CN111948000A - Full-automatic thallus diaphragm preparation system - Google Patents
Full-automatic thallus diaphragm preparation system Download PDFInfo
- Publication number
- CN111948000A CN111948000A CN201910402602.2A CN201910402602A CN111948000A CN 111948000 A CN111948000 A CN 111948000A CN 201910402602 A CN201910402602 A CN 201910402602A CN 111948000 A CN111948000 A CN 111948000A
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- Prior art keywords
- slide
- automatic
- full
- thallus
- specimen
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- 238000002360 preparation method Methods 0.000 title claims abstract description 26
- 239000007788 liquid Substances 0.000 claims abstract description 20
- 230000001580 bacterial effect Effects 0.000 claims abstract description 17
- 238000011068 loading method Methods 0.000 claims abstract description 16
- 239000012528 membrane Substances 0.000 claims description 27
- 239000011521 glass Substances 0.000 claims description 17
- 239000003292 glue Substances 0.000 claims description 10
- 238000012545 processing Methods 0.000 claims description 9
- 238000005070 sampling Methods 0.000 claims description 6
- 238000000926 separation method Methods 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 5
- 239000007924 injection Substances 0.000 claims description 5
- 238000005406 washing Methods 0.000 claims description 5
- 238000004887 air purification Methods 0.000 claims description 4
- 241001052560 Thallis Species 0.000 claims description 2
- 239000005394 sealing glass Substances 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 7
- 238000001179 sorption measurement Methods 0.000 abstract description 6
- 238000004043 dyeing Methods 0.000 abstract description 5
- 238000003912 environmental pollution Methods 0.000 abstract description 3
- 238000007599 discharging Methods 0.000 abstract description 2
- 238000005516 engineering process Methods 0.000 abstract description 2
- 238000001514 detection method Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000010586 diagram Methods 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 206010036790 Productive cough Diseases 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 210000003802 sputum Anatomy 0.000 description 2
- 208000024794 sputum Diseases 0.000 description 2
- 238000000967 suction filtration Methods 0.000 description 2
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000012993 chemical processing Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N1/31—Apparatus therefor
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Sampling And Sample Adjustment (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The invention belongs to the technical field of preparation of thallus diaphragms, and particularly relates to a full-automatic thallus diaphragm preparation system which comprises a box body, wherein an operation table is arranged on one side of the box body, a liquid sucking and injecting system, a glue-attached instilling system, a slide loading system, a diaphragm transferring system, a slide collecting system, a reaction and temperature control system and a sample transferring and transferring system are arranged at the top end of the operation table, an air discharging system is arranged at the top end of the box body, and a data control screen is arranged at the top end of the outer wall on one side of the box body. The invention utilizes the adsorption film transfer technology to integrate the bacterial adsorption flaking and dyeing, greatly improves the working efficiency, has high bacterial adsorption rate, good flaking effect and about 2 times higher bacterial detection rate, and the bacterial specimen is completely closed in the whole experimental process without environmental pollution.
Description
Technical Field
The invention relates to the technical field of thallus diaphragm preparation, in particular to a full-automatic thallus diaphragm preparation system.
Background
At present, tuberculosis is pathogenic, and the examination of tubercle bacillus is the traditional sputum specimen slide direct coating method or the centrifugal concentration method. The direct coating method is complicated, and the operation requires that an experimenter directly contacts the sputum specimen with extremely strong infectivity to make a smear, and the smear is directly and manually dyed, so that the method has high safety risk, low working efficiency, poor making result and high omission ratio.
The efficiency of flaking of centrifugal concentration method is higher than direct coating method, and the step is three big steps of bacterium collection, flaking, dyeing, and each step all has the laboratory staff to participate in by hand and the sample exposes in the laboratory, and the safety risk is very high, and the step is numerous and diverse, and the collection rate of bacterium is low, the rate of missing inspection is high.
Disclosure of Invention
Based on the technical problems provided by the background technology, the invention provides a full-automatic thallus diaphragm preparation system.
The full-automatic thallus diaphragm preparation system provided by the invention comprises a box body, wherein an operation table is arranged on one side of the box body, a liquid sucking and injecting system, a glue attaching and dripping system, a slide loading system, a diaphragm transferring system, a slide collecting system, a reaction and temperature control system and a specimen transferring and transferring system are arranged at the top end of the operation table, an air discharging system is arranged at the top end of the box body, and a data control screen is arranged at the top end of the outer wall on one side of the box body.
As a further aspect of the invention: the outer wall of one side of the box body is movably connected with a movable sealing glass cover.
As a further aspect of the invention: the air discharge system includes an air cleaning device.
As a further aspect of the invention: the specimen loading and transferring system comprises a specimen moving rotating disk and a specimen processing rotating disk.
As a further aspect of the invention: the slide loading system includes a slide loading bin.
As a further aspect of the invention: it drips gluey frame including intelligent slide to attach gluey instillation system, intelligence slide drips gluey frame and includes that the motor lead screw removes the subassembly, and lead screw outer wall has the pouring tube through threaded connection, and pouring tube sliding connection has fixed cover.
As a further aspect of the invention: the membrane transfer system comprises a membrane transfer rotating disk, and four glass slide rotating grippers are arranged on the outer wall of the membrane transfer rotating disk.
As a further aspect of the invention: the glass slide collecting system comprises a glass slide collector, the glass slide collector comprises a fixing frame and two glass slide clamping frames arranged at the top end of the fixing frame, and a glass slide clamping groove is formed between the glass slide clamping frames.
As a further aspect of the invention: the reaction and temperature control system comprises a temperature regulation and control device and a separation device of the specimen collector, and the temperature regulation and control device and the separation device of the specimen collector are arranged inside the specimen processing rotating disc.
As a further aspect of the invention: the liquid suction and injection system comprises a liquid sampling needle, a liquid washing and sample suction needle and a cylindrical coordinate type manipulator, and the liquid sampling needle is connected with a plurality of converters for different liquids.
The beneficial effects of the invention are as follows:
this system utilizes the adsorption film transfer technique, with bacterial adsorption film-making, dyeing in an organic whole, great improvement work efficiency, bacterial adsorption rate is high, the film-making is effectual, the bacterial relevance rate improves about 2 times to the bacterium sample is totally enclosed in whole experimental procedure, does not have environmental pollution.
Drawings
FIG. 1 is a schematic view of the overall structure of a full-automatic bacterial membrane preparation system according to the present invention;
FIG. 2 is a schematic structural view of an air discharge system of the full-automatic bacterial membrane preparation system according to the present invention;
FIG. 3 is a schematic structural diagram of a specimen transfer and transfer system of the full-automatic bacterial membrane preparation system provided by the invention;
FIG. 4 is a schematic structural diagram of a reaction and temperature control system of the full-automatic bacterial membrane preparation system provided by the present invention;
FIG. 5 is a schematic structural diagram of a slide collection system of the fully automatic bacterial membrane preparation system according to the present invention;
FIG. 6 is a schematic structural diagram of a slide transfer system of the full-automatic bacterial membrane preparation system provided by the present invention;
FIG. 7 is a schematic diagram of a glue dripping system of the full-automatic bacterial membrane preparation system according to the present invention.
In the figure: the device comprises an air discharge system 1, a box 2, a data control screen 3, a liquid suction and injection system 4, a glue dripping system 5, a slide loading system 6, a membrane transferring system 7, a slide collecting system 8, a reaction and temperature control system 9 and a specimen loading and transferring system 10.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.
Referring to fig. 1-7, full-automatic thalli diaphragm preparation system, including box 2, one side of box 2 is provided with the operation panel, and the operation panel top is provided with liquid suction and injection system 4, attaches glue instillation system 5, slide loading system 6, diaphragm transfer system, slide collection system 8, reaction and temperature control system 9 and sample reprint and transfer system 10, the top of box 2 is provided with air exhaust system 1, and the top of box 2 one side outer wall is provided with data control screen 3.
Wherein, one side outer wall swing joint of box 2 has the removal to seal the glass cover to can be when the user equipment, seal operation panel and laboratory environment through removing, avoid the surrounding environment influence.
The air discharge system 1 comprises an air purification device, and the air purification device is matched with a movable closed glass cover to shield the air in the whole box body from the pollution to the experimental environment.
The specimen loading and transfer system 10 includes a specimen moving carousel and a specimen processing carousel.
The slide loading system 6 includes a slide loading bin.
Attach and glue instillation system 5 and include that intelligence slide glass drips and glues the frame, intelligence slide glass drips and glues the frame and include that motor lead screw removes the subassembly, and the lead screw outer wall has the pouring tube through threaded connection, and pouring tube sliding connection has fixed cover to can attach gluey instillation through the intelligent lift completion of the mode that the electronic lead screw of motor removed.
The membrane transfer system 7 comprises a membrane transfer rotating disk, and the outer wall of the membrane transfer rotating disk is provided with four slide rotating grippers.
The slide collecting system 8 comprises a slide collector, the slide collector comprises a fixing frame and two slide clamping frames arranged at the top end of the fixing frame, and a slide clamping groove is formed between the slide clamping frames.
The reaction and temperature control system 9 comprises a temperature control device and a separation device of the specimen collector, and the temperature control device and the separation device of the specimen collector are arranged inside the specimen processing rotating disc.
The liquid suction and injection system 4 comprises a liquid sampling needle, a liquid washing suction needle and a cylindrical coordinate type manipulator, and the liquid sampling needle is connected with a plurality of converters for different liquids.
According to the invention, through the arrangement of the controller, the sample bottle moving rotating disc is matched with the manipulator to accurately place the target sample collector into the sample processing rotating disc, and the physical and chemical processing processes of multiple washing, dyeing and the like of the sample are completed; the membrane transfer turntable robot gripper, the slide loading system, the adhesive-attached instillation system and the slide glass collecting system are matched with each other to complete the transfer and collection of the specimen slide; air suction filtration system protective screen air in the whole box to experimental environment's pollution, and whole process need not manual operation, safe and reliable more.
During the use, fix equipment in suitable position, and connect the power, with the sample dress in with mobile system 10, manipulator and sample bottle removal rotary disk work, the sample in the sample bottle removal rotary disk shifts the sample to the sample processing rotary disk in reaction and temperature control system 9, and accomplish the washing of sample here and dyeing etc. and handle, the glass slide of film transfer carousel is placed in glass cell-phone system and is held the sample between the slide through mechanical tongs on the processing completion back film transfer rotary disk, it keeps apart through removing sealed glass cover to attach gluey instillation system 5 work thereby accomplish the whole work interval of preparation of sample slide, air exhaust system's air purification device carries out the suction filtration purification to the air, avoid laboratory environmental pollution.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (10)
1. Full-automatic thallus diaphragm preparation system, including box (2), its characterized in that, one side of box (2) is provided with the operation panel, and the operation panel top is provided with liquid and inhales notes system (4), attaches glue instillation system (5), slide loading system (6), diaphragm transfer system, slide collection system (8), reaction and temperature control system (9) and sample reprint and transfer system (10), the top of box (2) is provided with air discharge system (1), and the top of box (2) one side outer wall is provided with data control screen (3).
2. The full-automatic thallus membrane preparation system according to claim 1, characterized in that a movable sealing glass cover is movably connected with the outer wall of one side of the box body (2).
3. The fully automatic bacterial membrane preparation system according to claim 2, wherein said air discharge system (1) comprises an air purification device.
4. The fully automated bacterial membrane preparation system according to claim 3, wherein said specimen loading and transfer system (10) comprises a specimen moving rotating disk and a specimen processing rotating disk.
5. The fully automated bacterial membrane preparation system according to claim 4, wherein said slide loading system (6) comprises a slide loading chamber.
6. The full-automatic thallus membrane preparation system according to claim 5, wherein the adhesive-attached dripping system (5) comprises an intelligent glass slide glue dripping frame, the intelligent glass slide glue dripping frame comprises a motor lead screw moving assembly, the outer wall of the lead screw is connected with a pouring pipe through threads, and the pouring pipe is connected with a fixed sleeve in a sliding manner.
7. The full-automatic thallus membrane preparation system according to claim 6, wherein the membrane transfer system (7) comprises a membrane transfer rotating disc, and the outer wall of the membrane transfer rotating disc is provided with four slide rotating grippers.
8. The full-automatic thalli membrane preparation system of claim 7, wherein the slide collection system (8) comprises a slide collector, the slide collector comprises a fixed frame and two slide holding frames arranged at the top end of the fixed frame, and a slide holding groove is arranged between the slide holding frames.
9. The system for preparing the full-automatic thallus membrane according to claim 8, wherein the reaction and temperature control system (9) comprises a temperature control device and a separation device of the specimen collector, and the temperature control device and the separation device of the specimen collector are arranged inside the specimen processing rotating disc.
10. The full-automatic thallus membrane preparation system according to any one of claims 1-9, wherein the liquid suction and injection system (4) comprises a liquid sampling needle, a liquid washing suction needle and a cylindrical coordinate type manipulator, and the liquid sampling needle is connected with a plurality of converters for different liquids.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910402602.2A CN111948000A (en) | 2019-05-15 | 2019-05-15 | Full-automatic thallus diaphragm preparation system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910402602.2A CN111948000A (en) | 2019-05-15 | 2019-05-15 | Full-automatic thallus diaphragm preparation system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111948000A true CN111948000A (en) | 2020-11-17 |
Family
ID=73336615
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910402602.2A Pending CN111948000A (en) | 2019-05-15 | 2019-05-15 | Full-automatic thallus diaphragm preparation system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111948000A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113777288A (en) * | 2021-09-14 | 2021-12-10 | 中国人民解放军总医院第八医学中心 | Mycobacterium tuberculosis automatic check out test set |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201255707Y (en) * | 2008-04-23 | 2009-06-10 | 珠海市丽拓发展有限公司 | Cell slide-making staining machine |
| CN201449349U (en) * | 2009-04-24 | 2010-05-05 | 珠海福生医疗器械有限公司 | Automatic liquid based lamina cell smear machine |
| CN103558071A (en) * | 2013-11-08 | 2014-02-05 | 上海微银生物技术有限公司 | Full-automatic phlegm specimen smearing instrument, system and method |
| US20170097289A1 (en) * | 2014-06-30 | 2017-04-06 | Ventana Medical Systems, Inc. | Specimen processing systems, pipette assemblies and methods for preparing reagents |
| CN107957364A (en) * | 2017-11-30 | 2018-04-24 | 珠海贝索生物技术有限公司 | A kind of automatic staining device |
| CN108168986A (en) * | 2018-03-21 | 2018-06-15 | 深圳市鹏医疗仪器有限公司 | Full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine and film-making colouring method |
| CN208790719U (en) * | 2018-08-23 | 2019-04-26 | 达科为（深圳）医疗设备有限公司 | A kind of novel intelligent mounting machine |
| CN210119382U (en) * | 2019-05-15 | 2020-02-28 | 高广锋 | Full-automatic thallus diaphragm preparation system |
-
2019
- 2019-05-15 CN CN201910402602.2A patent/CN111948000A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201255707Y (en) * | 2008-04-23 | 2009-06-10 | 珠海市丽拓发展有限公司 | Cell slide-making staining machine |
| CN201449349U (en) * | 2009-04-24 | 2010-05-05 | 珠海福生医疗器械有限公司 | Automatic liquid based lamina cell smear machine |
| CN103558071A (en) * | 2013-11-08 | 2014-02-05 | 上海微银生物技术有限公司 | Full-automatic phlegm specimen smearing instrument, system and method |
| US20170097289A1 (en) * | 2014-06-30 | 2017-04-06 | Ventana Medical Systems, Inc. | Specimen processing systems, pipette assemblies and methods for preparing reagents |
| CN107957364A (en) * | 2017-11-30 | 2018-04-24 | 珠海贝索生物技术有限公司 | A kind of automatic staining device |
| CN108168986A (en) * | 2018-03-21 | 2018-06-15 | 深圳市鹏医疗仪器有限公司 | Full-automatic liquid-based cell sample manufacturing dyeing all-in-one machine and film-making colouring method |
| CN208790719U (en) * | 2018-08-23 | 2019-04-26 | 达科为（深圳）医疗设备有限公司 | A kind of novel intelligent mounting machine |
| CN210119382U (en) * | 2019-05-15 | 2020-02-28 | 高广锋 | Full-automatic thallus diaphragm preparation system |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113777288A (en) * | 2021-09-14 | 2021-12-10 | 中国人民解放军总医院第八医学中心 | Mycobacterium tuberculosis automatic check out test set |
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