CN111904887B - 一种皮肤卫生护理组合物及其在纸尿裤中的应用 - Google Patents
一种皮肤卫生护理组合物及其在纸尿裤中的应用 Download PDFInfo
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Abstract
本发明涉及卫生外用品领域,具体是指一种皮肤卫生护理组合物及其在制备纸尿裤中的应用。一种皮肤卫生护理组合物,包括按重量计的如下组分:酵母菌多肽冻干粉2‑4份,葡萄柚籽提取物1‑3份,蓝莓提取物1‑6份,五香血藤提取物0.5‑8份,白芨粉末1‑2份,透明质酸钠2.5‑4份,乳酸薄荷酯0.1‑1.5份,氢化聚异丁烯0.1‑1.5份。通过该组合物中提取的天然活性物质和酵母菌多肽的的协同作用,可以起到皮肤保湿抗菌消炎等作用,消除或减弱皮肤红肿损伤。由该组合物制备的制剂不仅可以形成皮肤的天然屏障,还可以使***物不易粘附皮肤,显著改善气味,对尿布疹和尿道炎均有预防治疗的作用。
Description
技术领域
本发明涉及卫生外用品领域,具体是指一种皮肤卫生护理组合物及其在制备纸尿裤中的应用。
背景技术
随着人们生活水平的提高,一次性用品的使用越来越普遍,特别是纸尿裤的应用,儿童或成人纸尿裤销量逐年递增,但纸尿裤经常穿脱的过程中包覆层对皮肤的长期摩擦容易造成机械物理损伤,同时由于防渗漏纸尿裤底膜多为有机纤维材料,局部环境温度湿度较高,细菌容易繁殖,特别是尿液,大便中的氨基成分,容易导致皮肤微环境失衡,堵塞,破坏皮肤屏障,婴幼儿表皮更加容易受水合影响,最终导致尿布疹等皮肤伤害,尿布疹是一种婴幼儿常见的皮肤炎性病变,多由尿液浸渍刺激和潮湿环境细菌滋生产生,婴幼儿皮肤脂质层受损加剧局部炎性反应,产生红肿甚至溃烂,更严重引会起细菌感染和普遍性的尿道疾病。
现有技术中通过改善纸尿裤表层透气性或吸收树脂吸水性能,使其干燥柔软导水性增强,来避免皮肤损伤,或者加入护肤成分,PH调节等,例如CN110946712A公开了一种够起到柔臀健脂护理功能的婴幼儿纸尿裤,其中表面包覆层具有面层和导流层,表面包覆层中含有护肤成分;吸收芯层中添加有控制pH值成分,护肤成分含有醇甲酸酯、双甘油、甲灭酸、双胍和芦荟凝胶、维生素E、柠檬酸等,控制PH值和抑制氨成分包括乙醇脂和茶多酚。其主要通过控制PH值来预防皮肤刺激和尿布疹发生。然而改变PH值而加入的酸性成分,可能导致正常皮肤表面PH值改变,在没有尿液和其他***物时使用对皮肤并没有额外的好处;另外,也没有减少***物本身的有害物质和粘附性,并改善气味。婴幼儿皮肤中的含水量相当高,可高达40%,所以婴幼儿皮肤看起来非常稚嫩,角质层含水量低于10%就会发生皮肤病。对外界刺激比较敏感,更需要天然保湿舒敏的护肤产品。
发明内容
为解决上述技术问题,本发明的一个目的是提供一种皮肤卫生护理组合物,通过该组合物中提取的天然活性物质和酵母菌多肽的协同作用,可以起到皮肤保湿抗菌消炎等作用,消除或减弱皮肤红肿损伤。由该组合物制备的制剂不仅可以形成皮肤的天然屏障,还可以使***物不易粘附皮肤,显著改善气味,对尿布疹和尿道炎均有预防治疗的作用。
为了实现上述的目的,本发明采用了以下的技术方案:
一种皮肤卫生护理组合物,包括按重量计的如下组分:酵母菌多肽冻干粉2-4份,葡萄柚提取物1-3份,蓝莓提取物1-6份,五香血藤提取物0.5-8份,白芨粉末1-2份,透明质酸钠2.5-4份,乳酸薄荷酯0.1-1.5份,氢化聚异丁烯0.1-1.5份。
优选,葡萄柚提取物提取工艺为,将清洗干净的葡萄柚皮和种子干燥粉碎成粗粉后,加入5-50倍量的70-95℃热水中,超声提取1-2h,重复3次,提取液合并过滤并浓缩、冷冻干燥得到葡萄柚提取物A组份;将上述过滤沉渣加入质量分数为35-85%的乙醇水溶液中,搅拌静置0.5-1h,过滤后提取滤液,重复三次,合并收集滤液,加热浓缩,烘干,得到葡萄柚提取物B组份,将上述A、B组份混合得到葡萄柚提取物粉末。
优选,蓝莓提取物提取工艺为:取蓝莓果实,充分破碎后用体积分数0.5%HCl和65-85%乙醇水溶液按照质量体积比1:15混合均匀,30℃下超声波辅助提取30min,提取液过滤后合并收集滤液,浓缩,干燥,得蓝莓提取物粉末。
优选,五香血藤提取物通过如下方法制备,洗净五香血藤,干燥后置于粉碎机中进行粉碎处理,碾磨机中充分研磨,加入索氏提取器中,加入乙醇溶液,加热回流0.5-2h,收集乙醇,得到五香血藤提取液体,对其进行喷雾干燥或冷冻干燥,得到五香血藤提取物粉末。
进一步,本申请提供了一种皮肤卫生护理制剂,包括所述的组合物在内的如下组分:酵母菌多肽冻干粉2-4份,葡萄柚提取物1-3份,蓝莓提取物1-6份,五香血藤提取物0.5-8份,白芨粉末1-2份,透明质酸钠2.5-4份,乳酸薄荷酯0.1-1.5份,氢化聚异丁烯0.1-1.5份,氢化卵磷脂0.2-1份,维生素E醋酸酯0.1-2份,氧化锌0.5-1份,麻油1.5-10份,甘草酸二钾0.1-1份,表面活性剂0.1-2份,防腐剂0.1-0.2份,去离子水2-9份。
优选,该制剂的制备方法如下:
1)将上述重量份乳酸薄荷酯、氢化聚异丁烯、氢化卵磷脂、维生素E醋酸酯、麻油依次投入乳化锅中,混合均匀后投入氧化锌,60-80℃条件下搅拌15-45分钟,得到A组份混合;
2)将表面活性剂与透明质酸钠加入去离子水中加热至60-90℃搅拌,混合或依次加入白芨粉、五香血藤提取物粉末、葡萄柚提取物粉末、蓝提取物粉末,搅拌15-30分钟,加入甘草酸二钾,搅拌均匀得到B组份混合;
3)保温条件下将B组份加入A组分乳化锅中,乳化锅底部均质转速1500转/分钟,乳化锅内刮板速度30转/分钟,温度60-90℃,搅拌10-50分钟,自然降温达室温后将酵母菌多肽冻干粉、防腐剂依次加入到乳化锅中,继续搅拌20分钟,混合均匀即得。
优选,所述表面活性剂选自十二烷基甜菜碱,鲸蜡硬脂基葡糖苷、甘油硬脂酸酯中的一种或多种。
优选,该组合物可制备为凝胶剂、喷雾剂、乳剂、霜剂或膏剂形式,直接涂抹于皮肤表面或纸尿裤表层底部。
进一步,本申请提供了一种护肤抗菌纸尿裤的透液表层,该表层为无纺布材料或天然纤维材料,并含有所述组合物。
进一步,本申请提供了一种护肤抗菌纸尿裤的透液表层的制备方法,使用无纺布材料或天然纤维材料,并通过如下方法制成,葡萄柚提取物1-3份,蓝莓提取物1-6份,五香血藤提取物0.5-8份,各自洗净干燥粉碎碾磨后,混合加入5-50倍量乙醇,搅拌加入白芨粉末0.5-1份,上述混合物在40-80℃条件下超声0.5-1h,静置后回收乙醇得到植物提取物,加入透明质酸钠2.5-4份,乳酸薄荷酯0.1-1.5份,氢化聚异丁烯0.1-1.5份,加入去离子水搅拌混合均匀,得到药物溶液,使用浸渍法,将无纺布材料或天然纤维材料浸入上述溶液中,轧液率为30-40%,温度25-45℃,处理0.5-1h后紫外线消毒,酵母菌多肽冻干粉1-3份溶于去离子水中,浓度0.5g/100ml,均匀喷洒后,低温干燥定型,得到纸尿裤透液表层。
本申请中植物提取物可以按常规工艺制备或购买市售产品,优选以上述工艺制备。其中,蓝莓提取物含有大量原花青素物质,不仅抗细菌黏附,还能阻止大肠杆菌等致病菌黏附在尿道的上皮细胞和膀胱壁上,致病菌随着尿液流走,从而预防了尿道感染的发生。众所周知葡萄柚能够滋养组织细胞,利尿消肿、抗菌抗感染、调理混合型、油性等容易长痘痘的肌肤,深层净化油性暗疮和充血的皮肤,促进毛发生长和紧实皮肤跟组织,葡萄柚提取物中含有的柚皮苷具有抗炎镇痛、抗病毒和抑菌等作用。五香血藤提取物具有消肿祛湿和抗菌的作用。白芨性微寒,味苦涩,入肺经,具有收敛止血、补肺生肌的作用,可以消肿生肌,用于痈疽疮毒及水火烫伤。
酵母菌多肽作为保湿剂、抗衰老原料多用于护肤品中,本发明发现酵母菌多肽应用于婴幼儿纸尿裤尿布疹防护中,可以显著改善***物味道,并且降低了皮肤对***物的敏感性,和上述植物提取物合用尿布疹发生率降低。
本发明的有益效果为:上述天然物质组合使用,不仅在皮肤表层形成了天然的保护屏障,温和隔离***物,还能够抵抗抑制细菌和病毒,有效预防和治疗尿布疹、尿道炎等疾病,同时消除和改善***物的臭味。在植物提取物中,葡萄柚和蓝莓均含有抗菌成分,能够较大程度抑制病菌感染,且消炎镇痛的效果好,五香血藤含有抗菌成分的同时也能起到舒缓皮肤红肿的作用,而白芨既能消肿生肌还能提高多肽物质的稳定性,酵母菌多肽显著改善了***物味道并协同增强植物提取物抗菌作用,没有刺激性和皮肤敏感性。该组合物制备的制剂用于纸尿裤表层整体后,尿布疹及其并发症概率显著降低,皮肤***物黏附的情况减少,臭味削弱甚至消失,使得皮肤更容易保持干净清爽。而透明质酸钠作为皮肤的天然保湿因子之一,保湿吸水抗静电,乳酸薄荷酯使用后具有皮肤清凉感,氢化聚异丁烯也称为鲨鱼油,具有皮肤亲脂性。甘草酸二钾具有抑菌、消炎、解毒、抗敏、除臭等多种功效。在医药、化妆品日化、食品等行业有广泛的应用。以上述辅料制备的皮肤卫生护理制剂,作为护肤保健产品易于涂展,温和隔离。
具体实施方式
下面通过具体实施例对本发明做进一步说明。
实施例1原料提取物制备
本发明植物提取物可以采用市售原料或通过常规方法制备,优选以如下工艺制备:将清洗干净的葡萄柚皮和种子干燥粉碎成粗粉后,加入5-50倍量的70-95℃热水中,超声提取1-2h,重复3次,提取液合并过滤并浓缩、冷冻干燥得到葡萄柚提取物A组份;将上述过滤沉渣加入质量分数为35-85%的乙醇水溶液中,搅拌静置0.5-1h,过滤后提取滤液,重复三次,合并收集滤液,加热浓缩,烘干,得到葡萄柚提取物B组份,将上述A、B组份混合得到葡萄柚提取物粉末。取蓝莓果实,充分破碎后用体积分数0.5%HCl和65-85%乙醇水溶液按照质量体积比1:15混合均匀,30℃下超声波辅助提取30min,提取液过滤后合并收集滤液,浓缩,干燥,得蓝莓提取物粉末。洗净五香血藤,干燥后置于粉碎机中进行粉碎处理,碾磨机中充分研磨,加入索氏提取器中,加入乙醇溶液,加热回流0.5-2h,收集乙醇,得到五香血藤提取液体,对其进行喷雾干燥或冷冻干燥,得到五香血藤提取物粉末。
酵母菌多肽购自广东金宝莱生物科技公司,通过常规工艺冻干而成,例如,选择纯净水、去离子水、渗透水和蒸馏水等将酵母菌多肽调节至浓度为的多肽溶液;利用高速分散均质机均质化处理,调控转速为/>处理时间为/>获得均质化溶液,转移到冷冻盘中进行预冻,预冻温度为/>预冻时间为/>然后再置于真空冷冻干燥机冷冻仓内,控制真空度小于l0Pa,真空冷冻干燥时间为/>即可获得酵母菌多肽冻干粉。
实施例2分别制备溶液、凝胶剂和乳剂
溶液制备:取酵母菌多肽冻干粉3g,葡萄柚提取物粉末2g,蓝莓提取物粉末4g,五香血藤提取物粉末4g,白芨粉末1g,透明质酸钠3g,乳酸薄荷酯0.7g,氢化聚异丁烯0.7g。将上述植物提取物和多肽冻干粉加入有机相:水相为20:80-40:60的混合溶液中,其中有机相为乙醇或丙酮,水相为去离子水或蒸馏水,搅拌得到混合溶液。
凝胶剂制备:将上述混合溶液加入透明壳聚糖水凝胶或海藻酸钠水凝胶中,摇床摇动,加入甘草酸二钾0.7g,防腐剂0.1g,即得组合物的水凝胶制剂。
实施例3安全性测试
本发明实施例所述皮肤卫生护理组合物制备的水凝胶/乳液和溶液制剂分别测试,对照组用温水。使用幼小白鼠30只,分成三组,健康符合试验要求。分别对水凝胶/乳液和溶液制剂进行测试,采用自体左右侧脱毛皮肤进行对照和试验,对照侧仅使用温水涂抹,将制剂涂抹于另一侧脱毛皮肤每天涂抹一次,12h后清洗,继续涂抹,连续7天。观察结果。
结果显示,所有实验小白鼠没有皮肤过敏应激反应,没有毒性不适反应,生理活动表现均正常,该组合物制备的制剂并无皮肤刺激性和毒性。
实施例4护肤抗菌纸尿裤的透液表层的制备
使用无纺布材料,取葡萄柚皮和种子5g,蓝莓5g,五香血藤8g,各自洗净干燥粉碎碾磨后,混合加入500毫升60%乙醇,搅拌加入白芨粉末2g,上述混合物70℃条件下超声0.5h,静置后回收乙醇得到植物提取物,加入透明质酸钠4g,乳酸薄荷酯1.5g,氢化聚异丁烯1.5g,加入去离子水直至搅拌混合均匀,得到药物溶液,使用浸渍法,将无纺布材料或天然纤维材料浸入上述溶液中,轧液率为35%,温度35℃,处理0.5h后紫外线消毒,酵母菌多肽冻干粉4g份溶于去离子水中,浓度0.5g/100ml,均匀喷洒后,低温干燥定型,得到纸尿裤透液表层。
实施例5抗菌测试
实验组1:将实施例4制备的含由本发明制剂的透液表层分别剪至10*10cm方片,倾倒生理盐水20mL,待其完全吸收后置于封闭环境(37℃,相对湿度为75%),在所述的封闭环境中放置敞口培养的大肠杆菌培养物和链球菌培养物。
实验组2:无纺布材料剪至10*10cm方片,涂抹实施例2制备的乳剂,倾倒生理盐水20mL,待其完全吸收后置于封闭环境(37℃,相对湿度为75%),在所述的封闭环境中放置敞口培养的大肠杆菌培养物和链球菌培养物。
实验组3:无纺布材料剪至10*10cm方片,涂抹实施例2制备的水凝胶,倾倒生理盐水20mL,待其完全吸收后置于封闭环境(37℃,相对湿度为75%),在所述的封闭环境中放置敞口培养的大肠杆菌培养物和链球菌培养物。
实验组4:无纺布材料剪至10*10cm方片,涂抹以实施例2方法制备的乳剂,但其中不含有酵母菌多肽冻干粉,倾倒生理盐水20mL,待其完全吸收后置于封闭环境(37℃,相对湿度为75%),在所述的封闭环境中放置敞口培养的大肠杆菌培养物和链球菌培养物。
实验组5:无纺布材料剪至10*10cm方片,涂抹以实施例2制备的乳剂,但其中不含有添加五香血藤提取物、葡萄柚提取物、蓝莓提取物的步骤,倾倒生理盐水20mL,待其完全吸收后置于封闭环境(37℃,相对湿度为75%),在所述的封闭环境中放置敞口培养的大肠杆菌培养物和链球菌培养物。
对照组:无纺布材料剪至10*10cm方片,倾倒生理盐水20mL,待其完全吸收后置于封闭环境(37℃,相对湿度为75%),在所述的封闭环境中放置敞口培养的大肠杆菌培养物和链球菌培养物。
将上述实验组对照组分别在放置20min、3h、7h后,测量实验组和对照组纸尿裤上的菌落数(CFU/mL),具体测量方法是将无纺布材料剪碎后分散在50mL的去离子水中,浸泡过滤,取1mL试样在温箱中(37℃)培养48h,进行菌落总数测定,测试5批次取平均值。测试结果如表1所示
可见,随着时间的增长,实验组中由组合物制备的溶液/乳剂/凝胶剂制剂抗菌性能逐渐显现,而对照组不仅抗菌性能差,而且随着时间的增长,菌落数增加,其中乳剂组抑菌效果最好,另外实验组4和5证明了各成分具有协同作用,酵母菌多肽和植物提取物的组合使用才能最大程度的发挥药效,使本发明制得的纸尿裤和制剂具有良好的抗菌杀菌性能。
实施例6除臭效果
取相同品牌纸尿裤,剪至15*15cm的方片,放入密封盒中固定,分为两大组,一组纸尿裤上全部涂抹本发明实施例2制备的乳剂,提取物组为以实施例2方法制备的乳剂,但其中不含酵母菌多肽;酵母菌多肽组为实施例2方法制备的乳剂但其中不含添加五香血藤提取物、葡萄柚提取物、蓝莓提取物的步骤,另一空白组没有涂抹任何制剂。通过盒盖的针孔注射入臭味物质,臭味物质采用三组,一组为尿便混合液,一组为女性生理分泌物,另设一组对照组,采用蒸馏水。三组样品均置于室温和40%的湿度环境,放置4-5h后抽取10ml,注射针管注入样品和空白组密闭盒。采用感官评估方法,由10-20名试验人员双盲条件下,打开盒体,5cm距离内进行气味嗅闻评分,每个样品测试3次,取平均值。采用分值计算臭味程度。5:强烈恶臭;4:较强的臭味;3:易于闻到的不舒服的臭味;2:可以容忍的臭味;1:微弱的味道;0:没有任何味道。测量评估在样品注入5min,30min,50min后分别进行。提取物组和酵母菌多肽组在50min后进行测评。
可见,随着时间延长,臭味程度越低,制剂除臭效果越好,可能是组合物对***物中的脲酶产生了抑制作用,或***物中的导致臭味增加的物质减少导致,酵母菌多肽的除臭作用明显,提取物组可能是通过抑制细菌的作用消除了少量臭味。
实施例7皮肤效果试验
选取市售普通纸尿裤,测试对象为有尿布皮疹患病历史的0-2岁婴儿,试验组涂抹本发明实施例2所述乳剂,对照组使用普通尿布疹乳膏,空白组不使用任何制剂。使用前24小时未使用任何抗过敏药物或外用制剂。采用多中心随机对照研究,试验组/对照组/空白组各15例,分别采用实施例2乳剂/医院普通乳膏和不采用任何制剂,每天两次涂布观察,7天进行对比。
组别 | 皮肤明显可见粘附***物 | 可见红色斑 | 红肿出现 | 丘疹 | 溃烂并发感染 |
试验组 | 1 | 0 | 0 | 0 | 0 |
对照组 | 8 | 5 | 2 | 1 | 0 |
空白组 | 15 | 11 | 11 | 6 | 2 |
宝宝测试结果表明:本发明组合物制剂可以改善皮肤黏附***物的情况,让皮肤更为洁净干爽,且尿布疹症状和皮肤受损情况优于医院普通尿布疹乳膏。
根据上述试验结果,可以看出本发明组合物之间具有协同增效的效果,对皮肤保护隔离作用较好,涂布后不仅改善***物黏附性,消除***物臭味,还具有天然抗菌抑菌,护肤舒敏的功效。皮肤干燥舒爽感提高,酵母菌多肽不仅改善了***物味道,而且增强植物提取物抗菌作用,植物提取物的联合使用则抑制了细菌的滋生,没有刺激性和皮肤敏感性。其制备的纸尿裤表层整体使用后,尿布疹及其并发症显著降低,臭味消失,皮肤更容易保持健康清洁状态。
以上为对本发明实施例的描述,通过对所公开的实施例的上述说明,使本领域专业技术人员能够实现或使用本发明。对这些实施例的多种修改对本领域的专业技术人员来说将是显而易见的。本文中所定义的一般原理可以在不脱离本发明的精神或范围的情况下,在其它实施例中实现。因此,本发明将不会被限制于本文所示的这些实施列,而是要符合与本文所公开的原理和新颖点相一致的最宽的范围。
Claims (5)
1.一种护肤抗菌纸尿裤,其特征在于,该纸尿裤透液表层为无纺布材料或天然纤维材料,并含有皮肤卫生护理组合物;皮肤卫生护理组合物包括按重量计的如下组分:酵母菌多肽冻干粉2-4份,葡萄柚提取物1-3份,蓝莓提取物1-6份,五香血藤提取物0.5-8份,白芨粉末1-2份,透明质酸钠 2.5-4份,乳酸薄荷酯0.1-1.5份,氢化聚异丁烯0.1-1.5份。
2.根据权利要求1所述的一种护肤抗菌纸尿裤,其特征在于,葡萄柚提取物提取工艺为,将清洗干净的葡萄柚皮和种子干燥粉碎成粗粉后,加入5-50倍量的70-95℃热水中,超声提取1-2h,重复3次,提取液合并过滤并浓缩、冷冻干燥得到葡萄柚提取物A组份;将上述过滤沉渣加入质量分数为35-85%的乙醇水溶液中,搅拌静置0.5-1h,过滤后提取滤液,重复三次,合并收集滤液,加热浓缩,烘干,得到葡萄柚提取物B组份,将上述A、B组份混合得到葡萄柚提取物粉末。
3.根据权利要求1所述的一种护肤抗菌纸尿裤,其特征在于,蓝莓提取物提取工艺为:取蓝莓果实,充分破碎后用体积分数0.5%HCl和65-85%乙醇水溶液按照质量体积比1:15混合均匀,30°C下超声波辅助提取30min,提取液过滤后合并收集滤液,浓缩,干燥,得蓝莓提取物粉末。
4.根据权利要求1所述的一种护肤抗菌纸尿裤,其特征在于,五香血藤提取物通过如下方法制备,洗净五香血藤,干燥后置于粉碎机中进行粉碎处理,碾磨机中充分研磨,加入索氏提取器中,加入乙醇溶液,加热回流0.5-2h,收集乙醇,得到五香血藤提取液体,对其进行喷雾干燥或冷冻干燥,得到五香血藤提取物粉末。
5.根据权利要求1所述护肤抗菌纸尿裤的制备方法,其特征在于,使用无纺布材料或天然纤维材料,并通过如下方法制成,葡萄柚提取物1-3份,蓝莓提取物1-6份,五香血藤提取物0.5-8份,各自洗净干燥粉碎碾磨后,混合加入5-50倍量乙醇,搅拌加入白芨粉末0.5-1份,上述混合物在40-80℃条件下超声0.5-1h,静置后回收乙醇得到植物提取物,加入透明质酸钠 2.5-4份,乳酸薄荷酯0.1-1.5份,氢化聚异丁烯0.1-1.5份,加入去离子水搅拌混合均匀,得到药物溶液,使用浸渍法,将无纺布材料或天然纤维材料浸入上述溶液中,轧液率为30-40%,温度25-45℃,处理0.5-1h后紫外线消毒,酵母菌多肽冻干粉1-3份溶于去离子水中,浓度0.5g/100ml,均匀喷洒后,低温干燥定型,得到纸尿裤透液表层。
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