CN112022736A - 一种含生物溶菌酶的氨基酸防脱洗发水及其制备方法 - Google Patents
一种含生物溶菌酶的氨基酸防脱洗发水及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种含生物溶菌酶的氨基酸防脱洗发水，包含以下重量份的组分：氨基酸表面活性剂1‑35份、头皮营养改善剂0.5‑10份、生物溶菌酶0.05‑1.0份和维粒新3‑6份。本发明提供的氨基酸防脱洗发水通过各种组分的合理搭配，达到促进头皮微生态细菌结构合理、平衡，改善头皮头发生长环境的效果；同时，减少了头皮炎症刺激和营养不足带来的干枯、掉发、毛囊收缩坏死、头屑等情况，进而达到了稳固发根，强韧头发、防脱的效果。
Description
技术领域
本发明涉及一种洗发水技术领域，尤其是一种含生物溶菌酶的氨基酸防脱洗发水及其制备方法。
背景技术
洗发水是人们的日常生活必需品，这是因为头皮以及头发上会附着有人体自身分泌的油脂、以及微生物有害菌和有益菌的繁殖、死亡导致的分泌物和代谢物、加上汗垢以及头皮脱落，还有吸附灰尘等物体。因此，如果不及时对头发以及头皮进行清洁，不仅会影响头发的美观，还会带来头皮瘙痒、头屑多、头皮发炎、脱发等问题。传统的氨基酸洗发水除了去污能力和温和度外，没有很好的对头发和头皮进行滋养以及头皮微生态的平衡调理的和防脱的功能，从而头皮以及头发的健康不够理想。
针对头发营养及头皮清洁的问题，研发人员已经研发出许多对头皮头发清洁去屑品。但是忽略了对头皮、微生物生态环境及头发的修复功能，因此，头发脆弱、脱发、易损伤、头屑、头痒成为消费者的主要烦恼。
发明内容
基于此，本发明的目的在于克服上述现有技术的不足之处而提供一种具有控油去屑、防脱发，同时有平衡头部微生态功效的含生物溶菌酶的氨基酸防脱洗发水及其制备方法。
为实现上述目的，本发明所采取的技术方案为：一种含生物溶菌酶的氨基酸防脱洗发水，包含以下重量份的组分：氨基酸表面活性剂1-35份、头皮营养改善剂0.5-10份、生物溶菌酶0.05-1.0份和维粒新3-6份。
氨基酸表面活性剂温和可降解，温和亲肤、无刺激性，敏感肌肤也可以使用。
生物溶菌酶对革兰氏阳性菌、马拉色菌、喜氧性孢子形成菌、枯草杆菌和地衣型芽孢杆菌等都有抗菌作用，而对没有细胞壁的人体细胞不会产生不利影响。可作为一种具有杀菌作用的天然抗感染物质，有抗菌、抗病毒、止血、消肿止痛及加快组织恢复功能等作用，对头皮的微生态平衡有重要的调整作用。
维粒新是彗搏科技研发的一种线粒体修复抗衰因子，标准表述为维粒新
可从细胞层面保护、激活线粒体，提升线粒体自身抗氧化能力。同时，可以增强细胞活力与能量再生。运用在头皮和头发上，可以适当保护头皮细胞，强劲发根，配合氨基酸体系的低刺激，以及营养成分的适当补充，和溶菌酶的微生态平衡，达到炎症减少，增长细胞代谢周期。这些功效的表现结果就是配方出了一款洗后防脱、止屑、低刺激、不头痒的洗发水。
优选地，所述氨基酸防脱洗发水，包含以下重量份的组分：氨基酸表面活性剂10-35份、头皮营养改善剂0.5-1.5份、生物溶菌酶0.1-0.2份和维粒新1-2份。
本发明通过将上述组分合理搭配，在维粒新修复头皮细胞线粒体的同时，配合氨基酸表面活性剂的低刺激性，最后通过生物溶菌酶对头皮的微生态的调整，形成了一个防脱抗菌的功能体系。
优选地，所述氨基酸防脱洗发水，还包含以下重量份的组分：植物防腐剂0.01-0.5份、非氨基酸调理表面活性剂0-10份、顺滑剂0.3-3份、赋形剂0.3-5份、气味调理剂0.1-5.0份和pH调节剂0.03-0.2份。
优选地，所述氨基酸防脱洗发水，还包含以下重量份的组分：植物防腐剂0.1-0.2份、非氨基酸调理表面活性剂3-8份、顺滑剂0.3-3份、赋形剂2-5份、气味调理剂0.1-5.0份和pH调节剂0.03-0.2份。
本发明的顺滑剂采用水溶硅油等替代传统非水溶性硅油硅脂等硅类洗涤冲洗顺滑复合物，水性硅类避免了油性硅类物质的残留和密闭的缺点；本发明所述所述气味调理剂来源于水溶植物香氛纯露。
优选地，所述氨基酸表面活性剂为橄榄谷氨酸钠、椰油酰基谷氨酸钠、月桂酰基肌氨酸钠、椰油酰基丙氨酸钠、月桂酰基甘氨酸钠和月桂酰小麦氨基酸钾中的至少一种；所述头皮营养改善剂为烟酰胺、肌醇、丹皮酚、阳离子泛醇、芦荟提取液、尿囊素和羟乙基脲中的至少一种。
在洗发水中加入烟酰胺、肌醇、丹皮酚、阳离子泛醇、芦荟提取液、尿囊素和羟乙基脲，搭配组合提供头皮修护和头发营养成分。
优选地，所述氨基酸防脱洗发水，如下(a)-(e)中的至少一项：
(a)所述非氨基酸调理表面活性剂为琥珀酸二钠、月桂基羟基磺基甜菜碱、二亚油酰胺丙基PG-二甲基氯化铵磷酸酯钠、椰油酰胺丙基PG-二甲基氯化铵和椰油酰甲基牛磺酸钠中的至少一种；
(b)所述顺滑剂为异壬酸异壬酯、水溶硅油和水溶苯硅油中的至少一种；
(c)所述赋形剂为水溶性聚合物聚乙二醇、PEG-120甲基葡糖二油酸酯和PEG-200甘油硬脂酸酯中的至少一种；
(d)所述植物防腐剂为肉桂树皮提取物、大豆籽提取物、迷迭香提取物、柑橘果皮提取物和小决明籽提取物中的至少一种；
(e)所述pH调节剂为柠檬酸和柠檬酸钠中的至少一种。
此外，本发明还提供了所述氨基酸防脱洗发水的制备方法，包括以下步骤：
(1)将pH调节剂和水依次加入乳化锅，加热搅拌，溶解完全后得到混合液A；
(2)向步骤(1)中得到的混合液A加入氨基酸表面活性剂、非氨基酸调理表面活性剂和赋形剂，加热搅拌，得到透明混合液B；
(3)将步骤(2)中得到的混合液B降温，加入头皮营养改善剂和顺滑剂，搅拌均匀后加入植物防腐剂、生物溶菌酶和维粒新，溶解后得到所述的氨基酸防脱洗发水。
优选地，所述步骤(1)中，加热的温度为75-85℃；所述步骤(2)中，加热的温度为75-85℃。
优选地，所述步骤(3)中，降温至40-50℃。
相对于现有技术，本发明的有益效果为：本发明的氨基酸防脱洗发水通过各种组分的合理搭配，改善了头皮微生态细菌结构，达到了平衡微生物，改善头皮头发生长环境的效果；同时，减少了头皮炎症刺激和营养不足带来的干枯、掉发、毛囊收缩坏死、头屑等情况，达到稳固发根，强韧头发、防脱的效果。
具体实施方式
为更好的说明本发明的目的、技术方案和优点，下面将结合具体实施例对本发明作进一步说明。
本申请设置实施例1-5，具体实施例1-5的组分及重量份选择如表1和表2所示
表1实施例1-5组分及重量份选择
| 实施例1 | 实施例2 | 实施例3 | 实施例4 | 实施例5 | |
| 氨基酸表面活性剂 | 1 | 35 | 10 | 35 | 20 |
| 头皮营养改善剂 | 0.5 | 10 | 0.5 | 1.5 | 1 |
| 生物溶菌酶 | 0.05 | 1 | 0.1 | 0.2 | 0.15 |
| 维粒新 | 3 | 6 | 1 | 2 | 1.5 |
| 植物防腐剂 | 0.01 | 0.5 | 0.1 | 0.2 | 0.15 |
| 非氨基酸调理表面活性剂 | 10 | 3 | 8 | 5 | |
| 顺滑剂 | 0.3 | 3 | 0.3 | 3 | 1.5 |
| 赋形剂 | 0.3 | 5 | 2 | 5 | 3 |
| 气味调理 | 0.1 | 5 | 0.1 | 5 | 3 |
| pH调节剂 | 0.03 | 0.2 | 0.03 | 0.2 | 0.13 |
表2实施例1-5中各组份的具体选择
实施例1-5按照表1和表2所示的重量份称取各组分后，实施例所述氨基酸防脱洗发水的制备方法如下：
(1)将pH调节剂和水依次加入乳化锅，加热搅拌，溶解完全后得到混合液A；
(2)向步骤(1)中得到的混合液A加入氨基酸表面活性剂、非氨基酸调理表面活性剂和赋形剂，加热搅拌，得到透明混合液B；
(3)将步骤(2)中得到的混合液B降温，加入头皮营养改善剂和顺滑剂，搅拌均匀后加入植物防腐剂、生物溶菌酶和维粒新，溶解后得到所述的氨基酸防脱洗发水。
同时，本发明设置对比例1-6，对比例1-6的组分及重量份选择如表3所示，其中，各组分的具体选择与实施例5完全相同。
表3对比例1-6的组分及重量份选择
试验例
试验对象
选取需要防脱及预防脱发的志愿者110人，平均分为11组，分别使用本申请提供的实施例1-5及对比例1-6提供的洗发水，100天后进行产品体验感、防脱效果和生发效果的统计。
试验标准
感官体验和肤感体验打分0-10分，分数越高，体验感越好；防脱效果和生发效果同按照打分制0-10分，分数越高，防脱和生发效果越好，最终结果是按照10人的平均分采集，倘若有无效数据，应去除后算平均分。
试验结果
试验结果如表4所示
表4试验结果
由表4可知，本发明实施例提供的氨基酸防脱洗发水，经志愿者使用后，反馈较好，70％以上的人觉得感官和肤感体验均很好，且实施例5的氨基酸防脱洗发水，95％的人觉得感官和肤感体验均很好。经对比例分析可知，维粒新、氨基酸表面活性剂和生物溶菌酶对志愿者官和肤感体验影响效果不明显，仅三者均没有的情况下，有影响。
但是，对比例1-6的结果表明，维粒新、氨基酸表面活性剂和生物溶菌酶对防脱和生发效果作用显著，在三者均不存在的情况下，即对比例6的氨基酸防脱洗发水无防脱及生发功效。
最后所应当说明的是，以上实施例仅用以说明本发明的技术方案而非对本发明保护范围的限制，尽管参照较佳实施例对本发明作了详细说明，本领域的普通技术人员应当理解，可以对本发明的技术方案进行修改或者等同替换，而不脱离本发明技术方案的实质和范围。
Claims (9)
1.一种含生物溶菌酶的氨基酸防脱洗发水，其特征在于，包含以下重量份的组分：氨基酸表面活性剂1-35份、头皮营养改善剂0.5-10份、生物溶菌酶0.05-1.0份和维粒新3-6份。
2.如权利要求1所述的氨基酸防脱洗发水，其特征在于，包含以下重量份的组分：氨基酸表面活性剂10-35份、头皮营养改善剂0.5-1.5份、生物溶菌酶0.1-0.2份和维粒新1-2份。
3.如权利要求2所述的氨基酸防脱洗发水，其特征在于，还包含以下重量份的组分：植物防腐剂0.01-0.5份、非氨基酸调理表面活性剂0-10份、顺滑剂0.3-3份、赋形剂0.3-5份、气味调理剂0.1-5.0份和pH调节剂0.03-0.2份。
4.如权利要求3所述的氨基酸防脱洗发水，其特征在于，包含以下重量份的组分：植物防腐剂0.1-0.2份、非氨基酸调理表面活性剂3-8份、顺滑剂0.3-3份、赋形剂2-5份、气味调理剂0.1-5.0份和pH调节剂0.03-0.2份。
5.如权利要求1或2所述的氨基酸防脱洗发水，其特征在于，所述氨基酸表面活性剂为橄榄谷氨酸钠、椰油酰基谷氨酸钠、月桂酰基肌氨酸钠、椰油酰基丙氨酸钠、月桂酰基甘氨酸钠和月桂酰小麦氨基酸钾中的至少一种；所述头皮营养改善剂为烟酰胺、肌醇、丹皮酚、阳离子泛醇、芦荟提取液、尿囊素和羟乙基脲中的至少一种。
6.如权利要求3或4所述的氨基酸防脱洗发水，其特征在于，如下(a)-(e)中的至少一项：
(a)所述非氨基酸调理表面活性剂为琥珀酸二钠、月桂基羟基磺基甜菜碱、二亚油酰胺丙基PG-二甲基氯化铵磷酸酯钠、椰油酰胺丙基PG-二甲基氯化铵和椰油酰甲基牛磺酸钠中的至少一种；
(b)所述顺滑剂为异壬酸异壬酯、水溶硅油和水溶苯硅油中的至少一种；
(c)所述赋形剂为水溶性聚合物聚乙二醇、PEG-120甲基葡糖二油酸酯和PEG-200甘油硬脂酸酯中的至少一种；
(d)所述植物防腐剂为肉桂树皮提取物、大豆籽提取物、迷迭香提取物、柑橘果皮提取物和小决明籽提取物中的至少一种；
(e)所述pH调节剂为柠檬酸和柠檬酸钠中的至少一种。
7.一种如权利要求3-6任一项所述的氨基酸防脱洗发水的制备方法，其特征在于，包括以下步骤：
(1)将pH调节剂和水依次加入乳化锅，加热搅拌，溶解完全后得到混合液A；
(2)向步骤(1)中得到的混合液A加入氨基酸表面活性剂、非氨基酸调理表面活性剂和赋形剂，加热搅拌，得到透明混合液B；
(3)将步骤(2)中得到的混合液B降温，加入头皮营养改善剂和顺滑剂，搅拌均匀后加入植物防腐剂、生物溶菌酶和维粒新，溶解后得到所述的氨基酸防脱洗发水。
8.如权利要求7所述的氨基酸防脱洗发水的制备方法，其特征在于，所述步骤(1)中，加热的温度为75-85℃；所述步骤(2)中，加热的温度为75-85℃。
9.如权利要求7所述的氨基酸防脱洗发水的制备方法，其特征在于，所述步骤(3)中，降温至40-50℃。
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113244159A (zh) * | 2021-05-26 | 2021-08-13 | 广州欧正化妆品技术研究院有限公司 | 一种保湿修复面膜液及其制备方法 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104738033A (zh) * | 2015-02-02 | 2015-07-01 | 广东工业大学 | 一种植物来源的防腐剂组方 |
| CN104800095A (zh) * | 2015-04-22 | 2015-07-29 | 江苏雪豹日化有限公司 | 一种生物溶菌酶复合制剂及其制备方法 |
| CN106398896A (zh) * | 2016-09-07 | 2017-02-15 | 马鞍山纽泽科技服务有限公司 | 一种高效洗涤液及其制备方法 |
| CN110314126A (zh) * | 2019-08-20 | 2019-10-11 | 李梓明 | 一种氨基酸固发洗发水 |
-
2020
- 2020-09-29 CN CN202011047481.3A patent/CN112022736A/zh active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104738033A (zh) * | 2015-02-02 | 2015-07-01 | 广东工业大学 | 一种植物来源的防腐剂组方 |
| CN104800095A (zh) * | 2015-04-22 | 2015-07-29 | 江苏雪豹日化有限公司 | 一种生物溶菌酶复合制剂及其制备方法 |
| CN106398896A (zh) * | 2016-09-07 | 2017-02-15 | 马鞍山纽泽科技服务有限公司 | 一种高效洗涤液及其制备方法 |
| CN110314126A (zh) * | 2019-08-20 | 2019-10-11 | 李梓明 | 一种氨基酸固发洗发水 |
Non-Patent Citations (1)
| Title |
|---|
| 不详: "Vitalitin? Platform 维粒新? 研发平台", 《HOOGBIO》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113244159A (zh) * | 2021-05-26 | 2021-08-13 | 广州欧正化妆品技术研究院有限公司 | 一种保湿修复面膜液及其制备方法 |
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