CN111888284B - 化妆品组合物 - Google Patents
化妆品组合物 Download PDFInfo
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- CN111888284B CN111888284B CN202010788096.8A CN202010788096A CN111888284B CN 111888284 B CN111888284 B CN 111888284B CN 202010788096 A CN202010788096 A CN 202010788096A CN 111888284 B CN111888284 B CN 111888284B
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- KQVJZDZLEDQCSD-UHFFFAOYSA-H dialuminum;2-[[4-[ethyl-[(3-sulfonatophenyl)methyl]amino]phenyl]-[4-[ethyl-[(3-sulfonatophenyl)methyl]azaniumylidene]cyclohexa-2,5-dien-1-ylidene]methyl]benzenesulfonate Chemical compound [Al+3].[Al+3].C=1C=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C(=CC=CC=2)S([O-])(=O)=O)C=CC=1N(CC)CC1=CC=CC(S([O-])(=O)=O)=C1.C=1C=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C(=CC=CC=2)S([O-])(=O)=O)C=CC=1N(CC)CC1=CC=CC(S([O-])(=O)=O)=C1.C=1C=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C(=CC=CC=2)S([O-])(=O)=O)C=CC=1N(CC)CC1=CC=CC(S([O-])(=O)=O)=C1 KQVJZDZLEDQCSD-UHFFFAOYSA-H 0.000 claims description 12
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Abstract
本文描述的是亲和性的、在审美学上有吸引力、在唇部上不淤积、容易铺展开并且使唇部保湿的口红组合物。组合物包含化妆品成分如调理剂、保湿剂、抗氧化剂、结构化剂、乳化剂、含硅酮的化合物、精油、增稠剂、防腐剂和着色剂。
Description
本申请为2015年7月13日提交的申请号为201510408899.5的名称为“化妆品组合物”的申请的分案申请。
技术领域
本发明一般涉及基于唇部的组合物,例如口红。具体地,本发明涉及具有使唇部着色和保湿的能力的基于唇部的组合物。
背景技术
以前关于基于唇部的产品如口红和唇膏的尝试工作或者缺乏亲和性,易于在唇部干燥和结块或开裂;或缺乏有效处理或预防与唇部相关的状态(例如干燥或开裂的唇部、唇纹等)的能力。解决这些问题的尝试工作已经导致难以在唇部铺展开、具有令人不舒服的触觉特性(例如厚重、油腻、发粘等)、并且对于与唇部相关的状态具有有限的有益效果的制剂。这导致具有不良的审美学外观和有条纹/不均匀着色的唇部。
发明内容
本公开内容通过提供亲和性的、在审美学上吸引人的、在唇部不淤积、易于铺展开并且使唇部保湿的口红组合物来克服本领域中的缺陷。另外,成分的组合为口红组合物提供了均匀的颜色和一致性。
本公开的方面涉及包含带颜色的颗粒、司拉氯铵水辉石、聚羟基硬脂酸、和极性活化剂的组合物,其中带颜色的颗粒均匀分散在整个组合物中。替代地或者另外地,所述成分中的一种或任意组合可以用于本文描述的组合物中。在一些实施方案中,组合物可以包含0.01重量%至0.1重量%的司拉氯铵水辉石、0.001重量%至0.1重量%的聚羟基硬脂酸、和0.001重量%至0.1重量%的极性活化剂。在一些实施方案中,极性活化剂可以是碳酸亚丙酯。在一些实施方案中,组合物还可以包含增加组合物的可混合性的微球。在一些实施方案中,微球可以包含HDI/三羟甲基己基内酯交联聚合物和二氧化硅。在一些实施方案中,组合物可以包含0.5重量%至15重量%的HDI/三羟甲基己基内酯交联聚合物和二氧化硅。在一些实施方案中,带颜色的颗粒可以包括着色剂。在一些实施方案中,着色剂可以选自蓝1色淀、红6色淀、红色7色淀、黄5色淀、铁氧化物、二氧化钛、氧化锡和云母。在一些实施方案中,着色剂是本文中描述的着色剂。在一些实施方案中,组合物还可以包含向日葵(Helianthusannus)籽油、季戊四醇四异硬脂酸酯、双-二甘油多酰基己二酸酯-2、异壬酸异壬酯、聚乙烯、霍霍巴(Simmondsia chinensis)脂、云母、地蜡、蔗糖多大豆油酸酯、微晶蜡/无定形蜡和HDI/三羟甲基己基内酯交联聚合物。在一些实施方案中,组合物包含3重量%至15重量%的向日葵籽油、1重量%至15重量%的季戊四醇四异硬脂酸酯、7重量%至13重量%的双-二甘油多酰基己二酸酯-2、7重量%至13重量%的异壬酸异壬酯、2重量%至8重量%的聚乙烯、3重量%至7重量%的霍霍巴脂、3重量%至15重量%的云母、1重量%至4重量%的地蜡、1重量%至6重量%的蔗糖多大豆油酸酯、1重量%至6重量%的二氧化硅、0.1重量%至4重量%的微晶蜡/无定形蜡和0.5重量%至15重量%的HDI/三羟甲基己基内酯交联聚合物。
在一些实施方案中,组合物还可以包含三异硬脂醇柠檬酸酯。在一些实施方案中,组合物可以包含7重量%至13重量%的三异硬脂醇柠檬酸酯。在一些实施方案中,组合物可以包含1重量%至3重量%的HDI/三羟甲基己基内酯交联聚合物。
在一些实施方案中,组合物还可以包含聚甘油-10五异硬脂酸酯、甘油山嵛酸酯/二十酸酯、肉豆蔻酸异丙酯和醋酸生育酚酯。在一些实施方案中,组合物可以包含2重量%至10重量%的聚甘油-10五异硬脂酸酯、0.1重量%至3重量%的甘油山嵛酸酯/二十酸酯、0.1重量%至3重量%的肉豆蔻酸异丙酯和0.1重量%至3重量%的醋酸生育酚酯。在一些实施方案中,组合物可以包含2重量%至6重量%的HDI/三羟甲基己基内酯交联聚合物。
在一些实施方案中,组合物还可以包含甲基硅倍半氧烷。在一些实施方案中,组合物包含9重量%至13重量%的HDI/三羟甲基己基内酯交联聚合物。
在一些实施方案中,组合物还可以包含聚甘油-2二异硬脂酸酯/IPDI共聚物、三异硬脂醇柠檬酸酯、二(PPG-3肉豆蔻基醚)己二酸酯、和氢化聚异丁烯。在一些实施方案中,组合物可以包含8重量%至15重量%的聚甘油-2二异硬脂酸酯/IPDI共聚物、6重量%至12重量%的三异硬脂醇柠檬酸酯、2重量%至10重量%的二(PPG-3肉豆蔻基醚)己二酸酯、和2重量%至8重量%的氢化聚异丁烯。在一些实施方案中,组合物可以包含0.5重量%至3重量%的HDI/三羟甲基己基内酯交联聚合物。
在一些实施方案中,组合物还可以包含选自一种或更多种着色剂、填充剂、增稠剂、乳化剂、芳香剂、保湿剂、调理剂和/或抗氧化剂的一种或更多种另外的成分。在一些实施方案中,组合物可以配制成乳霜、精华、凝胶或软膏。在一些实施方案中,组合物可以是半固体。
本公开的其它方面涉及包含如下成分的组合物:蓖麻(Ricinus communis)籽油、油酸油醇酯、蜂蜡、小烛树(Euphorbia cerifera)蜡、地蜡、棕榈(Copernicia cerifera)蜡、甲基葡糖倍半硬脂酸酯和皮肤病学上可接受的载剂。在一些实施方案中,口红可以包含10重量%至60重量%的蓖麻籽油、5重量%至15重量%的油酸油醇酯、1重量%至10重量%的蜂蜡、1重量%至10重量%的小烛树蜡、1重量%至10重量%的地蜡、0.5重量%至5重量%的棕榈蜡、和0.5重量%至5重量%的甲基葡糖倍半硬脂酸酯。在一些实施方案中,口红还可以包含选自铁氧化物、二氧化钛、氢氧化铝、红7色淀、蓝1色淀、红27色淀和红6色淀的一种或更多种着色剂。在一些实施方案中,口红还可以包括选自一种或更多种调理剂、填充剂、调味剂、抗氧化剂和保湿剂的一种或更多种另外的成分。
本公开的其它方面涉及包含以下成分的口红组合物:向日葵油、季戊四醇四异硬脂酸酯、HDI/三羟甲基己基内酯交联聚合物、二氧化硅、云母、双-二甘油多酰基己二酸酯-2、霍霍巴(脂、聚乙烯、地蜡、微晶蜡、甘油山嵛酸酯/二十酸酯和皮肤病学上可接受的载剂。或者,所述成分中的一种或任意组合可以用于本文中描述的组合物。在一些实施方案中,向日葵油可以是混合油。在一些实施方案中,向日葵油可以是包含亚油酸的混合油。这样的混合油具有低于其它油酸向日葵油的单不饱和水平。在一些实施方案中,口红可以包含10重量%至20重量%的向日葵油、10重量%至20重量%的季戊四醇四异硬脂酸酯、10重量%至20重量%的HDI/三羟甲基己基内酯交联聚合物和二氧化硅的混合物、5重量%至15重量%的云母、5重量%至15重量%的双-二甘油多酰基己二酸酯-2、2重量%至8重量%的霍霍巴脂、2重量%至8重量%的聚乙烯、1重量%至5重量%的地蜡、0.1重量%至3重量%的微晶蜡、和0.1重量%至3重量%的甘油山嵛酸酯/二十酸酯。在一些实施方案中,口红还可以包含选自一种或更多种调理剂、保湿剂和着色剂的一种或更多种另外的成分。
本公开的其它方面涉及包含以下成分的组合物:棕榈酸乙基己酯、三山嵛精、失水山梨醇异硬脂酸酯、棕榈酰低聚肽和皮肤病学上可接受的载剂。替代地或另外地,所述成分中的一种或任意组合可以用于本文描述的组合物。在一些实施方案中,组合物可以包含0.1重量%至2重量%的棕榈酸乙基己酯、0.01重量%至1重量%的三山嵛精、0.001重量%至0.01重量%的失水山梨醇异硬脂酸酯、和0.0005重量%至0.01重量%的棕榈酰低聚肽。在一些实施方案中,组合物还可以包含蓖麻籽油、霍霍巴酯、向日葵籽油、澳洲坚果油酸乙酯、小烛树蜡、芒果(Mangifera indica)籽油、云母、白池花(Limnanthes alba)籽油、蜂蜡、向日葵籽蜡、蔗糖乙酸异丁酸酯和甜橙(Citrus aurantium dulcis)果皮蜡。在一些实施方案中,组合物可以包含25重量%至40重量%的蓖麻籽油、7重量%至15重量%的霍霍巴酯、7重量%至15重量%的向日葵籽油、3重量%至8重量%的澳洲坚果油酸乙酯、3重量%至8重量%的小烛树蜡、3至8重量%的芒果籽油、3重量%至8重量%的云母、白池花籽油、2重量%至7重量%的蜂蜡、2重量%至7重量%的向日葵籽蜡、2重量%至7重量%的蔗糖乙酸异丁酸酯和0.3重量%至3重量%的甜橙(Citrus aurantium dulcis)果皮蜡。在一些实施方案中,组合物还可以包含选自铁氧化物、氧化锡、氢氧化铝、红7色淀、蓝1色淀、黄5色淀和红6色淀的一种或更多种着色剂。在一些实施方案中,组合物还可以包含本文中描述的一种或更多种着色剂。在一些实施方案中,组合物还可以包含选自一种或更多种调理剂、含硅酮的化合物、抗氧化剂、pH调节剂、增稠剂、调味剂、结构化剂和保湿剂的一种或更多种另外的成分。在一些实施方案中,组合物是半固体。
本公开的方面涉及包含以下成分的口红组合物:向日葵籽油、季戊四醇四异硬脂酸酯、双-二甘油多酰基己二酸酯-2、HDI/三羟甲基己基内酯交联聚合物、云母、异壬酸异壬酯、霍霍巴脂、聚乙烯、二氧化硅、甲基硅倍半氧烷和皮肤病学上可接受的载剂。或者,所述成分中的一种或任意组合可以用于本文描述的组合物中。在一些实施方案中,口红可以包含10重量%至15重量%的向日葵籽油、10重量%至15重量%的季戊四醇四异硬脂酸酯、10重量%至15重量%的双-二甘油多酰基己二酸酯-2、8重量%至14重量%的HDI/三羟甲基己基内酯交联聚合物和甲基硅倍半氧烷的混合物、8重量%至14重量%的云母、7重量%至12重量%的异壬酸异壬酯、5重量%至10重量%的霍霍巴脂、2重量%至8重量%的聚乙烯、和2重量%至8重量%的二氧化硅。在一些实施方案中,口红还可以包含选自铁氧化物、红7色淀、蓝1色淀和红6色淀的一种或更多种着色剂。在其它实施方案中,口红还可以包含选自一种或更多种增稠剂、保湿剂、和调理剂的一种或更多种另外的成分。
本发明的其它方面涉及包含以下成分的口红组合物:聚甘油-2二异硬脂酸酯/IPDI共聚物、双-二甘油多酰基己二酸酯-2、三异硬脂醇柠檬酸酯、异壬酸异壬酯、聚乙烯、二(PPG-3肉豆蔻基醚)己二酸酯、向日葵籽油、霍霍巴脂、云母、氢化聚异丁烯、季戊四醇四异硬脂酸酯、地蜡、和皮肤病学上可接受的载剂。或者,所述成分中的一种或任意组合可以用于本文描述的组合物。在一些实施方案中,口红可以包含10重量%至20重量%的聚甘油-2二异硬脂酸酯/IPDI共聚物、10重量%至20重量%的双-二甘油多酰基己二酸酯-2、5重量%至15重量%的三异硬脂醇柠檬酸酯、5重量%至15重量%的异壬酸异壬酯、1重量%至10重量%的聚乙烯、1重量%至10重量%的二(PPG-3肉豆蔻基醚)己二酸酯、1重量%至10重量%的向日葵籽油、1重量%至10重量%的霍霍巴脂、1重量%至10重量%的云母、1重量%至10重量%的氢化聚异丁烯、1重量%至10重量%的季戊四醇四异硬脂酸酯和1重量%至10重量%的地蜡。在一些实施方案中,口红组合物还可以包含选自铁氧化物、红7色淀、蓝1色淀、黄5色淀和红6色淀中的一种或更多种着色剂。在一些实施方案中,口红组合物还可以包含选自一种或更多种调理剂、含硅酮的化合物、成膜剂、增稠剂、芳香剂、结构化剂和保湿剂中的一种或更多种另外的成分。
本文中任意方面和实施方案中所描述的组合物和口红可以配制成乳霜、精华、凝胶或软膏。在一些实施方案中,本文中所描述的组合物和口红可以为半固体的形式。在一些实施方案中,本文中所描述的组合物和口红是无水的。在一些实施方案中,本文中所描述的组合物和口红可以包含皮肤病学上可接受的载剂。皮肤病学上可接受的载剂可以是本文中描述的和/或本领域已知的任意皮肤病学上可接受的载剂。在一些实施方案中,皮肤病学上可接受的载剂可以是润肤剂。
本文中所描述的口红可以每天施用至少一次、两次、三次、四次或更多次。在施用之后,口红可以在皮肤上保留至少10、20、30或60分钟、1、2、3、4、5、6、7、8、9、10、11或12小时或更长的时间。口红还可以包括本说明书中所公开的化妆品和/或药学成分中的任一种或任意组合。例如,组合物可以包含选自以下类别中的至少一种、两种、三种、四种、五种、六种、七种、八种、九种和或十种的成分:
(1)紫外吸收剂;(2)保湿剂;(3)抗氧化剂;(4)结构化剂;(5)乳化剂;(6)含硅酮的化合物;(7)精油;(8)增稠剂;(9)防腐剂;和/或(10)调理剂。这类成分的量可以是以组合物的重量或体积计的0.0001%至99.9%,或者是在如本说明书其它章节中所公开的范围之间的任何整数或范围。
还预期可以选择口红组合物的黏度以实现期望的结果(例如,根据期望的组合物的类型,这样的组合物的黏度可以为约1厘泊至远超过1百万厘泊,或为其中可导出的任意范围或整数值(例如,如在25℃下以2.5转/分钟利用TC轴在Brookfield黏度计上测量的2厘泊,3、4、5、6、7、8、9、10、20、30、40、50、60、70、80、90、100、200、300、400、500、600、700、800、900、1000、2000、3000、4000、5000、6000、7000、8000、9000、10000、20000、30000、40000、50000、60000、70000、80000、90000、100000、200000、300000、400000、500000、600000、700000、800000、900000、1000000厘泊等,)。在非限制性方面,组合物可以具有约6至约9的pH值。在其它方面,pH可以是1、2、3、4、5、6、7、8、9、10、11、12、13或14。在其它方面,组合物可以是具有1、5、10、15、20、25、30、35、40、45、50、55或更大的防晒指数(SPF)的防晒霜。
口红可以具有在化妆上或在药学上优良的触感,例如在施用至皮肤如手部皮肤之后不油、不腻、非粘性、不发粘和/或丝般感觉。
还公开了一种用于使唇部着色、润使唇部、处理干燥的、破裂的或皲裂的唇部或唇红缘的皮肤或者预防或减少唇部皱纹或唇红缘皱纹、或唇红缘红斑(即,红色或发炎的皮肤)出现的方法,包括对干燥的、破裂的或皲裂的唇部或者需要预防或者减少唇部皱纹的唇部局部施用本申请所公开的口红中的任一种或本申请所公开的混合物中的任一种,其中组合物或混合物的局部施用使唇部着色、保湿、处理干燥的、破裂的或皲裂的唇部或预防或减少唇部皱纹的出现。所述组合物可以直接施用到唇部上,或可以施用到已经施用过口红或润唇膏的唇部上。基于唇部的组合物还可以用于通过将组合物局部施用到需要增加胶原蛋白生成和透明质酸生成的唇部来增加唇部中的胶原蛋白和透明质酸的生成。
在本发明的情况下还公开了实施方案1至25。实施方案1是包含以下成分的组合物:带颜色的颗粒、司拉氯铵水辉石、聚羟基硬脂酸和极性活化剂,其中所述带颜色的颗粒均匀分散在整个组合物中。实施方案2是实施方案1的组合物,其中所述组合物包含0.01重量%至0.1重量%的的司拉氯铵水辉石;0.001重量%至0.1重量%的聚羟基硬脂酸;和0.001重量%至0.1重量%的极性活化剂。实施方案3是实施方案1或2的组合物,其中所述极性活化剂是碳酸亚丙酯。实施方案4是实施方案1-3中任一项的组合物,其中所述组合物还包含增加所述组合物的可混合性的微球。实施方案5是实施方案4的组合物,所述微球包含HDI/三羟甲基己基内酯交联聚合物和二氧化硅。实施方案6是实施方案5的组合物,其中所述组合物包含0.5重量%至15重量%的HDI/三羟甲基己基内酯交联聚合物和二氧化硅。实施方案7是实施方案1-6中任一项的组合物,其中所述组合物还包含:向日葵籽油、季戊四醇四异硬脂酸酯、三异硬脂醇柠檬酸酯、双-二甘油多酰基己二酸酯-2、异壬酸异壬酯、聚乙烯、霍霍巴脂、云母、地蜡、蔗糖多大豆油酸酯、二氧化硅、微晶蜡/无定形蜡、和HDI/三羟甲基己基内酯交联聚合物。实施方案8是实施方案7的组合物,其中所述组合物包含3重量%至15重量%的向日葵籽油、1重量%至15重量%的季戊四醇四异硬脂酸酯、7重量%至13重量%的双-二甘油多酰基己二酸酯-2、7重量%至13重量%的异壬酸异壬酯、2重量%至8重量%的聚乙烯、3重量%至7重量%的霍霍巴脂、3重量%至15重量%的云母、1至4重量%的地蜡、1至6重量%的蔗糖多大豆油酸酯、1重量%至6重量%的二氧化硅、0.1重量%至4重量%的微晶蜡/无定形蜡和0.5重量%至15重量%的HDI/三羟甲基己基内酯交联聚合物。实施方案9是实施方案1-8中任一项所述的组合物,其中所述带颜色的颗粒包含着色剂。实施方案10是实施方案9的组合物,其中所述着色剂选自蓝1色淀、红6色淀、红7色淀、黄5色淀、铁氧化物、二氧化钛、氧化锡和云母。
实施方案11是实施方案1-10中任一项所述的组合物,其中所述组合物还包含三异硬脂醇柠檬酸酯。实施方案12是实施方案11的组合物,其中所述组合物还包含7重量%至13重量%的三异硬脂醇柠檬酸酯。实施方案13是实施方案1-12中任一项所述的组合物,其中所述组合物包含或还包含1重量%至3重量%的HDI/三羟甲基己基内酯交联聚合物。
实施方案14是实施方案1-13中任一项所述的组合物,其中所述组合物还包含聚甘油-10五异硬脂酸酯、甘油山嵛酸酯/二十酸酯、肉豆蔻酸异丙酯和醋酸生育酚酯。实施方案15是实施方案14所述的组合物,其中所述组合物包含2重量%至10重量%的聚甘油-10五异硬脂酸酯、0.1重量%至3重量%的甘油山嵛酸酯/二十酸酯、0.1重量%至3重量%的肉豆蔻酸异丙酯和0.1重量%至3重量%的醋酸生育酚酯。实施方案16是实施方案1-15中任一项所述的组合物,其中所述组合物包含或还包含2重量%至6重量%的HDI/三羟甲基己基内酯交联聚合物。
实施方案17是实施方案1-16中任一项所述的组合物,其中所述组合物还包含甲基硅倍半氧烷。实施方案18是实施方案1-17中任一项所述的组合物,其中所述组合物包含或还包含9重量%至13重量%的HDI/三羟甲基己基内酯交联聚合物。
实施方案19是实施方案1-18中任一项所述的组合物,其中所述组合物还包含聚甘油-2二异硬脂酸酯/IPDI共聚物、三异硬脂醇柠檬酸酯、二(PPG-3肉豆蔻基醚)己二酸酯和氢化聚异丁烯。实施方案20是实施方案19所述的组合物,其包含8重量%至15重量%的聚甘油-2二异硬脂酸酯/IPDI共聚物、6重量%至12重量%的三异硬脂醇柠檬酸酯、2重量%至10重量%的二(PPG-3肉豆蔻基醚)己二酸酯和2重量%至8重量%的氢化聚异丁烯。实施方案21是实施方案1-20中任一项所述的组合物,其中所述组合物包含或还包含0.5重量%至3重量%的HDI/三羟甲基己基内酯交联聚合物。
实施方案22是实施方案1-21中任一项所述的组合物,其中所述组合物是无水的。实施方案23是实施方案1-22中任一项所述的组合物,其中所述组合物还包含选自一种或更多种着色剂、填充剂、增稠剂、乳化剂、芳香剂、保湿剂、调理剂和抗氧化剂的一种或更多种另外的成分。实施方案24是实施方案1-23中任一项所述的组合物,其中所述组合物配制成乳霜、精华、凝胶或软膏。实施方案25是实施方案1-24中任一项所述的组合物,其中所述组合物是半固体的。
在本公开的上下文中还公开了实施方案26至33。实施方案26是口红,其包含蓖麻籽油、油酸油醇酯、蜂蜡、小烛树蜡、地蜡、棕榈蜡、甲基葡糖倍半硬脂酸酯、和皮肤病学上可接受的载剂。实施方案27是实施方案26的口红,其中所述口红是无水的。实施方案28是实施方案26或27的口红,其中所述皮肤病学上可接受的载剂是润肤剂。实施方案29是实施方案26-28中任一项所述的口红,其包含10重量%至60重量%的蓖麻籽油、5重量%至15重量%的油酸油醇酯、1重量%至10重量%的蜂蜡、1重量%至10重量%的小烛树蜡、1重量%至10重量%的地蜡、0.5重量%至5重量%的棕榈蜡、和0.5重量%至5重量%的甲基葡糖倍半硬脂酸酯。实施方案30是实施方案26-29中任一项所述的口红,其还包含选自铁氧化物、二氧化钛、氢氧化铝、红7色淀、蓝1色淀、红27色淀和红6色淀的一种或更多种着色剂。实施方案31是实施方案26-30中任一项所述的口红,其还包含选自一种或更多种调理剂、填充剂、调味剂、抗氧化剂和保湿剂的一种或更多种另外的成分。实施方案32是实施方案26-31中任一项所述的口红,其中所述口红配制成乳霜、精华、凝胶或软膏。实施方案33是实施方案26-32中任一项所述的口红,其中所述口红是半固体的。
在本公开的上下文中还公开了实施方案34至41。实施方案34是口红,其包含向日葵油、季戊四醇四异硬脂酸酯、HDI/三羟甲基己基内酯交联聚合物、二氧化硅、云母、双-二甘油多酰基己二酸酯-2、霍霍巴脂、聚乙烯、地蜡、微晶蜡、甘油山嵛酸酯/二十酸酯、和皮肤病学上可接受的载剂。实施方案35是实施方案34所述的口红,其中所述口红是无水的。实施方案36是实施方案34或35所述的口红,其中所述皮肤病学上可接受的载剂是润肤剂。实施方案37是实施方案34-36中任一项所述的口红,其中所述向日葵油是混合油。实施方案38是实施方案34-37中任一项所述的口红,其包含10重量%至20重量%的向日葵油、10重量%至20重量%的季戊四醇四异硬脂酸酯、10重量%至20重量%的HDI/三羟甲基己基内酯交联聚合物和二氧化硅的混合物、5重量%至15重量%的云母、5重量%至15重量%的双-二甘油多酰基己二酸酯-2、2重量%至8重量%的霍霍巴脂、2重量%至8重量%的聚乙烯、1重量%至5重量%的地蜡、0.1重量%至3重量%的微晶蜡、和0.1重量%至3重量%的甘油山嵛酸酯/二十酸酯。实施方案39是实施方案34-38中任一项所述的口红,其还包含选自一种或更多种调理剂、保湿剂和着色剂的一种或更多种另外的成分。实施方案40是实施方案34-39中任一项所述的口红,其中所述口红配制成乳霜、精华、凝胶或软膏。实施方案41是实施方案34-40中任一项所述的口红,其中所述口红是半固体的。
在本公开的上下文中还公开了实施方案42至51。实施方案42是组合物,其包含:棕榈酸乙基己酯、三山嵛精、失水山梨醇异硬脂酸酯、棕榈酰低聚肽、和皮肤病学上可接受的载剂。实施方案43是实施方案42所述的组合物,其中所述组合物包含0.1重量%至2重量%的棕榈酸乙基己酯、0.01重量%至1重量%的三山嵛精、0.001重量%至0.01重量%的失水山梨醇异硬脂酸酯、和0.0005重量%至0.01重量%的棕榈酰低聚肽。实施方案44是实施方案42或43所述的组合物,其中所述组合物还包含蓖麻籽油、霍霍巴酯、向日葵籽油、澳洲坚果油酸乙酯、小烛树蜡、芒果籽脂、云母、白池花籽油、蜂蜡、向日葵籽蜡、蔗糖乙酸异丁酸酯、和甜橙果皮蜡。实施方案45是实施方案44所述的组合物,其中所述组合物包含25重量%至40重量%的蓖麻油、7重量%至15重量%的荷荷巴酯、7重量%至15重量%的向日葵籽油、3重量%至8重量%的澳洲坚果油酸乙酯、3重量%至8重量%的小烛树蜡、3重量%至8重量%的芒果籽脂、3重量%至8重量%的云母、3至8重量%的白池花籽油、2至7重量%的蜂蜡、2重量%至7重量%的向日葵籽蜡、2重量%至7重量%的蔗糖乙酸异丁酸酯和0.3至3重量%的甜橙果皮蜡。实施方案46是实施方案42-45中任一项所述的组合物,其中所述组合物是无水的。实施方案47是实施方案42-46中任一项所述的组合物,其中所述皮肤病学上可接受的载剂是润肤剂。实施方案48是实施方案42-47中任一项所述的组合物,其还包含选自铁氧化物、氧化锡、氢氧化铝、红7色淀、蓝1色淀、黄5色淀和红6色淀的一种或更多种着色剂。实施方案49是实施方案42-48中任一项所述的组合物,其中所述组合物还包含选自一种或更多种调理剂、含硅酮的化合物、抗氧化剂、pH调节剂、增稠剂、调味剂、结构化剂和保湿剂的一种或更多种另外的成分。实施方案50是实施方案42-49中任一项所述的组合物,其中所述组合物配制成乳霜、精华、凝胶或软膏。实施方案51是实施方案42-50中任一项所述的组合物,其中所述组合物是半固体的。
在本公开的上下文中还公开了实施方案52至59。实施方案52是口红,其包含向日葵籽油、季戊四醇四异硬脂酸酯、双-二甘油多酰基己二酸酯-2、HDI/三羟甲基己基内酯交联聚合物、云母、异壬酸异壬酯、霍霍巴脂、聚乙烯、二氧化硅、甲基葡糖倍半硬脂酸酯和皮肤病学上可接受的载剂。实施方案53是实施方案52的口红,其中所述口红是无水的。实施方案54是实施方案52或53所述的口红,其中所述皮肤病学上可接受的载剂是润肤剂。实施方案55是实施方案52至54中任一项所述的口红,其包含10重量%至15重量%的向日葵籽油、10重量%至15重量%的季戊四醇四异硬脂酸酯、10重量%至15重量%的双-二甘油多酰基己二酸酯-2、8重量%至14重量%的HDI/三羟甲基己基内酯交联聚合物和甲基葡糖倍半硬脂酸酯的混合物、8重量%至14重量%的云母、7重量%至12重量%的异壬酸异壬酯、5重量%至10重量%的霍霍巴脂、2重量%至8重量%的聚乙烯、和2重量%至8重量%的二氧化硅。实施方案56是实施方案52-55中任一项所述的口红,其还包含选自铁氧化物、红7色淀、蓝1色淀和红6色淀的一种或更多种着色剂。实施方案57是实施方案52-56中任一项所述的口红,其还包含选自一种或更多种增稠剂、保湿剂和调理剂的一种或更多种另外的成分。实施方案58是实施方案52-57中任一项所述的口红,其中所述口红配制成乳霜、精华、凝胶或软膏。实施方案59是实施方案52-58中任一项所述的口红,其中所述口红是半固体的。
在本公开的上下文中还公开了实施方案60至67。实施方案60是口红,其包含聚甘油-2二异硬脂酸酯/IPDI共聚物、双-二甘油多酰基己二酸酯-2、三异硬脂醇柠檬酸酯、异壬酸异壬酯、聚乙烯、二(PPG-3肉豆蔻基醚)己二酸酯、向日葵籽油、霍霍巴脂、云母、氢化聚异丁烯、季戊四醇四异硬脂酸酯、地蜡、和皮肤病学上可以接受的载剂。实施方案61是实施方案60的口红,其中所述口红是无水的。实施方案62是实施方案60或61所述的口红,其中所述皮肤病学上可以接受的载剂是润肤剂。实施方案63是实施方案60-62中任一项所述的口红,其包含10重量%至20重量%的聚甘油-2二异硬脂酸酯/IPDI共聚物、10重量%至20重量%的双-二甘油多酰基己二酸酯-2、5重量%至15重量%的三异硬脂醇柠檬酸酯、5重量%至15重量%的异壬酸异壬酯、1重量%至10重量%的聚乙烯、1重量%至10重量%的二(PPG-3肉豆蔻基醚)己二酸酯、1重量%至10重量%的向日葵籽油、1重量%至10重量%的霍霍巴脂、1重量%至10重量%的云母、1重量%至10重量%的氢化聚异丁烯、1重量%至10重量%的季戊四醇四异硬脂酸酯、和1重量%至10重量%的地蜡。实施方案64是实施方案60-63中任一项所述的口红,其还包含选自铁氧化物、红7色淀、蓝1色淀、黄5色淀和红6色淀的一种或更多种着色剂。实施方案65是实施方案60-64中任一项所述的口红,其还包含选自一种或更多种调理剂、含硅酮的化合物、成膜剂、增稠剂、芳香剂、结构化剂和保湿剂的一种或更多种另外的成分。实施方案66是实施方案60-65中任一项所述的口红,其中所述口红配制成乳霜、精华、凝胶或软膏。实施方案67是实施方案60-66中任一项所述的口红,其中所述口红是半固体的。
在本公开的上下文中还公开了实施方案68,其涉及用于使唇部着色或保湿的方法,包括将实施方案1-67中任一项所述的口红或组合物施用至唇部。
还预期包含本说明书和权利要求全文所公开的组合物中的任何一种的试剂盒。在某些实施方案中,组合物被包含在容器中。该容器可以是瓶子、分配器或小型施用器。该容器可以分配预定量的组合物。在某些方面,组合物形成为棒状物并容纳在用以维持组合物的结构并用以将组合物施用至唇部的壳体中。在其它方面,口红组合物处于分配器中,分配器包括用于将口红施用至唇部的施用器。该容器可以在其表面上包含标记。该标记可以是单词、缩写、图片或符号。
还预期了一种包含本发明的组合物的产品。在非限制性方面,该产品可以是化妆品。该化妆品可以是本说明书其它章节所述的那些,或是本领域技术人员已知的那些。产品的非限制性实例包括保湿霜、乳霜、润肤露、柔肤水、粉底、晚霜、口红、清洁剂、爽肤水、防晒霜、面膜、抗老化产品。
该组合物及其使用方法可以“包含”说明书全文所公开成分的任一种,“主要由所述成分组成”或“由所述成分组成”。如本说明书和权利要求所使用的,单词“包含”、“具有”、“包括”或“含有”是包括性的或开放式的,并且不排除另外的、未列举的要素或方法步骤。
“主要由……组成”表示在组合物中包含另外的成分不实质上影响组合物的有益性能。例如,如果组合物“主要由带颜色的颗粒、司拉氯铵水辉石、聚羟基硬脂酸和极性活化剂组成”,则所述组合物不包括将会实质上影响组合物用于唇部着色、唇部保湿、处理干燥的、开裂的或皲裂的唇部或唇红缘中的皮肤或用于防止或减少唇纹或唇红缘中的皱纹的出现、或唇红缘中的红斑(即红色的或发炎的皮肤)的有益性能的任何成分。
预期的是本说明书中所讨论的任何实施方案可以针对本发明的任何方法或组合物来实施,反之亦然。此外,本发明的组合物可以用于实现本发明的方法。
在一个实施方案中,本发明的组合物可以是可药用的或可化妆用的,或可以具有舒适的触觉性质。“可药用的”、“可化妆用的”和/或“舒适的触觉性质”描述具有令皮肤感觉舒适的特定的触觉性质的组合物(例如,不是太水或太油的组合物、具有丝滑质地的组合物、不发粘或非黏性的组合物等)。可药用的或可化妆用的还可以涉及组合物的乳脂状或润滑性能,或组合物的水分保留性能。
“唇红缘”是指唇部(红色的)和相邻正常皮肤之间的通常尖锐的分界。其代表从高度角质化的外部皮肤至较少角质化的内部皮肤的变化。它没有皮脂腺、汗腺或毛发。
“局部施用”是指施用或涂敷组合物到唇部或角质组织的表面上。“局部皮肤用组合物”包含适合在唇部或角质组织局部施用的组合物。这类组合物一般为皮肤病学可接受的,这是因为当施用到唇部或皮肤时,其不具有异常毒性、不相容性、不稳定性、过敏反应等。本发明的局部护肤组合物可以具有选定的黏度以避免施用到皮肤后明显的滴落或淤积。
“角质组织”包含作为哺乳类最外保护层布置的含有角质的层,并且包含但不限于唇部、皮肤、毛发和指甲。
术语“大约”或“约”定义为如本领域普通技术人员所理解的接近于,并且在一个非限制性实施方案中该术语定义为在10%以内,优选在5%以内,更优选在1%以内,最优选在0.5%以内。
术语“基本上”及其变体定义为如本领域普通技术人员所理解的大部分但不一定为所指定的全部,并且在一个非限定性实施方案中基本上指的是范围在10%以内、在5%以内、在1%以内或在0.5%以内。
术语“抑制”或“减少”或这些术语的任何变体包括为了达到预期结果的任何可测量的减少或完全的抑制。术语“促进”或“增加”或这些术语的任何变体包括为了达到预期结果的蛋白质或分子(例如,基质蛋白如纤维粘连蛋白、层粘连蛋白、胶原蛋白或弹性蛋白,或者分子如透明质酸)的任何可测量的增加或产生。
作为本说明书和/或权利要求所使用的术语,术语“有效的”表示足以实现希望的、期望的或预期的结果。
本发明的其它目的、特征和优点通过下面的详细描述会变得明显。然而,应理解详细的描述和实施例在表明本发明的具体实施方案时仅以举例说明的方式给出。另外,期望通过该详细描述,本发明的精神和范围内的变化和修改对于本领域技术人员会变得明显。
具体实施方式
本文描述的组合物可以用于使皮肤和唇部保湿、着色、和/或处理或舒缓皮肤和唇部。本文所述的组合物也可以用于给予皮肤或唇部香味、光泽或保护性膜。在一些实施方案中,组合物配制为口红。
本文描述的组合物的实施方案包括具有均匀分散在整个组合物中的带颜色的颗粒的组合物。均匀的分散体包含司拉氯铵水辉石、聚羟基硬脂酸和聚活性剂的组合。这些成分的组合提供了成分的流变学控制和均匀的分散。
组合物的其它实施方案包括成分如棕榈酸乙基己酯、三山嵛精、失水山梨醇异硬脂酸酯和棕榈酰低聚肽的组合。棕榈酸乙基己酯来源于2-乙基己醇和棕榈酸的脂肪酸酯。它可用作溶剂、载剂、颜料润湿剂、香味固定剂和润肤剂。三山嵛精由甘油和山嵛酸制得,并且可用于调节皮肤。失水山梨醇异硬脂酸酯可用作组合物中的表面活性剂和乳化剂。棕榈酰低聚肽是赋予组合物抗老化性能的几种脂肪酸和氨基酸的混合物。它可以与皮肤的胶原蛋白相关并促进其生成,这是实现光滑的、无皱纹的皮肤的主要因素。
本文中描述的实施方案包括成分如HDI/三羟甲基己基内酯交联聚合物、二氧化硅和甲基葡糖倍半硬脂酸酯。这些成分以由Kobo Products Inc.公司(South Plainfield,新泽西州)以商品名BPD-500作为成分组合/单个成分销售。特别地,BDP-500是被认为散射光的微球,这消除了唇部上的细纹外观并且同时还使足够的光通过以使得唇部具有天然的视觉外观。
本文描述的口红组合物的其它实施方案的前提是发现了可用于唇部的保湿和着色的包含以下成分的组合:蜂蜡、小烛树蜡、地蜡、棕榈蜡和甲基葡糖倍半硬脂酸酯;或者包含以下成分的组合:聚乙烯、地蜡、微晶蜡和甘油山嵛酸酯/二十酸酯。在下文中更详细地讨论这些成分。
甲基葡糖倍半硬脂酸酯是来源于葡萄糖的乳化剂。它是来源于玉米或棕榈的甲基葡萄糖的硬脂酸酯。
甘油山嵛酸酯/二十酸酯是甘油与山嵛酸和二十烷酸的酯的混合物。它用作化妆品组合物中的润肤剂和乳化剂。
蜡构成用于制造个人护理产品和装饰性化妆品的重要成分种类。在化学上,蜡是与酯结合的脂肪酸和重烃的复杂混合物。蜡提供结构,相比其他结构化剂而言不油腻,并且非常耐受水分、氧化和微生物侵袭。
地蜡是在许多地区中发现的天然存在的有气味矿物蜡或石蜡。它为组合物有效地提供硬度、凝胶强度和稠度。它还确保颜色均匀性、具有乳化和润肤性能,并且与所有种类的矿物和植物油和蜡相容。
聚乙烯是用于化妆品组合物中的合成蜡。它是乙烯单体的聚合物,并且可以用作化妆品组合物中的乳化稳定剂、成膜剂和/或增黏剂。
蜂蜡(Cera Alba)是由蜜蜂产生来建造其蜂巢壁的天然蜡。蜂蜡是增稠剂。它使固体产品(例如口红)的油部分增稠、赋予其结构并且将它们保持为固体。它使眼化妆产品有刚性而不使它们硬化。它也是光滑和软化皮肤的润肤剂。
小烛树蜡来源于原生于墨西哥北部和美国西南部的小烛树灌木的部分的蜡。在一些实施方案中,该蜡来源于叶。它通常与其它蜡混合使用以使它们硬化而不升高其熔点。
棕榈蜡是从巴西热带棕榈树(Copernicia cerifera)获得。在一些实施方案中,它是从叶获得。该蜡帮助保持乳液不分离成其油和液体成分,并且还增加组合物的脂质部分的稠度,这赋予其结构和允许流畅地施用。棕榈蜡是市售植物蜡中最硬的。它是一种有韧性的、无定形的、有光泽的蜡,其颜色为深黄色至棕色、绿色或白色。该蜡有时被称为巴西蜡。
微晶蜡由混合的精炼烃构成。它比石蜡脆性小而延展性大。相比石蜡,微晶蜡还具有更大的亲油性,并且通常包含1-4%的矿物油。由于其保持高油量(比其它蜡更多)的能力,所以微晶蜡实际上可以用于所有类型的化妆品。微晶蜡尤其可用于唇膏和口红以防止“出汗”。
A.基于唇部的制剂
预期本发明的组合物可以包含本说明书全文所描述的任何化妆品成分或其任意组合。在组合物中任意成分的浓度可以变化。例如,在非限制性实施方案中,组合物在其最终形式中可以包含、主要由以下组分组成或由以下组分组成:例如至少大约0.0001%、0.0002%、0.0003%、0.0004%、0.0005%、0.0006%、0.0007%、0.0008%、0.0009%、0.0010%、0.0011%、0.0012%、0.0013%、0.0014%、0.0015%、0.0016%、0.0017%、0.0018%、0.0019%、0.0020%、0.0021%、0.0022%、0.0023%、0.0024%、0.0025%、0.0026%、0.0027%、0.0028%、0.0029%、0.0030%、0.0031%、0.0032%、0.0033%、0.0034%、0.0035%、0.0036%、0.0037%、0.0038%、0.0039%、0.0040%、0.0041%、0.0042%、0.0043%、0.0044%、0.0045%、0.0046%、0.0047%、0.0048%、0.0049%、0.0050%、0.0051%、0.0052%、0.0053%、0.0054%、0.0055%、0.0056%、0.0057%、0.0058%、0.0059%、0.0060%、0.0061%、0.0062%、0.0063%、0.0064%、0.0065%、0.0066%、0.0067%、0.0068%、0.0069%、0.0070%、0.0071%、0.0072%、0.0073%、0.0074%、0.0075%、0.0076%、0.0077%、0.0078%、0.0079%、0.0080%、0.0081%、0.0082%、0.0083%、0.0084%、0.0085%、0.0086%、0.0087%、0.0088%、0.0089%、0.0090%、0.0091%、0.0092%、0.0093%、0.0094%、0.0095%、0.0096%、0.0097%、0.0098%、0.0099%、0.0100%、0.0200%、0.0250%、0.0275%、0.0300%、0.0325%、0.0350%、0.0375%、0.0400%、0.0425%、0.0450%、0.0475%、0.0500%、0.0525%、0.0550%、0.0575%、0.0600%、0.0625%、0.0650%、0.0675%、0.0700%、0.0725%、0.0750%、0.0775%、0.0800%、0.0825%、0.0850%、0.0875%、0.0900%、0.0925%、0.0950%、0.0975%、0.1000%、0.1250%、0.1500%、0.1750%、0.2000%、0.2250%、0.2500%、0.2750%、0.3000%、0.3250%、0.3500%、0.3750%、0.4000%、0.4250%、0.4500%、0.4750%、0.5000%、0.5250%、0.0550%、0.5750%、0.6000%、0.6250%、0.6500%、0.6750%、0.7000%、0.7250%、0.7500%、0.7750%、0.8000%、0.8250%、0.8500%、0.8750%、0.9000%、0.9250%、0.9500%、0.9750%、1.0%、1.1%、1.2%、1.3%、1.4%、1.5%、1.6%、1.7%、1.8%、1.9%、2.0%、2.1%、2.2%、2.3%、2.4%、2.5%、2.6%、2.7%、2.8%、2.9%、3.0%、3.1%、3.2%、3.3%、3.4%、3.5%、3.6%、3.7%、3.8%、3.9%、4.0%、4.1%、4.2%、4.3%、4.4%、4.5%、4.6%、4.7%、4.8%、4.9%、5.0%、5.1%、5.2%、5.3%、5.4%、5.5%、5.6%、5.7%、5.8%、5.9%、6.0%、6.1%、6.2%、6.3%、6.4%、6.5%、6.6%、6.7%、6.8%、6.9%、7.0%、7.1%、7.2%、7.3%、7.4%、7.5%、7.6%、7.7%、7.8%、7.9%、8.0%、8.1%、8.2%、8.3%、8.4%、8.5%、8.6%、8.7%、8.8%、8.9%、9.0%、9.1%、9.2%、9.3%、9.4%、9.5%、9.6%、9.7%、9.8%、9.9%、10%、11%、12%、13%、14%、15%、16%、17%、18%、19%、20%、21%、22%、23%、24%、25%、26%、27%、28%、29%、30%、35%、40%、45%、50%、60%、65%、70%、75%、80%、85%、90%、95%或99%或其中可得到的任何范围的至少一种在本说明书的全文和权利要求所提及的成分。在非限制性方面,该百分比可以按整个组合物的重量或体积进行计算。本领域普通技术人员会理解,给定组合物中的浓度可以根据成分的添加、替换和/或减少而变化。
本发明公开的组合物还可以包含多种抗氧化剂以阻止一种或更多种组分的氧化。另外,可以通过防腐剂,例如多种抗细菌剂和抗真菌剂,包括但不限于对羟基苯甲酸酯(例如对羟基苯甲酸甲酯、对羟基苯甲酸丙酯)、氯丁醇、苯酚、山梨酸、硫汞撒或其组合来防止微生物的作用。在一些实施方案中,组合物不含有对羟基苯甲酸酯。
B.载剂
本发明的组合物可以并入到所有类型的载剂(即,皮肤病学上可接受的载剂)中。合适载剂的非限制性实例包括乳液(例如油包水、水包油包水、水包油、水包硅酮、硅酮包水、油包水包油、硅酮包水包油的乳液)、乳霜、润肤露、溶液(水的或者水-醇的)、无水基质(例如口红和粉末)、凝胶和软膏,或通过其它方法或本领域普通技术人员会知道的前述方法的任意组合(Remington's,1990)。变化方案和其它合适的载剂对于熟练技术人员是明显的,并且适用于本发明。在某些方面,重要的是,以使得组合为化学相容并且不形成从最终产物中沉淀的络合物的方式选择化合物、成分和试剂的浓度和组合。
还预期可以单独地或组合地包封本说明书通篇指出的成分以用于递送到目标区域,例如皮肤。包封技术的非限制性实例包括使用脂质体、囊泡和/或纳米颗粒(例如生物可降解的和生物不可降解的胶体颗粒,其包含其中捕获、包封和/或吸附有所述成分的聚合材料——实例包括纳米球和纳米胶囊),所述脂质体、囊泡和/或纳米颗粒可以用作递送载剂以将该成分递送到皮肤(参见例如美国专利6,387,398;美国专利6,203,802;美国专利5,411,744;Kreuter 1998)。
C.化妆品产品和制品
本发明的组合物还可以用在许多化妆品产品中,包括但不限于防晒产品、免晒皮肤美黑产品、毛发产品、手指甲产品、保湿霜、益肤霜和蜜露、柔软剂、日用乳液、凝胶、软膏、粉底、晚霜、口红、清洁剂、爽肤水、面膜或其它已知的化妆品产品或应用。另外,化妆品产品可以配制为保留型或洗去型产品。在某些方面,本发明的组合物为独立的产品。
D.另外的成分
除了本文中申请人所公开成分的组合之外,组合物还可以包含另外的成分,例如化妆品成分和药物活性成分。这些另外的成分的非限制性实例在以下子章节中进行描述。
1.化妆品成分
CTFA国际化妆品成分词典和手册(2004和2008)描述了多种可以在本发明的情况下使用的非限制性化妆品成分。这些成分种类的实例包括:芳香剂(人工或天然的;例如葡糖酸、苯氧乙醇和三乙醇胺)、染料和着色剂(例如蓝1、蓝1色淀、红40、红28色淀、红7色淀、红6色淀、二氧化钛、单纯(Unipure)红6、单纯红28、单纯红33、单纯黄OX、单纯黄5、FD&C蓝1、D&C蓝4号、D&C绿5号、D&C橙4号、D&C红17号、D&C红6号、D&C红7号、D&C红30号、D&C红33号、D&C紫2号、D&C黄10号、D&C黄11号、铁氧化物、铬氧化物、氧化锡、群青和云母)、调味剂(例如甜叶菊(Stevia rebaudiana,甜叶)提取物)、填充剂(例如硅酸、二氧化硅、合成氟金云母和硅酸铝钙钠)、吸附剂、润滑剂、溶剂(例如水、烃、己二醇、异十二烷、辛基十二烷醇、甘油和丙二醇)、保湿剂(包括例如软化剂、湿润剂、成膜剂、密封剂和影响皮肤的天然保湿机理的试剂)、排水剂、紫外吸收剂(物理和化学吸收剂,如对氨基苯甲酸(“PABA”)和相应的PABA衍生物、二氧化钛、氧化锌等)、精油、维生素(例如维生素A、B、C、D、E和K)、微量金属(例如锌、钙和硒)、无机盐(例如氯化钠、硝酸镁和氯化镁)、抗刺激剂(例如甾族化合物和非甾族化合物抗炎剂)、植物提取物(例如芦荟(aloe vera)、甘菊、黄瓜提取物、银杏(ginkgo biloba)、人参和迷迭香)、抗微生物剂、抗氧化剂(例如BHT和生育酚)、螯合剂(例如EDTA二钠和EDTA四钠)、防腐剂(例如对羟基苯甲酸甲酯和对羟基苯甲酸丙酯)、pH调节剂(例如苹果酸、氢氧化钠、三乙醇胺和柠檬酸)、吸收剂(例如淀粉辛烯基琥珀酸铝、高岭土、玉米淀粉、燕麦淀粉、环糊精、滑石和沸石)、皮肤漂白和光亮剂(例如氢醌和烟酰胺乳酸酯)、湿润剂(例如山梨醇、尿素和甘露醇)、去角质剂、防水剂(例如镁/铝氢氧化物硬脂酸盐)、调理剂(例如芦荟提取物、尿囊素、红没药醇、神经酰胺、聚二甲基硅氧烷、透明质酸和甘草酸二钾)和成膜剂(例如丙烯酸酯类共聚物、氢化聚环戊二烯、聚乙烯、棕榈蜡、HDI/三羟甲基己内酯交联聚合物和聚季铵盐-7)。这些附加成分中一部分的非限制性实例在以下子章节中提供。
a.紫外吸收剂
可以与本发明的组合物组合使用的紫外吸收剂包括化学和物理防晒物质。可以使用的化学防晒物质的非限制性实例包括对氨基苯甲酸(PABA)、PABA酯(PABA甘油酯、戊基二甲醇PABA酯和辛基二甲醇PABA酯)、PABA丁酯、PABA乙酯、乙基二羟基丙醇PABA酯、二苯甲酮(氧苯酮、磺异苯酮、二苯甲酮和二苯甲酮-1到12)、肉桂酸盐/酯(甲氧基肉桂酸辛酯、对甲氧基肉桂酸异戊酯、辛基甲氧基肉桂酸酯、西诺沙酯、二异丙基肉桂酸甲酯、甲氧基肉桂酸DEA盐、二异丙基肉桂酸乙酯、甘油辛酸酯二甲氧基肉桂酸酯和甲氧基肉桂酸乙酯)、肉桂酸酯、水杨酸酯(均甲基水杨酸酯、水杨酸苄酯、乙二醇水杨酸酯、异丙基苄醇水杨酸酯等)、邻氨基苯甲酸盐/酯、尿刊酸乙酯、原膜散酯、水杨酸辛酯、二苯甲酰基甲烷衍生物(例如阿伏苯宗)、奥克立林、辛基三嗪酮、棓酰棓酸三油酸酯、氨基苯甲酸甘油酯、2-羟基-1,4-萘醌和二羟基丙酮、乙基己基三嗪酮、二辛基丁酰胺基三嗪酮、苯亚甲基丙二酸脂聚二甲基硅氧烷、对苯二亚甲基二莰酮磺酸、苯基二苯并咪唑四磺酸酯二钠、二乙氨基羟基苯甲酰基苯甲酸己酯、双二乙氨基羟基苯甲酰基苯甲酸酯、双苯并唑基苯基乙基己基亚氨基三嗪、甲酚曲唑三硅氧烷、亚甲基双苯并***基四甲基丁基苯酚和双乙基己基氧苯酚甲氧苯基三嗪、4-甲基苯亚甲基莰酮和4-甲氧基肉桂酸异戊酯。物理防晒物质的非限制性实例包括高岭土、滑石、凡士林和金属氧化物(例如二氧化钛和氧化锌)。
b.保湿剂
可以与本发明的组合物一起使用的保湿剂的非限制性实例包括氨基酸、硫酸软骨素、双甘油、赤藓糖醇、果糖、葡萄糖、甘油、甘油聚合物、乙二醇、1,2,6-己三醇、蜂蜜、透明质酸、氢化蜂蜜、氢化淀粉水解物、肌醇、乳糖醇、麦芽糖醇、麦芽糖、甘露醇、天然保湿因子、PEG-15丁二醇、聚甘油山梨醇、吡咯烷酮羧酸的盐、PCA钾、丙二醇、葡糖醛酸钠、PCA钠、山梨醇、蔗糖、海藻糖、尿素和木糖醇。
其它实例包括乙酰化羊毛脂、乙酰化羊毛脂醇、丙氨酸、藻类提取物、翠叶芦荟、翠叶芦荟提取物、翠叶芦荟凝胶、药蜀葵提取物、杏(prunus armeniaca)仁油、精氨酸、精氨酸天冬氨酸盐/酯、山金车提取物、天冬氨酸、鳄梨(persea gratissima)油、屏障鞘脂、丁醇、蜂蜡、山萮醇、β-谷甾醇、白桦(betula alba)树皮提取物、琉璃苣(Borago officinalis)提取物、假叶树(ruscus aculeatus)提取物、丁二醇、金盏花提取物、金盏花油、小烛树蜡、菜籽油、辛酸/癸酸甘油三酯、豆蔻(elettaria cardamomum)油、巴西棕榈蜡、胡萝卜(daucuscarota sativa)油、蓖麻油、神经酰胺、地蜡、十六/十八醇聚醚-5、十六/十八醇聚醚-12、十六/十八醇聚醚-20、鲸蜡硬脂醇辛酸酯、十六醇聚醚-20、十六醇聚醚-24、鲸蜡醇乙酸酯、鲸蜡醇辛酸酯、鲸蜡醇棕榈酸酯、洋甘菊(anthemis nobilis)油、胆固醇、胆固醇酯、胆甾醇羟基硬脂酸酯、柠檬酸、鼠尾草(salvia sclarea)油、可可(theobroma cacao)脂、椰油醇-辛酸酯/癸酸酯、椰子(cocos nucifera)油、胶原蛋白、胶原蛋白氨基酸、玉米(zea mays)油、脂肪酸、癸基油酸酯、聚二甲基硅氧烷共聚醇、聚二甲基硅氧烷醇、己二酸二辛酯、琥珀酸二辛酯、二聚季戊四醇六辛酸酯/六癸酸酯、DNA、赤藓糖醇、乙氧基二乙二醇、亚油酸乙酯、蓝桉油、月见草(oenothera biennis)油、脂肪酸、斑点老鹳草油、葡萄糖胺、葡糖谷氨酸酯、谷氨酸、甘油聚醚-26、甘油、丙三醇、二硬脂酸甘油酯、羟基硬脂酸甘油酯、月桂酸甘油酯、亚油酸甘油酯、豆蔻酸甘油酯、油酸甘油酯、硬脂酸甘油酯、硬脂酸甘油酯SE、甘氨酸、乙二醇硬脂酸酯、乙二醇硬脂酸酯SE、葡糖氨基葡聚糖、葡萄(vitis vinifera)籽油、美洲榛(corylus americana)坚果油、欧洲榛(corylus avellana)坚果油、己二醇、透明质酸、杂交红花(carthamus tinctorius)油、氢化蓖麻油、氢化椰油酸甘油酯、氢化椰子油、氢化羊毛脂、氢化卵磷脂、氢化棕榈油甘油酯、氢化棕榈仁油、氢化大豆油、氢化牛脂酸甘油酯、氢化植物油、水解胶原蛋白、水解弹性蛋白、水解葡糖氨基葡聚糖、水解角蛋白、水解大豆蛋白、羟基化羊毛脂、羟基脯氨酸、硬脂酸异鲸蜡醇酯、异鲸蜡醇硬脂酰基硬脂酸酯、油酸异癸酯、异硬脂酸异丙酯、三异硬脂酸异丙氧钛酯、羊毛脂酸异丙酯、肉豆蔻酸异丙酯、棕榈酸异丙酯、硬脂酸异丙酯、异硬脂酰胺DEA、异硬脂酸、异硬脂醇乳酸酯、异硬脂醇新戊酸酯、茉莉(jasminum officinale)油、霍霍巴油、巨藻、石栗(aleurites moluccana)坚果油、乳酰胺MEA、羊毛脂醇聚醚-16、羊毛脂醇聚醚-10乙酸酯、羊毛脂、羊毛脂酸、羊毛脂醇、羊毛脂油、羊毛脂蜡、薰衣草(lavandula angustifolia)油、卵磷脂、柠檬(citrus medica limonum)油、亚油酸、亚麻酸、澳洲坚果油、麦芽糖醇、洋甘菊(chamomilla recutita)油、甲基葡糖倍半硬脂酸酯、甲基硅烷醇PCA、矿物油、貂油、被孢霉油、肉豆蔻醇乳酸酯、肉豆蔻醇肉豆蔻酸酯、肉豆蔻醇丙酸酯、新戊二醇二辛酸酯/二癸酸酯、辛基月桂醇、辛基月桂醇肉豆蔻酸酯、辛基月桂醇硬脂酰基硬脂酸酯、羟基硬脂酸辛酯、棕榈酸辛酯、水杨酸辛酯、硬脂酸辛酯、油酸、橄榄(olea europaea)油、甜橙油、棕榈油、棕榈酸、泛硫乙胺、泛醇、泛醇基乙基醚、石蜡、PCA、桃(prunus persica)仁油、花生(arachis hypogaea)油、PEG-8C12-18酯、PEG-15椰油烷基胺、PEG-150二硬脂酸酯、PEG-60甘油异硬脂酸酯、PEG-5甘油硬脂酸酯、PEG-30甘油硬脂酸酯、PEG-7氢化蓖麻油、PEG-40氢化蓖麻油、PEG-60氢化蓖麻油、PEG-20甲基葡糖倍半硬脂酸酯、PEG40失水山梨醇全油酸酯、PEG-5大豆甾醇、PEG-10大豆甾醇、PEG-2硬脂酸酯、PEG-8硬脂酸酯、PEG-20硬脂酸酯、PEG-32硬脂酸酯、PEG-40硬脂酸酯、PEG-50硬脂酸酯、PEG-100硬脂酸酯、PEG-150硬脂酸酯、十五内酯、薄荷(mentha piperita)油、凡士林、磷脂、多氨基酸多糖缩合物、聚甘油-3二异硬脂酸酯、聚季铵盐-24、聚山梨醇酯-20、聚山梨醇酯-40、聚山梨醇酯-60、聚山梨醇酯-80、聚山梨醇酯-85、肉豆蔻酸钾、棕榈酸钾、丙二醇、丙二醇二辛酸酯/二癸酸酯、丙二醇二辛酸酯、丙二醇二壬酸酯、丙二醇月桂酸酯、丙二醇硬脂酸酯、丙二醇硬脂酸酯SE、PVP、吡哆醇二棕榈酸酯、视黄醇、视黄醇棕榈酸酯、米(oryzasativa)糠油、RNA、迷迭香(rosmarinus officinalis)油、玫瑰油、红花(carthamustinctorius)油、鼠尾草(salvia officinalis)油、檀香(santalum album)油、丝氨酸、血清蛋白、芝麻(sesamum indicum)油、牛油果(butyrospermum)脂、蚕丝粉、软骨素硫酸钠、透明质酸钠、乳酸钠、棕榈酸钠、PCA钠、聚谷氨酸钠、可溶胶原蛋白、失水山梨醇月桂酸酯、失水山梨醇油酸酯、失水山梨醇棕榈酸酯、失水山梨醇倍半油酸酯、失水山梨醇硬脂酸酯、山梨醇、大豆(glycine soja)油、鞘脂、角鲨烷、角鲨烯、硬脂酰胺MEA-硬脂酸酯、硬脂酸、硬脂氧基聚二甲基硅氧烷、硬脂氧基三甲基硅烷、硬脂醇、硬脂醇甘草亭酸酯、硬脂醇庚酸酯、硬脂醇硬脂酸酯、向日葵(helianthus annuus)籽油、甜杏仁(prunus amygdalus dulcis)油、合成蜂蜡、生育酚、乙酸生育酚酯、生育酚亚油酸酯、三山嵛精、十三烷醇新戊酸酯、十三烷醇硬脂酸酯、三乙醇胺、三硬脂酸精、尿素、植物油、水、蜡、小麦(triticum vulgare)胚芽油和依兰(cananga odorata)油。
c.抗氧化剂
可以与本公开的组合物一起使用的抗氧化剂的非限制性实例包括乙酰半胱氨酸、抗坏血酸多肽、抗坏血酸二棕榈酸酯、抗坏血酸甲基硅烷醇果胶酸酯、抗坏血酸棕榈酸酯、抗坏血酸硬脂酸酯、BHA、BHT、叔丁基氢醌、半胱氨酸、半胱氨酸HCI、二戊基氢醌、二叔丁基氢醌、二鲸蜡醇硫代二丙酸酯、二油基生育酚甲基硅烷醇、抗坏血酸硫酸酯二钠、二硬脂醇硫代二丙酸酯、双十三烷醇硫代二丙酸酯、没食子酸月桂酯、异抗坏血酸、抗坏血酸酯、阿魏酸乙酯、阿魏酸、没食子酸酯、氢醌、巯基乙酸异辛酯、曲酸、抗坏血酸镁、抗坏血酸磷酸酯镁、甲基硅烷醇抗坏血酸酯、天然植物抗氧化剂例如绿茶或葡萄籽提取物、去甲二氢愈创木酸、没食子酸辛酯、苯巯基乙酸、磷酸抗坏血酸酯生育酚酯钾、亚硫酸钾、没食子酸丙酯、醌、迷迭香酸、抗坏血酸钠、亚硫酸氢钠、异抗坏血酸钠、偏亚硫酸氢钠、亚硫酸钠、超氧化物歧化酶、巯基乙酸钠、山梨醇缩糠醛、硫二甘醇、亚硫基二乙酰胺、硫二乙酸、巯基乙酸、硫代乳酸、硫代水杨酸、生育酚聚醚-5、生育酚聚醚-10、生育酚聚醚-12、生育酚聚醚-18、生育酚聚醚-50、生育酚、托可索伦、乙酸生育酚酯、生育酚亚油酸酯、生育酚烟酸酯、生育酚琥珀酸酯和三(壬基酚)亚磷酸酯。
d.结构化剂
在其它非限制性方面,本公开的组合物可以包含结构化剂。在某些方面,结构化剂帮助给组合物提供流变学特征以有助于组合物的稳定性。在其它方面,结构化剂还可以起乳化剂或表面活性剂的作用。结构化剂的非限制性实例包括硬脂酸、棕榈酸、硬脂醇、鲸蜡醇、鲸蜡硬脂醇、PPG-30鲸蜡醚、山嵛醇、硬脂酸、棕榈酸、具有平均大约1至大约21个亚乙基氧单元的硬脂醇的聚乙二醇醚、具有平均大约1至大约5个亚乙基氧单元的鲸蜡醇的聚乙二醇醚、聚氧亚乙基甲基葡糖苷二油酸酯、月桂酸基硫酸tea盐、硬脂酸的聚乙二醇酯、C12-15烷基苯甲酸酯、二丙二醇二苯甲酸酯、PPG-15硬脂基醚苯甲酸酯、丙二醇肉豆蔻醚乙酸酯、3-羟基丙级(E)-十八碳-9-烯酸酯、失水山梨醇月桂酸酯、失水山梨醇硬脂酸酯、卡波姆、丙烯酰二甲基牛磺酸铵/2-羧基乙基丙烯酸酯交联聚合物、月桂醇聚醚硫酸酯钠、羟基丙级环糊精、PPG-26油酸酯及其混合物。
e.乳化剂
在本公开的某些方面,组合物不包含乳化剂。然而,在其它方面,组合物可以包含一种或更多种乳化剂。乳化剂可以降低相间表面张力并改善乳液的剂型和稳定性。乳化剂可以是非离子的、阳离子的、阴离子的和两性离子的乳化剂(参见McCutcheon's(1986);美国专利5,011,681号;4,421,769号;3,755,560号)。非限制性实例包括甘油酯、丙二醇酯、丙二醇的脂肪酸酯、聚丙二醇的脂肪酸酯、山梨醇的酯、失水山梨醇酐酯、羧酸共聚物、葡萄糖的酯和醚、乙氧基化的酯、乙氧基化的醇、磷酸烷基酯、聚氧乙烯脂肪醚磷酸酯、脂肪酸酰胺、酰基乳酸酯、脂肪酸盐、TEA硬脂酸酯、DEA油醇聚醚-3磷酸酯、聚乙二醇20失水山梨醇单月桂酸酯(聚山梨醇酯20)、聚乙二醇5大豆甾醇、硬脂醇聚醚-2、硬脂醇聚醚-20、硬脂醇聚醚-21、十六/十八醇聚醚-20、鲸蜡硬脂基葡糖苷、鲸蜡硬脂醇、C12-13链烷醇聚醚-3、PPG-2甲基葡糖倍半硬脂酸酯、PPG-5-鲸蜡醇聚醚-20、双-PEG/PPG-20/20聚二甲基硅氧烷、鲸蜡醇聚醚-10、聚山梨醇酯80、鲸蜡醇磷酸酯、鲸蜡醇磷酸酯钾、二乙醇胺鲸蜡醇磷酸酯、聚山梨醇酯60、甘油硬脂酸酯、PEG-100硬脂酸酯、C20-40醇类、聚羟基硬脂酸及其混合物。
f.含硅酮的化合物
在非限制性方面,含硅酮的化合物包括分子主链由交替的硅和氧原子与连接在硅原子上的侧基组成的聚合产物家族中的任何成员。通过改变-Si-O-链的长度、侧基和交联,硅酮可以合成为各种各样的材料。它们的稠度可以从液体到凝胶到固体改变。
可以在本文所描述的组合物的环境下使用的含硅酮的化合物包括在本说明书中所描述的或本领域普通技术人员已知的那些。非限制性实例包括硅油(例如挥发性和非挥发性油)、凝胶和固体。在某些方面,含硅酮的化合物包括硅油,例如聚有机硅氧烷。聚有机硅氧烷的非限制性实例包括聚二甲基硅氧烷、环聚二甲基硅氧烷、聚硅酮-11、苯基聚三甲基硅氧烷、聚三甲基硅氨基二甲基硅氧烷、硬脂氧基三甲基硅烷、或它们与其它有机硅氧烷材料以任何给定比例的混合物,以根据预期的应用(例如,至特定区域例如皮肤、毛发或眼睛)达到期望的稠度和应用特征。“挥发性硅油”包括具有低气化热的硅油,例如通常低于约50卡每克硅油。挥发性硅油的非限制性实例包括:环聚二甲基硅氧烷,例如道康宁344流体、道康宁345流体、道康宁244流体和道康宁245流体、挥发硅7207(康涅狄格州,丹伯里,联合碳化物公司);低黏度聚二甲基硅氧烷,例如黏度大约为50cst或更低的聚二甲基硅氧烷(例如,聚二甲基硅氧烷,例如道康宁200-0.5cst流体)。Dow Corning Fluid可以从密歇根州米德兰的Dow Corning Corporation购得。在CTFA化妆品成分词典的第三版中(通过引用并入),环聚二甲基硅氧烷和聚二甲基硅氧烷分别被描述为环状二甲基聚硅氧烷化合物和用三甲基硅氧基单元封端的完全甲基化的线性硅氧烷混合物。含硅酮的化合物也可以用作填充剂(例如硅酸、二氧化硅、合成的氟金云母、硼硅酸钙铝、硼硅酸钙钠和硅酸铝钙钠)。可以使用的其它非限制性挥发性硅油包括从纽约州沃特福德的General Electric Co.,Silicone Products Div.和密歇根州艾德里安的SWS Silicones Div.of StaufferChemical Co.购得的那些。
g.精油
精油包括来自药草、花朵、树木和其它植物的油。这类油一般以植物细胞间微小的液滴存在,并可以用本领域技术人员已知的若干方法进行提取(例如,蒸气蒸馏、花香提取(例如,使用脂肪提取)、浸渍、溶剂提取或机械压榨)。当这些类型的油暴露于空气时,其易于挥发(例如,挥发性油)。因此,虽然许多精油是无色的,但是随着时间其被氧化并且颜色变得更深。精油不溶于水,但溶于醇、醚、固定油(植物的)和其它有机溶剂。在精油中发现的一般物理特征包括从约160℃到240℃变化的沸点和从约0.759到约1.096的密度。
精油一般通过油被发现的来源植物命名。例如,玫瑰油或薄荷油分别来自玫瑰或薄荷植物。可以使用的精油的非限制性实例包括芝麻油、澳洲坚果油、茶树油、月见草油、西班牙鼠尾草油、西班牙迷迭香油、芫荽油、百里香油、众香果油、玫瑰油、大茴香油、凤仙花油、香柠檬油、玫瑰木油、香柏油、甘菊油、鼠尾草油、香紫苏油、丁香油、柏木油、桉油、茴香油、海茴香油、乳香油、香叶油、姜油、葡萄柚油、茉莉油、杜松子油、薰衣草油、柠檬油、柠檬草油、梨莓油、橘子油、甘牛至油、没药油、苦橙花油、橙油、绿叶油、胡椒油、黑胡椒油、苦橙叶油、松油、奥图玫瑰油、迷迭香油、檀香油、绿薄荷油、甘松油、香根草油、冬青油、依兰油。还预期本领域技术人员已知的其它精油在本文所描述的组合物中是有用的。
h.增稠剂
包括增稠剂或凝胶剂在内的增稠剂包括可以增加或控制组合物黏度的物质。增稠剂包括可以增加组合物黏度而基本上不改变组合物内活性成分功效的那些。增稠剂还可以增加本公开的组合物的稳定性。在某些方面,增稠剂包括氢化聚异丁烯或三羟基硬脂酸甘油酯、或其混合物。
可以使用的另外的增稠剂的非限制性实例包括羧酸聚合物、交联的聚丙烯酸酯聚合物、聚丙烯酰胺聚合物、多糖和胶。羧酸聚合物的实例包括含有一种或更多种衍生自丙烯酸的单体的交联化合物、取代的丙烯酸和这些丙烯酸和取代的丙烯酸的盐和酯,其中所述交联剂含有两个或更多个碳-碳双键,并衍生自多元醇(参见美国专利5,087,445号;4,509,949号;2,798,053号;CTFA国际化妆品成分词典,第四版,1991,第12和80页)。市售羧酸聚合物的实例包括卡波姆,其为丙烯酸与蔗糖或季戊四醇的烯丙基醚交联的均聚物(例如,购自B.F.Goodrich的CarbopolTM900系列)。
交联的聚丙烯酸酯聚合物的非限制性实例包括阳离子型和非离子型聚合物。实例在美国第5,100,660;4,849,484;4,835,206;4,628,078;4,599,379号中描述。
聚丙烯酰胺聚合物(包括非离子的聚丙烯酰胺聚合物,其包括取代支化的或未支化的聚合物)的非限制性实例包括聚丙烯酰胺、异构烷烃和月桂醇聚醚-7、丙烯酰胺和经取代的丙烯酰胺与丙烯酸和经取代的丙烯酸的多嵌段共聚物。
多糖的非限制性实例包括纤维素、羧甲基羟乙基纤维素、乙酸丙酸羧酸纤维素、羟乙基纤维素、羟乙基乙基纤维素、羟丙基纤维素、羟丙基甲基纤维素、甲基羟乙基纤维素、微晶纤维素、纤维素硫酸钠及其混合物。其他实例为烷基取代的纤维素,其中纤维素聚合物的羟基被羟烷基化(优选地羟乙基化或羟丙基化)以形成羟烷基化的纤维素,其然后用C10-C30直链或支链烷基基团通过醚键进行进一步改性。一般这些聚合物为C10-C30直链或支链醇与羟烷基纤维素的醚。其它有用的多糖包括硬葡聚糖类,其包含每三个单元具有一个(1-6)连接的葡萄糖的(1-3)连接的葡萄糖单元的直链。
可以使用的胶的非限制性实例包括***树胶、琼脂、藻胶、藻酸、藻酸铵、支化淀粉、藻酸钙、角叉菜胶钙、肉毒碱、角叉菜胶、糊精、明胶、结冷胶、瓜尔豆胶、瓜尔胶羟丙基三甲基氯化铵、锂蒙脱石、透明质酸、水合二氧化硅、二氧化硅、羟丙基壳聚糖、羟丙基瓜尔胶、卡拉亚胶、巨藻、角豆胶、纳豆胶、藻酸钾、角叉菜胶钾、藻酸丙二醇酯、菌核胶、羧甲基葡聚糖钠、角叉菜胶钠、黄蓍胶、黄原胶及其混合物。
增稠剂的其他非限制性实例包括卡波姆、鲸蜡醇、丙烯酰二甲基牛磺酸铵/VP共聚物、淀粉辛烯基琥珀酸铝(aluminum starch actenylsuccinate)、椰油酰胺丙基甜菜碱、PPG-2羟基乙基椰油/异硬脂酰胺、氧化锡、十六烷共聚物、硼硅酸铝钙、氧化铝、硼硅酸钠钙、硅酸铝钙钠、合成的氟金云母、地蜡、微晶蜡、司拉氯铵水辉石、碳酸亚丙酯和EDTA二钠。
i.防腐剂
可以使用的防腐剂的实例包括季铵盐防腐剂,如聚季铵盐-1和苯扎卤铵(例如苯扎氯铵(“BAC”)和苯扎溴铵)、对羟基苯甲酸酯(例如对羟基苯甲酸甲酯和对羟基苯甲酸丙酯)、苯氧乙醇、苯甲醇、氯丁醇、苯酚、山梨酸、硫汞撒、辛甘醇、碘丙炔丁基氨基甲酸酯、甲基异噻唑啉酮、甲基氯异噻唑啉酮、苯甲酸钠、二羟甲基-5,5-二甲基海因、3-碘-2-丙炔基丁基氨基甲酸酯、苯氧乙醇、辛醇、乙基己基甘油、己二醇、DMDM海因、氯苯甘醚、脱氢乙酸二钠、苯甲酸钾、苯甲酸钾或其组合。
j.调理剂
可以使用的调理剂的非限制实例包括辛乙二醇、乙基己基甘油、PEG-12聚二甲基硅氧烷、羟丙基环煳精、二甲基硅酮、生育酚醋酸酯、乳油木果脂(Butyrospermum parkii)、聚乙二醇和聚甲基聚硅氧烷的聚合物、向日葵籽油、PEG-18甘油油酸酯/椰油酸酯、环四聚二甲基硅氧烷、环己硅氧烷、环戊硅氧烷、生育酚、红花(Carthamus tinctorius)油质体、仙人果果提取物、丁二醇、尿囊素、氢化棕榈仁油、辛酸/癸酸三酸甘油酯、丙二醇硬脂酸酯、泛醇、十六烷醇的聚丙二醇醚、聚季铵盐-7、乙氧基化的甘油酯、棕榈酸乙基己酯、芦荟提取物、甜没药醇、神经酰胺、透明质酸、甘草酸二钾、烷基酰胺甜菜碱、季戊四醇四异硬脂酸酯、甘油山嵛酸酯/二十酸酯、十三烷醇偏苯三酸酯、蔗糖多大豆油酸酯、双-二甘油多酰基己二酸酯-2、硬脂酸丁酯、新戊酸异癸酯、异壬酸异壬酯及其混合物。
2.药物成分
还预期药物活性成分对本文所描述的组合物是有用的。药物活性成分的非限制性实例包括抗粉刺剂、用于处理酒渣鼻的试剂、止痛剂、麻醉剂、***直肠的、抗组胺药、包括非甾族消炎药在内的消炎剂、抗生素、抗菌剂、抗病毒素、抗微生物剂、抗癌活性物、抗疥螨剂、灭虱剂、抗肿瘤药、防汗药、止痒剂、抗牛皮癣药、抗脂溢剂、生物活性蛋白质和多肽、烧伤处理剂、烧灼剂、脱色剂、脱毛剂、尿布疹处理剂、酶、毛发生长刺激剂、包括DFMO及其盐和类似物在内的毛发生长抑制剂、止血剂、角质分离剂、口疮处理剂、唇疱疹处理剂、牙科或牙周处理剂、光敏感活性物、皮肤保护剂/屏障剂、包括激素和皮质激素的类固醇、晒伤处理剂、遮光剂、经皮活性物、鼻活性物、***活性物、疣处理剂、创伤处理剂、创伤愈合剂等。
E.试剂盒
还预期试剂盒用于本公开的某些方面。例如,本文所描述的组合物可以包括在试剂盒内。试剂盒可以包括容器。容器可以包括瓶子、金属管、层压管、塑料管、分配器、高压容器、屏障容器、包装、分室、口红容器、压缩容器、能够保存化妆品组合物的化妆品盘或其它类型的容器,例如注射或吹塑成型的塑料容器,其中保存分散体或组合物或期望的瓶子、分配器或包装。试剂盒和/或容器在其表面可包含标记。例如,标记可以是字词、短语、缩写、图片或符号。
所述容器可以分配预定量的组合物。在其他实施方案中,可以挤压容器(例如金属、层压或塑料管)以分配期望量的组合物。组合物可以以喷雾、气溶胶、液体、流体或半固体分配。容器可以具有喷雾、抽吸或挤压机构。试剂盒还可以包含使用试剂盒组分以及使用任何包含于容器内的组合物的说明书。说明书可以包含如何施用、使用和保存组合物的解释。
实施例
列出以下实施例以说明本公开的某些非限制性方面。本领域技术人员应理解,以下实施例中所公开的技术代表本发明人发现的在本发明的实践中发挥良好作用的技术。然而,本领域技术人员应理解,根据本公开,在不脱离本发明的精神和范围的条件下,所公开的具体实施方案中可以做出许多改变并仍然获得相同或相似的结果。
实施例1
口红制剂
表1至18中所列的组合物是可以在本发明的方面的情况下使用的非限制性组合物。
表1*
成分** | %浓度(以重量计) |
司拉氯铵水辉石 | 0.06 |
聚羟基硬脂酸 | 0.02 |
碳酸亚丙酯 | 0.02 |
向日葵籽油 | 6 |
季戊四醇四异硬脂酸酯 | 11 |
双-二甘油多酰基己二酸酯-2 | 10 |
异壬酸异壬酯 | 10 |
聚乙烯 | 6 |
霍霍巴脂 | 5 |
云母 | 5 |
地蜡 | 3 |
蔗糖多大豆油酸酯 | 3 |
二氧化硅 | 2 |
微晶蜡/无定形蜡 | 2 |
HDI/三羟甲基己内酯交联聚合物 | 2 |
赋形剂*** | 适量 |
*制剂可以通过在70℃至75℃加热下在烧杯中混合所述成分直到均匀来制备。然后,可以将所述制剂冷却到标准室温(20℃至25℃)。另外,如果需要的话,例如可以添加另外的成分来改变组合物的流变特性。
**可以使用本说明书中所描述的任何另外的成分(或其组合)。
***例如可以添加赋形剂以改变组合物的流变特性。
表2*
成分** | %浓度(以重量计) |
司拉氯铵水辉石 | 0.06 |
聚羟基硬脂酸 | 0.02 |
碳酸亚丙酯 | 0.02 |
向日葵籽油 | 6 |
季戊四醇四异硬脂酸酯 | 11 |
双-二甘油多酰基己二酸酯-2 | 10 |
异壬酸异壬酯 | 10 |
三异硬脂醇柠檬酸酯 | 10 |
聚乙烯 | 6 |
霍霍巴脂 | 5 |
云母 | 5 |
地蜡 | 3 |
蔗糖多大豆油酸酯 | 3 |
二氧化硅 | 2 |
微晶蜡/无定形蜡 | 2 |
HDI/三羟甲基己内酯交联聚合物 | 2 |
赋形剂*** | 适量 |
*制剂可以通过在70℃至75℃加热下在烧杯中混合所述成分直到均匀来制备。然后,可以将所述制剂冷却到标准室温(20℃至25℃)。另外,如果需要的话,例如可以添加另外的成分来改变组合物的流变特性。
**可以使用本说明书中所描述的任何另外的成分(或其组合)。
***例如可以添加赋形剂以改变组合物的流变特性。
表3*
成分** | %浓度(以重量计) |
司拉氯铵水辉石 | 0.04 |
聚羟基硬脂酸 | 0.005 |
碳酸亚丙酯 | 0.01 |
向日葵籽油 | 12 |
季戊四醇四异硬脂酸酯 | 11 |
双-二甘油多酰基己二酸酯-2 | 11 |
异壬酸异壬酯 | 10 |
聚乙烯 | 5 |
霍霍巴脂 | 6 |
云母 | 9 |
地蜡 | 2 |
蔗糖多大豆油酸酯 | 5 |
二氧化硅 | 4 |
微晶蜡/无定形蜡 | 0.5 |
HDI/三羟甲基己内酯交联聚合物 | 4 |
聚甘油-10五异硬脂酸酯 | 6 |
甘油山嵛酸酯/二十酸酯 | 0.5 |
肉荳蔻酸异丙酯 | 0.5 |
生育酚乙酸酯 | 0.5 |
赋形剂*** | 适量 |
*制剂可以通过在70℃至75℃加热下在烧杯中混合所述成分直到均匀来制备。然后,可以将所述制剂冷却到标准室温(20℃至25℃)。另外,如果需要的话,例如可以添加另外的成分来改变组合物的流变特性。
**可以使用本说明书中所描述的任何另外的成分(或其组合)。
***例如可以添加赋形剂以改变组合物的流变特性。
表4*
*制剂可以通过在70℃至75℃加热下在烧杯中混合所述成分直到均匀来制备。然后,可以将所述制剂冷却到标准室温(20℃至25℃)。另外,如果需要的话,例如可以添加附加成分来改变组合物的流变特性。
**可以使用本说明书中所描述的任何另外的成分(或其组合)。
***例如可以添加赋形剂以改变组合物的流变特性。
表5*
成分** | %浓度(以重量计) |
司拉氯铵水辉石 | 0.05 |
聚羟基硬脂酸 | 0.02 |
碳酸亚丙酯 | 0.02 |
向日葵籽油 | 6 |
季戊四醇四异硬脂酸酯 | 4 |
双-二甘油多酰基己二酸酯-2 | 11 |
异壬酸异壬酯 | 9 |
聚乙烯 | 5 |
霍霍巴脂 | 5 |
云母 | 5 |
地蜡 | 3 |
蔗糖多大豆油酸酯 | 3 |
二氧化硅 | 2 |
微晶蜡/无定形蜡 | 2 |
HDI/三羟甲基己内酯交联聚合物 | 2 |
聚甘油-2二异硬脂酸酯/IPDI共聚物 | 12 |
三异硬脂醇柠檬酸酯 | 10 |
二(PPG-3肉豆蔻基醚)己二酸酯 | 6 |
氢化聚异丁烯 | 4 |
赋形剂*** | 适量 |
*制剂可以通过在70℃至75℃加热下在烧杯中混合所述成分直到均匀来制备。然后,可以将所述制剂冷却到标准室温(20℃至25℃)。另外,如果需要的话,例如可以添加另外的成分来改变组合物的流变特性。
**可以使用本说明书中所描述的任何另外的成分(或其组合)。
***例如可以添加赋形剂以改变组合物的流变特性。
表6*
成分** | %浓度(以重量计) |
蓖麻籽油 | 24 |
油酸油醇酯 | 10 |
蜂蜡 | 5 |
小烛树蜡 | 5 |
地蜡 | 5 |
棕榈蜡 | 2 |
甲基葡糖倍半硬脂酸酯 | 2 |
赋形剂*** | 适量 |
*制剂可以通过在70℃至75℃加热下在烧杯中混合所述成分直到均匀来制备。然后,可以将所述制剂冷却到标准室温(20℃至25℃)。另外,如果需要的话,例如可以添加另外的成分以改变组合物的流变特性。
**可以使用本说明书中所描述的任何另外的成分(或其组合)。
***例如可以添加赋形剂以改变组合物的流变特性。
表7*
成分** | %浓度(以重量计) |
蓖麻籽油 | 48 |
油酸油醇酯 | 10 |
蜂蜡 | 7 |
小烛树蜡 | 6 |
地蜡 | 6 |
棕榈蜡 | 2 |
甲基葡糖倍半硬脂酸酯 | 2 |
赋形剂*** | 适量 |
*制剂可以通过在70℃至75℃加热下在烧杯中混合所述成分直到均匀来制备。然后,可以将所述制剂冷却到标准室温(20℃至25℃)。另外,如果需要的话,例如可以添加另外的成分来改变组合物的流变特性。
**可以使用本说明书中所描述的任何另外的成分(或其组合)。
***例如可以添加赋形剂以改变组合物的流变特性。
表8*
成分** | %浓度(以重量计) |
蓖麻籽油 | 50 |
油酸油醇酯 | 10 |
蜂蜡 | 5 |
小烛树蜡 | 5 |
地蜡 | 5 |
棕榈蜡 | 2 |
甲基葡糖倍半硬脂酸酯 | 2 |
着色剂 | 10.5 |
二氧化钛 | 0.5 |
赋形剂*** | 适量 |
*制剂可以通过在70℃至75℃加热下在烧杯中混合所述成分直到均匀来制备。然后,可以将所述制剂冷却到标准室温(20℃至25℃)。另外,如果需要的话,例如可以添加另外的成分来改变组合物的流变特性。
**可以使用本说明书中所描述的任何另外的成分(或其组合)。
***例如可以添加赋形剂以改变组合物的流变特性。
表9*
*制剂可以通过在70℃至75℃加热下在烧杯中混合所述成分直到均匀来制备。然后,可以将所述制剂冷却到标准室温(20至25℃)。另外,如果需要的话,例如可以添加另外的成分来改变组合物的流变特性。
**可以使用本说明书中所描述的任何另外的成分(或其组合)。
***例如可以添加赋形剂以改变组合物的流变特性。
表10*
*制剂可以通过在70℃至75℃加热下在烧杯中混合所述成分直到均匀来制备。然后,可以将所述制剂冷却到标准室温(20至25℃)。另外,如果需要的话,例如可以添加另外的成分来改变组合物的流变特性。
**可以使用本说明书中所描述的任何另外的成分(或其组合)。
***例如可以添加赋形剂以改变组合物的流变特性。
表11*
*制剂可以通过在70℃至75℃加热下在烧杯中混合所述成分直到均匀来制备。然后,可以将所述制剂冷却到标准室温(20℃至25℃)。另外,如果需要的话,例如可以添加另外的成分来改变组合物的流变特性。
**可以使用本说明书中所描述的任何另外的成分(或其组合)。
***例如可以添加赋形剂以改变组合物的流变特性。
表12*
成分** | %浓度(以重量计) |
棕榈酸乙基己酯 | 1 |
三山嵛精 | 0.2 |
失水山梨醇异硬脂酸酯 | 0.05 |
棕榈酰低聚肽 | 0.001 |
蓖麻籽油 | 33 |
霍霍巴酯 | 13 |
向日葵籽油 | 12 |
澳洲坚果油酸乙酯 | 6 |
小烛树蜡 | 6 |
芒果籽脂 | 5 |
云母 | 5 |
白池花籽油 | 4 |
蜂蜡 | 4 |
向日葵籽蜡 | 4 |
蔗糖乙酸酯异丁酸酯 | 3 |
甜橙果皮蜡 | 1 |
赋形剂*** | 适量 |
*制剂可以通过在70℃至75℃加热下在烧杯中混合所述成分直到均匀来制备。然后,可以将所述制剂冷却到标准室温(20℃至25℃)。另外,如果需要的话,例如可以添加另外的成分来改变组合物的流变特性。
**可以使用本说明书中所描述的任何另外的成分(或其组合)。
***例如可以添加赋形剂以改变组合物的流变特性。
表13*
*制剂可以通过在70℃至75℃加热下在烧杯中混合所述成分直到均匀来制备。然后,可以将所述制剂冷却到标准室温(20℃至25℃)。另外,如果需要的话,例如可以添加另外的成分来改变组合物的流变特性。
**可以使用本说明书中所描述的任何另外的成分(或其组合)。
***例如可以添加赋形剂以改变组合物的流变特性。
表14*
*制剂可以通过在70℃至75℃加热下在烧杯中混合所述成分直到均匀来制备。然后,可以将所述制剂冷却到标准室温(20℃至25℃)。另外,如果需要的话,例如可以添加另外的成分来改变组合物的流变特性。
**可以使用本说明书中所描述的任何另外的成分(或其组合)。
***例如可以添加赋形剂以改变组合物的流变特性。
表15*
*制剂可以通过在70℃至75℃加热下在烧杯中混合所述成分直到均匀来制备。然后,可以将所述制剂冷却到标准室温(20至25℃)。另外,如果需要的话,例如可以添加另外的成分来改变组合物的流变特性。
**可以使用本说明书中所描述的任何另外的成分(或其组合)。
***例如可以添加赋形剂以改变组合物的流变特性。
表16*
*制剂可以通过在70℃至75℃加热下在烧杯中混合所述成分直到均匀来制备。然后,可以将所述制剂冷却到标准室温(20℃至25℃)。另外,如果需要的话,例如可以添加另外的成分来改变组合物的流变特性。
**可以使用本说明书中所描述的任何另外的成分(或其组合)。
***例如可以添加赋形剂以改变组合物的流变特性。
表17*
成分** | %浓度(以重量计) |
聚甘油-2二异硬脂酸酯/IPDI共聚物 | 12 |
双-二甘油多酰基己二酸酯-2 | 11 |
三异硬脂醇柠檬酸酯 | 10 |
异壬酸异壬酯 | 9 |
聚乙烯 | 6 |
二(PPG-3肉豆蔻基醚)己二酸酯 | 6 |
向日葵籽油 | 6 |
霍霍巴脂 | 5 |
云母 | 5 |
氢化聚异丁烯 | 4 |
季戊四醇四异硬脂酸酯 | 4 |
地蜡 | 3 |
赋形剂*** | 适量 |
*制剂可以通过在70℃至75℃加热下在烧杯中混合所述成分直到均匀来制备。然后,可以将所述制剂冷却到标准室温(20℃至25℃)。另外,如果需要的话,例如可以添加另外的成分来改变组合物的流变特性。
**可以使用本说明书中所描述的任何另外的成分(或其组合)。
***例如可以添加赋形剂以改变组合物的流变特性。
表18*
成分** | %浓度(以重量计) |
聚甘油-2二异硬脂酸酯/IPDI共聚物 | 12 |
双-二甘油多酰基己二酸酯-2 | 11 |
三异硬脂醇柠檬酸酯 | 10 |
异壬酸异壬酯 | 10 |
聚乙烯 | 6 |
二(PPG-3肉豆蔻基醚)己二酸酯 | 6 |
向日葵籽油 | 6 |
霍霍巴脂 | 6 |
云母 | 5 |
氢化聚异丁烯 | 4 |
季戊四醇四异硬脂酸酯 | 4 |
地蜡 | 3 |
着色剂 | 4 |
赋形剂*** | 适量 |
*制剂可以通过在70℃至75℃加热下在烧杯中混合所述成分直到均匀来制备。然后,可以将所述制剂冷却到标准室温(20℃至25℃)。另外,如果需要的话,例如可以添加另外的成分来改变组合物的流变特性。
**可以使用本说明书中所描述的任何另外的成分(或其组合)。
***例如可以添加赋形剂以改变组合物的流变特性。
实施例2
分析
本说明书和权利要求全文所公开的成分的组合的功效可以通过使用以下分析来确定。
皮肤水分/水合分析:皮肤水分/水合的益处可以通过利用以Nova Dermal PhaseMeter进行的阻抗测量进行测量。阻抗计测量皮肤水分含量的变化。皮肤外层具有不同的电性质。当皮肤干燥时,其导电很差。当其变得更加含水时,产生增加的导电性。因此,皮肤阻抗(与导电性有关)的变化可以用于评价皮肤水合的变化。装置可以根据仪器说明针对每个测试日进行校准。还可以对温度和相对湿度进行标记。对受试者可以进行如下评价:测量前其可以在具有确定湿度(例如30%-50%)和温度(例如68℃-72℃)的室内进行平衡。在脸的每一侧进行三个独立的阻抗测定,并对其进行记录和平均。阻抗计可以使用T5设定,其对施用到脸上每五秒的阻抗值进行平均。变化可以以统计方差和显著性进行记录。
皮肤干燥、表面细纹、皮肤光滑度和肤色分析:皮肤干燥、表面细纹、皮肤光滑度和肤色可以用临床评分技术进行评价。例如,皮肤干燥的临床评分可以通过五点标准Kligmanscale进行确定:(0)皮肤是柔软和湿润的;(1)皮肤呈现正常而没有可见的干燥;(2)皮肤触摸感觉轻微干燥而没有可见的剥落;(3)皮肤感觉干燥、坚韧并且具有有些鳞屑的发白的外观;以及(4)皮肤感觉非常干燥、粗糙并且具有有鳞屑的发白的外观。评价可以由两个临床医师独立进行并进行平均。
肤色临床评分分析:肤色的临床评分可以通过十点模拟数值刻度实施:(10)平滑的均匀的皮肤、粉红棕色的颜色。手持放大镜检查时没有暗的、发红的或有鳞的斑块。皮肤的微观纹理摸上去非常均匀;(7)不用放大镜观察均匀的肤色。没有鳞状区域,但是有由于色素淀积或红斑引起的疹斑。没有直径大于1cm的疹斑;(4)轻易地注意到皮肤疹斑和不均匀的纹理。少量鳞片。一些区域摸上去粗糙的皮肤;以及(1)不均匀的皮肤着色和纹理。多个区域的鳞片和疹斑,色素减退型、发红的或黑色的斑点。大面积的直径超过1cm的不均匀着色。评价由两个临床医师独立进行并进行平均。
皮肤平滑度的临床评分分析:皮肤光滑度的临床评分可以通过一个十点模拟数值刻度进行分析:(10)光滑的,皮肤是湿润的和闪光的,手指划过表面时没有阻力;(7)一定程度光滑的,微小的阻力;(4)粗糙的、可见地改变的,摩擦时有摩擦力;以及(1)粗糙的、片状的、不均匀的表面。评价由两个临床医师独立进行并进行平均。
用Packman等人(1978)公开的方法进行的皮肤光滑度和皱纹减少的分析:皮肤光滑度和周围的减少也可以通过使用Packman等人(1978)公开的方法进行可视化评价。例如,每一受试者就诊时,对每一受试者的表面面线(SFL)的深度、浅度和总数量都可以进行认真的评分和记录。通过将数量因子乘以深度/宽度/长度因子得到数字的分数。获得眼睛区域和嘴巴区域(左侧和右侧)的分数,加到一起作为总的皱纹分数。
用Hargens Ballistometer进行的皮肤紧致度分析:皮肤紧致度可以用HargensBallistometer,一种通过在皮肤上落下一个小物体并记录前两个反弹峰来评价皮肤弹性和紧致度的装置,进行测量。Ballistometry是使用相对钝的探头(4平方毫米-接触面积)的小的轻量探测器。探测器轻轻地穿透进入皮肤,导致依赖于皮肤外层性质的测量,所述皮肤外层包括角质层和外表皮以及部分真皮层。
用Gas Bearing Electrodynamometer进行的皮肤柔软度/柔韧性分析:皮肤柔软度/柔韧性可以使用Gas Bearing Electrodynamometer,一种测量皮肤压力/张力性质的仪器,进行评价。皮肤的黏弹性与皮肤保湿有关。可以通过用双面胶将探测器附着在皮肤表面实现对脸颊区域特定位点的测量。大约3.5gm的力平行施加于皮肤表面,精确地测量皮肤的位移。然后可以计算皮肤的柔韧性,并表达为DSR(动态弹簧刚度,以gm/mm计)。
用复制品进行的线条和皱纹的显现分析:皮肤上线条和皱纹的显现可以使用复制品进行评价,所述复制品是皮肤表面的印模。可以使用如硅橡胶的材料。复制品可以通过图像分析进行分析。线条和皱纹可见性的变化可以通过利用硅复制品形成受试者的脸并用计算机图像分析***分析复制品图像进行客观地定量。复制品可以从眼睛区域和颈部区域获得,并用数码相机以低照明入射角进行拍摄。数字图像可以用图像处理程序进行分析并确定复制品被皱纹和细线条覆盖的区域。
用表面光度仪/记录针的方法进行的皮肤表面轮廓分析:皮肤表面轮廓可以通过使用表面光度仪/记录针的方法进行测量。这包括闪光或拖动记录针穿过复制品表面。记录针的垂直位移通过距离传感器可以录入计算机,在扫描复制品的一定距离后,皮肤轮廓的分析可以以二维曲面产生。该扫描可以沿着固定的轴重复任意次数以产生模拟的皮肤3-D图像。使用记录针技术可以获得十个随机的复制品截面,并组合产生平均值。感兴趣的值包括Ra,其为通过积分相对于平局轮廓高度的轮廓高度计算得到的所有粗糙度(高度)值的算术平均数。Rt,其为最高峰和最低谷之间的最大垂直距离,以及Rz,其为平均峰振幅减去平均峰高度。数值以用mm为单位标定的数值给出。设备应在每次使用前通过扫描已知数值的金属标准物进行标准化。Ra值可以通过下式计算:Ra=标准化粗糙度;lm=横向(扫描)长度;以及y=轮廓位置相对于平均轮廓高度的绝对值(x-轴)。
MELANODERMTM分析:在其他非限制性方面,组合物的功效可以通过使用皮肤类似物,例如举例来说MELANODERMTM,进行评估。黑素细胞,皮肤类似物中细胞的一种,当暴露于L-二羟苯基丙氨酸(L-DOPA)(黑色素的前体)时阳性着色。皮肤类似物MELANODERMTM可以用各种含有本发明的组合物和增白剂的赋形剂进行处理,或仅使用赋形剂作为对照物。或者,未处理的皮肤类似物样品可以用作对照物。
ORAC分析:芳香的皮肤活性成分和组合物的氧自由基吸收(或吸收率)能力(ORAC)还可以通过测量这类成分或组合物的抗氧化活性进行分析。该分析可以定量抑制氧化剂,例如已知导致损害细胞(例如皮肤细胞)的氧自由基,的活动的程度及所用时间。芳香的皮肤活性成分和组合物的ORAC值可以通过本领域普通技术人员已知的方法进行确定(参见U.S.公开号2004/0109905和2005/0163880;Cao等人(1993),其全部内容通过引用并入)。总之,Cao等人(1993)描述的分析测量了抗氧化化合物在测试材料中抑制氢过氧自由基生成物AAPH引起的B-藻红蛋白荧光(B-PE)下降的能力。
基质金属蛋白酶活性(MMP3;MMP9)分析:体外的基质金属蛋白酶(MMP)抑制分析。MMP是胞外蛋白酶,其凭借宽的底物特异性在许多正常的和疾病状态起作用。MMP3底物包括胶原蛋白、纤维粘连蛋白和层粘连蛋白;而MMP9底物包括胶原蛋白VII、纤维粘连蛋白和层粘连蛋白。使用来自BioMol International的用于MMP3(AK-400)和MMP-9(AK-410)的比色药物发现试剂盒,该分析设计用于测量MMP的蛋白酶活性,使用含硫多肽作为显色底物(Ac-PLG-[2-巯基-4-甲基-戊酰基]-LG-OC2H5)5,6。MMP裂解位点的肽键由含硫多肽中的硫酯键替代。该键被MMP水解产生巯基,其与DTNB[5,5'-二硫代双(2-硝基苯甲酸),埃尔曼试剂]反应生成2-硝基-5-硫代苯甲酸,可以通过其在412nm处的吸光度进行检测(在pH 6.0和高于7时,ε=13600M-1cm-1)。
胶原蛋白刺激分析:胶原蛋白是对皮肤结构关键的一种细胞外基质蛋白。增加的胶原蛋白合成帮助改善皮肤紧致度和弹性。该生物分析可以用于检测本说明书中所公开活性成分、成分的组合或具有所述组合的组合物中的任一种对人类表皮纤维母细胞的前胶原肽(胶原蛋白的前体)的产生的影响。该分析的终点是反映前胶原肽的存在和细胞活性的分光光度测量。该分析采用定量的三明治酶免疫分析技术,因此对前胶原肽特异的单克隆抗体预先涂覆在微孔板上。可以将标准品和样品移液到孔中,存在的所有前胶原肽由固定化的抗体结合。冲走所有未结合的物质后,可以将对前胶原肽特异的酶联多克隆抗体添加到孔。冲洗以去除所有未结合的抗体-酶反应物之后,可以将底物溶液添加到孔,颜色显现与最初步骤中结合的前胶原肽的量成比例,使用微孔板测定仪在450nm处检测。可以停止颜色显现,并可以测量颜色的强度。在37℃下10%的CO2中在具有10%的胎牛血清(Mediatech)的标准DMEM生长培养基中培养的亚融合的正常人类成熟表皮成纤维细胞(CascadeBiologics)用本说明书中所公开的成分的组合或具有所述组合的组合物的每一种处理3天。培养之后,可以收集细胞培养基,并可以使用来自Takara(#MK101)的三明治酶联免疫吸附分析(ELISA)定量前胶原肽分泌的量。
肿瘤坏死因子-α(TNF-α)分析:TNF超家族的原型配体,TNF-α,是一种在炎症中起主要作用的多效细胞因子。其表达的增加与促炎性活动的上调相关。该生物分析可以用来检测本说明书中所公开活性成分、成分的组合或具有所述组合的组合物中的任一种对人类表皮角化细胞的TNF-α的产生的影响。该分析的终点可以是反映TNF-α的存在和细胞活性的分光光度测量。该分析采用定量的三明治酶免疫分析技术,因此将对TNF-α特异的单克隆抗体预先涂覆在微孔板上。可以将标准品和样品可以移液到孔,存在的所有TNF-α由固定化的抗体结合。冲走所有未结合的物质后,可以将对TNF-α特异的酶联多克隆抗体添加到孔。冲洗以去除所有未结合的抗体-酶试剂之后,可以将底物溶液添加到孔,颜色显现与最初步骤中结合的TNF-α的量成比例,使用微孔板测定仪在450nm处检测。可以停止颜色显现,并可以测量颜色的强度。可以将在37℃下5%的CO2中在EpiLife标准生长培养基(CascadeBiologics)中培养的亚融合的正常人类成熟角质细胞(Cascade Biologics)用佛波醇-12-豆蔻酸酯-13-乙酸酯(PMA,10ng/ml,Sigma Chemical,#P1585-1MG)和本说明书中所公开的活性成分、成分的组合或具有所述组合的组合物的每一种处理6小时。已经表明PMA导致TNF-α分泌明显的增加,所述TNF-α分泌在处理6小时后达到峰值。培育之后,可以收集细胞培养基,并使用来自R&D Systems(#DTA00C)的三明治酶联免疫吸附分析(ELISA)定量TNF-α分泌的量。
抗氧化(AO)分析:体外生物分析测量本说明中所公开的成分、成分的组合或具有所述组合的组合物中的任一种的总抗氧化能力。该分析依赖样品中抗氧化剂抑制(2,2'-联氮-双-[3-乙基苯并噻唑啉磺酸盐])被正铁肌红蛋白氧化成/>的能力。生物体的抗氧化***包含酶,例如超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶;高分子,例如白蛋白、血浆铜蓝蛋白和铁蛋白;和大量小分子,包括抗坏血酸、α-生育酚、β-胡萝卜素、还原型谷胱甘肽、尿酸和胆红素。內源的和源自食物的抗氧化剂的总数表示细胞外液的总抗氧化能力。所有不同抗氧化剂的协作提供比单独的任何单个化合物更强的对抗反应性氧或氮自由基侵袭的保护。因此,总的抗氧化能力与测量单独组分获得的相比可以给出更相关的生物信息,因为其考虑了血浆和体液中存在的所有抗氧化剂的累积效应。样品中抗氧化剂预防ABTS氧化的能力与Trolox,一种水溶性生育酚类似物的进行比较,并以Trolox的摩尔当量进行定量。可以使用Cayman Chemical(Ann Arbor,Michigan USA)的抗氧化能力试剂盒#709001作为测量本说明中所公开的成分、成分的组合或具有所述组合的组合物中的任一种的总抗氧化能力的体外生物分析。方案可以根据制造商的建议进行。所述分析依赖样品中的抗氧化剂抑制/>(2,2'-联氮-双-[3-乙基苯并噻唑啉磺酸盐])被正铁肌红蛋白氧化成/>可以将样品中抗氧化剂防止ABTS氧化的能力与Trolox、即一种水溶性生育酚类似物的进行比较,并以Trolox的摩尔当量进行定量。
蘑菇酪氨酸酶活性分析:在哺乳动物细胞中,酪氨酸酶在来自酪氨酸(和来自多巴色素聚合)的黑色素生物合成中催化两个步骤。酪氨酸酶位于黑素细胞中,并产生给予皮肤、毛发和眼睛颜色的黑色素(芳香醌化合物)。可以将纯化的蘑菇酪氨酸酶(Sigma)在本说明书所公开的活性成分的每一个、成分的组合的任一种、或具有所述组合的组合物存在下或不存在下与其底物L-Dopa(Fisher)进行孵育。可以在490nm通过比色板读数来评估色素形成。蘑菇酪氨酸酶活性的抑制百分比可以通过与未处理的对照相比较来计算,以确定测试成分或其组合抑制纯化酶活性的能力。可以将测试成分抑制与曲酸(Sigma)的进行比较。
环氧合酶(COX)分析:体外环氧合酶-1和-2(COX-1、-2)抑制分析。COX是一种展现环氧合酶和过氧化物酶两者活性的双功能酶。环氧合酶活性将花生四烯酸转换为过氧化氢内过氧化物(***素G2;PGG2),过氧化物酶组分将内过氧化物(***素H2;PGH2)还原为相应的醇,***素、凝血噁烷和环***素的前体。该COX抑制筛选分析测量环氧合酶的过氧化物酶组分。过氧化物酶活性通过监测氧化的N,N,N',N'-四甲基-对苯二胺(TMPD)的出现进行比色分析。该抑制筛选分析包括COX-1和COX-2酶两者,以筛选同工酶特异性抑制剂。可以使用比色COX(绵羊)抑制剂筛选分析(#760111,Cayman Chemical)来分析本说明书中所公开的活性成分的每一种、成分的组合、或具有所述组合的组合物对纯化的环氧合酶(COX-1或COX-2)的影响。根据制造商的指示,可以将纯化酶、血红素和测试成分在分析缓冲液中混合,并在室温下摇动培育15分钟。培育之后,可以加入花生四烯酸和比色底物开始反应。可以在590nm下通过比色板读数来评估颜色进展。COX-1或COX-2活性的抑制百分比可以通过与未处理的对照相比较来计算,以确定测试成分抑制纯化酶活性的能力。
脂肪氧合酶(LO)分析:体外的脂肪氧合酶抑制分析。LO是非血红素的含铁的加双氧酶,其催化分子氧加成到脂肪酸。亚油酸盐/酯和花生四烯酸盐/酯是植物中和动物中LO的主要底物。然后,花生四烯酸可以转换为羟基二十三烯(HETE)酸衍生物,其随后转换为白三烯,有效的炎症介质。该分析通过测量利用花生四烯酸培养的脂肪氧合酶(5-、12-或15-LO)产生的氢过氧化物提供一种精确的和方便的用于筛选脂肪氧合酶抑制剂的方法。比色LO抑制剂筛选试剂盒(#760700,Cayman Chemical)可以用于确定本说明书中所公开的活性成分的每一种、成分的组合的任一种、或具有所述组合的组合物抑制酶活性的能力。可以将纯化的15-脂肪氧合酶和测试成分可以在分析缓冲液中混合,并在室温下摇动培育10分钟。培育之后,可以加入花生四烯酸开始反应,混合物在室温下再培育另外的10分钟。可以加入比色底物终止催化,并在490nm下通过荧光板读数来评估颜色进展。可以与未处理的对照相比较来评估脂肪氧合酶活性的抑制百分比,以确定本说明书中所公开的活性成分的每一种、成分的组合、或具有所述组合的组合物的任一种抑制纯化酶的活性的能力。。
弹性蛋白酶分析:可以使用Molecular Probes(俄勒冈州尤金,USA)的弹性蛋白酶分析(试剂盒#E-12056)作为用于测量本说明书中所公开的活性成分的每一种、成分的组合或具有所述组合的组合物的任一种的弹性蛋白酶活性抑制的体外酶抑制分析。EnzChek试剂盒含有可溶的牛颈韧带弹性蛋白,其可以用染料标记以使共轭荧光能够被淬灭。非荧光的底物可以被弹性蛋白酶或其他蛋白酶消化以产生高荧光的片段。产生的荧光增强可以用荧光微孔板测定仪进行监测。来自弹性蛋白底物的消化产物在约505nm处具有吸收最大值,在约515nm处具有荧光发射最大值。当使用EnzChek弹性蛋白酶分析试剂盒以筛选弹性蛋白酶抑制剂时,可以将肽、氯甲基酮用作选择性的、共同的弹性蛋白酶抑制剂。
油控制分析:用于测量皮脂腺中皮脂分泌的减少和/或皮脂腺中皮脂产生的减少的分析可以通过使用本领域普通技术人员已知的标准技术进行分析。在具体的例子中,可以使用前额。可以将本说明书中所公开的活性成分的每一种、成分的组合或具有所述组合的组合物的任一种每天一次或两次地施用到前额的一部分一段固定的日子(例如1、2、3、4、5、6、7、8、9、10、11、12、13、14或更多天),而前额的其他部分不用所述组合物处理。在一段固定的日子期满后,皮脂分泌可以通过将细吸墨纸施用到处理过的和未处理的前额皮肤上进行分析。这是通过首先用湿的和干的布从处理过的和未处理的区域去除所有皮脂完成的。然后吸墨纸施用到处理过的和未处理的前额区域,可以绕着前额放置橡皮筋以轻轻地将吸墨纸压到皮肤上。2小时后,吸墨纸可以移去,使其干燥,然后进行透照。越深的吸墨纸对应于越多的皮脂分泌(或较浅的吸墨纸对应于减少的皮脂分泌。
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本文中所公开和要求保护的所有组合物和/或方法可以根据本公开不需要过度的实验即制成和实现。尽管本发明的组合物和方法已经按照优选的实施方案进行了描述,但是对于本领域技术人员明显的是,可以对所述组合物和/或方法以及在本文所描述方法的步骤或步骤的顺序中实施变化,而不脱离本发明的概念、精神和范围。更具体地,明显地,化学和生理两方面都相关的特定试剂可以替代本文所描述的试剂,同时会实现相同或相似的结果。所有对本领域技术人员明显的这类相似的替代和改变都被视为在如由所附权利要求限定的本发明的精神、范围和概念内。
参考文献
以下参考文献在一定程度上提供示例性程序或对本文所陈述细节的其他补充细节,它们通过引用明确地并入本文。
Cao等人,1993年
《国际化妆品成分词典和手册》(International Cosmetic IngredientDictionary and Handbook),第12版,2008(“CTFA”),第2卷,第2399页
《国际化妆品成分词典和手册》(International Cosmetic IngredientDictionary and Handbook),第12版,2008(“CTFA”),第1卷,第198页,第655页
《国际化妆品成分词典和手册》(International Cosmetic IngredientDictionary and Handbook),第4版,1991(“CTFA”),第12和80页
Claims (14)
1.一种组合物,其包含:
带颜色的颗粒;
0.01重量%至2重量%的司拉氯铵水辉石;
0.001重量%至0.2重量%的聚羟基硬脂酸;
0.001重量%至0.3重量%的极性活化剂;
3重量%至15重量%的向日葵籽油;
1重量%至15重量%的季戊四醇四异硬脂酸酯;
7重量%至15重量%的双-二甘油多酰基己二酸酯-2;
7重量%至13重量%的异壬酸异壬酯;
3重量%至7重量%的霍霍巴脂;
3重量%至15重量%的云母;
1重量%至7重量%的地蜡;
0.1重量%至4重量%的微晶蜡/无定形蜡;
0.001重量%至1重量%的肉豆蔻酸异丙酯;和
0.01重量%至1重量%的醋酸生育酚酯;
其中所述带颜色的颗粒均匀分散在整个所述组合物中;
其中所述极性活化剂是碳酸亚丙酯;
其中所述组合物还包含增加所述组合物的可混合性的微球;并且
其中所述微球包含二氧化硅和0.5重量%至15重量%的HDI/三羟甲基己基内酯交联聚合物。
2.权利要求1所述的组合物,其中所述组合物还包含:
聚乙烯;和
蔗糖多大豆油酸酯。
3.权利要求2所述的组合物,其中所述组合物包含;
2重量%至8重量%的聚乙烯;
1重量%至6重量%的蔗糖多大豆油酸酯;和
1重量%至6重量%的二氧化硅。
4.根据权利要求1至3中任一项所述的组合物,其中所述组合物还包含甘油山嵛酸酯/二十酸酯。
5.根据权利要求1至4中任一项所述的组合物,其中所述组合物还包含:
三异硬脂酸异丙氧钛酯;和
生育酚。
6.根据权利要求1至5中任一项所述的组合物,其中所述组合物包含0.1重量%至1重量%的甘油山嵛酸酯/二十酸酯。
7.根据权利要求1至6中任一项所述的组合物,其中所述组合物包含:
0.01重量%至1重量%的三异硬脂酸异丙氧钛酯;和
0.0001重量%至1重量%的生育酚。
8.权利要求1所述的组合物,其中所述带颜色的颗粒包含着色剂;并且其中所述着色剂选自蓝1色淀、红6色淀、红7色淀、黄5色淀、铁氧化物、二氧化钛、氧化锡和云母。
9.权利要求1所述的组合物,其中所述组合物包含9重量%至13重量%的HDI/三羟甲基己基内酯交联聚合物。
10.权利要求1所述的组合物,其中所述组合物是无水的。
11.权利要求1所述的组合物,其还包含选自一种或更多种着色剂、填充剂、增稠剂、乳化剂、芳香剂、保湿剂、调理剂和抗氧化剂的一种或更多种另外的成分。
12.权利要求1所述的组合物,其中所述组合物配制成乳霜、精华、凝胶或软膏。
13.权利要求1所述的组合物,其中所述组合物是半固体。
14.一种用于使唇部着色或保湿的方法,其包括将权利要求1所述的组合物施用至唇部。
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EP3909562A3 (en) | 2022-01-26 |
EP3166574B1 (en) | 2021-03-31 |
CN117547482A (zh) | 2024-02-13 |
EP3166574A1 (en) | 2017-05-17 |
CN105250154B (zh) | 2020-08-21 |
KR102446736B1 (ko) | 2022-09-22 |
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