CN111973147B - Eyelid pressure detection device - Google Patents
Eyelid pressure detection device Download PDFInfo
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- CN111973147B CN111973147B CN202010682413.8A CN202010682413A CN111973147B CN 111973147 B CN111973147 B CN 111973147B CN 202010682413 A CN202010682413 A CN 202010682413A CN 111973147 B CN111973147 B CN 111973147B
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- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
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Abstract
The invention provides an eyelid pressure detection device, which comprises a cornea contact lens which is put on the surface of an eyeball and is attached to the cornea; the system comprises a strain induction sensor and a signal processing module, wherein the strain induction sensor is arranged in the cornea contact lens and is used for detecting the strain quantity generated when an upper eyelid acts on the cornea contact lens when blinking, and the signal processing module is arranged in the cornea contact lens and is connected with the strain induction sensor and is used for converting the strain quantity detected by the strain induction sensor into an electric signal and transmitting the electric signal to an external device; the detection device can accurately measure the eyelid pressure, reduce the interference of intraocular pressure on eyelid pressure during detection, and improve the accuracy and repeatability of eyelid pressure detection.
Description
Technical Field
The invention belongs to the technical field of instruments for measuring eyelid pressure, and particularly relates to an eyelid pressure detection device.
Background
Structural and functional abnormalities of the eyelid can cause ocular surface dysfunction. Eyelid pressure refers to the tension or pressure applied by the eyelid to the conjunctiva and cornea. The shear force and slippage of the eyelid on the ocular surface during the transient process has an effect on the stability of the tear film, the tear fluid volume, conjunctival and corneal epithelial cells and conjunctival goblet cells. Since shear force is difficult to quantitatively measure, eyelid pressure is often measured to assess abnormalities in eyelid function. There is currently no standard eyelid pressure measuring device. There are significant variations in the eyelid pressure measured by different measurement methods and devices, resulting in poor accuracy and repeatability of eyelid pressure detection.
Disclosure of Invention
In order to solve the technical problems, the invention provides a novel eyelid pressure detection device.
One of the technical solutions of the present invention provides an eyelid pressure detection device, the detection device comprising:
a contact lens which is placed on the surface of the eyeball and is attached to the cornea;
a strain sensor disposed in the contact lens for detecting an amount of strain generated when the upper eyelid acts on the contact lens when blinking;
the signal processing module is configured in the cornea contact lens, connected with the strain induction sensor and used for converting the strain quantity detected by the strain induction sensor into an electric signal and transmitting the electric signal to an external device.
In a further refinement, the contact lens is configured as a bilayer structure comprising an inner layer structure that conforms to the cornea and an outer layer structure that conforms to the eyelid.
In the further improved scheme, the edge pressfitting all around of inlayer structure and outer structure forms first cavity, be equipped with the first deformation membrane of following pressure deformation in the first cavity, first deformation membrane divide into first sealing area and second sealing area with first cavity, first sealing area is close to inlayer structure and outer structure's edge, be equipped with transparent liquid in the first sealing area.
In a further development, the radius of curvature of the inner layer structure is identical to the radius of curvature of the cornea, and the radius of curvature of the outer layer structure is greater than the radius of curvature of the cornea.
In a further development, the radius of curvature r of the outer layer structure 1 Radius of curvature r with the inner layer structure 2 Is of the relation r 1 ＝(1.2-1.5)r 2 。
In a further improved scheme, the strain induction sensor is a Wheatstone bridge, and the Wheatstone bridge consists of four resistors, namely a resistor R 1 Resistance R 2 Resistance R 3 And resistance R X The resistance R 1 Resistance R 2 Resistance R 3 Is a constant value resistor, the resistor R x Is a variable varistor; the resistor R x The resistor R is attached to one side of the first deformation film, which is positioned at the second sealing area, and the width of the resistor R is the same as that of the first deformation film 1 、R 2 And R is 3 Is spirally arranged in the edges of the inner layer structure and the outer layer structure.
In a further development, the contact lens is configured as a three-layer structure, comprising a first layer structure, a second layer structure and a third layer structure, the edges of the first layer structure, the second layer structure and the third layer structure being pressed together; a second cavity is formed between the first layer structure and the second layer structure, and a third cavity is formed between the second layer structure and the third layer structure; the first structure layer and the second structure layer are deformation films deformed along with pressure, the second deformation films deformed along with pressure are arranged in the third cavity, the second deformation films divide the third cavity into a third sealing area and a fourth sealing area, the third sealing area is close to the edges of the second structure layer and the third structure layer, and transparent liquid is arranged in the third sealing area.
In a further improved scheme, the strain induction sensor consists of six resistors, namely a resistor R 4 Resistance R 5 Resistance R 6 Resistance R a Resistance R b And resistance R c The resistance R 4 Resistance R 5 And resistance R 6 For a constant resistance, resistance R a Resistance R b And resistance R c Is a variable varistor.
In a further development, the resistor R a Embedded in the first layer structure, the length is the same as that of the second cavity, and the resistor R b Embedded in the second layer structure, the length is the same as that of the second cavity, and the resistor R c The second deformation film is attached to one side of the fourth sealing area; the resistor R 4 Resistance R 5 Resistance R 6 The circular shape is arranged in the edges of the first layer structure, the second layer structure and the third layer structure.
In a further improved aspect, the external device includes:
the receiving module is used for receiving the pressure data transmitted by the signal processing module;
a calculation module for calculating eyelid pressure Y according to the following formula;
y=y1- (Y2-Y3), Y1 being the resistance R c Pressure data generated after the change, Y2 is resistance R a Pressure data generated after the change, Y3 is resistance R b Pressure data generated after the change;
and the display module is used for displaying the calculated eyelid pressure Y.
Compared with the prior art, the eyelid pressure detection device provided by the invention has the advantages that: according to the eyelid pressure detection device, the structure of the cornea contact lens is limited, the Wheatstone bridge serving as the strain induction sensor is embedded into the cornea contact lens, so that the eyelid pressure can be accurately measured, the interference of intraocular pressure on the eyelid pressure during detection is reduced, and the accuracy and repeatability of eyelid pressure detection are improved.
Drawings
Fig. 1 is a bottom view of an eyelid pressure detection device;
fig. 2 is a cross-sectional view of a longitudinal section of the eyelid pressure detection device;
FIG. 3 is a schematic diagram of a strain sensitive sensor in some embodiments;
FIG. 4 is a cross-sectional view of a contact lens;
FIG. 5 is a longitudinal cross-sectional view of a connection of the second layer structure and the third layer structure;
FIG. 6 is a schematic diagram of a strain sensitive sensor in other embodiments.
Detailed Description
The invention will be described in further detail with reference to the accompanying drawings and the following examples.
Some embodiments of the present invention provide an eyelid pressure detection device, comprising:
a contact lens which is placed on the surface of the eyeball and is attached to the cornea; wherein, the cornea contact lens is made of silicon hydrogel and hydrated polymer selected from methyl methacrylate, hydroxyethyl methacrylate or glyceride methacrylate; the diameter of the cornea contact lens is preferably 10-15mm, and the thickness is less than 0.2mm;
a strain sensor disposed in the contact lens for detecting an amount of strain generated when the upper eyelid acts on the contact lens when blinking;
the signal processing module is configured in the cornea contact lens, connected with the strain induction sensor and used for converting the strain quantity detected by the strain induction sensor into an electric signal and transmitting the electric signal to an external device.
The strain-sensing sensor and the signal processing module are both embedded in the contact lens by known methods, for example, the strain-sensing sensor and the signal processing module can be embedded in the contact lens by microelectronic processes. The cornea contact lens is also used for sealing the strain induction sensor and the signal processing module, so that the cornea contact lens can work stably.
The signal processing module utilized in the present application is of known construction, comprising: the LC power unit for taking external power and the microelectronics ASIC (Appl icat ion Spec ificIntegrated Circuit) are integrated with a chip.
The microelectronic ASIC integrated chip 7 includes:
the digital-to-analog conversion unit is used for converting the received analog signals into digital signals;
a radio frequency unit for transmitting the digital signal to an external device;
a power management unit for stabilizing the voltage and distributing the voltage;
the strain sensing circuit is respectively connected with the power management unit and the analog signal receiving end of the digital-to-analog conversion unit; the digital signal transmitting end of the digital-to-analog conversion unit is connected with the radio frequency unit; the power management unit is respectively connected with the digital-to-analog conversion unit, the radio frequency unit and the LC energy supply unit. The signal processing module obtains the tiny electric signal collected by the strain sensor, and processes and transmits the tiny electric signal through the microelectronic integrated chip, and the microelectronic integrated chip mainly comprises a signal amplifying circuit, an ADC chip for converting analog signals into digital signals, and a radio frequency chip for transmitting the converted digital signals. The LC energy supply unit matching circuit is used for collecting and storing energy, the structure of the LC energy supply unit matching circuit can be round, the diameter of the LC energy supply unit matching circuit is preferably 8-10mm, and the diameter of an inductance wire circle in the LC energy supply unit is larger than that of a measuring resistance coil. The power management unit also has the function of storing electrical energy.
In some preferred embodiments, the external device is disposed on external glasses, or is a smart terminal or computer independently disposed for displaying eyelid pressure.
As shown in fig. 1, in some preferred embodiments, the contact lens is generally spherical and configured as a double layer structure comprising an inner layer structure 10 conforming to the cornea and an outer layer structure 20 conforming to the eyelid, the inner layer structure 10 having a radius of curvature equal to the radius of curvature of the cornea, the outer layer structure 20 having a radius of curvature greater than the radius of curvature of the cornea, preferably the outer layer structure 20 having a radius of curvature r 1 Radius of curvature r with inner layer structure 10 2 Is of the relation r 1 ＝1.3r 2 . By defining the radii of curvature of the inner and outer structures 10, 20, the equilibrium pressure exerted by the ocular content on the eye wall can be reduced, thereby improving the accuracy of eyelid pressure detection.
As shown in fig. 2, the peripheral edges of the inner layer structure 10 and the outer layer structure 20 are pressed together to form a first cavity, wherein the first cavity corresponds to the upper eyelid, and does not correspond to the lower eyelid, i.e., the inner layer structure 10 and the outer layer structure 20 corresponding to the lower eyelid are in a tightly pressed form. The first cavity is internally provided with a first deformation film 30 deformed along with pressure, the first deformation film 30 divides the first cavity into a first sealing area 41 and a second sealing area 42, the first sealing area 41 is close to the edges of the inner layer structure 10 and the outer layer structure 20, and transparent liquid, preferably water, is arranged in the first sealing area 41.
As shown in fig. 3, the strain-sensing sensor is a wheatstone bridge composed of four resistors, each resistor R 1 Resistance R 2 Resistance R 3 And resistance R X Wherein the resistance R 1 Resistance R 2 Resistance R 3 For a constant resistance, resistance R x Is a variable varistor. With continued reference to FIG. 2, the strain sensitive sensor is arranged in the following manner: resistor R x The first deformable membrane 30 is attached to one side of the second sealing region 50 and has the same width as the first deformable membrane 30, preferably 2-10 μm; resistor R 1 、R 2 And R is 3 Is spirally disposed within the edges of the inner layer structure 10 and the outer layer structure 20. Wherein the resistance R 1 Resistance of resistorR 2 Resistance R 3 And resistance R x The connecting structures are all made of high-sensitivity polymer or metal materials, are preferably made of graphene materials, and the width of the connecting structures is preferably 2-10 mu m. Graphene is almost transparent as a flexible material.
The principle of the strain sensitive sensor is as follows: when the resistance values of the four resistors are equal, the strain induction sensor is in an equilibrium state, and when blinking, the upper eyelid can drive liquid in the first sealing area to flow, and the flow of the liquid can deform the first deformation mould; thereby making R x The change in resistance at this time reflects the amount of strain that is generated when the upper eyelid is applied to the contact lens, and a minute electrical signal is generated.
With continued reference to fig. 2, the signal processing module 60 is placed in close compression.
The pressure of the eyelid can be accurately measured by limiting the structure of the cornea contact lens and arranging the Wheatstone bridge serving as the strain sensing sensor to be embedded into the cornea contact lens, so that the interference of intraocular pressure on the eyelid pressure during detection is reduced, and the accuracy and repeatability of eyelid pressure detection are improved.
As shown in fig. 4, in some preferred embodiments, the contact lens is configured as a three-layer structure comprising a first layer 51, a second layer 52, and a third layer 53, the first layer 51 conforming to the cornea, the second layer 52 being positioned between the first layer 51 and the third layer 53, the third layer 53 conforming to the eyelid, the edges of the first layer 51, the second layer 52, and the third layer 53 being in compression; a second cavity 54 is formed between the first layer structure 51 and the second layer structure 52, a third cavity 55 is formed between the second layer structure 52 and the third layer structure 53, the third cavity 55 corresponds to the upper eyelid and does not correspond to the lower eyelid, that is, the second layer structure 52 and the third layer structure 53 corresponding to the lower eyelid are in a tight press fit form. The first layer structure 51 and the second layer structure 52 are deformation films deformed according to pressure, as shown in fig. 5, a second deformation film 56 deformed according to pressure is disposed in the third cavity 55, the second deformation film 56 divides the third cavity 55 into a third sealing area 57 and a fourth sealing area 58, the third sealing area 57 is close to the edges of the second layer structure 52 and the third layer structure 53, and transparent liquid, preferably water, is disposed in the third sealing area 57.
In some preferred embodiments, the strain sensitive sensor is composed of six resistors, each resistor R 4 Resistance R 5 Resistance R 6 Resistance R a Resistance R b And resistance R c Wherein the resistance R 4 Resistance R 5 And resistance R 6 For a constant resistance, resistance R a Resistance R b And resistance R c Is a variable varistor. The six resistors are preferably made of graphene material. See fig. 6 for the connection of six resistors.
The setting mode of the strain induction sensor is as follows: resistor R a Embedded in the first layer structure 51 and having the same length as the second cavity, the resistor R b Embedded in the second layer structure 52, the length of which is the same as the length of the second cavity, the resistor R c Attached to the second deformable membrane 56 on one side of the fourth sealing region 58; resistor R 4 Resistance R 5 Resistance R 6 The circular shape is arranged in the edges of the first layer structure, the second layer structure and the third layer structure.
The principle of the strain sensitive sensor is as follows: when the resistance values of the six resistors are equal, the strain induction sensor is in a balanced state, and when the eyes blink, the content of the eyeballs can act on the first layer structure and the second layer structure, and as the second cavity is arranged between the first layer structure and the second layer structure, the deformation amounts of the first layer structure and the second layer structure are different, and then the resistor R is formed a And resistance R b Changes occur; the upper eyelid will drive the liquid in the third sealing area to flow, the flow of the liquid will deform the second deforming die, and further the resistor R will be formed c Change in resistance R a Resistance R b And resistance R c The change in (2) reflects the amount of strain created by the contents of the eye and the upper eyelid when applied to the contact lens, and a minute electrical signal is produced.
Because the cornea contact lens is placed on the surface of the eyeball, the eyeball can generate acting force on the cornea contact lens so as to further influence the detection of eyelid pressure, the cornea contact lens with a special structure is arranged for improving the accuracy of eyelid pressure detection, and the structure of the strain sensing sensor is improved to a certain extent, so that the pressure of the eyeball on the cornea contact lens can be detected, and further, the eyelid pressure can be corrected, and the detection accuracy of the cornea contact lens is improved.
The external device includes:
the receiving module is used for receiving the pressure data transmitted by the signal processing module;
a calculation module for calculating eyelid pressure Y according to the following formula,
y=y1- (Y2-Y3), Y1 being the resistance R c Pressure data generated after the change, Y2 is resistance R a Pressure data generated after the change, Y3 is resistance R b Pressure data generated after the change;
and the display module is used for displaying the calculated eyelid pressure Y.
The external device is specifically limited, and accuracy of eyelid pressure detection is improved.
Claims (10)
1. An eyelid pressure detection device, the detection device comprising:
a contact lens which is placed on the surface of the eyeball and is attached to the cornea; wherein, a cavity corresponding to the upper eyelid is arranged in the cornea contact lens; a deformation film which deforms along with pressure is arranged in the cavity; the deformation film divides the cavity into a sealing area provided with transparent liquid and a sealing area provided with a piezoresistor of the strain sensor;
a strain sensor disposed in the contact lens for detecting a strain amount generated by deformation of the deformation film due to a flow of a liquid in a sealing region where a transparent liquid is provided when the upper eyelid is applied to the contact lens during blinking;
the signal processing module is configured in the cornea contact lens, connected with the strain induction sensor and used for converting the strain quantity detected by the strain induction sensor into an electric signal and transmitting the electric signal to an external device.
2. The eyelid pressure detection device of claim 1, wherein the contact lens is configured as a double layer structure comprising an inner layer structure that conforms to the cornea and an outer layer structure that conforms to the eyelid, the peripheral edges of the inner and outer layer structures being pressed together to form the cavity.
3. The eyelid pressure detection device of claim 2, wherein the sealing region provided with transparent liquid is proximate to edges of the inner and outer structures.
4. The eyelid pressure detection device of claim 2, wherein the radius of curvature of the inner layer structure is the same as the radius of curvature of the cornea, and wherein the radius of curvature of the outer layer structure is greater than the radius of curvature of the cornea.
5. The eyelid pressure detection device of claim 2 wherein said outer layer structure has a radius of curvature r 1 Radius of curvature r with the inner layer structure 2 Is of the relation r 1 =1.2r 2 ～1.5r 2 。
6. The eyelid pressure detection device of claim 3, wherein the strain sensitive sensor is a wheatstone bridge consisting of four resistors, each resistor R 1 Resistance R 2 Resistance R 3 And resistance R X The resistance R 1 Resistance R 2 Resistance R 3 Is a constant value resistor, the resistor R x Is a variable varistor; the resistor R x The width is the same as the width of the deformation film, the resistance R 1 、R 2 And R is 3 Is spirally arranged in the edges of the inner layer structure and the outer layer structure.
7. The eyelid pressure detection device of claim 1, wherein the corneal contact lens is configured as a three-layer structure comprising a first layer structure, a second layer structure, and a third layer structure, the edges of the first layer structure, the second layer structure, and the third layer structure being press-fit; a second cavity is formed between the first layer structure and the second layer structure, and the cavity is formed between the second layer structure and the third layer structure; the first layer structure and the second layer structure are deformation films which deform along with pressure, and the sealing area provided with transparent liquid is close to the edges of the second layer structure and the third layer structure.
8. The eyelid pressure detection device of claim 7, wherein the strain sensitive sensor is comprised of six resistors, resistor R 4 Resistance R 5 Resistance R 6 Resistance R a Resistance R b And resistance R c The resistance R 4 Resistance R 5 And resistance R 6 For a constant resistance, resistance R a Resistance R b And resistance R c Is a variable varistor.
9. The eyelid pressure detection device of claim 8, wherein the resistor R a Embedded in the first layer structure, the length is the same as that of the second cavity, and the resistor R b Embedded in the second layer structure, the length is the same as that of the second cavity, and the resistor R c A deformable membrane attached to a cavity formed between the second layer structure and the third layer structure; the resistor R 4 Resistance R 5 Resistance R 6 The circular shape is arranged in the edges of the first layer structure, the second layer structure and the third layer structure.
10. The eyelid pressure detection device of claim 9, wherein the external device comprises:
the receiving module is used for receiving the pressure data transmitted by the signal processing module;
a calculation module for calculating eyelid pressure Y according to the following formula;
y=y1- (Y2-Y3), Y1 being the resistance R c Pressure data generated after the change, Y2 is resistance R a Pressure data generated after the change, Y3 is resistance R b Pressure data generated after the change;
and the display module is used for displaying the calculated eyelid pressure Y.
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| CN202010682413.8A CN111973147B (en) | 2020-07-15 | 2020-07-15 | Eyelid pressure detection device |
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| CN112971702A (en) * | 2021-02-07 | 2021-06-18 | 北京大学第三医院（北京大学第三临床医学院） | Eyelid tension measuring instrument |
| CN116458837B (en) * | 2023-04-24 | 2023-09-19 | 首都医科大学附属北京同仁医院 | Eyelid force measuring method |
| CN117357060B (en) * | 2023-12-05 | 2024-03-01 | 北京市眼科研究所 | Eyelid pressure measuring device, preparation method and eyelid pressure measuring method |
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| JPH05168599A (en) * | 1991-12-24 | 1993-07-02 | Tatsuo Yamaguchi | Method for measuring eyelid pressure and apparatus therefor |
| JP2008307275A (en) * | 2007-06-15 | 2008-12-25 | Menicon Co Ltd | Sensor for tension of upper and lower eyelids, cover with sheet for tension of upper and lower eyelids, and instrument for quantifying tension of upper and lower eyelids |
| CN103415244A (en) * | 2010-10-20 | 2013-11-27 | 邓迪大学 | Device for monitoring intraocular pressure |
| CN110200586A (en) * | 2019-04-04 | 2019-09-06 | 清华大学 | A kind of intraocular pressure monitoring sensor |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US7137952B2 (en) * | 2001-06-29 | 2006-11-21 | Ecole Polytechnique Federale De Lausanne-Service Des Relations Industrielles | Intraocular pressure recording system |
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| JPH05168599A (en) * | 1991-12-24 | 1993-07-02 | Tatsuo Yamaguchi | Method for measuring eyelid pressure and apparatus therefor |
| JP2008307275A (en) * | 2007-06-15 | 2008-12-25 | Menicon Co Ltd | Sensor for tension of upper and lower eyelids, cover with sheet for tension of upper and lower eyelids, and instrument for quantifying tension of upper and lower eyelids |
| CN103415244A (en) * | 2010-10-20 | 2013-11-27 | 邓迪大学 | Device for monitoring intraocular pressure |
| CN110200586A (en) * | 2019-04-04 | 2019-09-06 | 清华大学 | A kind of intraocular pressure monitoring sensor |
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