSC(\CCO)=C(/C)N(C=O)CC1=CN=C(C)N=C1N OPGOLNDOMSBSCW-CLNHMMGSSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 229920002148 Gellan gum Polymers 0.000 description 1
- 229920002907 Guar gum Polymers 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 239000001922 Gum ghatti Substances 0.000 description 1
- 229920000569 Gum karaya Polymers 0.000 description 1
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 241000758791 Juglandaceae Species 0.000 description 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
- 102000004407 Lactalbumin Human genes 0.000 description 1
- 108090000942 Lactalbumin Proteins 0.000 description 1
- 229920000161 Locust bean gum Polymers 0.000 description 1
- 235000014826 Mangifera indica Nutrition 0.000 description 1
- 240000007228 Mangifera indica Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 description 1
- 240000008188 Monarda punctata Species 0.000 description 1
- 206010027951 Mood swings Diseases 0.000 description 1
- 240000009023 Myrrhis odorata Species 0.000 description 1
- 235000007265 Myrrhis odorata Nutrition 0.000 description 1
- HSHXDCVZWHOWCS-UHFFFAOYSA-N N'-hexadecylthiophene-2-carbohydrazide Chemical compound CCCCCCCCCCCCCCCCNNC(=O)c1cccs1 HSHXDCVZWHOWCS-UHFFFAOYSA-N 0.000 description 1
- 229930192627 Naphthoquinone Natural products 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- 244000061176 Nicotiana tabacum Species 0.000 description 1
- 108010058846 Ovalbumin Proteins 0.000 description 1
- 206010033664 Panic attack Diseases 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 235000012550 Pimpinella anisum Nutrition 0.000 description 1
- 235000003447 Pistacia vera Nutrition 0.000 description 1
- 240000006711 Pistacia vera Species 0.000 description 1
- 108010064851 Plant Proteins Proteins 0.000 description 1
- 241000282849 Ruminantia Species 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 239000004283 Sodium sorbate Substances 0.000 description 1
- 235000009184 Spondias indica Nutrition 0.000 description 1
- 244000228451 Stevia rebaudiana Species 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- RZCIEJXAILMSQK-JXOAFFINSA-N TTP Chemical compound O=C1NC(=O)C(C)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 RZCIEJXAILMSQK-JXOAFFINSA-N 0.000 description 1
- 235000009470 Theobroma cacao Nutrition 0.000 description 1
- MSCCTZZBYHQMQJ-AZAGJHQNSA-N Tocopheryl nicotinate Chemical compound C([C@@](OC1=C(C)C=2C)(C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)CC1=C(C)C=2OC(=O)C1=CC=CN=C1 MSCCTZZBYHQMQJ-AZAGJHQNSA-N 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- MECHNRXZTMCUDQ-UHFFFAOYSA-N Vitamin D2 Natural products C1CCC2(C)C(C(C)C=CC(C)C(C)C)CCC2C1=CC=C1CC(O)CCC1=C MECHNRXZTMCUDQ-UHFFFAOYSA-N 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 229930003448 Vitamin K Natural products 0.000 description 1
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 235000016127 added sugars Nutrition 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 229940023476 agar Drugs 0.000 description 1
- 235000010419 agar Nutrition 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 150000001447 alkali salts Chemical class 0.000 description 1
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 1
- 229930002945 all-trans-retinaldehyde Natural products 0.000 description 1
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 235000020224 almond Nutrition 0.000 description 1
- 235000020194 almond milk Nutrition 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 230000004596 appetite loss Effects 0.000 description 1
- 235000015197 apple juice Nutrition 0.000 description 1
- 229940002010 banana extract Drugs 0.000 description 1
- OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 description 1
- 239000010620 bay oil Substances 0.000 description 1
- 235000003952 beebalm Nutrition 0.000 description 1
- 235000013734 beta-carotene Nutrition 0.000 description 1
- 239000011648 beta-carotene Substances 0.000 description 1
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 1
- 229960002747 betacarotene Drugs 0.000 description 1
- 229940118852 bifidobacterium animalis Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- JYTVKRNTTALBBZ-UHFFFAOYSA-N bis demethoxycurcumin Natural products C1=CC(O)=CC=C1C=CC(=O)CC(=O)C=CC1=CC=CC(O)=C1 JYTVKRNTTALBBZ-UHFFFAOYSA-N 0.000 description 1
- PREBVFJICNPEKM-YDWXAUTNSA-N bisdemethoxycurcumin Chemical compound C1=CC(O)=CC=C1\C=C\C(=O)CC(=O)\C=C\C1=CC=C(O)C=C1 PREBVFJICNPEKM-YDWXAUTNSA-N 0.000 description 1
- 229910052796 boron Inorganic materials 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 235000020113 brazil nut Nutrition 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 description 1
- 239000001639 calcium acetate Substances 0.000 description 1
- 235000011092 calcium acetate Nutrition 0.000 description 1
- 229960005147 calcium acetate Drugs 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 229960002713 calcium chloride Drugs 0.000 description 1
- 235000011148 calcium chloride Nutrition 0.000 description 1
- 239000001201 calcium disodium ethylene diamine tetra-acetate Substances 0.000 description 1
- 235000011188 calcium disodium ethylene diamine tetraacetate Nutrition 0.000 description 1
- 239000004227 calcium gluconate Substances 0.000 description 1
- 235000013927 calcium gluconate Nutrition 0.000 description 1
- 229960004494 calcium gluconate Drugs 0.000 description 1
- 229940095618 calcium glycerophosphate Drugs 0.000 description 1
- UHHRFSOMMCWGSO-UHFFFAOYSA-L calcium glycerophosphate Chemical compound [Ca+2].OCC(CO)OP([O-])([O-])=O UHHRFSOMMCWGSO-UHFFFAOYSA-L 0.000 description 1
- 235000019299 calcium glycerylphosphate Nutrition 0.000 description 1
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 description 1
- 239000001527 calcium lactate Substances 0.000 description 1
- 235000011086 calcium lactate Nutrition 0.000 description 1
- 229960002401 calcium lactate Drugs 0.000 description 1
- 229940095672 calcium sulfate Drugs 0.000 description 1
- 235000011132 calcium sulphate Nutrition 0.000 description 1
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 description 1
- SHWNNYZBHZIQQV-UHFFFAOYSA-L calcium;disodium;2-[2-[bis(carboxylatomethyl)azaniumyl]ethyl-(carboxylatomethyl)azaniumyl]acetate Chemical compound [Na+].[Na+].[Ca+2].[O-]C(=O)C[NH+](CC([O-])=O)CC[NH+](CC([O-])=O)CC([O-])=O SHWNNYZBHZIQQV-UHFFFAOYSA-L 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000020258 cashew milk Nutrition 0.000 description 1
- 235000020226 cashew nut Nutrition 0.000 description 1
- 239000010627 cedar oil Substances 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 229920006184 cellulose methylcellulose Polymers 0.000 description 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
- 229960001231 choline Drugs 0.000 description 1
- 229940046374 chromium picolinate Drugs 0.000 description 1
- QSWDMMVNRMROPK-UHFFFAOYSA-K chromium(3+) trichloride Chemical compound [Cl-].[Cl-].[Cl-].[Cr+3] QSWDMMVNRMROPK-UHFFFAOYSA-K 0.000 description 1
- GJYSUGXFENSLOO-UHFFFAOYSA-N chromium;pyridine-2-carboxylic acid Chemical compound [Cr].OC(=O)C1=CC=CC=N1.OC(=O)C1=CC=CC=N1.OC(=O)C1=CC=CC=N1 GJYSUGXFENSLOO-UHFFFAOYSA-N 0.000 description 1
- 239000010630 cinnamon oil Substances 0.000 description 1
- 239000001926 citrus aurantium l. subsp. bergamia wright et arn. oil Substances 0.000 description 1
- 239000010634 clove oil Substances 0.000 description 1
- 239000011789 cobamamide Substances 0.000 description 1
- 235000006279 cobamamide Nutrition 0.000 description 1
- ZIHHMGTYZOSFRC-UWWAPWIJSA-M cobamamide Chemical compound C1(/[C@](C)(CCC(=O)NC[C@H](C)OP(O)(=O)OC2[C@H]([C@H](O[C@@H]2CO)N2C3=CC(C)=C(C)C=C3N=C2)O)[C@@H](CC(N)=O)[C@]2(N1[Co+]C[C@@H]1[C@H]([C@@H](O)[C@@H](O1)N1C3=NC=NC(N)=C3N=C1)O)[H])=C(C)\C([C@H](C/1(C)C)CCC(N)=O)=N\C\1=C/C([C@H]([C@@]\1(CC(N)=O)C)CCC(N)=O)=N/C/1=C(C)\C1=N[C@]2(C)[C@@](C)(CC(N)=O)[C@@H]1CCC(N)=O ZIHHMGTYZOSFRC-UWWAPWIJSA-M 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 229940108925 copper gluconate Drugs 0.000 description 1
- 229960000355 copper sulfate Drugs 0.000 description 1
- 229910000366 copper(II) sulfate Inorganic materials 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 239000011666 cyanocobalamin Substances 0.000 description 1
- 235000000639 cyanocobalamin Nutrition 0.000 description 1
- 229960002104 cyanocobalamin Drugs 0.000 description 1
- 230000001086 cytosolic effect Effects 0.000 description 1
- 229940099418 d- alpha-tocopherol succinate Drugs 0.000 description 1
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 1
- NMRUIRRIQNAQEB-UHFFFAOYSA-N demethoxycurcumin Natural products OC(=CC(C=CC1=CC(=C(C=C1)O)OC)=O)C=CC1=CC=C(C=C1)O NMRUIRRIQNAQEB-UHFFFAOYSA-N 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- YXAKCQIIROBKOP-UHFFFAOYSA-N di-p-hydroxycinnamoylmethane Natural products C=1C=C(O)C=CC=1C=CC(=O)C=C(O)C=CC1=CC=C(O)C=C1 YXAKCQIIROBKOP-UHFFFAOYSA-N 0.000 description 1
- HOBAELRKJCKHQD-QNEBEIHSSA-N dihomo-γ-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCCCC(O)=O HOBAELRKJCKHQD-QNEBEIHSSA-N 0.000 description 1
- 235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 description 1
- BVTBRVFYZUCAKH-UHFFFAOYSA-L disodium selenite Chemical compound [Na+].[Na+].[O-][Se]([O-])=O BVTBRVFYZUCAKH-UHFFFAOYSA-L 0.000 description 1
- 229960000878 docusate sodium Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 235000013345 egg yolk Nutrition 0.000 description 1
- 210000002969 egg yolk Anatomy 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- IQLUYYHUNSSHIY-HZUMYPAESA-N eicosatetraenoic acid Chemical compound CCCCCCCCCCC\C=C\C=C\C=C\C=C\C(O)=O IQLUYYHUNSSHIY-HZUMYPAESA-N 0.000 description 1
- 229960002061 ergocalciferol Drugs 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 206010016256 fatigue Diseases 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- 239000011706 ferric diphosphate Substances 0.000 description 1
- 235000007144 ferric diphosphate Nutrition 0.000 description 1
- CADNYOZXMIKYPR-UHFFFAOYSA-B ferric pyrophosphate Chemical compound [Fe+3].[Fe+3].[Fe+3].[Fe+3].[O-]P([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])([O-])=O CADNYOZXMIKYPR-UHFFFAOYSA-B 0.000 description 1
- 229940036404 ferric pyrophosphate Drugs 0.000 description 1
- 229960001781 ferrous sulfate Drugs 0.000 description 1
- 235000021323 fish oil Nutrition 0.000 description 1
- VWWQXMAJTJZDQX-UYBVJOGSSA-N flavin adenine dinucleotide Chemical compound C1=NC2=C(N)N=CN=C2N1[C@@H]([C@H](O)[C@@H]1O)O[C@@H]1CO[P@](O)(=O)O[P@@](O)(=O)OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C2=NC(=O)NC(=O)C2=NC2=C1C=C(C)C(C)=C2 VWWQXMAJTJZDQX-UYBVJOGSSA-N 0.000 description 1
- 229940013640 flavin mononucleotide Drugs 0.000 description 1
- 229940093632 flavin-adenine dinucleotide Drugs 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 229940064302 folacin Drugs 0.000 description 1
- 229940014144 folate Drugs 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 229940098330 gamma linoleic acid Drugs 0.000 description 1
- 235000020664 gamma-linolenic acid Nutrition 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 229960002733 gamolenic acid Drugs 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 235000010492 gellan gum Nutrition 0.000 description 1
- 239000000216 gellan gum Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 235000019674 grape juice Nutrition 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
- 229960002154 guar gum Drugs 0.000 description 1
- 235000019314 gum ghatti Nutrition 0.000 description 1
- 235000020259 hazelnut milk Nutrition 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- DQOCFCZRZOAIBN-WZHZPDAFSA-L hydroxycobalamin Chemical compound O.[Co+2].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O DQOCFCZRZOAIBN-WZHZPDAFSA-L 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 229960000367 inositol Drugs 0.000 description 1
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 235000010494 karaya gum Nutrition 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 235000020778 linoleic acid Nutrition 0.000 description 1
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 1
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 description 1
- 235000014666 liquid concentrate Nutrition 0.000 description 1
- 235000010420 locust bean gum Nutrition 0.000 description 1
- 239000000711 locust bean gum Substances 0.000 description 1
- 150000004668 long chain fatty acids Chemical class 0.000 description 1
- 235000021266 loss of appetite Nutrition 0.000 description 1
- 208000019017 loss of appetite Diseases 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 description 1
- 239000000347 magnesium hydroxide Substances 0.000 description 1
- 229910001862 magnesium hydroxide Inorganic materials 0.000 description 1
- 239000000395 magnesium oxide Substances 0.000 description 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
- GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 description 1
- 239000004137 magnesium phosphate Substances 0.000 description 1
- 229960002261 magnesium phosphate Drugs 0.000 description 1
- 229910000157 magnesium phosphate Inorganic materials 0.000 description 1
- 235000010994 magnesium phosphates Nutrition 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
- 229940099596 manganese sulfate Drugs 0.000 description 1
- 239000011702 manganese sulphate Substances 0.000 description 1
- 235000007079 manganese sulphate Nutrition 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- SQQMAOCOWKFBNP-UHFFFAOYSA-L manganese(II) sulfate Chemical compound [Mn+2].[O-]S([O-])(=O)=O SQQMAOCOWKFBNP-UHFFFAOYSA-L 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 239000011676 menaquinone-4 Substances 0.000 description 1
- 239000011700 menaquinone-7 Substances 0.000 description 1
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 239000011585 methylcobalamin Substances 0.000 description 1
- JEWJRMKHSMTXPP-BYFNXCQMSA-M methylcobalamin Chemical compound C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O JEWJRMKHSMTXPP-BYFNXCQMSA-M 0.000 description 1
- 235000007672 methylcobalamin Nutrition 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 229910052750 molybdenum Inorganic materials 0.000 description 1
- 239000011733 molybdenum Substances 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- 150000002791 naphthoquinones Chemical class 0.000 description 1
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 1
- JOUIQRNQJGXQDC-ZYUZMQFOSA-L nicotinate D-ribonucleotide(2-) Chemical compound O1[C@H](COP([O-])([O-])=O)[C@@H](O)[C@@H](O)[C@@H]1[N+]1=CC=CC(C([O-])=O)=C1 JOUIQRNQJGXQDC-ZYUZMQFOSA-L 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 235000015205 orange juice Nutrition 0.000 description 1
- 229940092253 ovalbumin Drugs 0.000 description 1
- UEPVWRDHSPMIAZ-UHFFFAOYSA-N p-hydroxycinnamoyl feruloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(O)=CC(=O)C=CC=2C=CC(O)=CC=2)=C1 UEPVWRDHSPMIAZ-UHFFFAOYSA-N 0.000 description 1
- 208000019906 panic disease Diseases 0.000 description 1
- 229940101267 panthenol Drugs 0.000 description 1
- 229940014662 pantothenate Drugs 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 235000020957 pantothenol Nutrition 0.000 description 1
- 239000011619 pantothenol Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000007918 pathogenicity Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- 235000020265 peanut milk Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000020737 peppermint extract Nutrition 0.000 description 1
- 235000019477 peppermint oil Nutrition 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 description 1
- 229940013712 pineapple extract Drugs 0.000 description 1
- 235000013997 pineapple juice Nutrition 0.000 description 1
- 235000020233 pistachio Nutrition 0.000 description 1
- 235000020260 pistachio milk Nutrition 0.000 description 1
- 235000021118 plant-derived protein Nutrition 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 235000011056 potassium acetate Nutrition 0.000 description 1
- 239000004300 potassium benzoate Substances 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 235000010235 potassium benzoate Nutrition 0.000 description 1
- 229940103091 potassium benzoate Drugs 0.000 description 1
- 229960002816 potassium chloride Drugs 0.000 description 1
- 229940093916 potassium phosphate Drugs 0.000 description 1
- 239000004302 potassium sorbate Substances 0.000 description 1
- 235000010241 potassium sorbate Nutrition 0.000 description 1
- 229940069338 potassium sorbate Drugs 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001902 propagating effect Effects 0.000 description 1
- 229960003581 pyridoxal Drugs 0.000 description 1
- 239000011674 pyridoxal Substances 0.000 description 1
- 235000008164 pyridoxal Nutrition 0.000 description 1
- 239000011699 pyridoxamine Substances 0.000 description 1
- 235000008151 pyridoxamine Nutrition 0.000 description 1
- 239000011677 pyridoxine Substances 0.000 description 1
- 235000008160 pyridoxine Nutrition 0.000 description 1
- 239000011764 pyridoxine hydrochloride Substances 0.000 description 1
- 229960004172 pyridoxine hydrochloride Drugs 0.000 description 1
- 235000019171 pyridoxine hydrochloride Nutrition 0.000 description 1
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 230000002207 retinal effect Effects 0.000 description 1
- NCYCYZXNIZJOKI-OVSJKPMPSA-N retinal group Chemical group C\C(=C/C=O)\C=C\C=C(\C=C\C1=C(CCCC1(C)C)C)/C NCYCYZXNIZJOKI-OVSJKPMPSA-N 0.000 description 1
- 229930002330 retinoic acid Natural products 0.000 description 1
- 229960000342 retinol acetate Drugs 0.000 description 1
- 235000019173 retinyl acetate Nutrition 0.000 description 1
- 239000011770 retinyl acetate Substances 0.000 description 1
- 125000000946 retinyl group Chemical group [H]C([*])([H])/C([H])=C(C([H])([H])[H])/C([H])=C([H])/C([H])=C(C([H])([H])[H])/C([H])=C([H])/C1=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 229940108325 retinyl palmitate Drugs 0.000 description 1
- 235000019172 retinyl palmitate Nutrition 0.000 description 1
- 239000011769 retinyl palmitate Substances 0.000 description 1
- 235000019192 riboflavin Nutrition 0.000 description 1
- 239000002151 riboflavin Substances 0.000 description 1
- 235000015067 sauces Nutrition 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 229940091258 selenium supplement Drugs 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 229960003885 sodium benzoate Drugs 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 229960001790 sodium citrate Drugs 0.000 description 1
- 235000011083 sodium citrates Nutrition 0.000 description 1
- APSBXTVYXVQYAB-UHFFFAOYSA-M sodium docusate Chemical compound [Na+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC APSBXTVYXVQYAB-UHFFFAOYSA-M 0.000 description 1
- 239000011684 sodium molybdate Substances 0.000 description 1
- 235000015393 sodium molybdate Nutrition 0.000 description 1
- TVXXNOYZHKPKGW-UHFFFAOYSA-N sodium molybdate (anhydrous) Chemical compound [Na+].[Na+].[O-][Mo]([O-])(=O)=O TVXXNOYZHKPKGW-UHFFFAOYSA-N 0.000 description 1
- 239000011655 sodium selenate Substances 0.000 description 1
- 235000018716 sodium selenate Nutrition 0.000 description 1
- 229960001881 sodium selenate Drugs 0.000 description 1
- 239000011781 sodium selenite Substances 0.000 description 1
- 235000015921 sodium selenite Nutrition 0.000 description 1
- 229960001471 sodium selenite Drugs 0.000 description 1
- LROWVYNUWKVTCU-STWYSWDKSA-M sodium sorbate Chemical compound [Na+].C\C=C\C=C\C([O-])=O LROWVYNUWKVTCU-STWYSWDKSA-M 0.000 description 1
- 235000019250 sodium sorbate Nutrition 0.000 description 1
- 235000013322 soy milk Nutrition 0.000 description 1
- JIWBIWFOSCKQMA-UHFFFAOYSA-N stearidonic acid Natural products CCC=CCC=CCC=CCC=CCCCCC(O)=O JIWBIWFOSCKQMA-UHFFFAOYSA-N 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 235000019157 thiamine Nutrition 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- 239000011721 thiamine Substances 0.000 description 1
- 239000011747 thiamine hydrochloride Substances 0.000 description 1
- 229960000344 thiamine hydrochloride Drugs 0.000 description 1
- 235000019190 thiamine hydrochloride Nutrition 0.000 description 1
- 239000011748 thiamine mononitrate Substances 0.000 description 1
- UIERGBJEBXXIGO-UHFFFAOYSA-N thiamine mononitrate Chemical compound [O-][N+]([O-])=O.CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N UIERGBJEBXXIGO-UHFFFAOYSA-N 0.000 description 1
- 229960004860 thiamine mononitrate Drugs 0.000 description 1
- 235000019191 thiamine mononitrate Nutrition 0.000 description 1
- 229960002363 thiamine pyrophosphate Drugs 0.000 description 1
- AYEKOFBPNLCAJY-UHFFFAOYSA-O thiamine pyrophosphate Chemical compound CC1=C(CCOP(O)(=O)OP(O)(O)=O)SC=[N+]1CC1=CN=C(C)N=C1N AYEKOFBPNLCAJY-UHFFFAOYSA-O 0.000 description 1
- IWLROWZYZPNOFC-UHFFFAOYSA-O thiamine triphosphate Chemical compound CC1=C(CCOP(O)(=O)OP(O)(=O)OP(O)(O)=O)SC=[N+]1CC1=CN=C(C)N=C1N IWLROWZYZPNOFC-UHFFFAOYSA-O 0.000 description 1
- YXVCLPJQTZXJLH-UHFFFAOYSA-N thiamine(1+) diphosphate chloride Chemical compound [Cl-].CC1=C(CCOP(O)(=O)OP(O)(O)=O)SC=[N+]1CC1=CN=C(C)N=C1N YXVCLPJQTZXJLH-UHFFFAOYSA-N 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- 229950009883 tocopheryl nicotinate Drugs 0.000 description 1
- 235000015149 toffees Nutrition 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 229960001727 tretinoin Drugs 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 1
- 239000011691 vitamin B1 Substances 0.000 description 1
- 239000011715 vitamin B12 Substances 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 description 1
- 235000001892 vitamin D2 Nutrition 0.000 description 1
- 239000011653 vitamin D2 Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
- 150000003721 vitamin K derivatives Chemical class 0.000 description 1
- 239000011728 vitamin K2 Substances 0.000 description 1
- 239000011652 vitamin K3 Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 229940046010 vitamin k Drugs 0.000 description 1
- 235000020234 walnut Nutrition 0.000 description 1
- 235000020261 walnut milk Nutrition 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- 235000021241 α-lactalbumin Nutrition 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7016—Disaccharides, e.g. lactose, lactulose
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C11/00—Milk substitutes, e.g. coffee whitener compositions
- A23C11/02—Milk substitutes, e.g. coffee whitener compositions containing at least one non-milk component as source of fats or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C11/00—Milk substitutes, e.g. coffee whitener compositions
- A23C11/02—Milk substitutes, e.g. coffee whitener compositions containing at least one non-milk component as source of fats or proteins
- A23C11/10—Milk substitutes, e.g. coffee whitener compositions containing at least one non-milk component as source of fats or proteins containing or not lactose but no other milk components as source of fats, carbohydrates or proteins
- A23C11/103—Milk substitutes, e.g. coffee whitener compositions containing at least one non-milk component as source of fats or proteins containing or not lactose but no other milk components as source of fats, carbohydrates or proteins containing only proteins from pulses, oilseeds or nuts, e.g. nut milk
- A23C11/106—Addition of, or treatment with, microorganisms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
- A23C9/13—Fermented milk preparations; Treatment using microorganisms or enzymes using additives
- A23C9/1307—Milk products or derivatives; Fruit or vegetable juices; Sugars, sugar alcohols, sweeteners; Oligosaccharides; Organic acids or salts thereof or acidifying agents; Flavours, dyes or pigments; Inert or aerosol gases; Carbonation methods
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
- A23C9/13—Fermented milk preparations; Treatment using microorganisms or enzymes using additives
- A23C9/1315—Non-milk proteins or fats; Seeds, pulses, cereals or soja; Fatty acids, phospholipids, mono- or diglycerides or derivatives therefrom; Egg products
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
- A23C9/13—Fermented milk preparations; Treatment using microorganisms or enzymes using additives
- A23C9/1322—Inorganic compounds; Minerals, including organic salts thereof, oligo-elements; Amino-acids, peptides, protein-hydrolysates or derivatives; Nucleic acids or derivatives; Yeast extract or autolysate; Vitamins; Antibiotics; Bacteriocins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
- A23C9/13—Fermented milk preparations; Treatment using microorganisms or enzymes using additives
- A23C9/133—Fruit or vegetables
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/1528—Fatty acids; Mono- or diglycerides; Petroleum jelly; Paraffine; Phospholipids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/156—Flavoured milk preparations ; Addition of fruits, vegetables, sugars, sugar alcohols or sweeteners
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/158—Milk preparations; Milk powder or milk powder preparations containing additives containing vitamins or antibiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/20—Dietetic milk products not covered by groups A23C9/12 - A23C9/18
- A23C9/203—Dietetic milk products not covered by groups A23C9/12 - A23C9/18 containing bifidus-active substances, e.g. lactulose; containing oligosaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A23L33/155—Vitamins A or D
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/175—Rhamnosus
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Botany (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biophysics (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Pediatric Medicine (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physiology (AREA)
- Zoology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
Abstract
本公开通常涉及用于促进或维持产后产妇健康的方法和营养组合物。所述营养组合物可以包含唾液乳糖、长链多不饱和脂肪酸(“LCPUFA”)的源、益生菌(如鼠李糖乳杆菌(Lactobacillus rhamnosus)GG(LGG))、坚果提取物、姜黄、胡芦巴钙和/或维生素D。所述营养组合物适合给予产后母亲。另外,本公开提供了用于预防产后抑郁和/或焦虑或降低产后抑郁和/或焦虑的严重程度的方法。本文提供的一种或多种营养组合物可以包含为产后母亲提供累加和/或协同有益健康效果的成分的各种组合。
Description
技术领域
本公开通常涉及用于促进或维持产后产妇健康的方法和营养组合物。所述营养组合物可以包含唾液乳糖(例如,3'唾液乳糖和6'唾液乳糖)、长链多不饱和脂肪酸(“LCPUFA”)的源、益生菌(如鼠李糖乳杆菌(Lactobacillus rhamnosus) GG (LGG))、坚果提取物、姜黄、胡芦巴钙和/或维生素D。所述营养组合物适合给予产后母亲。另外,本公开提供了用于预防产后抑郁和/或焦虑或降低产后抑郁和/或焦虑的严重程度的方法。本文提供的一种或多种营养组合物可以包含为产后母亲提供累加和/或协同有益健康效果的成分的各种组合。
背景技术
母亲在婴儿出生后的需求是广泛的。新母亲面临着许多挑战,包括从出生起的愈合、激素水平的剧烈波动、频繁的母乳喂养和睡眠缺乏。母亲在产后期可能难以维持其自身健康并且特别是消耗满足母乳喂养的营养需求所必需的营养。此外,7个妇女中约有1个经历产后抑郁和/或焦虑。
因此,在本领域中需要一种新母亲可以在忙碌时或在多任务处理时消费的营养补充物,其支持母亲的健康,而对于她毫不费力。
发明内容
本文描述了用于促进或维持产后产妇健康的方法和营养组合物。所述营养组合物可以包含唾液乳糖(例如,3'唾液乳糖和6'唾液乳糖)、长链多不饱和脂肪酸(“LCPUFA”)的源、益生菌(如鼠李糖乳杆菌GG (LGG))、坚果提取物、姜黄、胡芦巴钙和/或维生素D。所述营养组合物适合给予产后母亲以增加或维持母亲的健康。
另外,本公开提供了用于预防产后抑郁和/或焦虑或降低产后抑郁和/或焦虑的严重程度的方法。本文提供的一种或多种营养组合物可以包含为产后母亲提供累加和/或协同有益健康效果的成分的各种组合。特别地,唾液乳糖和/或DHA的使用可以预防产后母亲的产后抑郁和/或焦虑或降低产后母亲的产后抑郁和/或焦虑的严重程度。
一方面,本公开涉及用于支持产后母亲健康的营养组合物,其包含唾液乳糖、长链多不饱和脂肪酸(LCPUFA)和益生菌。在某些实施方案中,营养组合物还包含胡芦巴、姜黄、坚果提取物、钙、维生素D中的一种或多种。例如,对于母乳喂养的产后母亲,营养组合物可以包含唾液乳糖、LCPUFA、益生菌、胡芦巴、姜黄和/或其他香料、坚果或坚果提取物、钙和维生素D。在其他实施方案中,例如,对于非母乳喂养的产后母亲,营养组合物可以包含唾液乳糖、LCPUFA、益生菌、姜黄、钙和维生素D。
在某些实施方案中,唾液乳糖以每份营养组合物约7 g至约10 g的量存在。在某些实施方案中,唾液乳糖包括3'-唾液乳糖(3'-SL)和/或6'-唾液乳糖(6'-SL)。
在某些实施方案中,LCPUFA以每份营养组合物约150 mg至约200 mg的量存在。例如,LCPUFA可以约50 mg至约500 mg、约100 mg至约400 mg、约150 mg至约350 mg或约200mg至约300 mg的量存在。合适的LCPUFA包括但不限于α-亚油酸、γ-亚油酸、亚油酸、亚麻酸、二十二碳六烯酸(DHA)、二十碳五烯酸(EPA)和花生四烯酸(ARA)。
在某些实施方案中,LCPUFA包括二十二碳六烯酸(DHA)。例如,DHA可以约50 mg至500 mg、约100 mg至400 mg、约150 mg至350 mg或约200 mg至300 mg的量存在。
在某些实施方案中,益生菌以每份营养组合物至多约1.5×1010 cfu的量存在。例如,益生菌可以约1.5×109至1.5×1010之间的量存在。在某些实施方案中,益生菌包括鼠李糖乳杆菌GG (LGG)。
在某些实施方案中,胡芦巴以每份营养组合物至多约1500 mg的量存在。
在某些实施方案中,姜黄以足以供应每份营养组合物约50 mg总姜黄色素(curcuminoid)的量存在。
在某些实施方案中,钙以每份营养组合物约500 mg至约1000 mg的量存在。在某些实施方案中,维生素D以每份营养组合物约800 IU至约1000 IU的量存在。
在某些实施方案中,营养组合物以液体形式,例如,乳基饮品、果汁基饮品或坚果乳基饮品。在某些实施方案中,乳基饮品是酸奶饮品。例如,所述液体可以包装成7-8盎司份。在其他实施方案中,营养组合物以粉末形式。
在另一方面,本公开涉及支持产后母亲的健康的方法。所述方法包括向母亲提供或给予任何上述营养组合物。
在另一方面,本公开涉及预防产后母亲的产后抑郁和/或焦虑或降低产后母亲的产后抑郁和/或焦虑的严重程度的方法,所述方法包括向母亲提供或给予任何上述营养组合物。
应当理解,前面的一般性描述和以下的详细描述两者都呈现了本公开的实施方案,并且旨在提供用于理解要求保护的本公开的性质和特性的概述或框架。所述描述用于解释所要求保护的主题的原理和操作。通过阅读以下公开内容,本领域技术人员将容易明白本公开的其他和另外的特点和优点。
具体实施方式
现在将详细参考本公开的实施方案,其一个或多个实例在下文中阐述。每个实例通过解释本公开的营养组合物提供,并且不是限制。实际上,对于本领域技术人员显而易见的是,在不脱离本公开的范围的情况下,可以对本公开的教导进行各种修改和变化。例如,作为一个实施方案的一部分说明或描述的特点可以与另一实施方案一起使用以产生又一个实施方案。
因此,本公开旨在涵盖落入所附权利要求及其等同物的范围内的这样的修改和变化。本公开的其他目的、特点和方面在以下详细描述中公开或显而易见。本领域普通技术人员应理解,本讨论仅是示例性实施方案的描述,并不意图限制本公开的更广泛方面。
本公开一般涉及用于支持产后母亲健康的营养组合物和方法。在某些实施方案中,本文所述的营养组合物用于向产后母亲提供营养。本公开还涉及用于预防产后母亲的产后抑郁和/或焦虑或降低产后母亲的产后抑郁和/或焦虑的严重程度的营养组合物和方法。在其他实施方案中,本公开涉及制备如本文所述的营养组合物的方法,所述方法包括组合一种或多种本文所述的组分。
“营养组合物”意指满足产后母亲的营养需求的至少一部分的物质或制剂。术语“一种或多种营养物”、“一种或多种营养配方食品”、“一种或多种肠营养物”和“一种或多种营养补充物”用作整个本公开的一种或多种营养组合物的非限制性实例。此外,“一种或多种营养组合物”可以指液体、粉末、凝胶、糊剂、固体、浓缩物、混悬剂或即用形式的口服配方食品(即,饮品)。
“营养完全”意指可以用作唯一营养来源的组合物,其将与蛋白质、碳水化合物和脂质组合,基本上供应所有每日所需量的维生素、矿物质和/或微量元素。
本公开的营养组合物可以基本上不含本文所述的任何任选或选择的成分,条件是剩余的营养组合物仍含有本文所述的所有所需成分或特点。在本文中,并且除非另有说明,否则术语“基本上不含”意指所选择的组合物可以含有少于功能量的任选成分,通常小于0.1重量%,并且还包括0重量%的这样的任选或选择的成分。
当应用于营养时,术语“必需”是指身体不能以足以维持健康的量合成,并且因此必须由饮食供应的任何营养。应用于营养的术语“条件必需”意指在不能使身体获得足够量的前体化合物以发生内源性合成的条件下必须由饮食供应营养。
“产后母亲”意指最近分娩了婴儿(例如,一个或多个婴儿)的妇女。在某些实施方案中,产后母亲是在此之前五年内分娩过婴儿的母亲。在某些实施方案中,产后母亲是在此之前三年内分娩过的母亲。在某些实施方案中,产后母亲是在此之前两年内分娩过的母亲。在某些实施方案中,产后母亲是在此之前一年内分娩过的母亲。在某些实施方案中,产后母亲是在此之前6个月内分娩过的母亲。在某些实施方案中,产后母亲是在此之前3个月内分娩过的母亲。在某些实施方案中,产后母亲是在此之前6周内分娩过的母亲。在某些实施方案中,任何母乳喂养的母亲都可以被认为是产后母亲。
“产后抑郁和/或焦虑”是本领域理解的术语,意指婴儿出生之后发生的临床抑郁。预防产后抑郁或降低产后抑郁的严重程度意指预防产后抑郁的一种或多种症状或降低产后抑郁的一种或多种症状的严重程度,所述症状包括愤怒、焦虑、内疚、绝望、活动中的兴趣或快感丧失、情绪波动、惊恐发作、疲劳、食欲丧失、烦躁、抑郁、恐惧、反复思考、哭泣、易怒、注意力分散、多余想法和失眠。
“益生菌”意指具有低致病性或无致病性的微生物,其对宿主的健康发挥至少一种有益作用。益生菌的一个实例是LGG。
在一个实施方案中,一种或多种益生菌可以为存活的或非存活的。如本文所用,术语“存活的”是指活的微生物。术语“非存活的”或“非存活的益生菌”意指非活的益生菌微生物、其细胞组分和/或其代谢物。这样的非存活的益生菌可能已被热杀死或以其他方式失活,但它们保留有利地影响宿主的健康的能力。本公开中可用的益生菌可以为天然存在的、通过生物体的基因操作合成或开发的,不管这样的来源现在是已知的还是之后开发的。
术语“失活的益生菌”意指其中所提及的益生菌生物体的代谢活性或繁殖能力已被降低或破坏的益生菌。然而,“失活的益生菌”确实仍然在细胞水平上保留其生物学二醇-蛋白质和DNA/RNA结构的至少一部分。如本文所用,术语“失活的”与“非存活的”同义。更具体地,失活的益生菌的一个非限制性实例是失活的鼠李糖乳杆菌GG(“LGG”)或“失活的LGG”。
术语“细胞当量”是指等同于同等数量的存活的细胞的非存活的非繁殖性益生菌的水平。术语“非繁殖性”应理解为自相同量的繁殖菌获得的非繁殖性微生物的量(cfu/g),所述非繁殖性微生物包括失活的益生菌、DNA片段、细胞壁或胞质化合物。换句话说,非存活的非繁殖性生物体的量以cfu的方式表示,如同所有微生物都是活的一样,不管它们是否是死的、非繁殖性的、失活的、片段化的等。
除非另有说明,否则如本文所用的所有百分比、份数和比率均以总组合物的重量计。
除非另有说明或通过其中进行引用的上下文清楚地暗示相反情况,否则对本公开的单数特征或限制的所有引用都应包括相应的复数特征或限制,反之亦然。
除非另有说明或通过其中进行引用的组合的上下文清楚地暗示相反情况,否则本文所用的方法或工艺步骤的所有组合可以以任何顺序执行。
本公开的方法和组合物,包括其组分,可以包含本文所述的实施方案的基本要素和限制以及本文所述的任何另外或任选的成分、组分或限制或可用于营养组合物中的其他物质,由其组成或基本上由其组成。
如本文所用,术语“约”应解释为是指指定为任何范围的一个或多个端点的两个数字。对范围的任何提及都应被视为为该范围内的任何子集提供支持。
本文所述的营养组合物的每种成分的量是基于每份测量的。一份可以是约7盎司至约8盎司和/或约1500 kcal至约3000 kcal。
本文公开的营养组合物可以含有唾液乳糖。用于本文的组合物和方法的唾液乳糖的合适形式包括3'-唾液乳糖(3'-SL)和/或6'-唾液乳糖(6'-SL)。
唾液乳糖可以从乳制品中纯化,如美国专利号8,445,053中所述。乳制品可以是源自反刍动物或另一种产奶动物的奶或任何乳制品。乳制品可以例如是牛乳清制品,如乳清保留物或乳清渗透物。乳制品也可以是来自从乳清制备乳糖的母液。还可以使用乳渗透物、乳保留物、分馏的乳保留物或任何其他含有唾液乳糖的乳制品。唾液乳糖也可以如美国专利号8,507,227和9,637,768中所述合成。唾液乳糖可以从商业来源获得,例如Arla FoodsInc., Basking Ridge, NJ或Jennewein Biotechnology GmbH, Rheinbreitbach,Germany。
在某些实施方案中,唾液乳糖以每份营养组合物约7 g至约10 g的量存在。在某些实施方案中,唾液乳糖以约8 g至约10 g、约8 g至约9 g、约9 g至约10 g、约7 g、约8 g、约9g或约10 g的量存在。
在一些实施方案中,营养组合物还可以包括LCPUFA的源。LCPUFA的非限制性实例包括但不限于DHA、ARA、亚油酸(18:2 n-6)、γ-亚麻酸(18:3 n-6)、n-6途径中的二高-γ-亚麻酸(20:3 n-6)、α-亚麻酸(18:3 n-3)、十八碳四烯酸(18:4 n-3)、二十碳四烯酸(20:4n-3)、二十碳五烯酸(20:5 n-3)和二十二碳五烯酸(22:6 n-3)。在一个实施方案中,营养组合物中LCPUFA的量为每份至少约150 mg。LCPUFA的量可以从每份约150 mg至每份约200mg,每份约160 mg至每份约190 mg,或每份约170 mg至每份约180 mg变化。
在一些实施方案中,营养组合物中包含的LCPUFA可以包含DHA。如果包含的话,DHA和/或ARA的源可以是本领域已知的任何来源,例如海洋油、鱼油、单细胞油、蛋黄脂质和脑脂质。在一些实施方案中,DHA和ARA来源于单细胞Martek油、DHASCO®和ARASCO®或其变体。DHA和ARA可以呈天然形式,条件是LCPUFA的源的其余部分不会对产后母亲产生任何实质性的有害影响。或者,DHA和ARA可以以精制形式使用。
在一个实施方案中,DHA和ARA的源是单细胞油,如美国专利号5,374,657;5,550,156;和5,397,591中所教导,这些美国专利的公开内容通过引用以其整体并入本文。然而,本公开不仅仅限于这样的油。
在一个实施方案中,营养组合物中DHA的量为每份至少约150 mg。DHA的量可以从每份约150 mg至约200 mg、每份约160 mg至约190 mg、每份约170 mg至约180 mg、每份约150 mg至约190 mg、每份约150 mg至约180 mg、每份约150 mg至约170 mg、每份约160 mg至约200 mg、每份约170 mg至约200 mg、每份约180 mg至约200 mg变化。
在一些实施方案中,营养组合物的益生菌包含鼠李糖乳杆菌GG (ATCC号53103)。在其他实施方案中,本文所述的公开的一种或多种营养组合物可以包含不同于LGG、除LGG之外或代替LGG的益生菌。可以包含在营养组合物中的另外的益生菌包括但不限于:双歧杆菌属(Bifidobacterium)物种、长双歧杆菌(Bifidobacterium longum) BB536 (BL999,ATCC:BAA-999)、长双歧杆菌AH 1206 (NCIMB:41382)、短双歧杆菌(Bifidobacterium breve) AH1205 (NCIMB:41387)、婴儿双歧杆菌(Bifidobacterium infantis)35624(NCIMB:41003)和动物双歧杆菌乳酸亚种(Bifidobacterium animalis subsp. lactis)BB-12 (DSM号10140)或其任何组合。
在一些实施方案中,营养组合物包含以每份至多约1.5×1010的量的益生菌(如LGG)。在其他实施方案中,营养组合物包含以约1×106 cfu/100 kcal至约1×109 cfu/100kcal的量的益生菌。此外,在某些实施方案中,营养组合物可以包含以约1×107 cfu/100kcal至约1×108 cfu/100 kcal的量的益生菌。
在某些实施方案中,胡芦巴包含在所述组合物中。胡芦巴特别可用于包含在母乳喂养的产后母亲的营养组合物中,因为已知其刺激产奶。胡芦巴可以每份组合物至多1500mg的量添加。例如,胡芦巴可以以约0.1 mg至约1500 mg、约1 mg至约1500 mg、约1 mg至约1000 mg、约10 mg至约1500 mg、约10 mg至约1000 mg、约50 mg至约1500 mg、约50 mg至约1000 mg、约100 mg至约1500 mg或约100 mg至约1000 mg的量存在。
在某些实施方案中,姜黄包含在所述组合物中。姜黄的抗炎性质可以用于产后母亲。姜黄含有姜黄色素化合物,例如姜黄素(curcumin)、脱甲氧基姜黄素和双脱甲氧基姜黄素。姜黄可以以提供每份组合物至多约50 mg总姜黄色素的量添加。在某些实施方案中,营养组合物包含足以每份约0.1 mg至约50 mg总姜黄色素、每份约1 mg至约50 mg总姜黄色素、每份约5 mg至约50 mg总姜黄色素或每份约25 mg至约50 mg姜黄色素的量的姜黄。
在某些实施方案中,坚果或坚果提取物包含在组合物中。最近的证据表明,在早年食用坚果可以防止婴儿的坚果过敏。(参见,Du Toit等人,(2015) “Randomized Trial ofPeanut Consumption in Infants at Risk for Peanut Allergy,” N ENGL J MED 372:803-813.)因此,在用于产后母乳喂养她的婴儿的产后母亲的营养组合物中包含坚果或坚果提取物可以用于预防婴儿的坚果过敏。坚果(例如,坚果粉)或坚果提取物的含量可以为每份营养组合物5-8盎司。在某些实施方案中,坚果或坚果提取物在营养组合物中以约0.1盎司至约5盎司、约0.5盎司至约5盎司、约1盎司至约5盎司或约3盎司至约5盎司的量存在。
适用于本发明组合物的示例性坚果提取物包括含有花生或树生坚果的抗原蛋白的任何提取物,包括液体或粉末形式的提取物。示例性树生坚果包括腰果、开心果、榛子、核桃、美洲山核桃、巴西坚果、杏仁和松子。
在某些实施方案中,钙包含在所述营养组合物中。钙可以柠檬酸钙、醋酸钙、葡萄糖酸钙、氯化钙、乳酸钙、磷酸钙或硫酸钙等形式添加到所述营养组合物中。钙可以每份营养组合物至多1000 mg的量添加。例如,钙可以每份约500 mg至约1000 mg的量添加。在某些实施方案中,钙以每份营养组合物500 mg的量添加。在其他实施方案中,钙以每份营养组合物1000 mg的量添加。
在某些实施方案中,维生素D可以包含在所述营养组合物中。维生素D可以钙化醇、胆钙化醇、维生素D3和/或1,25-二羟基维生素D的形式添加到营养组合物中。维生素D可以例如作为维生素D油的稳定维生素D粉末而包含。在某些实施方案中,维生素D的含量可以为每份营养组合物约800 IU至约1000 IU。在某些实施方案中,维生素D的含量为每份营养组合物约800 IU。在某些实施方案中,维生素D的含量为每份营养组合物约1000 IU。
一种或多种另外的维生素和/或矿物质还可以以足以供应产后母亲的每日营养需求的量包含在所述营养组合物中。例如,组合物可以任选地包含但不限于以下维生素或其衍生物中的一种或多种:维生素B1(硫胺素、焦磷酸硫胺素、TPP、三磷酸硫胺素、TTP、盐酸硫胺素、单硝酸硫胺素)、维生素B2(核黄素、黄素单核苷酸、FMN、黄素腺嘌呤二核苷酸、FAD、乳黄素、卵黄素)、维生素B3(烟酸、烟碱酸、烟酰胺、烟碱酰胺、烟酰胺腺嘌呤二核苷酸、NAD、烟碱酸单核苷酸、NicMN、吡啶-3-甲酸)、维生素B3-前体色氨酸、维生素B6(吡哆醇、吡哆醛、吡哆胺、盐酸吡哆醇)、泛酸(泛酸盐(pantothenate)、泛醇)、叶酸盐(叶酸(folic acid)、叶酸(folacin)、蝶酰谷氨酸)、维生素B12(钴胺素、甲基钴胺素、脱氧腺苷钴胺素、氰钴胺素、羟基钴胺素、腺苷钴胺素)、生物素、维生素C(抗坏血酸)、维生素A(视黄醇、乙酸视黄酯、棕榈酸视黄酯、具有其他长链脂肪酸的视黄酯、视黄醛、视黄酸、视黄醇酯)、维生素E(α-生育酚、α-生育酚乙酸酯、α-生育酚琥珀酸酯、α-生育酚烟酸酯、α-生育酚)、维生素K(维生素K1、叶绿醌、萘醌、维生素K2、甲基萘醌-7、维生素K3、甲基萘醌-4、甲萘醌、甲基萘醌-8、甲基萘醌-8H、甲基萘醌-9、甲基萘醌-9H、甲基萘醌-10、甲基萘醌-11、甲基萘醌-12、甲基萘醌-13)、胆碱、肌醇、β-胡萝卜素及其任何组合。
在某些实施方案中,组合物可以任选地包含但不限于以下矿物质或其衍生物中的一种或多种:硼、氯化物、铬、氯化铬、吡啶甲酸铬、铜、硫酸铜(copper sulfate)、葡萄糖酸铜、硫酸铜(cupric sulfate)、氟化物、铁、羰基铁、三价铁、富马酸亚铁、正磷酸铁、铁研磨(iron trituration)、多糖铁、碘化物、碘、镁、碳酸镁、氢氧化镁、氧化镁、硬脂酸镁、硫酸镁、锰、钼、磷、钾、磷酸钾、碘化钾、氯化钾、乙酸钾、硒、硫、钠、多库酯钠、氯化钠、硒酸钠、钼酸钠、锌、氧化锌、硫酸锌及其混合物。矿物质化合物的非限制性示例性衍生物包括任何矿物质化合物的盐、碱性盐、酯和螯合物。
矿物质可以以盐(如磷酸钙、甘油磷酸钙、柠檬酸钠、氯化钾、磷酸钾、磷酸镁、硫酸亚铁、硫酸锌、硫酸铜、硫酸锰和***钠)的形式添加到营养组合物中。
在一些实施方案中,本文描述的公开的营养组合物还可以包含有效量的铁。铁可以包含包封的铁形式,例如包封的富马酸亚铁或包封的硫酸亚铁,或较低反应性的铁形式,例如焦磷酸铁或正磷酸铁。
本公开的营养组合物可以任选地包含以下调味剂中的一种或多种,所述调味剂包括但不限于调味提取物、挥发油、可可或巧克力调味料、花生酱调味料、饼干屑、香草或任何市售调味料。可用的调味料的实例包括但不限于纯茴香提取物、仿香蕉提取物、仿樱桃提取物、巧克力提取物、纯柠檬提取物、纯橙提取物、纯薄荷提取物、蜂蜜、仿菠萝提取物、仿朗姆提取物、仿草莓提取物或香草提取物;或挥发油,例如蜂花油、月桂油、香柠檬油、雪松油、樱桃油、肉桂油、丁香油或薄荷油;花生酱、巧克力调味料、香草饼干屑、奶油糖、乳脂糖及其混合物。调味剂的量可以根据使用的调味剂而大大改变。可以如本领域已知的那样选择调味剂的类型和量。
本公开的营养组合物可以任选地包含一种或多种乳化剂,可以添加所述乳化剂以稳定最终产品。合适乳化剂的实例包括但不限于卵磷脂(例如,来自蛋或大豆)、α乳清蛋白和/或甘油单酯和甘油二酯及其混合物。其他乳化剂对于技术人员来说是显而易见的,且一种或多种合适乳化剂的选择将部分地取决于制剂和最终产品。
本公开的营养组合物可以任选地包含一种或多种防腐剂,也可以添加所述防腐剂以延长产品的保质期。合适的防腐剂包括但不限于山梨酸钾、山梨酸钠、苯甲酸钾、苯甲酸钠、EDTA二钠钙及其混合物。
本公开的营养组合物可以任选地包含一种或多种稳定剂。用于实施本公开的营养组合物的合适稳定剂包括但不限于***树胶、印度胶、刺梧桐树胶、黄蓍胶、琼脂、角叉藻胶、瓜尔胶、结冷胶、刺槐豆胶、果胶、低甲氧基果胶、明胶、微晶纤维素、CMC(羧甲基纤维素钠)、甲基纤维素羟丙基甲基纤维素、羟丙基纤维素、DATEM(双乙酰酒石酸甘油单酯和双乙酰酒石酸甘油双酯)、葡聚糖、角叉菜胶及其混合物。
本公开的营养组合物可以提供最小、部分或全部的营养支持。所述组合物可以是营养补充物或膳食替代品。所述组合物可以但不必是营养完全的。在一个实施方案中,本公开的营养组合物是营养完全的并且含有合适类型和量的脂质、碳水化合物、蛋白质、维生素和矿物质。脂质或脂肪的含量可以为每份至多约20 g,通常在每份约5.4 g至约20 g之间变化。蛋白质的含量可以为每份至多约6 g,通常在每份约3 g至约6 g之间变化。碳水化合物的含量可以为每份至多约30 g,通常在每份约11 g至约30 g之间变化。
在某些实施方案中,营养组合物不包含添加的糖。在某些实施方案中,单份营养组合物含有175-300卡路里(kcal)。营养组合物可以使用人工甜味剂(例如甜菊)或水解的乳糖增甜。在某些实施方案中,人造甜味剂包含在水果基饮品中。在其他实施方案中,水解的乳糖包含在乳基饮品中。
一种或多种所公开的营养组合物可以以本领域已知的任何形式提供,例如粉末、凝胶、混悬剂、糊剂、固体、液体、液体浓缩物、可重构的奶粉替代品或即用型产品。本公开的营养组合物包括例如可口服摄取的促进健康的物质,包括例如食品、饮品、片剂、软胶糖、胶囊和粉末。此外,本公开的营养组合物可以标准化为特定的卡路里含量,其可以作为即用型产品提供,或者其可以以浓缩形式提供。
在一个优选的实施方案中,营养组合物以即用型乳基饮品、水果基饮品、坚果乳基饮品或豆乳基饮品提供。在某些实施方案中,营养组合物以酸奶饮品(如酸奶奶昔)提供。在某些实施方案中,水果基饮品包括苹果汁、橙汁、菠萝汁、芒果汁、葡萄汁或其任何组合。在某些实施方案中,坚果乳基饮品包括花生乳、腰果乳、开心果乳、榛子乳、核桃乳、美洲山核桃乳、巴西坚果乳、杏仁乳和松子乳。
在一些实施方案中,营养组合物以粉末形式,粒度在5 μm至1500 μm范围内,更优选在10 μm至300 μm范围内。粉末形式的营养组合物可以以单份小包或小袋提供。
除非另有说明或通过其中进行引用的组合的上下文清楚地暗示相反情况,否则本文所用的方法或工艺步骤的所有组合可以以任何顺序执行。
本公开的方法和组合物,包括其组分,可以包含本文所述的实施方案的基本要素和限制以及本文所述的任何另外或任选的成分、组分或限制或可用于营养组合物中的其他物质,由其组成或基本上由其组成。
制剂实施例
实施例1
在本实施例中,提供了用于所有产后母亲(母乳喂养的那些和非母乳喂养的那些)的乳基补充物,其提供唾液乳糖、DHA、LGG、姜黄、钙和维生素D。所述补充物可以呈粉末、冷藏的保质期延长的液体、软胶糖或布丁的形式。
实施例1:乳基饮品
每份的关键成分量:唾液乳糖(对于每份10克)–(牛源,原料中4-4.2% SAL)–240-300克(考虑到降解和/或加工损失和/或保质期,可以超量添加);唾液乳糖(对于每份10克)–(合成来源,90%纯度)–≤2克(考虑到降解和/或加工损失和/或保质期,可以超量添加);胡芦巴籽粉(对于每份1500毫克)–至多3克;姜黄粉(对于每份50毫克姜黄色素)–≤2.4克;DHA油(对于每份200毫克)–0.5克(考虑到降解和/或加工损失和/或保质期,可以超量添加);维生素D胆钙化醇浓缩液(对于每份1000 IU)–1毫克;柠檬酸钙(对于每份1000毫克)–2.35-4.7克(考虑到降解和/或加工损失和/或保质期,可以超量添加);LGG (每份)–≤1克纯培养物(考虑到降解和/或加工损失和/或保质期,可以超量添加);酸奶/乳;乳清蛋白浓缩物;水解的乳糖和/或人工甜味剂;维生素;矿物质。
实施例2在本实施例中,用于所有产后母亲(母乳喂养的那些和非母乳喂养的那些)的补充物提供唾液乳糖、DHA、LGG培养物、坚果或坚果提取物、姜黄、钙和维生素D。
乳和坚果基产品:粉末、冷藏ESL液或软胶糖或布丁
唾液乳糖(对于每份10克)–(牛源,原料中4-4.2% SAL)–240-300克(考虑到降解和/或加工损失和/或保质期,可以超量添加);唾液乳糖(对于每份10克)–(合成来源,90%纯度)–≤2克(考虑到降解和/或加工损失和/或保质期,可以超量添加);胡芦巴籽粉(对于每份1500毫克)–至多3克;姜黄粉(对于每份50毫克姜黄色素)–2.4克(考虑到降解和/或加工损失和/或保质期,可以超量添加);DHA油(对于每份200毫克)–0.5克(考虑到降解和/或加工损失和/或保质期,可以超量添加);维生素D胆钙化醇浓缩液(对于每份1000 IU)–1毫克(考虑到降解和/或加工损失和/或保质期,可以超量添加);柠檬酸钙(对于每份1000毫克)–2.35-4.7克;坚果粉(每份)–至多28克;LGG (每份)–≤1克纯培养物(考虑到降解和/或加工损失和/或保质期,可以超量添加);酸奶/乳;水解的乳糖;人工甜味剂;维生素;矿物质。
实施例3
在本实施例中,用于母乳喂养产后母亲的补充物提供唾液乳糖、DHA、LGG、胡芦巴、坚果或坚果提取物、姜黄、钙和维生素D。
乳、坚果和水果基产品:粉末、冷藏ESL液或软胶糖或布丁
成分如下:唾液乳糖(对于每份10克)–(牛源,原料中4-4.2% SAL)–240-300克(考虑到降解和/或加工损失和/或保质期,可以超量添加);唾液乳糖(对于每份10克)–(合成来源,90%纯度)–≤1克(考虑到降解和/或加工损失和/或保质期,可以超量添加);胡芦巴籽粉(对于每份1500毫克)–至多3克;姜黄粉(对于每份50毫克姜黄色素)–2.4克;DHA油(对于每份200毫克)–0.5克(考虑到降解和/或加工损失和/或保质期,可以超量添加);维生素D胆钙化醇浓缩液(对于每份1000 IU)–1毫克(考虑到降解和/或加工损失和/或保质期,可以超量添加);柠檬酸钙(对于每份1000毫克)–2.35-4.7克;坚果粉(每份)–至多28克;LGG (每份)–≤1克纯培养物(考虑到降解和/或加工损失和/或保质期,可以超量添加);果泥;酸奶;乳清蛋白浓缩物;水解的乳糖;人工甜味剂;维生素;矿物质。
实施例4
在本实施例中,用于母乳喂养产后母亲的补充物提供唾液乳糖、DHA、LGG、胡芦巴、姜黄、钙和维生素D。
实施例4:坚果基产品或素食:粉末、冷藏ESL液或软胶糖或布丁
成分:唾液乳糖(对于每份10克)–(牛源,原料中4-4.2% SAL)–240-300克(考虑到降解和/或加工损失和/或保质期,可以超量添加);唾液乳糖(对于每份10克)–(合成来源,90%纯度)–≤1克(考虑到降解和/或加工损失和/或保质期,可以超量添加);胡芦巴籽粉(对于每份1500毫克)–至多3克;姜黄粉(对于每份50毫克姜黄色素)–2.4克;DHA油(对于每份200毫克)–0.5克;维生素D胆钙化醇浓缩液(对于每份1000 IU)–1毫克;柠檬酸钙(对于每份1000毫克)–2.35-4.7克;坚果乳-6盎司或坚果粉(每份)–至多28克;LGG (每份)–≤1克纯培养物(考虑到降解和/或加工损失和/或保质期,可以超量添加);果泥;植物蛋白;水解的乳糖;人工甜味剂;维生素;矿物质。
提供配方实例以说明本公开的营养组合物的一些实施方案,但不应解释为对其的任何限制。考虑到本文公开的营养组合物和方法的说明书或实践,对于本领域技术人员,本文中权利要求书的范围内的其他实施方案将是显而易见的。说明书与本文公开的所有实例一起旨在被认为仅是示例性的,本公开的范围和精神由实例后面的权利要求书指示。
本说明书中引用的所有参考文献,包括但不限于所有文章、出版物、专利、专利申请、展示、文本、报告、手稿、手册、书籍、互联网帖子、期刊论文、期刊等,在此通过引用以其整体并入到本说明书中。对本文参考文献的讨论仅旨在概述其作者所作出的断言,且并非承认任何参考文献构成现有技术。申请人保留质疑所引用参考文献的准确性和相关性的权利。
尽管已使用具体的术语、装置和方法描述了本公开的实施方案,但这样的描述仅用于说明性目的。使用的词语是描述性词语而不是限制性词语。应当理解,本领域普通技术人员可以在不脱离所附权利要求中阐述的本公开的精神或范围的情况下进行改变和变化。另外,应该理解的是,不同实施方案的各方面可以整体或部分地互换。因此,所附权利要求的精神和范围不应限于其中所包含的版本的描述。
Claims (20)
1.用于支持产后母亲健康的营养组合物,其包含唾液乳糖、长链多不饱和脂肪酸(LCPUFA)和益生菌。
2.权利要求1所述的营养组合物,其还包含一种或多种选自胡芦巴、姜黄、坚果提取物、钙、维生素D及其混合物的成分。
3.权利要求1或权利要求2所述的营养组合物,其中所述营养组合物还包含胡芦巴、姜黄和坚果提取物。
4.前述权利要求中任一项所述的营养组合物,其中所述唾液乳糖以每份所述营养组合物约7 g至10 g的量存在。
5.前述权利要求中任一项所述的营养组合物,其中所述唾液乳糖包含3'-唾液乳糖、6'-唾液乳糖或3'-唾液乳糖与6'-唾液乳糖的组合。
6.前述权利要求中任一项所述的营养组合物,其中所述LCPUFA以每份所述营养组合物约150 mg至约200 mg的量存在。
7.前述权利要求中任一项所述的营养组合物,其中所述LCPUFA包含二十二碳六烯酸(DHA)。
8.前述权利要求中任一项所述的营养组合物,其中所述益生菌以每份所述营养组合物至多约1.5×1010 cfu的量存在。
9.前述权利要求中任一项所述的营养组合物,其中所述益生菌包含鼠李糖乳杆菌(Lactobacillus rhamnosus) GG (LGG)。
10.权利要求2至9中任一项所述的营养组合物,其中所述胡芦巴以每份所述营养组合物至多约1500 mg的量存在。
11.权利要求2至10中任一项所述的营养组合物,其中所述姜黄以足以提供每份所述营养组合物至多50 mg总姜黄色素(curcuminoid)的量存在。
12.权利要求2至11中任一项所述的营养组合物,其中所述坚果提取物以每份所述营养组合物至多约1.5盎司的量存在。
13.权利要求2至12中任一项所述的营养组合物,其中所述钙以每份所述营养组合物约500 mg至约1000 mg的量存在。
14.权利要求2至13中任一项所述的营养组合物,其中所述维生素D以每份所述营养组合物约800 IU至约1000 IU的量存在。
15.前述权利要求中任一项所述的营养组合物,其中所述营养组合物呈液体或粉末的形式。
16.权利要求15所述的营养组合物,其中所述液体营养组合物选自乳基饮品、果汁基饮品和坚果乳基饮品。
17.权利要求16所述的营养组合物,其中所述乳基饮品为酸奶饮品。
18.权利要求15至17中任一项所述的营养组合物,其中所述液体被包装成6至7盎司份和/或其中所述营养组合物具有60-80 kcal/份。
19.一种支持产后母亲健康的方法,所述方法包括向所述母亲给予权利要求1至18中任一项所述的营养组合物。
20.一种预防产后母亲的产后抑郁和/或焦虑或降低产后母亲的产后抑郁和/或焦虑的严重程度的方法,所述方法包括向所述母亲给予权利要求1至18中任一项所述的营养组合物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1807540.8 | 2018-05-09 | ||
GB1807540.8A GB2573539A (en) | 2018-05-09 | 2018-05-09 | Wellbeing supplement for postpartum maternal nutrition |
PCT/EP2019/061979 WO2019215302A1 (en) | 2018-05-09 | 2019-05-09 | Wellbeing supplement for postpartum maternal nutrition |
Publications (1)
Publication Number | Publication Date |
---|---|
CN112118848A true CN112118848A (zh) | 2020-12-22 |
Family
ID=62598269
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201980031177.9A Pending CN112118848A (zh) | 2018-05-09 | 2019-05-09 | 产后产妇营养的健康补充物 |
Country Status (11)
Country | Link |
---|---|
US (2) | US20210068439A1 (zh) |
EP (1) | EP3790555A1 (zh) |
CN (1) | CN112118848A (zh) |
AU (1) | AU2019267144B2 (zh) |
BR (1) | BR112020021987A2 (zh) |
CA (1) | CA3098535A1 (zh) |
GB (1) | GB2573539A (zh) |
MX (1) | MX2020011637A (zh) |
PH (1) | PH12020551849A1 (zh) |
SG (1) | SG11202010751XA (zh) |
WO (1) | WO2019215302A1 (zh) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20150305385A1 (en) * | 2014-04-25 | 2015-10-29 | Mead Johnson Nutrition Company | Pediatric nutritional composition with human milk oligosaccahrides, prebiotics and probiotics |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5407957A (en) | 1990-02-13 | 1995-04-18 | Martek Corporation | Production of docosahexaenoic acid by dinoflagellates |
DE69231793T2 (de) | 1991-01-24 | 2001-11-08 | Martek Corp., Columbia | Mikrobielle öle und ihre verwendungen |
US20040101495A1 (en) * | 2002-11-27 | 2004-05-27 | Leena Nase | Method for improving dental health |
CA2628225C (en) | 2005-11-04 | 2014-06-17 | Hans Henrik Holst | A concentrate derived from a milk product enriched in naturally occurring sialyllactose and a process for preparation thereof |
SI1991690T1 (sl) | 2006-03-09 | 2014-06-30 | Centre National De La Recherche Scientifique (Cnrs) | Postopek za pridobivanje sializiranih oligosaharidov |
US20070248696A1 (en) * | 2006-04-25 | 2007-10-25 | Mind Sports Nutrition Inc. | Composition and method for enhancing neuromuscular facilitation and cognitive functions |
CA2801776C (en) * | 2010-06-28 | 2020-02-25 | Nestec S.A. | Methods for administering tube feed formulations |
CA2822660C (en) * | 2010-12-31 | 2021-09-07 | Abbott Laboratories | Synbiotic combination of probiotic and human milk oligosaccharides |
WO2012092156A1 (en) * | 2010-12-31 | 2012-07-05 | Abbott Laboratories | Methods for decreasing the incidence of necrotizing enterocolitis in infants, toddlers, or children using human milk oligosaccharides |
MX350436B (es) * | 2011-10-18 | 2017-09-06 | Nestec Sa | Composicion para uso en el aumento de sensibilidad a la insulina y/o la reduccion de resistencia a la insulina. |
US9339453B2 (en) * | 2012-02-24 | 2016-05-17 | Nowsystem, Inc. | Compositions and related methods for oral wellness |
TW201438719A (zh) * | 2012-12-18 | 2014-10-16 | Abbott Lab | 改善壓力症狀之母乳寡糖 |
KR101525230B1 (ko) | 2013-05-31 | 2015-06-01 | 주식회사 진켐 | 시알산 유도체의 제조방법 |
US20160038553A1 (en) * | 2014-08-06 | 2016-02-11 | Fairhaven Health, Llc | Nutritional supplement comprising herbal galactagogue |
WO2016046294A1 (en) * | 2014-09-25 | 2016-03-31 | Nestec S.A. | INFANT FORMULA SYSTEM WITH ADAPTIVE LEVELS OF HUMAN MILK OLIGOSACCHARIDES (HMOs) |
US20160095339A1 (en) * | 2014-10-01 | 2016-04-07 | Mead Johnson Nutrition Company | Nutritional composition for gastrointestinal environment to provide improved microbiome and metabolic profile |
US20170367391A1 (en) * | 2015-11-14 | 2017-12-28 | Wendy Colson | Bars and Shakes utilizing proprietary blend of herbs for enhanced human lactation and breastfeeding. |
US20180103675A1 (en) * | 2016-10-14 | 2018-04-19 | Mead Johnson Nutrition Company | Personalized pediatric nutrition products comprising human milk oligosaccharides |
-
2018
- 2018-05-09 GB GB1807540.8A patent/GB2573539A/en not_active Withdrawn
-
2019
- 2019-05-09 AU AU2019267144A patent/AU2019267144B2/en active Active
- 2019-05-09 EP EP19723396.8A patent/EP3790555A1/en not_active Withdrawn
- 2019-05-09 CA CA3098535A patent/CA3098535A1/en not_active Abandoned
- 2019-05-09 CN CN201980031177.9A patent/CN112118848A/zh active Pending
- 2019-05-09 MX MX2020011637A patent/MX2020011637A/es unknown
- 2019-05-09 SG SG11202010751XA patent/SG11202010751XA/en unknown
- 2019-05-09 BR BR112020021987-8A patent/BR112020021987A2/pt not_active Application Discontinuation
- 2019-05-09 WO PCT/EP2019/061979 patent/WO2019215302A1/en unknown
- 2019-05-09 US US17/053,324 patent/US20210068439A1/en not_active Abandoned
-
2020
- 2020-11-03 PH PH12020551849A patent/PH12020551849A1/en unknown
-
2024
- 2024-02-20 US US18/581,744 patent/US20240188617A1/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20150305385A1 (en) * | 2014-04-25 | 2015-10-29 | Mead Johnson Nutrition Company | Pediatric nutritional composition with human milk oligosaccahrides, prebiotics and probiotics |
Non-Patent Citations (1)
Title |
---|
GEORGE DU TOIT等: "randomized trial of peanut allergy", 《THE NEW ENGLAND JOURNAL OF MEDICINE》, vol. 372, no. 9, pages 2626 - 813 * |
Also Published As
Publication number | Publication date |
---|---|
WO2019215302A1 (en) | 2019-11-14 |
MX2020011637A (es) | 2020-12-07 |
US20210068439A1 (en) | 2021-03-11 |
EP3790555A1 (en) | 2021-03-17 |
AU2019267144A1 (en) | 2020-11-19 |
US20240188617A1 (en) | 2024-06-13 |
PH12020551849A1 (en) | 2021-05-17 |
CA3098535A1 (en) | 2019-11-14 |
SG11202010751XA (en) | 2020-11-27 |
GB2573539A (en) | 2019-11-13 |
GB201807540D0 (en) | 2018-06-20 |
BR112020021987A2 (pt) | 2021-01-26 |
AU2019267144B2 (en) | 2022-09-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
TWI499379B (zh) | 保存內源性轉型生長因子-β(TGF-β)的方法 | |
CN105025734A (zh) | 含有富含脂质的部分的营养组合物及其用途 | |
AU2013372899B2 (en) | Nutritional compositions containing magnesium threonate and uses thereof | |
US9457058B2 (en) | Nutritional composition containing a peptide component with anti-inflammatory properties and uses thereof | |
TWI635803B (zh) | 營養奶精組成物 | |
CN105007761A (zh) | 含有具有脂连蛋白刺激特性的肽组分的营养组合物及其用途 | |
CA2997259A1 (en) | Infant formula tablets | |
AU2013360215B2 (en) | Nutritional composition for promoting satiety | |
AU2014260349B2 (en) | Nutritional composition comprising whey and hydrolyzed casein and uses thereof | |
AU2019267144B2 (en) | Wellbeing supplement for postpartum maternal nutrition | |
WO2012078358A1 (en) | Compositions and methods for nutrient delivery | |
US20140170265A1 (en) | Infant formula cubes |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 40045142 Country of ref document: HK |