CN111919972A - Production method of feed additive for preventing and controlling African swine fever - Google Patents

Production method of feed additive for preventing and controlling African swine fever Download PDF

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CN111919972A
CN111919972A CN201910351162.2A CN201910351162A CN111919972A CN 111919972 A CN111919972 A CN 111919972A CN 201910351162 A CN201910351162 A CN 201910351162A CN 111919972 A CN111919972 A CN 111919972A
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raw materials
salt
parts
starch
feed additive
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雷志刚
文利新
雷星宇
蒋政云
岳腊梅
朱丽娟
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Changsha Lvye Biotechnology Co ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/195—Antibiotics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/20—Inorganic substances, e.g. oligoelements
    • A23K20/22—Compounds of alkali metals
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/20—Inorganic substances, e.g. oligoelements
    • A23K20/24—Compounds of alkaline earth metals, e.g. magnesium
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/20—Inorganic substances, e.g. oligoelements
    • A23K20/30—Oligoelements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/38—Silver; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses

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Abstract

A feed additive for preventing and controlling African swine fever is prepared from the raw materials including soluble inorganic salt with antibacterial function, powdered salt with solubility less than or equal to 100 meshes and edible gum or starch through preparing raw materials, grinding, gelatinizing, puffing, granulating, coating film, inspecting and packing. The method is simple and scientific, raw materials are easy to purchase, the produced additive has resistance (no vaccine exists for ASFV) which cannot be solved by the existing antibiotics, has excellent broad spectrum, has stronger inactivation activity on viruses and bacteria, has excellent safety, LD50 is more than or equal to 5000, belongs to nontoxic grade, and can supplement beneficial trace elements such as copper, zinc, iron, magnesium, potassium, calcium and the like in feed.

Description

Production method of feed additive for preventing and controlling African swine fever
Technical Field
The invention relates to a production method of a feed additive for preventing and controlling African swine fever, and belongs to the technical field of feed additives.
Background
African swine fever, called ASFV for short, was first reported in Kenney from 1909, always existed in African countries in the south of Sahara, and was first handed over to Western Europe and Lamei in 1975, most of which were put out in time, but southwest grapevine and Italian Saodin island still have popularity. Since 2007, ASFV has occurred, spread, and prevailed in many countries around the world, particularly Russia and surrounding areas. In 2017, in 3 months, ASFV epidemic situation occurs in Eakzkchoi in the far east Russia, and it is a great concern that the distance from the epidemic disease occurrence region to China is only about 1000 km;
china is a big country for raising pigs and pork consumption, the marketing amount, the stocking amount and the pork consumption amount of live pigs are all in the top of the world, the total import amount of the pigs and pork products is huge every year, the trade with a plurality of countries is frequent, and the number of commodities carried by passengers is large and the types are mixed. Therefore, the risk of the introduction of the AFS into China is increasing, once the AFS is introduced, the direct and indirect losses caused by the AFS are immeasurable, and for this reason, the ministry of agriculture in China issues an emergency notice about further strengthening the work of risk prevention of African Swine Fever (ASFV) in 12 months in 2017;
as proved by Chinese animal hygiene and epidemic diagnosis in China at 17 pm on 8/2/2018, suspected ASFV epidemic situation occurs in new areas in Shenyang north, and the diagnosis is confirmed at 11 am on 3/8/15/8, 913 pigs in the epidemic spot are all killed and harmlessly treated. Until 4 months and 4 days in 2019, only Hainan Tibet in China has no ASFV report yet;
according to the report of the new Beijing report of 3.27.2019, due to the complexity of the ASFV structure, experts at home and abroad agree that the ASFV vaccine research and development needs at least 8 years, and meanwhile, livestock medical prevention experts in Japan and other countries consider that a series of problems of ASFV strain variability and vaccine residue in meat and the like are rather complicated problems. Therefore, although the occurrence of ASFV has been in the past 110 years, the current methods used by people are not only harmless treatment by killing, but also no effective preventive or therapeutic drugs or foods;
in particular, in 26 months 3 and 2019, the other concern is raised by experts in the prevention and control center of animal epidemic diseases on the international forum for vaccine innovation: the epidemic flow concept considers that the ASFV only infects pigs, but the latest research of the university in China indicates that the 'body shadow' of the ASFV can be found on cattle and sheep at least on the molecular level; meanwhile, the researchers of Chinese who have been engaged in the research of inorganic sterilization materials for a long time propose: at present, the vegetation is abundant all over the country, the natural ecology is recovered very well, the wild boar breeding is rapidly increased, and particularly, the fluidity and the uncontrollable property of the wild boar bring a very unfavorable situation to the ASFV transmission, so the rigor of the epidemic prevention situation is not imaginable;
because the existing antibiotics have no obvious inactivation effect on ASFV, all inorganic bactericides with resistance become the first choice of the invention, and the problems of uniform addition, antagonism and oxidation of the inorganic bactericides in pig feed are successfully solved through tests of nearly several months, and especially the problems of broad spectrum, functionality, safety and economy of the technical product are fundamentally solved, so that the method has positive significance for ensuring the quality safety and quantity safety of meat food supply in China and the economic benefit of farmers.
Disclosure of Invention
The invention aims to provide a method for producing a feed additive for preventing and controlling African swine fever, which is used for providing an optimal method for producing the feed additive for preventing and controlling African swine fever, so as to solve the problems that the existing antibiotics have no obvious inactivation effect and resistance to ASFV and the problems of antagonistic oxidation and difficult dispersion stability caused by adding inorganic bactericides in feeding.
In order to solve the technical problems, the inventor applies the staged success of the technology of the nano material 863 to the field of livestock breeding by combining the characteristics of livestock breeding and through a plurality of months of extensive experiments in the research and development process of inorganic bactericides for nearly twenty years, successfully solves the technical problems of resistance, economy, safety and durability, and summarizes a set of method for producing the feed additive for preventing and controlling the African swine fever. The additive is added into pig feed for daily feeding while strictly sterilizing and disinfecting a live pig farm, so that the African swine fever can be prevented and treated.
The production method of the feed additive for preventing and controlling African swine fever comprises the following steps:
Figure 100002_DEST_PATH_IMAGE001
preparing materials: the following raw materials are prepared according to parts by weight:
a. soluble inorganic salt with an antibacterial function,
0.5-1.0 part of silver salt, 3-8 parts of copper salt, 5-10 parts of zinc salt, 6-11 parts of cerium salt and 5-10 parts of iron salt;
b. soluble powder salt with the particle size of less than or equal to 100 meshes,
5-10 parts of magnesium salt, 10-20 parts of potassium salt and 20-50 parts of calcium salt;
c. 5-50% of edible glue or starch, wherein the lower limit is selected when high viscose is selected, the upper limit is selected when low viscose is selected, and any mixture of the edible glue and the starch can be selected;
Figure 123417DEST_PATH_IMAGE002
and grinding: stirring and sieving by a medialess grinding mill to 100 meshes, wherein 2-20 parts of edible gum starch is preferably added for the first time in the grinding process, and the edible gum starch mainly plays roles of bonding, dispersing and expanding agent in the edible gum starch;
Figure 100002_DEST_PATH_IMAGE003
and pasting: heating the raw materials to 110-150 ℃ to uniformly gelatinize the raw materials, and then cooling the raw materials to room temperature, wherein the process is preferably sealed to prevent the raw materials from being oxidized;
Figure 1374DEST_PATH_IMAGE004
and puffing and granulating: puffing the above materials until the porosity is greater than 70% and the density is less than or equal to 0.9g/cm2(prevent segregation while batching for the second time), the particle size is controlled to be 0.8-1.0 mm preferably, basically should be the same as most raw materials particle size of the feed basically, prevent segregation from causing the heterogeneity of the active ingredient of the raw materials, wherein the material that is too fine and too coarse returns to gelatinize again for the second time;
Figure 100002_DEST_PATH_IMAGE005
and wrapping and laminating: the particles are further wrapped and coated to prevent the functional components from being oxidized,reducing the sterilization effect, wherein the film forming material is preferably edible film or starch, and the dosage is preferably 3-30 parts of the granulated weight (the rest edible gum or starch after the raw materials are ground, gelatinized and puffed);
Figure 790338DEST_PATH_IMAGE006
and (3) checking: detecting the accuracy of the ingredients: wherein: the silver, the copper, the zinc and the cerium are strictly controlled in a batching range, otherwise, the materials are returned for batching, and other raw materials are marked with relevant detection data of effective content, particle size, moisture and volume weight and are used for reference in material preparation of downstream enterprises;
Figure 100002_DEST_PATH_IMAGE007
and packaging: after the vacuum packaging is qualified, the moisture oxidation and the packaging bag damage are prevented.
Compared with the prior art, the invention has the following substantial characteristics and remarkable progress:
1. one of the unique aspects of the present invention is the step
Figure 141554DEST_PATH_IMAGE003
Pasting: heating the raw materials to 110-150 ℃ to uniformly gelatinize the raw materials, and then cooling the raw materials to room temperature, wherein the process is preferably sealed to prevent the raw materials from being oxidized;
2. the second unique point of the present invention is the step
Figure 383180DEST_PATH_IMAGE004
Puffing and granulating: the raw materials are puffed until the porosity is more than 70 percent and the density is less than or equal to 0.9g/cm2(prevent segregation during the secondary batching), the particle size is preferably controlled at 0.8-1.0 mm, and basically the same as the particle size of most raw materials of the feed, so that the non-uniformity of effective components of the raw materials caused by segregation is prevented. Wherein, the substances which are too fine and too coarse return to secondary gelatinization;
3. the third unique part of the present invention is the steps
Figure 923882DEST_PATH_IMAGE005
Wrapping and laminating: the particles are further wrapped and coated with a film to prevent functional components from being oxidized and reduce the sterilization effect, wherein the film forming material is preferably edible film or starch, and the dosage of the film forming material is preferably 3-30 parts of the weight of the granulated material (the rest edible glue or starch after the material preparation, grinding, pasting and puffing);
4. the fourth unique point of the invention is that the mixture ratio of the raw materials and the priority range are scientific and reasonable:
wherein 1: the silver salt content is 0.5-1.0, preferably 0.6-0.9, when the silver salt is excessive by 1.0, LD50 is less than 5000 (same below the rat calibre) to affect the safety of the product, and when the silver salt is less than 0.5, the antibacterial effect is greatly reduced to affect the function of the product;
wherein 2: the content of the copper salt is 3-8, preferably 3.5-7.5, and when the copper salt is more than 8, the LD50 is less than 5000; when the copper salt is less than 3, the synergistic effect with silver and zinc can be influenced;
wherein 3: the content of the zinc salt is 5-10, preferably 5.5-9.5, when the zinc salt is more than 10, LD50 is less than 5000, and when the zinc salt is less than 5, the synergistic effect of silver and copper is influenced;
wherein 4: the content of the cerium salt is 6-11, preferably 6.5-10.5, when the cerium salt is excessive 11, the cost is increased, and when the cerium salt is less than 5, the wall penetrating capability of the product on microorganisms is influenced;
wherein 5: the content of the ferric salt is 5-10, preferably 5.5-9.5, when the ferric salt is excessive 10, the addition of other raw materials is influenced, and when the ferric salt is less than 5, the pairing of the chemical primary battery, namely the synergistic effect with copper ions, is influenced;
wherein 6: the content of the magnesium salt is 5-10, preferably 5.5-9.5, when the magnesium salt is more than 10, the magnesium salt can not be absorbed by animals, and additives of other elements are also influenced, when the magnesium salt is less than 5, the content of active magnesium ions in the feed is less than 400 mg, so that the animals are unstable and tense;
wherein 7: the content of the potassium salt is 10-20, preferably 10.5-19.5, and when the content of the potassium salt is more than 20, the cell osmotic pressure of livestock can be increased, and the animal can be dead due to low heart rate; when the potassium salt is less than 10, the amount of nutrients to be supplied to the animal and the amount of anion antagonistic antibacterial ions in the feed are not sufficient;
wherein 8: when the content of the calcium salt is more than 50, the addition and the synergistic effect of other elements are influenced, and when the content of the calcium salt is less than 20, the total amount of potassium, calcium and magnesium is reduced, so that the combination number of the calcium salt and anions in the feed is reduced, the residual anions are combined with antibacterial ions, and the antibacterial capability is reduced or even loses effectiveness;
wherein 9: the content of the edible gum active starch is 5-50, preferably 7.5-45, when the edible gum or starch is more than 50%, the addition of other beneficial elements can be reduced, so that the functionality of the edible gum or starch is influenced, when the edible gum or starch is less than 5%, the adhesive and swelling agent capacity of the raw materials is not enough, and when the edible gum or starch is wrapped for the second time, the sealing protective film is not enough;
in a word, compared with the prior art, the method is simple, the raw materials are easy to purchase and have specific range, the produced additive solves the resistance problem of the existing antibiotic (no vaccine exists for ASFV), has excellent broad spectrum, has stronger inactivation activity and excellent safety to viruses and bacteria, LD50 is more than or equal to 5000, belongs to non-toxic grade, has obvious inactivation effect on common escherichia coli, pseudomonas aeruginosa, candida albicans and staphylococcus aureus, has complete inactivation effect on ASFV, and particularly contains beneficial microelements such as zinc, copper, iron, cerium, calcium, magnesium, potassium and the like required by the growth of pigs.
The specific implementation mode is as follows:
the invention is further illustrated below by the following examples:
the first embodiment is as follows: a production method of a feed additive for preventing and controlling African swine fever comprises the following steps:
Figure 567353DEST_PATH_IMAGE008
preparing materials: the following raw materials are prepared according to parts by weight:
a. soluble functional salts, silver salts: copper salt: zinc salt: a cerium salt; the iron salts are respectively: 0.5: 3: 7: 8: 8 parts of a mixture;
b soluble powder salt with the granularity of more than or equal to 100 meshes, magnesium salt: potassium salt: i calcium salt, respectively: according to the following steps: 10: 50 parts of a mixture;
c. 8.5 parts of edible glue or starch (wherein 3.5 parts of edible glue or starch are added for bonding, pasting and expanding for the first time, and 5 parts of edible glue or starch are added for wrapping after granulation for the second time), the edible glue or starch is ground, stirred and sieved by a sieve of 100 meshes, then is uniformly pasted and cooled to room temperature at 110-150 ℃, and then is expanded and granulated until the porosity is more than 70 percent and the density is less than or equal to 0.9g/cm3Controlling the particle size to be 0.8-1.0 mm, finally wrapping and laminating with edible gum or starch, checking to meet each index of 5 parts of design, and warehousing after vacuum packaging by covering with a plastic film;
Figure 168099DEST_PATH_IMAGE002
and grinding: grinding and stirring by using a medialess mill to pass through 100 meshes, wherein 2-20 parts of edible gum starch is added for the first time in the grinding process, and the functions of bonding, dispersing and swelling agent are mainly played in the edible gum starch;
Figure 303545DEST_PATH_IMAGE003
and pasting: heating the raw materials to 110-150 ℃ to uniformly gelatinize the raw materials, and then cooling the raw materials to room temperature, wherein the process is preferably sealed to prevent the raw materials from being oxidized;
Figure 382360DEST_PATH_IMAGE004
and puffing and granulating: puffing the above materials until the porosity is greater than 70% and the density is less than or equal to 0.9g/cm2(prevent segregation while batching for the second time), the particle size is controlled to be 0.8-1.0 mm preferably, basically should be the same as most raw materials particle size of the feed basically, prevent segregation from causing the heterogeneity of the active ingredient of the raw materials, wherein the material that is too fine and too coarse returns to gelatinize again for the second time;
Figure 145916DEST_PATH_IMAGE005
and wrapping and laminating: further wrapping and coating the particlesThe oxidation of functional components is prevented, and the sterilization effect is reduced, wherein the film forming material is edible film or starch, and the using amount of the film forming material is 3-30 parts of the weight of the granulated film or starch (the rest edible glue or starch after the prepared material is ground, gelatinized and puffed);
Figure DEST_PATH_IMAGE009
and (3) checking: detecting the accuracy of the ingredients: wherein: the silver, the copper, the zinc and the cerium are strictly controlled in a batching range, otherwise, the materials are returned for batching, and other raw materials are marked with relevant detection data of effective content, particle size, moisture and volume weight and are used for reference in material preparation of downstream enterprises;
Figure 183143DEST_PATH_IMAGE007
and packaging: after the vacuum packaging is qualified, the moisture oxidation and the packaging bag damage are prevented.
Example two: a method for producing a feed additive for preventing and controlling African swine fever comprises the following steps:
Figure 133781DEST_PATH_IMAGE001
preparing materials: the following raw materials are prepared according to parts by weight:
a. soluble functional salts, silver salts: copper salt: zinc salt: cerium salt: the iron salts are respectively: 1.0: 8: 10: 6: 5 parts of a mixture;
b. soluble powder salt with the particle size of more than or equal to 100 meshes, magnesium salt: potassium salt: the calcium salts are respectively 10: 15: 25;
c. 20 parts of edible glue or starch (wherein 10 parts of the edible glue or starch are used for bonding, pasting and 10 parts of the edible glue or starch are used for wrapping and laminating) are ground, stirred and sieved by 100 meshes, then are uniformly pasted and cooled to room temperature at 110-150 ℃, and are expanded and granulated until the porosity is more than 70%, the density is less than or equal to 0.98/cm3, and the particle size is controlled to be 0.8-1.0 mm. Finally, 10 parts of edible grade or starch is used for wrapping and laminating, all indexes meeting the design are checked, and plastic film is coated for vacuum packaging and then is put in storage; the rest steps are the same as the first embodiment.
Example three: a method for producing a feed additive for preventing and controlling African swine fever comprises the following steps:
Figure 281866DEST_PATH_IMAGE001
preparing materials: the following raw materials are prepared according to parts by weight:
a. soluble functional salts, silver salts: copper salt: zinc salt: cerium salt: the iron salts were 0.7: 5.3: 5: 10: 10 parts of (A);
b. soluble powder salt with the particle size of more than or equal to 100 meshes, magnesium salt: potassium salt: calcium salts were 7.5: 20: 30 parts of (1);
c. 22 parts of edible gum or starch (wherein the first 12 parts are used for bonding, pasting and the second 12 parts are used for coating and coating) are ground, stirred and sieved by 100 meshes, then uniformly pasted and cooled to room temperature at 110-150 ℃, and then expanded and granulated until the porosity is more than 70 percent and the density is less than or equal to 0.98/cm2Controlling the particle size to be 0.8-1.0 mm, finally wrapping and laminating with 10 parts of edible grade or starch, checking to meet various designed indexes, and warehousing after vacuum packaging by covering a plastic film; the rest steps are the same as the first embodiment.
Through the three embodiments, the invention can be verified to have obvious killing effect on common pathogenic bacteria, escherichia coli, pseudomonas aeruginosa, candida albicans and staphylococcus aureus, and has obvious inactivation on African swine fever strains (ASFV) with extremely strong resistance, and particularly, beneficial elements such as zinc, copper, iron, calcium, magnesium, potassium and the like can be supplemented to the feed;
the above detailed description illustrates the essence of the present invention in detail, but should not be construed as limiting the scope of the present invention, and all simple modifications, modifications and equivalents made according to the essence of the present invention fall within the scope of the claims of the present invention.

Claims (4)

1. A production method of a feed additive for preventing and controlling African swine fever is characterized in that: the method comprises the following steps:
Figure DEST_PATH_IMAGE001
preparing materials: the following raw materials are prepared according to parts by weight:
a. soluble inorganic salt with an antibacterial function, 0.5-1.0 part of silver salt, 3-8 parts of copper salt, 5-10 parts of zinc salt, 6-11 parts of cerium salt and 5-10 parts of iron salt;
b. soluble powder salt with the particle size of less than or equal to 100 meshes, 5-10 parts of magnesium salt, 10-20 parts of potassium salt and 20-50 parts of calcium salt;
c. 5-50% of edible glue or starch, wherein the lower limit is selected when high viscose is selected, the upper limit is selected when low viscose is selected, and any mixture of the edible glue and the starch can be selected;
Figure 878948DEST_PATH_IMAGE002
and grinding: stirring and sieving by a medialess grinding mill to 100 meshes, wherein 2-20 parts of edible gum starch is added for the first time in the grinding process, and the functions of bonding, dispersing and bulking agent are mainly played in the edible gum starch;
Figure DEST_PATH_IMAGE003
and pasting: heating the raw materials to 110-150 ℃ to uniformly gelatinize the raw materials, and then cooling the raw materials to room temperature, wherein the process is preferably sealed to prevent the raw materials from being oxidized;
Figure 742868DEST_PATH_IMAGE004
and puffing and granulating: puffing the above materials until the porosity is greater than 70% and the density is less than or equal to 0.9g/cm2(prevent segregation while batching for the second time), the particle size is controlled to be 0.8-1.0 mm preferably, basically should be the same as most raw materials particle size of the feed, prevent segregation from causing the heterogeneity of the active ingredient of the raw materials;
wherein, the substances which are too fine and too coarse return to secondary gelatinization;
Figure DEST_PATH_IMAGE005
and wrapping and laminating: the particles are further coated and covered with a film to prevent the functional components from being oxidized and reduce the sterilization effect, wherein the particles are formedThe film material is preferably edible film or starch, and the dosage is preferably 3-30 parts of the weight after granulation (the rest edible gum or starch after the raw materials are ground, gelatinized and puffed);
Figure 836594DEST_PATH_IMAGE006
and (3) checking: detecting the accuracy of the ingredients: wherein: the silver, the copper, the zinc and the cerium are strictly controlled in a batching range, otherwise, the materials are returned for batching, and other raw materials are marked with relevant detection data of effective content, particle size, moisture and volume weight and are used for reference in material preparation of downstream enterprises;
Figure DEST_PATH_IMAGE007
and packaging: after the vacuum packaging is qualified, the moisture oxidation and the packaging bag damage are prevented.
2. The method for producing the feed additive for preventing and controlling African swine fever according to claim 1, wherein the feed additive comprises the following components: the gelatinization of the obtained material can make the product uniform.
3. The method for producing the feed additive for preventing and controlling African swine fever according to claim 1, wherein the feed additive comprises the following components: the method has the advantages that the puffing and granulating steps are adopted, so that the specific gravity of the additive is close to that of the feed main material, and the segregation and layering of materials with different specific gravities during premixing and batching are avoided.
4. The method for producing the feed additive for preventing and controlling African swine fever according to claim 1, wherein the feed additive comprises the following components: the coating step is adopted, so that the antioxidation of the additive is realized, and the stable performance of the product in the quality guarantee period is ensured.
CN201910351162.2A 2019-04-28 2019-04-28 Production method of feed additive for preventing and controlling African swine fever Pending CN111919972A (en)

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Application publication date: 20201113