CN111888941A - Heparin sodium membrane integration process - Google Patents
Heparin sodium membrane integration process Download PDFInfo
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- CN111888941A CN111888941A CN202010663833.1A CN202010663833A CN111888941A CN 111888941 A CN111888941 A CN 111888941A CN 202010663833 A CN202010663833 A CN 202010663833A CN 111888941 A CN111888941 A CN 111888941A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/58—Multistep processes
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/10—Process efficiency
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Abstract
The invention discloses a heparin sodium membrane integration process, wherein ceramic membrane equipment comprises a first circulation tank, a first feeding pump and a first security filter, wherein a water inlet pipe of the first feeding pump is connected with the first circulation tank, and an outlet end of the first feeding pump is connected with an inlet flange of the first circulation pump after passing through the first security filter. The invention adopts the full membrane process of ceramic membrane and organic membrane, not only separates and concentrates the heparin sodium in the main production process, but also carries out further membrane treatment and recovery on the traditional heparin sodium wastewater, thereby achieving the effects of saving energy consumption and improving the production efficiency of the heparin sodium. The energy consumption of drying can be reduced to 1/5-7 after membrane treatment.
Description
Technical Field
The invention relates to separation and purification and wastewater treatment in a heparin sodium preparation process by applying a membrane separation technology, in particular to a heparin sodium membrane integration process.
Background
The heparin sodium is a mucopolysaccharide contained in mammal body, it is combined with protein and existed in the organs of intestinal mucosa, lung and liver, etc., after the heparin sodium and protein are separated and extracted, it possesses several physiological activities of resisting blood coagulation, resisting thrombosis and reducing blood fat, etc., and is a significant medicine for preventing atherosclerosis and angiocardiopathy and cerebrovascular disease.
At present, the production method of the domestic heparin sodium mainly comprises a salting-out extraction method, an enzymolysis extraction method and other methods, and the specific processes are as follows: salt hydrolysis, resin adsorption, elution, impurity removal, alcohol extraction, dehydration and drying; however, since heparin is a glycosaminoglycan with a particularly complex structure, the molecule of the glycosaminoglycan has polydispersity and heterogeneity, and how to clarify the structure of the glycosaminoglycan is always a timely problem for difficult researchers; the traditional methods such as ion exchange, gel layer filtration and the like are widely applied in the separation and purification of heparin, but the traditional production methods generally require complex refining process, have long production period, are difficult to improve the product purity, generate large amount of waste water and cause serious environmental pollution. Therefore, the present invention provides a heparin sodium membrane integration process to solve the above-mentioned problems.
Disclosure of Invention
The invention aims to provide a heparin sodium membrane integration process to solve the problems in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme:
a heparin sodium membrane integration process comprises filtering with ceramic membrane equipment, filtering with organic membrane equipment, separating, and concentrating;
ceramic membrane filtration: primarily treating the heparin sodium after salt decomposition and enzymolysis to remove macromolecular impurities such as protein through a ceramic membrane to obtain penetrating fluid which is a product containing heparin sodium and micromolecular salts;
and (3) filtering and concentrating by using an organic membrane: the penetrating fluid obtained by filtering the ceramic membrane contains heparin sodium, salt and water micromolecule substances, monovalent salt and water are removed by selecting an organic nanofiltration membrane, the content of the heparin sodium is purified, the heparin sodium can be concentrated to 5-7 times, the penetrating fluid obtained by nanofiltration of the organic membrane contains salt and water which can be used as water for a preorder salt decomposition process, and the concentrated solution enters the next drying process.
As a further scheme of the invention: the ceramic membrane equipment adopts a ceramic ultrafiltration membrane, and the interception aperture is 50 nm.
As a still further scheme of the invention: the protein in the concentrated solution obtained by filtering the ceramic membrane can be used as fertilizer or feed.
As a still further scheme of the invention: the cut-off aperture of the organic nanofiltration membrane is 150-300 DAL.
As a still further scheme of the invention: a heparin sodium membrane integration process, ceramic membrane equipment include circulation tank one, feed pump one and cartridge filter one, the inlet tube of feed pump one links to each other with circulation tank one, and the exit end links to each other with a circulating pump entry flange behind cartridge filter one, membrane module import department sets up a fast-assembling clamp and connects a circulating pump exit end, and a membrane module concentrate pipe partly flows back to circulation tank one in partly flows back to a circulating pump entrance, and a membrane module infiltration side links to each other with the infiltration pipe through the clamp, discharges or retrieves the penetrant.
As a still further scheme of the invention: a heparin sodium membrane integration process, organic membrane equipment include circulation tank two, feed pump two and cartridge filter two, the inlet tube of feed pump two links to each other with circulation tank two, and the exit end links to each other with two entry flanges of circulating pump behind cartridge filter two, two import departments of membrane module set up two exit ends of fast-assembling clamp connection circulating pump, and two concentrated water pipe of membrane module partly flow back to circulation tank two in partly flow back to two entrances of circulating pump, two infiltration sides of membrane module link to each other with the infiltration pipe through the clamp, discharge or retrieve the penetrant.
As a still further scheme of the invention: and the pipelines at the two ends of the first membrane component and the two ends of the second membrane component are respectively provided with a first pressure gauge and a second pressure gauge.
As a still further scheme of the invention: and a first thermometer is arranged on the pipeline at the lower end of the first membrane component.
As a still further scheme of the invention: and a second high-pressure pump is arranged on the pipeline of the second cartridge filter.
As a still further scheme of the invention: and a second regulating valve is arranged on a pipeline at one end of the second high-pressure pump.
Compared with the prior art, the invention has the beneficial effects that: the invention adopts the full membrane process of ceramic membrane and organic membrane, not only separates and concentrates the heparin sodium in the main production process, but also carries out further membrane treatment and recovery on the traditional heparin sodium wastewater, thereby achieving the effects of saving energy consumption and improving the production efficiency of the heparin sodium. The energy consumption of drying can be reduced to 1/5-7 after membrane treatment.
Drawings
Fig. 1 is a schematic view of a flow structure of a ceramic membrane in a heparin sodium membrane integration process.
Fig. 2 is a schematic view of the flow structure of an organic membrane in a heparin sodium membrane integration process.
Fig. 3 is a schematic diagram of a ceramic membrane structure in a heparin sodium membrane integration process.
Fig. 4 is a schematic view of an organic membrane structure in a heparin sodium membrane integration process.
Fig. 5 is a schematic structural diagram of a first circulation pump of a ceramic membrane in a heparin sodium membrane integration process.
In the figure: 1. a first circulation groove; 2. a first feeding pump; 3. a first security filter; 4. a first circulating pump; 5. a first membrane assembly; 6. a first pressure gauge; 7. a first thermometer; 101. a second circulation tank; 201. a second feeding pump; 301. a second security filter; 401. a second circulating pump; 501. a second membrane component; 601. a second pressure gauge; 801. a high pressure pump; 901. and adjusting the valve.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1 to 5, in an embodiment of the present invention, a heparin sodium membrane integration process includes filtering by a ceramic membrane device, and then filtering, separating and concentrating by an organic membrane device;
ceramic membrane filtration: primarily treating a heparin sodium intermediate product after salt decomposition and enzymolysis, wherein a ceramic ultrafiltration membrane is adopted as ceramic membrane equipment, the interception aperture is 50nm, macromolecular impurities such as protein are removed through a ceramic membrane to obtain a penetrating fluid, the penetrating fluid is a product containing heparin sodium and micromolecular salts, and the protein in a concentrated solution obtained by filtering through the ceramic membrane can be used as a fertilizer or a feed;
and (3) filtering and concentrating by using an organic membrane: the permeable liquid obtained by filtering the ceramic membrane has the interception aperture of 150-300DAL and contains heparin sodium, salt and water micromolecule substances, monovalent salt and water are removed by selecting the organic nanofiltration membrane, the content of the heparin sodium is purified, the heparin sodium can be concentrated to 5-7 times, the permeable liquid obtained by nanofiltration of the organic membrane contains salt and water which can be used as water for a preorder salt decomposition process, and the concentrated solution enters the next drying process.
The utility model provides a heparin sodium membrane integrated technology, ceramic membrane equipment include circulation groove 1, feed pump 2 and cartridge filter 3, the inlet tube of feed pump 2 links to each other with circulation groove 1, and the exit end links to each other with 4 entry flanges of circulating pump after cartridge filter 3, membrane module 5 import department sets up fast-assembling clamp connection circulating pump 4 exit ends, and partly backward flow of membrane module 5 concentrate pipe is to circulation groove 1 in partly backward flow to 4 entrances of circulating pump, and membrane module 5 infiltration side links to each other with the infiltration pipe through the clamp, discharges or retrieves the infiltration liquid, be equipped with thermometer 7 on the pipeline of 5 lower extremes of membrane module.
The heparin sodium membrane integration process is characterized in that the organic membrane equipment comprises a second circulation tank 101, a second feeding pump 201 and a second cartridge filter 301, the water inlet pipe of the second feeding pump 201 is connected with the second circulation tank 101, the outlet end of the second feeding pump is connected with the inlet flange of the second circulation pump 401 after passing through the second cartridge filter 301, the inlet of the second membrane module 501 is provided with a fast-assembling clamp connected with the outlet end of the second circulating pump 401, one part of the concentrated water pipe of the second membrane module 501 returns to the second circulating tank 101, the other part of the concentrated water pipe returns to the inlet of the second circulating pump 401, the permeation side of the second membrane module 501 is connected with the permeation pipe through the clamp, discharging or recycling penetrating fluid, respectively arranging a first pressure gauge 6 and a second pressure gauge 601 on pipelines at two ends of the first membrane module 5 and two ends of the second membrane module 501, a second high-pressure pump 801 is arranged on a pipeline of the second cartridge filter 301, and a second regulating valve 901 is arranged on a pipeline at one end of the second high-pressure pump 801.
When the method is used, the ceramic membrane and the organic membrane are mainly used for treating the traditional heparin sodium wastewater, so that the heparin sodium in the wastewater is recycled on one hand, and the organic membrane permeate water is recycled to the front stage salinization process for secondary utilization on the other hand.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (9)
1. A heparin sodium membrane integration process is characterized in that after being filtered by ceramic membrane equipment, the heparin sodium membrane integration process is filtered, separated and concentrated by organic membrane equipment;
ceramic membrane filtration: primarily treating the heparin sodium after salt decomposition and enzymolysis to remove macromolecular impurities such as protein through a ceramic membrane to obtain penetrating fluid which is a product containing heparin sodium and micromolecular salts;
and (3) filtering and concentrating by using an organic membrane: the penetrating fluid obtained by filtering the ceramic membrane contains heparin sodium, salt and water micromolecule substances, monovalent salt and water are removed by selecting an organic nanofiltration membrane, the content of the heparin sodium is purified, the heparin sodium can be concentrated to 5-7 times, the penetrating fluid obtained by nanofiltration of the organic membrane contains salt and water which can be used as water for a preorder salt decomposition process, and the concentrated solution enters the next drying process.
2. The heparin sodium membrane integrated process according to claim 1, wherein the ceramic membrane equipment adopts a ceramic ultrafiltration membrane, and the cutoff pore diameter is 50 nm.
3. The heparin sodium membrane integrated process according to claim 1, wherein the protein in the concentrated solution obtained by filtering with the ceramic membrane can be used as fertilizer or feed.
4. The integrated process of claim 1, wherein the organic nanofiltration membrane has a cutoff of 150-300 DAL.
5. The heparin sodium membrane integrated process according to claim 1, wherein the ceramic membrane equipment comprises a first circulation tank (1), a first feed pump (2) and a first security filter (3), a water inlet pipe of the first feed pump (2) is connected with the first circulation tank (1), an outlet end of the first feed pump is connected with an inlet flange of a first circulation pump (4) after passing through the first security filter (3), a fast-assembling clamp is arranged at an inlet of the first membrane module (5) and connected with an outlet end of the first circulation pump (4), a part of a concentrated water pipe of the first membrane module (5) returns to the first circulation tank (1), a part of the concentrated water pipe returns to an inlet of the first circulation pump (4), a permeation side of the first membrane module (5) is connected with a permeation pipe through the clamp, and a permeation liquid is discharged or recycled;
the heparin sodium membrane integration process according to claim 1, wherein the organic membrane equipment comprises a second circulation tank (101), a second feed pump (201) and a second security filter (301), a water inlet pipe of the second feed pump (201) is connected with the second circulation tank (101), an outlet end of the second feed pump (201) is connected with an inlet flange of the second circulation pump (401) after passing through the second security filter (301), a fast-assembling clamp is arranged at an inlet of the second membrane module (501) and connected with an outlet end of the second circulation pump (401), a part of a concentrated water pipe of the second membrane module (501) flows back to the second circulation tank (101), a part of the concentrated water pipe flows back to the inlet of the second circulation pump (401), and a permeation side of the second membrane module (501) is connected with a permeation pipe through a clamp to discharge or recover a permeation.
6. The heparin sodium membrane integration process according to claim 5, wherein a first pressure gauge (6) and a second pressure gauge (601) are respectively arranged on pipelines at two ends of the first membrane component (5) and two ends of the second membrane component (501).
7. The heparin sodium membrane integrated process according to claim 5, wherein a first thermometer (7) is arranged on a pipeline at the lower end of the first membrane component (5).
8. The heparin sodium membrane integration process according to claim 6, wherein a second high-pressure pump (801) is arranged on a pipeline of the second cartridge filter (301).
9. The heparin sodium membrane integration process according to claim 9, wherein a second regulating valve (901) is arranged on a pipeline at one end of the second high-pressure pump (801).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010663833.1A CN111888941A (en) | 2020-07-10 | 2020-07-10 | Heparin sodium membrane integration process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010663833.1A CN111888941A (en) | 2020-07-10 | 2020-07-10 | Heparin sodium membrane integration process |
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| Publication Number | Publication Date |
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| CN111888941A true CN111888941A (en) | 2020-11-06 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202010663833.1A Pending CN111888941A (en) | 2020-07-10 | 2020-07-10 | Heparin sodium membrane integration process |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113061199A (en) * | 2021-04-13 | 2021-07-02 | 重庆博万生物制药有限公司 | Process for concentrating and extracting crude heparin sodium by using nanofiltration membrane |
| CN115368487A (en) * | 2022-05-07 | 2022-11-22 | 巴彦淖尔海成生物科技有限公司 | High-efficiency environment-friendly extraction method of crude heparin sodium by taking lungs of pigs, cattle and sheep as raw materials |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104072636A (en) * | 2014-06-25 | 2014-10-01 | 江苏久吾高科技股份有限公司 | Preparation technique of heparin sodium |
| CN106380527A (en) * | 2016-11-15 | 2017-02-08 | 如皋市坝新肠衣有限公司 | Device for preparing heparin sodium by concentrating multilevel special resin |
-
2020
- 2020-07-10 CN CN202010663833.1A patent/CN111888941A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104072636A (en) * | 2014-06-25 | 2014-10-01 | 江苏久吾高科技股份有限公司 | Preparation technique of heparin sodium |
| CN106380527A (en) * | 2016-11-15 | 2017-02-08 | 如皋市坝新肠衣有限公司 | Device for preparing heparin sodium by concentrating multilevel special resin |
Non-Patent Citations (1)
| Title |
|---|
| 唐婕等: "《环保陶瓷生产与应用》", 中国建材工业出版社, pages: 144 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113061199A (en) * | 2021-04-13 | 2021-07-02 | 重庆博万生物制药有限公司 | Process for concentrating and extracting crude heparin sodium by using nanofiltration membrane |
| CN115368487A (en) * | 2022-05-07 | 2022-11-22 | 巴彦淖尔海成生物科技有限公司 | High-efficiency environment-friendly extraction method of crude heparin sodium by taking lungs of pigs, cattle and sheep as raw materials |
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