CN112076281A - 一种增强免疫功能的树舌组合物及其制备方法 - Google Patents
一种增强免疫功能的树舌组合物及其制备方法 Download PDFInfo
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Abstract
一种增强免疫功能的树舌组合物及其制备方法，它涉及中医药领域，本发明的目的是针对现有技术不足，提供一种精细化、充分利用中药资源的方法，提供一种增强免疫功能的组合物、其制备方法及用途。从而提高树舌、沙棘、大蒜的利用率及经济价值。树舌提取物中的多糖、沙棘提取物中的黄酮、大蒜提取物中的大蒜素，这三类物质协同增效，共奏增强人力免疫力之功。这三种物品，既是食品又是药品，使用安全有效。解决了增强免疫力的化学药品的毒副作用大的问题。本发明应用于药物制备领域。
Description
技术领域
本发明属于中医药领域，具体涉及涉及一种增强免疫功能的树舌组合物及其制备方法。
背景技术
树舌，又名赤色老母菌、扁芝。为多孔菌科真菌平盖灵芝的子实体。广泛种植，分布于全国各地。味微苦，性平。归脾、胃经。具有消炎抗癌之功效。用于咽喉炎，食管癌，鼻咽癌。具有调节免疫功能、抗肿瘤、抑菌、调血压的药理作用。
沙棘，为胡颓子科沙棘属植物沙棘的果实，又名醋柳果，酸刺果。沙棘果是一种小浆果植物，落叶灌木或小乔木。沙棘具有很高的营养价值、生态价值和经济价值。是目前世界上含有天然维生素种类最多的珍贵经济林树种，其维生素C的含量远远高于鲜枣和猕猴桃，被誉为天然维生素的宝库。沙棘还可以治疗烧伤、放射病、心脏病、青光眼等疾病，具有独特的药用价值。
大蒜，为百合科葱属植物的地下鳞茎。大蒜不仅可作调味料，而且可入药，是著名的食药两用植物。大蒜鳞茎中含有丰富的蛋白质、低聚糖和多糖类、另外还有脂肪、矿物质等。大蒜有以下药理作用：具有广谱抗菌灭菌和消炎作用，有很强的抗病毒能力；提高免疫功能，抗肿瘤；保护心血管***：抗高血脂和动脉硬化、抗血小板聚集、增强纤维蛋白溶能活性和扩张血管产生降压作用；活化细胞，促进能量产生，加快新陈代谢，扩张血管，改善血液循环，缓解疲劳等作用；保护肝脏调节血糖水平，降低血粘度、预防血栓。
增强免疫力是指通过一定手段来使自身免疫力加强。免疫力是人体自身的防御机制，是人体识别和消灭外来侵入的任何异物、处理衰老、损伤、死亡、变性的自身细胞以及识别和处理体内突变细胞和病毒感染细胞的能力。现代免疫学认为，提高免疫力是人体识别和排除“异己”的生理反应。人体内执行这一功能的是免疫***，有多种方法可以增强免疫力，多食用有益食品。
发明内容
本发明的目的是针对现有技术不足，提供一种精细化、充分利用中药资源的方法，提供一种增强免疫功能的组合物、其制备方法及用途。从而提高树舌、沙棘、大蒜的利用率及经济价值。树舌提取物中的多糖、沙棘提取物中的黄酮、大蒜提取物中的大蒜素，这三类物质协同增效，共奏增强人力免疫力之功。这三种物品，既是食品又是药品，使用安全有效。解决了增强免疫力的化学药品的毒副作用大的问题。
本发明的一种增强免疫功能的树舌组合物，它按照重量份数是由树舌提取物2～4份、沙棘提取物2～4份和大蒜提取物1～3份组成。
进一步地，所述的树舌提取物是通过以下方式获取的：将树舌子实体在70～80℃下烘干4小时，粉碎，过40目筛；用3～5倍量95％的乙醇在70～75℃条件下提取3次，每次2～3小时，合并滤液，减压蒸馏浓缩至比重1.08～1.12，干燥后得到醇提物；在70～80℃用水作为溶剂提取醇提后的树舌残渣2～3小时，减压过滤分离滤渣和滤液，相同的条件重复三次，合并滤液，减压浓缩至比重1.08～1.12，干燥后得到水提物，将醇提物与水提物混合均匀，得树舌提取物。
进一步地，所述的沙棘提取物是通过以下方式获取：
将沙棘清汁进行灭菌处理，低温浓缩，浓缩至比重1.08～1.12，按照质量份数加入3～5份的白糊精、3～5份可溶性淀粉、3～5份的β-环状糊精和100份沙棘的清汁制成混悬液，进行喷雾干燥，制得沙棘提取物。
进一步地，所述的大蒜提取物是按照以下方式获取：
将大蒜去皮、切片，用10倍量95％的乙醇浸泡12小时，将乙醇蒜液分离出，采用超临界CO2萃取法提取，干燥后得大蒜提取物；其中，萃取压力14～16Mpa，萃取温度34～36℃，CO2流量2L/min，萃取时间4～5小时。
进一步地，所述的增强免疫功能的树舌组合物按照重量份数是由树舌提取物3份、沙棘提取物3份和大蒜提取物2份组成。
进一步地，取树舌提取物2～4份、沙棘提取物2～4份和大蒜提取物1～3份，加水溶解，加入蜂蜜，制成口服液、颗粒剂、片剂、散剂、胶囊剂、丸剂或滴丸。
进一步地，所述的口服液、颗粒剂、片剂、散剂、胶囊剂、丸剂或滴丸加入药物赋形剂。
进一步地，所述的药物赋形剂为崩解剂、矫味剂、防腐剂或着色剂。
本发明包含以下有益效果：
现有增强免疫功能的保健品，以营养补充剂类居多，但该类保健品成分单一，作用局限或者不可服用量大，可引起副反应或中毒现象。另一类是中药材的组合物。但该种保健品服用量较提取物类保健品量大且不如提取物类保健品效果明显。还有一种是单一提取物类的保健品。这种保健品作用局限。本发明的目的是针对现有技术不足，提供一种精细化、充分利用中药资源的方法，提供一种增强免疫功能的组合物、其制备方法及用途。从而提高树舌、沙棘、大蒜的利用率及经济价值。树舌提取物中的多糖能够抗肿瘤、增强机体的免疫机制、抗衰老作用；沙棘提取物中的黄酮具有保护心脑、改善血液循环、促进新陈代谢的作用；大蒜提取物中的大蒜素具有抗菌消炎、镇静的作用。这三类物质从免疫***、抗氧化、改善循环方面协同增效，共奏增强人力免疫力之功。这三种物品，既是食品又是药品，使用安全有效。解决了增强免疫力的化学药品的毒副作用大的问题。
具体实施方式
本领域的普通技术人员可以理解，上述各实施方式是实现本发明的具体实施例，而在实际应用中，可以在形式上和细节上对其作各种改变，而不偏离本发明的精神和范围。
为使本发明实施例的目的、技术方案和优点更加清楚明白，下面将详细叙述清楚说明本发明所揭示内容的精神，任何所属技术领域技术人员在了解本发明内容的实施例后，当可由本发明内容所教示的技术，加以改变及修饰，其并不脱离本发明内容的精神与范围。
本发明的示意性实施例及其说明用于解释本发明，但并不作为对本发明的限定。
实施例一
本实施例的一种增强免疫功能的树舌复合物，它按照重量份数是由树舌提取物3份、沙棘提取物3份和大蒜提取物2份组成。
所述的树舌提取物，是按照如下方法制得：
将树舌子实体在70℃下烘干4小时，粉碎，过40目筛，用3倍量乙醇(浓度95％)在75℃下提取3次，每次2小时，合并滤液，减压蒸馏浓缩至比重1.08～1.12，干燥后得到醇提物；在70℃用水作为溶剂提取醇提后的树舌残渣2小时，减压过滤分离滤渣和滤液，相同的条件重复三次，合并滤液，减压浓缩至比重1.08～1.12，干燥后得到水提物。将醇提物与水提物混合均匀，得树舌提取物。
所述的沙棘提取物，是按照如下方法制得：
将沙棘清汁进行灭菌处理，低温浓缩，浓缩至比重1.08～1.12。
按照质量份数，加入5％份的白糊精、5％份可溶性淀粉和5％份的β-环状糊精制成混悬液，进行喷雾干燥，制得沙棘提取物。
所述的大蒜提取物，是按照如下方法制得：
将大蒜去皮、切片，用10倍量乙醇(浓度95％)浸泡12小时，将乙醇蒜液分离出。采用超临界CO2萃取法提取制得，萃取压力16Mpa,萃取温度36℃，CO2流量2L/min，萃取时间5小时。干燥后得大蒜提取物。
本实施例的组合物加适量水溶解，加入适量蜂蜜，制成口服液。按药剂学方法，还可以将本实施例中具有增强免疫功能的组合物制成颗粒剂、片剂、散剂、胶囊剂、丸剂、滴丸当中的一种。本实施例具有增强免疫功能的组合物的各种剂型中，还可加入常规的药物赋形剂，如崩解剂、矫味剂、防腐剂、着色剂等。
上述实施例中的组合物质量标准制定为：
感官要求：粉末状，无正常视力可见外来异物，无异味。
理化指标应符合下表规定
微生物指标应符合下表的规定
实施例二增强免疫功能实验
取昆明种小鼠75只，雌雄各半，体重18～22g，随机分为A组，B组，C组、D组、E组。引进荷瘤小鼠进行腹水传代，选择7～10d生长良好的瘤株，无菌取腹水，稀释后接种于小鼠右侧腋窝下。接种6天后开始肌注给药。
A组为空白对照组，给药生理盐水。B组给药为上述实施例中制剂50mg/kg/d。C组给药为猪苓多糖50mg/kg/d。D组给药为上述实施例中树舌提取物与沙棘提取物的组合物。E组给药为上述实施例中树舌提取物与大蒜提取物的组合物。连续给药10天，每天一次。于末次给药24h后处死小鼠，剥离肿瘤组织。称重肿瘤重量。实验结果见下表：
从实验结果可见，B组、C组瘤重明显低于A组，说明本发明中的一种增强免疫功能的组合物及猪苓多糖，都有抑制肿瘤生长速度的作用。这两种药物具有增强免疫功能。B组抑瘤率高于C组，说明本发明中的一种增强免疫功能的组合物的增强免疫效果优于临床常用的增强免疫功能药物猪苓多糖。D组、E组抑瘤率低于B组，说明树舌提取物、沙棘提取物、大蒜提取物三个物质的组合效果优于其中两种提取物的组合效果。
实施例三增强免疫功能实验
取昆明种小鼠45只，雌雄各半，体重18～22g，随机分为A组，B组，C组。A组为空白对照组，给药生理盐水。B组给药为上述实施例中制剂50mg/kg/d。C组给药为猪苓多糖50mg/kg/d。对小鼠连续灌胃30d后,进行脏体比、血清溶血素和抗体生成细胞测定、迟发型***反应和NK细胞活性测定、单核—巨噬细胞测定。
结果：(1)给药30天后，小鼠的胸腺指数明显升高，A组为0.20土0.02，B组为0.28土0.01，C组为0.24土0.04。(2)给药30天后，小鼠的抗体积数明显升高，A组为115.7土11.5，B组为172.6土26.1，C组为157.8土21.2。同时使动物的溶血空斑数(x 103个/全脾)明显增加，A组为3.19土0.62，B组为4.69+1.14，C组为3.78+0.87。(3)给药30天后，ND细胞的活性(％)明显增强，A组16.56土3.29，B组27.76土2.51，C组22.49土3.82。(4)给药30天后，小鼠细胞的吞噬率及吞噬指数明显增强，A组吞噬率(％)为10.51士1.62，B组为14.29+2.31，C组为12.44土1.87。A组吞噬指数为0.15土0.02，B组为0.18土0.03，C组为0.15士0.02。从实验结果可见，本发明中的一种增强免疫功能的组合物及猪苓多糖，都有增强免疫力的功能。由此可知，实施例一中的增强免疫功能的组合物的增强免疫效果优于临床常用的增强免疫功能药物猪苓多糖。
Claims (8)
1.一种增强免疫功能的树舌组合物，其特征在于它按照重量份数是由树舌提取物2～4份、沙棘提取物2～4份和大蒜提取物1～3份组成。
2.根据权利要求1所述的一种增强免疫功能的树舌组合物，其特征在于所述的树舌提取物是通过以下方式获取的：将树舌子实体在70～80℃下烘干4小时，粉碎，过40目筛；用3～5倍量95％的乙醇在70～75℃条件下提取3次，每次2～3小时，合并滤液，减压蒸馏浓缩至比重1.08～1.12，干燥后得到醇提物；在70～80℃用水作为溶剂提取醇提后的树舌残渣2～3小时，减压过滤分离滤渣和滤液，相同的条件重复三次，合并滤液，减压浓缩至比重1.08～1.12，干燥后得到水提物，将醇提物与水提物混合均匀，得树舌提取物。
3.根据权利要求1所述的一种增强免疫功能的树舌组合物，其特征在于所述的沙棘提取物是通过以下方式获取：
将沙棘清汁进行灭菌处理，低温浓缩，浓缩至比重1.08～1.12，按照质量份数加入3～5份的白糊精、3～5份可溶性淀粉、3～5份的β-环状糊精和100份沙棘的清汁制成混悬液，进行喷雾干燥，制得沙棘提取物。
4.根据权利要求1所述的一种增强免疫功能的树舌组合物，其特征在于所述的大蒜提取物是按照以下方式获取：
将大蒜去皮、切片，用10倍量95％的乙醇浸泡12小时，将乙醇蒜液分离出，采用超临界CO2萃取法提取，干燥后得大蒜提取物；其中，萃取压力14～16Mpa，萃取温度34～36℃，CO2流量2L/min，萃取时间4～5小时。
5.根据权利要求1所述的一种增强免疫功能的树舌组合物，其特征在于所述的增强免疫功能的树舌组合物按照重量份数是由树舌提取物3份、沙棘提取物3份和大蒜提取物2份组成。
6.制备权利要求1所述的一种增强免疫功能的树舌组合物方法，其特征在于取树舌提取物2～4份、沙棘提取物2～4份和大蒜提取物1～3份，加水溶解，加入蜂蜜，制成口服液、颗粒剂、片剂、散剂、胶囊剂、丸剂或滴丸。
7.根据权利要求6所述的一种增强免疫功能的树舌组合物制备方法，其特征在于所述的口服液、颗粒剂、片剂、散剂、胶囊剂、丸剂或滴丸加入药物赋形剂。
8.根据权利要求7所述的一种增强免疫功能的树舌组合物制备方法，其特征在于所述的药物赋形剂为崩解剂、矫味剂、防腐剂或着色剂。
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Application publication date: 20201215 |