CN111973494A - Long-acting moisturizing type moisturizing cream and preparation method thereof - Google Patents

Long-acting moisturizing type moisturizing cream and preparation method thereof Download PDF

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CN111973494A
CN111973494A CN202011004202.5A CN202011004202A CN111973494A CN 111973494 A CN111973494 A CN 111973494A CN 202011004202 A CN202011004202 A CN 202011004202A CN 111973494 A CN111973494 A CN 111973494A
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cream
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CN111973494B (en
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刘翠芳
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Guangzhou Her Biotechnology Co ltd
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Nanjing Feitian Yimiao Technology Service Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36Carboxylic acids; Salts or anhydrides thereof
    • A61K8/362Polycarboxylic acids
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K8/375Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/732Starch; Amylose; Amylopectin; Derivatives thereof
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    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/736Chitin; Chitosan; Derivatives thereof
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    • A61K8/84Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89Polysiloxanes
    • A61K8/891Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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    • A61K2800/81Preparation or application process involves irradiation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/84Products or compounds obtained by lyophilisation, freeze-drying

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Abstract

The invention provides a long-acting moisturizing type moisturizing cream and a preparation method thereof, wherein the cream comprises the following components in parts by weight: oil phase: 45-50 parts of chinaroot greenbrier seed oil; 15-20 parts of light liquid paraffin; 3-5 parts of polydimethylsiloxane; 1-2 parts of cetearyl alcohol; 15-20 parts of modified microcapsule particles; water phase: 55-60 parts of deionized water; 15-20 parts of glycerol; 6-8 parts of sodium hyaluronate; 6-8 parts of chitosan; the modified microcapsule is prepared by taking maltodextrin as a wall material and monoglyceride and algal polysaccharide as core materials through spray drying. The prepared microcapsule material with the slow release structure can effectively coat and stay on the surface layer of skin, thereby prolonging the moisturizing performance and the moisturizing duration.

Description

Long-acting moisturizing type moisturizing cream and preparation method thereof
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to a long-acting moisturizing type moisturizing cream and a preparation method thereof.
Background
The human skin is like the human barrier, is tough, soft and elastic, protects tissues and organs in the body from external mechanical, physical, chemical or biological invasion or stimulation, has natural moisture retention performance, and plays an irreplaceable role in keeping human moisture. The skin is divided into three parts, namely epidermis, dermis and subcutaneous tissue, and each layer has different physiological effects on the moisturizing performance of the skin. The moisturizing is to prevent the loss of moisture in the skin and to absorb moisture in the external environment, thereby achieving the purpose of keeping the skin to contain a certain amount of moisture. The main source of skin stratum corneum moisture is sweat secreted by sweat glands. The oily film on the skin surface can prevent the evaporation of water, thereby maintaining the water contained in the stratum corneum of the skin.
Conventional skin moisturizing regimens typically utilize the exogenously supplied source of moisturizing agents to replenish the water lost to the stratum corneum. The moisturizer mainly comprises glycerin, sodium pyrrolidone carboxylate, hydrated gel, hyaluronic acid and derivatives thereof and the like, and can rapidly improve the water replenishing and locking functions of the stratum corneum of the outermost layer of the skin, so that the moisturizer achieves the effect of rapid moisture preservation. However, such materials do achieve long-lasting moisturization. It has a moisturizing effect for a short time only after application, so it is necessary to improve it effectively.
Disclosure of Invention
The present invention is directed to solving at least one of the problems of the prior art.
In view of the above, the invention provides a long-acting moisturizing cream and a preparation method thereof, and the long-acting moisturizing cream can form effective coating and retention on the surface layer of skin through a prepared microcapsule material with a slow-release structure, so that moisturizing performance and duration are prolonged.
According to the embodiment of the first aspect of the invention, the long-acting moisturizing face cream comprises the following substances in parts by weight: oil phase: 45-50 parts of chinaroot greenbrier seed oil; 15-20 parts of light liquid paraffin; 3-5 parts of polydimethylsiloxane; 1-2 parts of cetearyl alcohol; 15-20 parts of modified microcapsule particles; water phase: 55-60 parts of deionized water; 15-20 parts of glycerol; 6-8 parts of sodium hyaluronate; 6-8 parts of chitosan; the modified microcapsule is prepared by taking maltodextrin as a wall material and monoglyceride and algal polysaccharide as core materials through spray drying.
According to the long-acting moisturizing facial cream provided by the embodiment of the invention, the wall material prepared from maltodextrin and the microcapsule prepared from the core material prepared from monoglyceride and algal polysaccharide are modified, the moisturizing component in the moisturizing facial cream material exists in the form of a slow-release capsule due to the filling of the microcapsule structure, the algal polysaccharide is continuously released for moisturizing modification after use, and the algal polysaccharide can continuously adsorb water to form a saturated state, so that the water absorbed in the algal polysaccharide is sufficiently released after the release, so that more water can be absorbed on the surface layer of the skin, on the basis, the water-soluble micromolecular polysaccharide and the polysaccharide with sulfate groups contained in the algal polysaccharide can exert better antioxidant activity, the antioxidant property of the polysaccharides is enhanced along with the increase of the concentration, and the micromolecular saccharide of the algal is preferentially combined with water in the actual use process, the protein is removed from a solvation layer of protein molecules, so that the molecular structure and conformation of the protein are more stable, and the damage of the external environment to the skin of a human body is reduced, thereby protecting the dermis of the human body, reducing the release and the loss of water and further improving the moisturizing performance.
The long-acting moisturizing facial cream provided by the embodiment of the invention can also have the following additional technical characteristics:
according to one embodiment of the invention, the modified microcapsule wall material further comprises silk fibroin.
According to one embodiment of the invention, the modified microcapsule is prepared by the following steps: s1, freeze-drying seaweed, grinding and sieving, leaching in a water bath by taking a methanol water solution as a leaching solution, carrying out centrifugal separation, taking supernatant, precipitating with absolute ethyl alcohol, removing precipitate and collecting to obtain a modified solution; s2, adding monoglyceride into the dissolved solution, adding the modified solution into the dispersed slurry after ultrasonic dispersion, and carrying out primary homogenization treatment to obtain a homogeneous solution; s3, stirring and mixing silk fibroin and maltodextrin, grinding and sieving, collecting sieved particles, stirring and mixing with deionized water, carrying out secondary homogenization treatment and spray drying, and collecting modified microcapsule particles.
According to an embodiment of the present invention, the seaweed in step S1 is a mixture of one or more of brown algae, red algae and blue-green algae.
According to an embodiment of the invention, the dissolving solution in the step S2 is a mixture of tea seed oil and linseed oil in a mass ratio of 1: 1.
According to an embodiment of the present invention, the primary homogenizing treatment in step S2 is performed at 2500-3000 r/min under 15-20 MPa for 3-5 h.
According to an embodiment of the invention, the spray drying in the step S3 is carried out at an intake of 30-35 m3And/h, the air inlet temperature is 150-160 ℃, and the spray drying treatment is carried out at the spray drying speed of 200-300 mL/h.
According to the second aspect of the invention, the preparation method of the long-acting moisturizing facial cream comprises the following preparation steps: s1', respectively weighing 45-50 parts by weight of white chinlon oil, 15-20 parts by weight of light liquid paraffin, 3-5 parts by weight of polydimethylsiloxane, 1-2 parts by weight of cetostearyl alcohol and 15-20 parts by weight of modified microcapsule particles, stirring and mixing, and performing ultrasonic dispersion for 10-15 min at 200-300W to obtain an oil phase; s2', respectively weighing 55-60 parts by weight of deionized water, 15-20 parts by weight of glycerol, 6-8 parts by weight of sodium hyaluronate and 6-8 parts by weight of chitosan, stirring and mixing, and ultrasonically dispersing for 10-15 min under 200-300W to obtain a water phase; s3', slowly dripping the oil phase into the water phase according to the mass ratio of 1:5, stirring, mixing and homogenizing to obtain a homogeneous emulsion, standing for defoaming, and performing ultraviolet sterilization to obtain the long-acting moisturizing facial cream.
According to an embodiment of the present invention, the slowing rate in step S3' is 5 mL/min.
Additional aspects and advantages of the invention will be set forth in part in the description which follows and, in part, will be obvious from the description, or may be learned by practice of the invention.
Drawings
The above and/or additional aspects and advantages of the present invention will become apparent and readily appreciated from the following description of the embodiments, taken in conjunction with the accompanying drawings of which:
fig. 1 is a flowchart of a method for preparing a long-lasting moisturizing facial cream according to the present invention.
Detailed Description
Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the accompanying drawings are illustrative only for the purpose of explaining the present invention, and are not to be construed as limiting the present invention.
The following specifically describes a long-lasting moisturizing-type moisturizing cream according to an embodiment of the present invention with reference to the accompanying drawings.
As shown in fig. 1, the long-acting moisturizing facial cream according to the embodiment of the invention comprises the following substances in parts by weight:
oil phase: 45-50 parts of chinaroot greenbrier seed oil; 15-20 parts of light liquid paraffin; 3-5 parts of polydimethylsiloxane;
1-2 parts of cetearyl alcohol; 15-20 parts of modified microcapsule particles; water phase: 55-60 parts of deionized water; 15-20 parts of glycerol; 6-8 parts of sodium hyaluronate; 6-8 parts of chitosan; the modified microcapsule is prepared by taking maltodextrin as a wall material and monoglyceride and algal polysaccharide as core materials through spray drying.
Therefore, according to the long-acting moisturizing facial cream provided by the embodiment of the invention, the wall material prepared from maltodextrin and the microcapsule prepared from the core material prepared from monoglyceride and algal polysaccharide are modified, the moisturizing component in the moisturizing facial cream material exists in the form of a slow-release capsule due to the filling of the microcapsule structure, the algal polysaccharide is continuously released for moisturizing modification after use, the algal polysaccharide can continuously adsorb water to form a saturated state, so that the water absorbed in the algal polysaccharide is fully released after the release, and more water can be absorbed on the surface layer of the skin, on the basis, the water-soluble micromolecular polysaccharide and the polysaccharide with sulfate groups contained in the algal polysaccharide can exert better antioxidant activity, the antioxidant property of the polysaccharides is enhanced along with the increase of the antioxidant concentration, and the micromolecular saccharides of the algae are preferentially combined with water in the actual use process, the protein is removed from a solvation layer of protein molecules, so that the molecular structure and conformation of the protein are more stable, and the damage of the external environment to the skin of a human body is reduced, thereby protecting the dermis of the human body, reducing the release and the loss of water and further improving the moisturizing performance.
According to one embodiment of the invention, the modified microcapsule wall material further comprises silk fibroin. The microcapsule wall material prepared from silk fibroin can effectively protect and improve the toughness strength and mechanical property of the wall material in the actual use process, on the basis, in the actual slow-release reaction of silk fibroin, due to the slow-release of the core material in the silk fibroin, the silk fibroin is slowly dissolved and filled to the skin surface layer along with the release of the core material, and due to the fact that the nonionic group in the silk fibroin can effectively make the hydrophilicity and improve the water retention property of the silk fibroin, the moisture retention property can be further improved on the basis.
In some embodiments of the present invention, the modified microcapsules are prepared by the steps of: s1, freeze-drying seaweed, grinding and sieving, leaching in a water bath by taking a methanol water solution as a leaching solution, carrying out centrifugal separation, taking supernatant, precipitating with absolute ethyl alcohol, removing precipitate and collecting to obtain a modified solution; s2, adding monoglyceride into the dissolved solution, adding the modified solution into the dispersed slurry after ultrasonic dispersion, and carrying out primary homogenization treatment to obtain a homogeneous solution; s3, stirring and mixing silk fibroin and maltodextrin, grinding and sieving, collecting sieved particles, stirring and mixing with deionized water, carrying out secondary homogenization treatment and spray drying, and collecting modified microcapsule particles.
Further, the seaweed in step S1 is one or more of brown algae, red algae and blue-green algae. Firstly, brown algae, red dates and blue-green algae are adopted, and the extracted polysaccharide is micromolecular sugar, so that more water can be absorbed to form a saturated state, moisture can be effectively preserved, and a good long-acting moisture preservation effect is achieved.
Optionally, the dissolving solution in step S2 is a tea seed oil and linseed oil solution mixed in a mass ratio of 1: 1. The monoglyceride can be fully dissolved by preparing the compounded tea seed oil and linseed oil, and meanwhile, the tea seed oil and the linseed oil are cheap and easy to obtain, so that the preparation cost can be reduced.
In some embodiments of the present invention, the primary homogenizing treatment in step S2 is performed at 2500-3000 r/min under 15-20 MPa for 3-5 h. Through homogeneity under suitable pressure environment, owing to make various materials carry out abundant mixing and stirring under high-pressure environment, prevent that high pressure from making the liquid material receive powerful shearing force to increase when flowing through narrow gap at a high speed, the stability of polysaccharide emulsion is destroyed to the unnecessary heat that arouses, causes spray drying embedding rate to descend to the dissolving material flash mixed who enables the preparation becomes homodisperse's architecture.
According to an embodiment of the invention, the spray drying in the step S3 is carried out at an intake of 30-35 m3And/h, the air inlet temperature is 150-160 ℃, and the spray drying treatment is carried out at the spray drying speed of 200-300 mL/h. The spray drying treatment scheme can ensure that the microcapsule material has uniform size and a system structure with uniform particle size is formed, thereby improving the uniform and stable performance of the prepared microcapsule.
According to the second aspect of the invention, the preparation method of the long-acting moisturizing facial cream comprises the following preparation steps: s1', respectively weighing 45-50 parts by weight of white chinlon oil, 15-20 parts by weight of light liquid paraffin, 3-5 parts by weight of polydimethylsiloxane, 1-2 parts by weight of cetostearyl alcohol and 15-20 parts by weight of modified microcapsule particles, stirring and mixing, and performing ultrasonic dispersion for 10-15 min at 200-300W to obtain an oil phase; s2', respectively weighing 55-60 parts by weight of deionized water, 15-20 parts by weight of glycerol, 6-8 parts by weight of sodium hyaluronate and 6-8 parts by weight of chitosan, stirring and mixing, and ultrasonically dispersing for 10-15 min under 200-300W to obtain a water phase; s3', slowly dripping the oil phase into the water phase according to the mass ratio of 1:5, stirring, mixing and homogenizing to obtain a homogeneous emulsion, standing for defoaming, and performing ultraviolet sterilization to obtain the long-acting moisturizing facial cream.
In some embodiments of the present invention, the slowing of step S3' is 5 mL/min. Through the scheme of slow stirring, the oil phase and the water phase can be effectively combined and dispersed well, and meanwhile, the low-speed scheme can reduce the damage of the microcapsule material under high-speed stirring, so that the integrity of the whole cream material is improved.
In summary, the microcapsule prepared by the wall material prepared by maltodextrin and the core material prepared by monoglyceride and algal polysaccharide is modified, the moisturizing component in the moisturizing cream material exists in the form of slow-release capsules due to the filling of the microcapsule structure, the algal polysaccharide is continuously released for moisturizing modification after use, and the algal polysaccharide can continuously adsorb water to form a saturated state, so that the water absorbed in the algal polysaccharide is fully released after the release, and the skin surface layer can absorb more water, on the basis, the water-soluble micromolecule polysaccharide and the polysaccharide with sulfate groups contained in the algal polysaccharide can exert better antioxidant activity, the antioxidant property of the polysaccharides is enhanced along with the increase of the concentration, and in the actual use process, the micromolecule saccharides of the algae are preferentially combined with water and are removed from the solvent layer of protein molecules, the molecular structure and conformation of the protein are more stable, and the damage of the external environment to the skin of the human body is reduced, so that the dermis layer of the human body is protected, the release and the loss of moisture are reduced, and the moisturizing performance is further improved.
Secondly, the microcapsule wall material is prepared from silk fibroin according to the technical scheme of the invention, and the toughness strength and mechanical property of the wall material can be effectively protected and improved in the actual use process, on the basis, in the actual slow release reaction of the silk fibroin, due to the slow release of the core material in the silk fibroin, the silk fibroin is slowly dissolved and filled to the skin surface layer along with the release of the core material, and due to the fact that the nonionic group in the silk fibroin can effectively make the hydrophilicity and improve the water retention property of the silk fibroin, the moisture retention property can be further improved on the basis.
The following will explain in detail the preparation method of the long-acting moisturizing facial cream of the embodiment of the present invention with reference to specific examples.
Example 1
Taking brown algae, red algae and blue-green algae, freeze-drying, grinding and sieving with a 500-mesh sieve after drying, collecting sieved particles, adding the sieved particles into a methanol water solution according to a mass ratio of 1:25, carrying out water bath treatment at 45 ℃ for 2 hours, carrying out centrifugal separation at 7800r/min for 20min, standing for precipitation, collecting supernatant, stirring and mixing the supernatant with absolute ethyl alcohol according to a volume ratio of 1:5, standing for precipitation, carrying out centrifugal separation at 10000r/min for 20min, and collecting the supernatant to obtain a modified solution;
taking monoglyceride, adding the monoglyceride into a dissolving solution according to the mass ratio of 1:5, stirring and mixing the dissolving solution which is a tea seed oil solution and a linseed oil solution mixed according to the mass ratio of 1:1, placing the mixture at room temperature for ultrasonic dispersion for 10min, collecting dispersed slurry, adding a modified solution into the dispersed slurry according to the volume ratio of 1:5, stirring and mixing the mixture, placing the mixture under 2500r/min and 15MPa for homogenization treatment for 3h, and collecting a homogenized solution;
stirring and mixing silk fibroin and maltodextrin according to a mass ratio of 1:3, grinding and sieving with a 500-mesh sieve, collecting sieved particles, stirring and mixing the sieved particles with deionized water according to a mass ratio of 1:5, collecting mixed liquid, adding the homogenized liquid into the mixed liquid according to a mass ratio of 1:10, homogenizing at 3MPa for 1h, collecting secondary homogenized liquid, placing the secondary homogenized liquid into a spray drying device, spray drying and collecting dried particles, controlling the air inlet amount to be 30m3/h, the air inlet temperature to be 150-160 ℃, and the spray drying rate to be 200mL/h, and collecting modified microcapsule particles;
respectively weighing 45 parts of white chinlon oil, 15 parts of light liquid paraffin, 3 parts of polydimethylsiloxane, 1 part of cetostearyl alcohol and 15 parts of modified microcapsule particles according to parts by weight, stirring and mixing, and performing ultrasonic dispersion for 10min at 200W to obtain an oil phase;
respectively weighing 55 parts by weight of deionized water, 15 parts by weight of glycerol, 6 parts by weight of sodium hyaluronate and 6 parts by weight of chitosan, stirring and mixing, and performing ultrasonic dispersion for 10min at 200W to obtain a water phase;
and (3) dropwise adding the oil phase into the water phase at the speed of 5mL/min according to the mass ratio of 1:5, stirring, mixing, homogenizing at 5000r/min for 6h to obtain a homogeneous emulsion, standing, defoaming and performing ultraviolet sterilization to obtain the long-acting moisturizing facial cream.
Example 2
Taking brown algae, red algae and blue-green algae, freeze-drying, grinding and sieving with a 500-mesh sieve after drying, collecting sieved particles, adding the sieved particles into a methanol water solution according to a mass ratio of 1:25, carrying out water bath treatment at 50 ℃ for 2 hours, carrying out centrifugal separation at 8000r/min for 25min, standing for precipitation, collecting supernatant, stirring and mixing the supernatant with absolute ethyl alcohol according to a volume ratio of 1:5, standing for precipitation, carrying out centrifugal separation at 12500r/min for 25min, and collecting the supernatant to obtain a modified solution;
taking monoglyceride, adding the monoglyceride into a dissolving solution according to the mass ratio of 1:5, stirring and mixing the dissolving solution which is a tea seed oil solution and a linseed oil solution mixed according to the mass ratio of 1:1, placing the mixture at room temperature for ultrasonic dispersion for 12min, collecting dispersed slurry, adding a modified solution into the dispersed slurry according to the volume ratio of 1:5, stirring and mixing the mixture, placing the mixture under 2752r/min and 17MPa for homogenization treatment for 4h, and collecting a homogenized solution;
stirring and mixing silk fibroin and maltodextrin according to a mass ratio of 1:3, grinding and sieving with a 500-mesh sieve, collecting sieved particles and stirring and mixing the sieved particles with deionized water according to a mass ratio of 1:5, collecting mixed liquid and adding the homogenized liquid into the mixed liquid according to a mass ratio of 1:10, homogenizing under 4MPa for 1h, collecting secondary homogenized liquid and placing the secondary homogenized liquid in a spray drying device, spray drying and collecting dried particles, controlling the air inlet amount to be 32m3/h, the air inlet temperature to be 155 ℃, and the spray drying rate to be 250mL/h, and collecting modified microcapsule particles;
respectively weighing 47 parts by weight of white chinlon oil, 17 parts by weight of light liquid paraffin, 4 parts by weight of polydimethylsiloxane, 1 part by weight of cetostearyl alcohol and 17 parts by weight of chitosan, respectively weighing 57 parts by weight of deionized water, 17 parts by weight of glycerol, 7 parts by weight of sodium hyaluronate and 7 parts by weight of chitosan, stirring and mixing, and performing ultrasonic dispersion at 250W for 12min to obtain a water phase;
and (3) dropwise adding the oil phase into the water phase at the speed of 5mL/min according to the mass ratio of 1:5, stirring and mixing, homogenizing at 6500r/min for 7h to obtain a homogeneous emulsion, standing for defoaming, and performing ultraviolet sterilization to obtain the long-acting moisturizing facial cream.
Example 3
Taking brown algae, red algae and blue-green algae, freeze-drying, grinding and sieving with a 500-mesh sieve after drying, collecting sieved particles, adding the sieved particles into a methanol water solution according to a mass ratio of 1:25, carrying out water bath treatment at 55 ℃ for 3 hours, then carrying out centrifugal separation at 8500r/min for 30min, standing and precipitating, collecting supernatant, stirring and mixing the supernatant with absolute ethyl alcohol according to a volume ratio of 1:5, standing and precipitating, placing and carrying out centrifugal separation at 15000r/min for 30min, and collecting the supernatant to obtain a modified solution;
taking monoglyceride, adding the monoglyceride into a dissolving solution according to the mass ratio of 1:5, stirring and mixing the dissolving solution which is a tea seed oil solution and a linseed oil solution mixed according to the mass ratio of 1:1, placing the mixture at room temperature for ultrasonic dispersion for 15min, collecting dispersed slurry, adding a modified solution into the dispersed slurry according to the volume ratio of 1:5, stirring and mixing the mixture, placing the mixture under 3000r/min and 20MPa for homogenization treatment for 5h, and collecting a homogenized solution;
stirring and mixing silk fibroin and maltodextrin according to a mass ratio of 1:3, grinding and sieving with a 500-mesh sieve, collecting sieved particles and stirring and mixing the sieved particles with deionized water according to a mass ratio of 1:5, collecting mixed liquid and adding the homogenized liquid into the mixed liquid according to a mass ratio of 1:10, homogenizing at 5MPa for 2 hours, collecting secondary homogenized liquid and placing the secondary homogenized liquid in a spray drying device, spray drying and collecting dried particles, controlling the air inlet amount to be 35m3/h, the air inlet temperature to be 160 ℃, and the spray drying rate to be 300mL/h, and collecting modified microcapsule particles;
respectively weighing 50 parts of meadowfoam seed oil, 20 parts of light liquid paraffin, 5 parts of polydimethylsiloxane, 2 parts of cetostearyl alcohol and 20 parts of modified microcapsule particles according to parts by weight, stirring and mixing, and performing ultrasonic dispersion for 15min at 300W to obtain an oil phase;
respectively weighing 60 parts by weight of deionized water, 20 parts by weight of glycerol, 8 parts by weight of sodium hyaluronate and 8 parts by weight of chitosan, stirring and mixing, and performing ultrasonic dispersion for 15min at 300W to obtain a water phase;
and (3) dropwise adding the oil phase into the water phase at the speed of 5mL/min according to the mass ratio of 1:5, stirring and mixing, homogenizing at 8000r/min for 8h to obtain a homogeneous emulsion, standing for defoaming, and performing ultraviolet sterilization to obtain the long-acting moisturizing facial cream.
Examples 4 to 5
The pressure and the rotation speed of the primary homogenization treatment in the preparation process of the long-acting moisturizing facial cream of the examples 4 to 5 are different, and the rest conditions and the component ratios are the same as those in the example 1, and are shown in the table 1.
TABLE 1 parameters of homogenization treatment in examples 1 to 5
Item Example 1 Example 2 Example 3 Example 4 Example 5
Pressure intensity 15 17 20 20 15
Rotational speed/r/min 2500 2752 3000 2500 3000
Performance test
The examples 1 to 5 were respectively subjected to performance tests, specifically testing the appearance, odor, pH value, viscosity and stability of the prepared long-acting moisturizing type moisturizing cream, and only the moisturizing performances of the examples 3 to 5 were tested since the basic schemes of the examples 1 to 3 were the same.
Detection method/test method
Appearance, odor: observation;
pH value: measuring the pH value by using a pH meter, and testing the method: measured according to the method in GB/T13531.1;
viscosity: detecting the viscosity of the mask by using a cosmetic viscometer;
moisture retention: the long-acting moisturizing facial creams prepared in examples 3 to 5 were subjected to human facial skin test, and a digital skin moisture detector (bioelectrical impedance analysis technology) was used to detect the moisture content of the skin, observe the effect thereof, and record data by the method: selecting 12 persons with different sexes, ages, occupations and facial cleaning habits to test, and testing once every three days;
stability: standing and observing
The specific detection results are shown in the following tables 2-5:
TABLE 2 Performance test Table
Figure BDA0002695352320000081
Figure BDA0002695352320000091
Table 3 example 3 moisturizing performance test table
Figure BDA0002695352320000092
Table 4 example 4 moisturizing performance test table
Figure BDA0002695352320000093
Table 5 example 5 moisturizing performance test table
Figure BDA0002695352320000094
Figure BDA0002695352320000101
As can be seen from the performance tests in tables 2 to 5, the moisturizing cream in example 3 has excellent moisturizing performance after use, because in the technical scheme of the present application, through homogenization treatment under a suitable pressure environment, the uniform dispersion performance of the materials is improved because various materials are sufficiently mixed and stirred under a high pressure environment, and thus, the moisturizing cream prepared by the technical scheme in example 3 has long-term improvement performance of the water retention rate each time in the long-term use process, and can finally improve the water retention rate of human skin, so the moisturizing cream adopted in example 3 can have a good moisturizing effect.
Examples 1-5 were compared in performance and the prepared dissolved materials were rapidly mixed into a uniformly dispersed system structure due to homogenization treatment under a suitable pressure environment.
Comparative examples 1 to 5
In contrast to example 3, comparative examples 1-5 and example 3 used different homogenization pressures and the other conditions and components were consistent with example 3.
Comparative example 6
In contrast to example 3, comparative example 6 was compared to example 3, without the addition of modified microcapsule particles, and the other conditions and components were identical to those of example 3.
Performance test
And (3) carrying out performance tests on the comparative examples 1-5, and specifically testing the appearance, smell, pH value, viscosity and stability of the prepared long-acting moisturizing facial cream.
Comparative example 6 was subjected to a performance test to test the moisturizing performance.
Detection method/test method
Appearance, odor: observation;
pH value: measuring the pH value by using a pH meter, and testing the method: measured according to the method in GB/T13531.1;
viscosity: detecting the viscosity of the mask by using a cosmetic viscometer;
stability: after standing for 70-72 h, observing, and specifically testing as shown in the following table 6:
moisture retention: the long-acting moisturizing type moisturizing cream prepared in the comparative example 6 is subjected to human face skin test, a digital skin moisture detector (bioelectrical impedance analysis technology) is used for detecting the moisture rate of the skin, the effect is observed, and data are recorded, wherein the method comprises the following steps: selecting 12 persons with different sexes, ages, occupations and facial cleaning habits to test, and testing once every three days;
the specific test properties are shown in tables 6 and 7 below:
TABLE 6 Performance test Table
Figure BDA0002695352320000111
Table 7 moisture retention test chart
Figure BDA0002695352320000112
Comparing the performances of comparative examples 1-5 with those of example 3, the stability performance is poor, which shows that the stability of the cream material is reduced due to the fact that various materials are fully mixed and stirred under a high-pressure environment, and the problem that the stability of the polysaccharide emulsion is reduced due to the fact that the stability of the polysaccharide emulsion is damaged by excessive heat caused by the increase of strong shearing force when the liquid material flows through a narrow gap at a high speed due to high pressure, and the water retention performance of the microcapsule material is reduced and the stability of the cream material is reduced is caused;
comparing the performance of the comparative example 6 with that of the example 3, the water retention rate of the human skin can be finally improved due to the long-acting improvement performance of the water retention rate each time, so that the water retention rate performance of the comparative example 6 has a significant difference compared with that of the example 3, which shows that the water retention performance can be prolonged by adopting the scheme of the microcapsule material.
In the description herein, references to the description of the term "one embodiment," "some embodiments," "an illustrative embodiment," "an example," "a specific example," or "some examples" or the like mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
While embodiments of the invention have been shown and described, it will be understood by those of ordinary skill in the art that: various changes, modifications, substitutions and alterations can be made to the embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the claims and their equivalents.

Claims (9)

1. The long-acting moisturizing face cream is characterized by comprising the following substances in parts by weight:
Figure FDA0002695352310000011
6-8 parts of chitosan; the modified microcapsule is prepared by taking maltodextrin as a wall material and monoglyceride and algal polysaccharide as core materials through spray drying.
2. The long-acting moisturizing cream of claim 1, wherein the modified microcapsule wall material further comprises silk fibroin.
3. The long-acting moisturizing cream according to claim 2, wherein the modified microcapsules are prepared by the steps of:
s1, freeze-drying seaweed, grinding and sieving, leaching in a water bath by taking a methanol water solution as a leaching solution, carrying out centrifugal separation, taking supernatant, precipitating with absolute ethyl alcohol, removing precipitate and collecting to obtain a modified solution;
s2, adding monoglyceride into the dissolved solution, adding the modified solution into the dispersed slurry after ultrasonic dispersion, and carrying out primary homogenization treatment to obtain a homogeneous solution;
s3, stirring and mixing silk fibroin and maltodextrin, grinding and sieving, collecting sieved particles, stirring and mixing with deionized water, carrying out secondary homogenization treatment and spray drying, and collecting modified microcapsule particles.
4. The long-acting moisturizing cream of claim 3, wherein the seaweed of step S1 is a mixture of one or more of brown algae, red algae, and blue-green algae.
5. The long-acting moisturizing facial cream according to claim 3, wherein the dissolving solution of step S2 is a mixture of tea seed oil and linseed oil at a mass ratio of 1: 1.
6. The long-acting moisturizing face cream according to claim 3, wherein the primary homogenization treatment in step S2 is performed at 2500-3000 r/min under 15-20 MPa for 3-5 h.
7. The long-acting moisturizing face cream according to claim 3, wherein the spray drying in step S3 is performed at an intake rate of 30-35 m3And/h, the air inlet temperature is 150-160 ℃, and the spray drying treatment is carried out at the spray drying speed of 200-300 mL/h.
8. A preparation method of long-acting moisturizing facial cream is characterized by comprising the following preparation steps:
s1', respectively weighing 45-50 parts by weight of white chinlon oil, 15-20 parts by weight of light liquid paraffin, 3-5 parts by weight of polydimethylsiloxane, 1-2 parts by weight of cetostearyl alcohol and 15-20 parts by weight of modified microcapsule particles, stirring and mixing, and performing ultrasonic dispersion for 10-15 min at 200-300W to obtain an oil phase;
s2', respectively weighing 55-60 parts by weight of deionized water, 15-20 parts by weight of glycerol, 6-8 parts by weight of sodium hyaluronate and 6-8 parts by weight of chitosan, stirring and mixing, and ultrasonically dispersing for 10-15 min under 200-300W to obtain a water phase;
s3', slowly dripping the oil phase into the water phase according to the mass ratio of 1:5, stirring, mixing and homogenizing to obtain a homogeneous emulsion, standing for defoaming, and performing ultraviolet sterilization to obtain the long-acting moisturizing facial cream.
9. The method of preparing a long-acting moisturizing cream according to claim 8, wherein the slowing of step S3' is 5 mL/min.
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CN112353740A (en) * 2020-12-04 2021-02-12 天津强微特生物科技有限公司 Nail-protecting composition, nail-protecting hand cream and preparation method thereof
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CN117599247A (en) * 2023-12-14 2024-02-27 浙江来益美生物医药有限公司 Silk fibroin microcarrier skin filling preparation, and preparation method and application thereof
CN117599247B (en) * 2023-12-14 2024-05-31 浙江来益美生物医药有限公司 Silk fibroin microcarrier skin filling preparation, and preparation method and application thereof

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