CN111956724A - Traditional Chinese medicine preparation for treating diabetes and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for treating diabetes and preparation method thereof Download PDFInfo
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Abstract
The embodiment of the invention discloses a traditional Chinese medicine preparation for treating diabetes, which has quick response and good curative effect, and comprises the following raw materials in parts by weight: 17-23 parts of Chinese yam, 4-6 parts of coptis chinensis, 8-12 parts of red bean, 17-23 parts of discolor cinquefoil herb, 8-12 parts of ginkgo, 4-6 parts of hairyvein agrimony, 4-6 parts of trichosanthes root, 8-12 parts of achyranthes root and 13-17 parts of cornus pulp. The Chinese medicinal preparation can relieve or eliminate hyperglycemia symptoms, repair organism tissues, and normalize organism metabolism function, thereby fundamentally treating diabetes. The embodiment of the invention also provides a preparation method of the traditional Chinese medicine preparation.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine preparation for treating diabetes and a preparation method thereof.
Background
Diabetes is now a group of metabolic diseases characterized by hyperglycemia, and causes symptoms of hyperglycemia in the body for a long time due to defective insulin secretion or impaired biological action or both, which leads to chronic damage and dysfunction of body tissues, particularly eyes, kidneys, heart, blood vessels, nerves.
At present, diabetes is mainly treated by injecting insulin in western medicine, and other hypoglycemic drugs are supplemented. These drugs have a great side effect on the body, cannot restore the body tissues fundamentally, and generally need to be taken for life.
Diabetes belongs to diabetes and splenic fever in traditional Chinese medicine. Diabetes is the disease name of traditional Chinese medicine, and refers to the comprehensive symptoms mainly characterized by polydipsia, diuresis, polyphagia, emaciation, fatigue and urine sweetness. Diabetes, lung heat damaging fluid and thirst with polydipsia as the upper part of the traditional Chinese medicine; the stomach-fire is stir-baked to exuberance, and the food is fully allayed by hunger; kidneys do not control water and frequent urination is descending and dispersing. The syndrome of diabetes can not be caused by lung dryness, stomach heat and kidney deficiency complicated with or with side weight.
The treatment method for the disease mainly comprises clearing heat, moistening lung, promoting fluid production and quenching thirst (upper digestive tract); clearing stomach-heat, nourishing yin and promoting fluid production (middle warmer); nourishing yin and tonifying kidney (descending and dispersing), and some prescriptions have been recorded, but the effect is not very definite.
Disclosure of Invention
The embodiment of the invention aims to provide a traditional Chinese medicine preparation for treating diabetes, which has quick response and good curative effect, can relieve or eliminate hyperglycemia symptoms, can repair body tissues and normalize body metabolism functions, thereby treating diabetes fundamentally. The embodiment of the invention also provides a preparation method of the traditional Chinese medicine preparation.
In order to achieve the above purpose, the embodiment of the present invention provides a traditional Chinese medicine preparation for treating diabetes, which comprises the following raw material components by weight: 17-23 parts of Chinese yam, 4-6 parts of coptis chinensis, 8-12 parts of red bean, 17-23 parts of discolor cinquefoil herb, 8-12 parts of ginkgo, 4-6 parts of hairyvein agrimony, 4-6 parts of trichosanthes root, 8-12 parts of achyranthes root and 13-17 parts of cornus pulp.
Preferably, the traditional Chinese medicine preparation comprises the following raw materials in parts by weight: 18-22 parts of Chinese yam, 4-6 parts of coptis chinensis, 9-11 parts of red bean, 18-22 parts of discolor cinquefoil herb, 9-11 parts of ginkgo, 4-6 parts of hairyvein agrimony, 4-6 parts of trichosanthes root, 9-11 parts of achyranthes root and 14-16 parts of cornus pulp.
In a preferred embodiment, the traditional Chinese medicine preparation comprises the following raw materials in parts by weight: 20 parts of Chinese yam, 5 parts of coptis chinensis, 10 parts of red bean, 20 parts of discolor cinquefoil herb, 10 parts of ginkgo, 5 parts of rootless vine, 5 parts of trichosanthes root, 10 parts of achyranthes root and 15 parts of cornus pulp.
In another preferred embodiment, the Chinese medicinal preparation comprises the following raw material ingredients in parts by weight: 18 parts of Chinese yam, 4 parts of coptis chinensis, 9 parts of red bean, 18 parts of discolor cinquefoil herb, 9 parts of ginkgo, 4 parts of rootless vine, 4 parts of trichosanthes root, 9 parts of achyranthes root and 14 parts of cornus pulp.
In another preferred embodiment, the Chinese medicinal preparation comprises the following raw material ingredients in parts by weight: 22 parts of Chinese yam, 6 parts of coptis chinensis, 11 parts of red bean, 22 parts of discolor cinquefoil herb, 11 parts of ginkgo, 6 parts of rootless vine, 6 parts of trichosanthes root, 11 parts of achyranthes root and 16 parts of cornus pulp.
The inventor thinks that the disease is mainly caused by the comprehensive factors of spleen failure, qi and yin deficiency, liver and kidney deficiency and the like, and selects the 9 Chinese herbal medicines and compounds the Chinese herbal medicines according to a reasonable proportion through dialectical analysis and intensive research of the theory of traditional Chinese medicine to obtain the Chinese herbal preparation for treating diabetes. The preparation can generate a drug effect synergistic effect among the components, and is scientifically compatible according to the monarch, minister, assistant and guide theory, so that the drug effect of each component is maximized, the effect of treating both symptoms and root causes of diabetes is achieved, and hyperglycemia symptoms can be quickly and effectively reduced or eliminated, so that diabetic patients can get rid of dependence on insulin and other drugs.
The traditional Chinese medicine preparation for treating diabetes has the following raw material components:
chinese yam: also called Dioscorea opposita, and Dioscorea alba, which are dried roots and stems of Dioscorea opposita of Dioscoreaceae. Sweet taste, warm and mild nature, and no toxicity. Rhizoma Dioscoreae has effects of nourishing and strengthening body, promoting digestion, astringing asthenic perspiration, and relieving diarrhea, and can be used for treating spleen deficiency diarrhea, lung deficiency cough, diabetes, frequent micturition, nocturnal emission, female leukorrhagia and chronic enteritis due to dyspepsia. Has effects in invigorating qi and spleen.
Coptis chinensis: also called as Weilian, Chuan Lian and Ji Zuo, is the dried rhizome of Coptis chinensis, Coptis deltoidea or Yun Lian of Ranunculaceae. Bitter taste and cold nature. It enters heart, spleen, stomach, liver, gallbladder and large intestine meridians. Has the effects of clearing heat, eliminating dampness, purging pathogenic fire and removing toxic substances. Mainly treats damp-heat fullness, vomiting and acid regurgitation, diarrhea, jaundice, high fever and coma, hyperactivity of heart-fire, vexation and insomnia, palpitation and restlessness, blood heat and hematemesis and epistaxis, conjunctival congestion, toothache, diabetes, carbuncle and swelling and sore; it is used externally to treat eczema, eczema and purulent ear canal.
Red bean: the seeds are mature seeds of leguminous plant semen Phaseoli, which is a half-enwound herbaceous plant semen Phaseoli in one year of leguminosae, and are cultivated all over the country, harvested in summer and autumn when pods are mature, dried in the sun, and collected for later use. Seeds are eaten; when used as a medicine, has the effects of promoting blood circulation, tonifying blood, invigorating spleen, eliminating dampness, inducing diuresis and relieving swelling.
Herba Potentillae Discoloris: also named as Potentilla discolor, agrimony, Chinese forest frog grass, crow's foot, Chinese white wormwood, etc., is the dried whole herb of Potentilla chinensis which is a perennial herb of Rosaceae. Sweet, slightly bitter and neutral in nature. It enters liver and large intestine meridians. Has the effects of clearing away heat and toxic materials, cooling blood and relieving dysentery.
And (3) ginkgo: is dried seed of Ginkgo biloba of Ginkgoaceae. Sweet, bitter and astringent taste, warm and mild nature and slight toxicity. Enter lung and kidney meridians. Astringe lung qi, relieve dyspnea and cough, stop leukorrhagia and reduce urination. It can be used for treating asthma, cough with phlegm, leucorrhea, whitish and turbid urine, spermatorrhea, gonorrhea, and frequent micturition.
Rootless vine: also called Sargentodoxa cuneata, and Hypericum perforatum, etc., are whole herbs of Sargentodoxa cuneata of the genus Sargentodoxa in Lauraceae. Sweet, slightly bitter and cool in nature. Enter liver and kidney meridians. Has the effects of clearing heat, promoting diuresis, cooling blood and stopping bleeding. Can be used for treating common cold, fever, malaria, acute icterohepatitis, hemoptysis, epistaxis, hematuria, urinary calculus, nephritis, and edema; it is used externally to treat eczema, multiple furuncle and swelling.
Trichosanthes root: trichosanthis radix is dry root of Trichosanthes kirilowii Maxim of Cucurbitaceae, and is sweet, slightly bitter and slightly cold. It enters lung and stomach meridians. The specific effects are clearing heat and purging fire, promoting the production of body fluid to quench thirst, and expelling pus and reducing swelling. The main treatment is as follows: thirst due to heat disease, diabetes, jaundice, lung dryness, hemoptysis, carbuncle, swelling, and hemorrhoid flaccidity. For treating diabetes, it is often used in combination with yin-nourishing herbs to achieve the effect of treating both principal and secondary aspect of disease.
Achyranthes root: also called radix achyranthis bidentatae and kou, which are the dried roots of radix achyranthis bidentatae which belongs to perennial herb plants. Bitter, sweet and sour in taste and neutral in nature. It enters liver and kidney meridians. Has effects of removing blood stasis, dredging channels, nourishing liver and kidney, strengthening tendons and bones, inducing diuresis, treating stranguria, and promoting blood circulation. Tonify liver and kidney, strengthen waist and knees; it is indicated for soreness and pain of waist and knees, liver and kidney deficiency, traumatic injury, blood stasis and pain.
Cornus officinalis: it is also called cornus officinalis, yam jujube and chicken feet, etc., and is the dried mature pulp of cornus officinalis of the family of dicotyledonous plants, dogwood. Sour and astringent taste, slightly warm in nature. Enter liver and kidney meridians. Has effects of nourishing liver and kidney, astringing essence and qi, and consolidating deficiency. It is used to treat soreness of waist and knees, vertigo, tinnitus, sexual impotence, spermatorrhea, frequent micturition, liver deficiency, cold and heat, sweating, and heart shaking pulse powder.
Further, the traditional Chinese medicine preparation for treating diabetes of the present invention may be decoction, pill, tablet, granule, paste, syrup, granule, etc. which are generally used for oral administration. Preferably in the form of decoction, pill or granule. For example, the raw material components of the traditional Chinese medicine preparation for treating diabetes can be prepared into decoction according to the weight ratio by adopting a decoction mode and the like for administration. However, from the viewpoint of convenience in carrying and administration, the decoction prepared above can also be further prepared into pills or granules.
Another aspect of the embodiments of the present invention provides a preparation method of the traditional Chinese medicine preparation for treating diabetes, including the following steps:
(1) weighing the raw material components in proportion, cleaning, coarsely crushing and mixing, and soaking in clear water;
(2) adding clear water, decocting for three times, extracting the three decoctions, and mixing to obtain total medicinal liquid;
(3) concentrating the total liquid medicine to obtain the traditional Chinese medicine preparation for treating diabetes.
Further, the step (2) in the above preparation method comprises the steps of:
(21) decocting for the first time, adding water into the soaked medicinal materials until the water amount is 5 times of the weight of the dry medicinal materials, decocting for 1.5 hours, and pouring out the first decoction;
(22) decocting for the second time, adding water into the first decocted medicinal materials to make water amount 3 times of the weight of the dry medicinal materials, decocting for 1 hour, pouring out the second decoction, and mixing with the first decoction;
(23) and (3) decocting for the third time, namely adding water into the medicinal materials decocted for the second time to ensure that the water amount is 1 time of the weight of the dry medicinal materials, decocting for 1 hour, pouring out the decoction of the third time, and combining the decoction of the third time with the decoction of the previous two times to obtain the total liquid medicine.
Further, the water amount soaked in the clear water in the step (1) is 2-3 times of the weight of the dry medicinal materials; in the step (3), the total liquid medicine is concentrated to 0.2 to 0.4 time, preferably 0.3 time of the weight of the dry medicine.
Further, the traditional Chinese medicine preparation is a pill, and the preparation method further comprises the following steps:
(41) and (3) taking the raw material components with the same weight and proportion in the step (1), cleaning, crushing, sieving with a 100-mesh sieve, mixing with the concentrated total medicinal liquid in the step (3), and preparing pills.
In a preferred embodiment, the pellet size is 10g per pellet.
Further, the traditional Chinese medicine preparation is electuary, and the preparation method further comprises the following steps:
(42) and (4) uniformly mixing the concentrated total liquid medicine in the step (3) with auxiliary materials, and then drying to obtain granular or powdery granules.
Further, the auxiliary materials comprise dextrin and citric acid.
In a preferred embodiment, the dextrin and the citric acid are added in an amount of 0.1 to 0.3 wt% of the concentrated total medical solution, respectively.
In a preferred embodiment, the drying is vacuum spray drying, preferably low temperature spray drying in vacuum, the drying temperature being from 25 ℃ to 80 ℃.
In a preferred embodiment, the size of the granule is 6g per dose.
In another aspect of the embodiments of the present invention, a method for using the traditional Chinese medicine preparation for treating diabetes is further provided, and the method for using includes:
for pills, the medicine is taken three times a day, 10g each time; for example, warm water;
for the granule, the granule is taken three times a day, 6g each time; for example, it is taken with boiled water.
The dosage and frequency of the above medicines can be increased or decreased according to symptoms. The traditional Chinese medicine composition is used by more than four hundred patients in two years by the inventor, has quick response, no side effect and low medication cost, and can greatly reduce the treatment cost of the patients.
The embodiment of the invention has the following advantages:
1. the traditional Chinese medicine preparation for treating diabetes is prepared by compounding the 9 Chinese herbal medicines according to a reasonable proportion, so that the components can generate a drug effect synergistic effect, and the drug effects of the components are maximized according to the scientific compatibility of the monarch, minister, assistant and guide theory, so that the traditional Chinese medicine preparation achieves the effect of treating both symptoms and root causes of diabetes, can quickly and effectively reduce or eliminate hyperglycemia symptoms, and enables a diabetic patient to get rid of the dependence on drugs such as insulin.
2. The traditional Chinese medicine preparation for treating diabetes mellitus has good taste, is convenient to carry and take, and is easy to be accepted by people, so that the compliance of the people who insist on taking according to the amount on time is improved, and the treatment effect is improved.
3. The traditional Chinese medicine preparation for treating diabetes is easy to carry out industrial production, has low cost and can greatly reduce the treatment cost of patients.
Detailed Description
The present invention is described in terms of particular embodiments, other advantages and features of the invention will become apparent to those skilled in the art from the following disclosure, and it is to be understood that the described embodiments are merely exemplary of the invention and that it is not intended to limit the invention to the particular embodiments disclosed. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
The traditional Chinese medicine preparation for treating diabetes in the embodiment comprises the following raw material components in parts by weight: 200g of Chinese yam, 50g of coptis chinensis, 100g of red bean, 200g of discolor cinquefoil herb, 100g of ginkgo, 50g of rootless vine, 50g of trichosanthes root, 100g of achyranthes and cyathula root and 150g of cornus fruit.
The preparation method comprises the following steps:
(1) weighing the raw material components according to weight, cleaning, coarsely crushing and mixing, and soaking in 2 times of clear water;
(2) decocting with clear water for three times, extracting the decoctions for three times, and mixing to obtain total medicinal liquid, which comprises:
(21) decocting for the first time, adding water into the soaked medicinal materials until the water amount is 5 times of the weight of the dry medicinal materials, decocting for 1.5 hours, and pouring out the first decoction;
(22) decocting for the second time, adding water into the first decocted medicinal materials to make water amount 3 times of the weight of the dry medicinal materials, decocting for 1 hour, pouring out the second decoction, and mixing with the first decoction;
(23) decocting for the third time, adding water to the medicinal materials decocted for the second time to make the water amount 1 time of the weight of the dry medicinal materials, decocting for 1 hour, pouring out the decoction of the third time, and mixing with the decoctions of the previous two times to obtain total liquid medicine;
(3) concentrating the total medicinal liquid to three-tenth of the weight of the dry medicinal materials to obtain the decoction for treating diabetes.
Example 2
The traditional Chinese medicine preparation for treating diabetes in the embodiment comprises the following raw material components in parts by weight: 180g of Chinese yam, 40g of coptis chinensis, 90g of red bean, 180g of discolor cinquefoil herb, 90g of ginkgo, 40g of rootless vine, 40g of trichosanthes root, 90g of achyranthes bidentata and 140g of cornus pulp.
The preparation method is based on the preparation method of the embodiment 1, and comprises the following steps of (1) except that the weight of the raw material components in the step (1) is the weight listed in the embodiment 2:
(41) taking the raw material components with the same weight in the step (1), cleaning, crushing, sieving with a 100-mesh sieve, mixing with the concentrated total medicinal liquid in the step (3), and making into pills with the specification of 10g per pill.
Example 3
The traditional Chinese medicine preparation for treating diabetes in the embodiment comprises the following raw material components in parts by weight: 220g of Chinese yam, 60g of coptis chinensis, 110g of red beans, 220g of discolor cinquefoil herb, 110g of ginkgo, 60g of rootless vine, 60g of trichosanthes root, 110g of achyranthes bidentata and 160g of cornus pulp.
The preparation method is based on the preparation method of the example 1, and comprises the following steps of (1) except that the weight of the raw material components in the step (1) is the weight listed in the example 3:
(42) and (4) uniformly mixing the concentrated total liquid medicine in the step (3) with dextrin and citric acid, wherein the addition amount of the dextrin and the citric acid is 0.2 wt% of the concentrated total liquid medicine respectively. Then spray-drying at low temperature in vacuum to obtain granule with the specification of 6g per dose.
Example 4
The traditional Chinese medicine preparation for treating diabetes in the embodiment comprises the following raw material components in parts by weight: 170g of Chinese yam, 40g of coptis chinensis, 80g of red bean, 170g of discolor cinquefoil herb, 80g of ginkgo, 40g of rootless vine, 40g of trichosanthes root, 80g of achyranthes bidentata and 130g of cornus pulp.
The preparation method was the same as that of example 1 except that the weight of the raw material components in step (1) was the weight as listed in example 4.
Example 5
The traditional Chinese medicine preparation for treating diabetes in the embodiment comprises the following raw material components in parts by weight: 230g of Chinese yam, 60g of coptis chinensis, 120g of red bean, 230g of discolor cinquefoil herb, 120g of ginkgo seed, 60g of rootless vine, 60g of trichosanthes root, 120g of achyranthes root and 170g of cornus pulp.
The preparation method was the same as that of example 1 except that the weight of the raw material components in step (1) was the weight as listed in example 5.
The results of clinical trials of the Chinese medicinal preparation of the present invention for treating diabetes are as follows.
1. Subject of clinical observation
The diabetic patients: 234 cases were observed, of which 161 men and 73 women were all adults; and wherein type 1 diabetes 121 is a person and type 2 diabetes 113 is a person.
2. Method of treatment
All diabetic patients were randomly and evenly divided into three groups of 78 persons each; the first group takes the decoction of example 1 three times a day, 50ml each time; the second group took the pill of example 2 three times a day at 10g each time; the third group took the infusion of example 3 three times a day, 6g each time. One month is taken continuously as a treatment course, and 6 treatment courses are observed at most. During the treatment period, meat and greasy food are not eaten, sugar intake is controlled, and wine is prohibited.
And (4) effect judgment: the clinical diabetes symptom is completely eliminated, and the patients who do not relapse after the follow-up visit for 3 months are healed; the medicine can eliminate more than 45% of symptoms, and is effective for patients who relapse but are lighter than the former patients after 3 months of follow-up visit; others are not.
3. Therapeutic results
103 cases are cured, accounting for 44%; 131 effective cases account for 56%; and invalid 0 case.
The clinical test results show that the traditional Chinese medicine preparation has quick response and good curative effect on the treatment of the diabetes, not only can relieve or eliminate the symptoms of hyperglycemia, but also can repair body tissues and normalize the metabolic function of the body, thereby fundamentally treating the diabetes.
Although the invention has been described in detail above with reference to a general description and specific examples, it will be apparent to one skilled in the art that modifications or improvements may be made thereto based on the invention. Accordingly, such modifications and improvements are intended to be within the scope of the invention as claimed.
Claims (10)
1. The traditional Chinese medicine preparation for treating diabetes is characterized by comprising the following raw materials in parts by weight: 17-23 parts of Chinese yam, 4-6 parts of coptis chinensis, 8-12 parts of red bean, 17-23 parts of discolor cinquefoil herb, 8-12 parts of ginkgo, 4-6 parts of hairyvein agrimony, 4-6 parts of trichosanthes root, 8-12 parts of achyranthes root and 13-17 parts of cornus pulp.
2. The traditional Chinese medicine preparation for treating diabetes according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 18-22 parts of Chinese yam, 4-6 parts of coptis chinensis, 9-11 parts of red bean, 18-22 parts of discolor cinquefoil herb, 9-11 parts of ginkgo, 4-6 parts of hairyvein agrimony, 4-6 parts of trichosanthes root, 9-11 parts of achyranthes root and 14-16 parts of cornus pulp.
3. The traditional Chinese medicine preparation for treating diabetes according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 20 parts of Chinese yam, 5 parts of coptis chinensis, 10 parts of red bean, 20 parts of discolor cinquefoil herb, 10 parts of ginkgo, 5 parts of rootless vine, 5 parts of trichosanthes root, 10 parts of achyranthes root and 15 parts of cornus pulp.
4. The traditional Chinese medicine preparation for treating diabetes according to any one of claims 1 to 3, wherein the traditional Chinese medicine preparation is decoction, pill or granule.
5. The method for preparing a Chinese medicinal preparation for treating diabetes according to any one of claims 1 to 3, wherein the method comprises the following steps:
(1) weighing the raw material components in proportion, cleaning, coarsely crushing and mixing, and soaking in clear water;
(2) adding clear water, decocting for three times, extracting the three decoctions, and mixing to obtain total medicinal liquid;
(3) concentrating the total liquid medicine to obtain the traditional Chinese medicine preparation for treating diabetes.
6. The method for preparing a Chinese medicinal preparation for treating diabetes according to claim 5, wherein the step (2) comprises the following steps:
(21) decocting for the first time, adding water into the soaked medicinal materials until the water amount is 5 times of the weight of the dry medicinal materials, decocting for 1.5 hours, and pouring out the first decoction;
(22) decocting for the second time, adding water into the first decocted medicinal materials to make water amount 3 times of the weight of the dry medicinal materials, decocting for 1 hour, pouring out the second decoction, and mixing with the first decoction;
(23) and (3) decocting for the third time, namely adding water into the medicinal materials decocted for the second time to ensure that the water amount is 1 time of the weight of the dry medicinal materials, decocting for 1 hour, pouring out the decoction of the third time, and combining the decoction of the third time with the decoction of the previous two times to obtain the total liquid medicine.
7. The method for preparing a Chinese medicinal preparation for treating diabetes according to claim 6, wherein the amount of water soaked in clear water in step (1) is 2-3 times of the weight of the dry medicinal materials; in the step (3), the total liquid medicine is concentrated to 0.2 to 0.4 time of the weight of the dry medicine.
8. The method for preparing a Chinese medicinal preparation for treating diabetes according to claim 7, wherein the Chinese medicinal preparation is a pill, and the method further comprises the following steps:
(41) and (3) taking the raw material components with the same weight and proportion in the step (1), cleaning, crushing, sieving with a 100-mesh sieve, mixing with the concentrated total medicinal liquid in the step (3), and preparing pills.
9. The method for preparing a Chinese medicinal preparation for treating diabetes according to claim 7, wherein the Chinese medicinal preparation is a granule, and the method further comprises the following steps:
(42) and (4) uniformly mixing the concentrated total liquid medicine in the step (3) with auxiliary materials, and then drying to obtain granular or powdery granules.
10. The method for preparing a Chinese medicinal preparation for treating diabetes according to claim 9, wherein the adjuvant comprises dextrin and citric acid, and the addition amounts thereof are 0.1-0.3 wt% of the concentrated total liquid medicine, respectively.
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CN106728678A (en) * | 2016-12-27 | 2017-05-31 | 上海天韶科技发展有限公司 | The herbal mixture and preparation method of hypoglycemic |
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