CN111956539A - Anti-allergy soothing and skin barrier repairing essence cream - Google Patents

Abstract

The invention discloses an anti-allergy, soothing and skin barrier repair essence cream which comprises 5-8% of a natural skin conditioner, 0.5-1% of an anti-allergy agent, 10-15% of a humectant, auxiliary materials and the balance; the natural skin conditioner comprises shea butter, camellia extract, camellia oil and centella extract in a specific ratio, and the anti-allergy agent comprises dipotassium glycyrrhizinate and pseudoanise leaf extract in a specific ratio. The condensed multiple natural plant essence is used as a skin conditioner, has a light formula, is mild and moist, and is suitable for sensitive muscles; and the synergistic powerful anti-allergy agent can efficiently repair damaged skin and barriers, improve inflammation such as skin dryness and itching, allergic red blood streak and the like, form multiple protective barriers, improve the skin resistance, improve the skin tolerance, reduce the skin sensitivity, relieve the repair for a long time and stabilize the skin condition.

Description

Anti-allergy soothing and skin barrier repairing essence cream

Technical Field

The invention relates to the technical field of cosmetics, and particularly relates to an anti-allergy soothing and skin barrier repairing essence cream.

Background

A healthy skin barrier can lock up skin moisture and block external irritation. But along with the acceleration of life and work rhythm, the skin of people who love beauty is challenged by various factors such as stress, staying up all night, sedentary, long-time computer facing, endocrine disturbance and the like; the skin is accelerated to age due to external factors such as sunlight, artificial light irradiation, air pollution, ionizing radiation, dust, particles and chemicals in the environment, the skin is damaged, the skin barrier is damaged, the moisture of the skin is easy to lose, external stimulation is easy to deeply damage the skin, the external stimulation cannot be resisted, and fragile sensitive muscles are formed.

Sensitive skin is fragile and poor in resistance, symptoms such as red blood streak, edema and telangiectasia are easy to appear after external stimulation is applied, and skin is easy to feel itching, stabbing pain, burning heat, tightness and the like. The skin is particularly easy to have the conditions of season-changing dry itch, sensitive makeup and makeup removal, sunburn, stabbing pain, burning, reddening and acne, medium-intensity exercise, mood fluctuation, skin vasodilatation, hyperemia, redness and the like, and influences the daily life and work. The skin care product for sensitive skin has high requirements, the existing anti-sensitive skin care product has unobvious red-removing, swelling-reducing and anti-inflammatory effects on the premise of moisture retention and hyposensitivity, the skin still needs to be repaired by self, the health is recovered, the time is long, the inconvenience is brought to daily work and life, acne marks and the like are easy to generate, and the skin quality is affected.

Disclosure of Invention

In order to overcome the defects of the prior art, the invention aims to provide the anti-allergy, comfort and skin barrier repair essence cream, which is light in formula, mild and moist and suitable for sensitive muscles, and multiple natural plant essences are condensed to be used as a skin conditioner; and the synergistic powerful anti-allergy agent can efficiently repair damaged skin and barriers, improve inflammation such as skin dryness and itching, allergic red blood streak and the like, form multiple protective barriers, improve the skin resistance, improve the skin tolerance, reduce the skin sensitivity, relieve the repair for a long time and stabilize the skin condition.

The purpose of the invention is realized by adopting the following technical scheme:

an anti-allergy, comfortable and mild skin barrier repair essence cream comprises the following components in percentage by weight: 5-8% of natural skin conditioner; 0.5-1% of anti-allergic agent; 10-15% of a humectant; auxiliary materials and the balance;

the natural skin conditioner comprises, by weight, 2-5 parts of shea butter, 1-3 parts of camellia extract, 0.5-1.5 parts of camellia seed oil and 0.3-0.8 part of centella asiatica extract;

the anti-allergy agent comprises 1-3 parts of dipotassium glycyrrhizinate and 3-8 parts of pseudoanise leaf extract according to parts by weight.

Further, the humectant is one or any combination of trehalose, saccharide isomerate, lecithin, betaine, sodium hyaluronate and polyhydric alcohol.

Preferably, the polyol is a combination of 1, 3-propanediol, polyglycerol-10, glycerol and 1, 2-hexanediol.

Further, the auxiliary materials comprise a softening agent, an antioxidant, an emulsifier, a film forming agent and an aroma regulator.

Preferably, the emollient is one or any combination of ethylhexyl palmitate, neopentyl glycol diheptanoate, cetearyl alcohol, bis-behenyl alcohol/isostearyl alcohol/phytosterol dioleyl alcohol dilinoleate, and polydimethylsiloxane.

The antioxidant comprises tocopherol acetate.

The emulsifier is one or any combination of cetearyl glucoside, glyceryl stearate, PEG-100 stearate and glyceryl caprylate.

The film forming agent is acrylate copolymer sodium;

the aromatic regulator comprises cananga oil and bitter orange leaf oil.

Further, the anti-allergy, comfort and skin barrier repair essence cream comprises the following components in percentage by weight:

5-8% of natural skin conditioner; 0.5-1% of anti-allergic agent; 10-15% of a humectant; 10-15% of softening agent; 0.3-1% of antioxidant; 1-3% of emulsifier; 0.01 to 0.05 percent of film-forming agent; 0.01 to 0.06 percent of aromatic regulator; water and the balance.

Compared with the prior art, the invention has the beneficial effects that:

1. the essence cream provided by the invention has the effects of resisting allergy and removing redness. The pseudoanise leaf extract is taken as a core, so that the expression of a proinflammatory factor COX-2 (COX-2 is an inducible enzyme and can cause inflammatory reaction and tissue damage) is effectively reduced; and the dipotassium glycyrrhizinate is added, so that the expression of atopic dermatitis related genes can be reduced, and the release of related factors can be reduced. The pseudoanise leaf extract and dipotassium glycyrrhizinate have synergistic effect, so that inflammation symptoms can be eliminated effectively, and skin irritation can be relieved immediately; and natural components such as camellia extract and the like are added for rapidly repairing wounds, promoting the formation of collagen, resisting inflammation and repairing from inside to outside, rapidly removing red, eliminating inflammation, forming a skin protection barrier, and maintaining the stability of the skin for a long time.

2. The essence cream has the effect of strongly resisting external pollution. By adding the camellia seed oil and the camellia extract, a protective net for isolating free radicals is built on the surface of the skin, so that the invasion of environmental pollution is effectively resisted, the damage of isolated ultraviolet rays to the skin can be blocked, external radiation is resisted, and a stimulus source which brings sensitivity and damage to the skin is isolated from the surface layer of the skin; meanwhile, the skin color can be compacted and brightened.

3. The essence cream disclosed by the invention has the effects of deeply supplementing water and repairing skin water barriers. The saccharide isomerate cooperates with the centella asiatica extract and the shea butter, deeply moisturizes and locks water, resists allergy and repairs, can strengthen and strengthen the skin barrier, establishes the skin shield, can improve the density of the dermis and promotes the formation of collagen. The trehalose, the sodium hyaluronate and the betaine are added, so that the skin cream is easy to absorb, other components are guided into the skin, and the stability of active substances such as polyphenol can be kept, so that the essence cream can keep stable activity for a long time.

4. The essence cream disclosed by the invention is prepared by condensing multiple natural plants, is light in formula, mild and moist, and is not greasy; the damaged skin is repaired effectively, the inflammation such as dry and itchy skin, allergic red blood streak and the like is improved, multiple protective barriers are formed, and the skin resistance is improved; brings soothing, repairing, constant moistening, nourishing and vitality for skin, can improve the tolerance of the skin, stabilize the skin condition and reduce the sensitivity, and is suitable for sensitive muscles and the like.

Drawings

FIG. 1 shows the results of Experimental example 1

An analytical graph of the camellia extract promoting collagen synthesis;

FIG. 2 is a graph of the effect of the serum of example 2 on the inhibition of VEGF production in HaCaT cells;

fig. 3 is a line graph showing the moisture retention performance test of the essence creams of examples 1 to 5.

Detailed Description

The present invention will be further described with reference to the accompanying drawings and the detailed description, and it should be noted that any combination of the embodiments or technical features described below can be used to form a new embodiment without conflict.

An anti-allergy, comfortable and mild skin barrier repair essence cream comprises the following components in percentage by weight: 5-8% of natural skin conditioner; 0.5-1% of anti-allergic agent; 10-15% of a humectant; auxiliary materials and the balance;

wherein the natural skin conditioner comprises 2 to 5 portions of shea butter, 1 to 3 portions of camellia extract, 0.5 to 1.5 portions of camellia seed oil and 0.3 to 0.8 portion of centella asiatica extract according to the weight portion;

the camellia extract contains excellent soothing and antiallergic active ingredients, can build a protective net for isolating free radicals, can effectively resist the invasion of environmental pollution, and has remarkable effects on symptoms of allergy, edema, erythema and the like brought by the environment and small side effects. The camellia extract camellia contains abundant flavone, saponin, catechin, vitamin C, tannic acid, amino acid and other components, has excellent antioxidant and anti-free radical effects, contains moisturizing and anti-allergy activities, can effectively prevent skin melanin from precipitating, prevents series of skin problems caused by environmental pollution of the skin, and maintains the health and freshness of the skin. The effects of improving skin barrier, moisturizing, lightening spots, tightening and brightening skin color are achieved.

Preferred uses of the invention

The camellia extract is found by a large number of experiments in the prior period,

the camellia extract can promote the expression of skin collagen and dermal-epidermal junction protein, effectively protect the skin from being damaged by environmental pollution, and block ultraviolet rays and fine particles; in the collagen ELISA assay and in vitro experiments,

the camellia extract showed a significant effect of increasing collagen synthesis.

The camellia seed oil has excellent isolation and antioxidant effects, can protect antioxidant enzymes in vivo and can promote and activate the activity of the antioxidant enzymes in vivo, such as SOD, CAT and GSH-PX. The camellia seed oil can also complex excessive free iron, so that the damage of free radicals is reduced; the copper complex has weak complexation, can inhibit the oxidation of low-density lipoprotein (LDL) catalyzed by copper, and can not influence the SOD activity taking the copper as the center; complexing intracellular calcium inhibits xanthine oxidase production. The camellia oil and the camellia extract are cooperated to establish a protective layer for isolating sun-screening and resisting radiation, and a skin barrier is repaired. The camellia seed oil also has excellent skin conditioning effect, good skin compatibility, easy absorption by human body, oxidation resistance, speckle reduction, moisture retention, skin moistening and fine wrinkle removal.

The shea butter fruit resin has obvious moisturizing and water replenishing effects, is easy to absorb, enhances the skin moisturizing capability, can effectively prevent the skin moisture loss, and assists in establishing a skin water barrier; can also help wound healing, synergistically repair skin injury and increase the defense capacity of skin. The shea butter is used as natural butter, simulates the composition of nascent fetal fat, is safe and mild, and can help the skin to perfectly blend water and oil.

Centella asiatica extract has many active ingredients and has good skin caring and repairing effects. The herba Centellae extract can promote wound cell proliferation and collagen synthesis, promote wound epithelial tissue generation, and promote wound healing. The asiatic pennywort herb extract has excellent effects of relieving irritation, repairing skin and the like, can help damaged skin tissues to repair, calm skin, relieve sensitivity, prevent skin from drying, redness and desquamation, improve dark and uneven skin color and increase the resistance of skin.

The anti-allergy agent comprises 1-3 parts of dipotassium glycyrrhizinate and 3-8 parts of illicium simonsii leaf extract by weight.

The illicium simonii leaf extract contains multifunctional natural active ingredients, can inhibit the release of proinflammatory factors, immediately relieve skin irritation, relieve skin discomfort and reduce clinical symptoms related to skin pruritus and redness; the traditional Chinese medicine composition has a synergistic effect with other components with repair effects, quickly eliminates inflammation and allergic symptoms, and has remarkable red-dispelling and swelling-reducing effects.

The humectant is one or any combination of trehalose, saccharide isomer, lecithin, betaine, sodium hyaluronate and polyalcohol. Wherein the polyalcohol is the combination of 1, 3-propylene glycol, polyglycerol-10, glycerol and 1, 2-hexanediol.

The saccharide isomerate is a natural humectant extracted from a natural plant saccharide complex, is similar to a carbohydrate complex in a human body, has good skin-friendly performance, can immediately provide a deep moisturizing effect, and recovers a skin moisturizing barrier. Can be combined with free amino acid groups of lysine on keratin in cells of the horny layer to assist the keratin of the horny layer to combine with water, and has long moisturizing effect because the keratin cannot be easily washed off.

The adjuvants include emollient, antioxidant, emulsifier, film-forming agent, and aromatic regulator.

Wherein the emollient is one or any combination of ethylhexyl palmitate, neopentyl glycol diheptanoate, cetostearyl alcohol, bis-behenyl alcohol/isostearyl alcohol/phytosterol dioleyl alcohol dilinoleate, and polydimethylsiloxane.

Antioxidants include tocopheryl acetate. The weak bacteriostatic ability of the polyol system and the antioxidant in the humectant disclosed by the invention is combined, so that a natural preservative system can be formed.

The emulsifier is one or any combination of cetearyl glucoside, glyceryl stearate, PEG-100 stearate, and glyceryl caprylate.

The film forming agent is acrylate copolymer sodium;

the aroma regulator comprises cananga oil and bitter orange leaf oil.

As a further preferable scheme, the anti-allergy soothing and skin barrier repair essence cream comprises the following components in percentage by weight:

5-8% of natural skin conditioner; 0.5-1% of anti-allergic agent; 10-15% of a humectant; 10-15% of softening agent; 0.3-1% of antioxidant; 1-3% of emulsifier; 0.01 to 0.05 percent of film-forming agent; 0.01 to 0.06 percent of aromatic regulator; water and the balance.

Experimental example 1

The camellia extract is used for promoting collagen synthesis experiment:

the camellia extract used in this experimental example was

Camellia extract.

The pig skin dermal model was used for the test of stimulating collagen production. After the pigskin is cut, TGF-beta 20ng/ml and the invention thereof are respectively coated

Camellia extract 10ppm, the invention

The camellia extract is 50ppm, a blank control group is set and is not coated with any product, and the camellia extract is cultured for 6 days; each group was subjected to repeated experiments using 4 pieces of skin. After 6 days, collagen content was measured using image software after treatment with Miller staining technique, and the results are shown in fig. 1.

As can be seen from FIG. 1, the invention

The camellia extract has obvious effect of increasing the synthesis of collagen.

Examples 1 to 5

An anti-allergy, comfortable and mild skin barrier repair essence cream comprises the following components in percentage by weight:

the natural skin conditioner, the anti-allergy agent, the humectant, the emollient, the emulsifier, the film forming agent and the fragrance regulator comprise the following specific components shown in the following table 1, and the balance of water in the table.

Table 1 formula of anti-allergy soothing and skin barrier repair essence creams of examples 1-5

The anti-allergy soothing and skin barrier repair essence creams of examples 1 to 5 were prepared according to the following method:

respectively preparing water phase mixed liquor and oil phase mixed liquor according to the formula in the table 1; then pouring the water phase mixed solution into the oil phase mixed solution at the temperature of 80 ℃, homogenizing at a high speed and stirring uniformly; cooling to 50 deg.C, adding aromatic regulator, stirring, and standing to room temperature.

Effect evaluation and Performance detection

(1) Detection of efficacy of removing redness

1) The essence cream (camellia cream) of example 2 is dissolved in DMSO to prepare a mother solution with a concentration of 1g/ml for later use.

2) Spreading human immortalized keratinocyte (HaCaT cell) in good growth state on a culture dish, culturing for 24H for adherence, replacing culture medium containing 125 μ g/ml essence cream (camellia cream) of example 2, and adding H₂O₂Inducing the generation of Vascular Endothelial Growth Factor (VEGF), and continuing to culture for 24 h. Removing cell culture supernatant, centrifuging and taking supernatant for ELISA detection to obtain the influence of the camellia cream of example 2 on the VEGF content.

3) The preparation method is characterized in that the essence cream (camellia cream) of example 2 is not added, and H is not added₂O₂As a blank group; the method is characterized in that the essence cream (camellia cream) in the example 2 is not added, and the same amount of H is added₂O₂The test of (3) was used as a control group to detect the corresponding VEGF content.

The results are shown in FIG. 2, where, # # denotes: p is less than 0.05 compared with the blank group; denotes: p < 0.01 compared to control.

As can be seen from fig. 2, compared with the control group, the essence cream of the present invention can significantly inhibit the VEGF content in HaCaT cells (about 60% of the control group), indicating that the essence cream of the present invention has significant inhibitory effect on the VEGF production in HaCaT cells, and has strong red blood removing effect. The detection example is obtained by detection of Guangdong and big gene medicine engineering research center, Inc., of the national engineering research center of gene engineering medicines.

(2) Water replenishment performance detection

The essence creams of examples 1-5 were used for human body tests, using

The dual MPA580 skin tester detects, specifically is the operation:

randomly selecting a plurality of volunteers with healthy skin and no skin diseases or allergic history, and selecting the proper area of the inner upper arm area of the volunteers as a test area. Before testing, volunteers were allowed to calm down at room temperature in an environment of 50. + -.2% relative humidity, and the test area was cleaned with a cleaning product, wiped evenly with alcohol and then allowed to air dry. The test area is divided into 4 blocks (each block takes 3cm multiplied by 3cm), 5 points are taken for each block to carry out measurement, and the average value is taken as the data result of the test area. The skin moisture retention value was measured before application of the product to obtain a blank control value. Then 2 drops of the product to be tested were applied to each test area, gently tapped until absorption, and then the skin moisturizing values of the test area immediately, 5 hours and 10 hours were measured with a skin tester, respectively, and the moisturizing effect was evaluated, with the results shown in table 3 and fig. 3.

TABLE 3 moisture retention test results recording sheet

As can be seen from the data in Table 3 and the data in FIG. 3, the essence cream of the present invention has good moisturizing performance, can repair the skin water barrier, and can reduce water loss. Comparing examples 1-3, it can be seen that the moisturizing performance is increased in a dose-dependent manner by saccharide isomers; compared with the examples 2 and 4, the saccharide isomer can be added to be synergistic with other components, so that the water replenishing and moisturizing performance of the essence cream is obviously improved; it can also be seen from comparative examples 2 and 5 that the addition of the pseudoanise leaf extract synergistically increases the moisturizing properties of the saccharide isomers.

The above embodiments are only preferred embodiments of the present invention, and the scope of the present invention is not limited thereto, and any insubstantial changes and substitutions made by those skilled in the art based on the present invention are within the scope of the present invention claimed in the present invention.

Claims (10)

1. The anti-allergy, comfortable and mild skin barrier repair essence cream is characterized by comprising the following components in percentage by weight: 5-8% of natural skin conditioner; 0.5-1% of anti-allergic agent; 10-15% of a humectant; auxiliary materials and the balance;

the natural skin conditioner comprises, by weight, 2-5 parts of shea butter, 1-3 parts of camellia extract, 0.5-1.5 parts of camellia seed oil and 0.3-0.8 part of centella asiatica extract;

the anti-allergy agent comprises 1-3 parts of dipotassium glycyrrhizinate and 3-8 parts of pseudoanise leaf extract according to parts by weight.

2. The anti-allergy, soothing and skin barrier repair essence cream according to claim 1, wherein the moisturizer is one or any combination of trehalose, saccharide isomers, lecithin, betaine, sodium hyaluronate, and polyhydric alcohol.

3. The anti-allergy soothing and skin barrier repair essence cream according to claim 2, wherein the polyhydric alcohol is a combination of 1, 3-propanediol, polyglycerol-10, glycerol and 1, 2-hexanediol.

4. The anti-allergy, soothing and skin barrier repair essence cream according to claim 1, wherein the auxiliary materials comprise an emollient, an antioxidant, an emulsifier, a film-forming agent and an aroma regulator.

5. The anti-allergy, soothing and skin barrier repair essence cream according to claim 4, wherein the emollient is one or any combination of ethylhexyl palmitate, neopentyl glycol diheptanoate, cetearyl alcohol, bis-behenyl alcohol/isostearyl alcohol/phytosterol dioleyl alcohol dilinoleate, and polydimethylsiloxane.

6. The anti-allergy soothing and skin barrier repair serum according to claim 4, wherein the antioxidant comprises tocopheryl acetate.

7. The anti-allergy soothing and skin barrier repair cream as claimed in claim 4, wherein the emulsifier is one or any combination of cetearyl glucoside, glyceryl stearate, PEG-100 stearate, glyceryl caprylate.

8. The anti-allergy, soothing and skin barrier repair essence cream according to claim 4, wherein the film-forming agent is sodium acrylate copolymer.

9. The anti-allergy soothing and skin barrier repair essence cream according to claim 4, wherein the fragrance modulator comprises cananga oil, neroli oil.

10. The anti-allergy soothing and skin barrier repair essence cream according to any one of claims 4 to 9, comprising the following components in weight percent:

5-8% of natural skin conditioner; 0.5-1% of anti-allergic agent; 10-15% of a humectant; 10-15% of softening agent; 0.3-1% of antioxidant; 1-3% of emulsifier; 0.01 to 0.05 percent of film-forming agent; 0.01 to 0.06 percent of aromatic regulator; water and the balance.

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