CN112111444B - 脐带间充质干细胞重编程为肝脏细胞的方法及所制备的肝脏类器官 - Google Patents
脐带间充质干细胞重编程为肝脏细胞的方法及所制备的肝脏类器官 Download PDFInfo
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Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
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CN202110481017.3A CN113388569B (zh) | 2020-08-28 | 2020-08-28 | 肝脏类器官的制备方法 |
CN202010887971.8A CN112111444B (zh) | 2020-08-28 | 2020-08-28 | 脐带间充质干细胞重编程为肝脏细胞的方法及所制备的肝脏类器官 |
PCT/CN2021/115112 WO2022042700A1 (zh) | 2020-08-28 | 2021-08-27 | 脐带间充质干细胞重编程为肝脏细胞的方法及所制备的肝脏类器官 |
PCT/CN2021/115119 WO2022042703A1 (zh) | 2020-08-28 | 2021-08-27 | 肝脏类器官的制备方法 |
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CN202010887971.8A CN112111444B (zh) | 2020-08-28 | 2020-08-28 | 脐带间充质干细胞重编程为肝脏细胞的方法及所制备的肝脏类器官 |
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CN112111444A CN112111444A (zh) | 2020-12-22 |
CN112111444B true CN112111444B (zh) | 2022-03-04 |
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CN202010887971.8A Active CN112111444B (zh) | 2020-08-28 | 2020-08-28 | 脐带间充质干细胞重编程为肝脏细胞的方法及所制备的肝脏类器官 |
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Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
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CN113388569B (zh) * | 2020-08-28 | 2022-05-17 | 广东乾晖生物科技有限公司 | 肝脏类器官的制备方法 |
CN113604420B (zh) * | 2021-07-07 | 2022-07-08 | 南方医科大学珠江医院 | 体外诱导人胎盘间充质干细胞分化为肝细胞的方法及含五味子乙素的组合物 |
CN113512524B (zh) * | 2021-09-14 | 2022-02-01 | 广东乾晖生物科技有限公司 | 一种三维肝脏类器官复苏液和三维肝脏类器官的复苏方法 |
CN113789296B (zh) * | 2021-09-15 | 2023-07-18 | 淮安市第一人民医院 | 高效诱导人脐带间充质干细胞分化为肝细胞的方法及应用 |
CN113897332A (zh) * | 2021-12-09 | 2022-01-07 | 广东乾晖生物科技有限公司 | 微凝胶类肝载体及其制备方法 |
CN115011550B (zh) * | 2022-07-14 | 2024-04-26 | 广东乾晖生物科技有限公司 | 一种用于悬浮培养条件下诱导肝细胞分化成熟的诱导培养基以及方法 |
CN117045680B (zh) * | 2023-10-12 | 2023-12-08 | 北京国卫生物科技有限公司 | 促进肝脏再生的干细胞制剂及其制备方法 |
Citations (5)
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CN101627112A (zh) * | 2006-06-28 | 2010-01-13 | 堪萨斯大学 | 将来自脐带基质的干细胞分化为肝细胞谱系细胞 |
CN102176881A (zh) * | 2008-10-10 | 2011-09-07 | 海斯特赛尔有限公司 | 来自人脐带的脐带胶质的新生物材料 |
CN104768586A (zh) * | 2012-09-04 | 2015-07-08 | 人类起源公司 | 组织生成的方法 |
CN106361463A (zh) * | 2015-07-23 | 2017-02-01 | 天津幂方科技有限公司 | 一种肝脏组织模拟结构及其成形方法 |
CN109337858A (zh) * | 2018-09-20 | 2019-02-15 | 中国人民解放军第二军医大学 | 用于乙肝病毒感染的原代肝细胞来源的肝前体样细胞模型、制备方法及应用 |
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WO2008140141A1 (en) * | 2007-05-16 | 2008-11-20 | Rnl Bio Co., Ltd. | Pharmaceutical composition for preventing and treating liver fibrosis or hepatic cirrhosis comprising mesenchymal stem cell |
WO2011053690A1 (en) * | 2009-10-30 | 2011-05-05 | The University Of North Carolina At Chapel Hill | Multipotent stem cells from the extrahepatic billary tree and methods of isolating same |
CN103396982A (zh) * | 2013-05-28 | 2013-11-20 | 中山大学附属第三医院 | 利用干细胞自分泌细胞外基质并诱导其成为肝细胞的方法 |
CN103861088B (zh) * | 2014-03-04 | 2016-03-23 | 奥思达干细胞有限公司 | 一种治疗原发性肝癌的干细胞制剂及其制备方法 |
CN110317775B (zh) * | 2018-03-30 | 2022-06-10 | 中国科学院分子细胞科学卓越创新中心 | 用于肝细胞培养及肝脏类器官制备的培养基 |
CN113388569B (zh) * | 2020-08-28 | 2022-05-17 | 广东乾晖生物科技有限公司 | 肝脏类器官的制备方法 |
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- 2020-08-28 CN CN202110481017.3A patent/CN113388569B/zh active Active
- 2020-08-28 CN CN202010887971.8A patent/CN112111444B/zh active Active
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2021
- 2021-08-27 WO PCT/CN2021/115112 patent/WO2022042700A1/zh active Application Filing
- 2021-08-27 WO PCT/CN2021/115119 patent/WO2022042703A1/zh active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101627112A (zh) * | 2006-06-28 | 2010-01-13 | 堪萨斯大学 | 将来自脐带基质的干细胞分化为肝细胞谱系细胞 |
CN102176881A (zh) * | 2008-10-10 | 2011-09-07 | 海斯特赛尔有限公司 | 来自人脐带的脐带胶质的新生物材料 |
CN104768586A (zh) * | 2012-09-04 | 2015-07-08 | 人类起源公司 | 组织生成的方法 |
CN106361463A (zh) * | 2015-07-23 | 2017-02-01 | 天津幂方科技有限公司 | 一种肝脏组织模拟结构及其成形方法 |
CN109337858A (zh) * | 2018-09-20 | 2019-02-15 | 中国人民解放军第二军医大学 | 用于乙肝病毒感染的原代肝细胞来源的肝前体样细胞模型、制备方法及应用 |
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WO2022042703A1 (zh) | 2022-03-03 |
CN113388569A (zh) | 2021-09-14 |
CN113388569B (zh) | 2022-05-17 |
CN112111444A (zh) | 2020-12-22 |
WO2022042700A1 (zh) | 2022-03-03 |
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Inventor after: Yi Xiao Inventor after: Gao Yi Inventor after: Chen Feng Inventor after: Li Yang Inventor after: Wang Yifeng Inventor after: Liu Fan Inventor after: Gao Kunjie Inventor before: Gao Yi Inventor before: Yi Xiao Inventor before: Chen Feng Inventor before: Li Yang Inventor before: Wang Yifeng Inventor before: Liu Fan Inventor before: Gao Kunjie |