CN111974226A - Preparation method of disposable polyether sulfone liquid medicine film - Google Patents
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- CN111974226A CN111974226A CN201910437691.4A CN201910437691A CN111974226A CN 111974226 A CN111974226 A CN 111974226A CN 201910437691 A CN201910437691 A CN 201910437691A CN 111974226 A CN111974226 A CN 111974226A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
- B01D71/06—Organic material
- B01D71/66—Polymers having sulfur in the main chain, with or without nitrogen, oxygen or carbon only
- B01D71/68—Polysulfones; Polyethersulfones
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/147—Microfiltration
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
- B01D67/0002—Organic membrane manufacture
- B01D67/0009—Organic membrane manufacture by phase separation, sol-gel transition, evaporation or solvent quenching
- B01D67/0011—Casting solutions therefor
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
- B01D67/0002—Organic membrane manufacture
- B01D67/0009—Organic membrane manufacture by phase separation, sol-gel transition, evaporation or solvent quenching
- B01D67/0013—Casting processes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
- B01D69/10—Supported membranes; Membrane supports
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2323/00—Details relating to membrane preparation
- B01D2323/02—Hydrophilization
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2323/00—Details relating to membrane preparation
- B01D2323/38—Graft polymerization
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2325/00—Details relating to properties of membranes
- B01D2325/14—Membrane materials having negatively charged functional groups
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2325/00—Details relating to properties of membranes
- B01D2325/36—Hydrophilic membranes
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- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Manufacturing & Machinery (AREA)
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Abstract
The invention discloses a preparation method of a disposable polyether sulfone liquid medicine film, and relates to the technical field of biomedical high polymer materials. The method comprises the following steps: step one, mixing and dissolving polyether sulfone with an organic solvent at 40-80 ℃, adding a pore-forming agent, fully stirring and dissolving, filtering insoluble substances, and defoaming in vacuum to obtain a membrane casting solution, wherein the weight parts of polyether sulfone in the membrane casting solution are 15-20, the weight parts of organic solvent are 45-60, and the weight parts of pore-forming agent are 1-10; and step two, casting the casting solution on a support body, and scraping the membrane by using a scraper to obtain a primary membrane. The invention can better graft the hydrophilic bond to the base membrane of the polyethersulfone microfiltration membrane, greatly improves the hydrophilicity of the polyethersulfone membrane, improves the flux of liquid, improves the anti-pollution capability of the filter membrane due to the existence of electric charge, prolongs the service life of the filter membrane, reduces the use cost and has better economic benefit.
Description
Technical Field
The invention belongs to the technical field of biomedical high polymer materials, and particularly relates to a preparation method of a disposable polyether sulfone liquid medicine membrane.
Background
Infusion therapy can supplement nutrients, moisture, electrolytes and the like necessary for human bodies, and has very important effect in clinical treatment. However, the common infusion apparatus can only filter out particles with the diameter of more than 20 microns in the liquid medicine, and has no interception effect on the particles with the diameter of 0.2 to 10 microns. The insoluble particles in the medicine have great harm to human body, may cause angioxun injury, and is easy to produce thrombus, fat embolism, bubble embolism and the like, even form thrombophlebitis, block microcirculation and cause necrosis or injury of human tissues or organs in different degrees. Therefore, research into filtration membranes in medical fluid filters, particularly in drug filters, has become one of the hot spots.
The microfiltration membrane applied to medical clinical infusion terminal filtration, which is produced on the market at present, mainly comprises melt-blown polypropylene non-woven fabrics, polyether sulfone microfiltration membranes produced by a phase inversion method, a nuclear pore membrane, a nylon membrane and the like, wherein the above filtration membranes have some defects, the melt-blown polypropylene non-woven fabrics are long in fiber, easy to fall off, hydrophobic in products, hydrophilic modification in later period is needed, hydrophilic groups are easy to run off, the liquid flow is not qualified, the polyether sulfone microfiltration membrane is also modified to achieve a hydrophilic effect, the durability is poor, the thickness of the nuclear pore membrane is between 0.02mm and 0.03mm, the firmness is poor, the assembly is not easy, the nylon membrane is acid-resistant and alkali-resistant, and the pore diameter can be changed in the presence of alkaline liquid.
Disclosure of Invention
The invention aims to provide a preparation method of a disposable polyether sulfone liquid medicine membrane, which has high aperture ratio, high flow and good filtering effect, is mainly used for filtering and retaining particles at a clinical transfusion terminal and is beneficial to the body health of a patient.
The invention is realized by the following technical scheme:
the invention relates to a preparation method of a disposable polyether sulfone liquid medicine film, which comprises the following steps:
step one, mixing and dissolving polyether sulfone with an organic solvent at 40-80 ℃, adding a pore-forming agent, fully stirring and dissolving, filtering insoluble substances, and defoaming in vacuum to obtain a membrane casting solution, wherein the weight parts of polyether sulfone in the membrane casting solution are 15-20, the weight parts of organic solvent are 45-60, and the weight parts of pore-forming agent are 1-10;
step two, casting the casting solution on a support body, and scraping the membrane by using a scraper to obtain a primary membrane;
step three, staying the primary membrane in the air for 10-150s to volatilize the solvent to form pores, then putting the pores into purified water at the temperature of 18-30 ℃ for cleaning, and then drying the pores at the temperature of 70-100 ℃ to obtain a base membrane of the microfiltration membrane;
step four, immersing the base membrane into a sodium polystyrene sulfonate (PSS) solution, and adsorbing the base membrane on the surface of the base membrane to form a base membrane immersed sodium polystyrene sulfonate (PSS) primary layer with negative electricity through the hydrophobic effect between the hydrophobic main chain of the molecules of the sodium polystyrene sulfonate (PSS) immersed in the base membrane and the surface of the base membrane; then, washing and soaking by using pure water to form a microporous filter membrane with negative charges on the surface;
Immersing the microporous filter membrane with negative charges into a poly dimethyl diallyl ammonium chloride (PDADMAC) polycation solution, and adsorbing the surface of the sodium polystyrene sulfonate (PSS) layer to form a positively charged polycation layer through the interaction between the negatively charged sodium polystyrene sulfonate (PSS) layer and the positively charged polycation; then using pure water to clean and soak the membrane to form a microporous filter membrane with positive charges on the surface, namely the disposable polyether sulfone liquid medicine membrane.
Further, the polyether sulfone is US Suwei PES3000p or Japanese Sumitomo PES5900p, the molecular weight is 2 x 104-5 x 105, the organic solvent is dimethyl acetamide, dimethyl formamide or N-methyl-2-pyrrolidone (NMP), and the pore-forming agent is acetone, absolute ethyl alcohol, polyvinylpyrrolidone (PVP), polyethylene glycol (PEG)200 and polyethylene glycol 400.
Further, the preparation method of the sodium polystyrene sulfonate (PSS) solution in the fourth step comprises the following steps: firstly, deionized water is used for preparing a sodium polystyrene sulfonate (PSS) aqueous solution with the concentration of 0.05-1%, then NaCl is added into the sodium polystyrene sulfonate (PSS) aqueous solution to adjust the concentration of the solution to 5-10%, and then hydrochloric acid is used for adjusting the pH value to 2-4.
Further, the preparation method of the poly dimethyl diallyl ammonium chloride (PDADMAC) solution in the step four comprises the following steps: firstly, deionized water is used for preparing a 0.05-1% polydimethyldiallylammonium chloride (PDADMAC) aqueous solution, then NaCl is added into the polydimethyldiallylammonium chloride (PDADMAC) aqueous solution to adjust the concentration of the solution to 5-10%, and then hydrochloric acid is used for adjusting the pH value to 3-5.
Further, the gap height of the scraper in the second step is 0.12-0.40mm, the film scraping temperature is 18-35 ℃, and the relative humidity is 50-90%.
Further, the thickness of the microfiltration basement membrane obtained in the third step is 0.1mm-0.12mm, and the pore diameter is 0.2 μm-10 μm.
The final charged polyether sulfone liquid medicine film can be adjusted by selecting the base films with different apertures; the surface charge density, the aperture of a charge layer and the pore structure of the charged polyethersulfone liquid medicine membrane can be adjusted by adjusting the concentration of the polyelectrolyte solution, the concentration of a salt additive and the pH value; the microporous filter membrane with positive or negative charges on the surface can be formed through primary adsorption or secondary adsorption.
The invention has the following beneficial effects:
the invention can better graft the hydrophilic bond to the base membrane of the polyethersulfone microfiltration membrane, greatly improves the hydrophilicity of the polyethersulfone membrane, improves the flux of liquid, improves the anti-pollution capability of the filter membrane due to the existence of electric charge, prolongs the service life of the filter membrane, reduces the use cost and has better economic benefit.
Of course, it is not necessary for any product in which the invention is practiced to achieve all of the above-described advantages at the same time.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example one
The preparation method of the disposable polyethersulfone liquid membrane provided by the embodiment comprises the following steps:
step one, mixing and dissolving polyether sulfone with an organic solvent at 40-80 ℃, stirring for 6-10h, adding a pore-forming agent, continuing stirring for 10-12h to fully dissolve, filtering insoluble substances and defoaming in vacuum for 12-24h to obtain a casting solution, wherein the polyether sulfone in the casting solution is Japanese Sumitomo PES5900p, the molecular weight is 3 x 105, the weight is 18g, the weight of the organic solvent is dimethylformamide, the weight is 55g, and the pore-forming agent is absolute ethyl alcohol, and the weight part is 5 g;
step two, casting the casting film liquid on a support body, and scraping the film by using a scraper, wherein the gap height of the scraper is 0.25mm, the film scraping temperature is 30 ℃, and the relative humidity is 80%, so as to obtain a primary film;
step three, the primary membrane stays in the air for 10 to 150 seconds to volatilize the solvent to form pores, then is put into purified water with the temperature of 18 to 30 ℃ to be cleaned for 5 to 8 minutes, and then is dried at the temperature of 70 to 100 ℃ to obtain a base membrane of the microfiltration membrane, wherein the thickness of the base membrane of the microfiltration membrane is 0.11mm, and the pore diameter is 4 mu m;
step four, preparing a 0.05-1% sodium polystyrene sulfonate (PSS) aqueous solution by using deionized water, adding NaCl into the sodium polystyrene sulfonate (PSS) aqueous solution to adjust the concentration of the solution to 5%, then adjusting the pH value to 3 by using hydrochloric acid, immersing the base membrane into the sodium polystyrene sulfonate (PSS) solution, and forming a base membrane with negative electricity by adsorption on the surface of the base membrane, wherein the base membrane is immersed into a hydrophobic interaction between a hydrophobic main chain of a sodium polystyrene sulfonate (PSS) molecule and the surface of the base membrane, and is immersed into a primary layer of the sodium polystyrene sulfonate (PSS); then, washing and soaking by using pure water to form a microporous filter membrane with negative charges on the surface;
Preparing a 0.05-1% polydimethyldiallyl ammonium chloride (PDADMAC) aqueous solution by using deionized water, adding NaCl into the polydimethyldiallyl ammonium chloride (PDADMAC) aqueous solution to adjust the concentration of the solution to 5%, adjusting the pH value to 4 by using hydrochloric acid, immersing a microporous filter membrane with negative charges into a polydimethyldiallyl ammonium chloride (PDADMAC) polycation solution, and adsorbing the surface of a Polystyrene Sodium Sulfonate (PSS) layer with positive charges to form a polycation layer with positive charges by the interaction between the Polystyrene Sodium Sulfonate (PSS) layer with negative charges and the polycation with positive charges; then using pure water to clean and soak the membrane to form a microporous filter membrane with positive charges on the surface, namely the disposable polyether sulfone liquid medicine membrane.
Example two
The preparation method of the disposable polyethersulfone liquid membrane provided by the embodiment comprises the following steps:
step one, mixing and dissolving polyether sulfone with an organic solvent at 40-80 ℃, stirring for 6-10h, adding a pore-forming agent, continuing stirring for 10-12h to fully dissolve, filtering insoluble substances, and defoaming in vacuum for 12-24h to obtain a casting solution, wherein the polyether sulfone in the casting solution is American Suwei PES3000p, the molecular weight is 2 x 104, the weight is 16g, the organic solvent is dimethylacetamide, the weight is 50g, and the pore-forming agent is acetone, and the weight is 2 g;
Step two, casting the casting film liquid on a support body, and scraping the film by using a scraper, wherein the gap height of the scraper is 0.12mm, the film scraping temperature is 20 ℃, and the relative humidity is 70%, so as to obtain a primary film;
step three, the primary membrane stays in the air for 10 to 150 seconds to volatilize the solvent to form pores, then is put into purified water with the temperature of 18 to 30 ℃ to be cleaned for 5 to 8 minutes, and then is dried at the temperature of 70 to 100 ℃ to obtain a microfiltration membrane base membrane, wherein the thickness of the microfiltration membrane base membrane is 0.1, and the pore diameter is 1 mu m;
step four, preparing a 0.05-1% sodium polystyrene sulfonate (PSS) aqueous solution by using deionized water, adding NaCl into the sodium polystyrene sulfonate (PSS) aqueous solution to adjust the concentration of the solution to 8%, then adjusting the pH value to 2 by using hydrochloric acid, immersing the base membrane into the sodium polystyrene sulfonate (PSS) solution, and forming a base membrane with negative electricity by adsorption on the surface of the base membrane, wherein the base membrane is immersed into a hydrophobic interaction between a hydrophobic main chain of a sodium polystyrene sulfonate (PSS) molecule and the surface of the base membrane, and is immersed into a primary layer of the sodium polystyrene sulfonate (PSS); then, washing and soaking by using pure water to form a microporous filter membrane with negative charges on the surface;
preparing a 0.05-1% polydimethyldiallyl ammonium chloride (PDADMAC) aqueous solution by using deionized water, adding NaCl into the polydimethyldiallyl ammonium chloride (PDADMAC) aqueous solution to adjust the concentration of the solution to 8%, adjusting the pH value to 3 by using hydrochloric acid, immersing a microporous filter membrane with negative charges into a polydimethyldiallyl ammonium chloride (PDADMAC) polycation solution, and adsorbing the surface of a Polystyrene Sodium Sulfonate (PSS) layer with positive charges to form a polycation layer with positive charges by the interaction between the Polystyrene Sodium Sulfonate (PSS) layer with negative charges and the polycation with positive charges; then using pure water to clean and soak the membrane to form a microporous filter membrane with positive charges on the surface, namely the disposable polyether sulfone liquid medicine membrane.
EXAMPLE III
The preparation method of the disposable polyethersulfone liquid membrane provided by the embodiment comprises the following steps:
step one, mixing and dissolving polyether sulfone with an organic solvent at 40-80 ℃, stirring for 6-10h, adding a pore-forming agent, continuing stirring for 10-12h to fully dissolve, filtering insoluble substances and defoaming in vacuum for 12-24h to obtain a membrane casting solution, wherein the polyether sulfone in the membrane casting solution is Japanese Sumitomo PES5900p, the molecular weight is 5 multiplied by 105, the weight is 20g, the organic solvent is N-methyl-2-pyrrolidone (NMP), the weight is 60g, and the pore-forming agent is polyvinylpyrrolidone (PVP), and the weight is 10 g;
step two, casting the casting film liquid on a support body, and scraping the film by using a scraper, wherein the gap height of the scraper is 0.40mm, the film scraping temperature is 35 ℃, and the relative humidity is 90%, so as to obtain a primary film;
step three, the primary membrane stays in the air for 10 to 150 seconds to volatilize the solvent to form pores, then is put into purified water with the temperature of 18 to 30 ℃ to be cleaned for 5 to 8 minutes, and then is dried at the temperature of 70 to 100 ℃ to obtain a base membrane of the microfiltration membrane, wherein the thickness of the base membrane of the microfiltration membrane is 0.12mm, and the pore diameter is 10 mu m;
step four, preparing a 0.05-1% sodium polystyrene sulfonate (PSS) aqueous solution by using deionized water, adding NaCl into the sodium polystyrene sulfonate (PSS) aqueous solution to adjust the concentration of the solution to 10%, then adjusting the pH value to 4 by using hydrochloric acid, immersing the base membrane into the sodium polystyrene sulfonate (PSS) solution, and forming a base membrane with negative electricity by adsorption on the surface of the base membrane, wherein the base membrane is immersed into a hydrophobic interaction between a hydrophobic main chain of a sodium polystyrene sulfonate (PSS) molecule and the surface of the base membrane, and is immersed into a primary layer of the sodium polystyrene sulfonate (PSS); then, washing and soaking by using pure water to form a microporous filter membrane with negative charges on the surface;
Preparing a 0.05-1% polydimethyldiallyl ammonium chloride (PDADMAC) aqueous solution by using deionized water, adding NaCl into the polydimethyldiallyl ammonium chloride (PDADMAC) aqueous solution to adjust the concentration of the solution to 10%, then adjusting the pH value to 5 by using hydrochloric acid, immersing a microporous filter membrane with negative charges into a polydimethyldiallyl ammonium chloride (PDADMAC) polycation solution, and adsorbing the surface of a Polystyrene Sodium Sulfonate (PSS) layer with positive charges to form a polycation layer with positive charges by virtue of interaction between the Polystyrene Sodium Sulfonate (PSS) layer with negative charges and the polycation with positive charges; then using pure water to clean and soak the membrane to form a microporous filter membrane with positive charges on the surface, namely the disposable polyether sulfone liquid medicine membrane.
The invention is an effective method for improving the surface property of the membrane, can better graft hydrophilic bonds to a base membrane of a polyether sulfone microfiltration membrane, greatly improves the hydrophilicity of the polyether sulfone membrane, improves the flux of liquid, improves the pollution resistance of the filter membrane due to the existence of electric charges, prolongs the service life of the filter membrane, reduces the use cost and brings economic benefits to enterprises.
In the description herein, references to the description of "one embodiment," "an example," "a specific example" or the like are intended to mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
The preferred embodiments of the invention disclosed above are intended to be illustrative only. The preferred embodiments are not intended to be exhaustive or to limit the invention to the precise embodiments disclosed. Obviously, many modifications and variations are possible in light of the above teaching. The embodiments were chosen and described in order to best explain the principles of the invention and the practical application, to thereby enable others skilled in the art to best utilize the invention. The invention is limited only by the claims and their full scope and equivalents.
Claims (6)
1. A preparation method of a disposable polyether sulfone liquid medicine film is characterized by comprising the following steps: the method comprises the following steps:
step one, mixing and dissolving polyether sulfone with an organic solvent at 40-80 ℃, adding a pore-forming agent, fully stirring and dissolving, filtering insoluble substances, and defoaming in vacuum to obtain a membrane casting solution, wherein the weight parts of polyether sulfone in the membrane casting solution are 15-20, the weight parts of organic solvent are 45-60, and the weight parts of pore-forming agent are 1-10;
step two, casting the casting solution on a support body, and scraping the membrane by using a scraper to obtain a primary membrane;
step three, staying the primary membrane in the air for 10-150s to volatilize the solvent to form pores, then putting the pores into purified water at the temperature of 18-30 ℃ for cleaning, and then drying the pores at the temperature of 70-100 ℃ to obtain a base membrane of the microfiltration membrane;
Step four, immersing the base membrane into a sodium polystyrene sulfonate (PSS) solution, and adsorbing the base membrane on the surface of the base membrane to form a base membrane immersed sodium polystyrene sulfonate (PSS) primary layer with negative electricity through the hydrophobic effect between the hydrophobic main chain of the molecules of the sodium polystyrene sulfonate (PSS) immersed in the base membrane and the surface of the base membrane; then, washing and soaking by using pure water to form a microporous filter membrane with negative charges on the surface;
immersing the microporous filter membrane with negative charges into a poly dimethyl diallyl ammonium chloride (PDADMAC) polycation solution, and adsorbing the surface of the sodium polystyrene sulfonate (PSS) layer to form a positively charged polycation layer through the interaction between the negatively charged sodium polystyrene sulfonate (PSS) layer and the positively charged polycation; then using pure water to clean and soak the membrane to form a microporous filter membrane with positive charges on the surface, namely the disposable polyether sulfone liquid medicine membrane.
2. The method for preparing a disposable polyethersulfone liquid film according to claim 1, wherein said polyethersulfone is us suwei PES3000p or japanese sumitomo PES5900p, molecular weight is 2 x 104-5 x 105, said organic solvent is dimethylacetamide, dimethylformamide or N-methyl-2-pyrrolidone (NMP), and said pore-forming agent is acetone, absolute ethanol, polyvinylpyrrolidone (PVP), polyethylene glycol (PEG)200, polyethylene glycol 400.
3. The method for preparing the disposable polyethersulfone liquid medicine membrane according to claim 1, wherein the method for preparing the sodium polystyrene sulfonate (PSS) solution in the fourth step comprises the following steps: firstly, deionized water is used for preparing a sodium polystyrene sulfonate (PSS) aqueous solution with the concentration of 0.05-1%, then NaCl is added into the sodium polystyrene sulfonate (PSS) aqueous solution to adjust the concentration of the solution to 5-10%, and then hydrochloric acid is used for adjusting the pH value to 2-4.
4. The method for preparing the disposable polyethersulfone pharmaceutical film according to claim 1, wherein the method for preparing the poly dimethyl diallyl ammonium chloride (PDADMAC) solution in the step four comprises the following steps: firstly, deionized water is used for preparing a 0.05-1% polydimethyldiallylammonium chloride (PDADMAC) aqueous solution, then NaCl is added into the polydimethyldiallylammonium chloride (PDADMAC) aqueous solution to adjust the concentration of the solution to 5-10%, and then hydrochloric acid is used for adjusting the pH value to 3-5.
5. The method for preparing the disposable polyether sulfone drug liquid film according to claim 1, wherein the clearance height of the scraper in the second step is 0.12-0.40mm, the scraping temperature is 18-35 ℃, and the relative humidity is 50-90%.
6. The method for preparing the disposable polyethersulfone liquid medicine film according to claim 1, wherein the thickness of the microfiltration membrane basement membrane obtained in the third step is 0.1-0.12 mm, and the pore diameter is 0.2-10 μm.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113230746A (en) * | 2021-06-07 | 2021-08-10 | 温州大学激光与光电智能制造研究院 | Preparation method of filtering membrane |
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| KR20140015173A (en) * | 2012-07-26 | 2014-02-06 | 삼성전자주식회사 | Conductive layered structure, electrode and supercapacitor comprising the conductive layered structure, and method for preparing the conductive layered structure |
| CN106310983A (en) * | 2015-06-23 | 2017-01-11 | 上海振浦医疗设备有限公司 | Disposable polyethersulfone air microfiltration membrane and preparation method thereof |
| CN106310422A (en) * | 2015-06-23 | 2017-01-11 | 上海振浦医疗设备有限公司 | Disposable precise filtering infusion apparatus for filleting bacterial endotoxin |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102580550A (en) * | 2012-03-05 | 2012-07-18 | 中国海洋大学 | Method for producing polyelectrolyte self-assembly composite nanofiltration membrane |
| KR20140015173A (en) * | 2012-07-26 | 2014-02-06 | 삼성전자주식회사 | Conductive layered structure, electrode and supercapacitor comprising the conductive layered structure, and method for preparing the conductive layered structure |
| CN106310983A (en) * | 2015-06-23 | 2017-01-11 | 上海振浦医疗设备有限公司 | Disposable polyethersulfone air microfiltration membrane and preparation method thereof |
| CN106310422A (en) * | 2015-06-23 | 2017-01-11 | 上海振浦医疗设备有限公司 | Disposable precise filtering infusion apparatus for filleting bacterial endotoxin |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113230746A (en) * | 2021-06-07 | 2021-08-10 | 温州大学激光与光电智能制造研究院 | Preparation method of filtering membrane |
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Application publication date: 20201124 |