CN111956513A

CN111956513A - Sunscreen lotion and preparation method thereof

Info

Publication number: CN111956513A
Application number: CN202010953550.0A
Authority: CN
Inventors: 方锦寿
Original assignee: Guangzhou Qianzhi Herbal Cosmetics Co ltd
Current assignee: Guangzhou Qianzhi Herbal Cosmetics Co ltd
Priority date: 2020-09-11
Filing date: 2020-09-11
Publication date: 2020-11-20

Abstract

The application relates to a sunscreen emulsion and a preparation method thereof, wherein the sunscreen emulsion comprises the following components: a broad spectrum sunscreen agent; diethylhexyl butamido triazone; phenylbenzimidazole sulfonic acid; a phenyl salicylate emulsifier; a pH adjusting agent; deionized water; also relates to a preparation method of the sunscreen emulsion, which comprises the following steps: step 1-1, mixing titanium dioxide, ethylhexyl triazone, diethyl hexyl butamido triazone, phenyl salicylate and an emulsifier to obtain a first mixture; step 1-2, mixing a pH regulator and phenylbenzimidazole sulfonic acid to obtain a second mixture; step 1-3, mixing deionized water and methylene bis-benzimidazolyl tetramethyl butyl phenol to obtain a third mixture; step 2, mixing the first mixture and the second mixture to obtain a fourth mixture; and 3, mixing the fourth mixture and the third mixture to obtain the sun-screen emulsion. This application has the effect that sun-proof intensity is high.

Description

Sunscreen lotion and preparation method thereof

Technical Field

The application relates to the field of cosmetics, in particular to sun block.

Background

In recent years, with the acceleration of the industrialization process, the intensity of ultraviolet rays reaching the earth surface in sunlight is getting larger, ultraviolet rays influencing human bodies are divided into UVA rays and UVB rays, the wavelength range of the UVA rays is 320-400 nm, premature aging is caused, the wavelength range of the UVB rays is 275-320 nm, and UVB rays can burn skin, sunburn, skin discoloration and redness.

The existing sunscreen products are compounded by a plurality of sunscreens, the wavelength of UVB rays is smaller than that of UVA rays, and the UVB rays carry higher and stronger energy than the UVA rays, so that the damage of the UVB rays to skin is most direct and serious, the sunscreen intensity of the UVB sunscreens in the sunscreen products is high, various sunscreens with different absorption intensities are usually added to enable the absorption intensity of the sunscreen products to be higher, the existing sunscreen products mainly comprise two types of oily sunscreens and aqueous sunscreens, and the oily sunscreens are usually higher than the absorption intensity of the aqueous sunscreens, so most of the sunscreen products are oily.

At present, in order to meet the requirements of consumers on skin feeling, sunscreen products in the market usually adopt a formula of mixing aqueous sunscreen agents and oily sunscreen agents, the dosage of the oily sunscreen agents is reduced by adding the aqueous sunscreen agents, and fresh skin feeling is achieved.

Disclosure of Invention

In view of the disadvantages of the prior art, it is an object of the present application to provide a sunscreen lotion having a high effect of absorbing ultraviolet rays.

In view of the defects of the prior art, the second purpose of the present application is to provide a preparation method of sunscreen lotion, which has the effect of uniformly mixing all the sunscreen agents.

The above object of the present invention is achieved by the following technical solutions:

8-10 parts of a broad-spectrum sunscreen agent;

5-7.5 parts of diethyl hexyl butamido triazone;

2-4 parts of phenylbenzimidazole sulfonic acid;

0.5-0.7 part of phenyl salicylate;

1.5-2.5 parts of an emulsifier;

0.3-0.5 part of pH regulator;

45-55 parts of deionized water.

By adopting the technical scheme, the diethylhexyl butamido triazone is added and is an oil-soluble sun-screening agent, a protective barrier is formed on the skin, the waterproof performance is good, makeup cannot be removed easily, the energy of ultraviolet rays is absorbed by a benzene ring and an electron-donating group and is excited to jump to a high energy state, the energy is emitted in weak long waves, the contact energy on the skin is small, and the skin has better capability of resisting UVB rays.

The addition of the phenylbenzimidazole sulfonic acid is a water-soluble sunscreen agent, so that the phenylbenzimidazole sulfonic acid has good permeability on the skin, and the phenylbenzimidazole sulfonic acid generates a benzene ring, a desulfonation group and a ring-opening oxidation product under ultraviolet rays, so that high energy of the ultraviolet rays of the phenylbenzimidazole sulfonic acid is converted into low energy to be released, and the skin can obtain the capability of resisting UVB rays.

By adding phenyl salicylate, the sun-proof wave band of the phenyl salicylate is 280-330nm, and molecular rearrangement occurs after certain ultraviolet energy is absorbed, so that a stronger ultraviolet-resistant structure is formed, and the skin is not easy to be sunburned by high energy to cause red swelling and blacking.

By adding the broad-spectrum sunscreen agent, the broad-spectrum sunscreen agent can resist UVA rays and UVB rays at the same time, so that the sunscreen emulsion has the capability of resisting both UVB rays and UVA rays, and has multiple sunscreen functions.

By adding the emulsifier, the emulsifier can form a molecular film on a water-oil interface formed by mixing the components, so that the surface tension of the water-oil interface is well reduced, the components can be well fused, and the state of the sunscreen emulsion is stable.

By adding the phenylbenzimidazole sulfonic acid, the dosage of p-diethylhexyl butamido triazone and phenyl salicylate in the sunscreen emulsion is reduced, the content of the oil-soluble sunscreen agent in the sunscreen emulsion is reduced, and the sunscreen emulsion has fresh and non-greasy skin feel.

By adding the coordination of diethyl hexyl butamido triazone, phenyl benzimidazole sulfonic acid and phenyl salicylate, the sunscreen emulsion has higher absorption intensity on UVB rays, so that the skin has better capability of resisting the UVB rays, the phenyl salicylate relieves the inhibition effect of the phenyl benzimidazole sulfonic acid on the absorption intensity of the diethyl hexyl butamido triazone, also improves the absorption intensity of the sunscreen emulsion on the UVB rays, obviously improves the absorption intensity of the sunscreen emulsion on the UVB rays, and ensures that the skin has better capability of resisting ultraviolet rays.

The present application may be further configured in a preferred example to: the paint also comprises the following components in parts by mass:

0.15-0.25 part of conditioner;

the conditioner is one or a compound of capric acid glyceride, octyl hydroximic acid and octyl glycol.

By adopting the technical scheme, the capric acid glyceride is mild vegetable oil, and the capric acid glyceride can remove free radicals to a certain extent, so that the photoaging of the skin caused by UVA rays is relieved, and the sun block has a certain photoaging resistant effect.

The octyl glycol is a substance extracted from plants, and is diffused from the lower layer of the skin to the stratum corneum to hydrate with the stratum corneum, so that secondary bound water in the stratum corneum is protected, the barrier function of the stratum corneum is better, and the sunscreen lotion has a certain effect of protecting the skin barrier.

By adding octyl hydroximic acid, octyl hydroximic acid can destroy the structure of microbial cells and decompose the cell membranes of the microbes, so that the skin barrier still has the capability of resisting bacteria after being damaged by ultraviolet irradiation, and the sunscreen milk has a certain antibacterial effect.

By adding the capric acid glyceride, the octyl hydroximic acid and the octyl glycol, the sun-screening lotion has various conditioning effects on the skin, the octyl hydroximic acid relieves the inhibiting effect of the octyl glycol on the photoaging resistance effect of the capric acid glyceride, the barrier function of the skin is better, and the sun-screening lotion has multiple after-sun repairing effects.

0.03-0.06 part of capric acid glyceride;

0.005-0.01 part of octyl hydroximic acid;

0.03-0.05 part of octyl glycol.

By adopting the technical scheme, the sunscreen lotion has better multiple after-sun repair effect through the matching of the tricaprin, the octyl hydroximic acid and the octyl glycol in a specific proportion.

7.5-9.5 parts of an emollient;

the emollient is a compound of one or more of octyl dodecanol, tribehenate and isomeric hexadecane.

By adding the octyl dodecanol, the octyl dodecanol has a transdermal promotion effect, so that the octyl dodecanol can better permeate into the stratum corneum and act on the stratum corneum, and the skin surface layer becomes soft.

By adding the Sanbehen essence, which is a nonionic wax and has good skin compatibility, the Sanbehen essence can better moisten the skin, so that the skin is not easy to lose water and becomes dry along with the lapse of ultraviolet irradiation time.

By adding the isomeric hexadecane, the isomeric hexadecane has good compatibility with oil on the surface of the skin, so that the skin is kept soft and smooth, and the isomeric hexadecane does not contain aromatic hydrocarbon and sulfur, so that the isomeric hexadecane has no stimulation to the skin and fresh skin feel, and the experience effect of sensitive skin is better.

By matching octyl dodecanol, Sanshan essence and isomeric hexadecane, the sunscreen lotion has multiple effects of good compatibility with skin, better penetration into stratum corneum, small irritation to skin, refreshing skin feel and the like, and has better moisturizing property to skin.

0.4-0.8 part of preservative.

By adopting the technical scheme, the preservative can destroy the structure of microorganisms by adding the preservative, so that the growth and proliferation of bacteria are inhibited, and the shelf life of the sun-screening milk is prolonged.

1.6-2.2 parts of titanium dioxide;

0.9-1.3 parts of ethylhexyl triazone;

5.5-6.5 parts of methylene bis-benzimidazolyl tetramethyl butyl phenol.

By adopting the technical scheme, the titanium dioxide is added, the titanium dioxide is a broad-spectrum sunscreen agent, has a certain sunscreen effect on both UVA rays and UVB rays, and ultraviolet rays are reflected by the titanium dioxide before reaching the surface of the skin, so that the sunscreen effect is achieved.

By adding the ethylhexyl triazone, the ethylhexyl triazone has better affinity to keratin, so that the sunscreen has better affinity to skin and is not easy to remove makeup.

By adding methylene bis-benzimidazolyl tetramethylbutylphenol, the protection effect of the methylene bis-benzimidazolyl tetramethylbutylphenol at the sunscreen wavelength of 280-400nm and at the wavelengths of 303nm and 358nm is optimal, so that the skin can resist the irradiation of UVA rays.

Through the coordination of titanium dioxide, ethylhexyl triazone and methylene bis-benzimidazolyl tetramethyl butyl phenol, the skin can obtain the capability of resisting UVA rays, and the irritation of the sun-screening lotion is reduced, so that the sun-screening lotion has better toxicological safety and sun-screening effect.

1.3-1.7 parts of a thickening agent;

the thickening agent is one or a compound of more of transparent xanthan gum, hydroxyethyl acrylate/acryloyl dimethyl sodium taurate copolymer, squalane and polysorbate-60.

By adopting the technical scheme, the transparent xanthan gum is added, so that the viscosity of the sunscreen lotion is increased, and the sunscreen lotion has stable viscosity.

By adding the hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, the hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer has a thickening effect and keeps smooth hand feeling, so that the sunscreen emulsion has good skin feeling in use.

By adding squalane, stimulation and allergy to human bodies are not easy to cause, and strong chemical stability is kept, so that the sunscreen lotion has good skin feeling and is mild to the skin.

By adding polysorbate-60, polysorbate-60 contains polysorbate with 60 oxyethylene units, the thickening system is stabilized, and the sunscreen emulsion has good stability.

Through the matching of transparent xanthan gum, hydroxyethyl acrylate/acryloyl dimethyl taurate copolymer, squalane and polysorbate-60, the thickening system has various effects of stable viscosity, mild skin, good use feeling and the like.

8-12 parts of a humectant.

By adopting the technical scheme, the humectant is added, so that the water-retaining components of the cells exposed to sunlight are not easy to lose in large quantity, and the problem of dryness of the skin is reduced.

The present application may be further configured in a preferred example to: the method comprises the following steps:

step 1-1), mixing and preheating titanium dioxide, ethylhexyl triazone, diethyl hexyl butamido triazone, phenyl salicylate and an emulsifier to 70-90 ℃, preserving heat for 10-20 minutes, and stirring until the mixture is completely and uniformly mixed to obtain a first mixture;

step 1-2), uniformly mixing the pH regulator, phenylbenzimidazole sulfonic acid and 60% -80% of deionized water, stirring and heating to 75-90 ℃, homogenizing for 4-8 minutes, and preserving heat for 25-35 minutes to obtain a second mixture;

step 1-3), dissolving methylene bis-benzimidazolyl tetramethyl butyl phenol by using 20-40% of deionized water to obtain a third mixture;

step 2), adding the first mixture into the second mixture, and stirring and homogenizing for 3-8 minutes to obtain a fourth mixture;

step 3), cooling the fourth mixture to 35-55 ℃, adding the third mixture, and uniformly stirring to obtain the sun block;

steps 1-1, 1-2 and 1-3 may be performed simultaneously or sequentially.

By adopting the technical scheme, the titanium dioxide, the ethylhexyl triazone, the diethyl hexyl butamido triazone and the phenyl salicylate are mixed and preheated to 70-90 ℃, so that active ingredients of the components are not easily damaged in the mixing process, and the emulsifier can better exert emulsification to form a first mixture.

The pH regulator, the phenylbenzimidazole sulfonic acid and 60% -80% of deionized water are uniformly mixed, stirred and heated to 75-90 ℃, homogenized for 4-8 minutes, and kept for 25-35 minutes, so that the neutralization effect is better, and a second mixture is formed.

Adding the first mixture into the second mixture, stirring and homogenizing for 3-8 minutes to ensure that the composition is mixed more uniformly to obtain a stable fourth mixture;

the fourth mixture is cooled to 35-55 ℃ and then added into the third mixture, so that the activity of the composition is not easily damaged, and the sunscreen emulsion is formed.

The present application may be further configured in a preferred example to: the method is characterized in that: in the step 1-1), octyl dodecanol, behenyl alcohol, isomeric hexadecane, hydroxyethyl acrylate/acryloyl dimethyl sodium taurate copolymer, squalane and polysorbate-60 are also added, the mixture is preheated to 70-90 ℃, stirred until the mixture is completely and uniformly mixed, and cooled for later use;

adding transparent xanthan gum and a humectant in the step 1-2), stirring and heating to 75-90 ℃, homogenizing for 4-8 minutes, and keeping the temperature for 25-35 minutes;

in the step 3), a preservative is also added and stirred uniformly.

By adopting the technical scheme, the active ingredients of the composition are not easily damaged by preheating to 70-90 ℃ in the step 1-1).

In the step 1-2), the temperature is heated to 75-90 ℃ so that the activity of each component is not easily damaged, and the stability of the composition is better by keeping the temperature for 25-35 minutes.

In summary, the present application has the following beneficial effects:

1. by adding the phenyl salicylate, the phenyl salicylate relieves the inhibition effect of the phenylbenzimidazole sulfonic acid on the absorption intensity of the diethylhexyl butamido triazone, also improves the absorption intensity, and obviously improves the absorption intensity of the sunscreen emulsion.

2. By adding the coordination of tricaprin, octyl hydroximic acid and octyl glycol, the sunscreen emulsion has multiple after-sun repair effects.

3. The sun-screening cream has better moistening property to the skin through the matching of octyl dodecanol, Sanshan refined and heterogeneous hexadecane.

Detailed Description

The present application will be described in further detail with reference to examples.

The information on the source of the main raw material components in the following examples and comparative examples is shown in Table 1

TABLE 1

Examples 1 to 4: a sunscreen emulsion comprises the following components:

titanium dioxide, ethylhexyl triazone, methylene bis-benzimidazolyl tetramethyl butylphenol, diethyl hexyl butamido triazone, phenyl benzimidazole sulfonic acid, phenyl salicylate, emulsifier, sodium hydroxide and deionized water.

In examples 1-4, the amounts (in Kg) of each component added are specified in Table 2

TABLE 2

The preparation method of the sunscreen of examples 1-4 includes the following steps:

step 1: the pretreatment specifically comprises the following steps:

step 1-1), adding titanium dioxide, ethylhexyl triazone, diethyl hexyl butamido triazone and phenyl salicylate into a first stirring kettle at a rotating speed of 80r/min, heating to 85 ℃ while stirring, stirring for 10 minutes, and naturally cooling to 45 ℃ to obtain a first premix;

step 1-2), adding sodium hydroxide into a second stirring kettle, adding 20% deionized water, stirring for 2 minutes at a rotating speed of 20r/min, and then adding phenylbenzimidazole sulfonic acid into the second stirring kettle, stirring for 15 minutes at a rotating speed of 20r/min to obtain a second premix;

step 1-3), adding methylene bis-benzimidazolyl tetramethyl butyl phenol into a third stirring kettle, and dissolving with 20% deionized water to obtain a third premix;

the method comprises the following steps: the mixing treatment specifically comprises the following steps:

step 2-1), adding the cetostearyl glucoside and potassium cetyl phosphate into a first stirring kettle at the rotating speed of 100r/min, heating to 85 ℃ while stirring, stirring for 30 minutes, and then preserving heat at 85 ℃ for 15 minutes to obtain a first mixture;

step 2-2), adding 60% of deionized water into the second premix, rotating at a speed of 120r/min, heating to 85 ℃ while stirring, stirring for 20 minutes, moving into a first homogenizer for homogenizing for 20 minutes, and preserving heat at 85 ℃ for 30 minutes to obtain a second mixture;

step 3), adding the first mixture into the second mixture, stirring for 10 minutes at a rotating speed of 80r/min, and then transferring into a second homogenizer for homogenizing for 5 minutes to obtain a third mixture;

and 4) naturally cooling the third mixture to 45 ℃, adding the third pre-mixture into the third mixture, rotating at 60r/min, and stirring for 5 minutes to obtain the sun-block milk.

Example 5

Compared with example 2, the difference is only that:

in the step 1-1), the temperature is firstly increased to 90 ℃, and then is reduced to 50 ℃.

In step 4), the temperature of the third mixture is reduced to 50 ℃.

Example 6

Compared with example 2, the difference is only that:

in the step 1-1), the temperature is firstly increased to 82 ℃ and then reduced to 43 ℃.

In step 4), the temperature of the third mixture is reduced to 43 ℃.

Examples 7 to 10

Compared with example 2, the difference is only that: the components of the sunscreen also include a conditioning agent.

The conditioner is a compound of ceramide NP, phytosphingosine, cholesterol, stearic acid, oleic acid, lactic acid, caprylic/capric glyceride, hydrogenated lecithin, octyl hydroximic acid, octyl glycol and VE natural tocopherol.

In examples 7 to 9, the amounts (in Kg) of the respective components added are specified in Table 3

TABLE 3

	Example 7	Example 8	Example 9	Example 10
					Ceramide NP	0.002	0.003	0.004	0.005
Phytosphingosine	0	0.001	0.002	0.003
					Cholesterol	0.001	0.0012	0.0014	0
Stearic acid	0	0.001	0.0015	0.002
					Oleic acid	0.001	0.002	0	0.003
Lactic acid	0.002	0	0.0028	0.003
					Caprylic/capric glycerides	0.03	0.04	0.05	0.06
Hydrogenated lecithin	0.001	0.002	0.003	0.004
					Octyl hydroximic acid	0.005	0.007	0.009	0.01
Octylethylene glycol	0.03	0.035	0.04	0.05
					VE natural tocopherol	0.078	0.085	0.1	0.11

VE natural tocopherol is added to the first stirred tank in step 1-1) together with titanium dioxide.

Ceramide NP, phytosphingosine, cholesterol, stearic acid, oleic acid, lactic acid, caprylic/capric glycerides, hydrogenated lecithin, octylhydroxamic acid, octylethylene glycol, and VE natural tocopherol are stirred in step 4) with the third mixture, the third premix, and uniformly.

Examples 11 to 14

Compared with example 2, the difference is only that: the components of the sun protection cream also comprise an emollient.

The emollient is a compound of silicone oil, octyl dodecanol, Sanbehen essence and isomeric hexadecane.

In examples 11 to 14, the amounts (in Kg) of the respective components added are specified in Table 4

TABLE 4

	Example 11	Example 12	Example 13	Example 14
					Silicone oil	1	1.5	2	2.5
Octyl dodecanol	3.5	4	5	5.5
					Sanshan wasabin essence	1.5	2	2.2	2.5
Isomeric hexadecanes	3.5	4	4.2	4.5

Octyl dodecanol, behenyl trisaccharide and isomeric hexadecane were added to the first stirred tank in step 1-1) along with titanium dioxide.

The silicone oil was added to the first stirred tank in step 2-1) together with cetostearyl glucoside and potassium cetyl phosphate.

Examples 15 to 18

Compared with example 2, the difference is only that: the components of the sunscreen emulsion also comprise a preservative.

The preservative is a compound of chlorphenesin and phenoxyethanol.

In examples 15 to 18, the amounts (in Kg) of the components added are specified in Table 5

TABLE 5

	Example 15	Example 16	Example 17	Example 18
					Chlorophytidine ester	0.2	0.3	0.35	0.4
Phenoxyethanol	0.2	0.3	0.35	0.4

The chlorphenesin and the phenoxyethanol are uniformly stirred together with the third mixture and the third pre-mixture in the step 4).

Examples 19 to 22

Compared with example 2, the difference is only that: the components of the sunscreen emulsion also comprise a thickening agent.

The thickening agent is a compound of transparent xanthan gum, hydroxyethyl acrylate/acryloyl dimethyl sodium taurate copolymer, squalane, polysorbate-60 and magnesium aluminum silicate.

In examples 19 to 22, the amounts (in Kg) of the respective components added are specified in Table 6

TABLE 6

Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, squalane and polysorbate-60 were added to the first stirred tank together with titanium dioxide in step 1-1).

Transparent xanthan gum and magnesium aluminum silicate are added to the second premix in step 2-2) together with deionized water.

Examples 23 to 26

Compared with example 2, the difference is only that: the components of the sunscreen emulsion also comprise a humectant.

The humectant is compounded by glycerin and propylene glycol.

In examples 23 to 26, the amounts (in Kg) of the respective components charged are specified in Table 7

TABLE 7

Glycerin, propylene glycol were added to the second premix in step 2-2) along with deionized water.

Examples 27 to 30

Compared with example 2, the difference is only that:

the components of the sunscreen emulsion also comprise ethylhexyl methoxycinnamate, polyhydroxystearic acid, methylene bis-benzotriazolyl tetramethylbutylphenol, conditioning agents, emollients, preservatives, thickeners, humectants, chelating agents and fragrances.

The conditioner is compounded with ceramide NP, phytosphingosine, cholesterol, stearic acid, oleic acid, lactic acid, caprylic/capric glyceride, hydrogenated lecithin, octyl hydroximic acid and octyl glycol.

The preservative is a compound of chlorphenesin and phenoxyethanol.

The humectant is prepared by compounding glycerol and propylene glycol.

The chelating agent is disodium ethylene diamine tetraacetate.

The perfume is neroli essential oil.

In examples 30 to 33, the amounts (in Kg) of the respective components added are specified in Table 8

TABLE 8

Octyl dodecanol, hexyl methoxycinnamate, behenyl, isomeric hexadecane, VE natural tocopherol, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, squalane, polysorbate-60 are added into a first stirring kettle together with titanium dioxide in the step 1-1);

adding the silicone oil and the hexa-octadecyl glucoside and potassium cetyl phosphate which are added into the first stirring kettle in the step 2-1) into the first stirring kettle;

adding glycerol, disodium ethylene diamine tetraacetate, propylene glycol, transparent xanthan gum and magnesium aluminum silicate into the second premix together with 60% of deionized water in the step 2-2);

neroli essential oil, ceramide NP, phytosphingosine, cholesterol, stearic acid, oleic acid, lactic acid, caprylic/capric glycerides, hydrogenated lecithin, octylhydroxamic acid, caprylyl glycol were added to the third mixture in step 4) with the third premix.

Comparative example 1

Compared with example 2, the difference is only that:

in the step 1-1), the diethyl hexyl butamido triazone and phenyl salicylate are equivalently replaced by deionized water.

In the step 1-2), the phenyl benzimidazole sulfonic acid is replaced by deionized water in an equal amount.

Comparative example 2

Compared with example 2, the difference is only that:

in the step 1-1), the phenyl salicylate is replaced by deionized water in equal amount.

Comparative example 3

Compared with example 2, the difference is only that:

in the step 1-1), the ethylhexyl butamido triazone and phenyl salicylate are equivalently replaced by deionized water.

Comparative example 4

Compared with example 2, the difference is only that:

in step 1-1), diethylhexyl butamido triazone was replaced with deionized water in equal amounts.

Comparative example 5

Compared with example 2, the difference is only that:

Comparative example 6

Compared with example 2, the difference is only that:

in the step 1-1), the phenyl benzimidazole sulfonic acid is replaced by deionized water in equal amount.

Comparative example 7

Compared with example 2, the difference is only that:

in step 1-2), diethylhexyl butamido triazone was replaced with deionized water in equal amounts.

Comparative example 8

Compared with example 8, the difference is only that:

in the step 4), the glycerol caprylate/caprate, the octyl hydroximic acid and the octyl glycol are equivalently replaced by deionized water.

Comparative example 9

Compared with example 2, the difference is only that:

in the step 4), octyl hydroximic acid and octyl glycol are equivalently replaced by deionized water.

Comparative example 10

Compared with example 2, the difference is only that:

in the step 4), the equivalent amount of the deionized water is used for replacing the caprylic/capric glyceride and the caprylyl glycol.

Comparative example 11

Compared with example 2, the difference is only that:

in the step 4), the capryl/capric glyceride, the octyl hydroximic acid and the deionized water are equivalently replaced.

Comparative example 12

Compared with example 2, the difference is only that:

in the step 4), the octyl glycol is replaced by deionized water with equal amount.

Comparative example 13

Compared with example 2, the difference is only that:

in step 4), octyl hydroxamic acid was replaced with deionized water in equal amounts.

Comparative example 14

Compared with example 2, the difference is only that:

in step 4), equivalent amount of deionized water is used to replace the caprylic/capric glyceride.

Experiment 1

The sunscreen creams prepared in each example and comparative example were tested for safety according to technical cosmetic safety standards (2015 edition). The microbial assay data are detailed in table 9:

TABLE 9

According to the detection data in table 9, the safety performance detection of the sunscreen emulsions prepared in examples 1-30 and comparative examples 1-7 meets the standard requirements, and the sunscreen emulsions are not easy to cause harm to human bodies.

Experiment 2

The sunscreen effect of the sunscreen emulsion prepared in each of the examples and comparative examples was examined according to the determination method of sun protection index of the U.S. Food and Drug Administration (FDA) standard ISO 24444-2010.

The test method comprises the following steps: 112 skin health volunteers without a history of allergic diseases were randomly selected, aged 18-60 years, and randomly divided into 37 groups, 3 individuals were selected, No. 1, No. 2 and No. 3 were randomly ordered, a solar simulator xenon arc lamp was selected as a light source, the sunscreen prepared in each example and comparative example was applied to the back of the subject at a dose of (2.0 ± 0.1) mg/cm2 under a light source of the same wavelength band of 275-320 nm, the test area was 5cm x 5cm, the MED value of the skin was measured, and the evaluation result was represented by the average value of each person. The assay data are detailed in table 10:

watch 10

According to the comparison of the data of comparative example 2 and comparative example 1 in Table 10, the addition of diethylhexyl butamido triazone greatly improves the minimum erythema amount, which indicates that the absorption intensity of diethylhexyl butamido triazone to UVB ray is larger, so that the sun protection intensity is improved.

As can be seen from comparison of the data in Table 10 in comparative example 3 with that in comparative example 1, the minimum erythema dose was also greatly improved by adding phenylbenzimidazole sulfonic acid, which shows that the absorption intensity of UVB rays by phenylbenzimidazole sulfonic acid is also large, so that the sun protection intensity is improved.

As can be seen from comparison of the data in Table 10 in comparative example 4 with that in comparative example 1, the addition of phenyl salicylate partially increased the minimum erythema level, indicating that phenyl salicylate had a certain absorption intensity of UVB rays, resulting in a certain increase in sunscreen intensity.

According to the comparison of the data of comparative example 5 and comparative examples 2 and 3 in table 10, the addition of phenylbenzimidazole sulfonic acid and diethylhexyl butamido triazone results in a smaller minimum erythema amount, which indicates that the phenylbenzimidazole sulfonic acid has an inhibitory effect on diethylhexyl butamido triazone, and the absorption intensity of UVB rays is reduced, thereby reducing the sun protection intensity of the sunscreen.

As can be seen from comparison of the data of comparative example 6 and comparative example 2 in Table 10, the minimum erythema dose was substantially unchanged by the addition of phenyl salicylate, indicating that the effect of phenyl salicylate on the absorption strength of diethylhexyl butamido triazone was small.

As can be seen from comparison of the data of comparative example 7 and comparative example 3 in Table 10, the minimal erythema dose was substantially unchanged by the addition of phenyl salicylate, indicating that the effect of phenyl salicylate on the absorption strength of phenylbenzimidazole sulfonic acid was small.

According to the comparison of the data of examples 1 to 4 and comparative example 5 in table 10, the addition of phenyl salicylate greatly increases the minimum erythema amount, which indicates that phenyl salicylate relieves the mutual inhibition between diethylhexyl butamido triazone and phenyl benzimidazole sulfonic acid, and causes the synergistic effect between diethylhexyl butamido triazone and phenyl benzimidazole sulfonic acid, so that the absorption intensity of the sunscreen against UVB rays is greatly increased, and the sunscreen intensity of the sunscreen is increased.

Experiment 3

Taking staphylococcus aureus bacterial liquid with about 3 hundred million bacteria per ml from a sterilized cotton swab, taking parallel cross-scribing from different directions by taking the whole cotton swab as a degree just soaked, uniformly coating the bacterial liquid on the whole agar plate, taking 0.05g/ml of liquid to be tested prepared from the sun-proof emulsion prepared in each embodiment and comparative example, placing the liquid to be tested on different areas of the surface of the agar plate, placing a culture dish in an incubator, culturing for 24 hours at the temperature of 37 ℃, observing and measuring the diameter of a bacteria inhibition ring, and taking an average value.

Experiment 4

Taking 3mL of DPPH-anhydrous methanol solution with the concentration of 0.0178mmol/L, adding 3mL of solution to be detected prepared from the sun-proof emulsion prepared in each example and each comparative example, uniformly mixing, immediately detecting the light absorption value at the wavelength of 517nm, marking the light absorption value as A1, then storing the solution at 37 ℃ in the dark for 30min, marking the solution as A2, and calculating the light absorption value of a blank control group by only adding DPPH-anhydrous methanol solution, marking the light absorption value as A3 according to the following formula: DPPH free radical clearance (%) [1- (a1-a2)/A3] × 100%, and an average of three measurements was taken.

Experiment 5

The anti-inflammatory reaction of each example or each comparative example was evaluated by adding an equal amount of 0.25% Sodium Dodecyl Sulfate (SDS) to the sunscreen milk, observing the degree of injury to the skin module after 24 hours, examining the amount of IL-lalpha (cytokine) at a wavelength of 450nm using an ELISA microplate reader, immediately measuring the absorbance according to comparative example 1 as a reference value, and dividing the absorbance of the sunscreen milk of each example or each comparative example by the reference value and multiplying by 100% to determine the absorbance.

The data from experiments 3-5 are detailed in Table 11

TABLE 11

According to the comparison of the data of comparative example 9 and comparative example 8 in table 11, the free radical scavenging rate is obviously improved by adding the caprylic/capric glyceride, which shows that the caprylic/capric glyceride has a better effect on resisting photoaging, so that the sunscreen emulsion has the effect of resisting photoaging.

As can be seen from a comparison of the data in Table 11 for comparative example 10 and comparative example 8, the absorbance was significantly increased with the addition of capryl glycol, indicating that capryl glycol has a beneficial effect in protecting the skin barrier, making the sunscreen less prone to skin damage and becoming sensitive.

According to the comparison of the data of comparative example 11 and comparative example 8 in table 11, the diameter of the bacteriostatic ring is significantly increased by adding octyl hydroximic acid, which indicates that octyl hydroximic acid has a better bacteriostatic effect, so that the sunscreen lotion has a bacteriostatic effect.

As can be seen from comparison of the data in Table 11 in comparative example 12 with those in comparative examples 9 and 10, the addition of capryl glycol and capryl/capric glyceride resulted in a decrease in the diameter of the antibacterial ring and in the radical scavenging rate, indicating mutual inhibition between capryl glycol and capryl/capric glyceride.

As can be seen from comparison of the data in Table 11 for comparative example 13 with comparative examples 9 and 11, radical clearance and absorbance were essentially unchanged with the addition of octyl hydroxamic acid, indicating a small effect between octyl hydroxamic acid and caprylic/capric glycerides.

As can be seen from comparison of the data in Table 11 in comparative example 14 with comparative examples 10 and 11, the addition of octyl hydroxamic acid resulted in substantially unchanged bacteriostatic ring diameter and absorbance, indicating that the effect between octyl hydroxamic acid and octyl glycol was small.

According to the comparison of the data of examples 7-10 and comparative example 12 in table 11, the radical clearance rate is significantly improved and the diameter of the inhibition ring is significantly increased by adding octyl hydroximic acid, which indicates that octyl hydroximic acid relieves the mutual inhibition between capryl/capric glyceride and capryl glycol and enables the synergistic effect between capryl/capric glyceride and capryl glycol, thereby enabling the sunscreen to have multiple repairing functions.

From the comparison of the data in Table 10 for examples 11-14 with example 8, the absorbance was slightly increased by the addition of emollient, indicating that the emollient lotion has some effect on protecting the barrier.

According to the comparison of the data of examples 15-18 and example 8 in Table 10, the diameter of the bacteriostatic ring becomes larger by adding the preservative, which shows that the preservative makes the bacteriostatic effect of the sunscreen milk better.

From a comparison of the data in Table 10 for examples 19-22 with example 8, no significant negative effects were observed in radical clearance, bacteriostatic ring diameter and absorbance by the addition of the thickener, indicating that the thickener had less of an effect on the maintenance function of the sunscreen.

From a comparison of the data in Table 10 for examples 23-26 with example 8, it can be seen that by adding the humectant, there was no significant negative effect on the radical scavenging rate, bacteriostatic ring diameter and absorbance, indicating that the humectant had less effect on the repair function of the sunscreen.

The present embodiment is only for explaining the present application, and it is not limited to the present application, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present application.

Claims

1. A sun block which is characterized in that: the paint comprises the following components in parts by mass:

8-10 parts of a broad-spectrum sunscreen agent;

5-7.5 parts of diethyl hexyl butamido triazone;

2-4 parts of phenylbenzimidazole sulfonic acid;

0.5-0.7 part of phenyl salicylate;

1.5-2.5 parts of an emulsifier;

0.3-0.5 part of pH regulator;

45-55 parts of deionized water.

2. The suncare emulsion of claim 1, wherein: the paint also comprises the following components in parts by mass:

0.15-0.25 part of conditioner;

3. A sun-protecting cream according to claim 2, characterized in that: the conditioner comprises the following components in parts by mass:

0.03-0.06 part of capric acid glyceride;

0.005-0.01 part of octyl hydroximic acid;

0.03-0.05 part of octyl glycol.

4. The suncare emulsion of claim 1, wherein: the sun-screening milk also comprises the following components in parts by mass:

7.5-9.5 parts of an emollient;

5. The suncare emulsion of claim 1, wherein: the sunscreen emulsion comprises the following components in parts by mass:

0.4-0.8 part of preservative.

6. The suncare emulsion of claim 1, wherein: the broad-spectrum sunscreen agent also comprises the following components in parts by mass:

1.6-2.2 parts of titanium dioxide;

0.9-1.3 parts of ethylhexyl triazone;

5.5-6.5 parts of methylene bis-benzimidazolyl tetramethyl butyl phenol.

7. The high absorption intensity sunscreen according to claim 1 wherein: the sun-screening milk also comprises the following components in parts by mass:

1.3-1.7 parts of a thickening agent;

8. The suncare emulsion of claim 1, wherein: the sun-screening milk also comprises the following components in parts by mass:

8-12 parts of a humectant.

9. The method of preparing a sun-protecting cream according to claim 1, wherein: the method comprises the following steps:

step 1-3), dissolving methylene bis-benzimidazolyl tetramethylbutylphenol by using 20-40% of deionized water to obtain a third mixture;

steps 1-1, 1-2 and 1-3 may be performed simultaneously or sequentially.

10. A sun-protecting cream according to claim 9, characterized in that: in the step 1-1), octyl dodecanol, behenyl alcohol, isomeric hexadecane, hydroxyethyl acrylate/acryloyl dimethyl sodium taurate copolymer, squalane and polysorbate-60 are also added, the mixture is preheated to 70-90 ℃, stirred until the mixture is completely and uniformly mixed, and cooled for later use;

in the step 3), a preservative is also added and stirred uniformly.