CN111938708B - Mask and method capable of collecting spray samples - Google Patents
Mask and method capable of collecting spray samples Download PDFInfo
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- CN111938708B CN111938708B CN202010628002.0A CN202010628002A CN111938708B CN 111938708 B CN111938708 B CN 111938708B CN 202010628002 A CN202010628002 A CN 202010628002A CN 111938708 B CN111938708 B CN 111938708B
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- 239000007921 spray Substances 0.000 title claims abstract description 28
- 238000000034 method Methods 0.000 title abstract description 15
- 230000002209 hydrophobic effect Effects 0.000 claims abstract description 34
- 239000012528 membrane Substances 0.000 claims abstract description 29
- 230000005661 hydrophobic surface Effects 0.000 claims abstract description 12
- 230000029058 respiratory gaseous exchange Effects 0.000 claims description 3
- 238000001514 detection method Methods 0.000 abstract description 17
- 201000010099 disease Diseases 0.000 abstract description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 4
- 244000052616 bacterial pathogen Species 0.000 abstract description 3
- 239000000428 dust Substances 0.000 abstract description 3
- 244000005700 microbiome Species 0.000 abstract description 3
- 210000002345 respiratory system Anatomy 0.000 abstract description 2
- 238000005259 measurement Methods 0.000 abstract 2
- 241000700605 Viruses Species 0.000 description 7
- 238000010586 diagram Methods 0.000 description 6
- 238000001917 fluorescence detection Methods 0.000 description 6
- 208000018569 Respiratory Tract disease Diseases 0.000 description 5
- 150000007523 nucleic acids Chemical class 0.000 description 5
- 102000039446 nucleic acids Human genes 0.000 description 5
- 108020004707 nucleic acids Proteins 0.000 description 5
- 208000023504 respiratory system disease Diseases 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 2
- 238000012408 PCR amplification Methods 0.000 description 2
- 238000007405 data analysis Methods 0.000 description 2
- 230000002255 enzymatic effect Effects 0.000 description 2
- 238000011901 isothermal amplification Methods 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 208000025721 COVID-19 Diseases 0.000 description 1
- 241000606161 Chlamydia Species 0.000 description 1
- 241001647372 Chlamydia pneumoniae Species 0.000 description 1
- 241000712431 Influenza A virus Species 0.000 description 1
- 241000713196 Influenza B virus Species 0.000 description 1
- 241000589242 Legionella pneumophila Species 0.000 description 1
- 241000204031 Mycoplasma Species 0.000 description 1
- 241000202934 Mycoplasma pneumoniae Species 0.000 description 1
- 208000002606 Paramyxoviridae Infections Diseases 0.000 description 1
- 241000711902 Pneumovirus Species 0.000 description 1
- 241000725643 Respiratory syncytial virus Species 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000012295 chemical reaction liquid Substances 0.000 description 1
- 238000004880 explosion Methods 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 229940115932 legionella pneumophila Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 238000002636 symptomatic treatment Methods 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
- A61B10/0051—Devices for taking samples of body liquids for taking saliva or sputum samples
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/24—Methods of sampling, or inoculating or spreading a sample; Methods of physically isolating an intact microorganisms
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The invention belongs to the technical field of masks, and particularly discloses a mask and a method capable of collecting spray samples, wherein the mask comprises a mask body, hanging ropes on two sides of the mask body and a breather valve on the mask body, and the breather valve comprises a frame, a hydrophobic membrane arranged in the frame and a microfluidic chip communicated with the hydrophobic membrane through a flow guide pipe; the hydrophobic surface of the hydrophobic membrane faces the inner side or the outer side of the mask, in the inner time measurement, the spray samples exhaled by the wearer can be collected to detect the related diseases of the respiratory tract, and in the outer time measurement, the spray samples in the air can be collected to detect harmful dust, germs and microorganisms in the air when the wearer inhales; the method is characterized in that the mask is used for collecting samples, and the method is simple in sample collection mode, simple and convenient to operate in subsequent detection, low in cost, easy to carry and capable of being widely applied to daily life.
Description
Technical Field
The invention belongs to the technical field of masks, and particularly relates to a mask and a method capable of collecting spray samples.
Background
Respiratory diseases are one of the most common clinical diseases, can be caused by various pathogens such as viruses, bacteria, chlamydia, mycoplasma and the like, and wearing a mask is one of the effective ways for isolating the disease sources, so that most of respiratory diseases caused by the transmission of spray can be well isolated, but not in a percentage, once the respiratory diseases are transmitted, virus samples can be rapidly collected and the sources and the types of the viruses can be detected for further symptomatic treatment, and for a wearer, the mask is a direct source for contacting the viruses, and the spray samples exhaled by the patient and the spray samples in the inhaled air can be taken as detection bases, but the current mask has no function of collecting the spray samples.
Disclosure of Invention
In order to solve the problems, the invention provides a mask capable of collecting a spray sample, which has the advantages of simple sample collecting process, easy operation, simple and easy subsequent detection, and difficult influence of organism immunity level on detection results, and comprises a mask body, hanging ropes on two sides of the mask body and a breather valve on the mask body, wherein the breather valve comprises a frame, a hydrophobic membrane arranged in the frame and a microfluidic chip communicated with the hydrophobic membrane through a flow guide pipe; the hydrophobic surface of the hydrophobic membrane faces the inner side or the outer side of the mask.
As a further explanation of the above scheme, 2 breathing valves on the mask body are provided, namely an exhalation valve and an inhalation valve, and the hydrophobic surface of the hydrophobic membrane in the frame of the exhalation valve faces the inner side of the mask; the hydrophobic surface of the hydrophobic membrane in the air suction valve frame faces to the outer side of the mask.
As a further explanation of the scheme, the breather valve is detachably matched with the cover body, and the hydrophobic membrane is detachably communicated with the microfluidic chip.
As a further explanation of the above scheme, the frame comprises an upper frame and a lower frame, which are detachably engaged in a snap-fit or screw-thread manner.
The invention also provides a method for collecting respiratory tract disease samples, which comprises the following steps:
the first step: taking a mask with a breather valve, and installing a hydrophobic membrane and a microfluidic chip communicated with the hydrophobic membrane in the breather valve, wherein the hydrophobic surface of the hydrophobic membrane faces the inner side of the mask;
And a second step of: after wearing the mask for a certain time, a person to be collected takes out the microfluidic chip which is communicated with the hydrophobic membrane in the frame of the breathing valve frame, and the microfluidic chip collects droplet liquid, namely a droplet sample;
And a third step of: and adding a reaction solution into the microfluidic chip with the collected samples for detection, wherein the detection method adopts one of PCR digital fluorescence detection or isothermal amplification digital fluorescence detection or enzymatic specific reaction.
The invention has the beneficial effects that:
The invention provides a mask capable of collecting spray samples, wherein a hydrophobic membrane is arranged in a breather valve of the mask, and when the hydrophobic surface of the hydrophobic membrane faces the inner side of the mask, the spray samples exhaled by a wearer can be collected and used for detecting respiratory tract related diseases; when the hydrophobic surface of the hydrophobic membrane faces the outer side of the mask, a spray sample in the air can be collected when a wearer inhales, the mask can be used for detecting harmful dust, germs and microorganisms in the air, and the mask can be carried at any time and collected at any time, and the collection of the sample is simple and convenient; the collected spray sample is guided into a microfluidic chip which is communicated with the hydrophobic membrane through a guide pipe, and the reaction liquid can be directly added into the microfluidic chip to detect the sample, so that the detection of the subsequent sample is more convenient and easy to operate; in the invention, the breather valve is detachably matched with the cover body, the hydrophobic film is detachably communicated with the microfluidic chip, and the upper frame and the lower frame of the breather valve are detachably matched in a buckle type or screw type, so that the breather valve can be replaced, and the resource waste is prevented.
The invention also provides a method for collecting respiratory tract disease samples, which utilizes a mask with a hydrophobic film and a microfluidic chip to collect respiratory tract disease samples or spray samples in the air at fixed time and fixed points, has convenient operation and low cost, and can directly observe and obtain detection results by using a mobile phone or under a microscope only by adding a reaction solution in later sample detection.
Drawings
Fig. 1: according to the mask, an appearance structure schematic diagram of the mask capable of collecting a spray sample is provided;
Fig. 2: the mask top view section structure schematic diagram capable of collecting spray samples is provided;
fig. 3: the mask explosion structure schematic diagram capable of collecting spray samples is provided;
fig. 4: the collection block schematic diagram of the microfluidic chip of the invention;
Fig. 5: the invention relates to a schematic diagram of a PCR digital fluorescence detection method for an acquired sample.
Reference numerals illustrate:
1-hydrophobic membrane 1, 2-cover body 2, 3-micro-fluidic chip 3, 4-breather valve 4, 5-hanging rope 5, 6-flow guiding pipe 6, 7-frame 7, (a) sampling of spray in exhaled gas, (b) sampling of spray in inhaled gas;
(1) a reaction solution containing a nucleic acid sample, (2) preparation of microdroplets, (3) PCR amplification, and (4) data analysis.
Detailed Description
In order to make the solution of the present invention more clear, the present invention will be further described with reference to the drawings and embodiments.
Example 1:
Referring to fig. 1-3, the present embodiment provides a mask capable of collecting a droplet sample, comprising a mask body 2, hanging ropes 5 on two sides of the mask body 2, and a breather valve 4 on the mask body 2, wherein the breather valve 4 comprises a frame 7, a hydrophobic membrane 1 arranged inside the frame 7, and a microfluidic chip 3 communicated with the hydrophobic membrane 1 through a flow guide pipe 6; 2 breather valves 4 on the mask body 2 are respectively an exhalation valve and an inhalation valve, and the hydrophobic surface of the hydrophobic film 1 in the exhalation valve frame 7 faces the inner side of the mask; the hydrophobic surface of the hydrophobic membrane 1 in the suction valve frame 7 faces the outer side of the mask.
When the mask is used, a person wearing the mask faces the inner side of the mask to the mouth and nose of the person wearing the mask, and as the hydrophobic membrane 1 has the characteristic of allowing air to pass but not allowing aerosol with virus and bacteria to pass, when the person exhaling, a spray sample (a process in fig. 3) of the person exhaling can be collected, and the mask can be used for detecting respiratory diseases of the person wearing the mask; during the inspiration, a spray sample in the air can be collected (the process b in fig. 3) and can be used for detecting harmful dust, germs and microorganisms in the air; the collected spray samples are respectively led into the corresponding conducted microfluidic chips 3 through the flow guide pipes 6 by the hydrophobic films 1, and as the collection blocks (figure 4) are arranged in the microfluidic chips 3, the reaction solution can be directly added into the collection blocks of the microfluidic chips 3 during detection, and finally relevant detection results can be obtained by utilizing a mobile phone or observing under a microscope.
Example 2:
Referring to fig. 3, based on embodiment 1, the mask capable of collecting spray samples provided by the invention has the advantages that the breather valve 4 is detachably matched with the mask body 2, the hydrophobic film 1 is detachably connected with the microfluidic chip 3, the frame 7 of the breather valve 4 comprises an upper frame 7 and a lower frame 7, the upper frame 7 and the lower frame 7 are detachably matched, such as a buckle type or a screw type, so that the breather valve 4 can be directly detached when the samples are detected in the later stage, the frame 7 of the breather valve 4 is detached, the microfluidic chip 3 connected with the hydrophobic film 1 is detached for standby, the mask body 2 after the breather valve 4 is detached, and in addition, if the sample detection result is not chigged, the breather valve 4 can be replaced with a new one for recycling.
When the mask in the embodiment 1 or the embodiment 2 is adopted to collect respiratory tract disease samples, one of PCR digital fluorescence detection or isothermal amplification digital fluorescence detection or enzymatic specific reaction can be adopted as a detection method according to detection requirements, wherein the detection content of the incoming and outgoing gas mainly comprises COVID-19 pneumoviruses, influenza A viruses, influenza B viruses, parainfluenza viruses, adenoviruses and respiratory syncytial viruses by taking the PCR digital fluorescence detection method as an example; legionella pneumophila; chlamydia pneumoniae, mycoplasma pneumoniae, and the like; since the microfluidic chip 3 has a collection block (the structure is shown in fig. 4), the nucleic acid reaction solution containing the specific virus is subjected to microdroplet treatment, i.e., the reaction system containing the nucleic acid molecules is divided into thousands of nano-scaled microdroplets, wherein each microdroplet contains no nucleic acid target molecule to be detected or one or more nucleic acid target molecules to be detected, then, after PCR amplification, specific data analysis is performed, and finally, the relevant detection result can be obtained by observing the microdroplet under a mobile phone or a microscope, and the process schematic diagram is shown in fig. 5.
The mask capable of collecting respiratory tract disease samples provided in embodiments 1-2 has the advantages of simple sample collecting mode, simple and convenient subsequent detection, easy operation, low cost and portability, and can be widely applied to daily life.
The foregoing description is only illustrative of the present invention and is not intended to limit the scope of the invention, and all equivalent structures or equivalent processes or direct or indirect application in other related technical fields are included in the scope of the present invention.
Claims (3)
1. The mask capable of collecting the spray samples comprises a mask body, hanging ropes on two sides of the mask body and a breather valve on the mask body, and is characterized in that the breather valve comprises a frame, a hydrophobic membrane and a microfluidic chip, wherein the hydrophobic membrane is arranged in the frame, and the microfluidic chip is communicated with the hydrophobic membrane through a flow guide pipe; the hydrophobic surface of the hydrophobic membrane faces the inner side or the outer side of the mask, 2 breathing valves on the mask body are respectively an exhalation valve and an inhalation valve, and the hydrophobic surface of the hydrophobic membrane in the exhalation valve frame faces the inner side of the mask; the hydrophobic surface of the hydrophobic membrane in the air suction valve frame faces to the outer side of the mask.
2. The mask capable of collecting spray samples according to claim 1, wherein the breather valve is detachably matched with the mask body, and the hydrophobic membrane is detachably communicated with the microfluidic chip.
3. A mask capable of collecting a spray sample as claimed in claim 1 or claim 2, wherein the frame comprises an upper frame and a lower frame, said upper and lower frames being detachably engaged in a snap-fit or screw-threaded manner.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010628002.0A CN111938708B (en) | 2020-07-02 | 2020-07-02 | Mask and method capable of collecting spray samples |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010628002.0A CN111938708B (en) | 2020-07-02 | 2020-07-02 | Mask and method capable of collecting spray samples |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN111938708A CN111938708A (en) | 2020-11-17 |
| CN111938708B true CN111938708B (en) | 2024-05-31 |
Family
ID=73337821
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010628002.0A Active CN111938708B (en) | 2020-07-02 | 2020-07-02 | Mask and method capable of collecting spray samples |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111938708B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113288223B (en) * | 2021-04-21 | 2023-09-08 | 安徽福贸生物科技有限公司 | Sampling device for detecting novel coronavirus |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004102179A1 (en) * | 2003-05-01 | 2004-11-25 | Southeast University | Equipment and method for collecting trace substances in the air |
| JP2010220712A (en) * | 2009-03-23 | 2010-10-07 | Kyaribaa International Corporation:Kk | Virus intercepting mask |
| CN102175493A (en) * | 2011-01-18 | 2011-09-07 | 北京大学 | Expiratory air sampling box and method |
| CN108588285A (en) * | 2018-05-14 | 2018-09-28 | 南京岚煜生物科技有限公司 | Kit and its application method based on micro-fluidic chip detection rhinovirus, Respiratory Syncytial Virus(RSV) and parainfluenza virus |
| CN110702666A (en) * | 2019-10-25 | 2020-01-17 | 北京农业智能装备技术研究中心 | System and method for detecting trace heavy metals in air |
| CN210445776U (en) * | 2020-02-29 | 2020-05-05 | 首都医科大学宣武医院 | Mask for sampling pathogen of coronavirus pneumonia |
| CN111307794A (en) * | 2020-03-30 | 2020-06-19 | 上海舒爽材料科技有限公司 | Mouth-operated oral cavity detection mechanism and corresponding intelligent oral cavity detector |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20180242884A1 (en) * | 2017-02-15 | 2018-08-30 | Northeastern University | Sorptive Tab Device for Breath Collection and Analysis |
-
2020
- 2020-07-02 CN CN202010628002.0A patent/CN111938708B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004102179A1 (en) * | 2003-05-01 | 2004-11-25 | Southeast University | Equipment and method for collecting trace substances in the air |
| JP2010220712A (en) * | 2009-03-23 | 2010-10-07 | Kyaribaa International Corporation:Kk | Virus intercepting mask |
| CN102175493A (en) * | 2011-01-18 | 2011-09-07 | 北京大学 | Expiratory air sampling box and method |
| CN108588285A (en) * | 2018-05-14 | 2018-09-28 | 南京岚煜生物科技有限公司 | Kit and its application method based on micro-fluidic chip detection rhinovirus, Respiratory Syncytial Virus(RSV) and parainfluenza virus |
| CN110702666A (en) * | 2019-10-25 | 2020-01-17 | 北京农业智能装备技术研究中心 | System and method for detecting trace heavy metals in air |
| CN210445776U (en) * | 2020-02-29 | 2020-05-05 | 首都医科大学宣武医院 | Mask for sampling pathogen of coronavirus pneumonia |
| CN111307794A (en) * | 2020-03-30 | 2020-06-19 | 上海舒爽材料科技有限公司 | Mouth-operated oral cavity detection mechanism and corresponding intelligent oral cavity detector |
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| Publication number | Publication date |
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| CN111938708A (en) | 2020-11-17 |
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