CN111903661A - Liquid nitrogen storage device - Google Patents
Liquid nitrogen storage device Download PDFInfo
- Publication number
- CN111903661A CN111903661A CN201910380548.6A CN201910380548A CN111903661A CN 111903661 A CN111903661 A CN 111903661A CN 201910380548 A CN201910380548 A CN 201910380548A CN 111903661 A CN111903661 A CN 111903661A
- Authority
- CN
- China
- Prior art keywords
- liquid nitrogen
- articles
- lifting
- low
- freezing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 title claims abstract description 304
- 239000007788 liquid Substances 0.000 title claims abstract description 152
- 229910052757 nitrogen Inorganic materials 0.000 title claims abstract description 152
- 230000007246 mechanism Effects 0.000 claims abstract description 36
- 238000005057 refrigeration Methods 0.000 claims abstract description 14
- 238000007710 freezing Methods 0.000 claims description 80
- 230000008014 freezing Effects 0.000 claims description 80
- 238000009434 installation Methods 0.000 claims description 8
- 230000000149 penetrating effect Effects 0.000 claims description 3
- 230000002441 reversible effect Effects 0.000 claims description 3
- 238000000034 method Methods 0.000 abstract description 43
- 230000008569 process Effects 0.000 abstract description 34
- 230000000694 effects Effects 0.000 abstract description 5
- 239000000523 sample Substances 0.000 description 21
- 238000005138 cryopreservation Methods 0.000 description 13
- 238000012360 testing method Methods 0.000 description 11
- 238000012546 transfer Methods 0.000 description 10
- 238000012545 processing Methods 0.000 description 7
- 238000010586 diagram Methods 0.000 description 5
- 238000000605 extraction Methods 0.000 description 4
- 230000032258 transport Effects 0.000 description 3
- 230000007306 turnover Effects 0.000 description 3
- 239000012472 biological sample Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 238000000151 deposition Methods 0.000 description 2
- 210000000130 stem cell Anatomy 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000003578 releasing effect Effects 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0236—Mechanical aspects
- A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
Landscapes
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- Mechanical Engineering (AREA)
- Health & Medical Sciences (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
Abstract
The invention discloses a liquid nitrogen storage device, comprising: the liquid nitrogen container is provided with an access port, and liquid nitrogen is contained in the liquid nitrogen container; an automatic storing and taking mechanism configured with a selecting operation space for forming a first low-temperature storage area after refrigeration; the automatic storing and taking mechanism is also provided with a movable clamp which is used for clamping and transporting the articles taken out of the liquid nitrogen tank or the articles to be stored in the liquid nitrogen tank, and the clamp is also used for picking the articles in the first low-temperature storage area. Articles are stored at low temperature in the process of being selected outside the liquid nitrogen tank, so that the influence of the ambient temperature at room temperature is reduced, the tube selecting operation is completed under the low-temperature environment to ensure the activity of the sample, and the use reliability is improved.
Description
Technical Field
The invention belongs to the technical field of liquid nitrogen storage, and particularly relates to liquid nitrogen storage equipment.
Background
At present, the liquid nitrogen container is in the medical instrument field mainly used cryopreservation biological samples such as blood, stem cell, and the liquid nitrogen container is including jar body and the freezing frame of setting in jar body usually, and then place a plurality of freezing boxes that are used for holding the sample on the freezing frame. In the in-service use process, when the sample is deposited or is taken out, the cryopreservation box needs to be taken out from the cryopreservation frame, and then the box cover of the cryopreservation box is opened to carry out tube picking operation. During the tube-picking operation, the temperature of the sample is increased due to the exposure of the sample to the room temperature environment, thereby affecting the activity of the sample. How to design a technology for completing tube picking operation in a low-temperature environment to ensure the activity of a sample is a technical problem to be solved by the invention.
Disclosure of Invention
Aiming at the technical problems in the prior art, the invention provides the liquid nitrogen storage equipment, articles are stored at low temperature in the process of being selected outside the liquid nitrogen tank so as to reduce the influence of the ambient temperature at room temperature, the tube selection operation is completed in the low-temperature environment so as to ensure the activity of the sample, and the use reliability is improved.
In order to realize the purpose of the invention, the invention is realized by adopting the following technical scheme:
the invention provides a liquid nitrogen storage device, comprising:
the liquid nitrogen container is provided with an access port, and liquid nitrogen is contained in the liquid nitrogen container;
an automatic storing and taking mechanism configured with a selecting operation space for forming a first low-temperature storage area after refrigeration; the automatic storing and taking mechanism is also provided with a movable clamp which is used for clamping and transporting the articles taken out of the liquid nitrogen tank or the articles to be stored in the liquid nitrogen tank, and the clamp is also used for picking the articles in the first low-temperature storage area.
Further, the automatic access mechanism comprises:
and the mounting platform is provided with an operation port, the mounting platform is mounted on the liquid nitrogen tank, the access port is positioned in the operation port, and the selection operation space is arranged on the mounting platform.
Furthermore, a selection barrel is arranged on the mounting platform and forms the selection operation space; and a first liquid nitrogen supply pipe is arranged on the selecting barrel and used for conveying liquid nitrogen into the selecting barrel to form the first low-temperature storage area.
Furthermore, the selection operation space is a groove structure formed on the mounting platform, a second liquid nitrogen supply pipe is arranged in the groove structure, and the second liquid nitrogen supply pipe is used for conveying liquid nitrogen into the groove structure to form the first low-temperature storage area.
Further, a freezing frame for storing articles to be stored is arranged in the liquid nitrogen tank;
the automatic access mechanism further comprises:
the lifting assembly is provided with a lifting connecting part which can move up and down, and the lifting connecting part is used for penetrating through the access port to be connected with the freezing frame and lifting the freezing frame out of the liquid nitrogen tank;
wherein the lifting assembly is mounted on the mounting platform.
Further, the lifting assembly comprises:
the lifting module is used for driving the lifting connecting part to move up and down;
the lifting channel is used for forming a second low-temperature storage area after refrigeration;
wherein, the lifting connection part is also used for pulling out the freezing storage rack and sending the freezing storage rack into the second low-temperature storage area.
Further, the lifting assembly further comprises:
the pushing module is provided with a pushing part capable of moving back and forth, the pushing part is used for pushing the articles on the freezing frame out of the lifting channel, and the pushing part is also used for pushing the external articles into the freezing frame for storage;
wherein the push module is located at a lower portion of the lifting channel.
Further, a third liquid nitrogen supply pipe is arranged on the lifting channel and used for spraying liquid nitrogen into the lifting channel to form the second low-temperature storage area.
Furthermore, a tank cover capable of being opened and closed is arranged on the access opening;
the automatic access mechanism further comprises:
a switch cover assembly provided with a reversible connecting arm connecting the can lid;
the sliding component is provided with a sliding part capable of sliding transversely, and the sliding part is used for driving the lifting component to slide transversely and reciprocally;
the switch cover assembly is installed on the mounting platform and located on one side of the operation opening, a vertical support is arranged on the mounting platform, and the sliding assembly is installed on the vertical support.
Further, the automatic access mechanism further comprises:
and the moving module is used for driving the clamp to move, and the moving module is installed on the installation platform.
Compared with the prior art, the invention has the advantages and positive effects that: through the outside at the liquid nitrogen container first low temperature storage area that forms for when article externally select the processing, first low temperature storage area can be treated the article of selecting the processing and carry out low temperature protection, avoids article to receive the influence of room temperature ambient temperature in the selection process and heaies up too high and cause the damage, realizes selecting in-process whole low temperature access in order to improve the use reliability. Especially for samples stored by liquid nitrogen, the method is more beneficial to ensure that the samples keep good activity.
Other features and advantages of the present invention will become more apparent from the following detailed description of the invention when taken in conjunction with the accompanying drawings.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings needed to be used in the embodiments are briefly introduced below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts.
FIG. 1 is a schematic diagram of the structure of an embodiment of a liquid nitrogen storage device of the present invention;
FIG. 2 is a schematic diagram of an automatic accessing mechanism in an embodiment of a liquid nitrogen storage device according to the present invention;
FIG. 3 is a schematic diagram of a clamp according to an embodiment of the liquid nitrogen storage device of the present invention;
FIG. 4 is a schematic diagram of a lifting assembly in an embodiment of a liquid nitrogen storage device of the present invention;
FIG. 5 is a schematic diagram of a pushing module in an embodiment of a liquid nitrogen storage device according to the present invention;
FIG. 6 is a cross-sectional view of a liquid nitrogen tank in an embodiment of a liquid nitrogen storage device of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention will be described in further detail with reference to the accompanying drawings and examples.
It should be noted that in the description of the present invention, the terms of direction or positional relationship indicated by the terms "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. are based on the directions or positional relationships shown in the drawings, which are merely for convenience of description, and do not indicate or imply that the device or element must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first" and "second" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
As shown in fig. 1 to 6, the liquid nitrogen storage device of the present embodiment includes:
a liquid nitrogen tank 1 provided with an access port 11, the liquid nitrogen tank 1 containing liquid nitrogen therein;
an automatic storage/retrieval mechanism 2 provided with a selection operation space for forming a first low-temperature storage region after cooling; the automated storage and retrieval mechanism 2 is further provided with a movable gripper 21, the gripper 21 being used for gripping and transporting an article taken out of the liquid nitrogen tank 1 or an article to be stored in the liquid nitrogen tank 1, the gripper 21 being also used for picking up an article in the first low-temperature storage area.
Specifically, liquid nitrogen is added to the liquid nitrogen tank 1 to form a low-temperature refrigeration environment, and articles such as biological samples (e.g., blood, stem cells) that need to be stored at low temperature are stored in the liquid nitrogen tank 1 through the access port 11. When an article taken out of the liquid nitrogen tank 1 or an article to be stored in the liquid nitrogen tank 1 is required to be subjected to a sorting operation, the article is transferred by the clamp into the sorting operation space, and the article is subjected to the sorting operation in the first low-temperature storage region. In the selecting process, the first low-temperature storage area can carry out low-temperature protection on the articles so as to reduce the influence of the room-temperature environment on the articles. Examples are as follows: be provided with rotatable storage frame 12 in the liquid nitrogen container 1, be provided with the freezing frame 13 that takes out on the storage frame 12, placed a plurality of freezing boxes (not shown) on freezing frame 13, and placed a plurality of sample test tubes in every freezing box, the article of waiting to take out is one of them freezing a certain sample test tube in the box. The specific selection process is that the freezing frame 13 is pulled out from the access port 11 of the liquid nitrogen tank 1, and the clamp 21 clamps the corresponding freezing box and transfers the freezing box to the selection operation space; then, the cover of the cryopreservation box is opened by the clamp 21, and the clamp 21 is used for selecting the required sample test tube to complete the selection operation.
For the automatic access mechanism 2, for convenience of installation and fixation with the liquid nitrogen tank 1, the automatic access mechanism 2 comprises: the installation platform 20, the installation platform 20 is provided with an operation opening (not marked), the installation platform 20 is installed on the liquid nitrogen tank 1, and the access opening 11 is positioned in the operation opening. Specifically, the mounting platform 20 is located above the liquid nitrogen tank 1 such that the access port 11 is located in the operation port, and the clamp 21 is moved to the operation port position and takes out the article in the liquid nitrogen tank 1 through the access port 11, or deposits the article into the liquid nitrogen tank 1.
There are various forms for selecting the concrete representation entity of the operation space, for example: a groove structure can be directly formed on the mounting platform 20, the groove structure forms a selection operation space, and before selection processing, refrigeration processing is performed on the interior of the groove structure to form a first low-temperature storage area; alternatively, a selection bucket 25 may be additionally provided, the selection bucket 25 is disposed on the mounting platform 20, before the selection process, the interior of the selection bucket 25 is refrigerated to form a first low-temperature storage area, and the articles gripped by the gripper 21 are put into the selection bucket 25 for selection.
In addition, in order to facilitate access to and access to the articles, a rotatable storage rack 12 is provided in the liquid nitrogen tank 1, and a freezing rack 13 is placed on the storage rack 12. Specifically, the storage rack 12 is provided with a rotating shaft 121, the rotating shaft 121 is rotatably installed in the liquid nitrogen tank 1, in order to facilitate automatic driving, one end of the rotating shaft 121 extends out of the liquid nitrogen tank 1, and the end of the rotating shaft 121, which is located outside the liquid nitrogen tank 1, can provide power through a motor 122, so that the rotating shaft 121 drives the storage rack 12 to rotate in the liquid nitrogen tank 1. The storage rack 12 is further provided with a plurality of freezing racks 13 around the rotary shaft 121, and the freezing racks 13 can move up and down. When the freezing rack 13 moves to the lower part of the access opening 11, the freezing rack 13 can be pulled out from the liquid nitrogen tank 1, so that the articles stored in the freezing rack 13 can be taken out, and the articles to be stored from the outside can be put into the freezing rack 13.
Further, when an article needs to be taken out of the liquid nitrogen tank 1 or an external article needs to be stored in the liquid nitrogen tank 1, the article to be taken in and out needs to be transported, and in the process, the article is transported in a room temperature environment. In order to ensure that good cryogenic storage conditions are maintained during the transfer process, refrigerated clamps 21 are used to grip the articles for transfer. Specifically, before the clamp 21 clamps the articles, the clamp 21 performs a refrigeration process to form the third low-temperature storage area 100, and during the process of clamping the articles and transferring the articles, the articles will be located in the third low-temperature storage area 100, so that the articles during the transfer process can still be temporarily stored in the low-temperature environment. Therefore, the articles can be ensured not to be excessively heated under the influence of the room temperature environment in the transferring process. Wherein, to anchor clamps 21, dispose usually and remove module 24, remove the module 24 installation and fix on mounting platform 20, remove module 24 and can drive anchor clamps 21 and remove to satisfy the transportation requirement of article. The mobile module 24 may be embodied in various forms. For example: the moving module 24 can adopt a mechanical arm, the clamp 21 is installed and fixed at the installation position of the mechanical arm, and the clamp 21 is driven to move by the mechanical arm; or, the moving module 24 may adopt a three-dimensional moving platform, and then the clamp 21 is installed in a moving portion of the three-dimensional moving platform, and the three-dimensional moving platform may drive the clamp 21 to move so as to meet the requirement of article transportation.
Further, in order to realize that the third low temperature storage region 100 is formed after the cooling process is performed on the jig 21. The jig 21 includes: a first clamping jaw 211, a first driving mechanism 212 and a fixed seat 213; the first clamping jaw 211 is provided with heat-insulating shells 2111, and a third low-temperature storage area 100 is formed between the two heat-insulating shells 2111; the first driving mechanism 212 is used for driving the two oppositely arranged first clamping jaws 211 to move relatively so as to complete the clamping and releasing actions; the first driving mechanism 212 is mounted on the fixed base 213. Specifically, the first clamping jaw 211 can move relatively under the driving action of the first driving mechanism 212 to clamp or release the article. The fixed seat 210 is fixedly installed on the moving module 24, so that the moving module 24 can drive the clamp 21 to move. There are various forms for the concrete representation of the first driving mechanism 213, for example: electric jaws, or pneumatic fingers, etc. In addition, in order to avoid the first clamping jaw 211 from transmitting cold to the first drive mechanism 213, the first clamping jaw 211 can be mounted to the first drive mechanism 213 via a thermally isolating connection 2112, for example: one end of the thermal isolation connector 2112 is connected to the first jaw 211 by a screw, and the other end is fixed to the first driving mechanism 212 by a screw.
Still further, in order to realize that the freezing rack 13 is automatically extracted, the automatic storing and taking mechanism 2 further includes: the lifting assembly 22 is provided with a lifting connecting part 221 capable of moving up and down, and the lifting connecting part 221 is used for penetrating through the access opening 11 to be connected with the freezing frame 13 and lifting and pulling the freezing frame 13 out of the liquid nitrogen tank 1. Specifically, when the freezing rack 13 in the liquid nitrogen tank 1 needs to be taken out, the lifting connection portion 221 in the lifting assembly 22 moves downward, the lifting connection portion 221 enters the liquid nitrogen tank 1 through the access opening 11, and the lifting connection portion 221 is finally connected with the freezing rack 13. Then, the lifting assembly 22 pulls the lifting connection 221 upward to take out the cryopreserved rack 13 from the liquid nitrogen tank 1. For the concrete entity of the lifting connection portion 221, a hook, an electromagnetic absorption mode, and the like can be adopted, which is not limited herein.
Preferably, in order to ensure that the extracted articles on the cryopreservation rack 13 can obtain a good low-temperature storage environment, the lifting assembly 22 specifically comprises: a lifting module 222 and a lifting channel 223; the lifting module 222 is used for driving the lifting connection part 221 to move up and down, and the lifting channel 223 is used for forming a second low-temperature storage area after refrigeration; the lifting connection 221 is also used to bring the drawn-out freezers 13 into the second low temperature storage area. Specifically, the lifting module 222 can drive the lifting connection portion 221 to move up and down so as to allow the lifting connection portion 221 to enter and exit the liquid nitrogen tank 1 to access the cryopreservation rack 13, and the concrete representation entity of the lifting module 222 has various forms. For example: the lifting module 222 may adopt a mode of a chain wheel matching a chain, that is, the lifting connection portion 221 is connected to one end of the chain, and the lifting connection portion 221 is driven by the chain to move up and down by driving the chain wheel to rotate; or, the lifting module 222 may adopt a manner of a gear matching with a rack, that is, the lifting connection portion 221 is connected to the lower end portion of the rack, and the driving gear rotates to drive the lifting connection portion 221 to move up and down through the rack, where the concrete representation entity of the lifting module 222 is not limited. Before the freezing rack 13 is taken out of the liquid nitrogen tank 1, the lifting passage 223 is refrigerated to form a second low temperature storage region in the lifting passage 223. The lifting connection part 221 directly enters the lifting channel 223 after pulling out the freezing frame 13, so that the freezing frame 13 separated from the liquid nitrogen tank 1 can be stored in the lifting channel 223 at low temperature, and good low-temperature storage environment of articles on the freezing frame 13 is ensured.
In order to facilitate the clamp 21 to clamp the articles to be taken out from the freezing frame 13 or store the articles clamped by the clamp 21 on the freezing frame 13; the lift assembly 22 further includes: the pushing module 224, the pushing module 224 is provided with a pushing part 2241 capable of moving back and forth, the pushing part 2241 is used for pushing the articles on the freezing rack 13 out of the lifting passage 223, and the pushing part 2241 is also used for pushing the articles outside into the freezing rack 13 for storage; wherein the push module 224 is located at a lower portion of the lifting passage 223. Specifically, in the process of taking out the articles from the freezing rack 13 or storing the articles in the freezing rack 13, the pushing part 2241 in the pushing module 224 pushes the articles to move, so as to enter and exit the freezing rack 13. The pushing module 224 is arranged at the lower part of the lifting channel 223, and in the process that the lifting connecting part 221 drives the freezing frame 13 to lift, the pushing part 2241 is positioned at one side to avoid influencing the moving freezing frame 13; after the freezing rack 13 is moved to the right position, the pushing unit 2241 is moved to push out the articles on the freezing rack 13, and similarly, the articles outside can be pushed into the freezing rack 13 to be stored. The article pushed out by the pushing unit 2241 can be gripped by the gripper 21 to be transferred; and for the article to be transferred to the pushing module 224 by the clamp 21, the article can be pushed into the freezing rack 13 by the pushing part 2241 for storage. There are various ways to realize the reciprocating movement of the pushing part 2241, for example: the pushing part 2241 can be driven to reciprocate by adopting an electric push rod mode; alternatively, a gear is matched with a rack, the gear can be driven by the motor 2242, the pushing part 2241 is installed on the rack, and the motor 2242 drives the gear to rotate so as to drive the rack to slide, so that the pushing part 2241 can reciprocate. The entity of the pushing part 2241 may be a push plate or a push block, and the like, which is not limited herein.
In addition, in order to reduce the volatilization amount of liquid nitrogen in the liquid nitrogen tank 1, a tank cover 14 which can be opened and closed is arranged on the access port 11 of the liquid nitrogen tank 1; and the automatic access mechanism 2 further comprises: the switch cover assembly 24, the switch cover assembly 24 is provided with a reversible connecting arm 241, and the connecting arm 241 is connected with the tank cover 14. When the articles need to be accessed, the connecting arm 241 in the switch cover assembly 24 rotates to automatically open the lid 14, and the lifting module 222 can extend into the liquid nitrogen tank 1 through the lifting connecting part 221 to take out the freezing rack 13. After the access operation is completed, the connecting arm 241 is rotated in the opposite direction, so that the lid 14 automatically closes the access opening 11. For the power source of the connecting arm 241, the rotating driving mechanism 242 may be used to drive the connecting arm 241 to rotate, and the representation entity of the rotating driving mechanism 242 may be a rotating motor, etc., without limitation.
In order to avoid the interference between the lifting assembly 22 and the switch cover assembly 23, the automatic access mechanism 2 further includes a sliding assembly 26, the sliding assembly 26 has a sliding portion (not shown) capable of sliding transversely, and the sliding portion is used for driving the lifting assembly 22 to slide transversely and reciprocally; the switch cover assembly 24 is mounted on the mounting platform 20 at one side of the operation opening, the mounting platform 20 is provided with an upright bracket, and the sliding assembly 26 is mounted on the upright bracket. Specifically, the sliding component 26 can drive the lifting component 22 to move transversely through the sliding portion, during the opening and closing of the tank cover 14, the sliding component 26 drives the lifting component 22 to move away from the operation opening, and when the tank cover 14 needs to be opened to access the object, the sliding component 26 drives the lifting component 22 to move above the operation opening. The representation of the sliding assembly 26 may employ a sliding platform or a linear motor to achieve the transverse reciprocating motion, which is not limited herein.
Preferably, in order to facilitate the picking operation by the gripper 21, the gripper 21 further includes: a second clamping jaw 214 and a second driving mechanism 215, the second driving mechanism 215 is used for driving the two second clamping jaws 214 to move relatively, and the second driving mechanism 215 is installed on the fixed seat 213. Specifically, after the gripper 21 puts the article into the picking operation space through the first gripper 211, the gripper 21 switches the second gripper 214 to the working position, and the second driving mechanism 215 drives the second gripper 214 to move to pick up the article in the picking operation space. Examples are as follows: taking the sample tubes stored in the freezing storage box as the articles to be accessed, a plurality of sample tubes are usually stored in the freezing storage box on the freezing storage rack 13 in the liquid nitrogen tank 1. When a certain sample test tube needs to be taken out, the clamp 21 conveys the cryopreservation box to the selection operation space through the first clamping jaw 211, and at the moment, a plurality of sample test tubes in the cryopreservation box are all in the first low-temperature storage area for low-temperature storage. During selection, the clamp 21 switches the second clamping jaw 214 to be at a working station, and the required sample test tube in the cryopreservation box is selected through the second clamping jaw 214. The above process is a process of taking out the sample test tube, and a process of storing the sample test tube in the cryopreservation box is not described herein again.
In order to facilitate switching the work of the first clamping jaw 211 and the second clamping jaw 214, the clamp 21 further comprises: and the rotating module 216 is mounted on the moving module 24, and is used for driving the fixed seat 213 to rotate. Specifically, when the first clamping jaw 211 and the second clamping jaw 214 are switched to work, the rotating module 216 drives the fixing seat 213 to rotate so as to drive the first clamping jaw 211 and the second clamping jaw 214 to rotate, so that the first clamping jaw 211 or the second clamping jaw 214 is arranged towards the working posture. The rotating module 216 may be a rotating motor or a rotating cylinder. Where a multi-axis robot is used for the motion module 24, the rotation module 216 may be integrated into the moving end of the multi-axis robot.
For the low-temperature storage region formed by the refrigeration method, the refrigeration method can adopt various forms. For example: the compressor may be used to produce cold air, which is used to form a corresponding cold storage region. Preferably, the low-temperature storage regions may be formed by adding liquid nitrogen for convenience of practical operation and reduction of use cost, and the formation of each low-temperature storage region will be described below. With respect to the third cryogenic storage area 100 formed by clamp 21, the inside of thermal shell 2111 is filled with liquid nitrogen, which forms a third cryogenic storage area between the two thermal shells 2111. As for the second cryogenic storage region formed by the lifting passage 223, liquid nitrogen is injected into the lifting passage 223 in the same manner, and the second cryogenic storage region can be formed in the lifting passage 223 by using the liquid nitrogen. For the first low-temperature storage region, for example, in the case of the sorting bucket 25, liquid nitrogen is added to the sorting bucket 25, so that the first low-temperature storage region can be formed in the sorting bucket 25. The liquid nitrogen can be injected into the cryogenic storage area by a delivery pipe. For the clamp 21, a liquid nitrogen supply pipe is provided on the heat-insulating housing 2111, the liquid nitrogen supply pipe can be connected to a liquid nitrogen supply tank, and liquid nitrogen in the liquid nitrogen supply tank flows into the liquid nitrogen supply pipe to form a third low-temperature storage region between the two heat-insulating housings 2111. As for the lifting passage 223, a liquid nitrogen supply pipe is also provided on the lifting passage 223, and sprays liquid nitrogen from the top of the lifting passage 223 to form a second cryogenic storage region. As for the sorting bucket 24, a liquid nitrogen supply pipe is also provided on the sorting bucket 24, and the liquid nitrogen supply pipe inputs liquid nitrogen to the bottom of the sorting bucket 24 to form a first low-temperature storage region.
Based on the liquid nitrogen storage device, the low-temperature transportation is realized by adopting the following method, and the low-temperature transportation method comprises the following steps: after the clamp is refrigerated to form a third low-temperature storage area in the clamp, the clamp is used for clamping the articles to be stored and taken for transferring, and the articles are located in the third low-temperature storage area in the transferring process. Specifically, before the articles to be stored and taken are transported, the clamp is refrigerated, and after the clamp is refrigerated, a third low-temperature storage area is formed in the clamp. In the process of transferring the articles to be stored and taken, the articles are located in the third low-temperature storage area, so that the articles are protected by a low-temperature environment in the transferring process, and excessive temperature rise caused by the influence of the room-temperature environment is avoided.
In the actual use process, the low-temperature transferring method correspondingly comprises an extracting process and a storing process for taking out and storing the articles, which are specifically described as follows.
For the extraction process, the articles stored in the liquid nitrogen tank are taken out and transported to other storage components, such as: the following description will be made by taking the articles in the liquid nitrogen tank out and transferring them to the transfer tank. The extraction process comprises the following steps: after refrigerating the anchor clamps and handling in order to form third low temperature storage environment, utilize anchor clamps to press from both sides the article of taking out from the liquid nitrogen container and carry out the transportation and handle, finally, anchor clamps put into the turnover bucket with article and accomplish the transportation operation. After the article is taken out from the liquid nitrogen tank, in the transfer process, the article is protected at a third low-temperature storage environment formed by the clamp, and the adverse influence of the room-temperature environment on the high temperature of the article in the transfer process is reduced. The liquid nitrogen tank can be provided with a plurality of removable storage units, and the storage units are provided with a plurality of stations for storing articles. The freezing frame is used in the liquid nitrogen tank as an example for explanation, and a plurality of articles can be stored on the freezing frame at the same time. In the extraction step, a plurality of articles are taken out at a time from the liquid nitrogen tank. For this purpose, the extraction process further comprises: before the articles in the liquid nitrogen tank are taken out, the articles are firstly subjected to refrigeration treatment outside the access opening of the liquid nitrogen tank to form a second low-temperature storage area, specifically, the contents of the embodiment of the liquid nitrogen storage device are referred, a lifting channel is configured above the access opening of the liquid nitrogen tank, and the freezing frame enters the lifting channel for temporary storage after being taken out. Before the freezing frame is taken out, the interior of the lifting channel is subjected to refrigeration treatment to form a second low-temperature storage area, so that the freezing frame is taken out and then enters the second low-temperature storage area to be stored at low temperature, and low-temperature protection is effectively carried out on a plurality of articles stored on the freezing frame, so that the articles taken out of the liquid nitrogen tank are temporarily stored in the second low-temperature storage area. And then, the clamp is used for clamping the articles output from the second low-temperature storage area and carrying out transfer processing. In the embodiment of the liquid nitrogen storage device, the pushing module is adopted to push the articles stored on the freezing storage rack out of the lifting channel, so that the clamp can clamp the pushed articles.
And aiming at the storage process, storing the articles to be stored outside into a liquid nitrogen tank. For example: the following description will be given taking an example in which the articles transported in the turnover tank are stored in a liquid nitrogen tank. The storage process comprises the following steps: after refrigerating the clamp to form a third low-temperature storage environment, clamping the articles to be stored by using the clamp and transporting the articles to the access opening of the liquid nitrogen tank, and storing the articles in the liquid nitrogen tank. Specifically, the clamp clamps and takes out the articles from the turnover barrel, and finally transports the articles to the liquid nitrogen tank, and the articles are stored in the liquid nitrogen tank. Wherein, the article can be directly put into the liquid nitrogen container through the clamp to finish the transferring operation. And adopt to freeze to deposit under the condition of similar structure storing such as frame to the liquid nitrogen container, then anchor clamps can't directly deposit article in the liquid nitrogen container, and the process of specifically depositing is as follows: before the articles are stored in the liquid nitrogen tank, the articles are firstly refrigerated outside an access opening of the liquid nitrogen tank to form a second low-temperature storage area, the articles are transferred to the second low-temperature storage area by the clamp for temporary storage, and then the articles in the second low-temperature storage area are placed into the liquid nitrogen tank. Specifically, referring to the content of the embodiment of the liquid nitrogen storage device, before the freezing rack is taken out, the inside of the lifting channel is refrigerated to form a second low-temperature storage area, and then the freezing rack is lifted into the second low-temperature storage area. The clamp transports the articles to the lifting channel, pushes the articles to the freezing frame through the pushing module for storage, and finally, the freezing frame is stored back to the liquid nitrogen tank. The freezing frame lifted from the access port of the liquid nitrogen tank is temporarily stored in the second low-temperature storage area, so that good low-temperature protection of articles stored on the freezing frame in the second low-temperature storage area can be ensured in the storage process.
In addition, if there is an operation of sorting the stored articles outside the liquid nitrogen tank, the cryogenic transfer method further includes a sorting step. The selecting process specifically comprises the following steps of before the articles are stored in the liquid nitrogen tank or after the articles are taken out of the liquid nitrogen tank: the method comprises the steps that refrigeration processing is carried out outside a liquid nitrogen tank to form a first low-temperature storage area, a plurality of articles are clamped by a clamp and transported into the first low-temperature storage area, and after the required articles are selected in the first low-temperature storage area, the clamp is used for clamping the selected articles to continue transportation processing. Specifically, in the process of selecting the articles, the articles are selected in the first low-temperature storage area, and the first low-temperature storage area can perform low-temperature protection on the articles to be selected so as to avoid the condition that the articles are influenced by the room-temperature environment and are heated too high in the selecting process. The freezing storage rack is used for placing the freezing storage box, a plurality of sample test tubes are placed in the freezing storage box, and the taken-out articles are taken as certain sample test tubes in the freezing storage box for illustration. The frame is deposited to freezing is pulled out and is had in the lifting passage, deposits the box with freezing that corresponds through promoting the module and pushes away from and remove to the outside that promotes the passageway from depositing the frame to freezing, and anchor clamps are then got and are deposited the box and transport and put into the first low temperature storage area that selects the bucket formation. Then, the box cover of the cryopreservation box is opened through the clamp, and the selection operation of the corresponding sample test tube in the cryopreservation box is carried out. Finally, the required sample tubes are sorted out and stored in a transfer bucket. And for the freezing storage box stored in the selection barrel, the freezing storage box is transported back to the original position through the clamp.
The above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that various changes may be made and equivalents may be substituted for elements thereof; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions.
Claims (10)
1. A liquid nitrogen storage device, comprising:
the liquid nitrogen container is provided with an access port, and liquid nitrogen is contained in the liquid nitrogen container;
an automatic storing and taking mechanism configured with a selecting operation space for forming a first low-temperature storage area after refrigeration; the automatic storing and taking mechanism is also provided with a movable clamp which is used for clamping and transporting the articles taken out of the liquid nitrogen tank or the articles to be stored in the liquid nitrogen tank, and the clamp is also used for picking the articles in the first low-temperature storage area.
2. The liquid nitrogen storage device of claim 1, wherein the automated access mechanism comprises:
and the mounting platform is provided with an operation port, the mounting platform is mounted on the liquid nitrogen tank, the access port is positioned in the operation port, and the selection operation space is arranged on the mounting platform.
3. The liquid nitrogen storage device according to claim 2, wherein a selection barrel is provided on the mounting platform, the selection barrel forming the selection operation space; and a first liquid nitrogen supply pipe is arranged on the selecting barrel and used for conveying liquid nitrogen into the selecting barrel to form the first low-temperature storage area.
4. The liquid nitrogen storage device according to claim 2, wherein the selection operating space is a recessed structure formed on the mounting platform, and a second liquid nitrogen supply pipe is disposed in the recessed structure and is used for delivering liquid nitrogen into the recessed structure to form the first cryogenic storage region.
5. The liquid nitrogen storage device according to claim 2, wherein a freezing rack for storing articles to be stored is provided in the liquid nitrogen tank;
the automatic access mechanism further comprises:
the lifting assembly is provided with a lifting connecting part which can move up and down, and the lifting connecting part is used for penetrating through the access port to be connected with the freezing frame and lifting the freezing frame out of the liquid nitrogen tank;
wherein the lifting assembly is mounted on the mounting platform.
6. The liquid nitrogen storage device of claim 5, wherein the lift assembly comprises:
the lifting module is used for driving the lifting connecting part to move up and down;
the lifting channel is used for forming a second low-temperature storage area after refrigeration;
wherein, the lifting connection part is also used for pulling out the freezing storage rack and sending the freezing storage rack into the second low-temperature storage area.
7. The liquid nitrogen storage device of claim 6, wherein the lift assembly further comprises:
the pushing module is provided with a pushing part capable of moving back and forth, the pushing part is used for pushing the articles on the freezing frame out of the lifting channel, and the pushing part is also used for pushing the external articles into the freezing frame for storage;
wherein the push module is located at a lower portion of the lifting channel.
8. The liquid nitrogen storage device according to claim 6, wherein a third liquid nitrogen supply pipe is provided on the lift channel for injecting liquid nitrogen into the lift channel to form the second cryogenic storage region.
9. The liquid nitrogen storage device as claimed in claim 5, wherein an openable and closable tank cover is provided on the access port;
the automatic access mechanism further comprises:
a switch cover assembly provided with a reversible connecting arm connecting the can lid;
the sliding component is provided with a sliding part capable of sliding transversely, and the sliding part is used for driving the lifting component to slide transversely and reciprocally;
the switch cover assembly is installed on the mounting platform and located on one side of the operation opening, a vertical support is arranged on the mounting platform, and the sliding assembly is installed on the vertical support.
10. The liquid nitrogen storage device of claim 2, wherein the automated access mechanism further comprises:
and the moving module is used for driving the clamp to move, and the moving module is installed on the installation platform.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910380548.6A CN111903661B (en) | 2019-05-08 | 2019-05-08 | Liquid nitrogen storage device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910380548.6A CN111903661B (en) | 2019-05-08 | 2019-05-08 | Liquid nitrogen storage device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN111903661A true CN111903661A (en) | 2020-11-10 |
| CN111903661B CN111903661B (en) | 2024-02-20 |
Family
ID=73242543
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910380548.6A Active CN111903661B (en) | 2019-05-08 | 2019-05-08 | Liquid nitrogen storage device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111903661B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111907941A (en) * | 2019-05-08 | 2020-11-10 | 青岛海特生物医疗有限公司 | Liquid nitrogen storage system |
| CN111907943A (en) * | 2019-05-08 | 2020-11-10 | 青岛海特生物医疗有限公司 | Liquid nitrogen storage device with automatic access function |
| CN111907942A (en) * | 2019-05-08 | 2020-11-10 | 青岛海特生物医疗有限公司 | Liquid nitrogen storage device and using method thereof |
| CN115367319A (en) * | 2022-09-01 | 2022-11-22 | 上海原能细胞生物低温设备有限公司 | Sample warehouse equipment for whole-course cold chain aluminum plate access |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100028214A1 (en) * | 2008-07-31 | 2010-02-04 | Hamilton Storage Technologies, Inc. | Tube picking mechanism for an automated, ultra-low temperature storage and retrieval system |
| CN105857941A (en) * | 2016-04-28 | 2016-08-17 | 上海原能健康管理有限公司 | Cryogenic vial storing and fetching device |
| CN107624751A (en) * | 2017-09-15 | 2018-01-26 | 上海原能细胞生物低温设备有限公司 | Cryogenic storage system |
| CN107688098A (en) * | 2017-09-21 | 2018-02-13 | 基点维科(成都)医疗机器人技术有限公司 | Biological specimen automatic access equipment |
| CN107697530A (en) * | 2017-09-21 | 2018-02-16 | 基点维科(成都)医疗机器人技术有限公司 | Cdna sample transmits storehouse |
| CN207658395U (en) * | 2017-12-05 | 2018-07-27 | 基点维科(成都)医疗机器人技术有限公司 | Biological sample transfer device |
| CN208597615U (en) * | 2018-07-23 | 2019-03-15 | 上海东富龙医疗装备有限公司 | Work chamber is automatically stored in biological sample |
| CN208647604U (en) * | 2018-05-29 | 2019-03-26 | 上海原能细胞生物低温设备有限公司 | A kind of biological sample storage device |
-
2019
- 2019-05-08 CN CN201910380548.6A patent/CN111903661B/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100028214A1 (en) * | 2008-07-31 | 2010-02-04 | Hamilton Storage Technologies, Inc. | Tube picking mechanism for an automated, ultra-low temperature storage and retrieval system |
| CN105857941A (en) * | 2016-04-28 | 2016-08-17 | 上海原能健康管理有限公司 | Cryogenic vial storing and fetching device |
| CN107624751A (en) * | 2017-09-15 | 2018-01-26 | 上海原能细胞生物低温设备有限公司 | Cryogenic storage system |
| CN107688098A (en) * | 2017-09-21 | 2018-02-13 | 基点维科(成都)医疗机器人技术有限公司 | Biological specimen automatic access equipment |
| CN107697530A (en) * | 2017-09-21 | 2018-02-16 | 基点维科(成都)医疗机器人技术有限公司 | Cdna sample transmits storehouse |
| CN207658395U (en) * | 2017-12-05 | 2018-07-27 | 基点维科(成都)医疗机器人技术有限公司 | Biological sample transfer device |
| CN208647604U (en) * | 2018-05-29 | 2019-03-26 | 上海原能细胞生物低温设备有限公司 | A kind of biological sample storage device |
| CN208597615U (en) * | 2018-07-23 | 2019-03-15 | 上海东富龙医疗装备有限公司 | Work chamber is automatically stored in biological sample |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111907941A (en) * | 2019-05-08 | 2020-11-10 | 青岛海特生物医疗有限公司 | Liquid nitrogen storage system |
| CN111907943A (en) * | 2019-05-08 | 2020-11-10 | 青岛海特生物医疗有限公司 | Liquid nitrogen storage device with automatic access function |
| CN111907942A (en) * | 2019-05-08 | 2020-11-10 | 青岛海特生物医疗有限公司 | Liquid nitrogen storage device and using method thereof |
| CN115367319A (en) * | 2022-09-01 | 2022-11-22 | 上海原能细胞生物低温设备有限公司 | Sample warehouse equipment for whole-course cold chain aluminum plate access |
Also Published As
| Publication number | Publication date |
|---|---|
| CN111903661B (en) | 2024-02-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN210213516U (en) | Liquid nitrogen storage device | |
| CN210203096U (en) | Liquid nitrogen storage device | |
| CN210213517U (en) | Liquid nitrogen storage device with automatic access function | |
| CN210213518U (en) | Liquid nitrogen storage system | |
| CN111903661A (en) | Liquid nitrogen storage device | |
| CN111907943A (en) | Liquid nitrogen storage device with automatic access function | |
| CN111908119A (en) | Low temperature transport method | |
| CN111907942A (en) | Liquid nitrogen storage device and using method thereof | |
| CN111907941A (en) | Liquid nitrogen storage system | |
| CN111207545B (en) | Low-temperature access device and low-temperature access method | |
| US8176747B2 (en) | Tube picking mechanism for an automated, ultra-low temperature storage and retrieval system | |
| CN217837545U (en) | Low-temperature intelligent access mechanism for biological samples | |
| CN211353694U (en) | Program cooling and storage device | |
| CN113115764A (en) | Program cooling and storage device | |
| CN111959953A (en) | Basket type sample low-temperature storage device | |
| CN218967858U (en) | Low-temperature transfer operation mechanism for biological samples | |
| CN116588566A (en) | Truss machine liquid nitrogen tank group biological sample large warehouse | |
| CN215884977U (en) | Sample access device | |
| CN212268346U (en) | Basket type sample low-temperature storage device | |
| CN215884720U (en) | Liquid nitrogen storehouse interfacing apparatus and liquid nitrogen storehouse system | |
| CN211153538U (en) | Reproductive sample storage device | |
| CN220689448U (en) | Biological sample access device | |
| CN219905614U (en) | Intelligent biological sample low-temperature storage system | |
| CN111776730B (en) | Biological sample transfer method and transfer device for implementing same | |
| CN220966190U (en) | Freezing equipment for cell freezing bag |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |