CN111870756A - Plasma replacement mechanism on-site monitoring system - Google Patents
Plasma replacement mechanism on-site monitoring system Download PDFInfo
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- CN111870756A CN111870756A CN202010731432.5A CN202010731432A CN111870756A CN 111870756 A CN111870756 A CN 111870756A CN 202010731432 A CN202010731432 A CN 202010731432A CN 111870756 A CN111870756 A CN 111870756A
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- pump
- patient
- monitoring device
- pressure
- plasma
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3607—Regulation parameters
- A61M1/3609—Physical characteristics of the blood, e.g. haematocrit, urea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3639—Blood pressure control, pressure transducers specially adapted therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3663—Flow rate transducers; Flow integrators
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01G—WEIGHING
- G01G19/00—Weighing apparatus or methods adapted for special purposes not provided for in the preceding groups
- G01G19/44—Weighing apparatus or methods adapted for special purposes not provided for in the preceding groups for weighing persons
- G01G19/445—Weighing apparatus or methods adapted for special purposes not provided for in the preceding groups for weighing persons in a horizontal position
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
- A61M2205/3334—Measuring or controlling the flow rate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
- A61M2205/3337—Controlling, regulating pressure or flow by means of a valve by-passing a pump
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/30—Blood pressure
Abstract
The invention relates to a plasma replacement mechanism on-site monitoring system, which comprises: the plasma replacement mechanism comprises a power assembly, a blood flow regulating device, a heparin pump, an arterial pressure monitoring device, a venous pressure monitoring device, a plasma filtrate pipeline and a pipeline pressure monitoring device, wherein the power assembly consists of a blood pump, a reverse pump, a separation pump and a liquid discharge pump; the line pressure monitoring equipment is arranged on the plasma filtrate line and used for detecting the line pressure of the plasma filtrate line. The plasma replacement mechanism field monitoring system provided by the invention is stable in operation and simple in structure. Because the plasma replacement rate can be matched with the total blood volume of the current patient on the basis of multi-parameter measurement, the same treatment effect on patients with different body types can be achieved by adopting the same set of plasma replacement mechanism.
Description
Technical Field
The invention relates to the field of liver treatment, in particular to a plasma replacement mechanism on-site monitoring system.
Background
Liver (liver), the name of human organ, one of the five zang organs. Is an organ mainly responsible for metabolic functions in the vertebrate body, and plays a role in the body, such as de-oxidation, storage of glycogen, synthesis of secreted proteins, and the like. The liver also produces bile in the digestive system. In medical practice, the liver is often described in Latin initials, hepato-or hepatic. Most liver diseases have symptoms of jaundice, which is accumulated in the body because the liver cannot continuously discharge bilirubin. The traditional Chinese medicine considers that: the liver and gallbladder are exterior and interior, open into the eyes, and the liver governs storing blood and the gallbladder governs smoothing flow of qi and blood, and has the functions of storing and regulating blood.
The human liver is mostly positioned in the right mondinal region and the upper abdomen, and the small part is positioned in the left mondinal region, the upper boundary is flat in the 5 th rib in the right clavicle midline, and the upper part is tightly attached to the diaphragm and is adjacent to the right lung and the heart; the lower part is adjacent to the stomach, duodenum and colon dextrorotation; the back of the body is in contact with the right kidney, the adrenal gland and the esophageal cardia part, is the biggest gland of the human body, is reddish brown, soft and crisp, is wedge-shaped, has a round and blunt right end and a flat and thin left end, can be divided into an upper face, a lower face, a front edge, a rear edge and a left leaf and a right leaf, generally weighs about 1200-1600 g, and accounts for 1/50 of the weight of an adult, male is slightly heavier than female, the liver of the adult is 1.4-1.8 kg for male, and 1.2-1.4 kg for female. Fetal and neonatal livers are relatively large, reaching 1/20 of body weight. The normal liver appears reddish brown in appearance, soft and brittle. The liver is in the form of an irregular wedge, the right side is blunt and thick, the left side is narrow, the left and right diameters (length) are about 25cm, the front and back diameters (width) are about 15cm, and the upper and lower diameters (thickness) are about 6 cm. The upper protrusion is rounded and contacts the diaphragm muscle, and the lower protrusion is flat and adjacent to the stomach, duodenum, gallbladder and colon. The upper liver boundary is consistent with the diaphragm muscle in position, approximately in the fifth intercostal space on the right side, and the liver has certain mobility and can move up and down along with the change of body position and breathing; the infrahepatic border is generally no longer than the costal arch, and is normally inaccessible under the costal border, sometimes under the xiphoid process, but is generally no more than 3cm, and is most accessible by children under the costal border.
Disclosure of Invention
In order to solve the technical problems in the related field, the invention provides a plasma exchange mechanism on-site monitoring system, which can match the plasma exchange rate with the total blood volume of the current patient on the basis of multi-parameter measurement, so that the same treatment effect on patients of different body types can be achieved by adopting the same set of plasma exchange mechanism.
For this reason, the present invention needs to have at least the following important points:
(1) respectively calculating the current driving power of each power component of the plasma replacement mechanism, namely a blood pump, a reverse pump, a separation pump and a drain pump based on the estimated total blood volume of the current patient so as to enable the plasma replacement speed to be matched with the total blood volume of the patient;
(2) an estimated total blood volume of the patient is calculated as a preset percentage of the current weight based on the received current weight of the patient.
According to an aspect of the present invention, there is provided an in situ plasmapheresis mechanism monitoring system, the system comprising:
the plasma replacement mechanism comprises a power assembly, a blood flow regulating device, a heparin pump, an arterial pressure monitoring device, a venous pressure monitoring device, a plasma filtrate pipeline and a pipeline pressure monitoring device, wherein the power assembly consists of a blood pump, a reverse pump, a separation pump and a liquid discharge pump;
the line pressure monitoring device is arranged on the plasma filtrate line and used for detecting the line pressure of the plasma filtrate line;
the arterial pressure monitoring device is arranged on an arterial cannula of a patient and is used for detecting the pipeline pressure of the arterial cannula of the patient;
the venous pressure monitoring device is arranged on an arterial cannula of a patient and is used for detecting the pipeline pressure of the venous cannula of the patient;
the weight measuring equipment is arranged on a sickbed where the patient is positioned and used for determining the current weight of the patient based on the load weight of the sickbed;
a data estimation mechanism connected with the weight measurement device and used for calculating the estimated total blood volume of the patient which is in a preset percentage with the current weight based on the received current weight of the patient;
the dynamic control mechanism is respectively connected with the data estimation mechanism, the blood pump, the reverse-flow pump, the separation pump and the drainage pump and is used for respectively calculating the current driving power of the blood pump, the reverse-flow pump, the separation pump and the drainage pump based on the estimated total blood volume;
wherein separately calculating respective current drive powers of the blood pump, the reverse-flow pump, the separation pump, and the drain pump based on the estimated total blood volume includes: the respective current driving powers of the blood pump, the reverse-flow pump, the separation pump and the liquid discharge pump are in direct proportion to the estimated total blood volume and are different in proportion;
wherein calculating an estimated total blood volume of the patient as a preset percentage of the current weight based on the received current weight of the patient comprises: the predetermined percentage has a value between seven percent and eight percent.
The plasma replacement mechanism field monitoring system provided by the invention is stable in operation and simple in structure. Because the plasma replacement rate can be matched with the total blood volume of the current patient on the basis of multi-parameter measurement, the same treatment effect on patients with different body types can be achieved by adopting the same set of plasma replacement mechanism.
Detailed Description
Embodiments of the in situ monitoring system for a plasmapheresis mechanism of the present invention will now be described in detail.
Artificial livers are not currently classified uniformly, and traditionally, they are classified into non-biological artificial livers, biological artificial livers and combined biological artificial livers according to the composition and properties of artificial livers. In the 50 s of the 20 th century, most researchers thought that the main cause of hepatic coma was the abnormal accumulation of toxic substances in the body, and most of these toxins were small molecule substances (less than 500 daltons) that could be analyzed, so early artificial liver devices were designed to provide the function of blood purification of small molecule toxins.
If the artificial liver is roughly classified again. The biological artificial liver is characterized in that the biological artificial liver is a biological reactor in vitro, and human-derived or animal-derived hepatocytes are used for replacing livers which cannot perform biological functions in vivo to perform a compensation function, so that the biological artificial liver is more consistent with the name of an artificial liver. However, the biological artificial liver has many problems and does not meet the clinical requirements, so the current artificial liver treatment is still physical.
The current plasma replacement mechanism of the artificial liver cannot match the rate of plasma replacement with the total blood volume of the current patient on the basis of multi-parameter measurement, so that the same treatment effect on patients with different body types cannot be achieved by adopting the same set of plasma replacement mechanism.
In order to overcome the defects, the invention builds a plasma replacement mechanism field monitoring system, and can effectively solve the corresponding technical problem.
An in-situ monitoring system for a plasma exchange mechanism according to an embodiment of the present invention includes:
the plasma replacement mechanism comprises a power assembly, a blood flow regulating device, a heparin pump, an arterial pressure monitoring device, a venous pressure monitoring device, a plasma filtrate pipeline and a pipeline pressure monitoring device, wherein the power assembly consists of a blood pump, a reverse pump, a separation pump and a liquid discharge pump;
the line pressure monitoring device is arranged on the plasma filtrate line and used for detecting the line pressure of the plasma filtrate line;
the arterial pressure monitoring device is arranged on an arterial cannula of a patient and is used for detecting the pipeline pressure of the arterial cannula of the patient;
the venous pressure monitoring device is arranged on an arterial cannula of a patient and is used for detecting the pipeline pressure of the venous cannula of the patient;
the weight measuring equipment is arranged on a sickbed where the patient is positioned and used for determining the current weight of the patient based on the load weight of the sickbed;
a data estimation mechanism connected with the weight measurement device and used for calculating the estimated total blood volume of the patient which is in a preset percentage with the current weight based on the received current weight of the patient;
the dynamic control mechanism is respectively connected with the data estimation mechanism, the blood pump, the reverse-flow pump, the separation pump and the drainage pump and is used for respectively calculating the current driving power of the blood pump, the reverse-flow pump, the separation pump and the drainage pump based on the estimated total blood volume;
wherein separately calculating respective current drive powers of the blood pump, the reverse-flow pump, the separation pump, and the drain pump based on the estimated total blood volume includes: the respective current driving powers of the blood pump, the reverse-flow pump, the separation pump and the liquid discharge pump are in direct proportion to the estimated total blood volume and are different in proportion;
wherein calculating an estimated total blood volume of the patient as a preset percentage of the current weight based on the received current weight of the patient comprises: the predetermined percentage has a value between seven percent and eight percent.
Next, a specific configuration of the in-situ plasma exchange mechanism monitoring system of the present invention will be further described.
The plasma replacement mechanism on-site monitoring system can further comprise:
and the content alarm device is respectively connected with the pipeline pressure monitoring device, the arterial pressure monitoring device and the venous pressure monitoring device.
In the plasma replacement mechanism on-site monitoring system:
the content alarm device is used for determining whether to execute corresponding pressure alarm operation or not based on the numerical value of the pipeline pressure output by the pipeline pressure monitoring device, the artery pressure monitoring device and the vein pressure monitoring device respectively.
In the plasma replacement mechanism on-site monitoring system:
the weight measurement equipment is provided with a plurality of heat dissipation holes, and the plurality of heat dissipation holes are uniformly distributed on a shell of the weight measurement equipment.
In the plasma replacement mechanism on-site monitoring system:
the dynamic control mechanism is implemented by a field programmable logic device designed based on VHDL language.
The plasma replacement mechanism on-site monitoring system can further comprise:
and the pressure sensing equipment is arranged inside the data estimation mechanism and used for sensing the internal pressure of the data estimation mechanism.
The plasma replacement mechanism on-site monitoring system can further comprise:
and the pressure alarm device is connected with the pressure sensing device and is used for executing corresponding pressure alarm operation when the received internal pressure of the data estimation mechanism exceeds the limit.
The plasma replacement mechanism on-site monitoring system can further comprise:
the parallel line socket is respectively connected with the data estimation mechanism, the dynamic control mechanism and the signal output end of the weight measuring device;
the data estimation mechanism is internally provided with a serial communication interface and is used for receiving a control signal sent by a user through the serial communication interface.
The plasma replacement mechanism on-site monitoring system can further comprise:
and the buzzer is connected with the dynamic control mechanism and used for executing the alarm action of the preset playing frequency when the dynamic control mechanism is in an abnormal state.
In addition, in the in situ monitoring system of the plasmapheresis mechanism, the data evaluation mechanism is Programmable Array Logic (PAL).
Programmable Array Logic (PAL) devices, which are introduced first by MMI corporation of America, are widely used due to the variety of output structures and flexible design. The basic structure of a PAL device feeds a programmable and array output product term to an or array, and the logic expression implemented by the PAL device has the form of a sum of products, and thus can describe any boolean transfer function. PAL devices are built internally of five basic types: (1) a basic array structure; (2) a programmable I/O structure; (3) a register output structure with feedback; (4) an exclusive or structure: (5) an arithmetic functional structure.
It should be understood that portions of the present invention may be implemented in hardware, software, firmware, or a combination thereof. In the above embodiments, the various steps or methods may be implemented in software or firmware stored in memory and executed by a suitable instruction execution system. For example, if implemented in hardware, as in another embodiment, any one or combination of the following techniques, which are known in the art, may be used: a discrete logic circuit having a logic gate circuit for implementing a logic function on a data signal, an application specific integrated circuit having an appropriate combinational logic gate circuit, a Programmable Gate Array (PGA), a Field Programmable Gate Array (FPGA), or the like.
It will be understood by those skilled in the art that all or part of the steps carried by the method for implementing the above embodiments may be implemented by hardware related to instructions of a program, which may be stored in a computer readable storage medium, and when the program is executed, the program includes one or a combination of the steps of the method embodiments.
The storage medium mentioned above may be a read-only memory, a magnetic or optical disk, etc. Although embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention, and that variations, modifications, substitutions and alterations can be made to the above embodiments by those of ordinary skill in the art within the scope of the present invention.
Claims (9)
1. A system for in situ monitoring of a plasmapheresis mechanism comprising:
the plasma replacement mechanism comprises a power assembly, a blood flow regulating device, a heparin pump, an arterial pressure monitoring device, a venous pressure monitoring device, a plasma filtrate pipeline and a pipeline pressure monitoring device, wherein the power assembly consists of a blood pump, a reverse pump, a separation pump and a liquid discharge pump;
the line pressure monitoring device is arranged on the plasma filtrate line and used for detecting the line pressure of the plasma filtrate line;
the arterial pressure monitoring device is arranged on an arterial cannula of a patient and is used for detecting the pipeline pressure of the arterial cannula of the patient;
the venous pressure monitoring device is arranged on an arterial cannula of a patient and is used for detecting the pipeline pressure of the venous cannula of the patient;
the weight measuring equipment is arranged on a sickbed where the patient is positioned and used for determining the current weight of the patient based on the load weight of the sickbed;
a data estimation mechanism connected with the weight measurement device and used for calculating the estimated total blood volume of the patient which is in a preset percentage with the current weight based on the received current weight of the patient;
the dynamic control mechanism is respectively connected with the data estimation mechanism, the blood pump, the reverse-flow pump, the separation pump and the drainage pump and is used for respectively calculating the current driving power of the blood pump, the reverse-flow pump, the separation pump and the drainage pump based on the estimated total blood volume;
wherein separately calculating respective current drive powers of the blood pump, the reverse-flow pump, the separation pump, and the drain pump based on the estimated total blood volume includes: the respective current driving powers of the blood pump, the reverse-flow pump, the separation pump and the liquid discharge pump are in direct proportion to the estimated total blood volume and are different in proportion;
wherein calculating an estimated total blood volume of the patient as a preset percentage of the current weight based on the received current weight of the patient comprises: the predetermined percentage has a value between seven percent and eight percent.
2. The plasma exchange mechanism in situ monitoring system of claim 1, further comprising:
and the content alarm device is respectively connected with the pipeline pressure monitoring device, the arterial pressure monitoring device and the venous pressure monitoring device.
3. The in situ plasmapheresis mechanism monitoring system of claim 2, wherein:
the content alarm device is used for determining whether to execute corresponding pressure alarm operation or not based on the numerical value of the pipeline pressure output by the pipeline pressure monitoring device, the artery pressure monitoring device and the vein pressure monitoring device respectively.
4. The in situ plasmapheresis mechanism monitoring system of claim 3, wherein:
the weight measurement equipment is provided with a plurality of heat dissipation holes, and the plurality of heat dissipation holes are uniformly distributed on a shell of the weight measurement equipment.
5. The in situ plasmapheresis mechanism monitoring system of claim 4, wherein:
the dynamic control mechanism is implemented by a field programmable logic device designed based on VHDL language.
6. The plasma exchange mechanism in-situ monitoring system of claim 5, further comprising:
and the pressure sensing equipment is arranged inside the data estimation mechanism and used for sensing the internal pressure of the data estimation mechanism.
7. The plasma exchange mechanism in-situ monitoring system of claim 6, further comprising:
and the pressure alarm device is connected with the pressure sensing device and is used for executing corresponding pressure alarm operation when the received internal pressure of the data estimation mechanism exceeds the limit.
8. The in situ plasmapheresis mechanism monitoring system of claim 7, further comprising:
the parallel line socket is respectively connected with the data estimation mechanism, the dynamic control mechanism and the signal output end of the weight measuring device;
the data estimation mechanism is internally provided with a serial communication interface and is used for receiving a control signal sent by a user through the serial communication interface.
9. The plasma exchange mechanism in-situ monitoring system of claim 8, further comprising:
and the buzzer is connected with the dynamic control mechanism and used for executing the alarm action of the preset playing frequency when the dynamic control mechanism is in an abnormal state.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010731432.5A CN111870756A (en) | 2020-07-27 | 2020-07-27 | Plasma replacement mechanism on-site monitoring system |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010731432.5A CN111870756A (en) | 2020-07-27 | 2020-07-27 | Plasma replacement mechanism on-site monitoring system |
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| CN111870756A true CN111870756A (en) | 2020-11-03 |
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| CN202010731432.5A Withdrawn CN111870756A (en) | 2020-07-27 | 2020-07-27 | Plasma replacement mechanism on-site monitoring system |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1786974A (en) * | 2005-12-15 | 2006-06-14 | 段钟平 | Method for predicting quantity of substituted plasma |
| CN101193667A (en) * | 2005-04-08 | 2008-06-04 | 日机装株式会社 | Hemodialysis apparatus and method for hemodialysis |
| CN102475607A (en) * | 2010-11-30 | 2012-05-30 | 上海天沐自动化仪表有限公司 | Medical weight-monitoring bed and method for monitoring weight of bedridden patients |
| US20150224241A1 (en) * | 2012-09-21 | 2015-08-13 | Gambro Lundia Ab | Apparatus and a method for extracorporeal blood treatment |
-
2020
- 2020-07-27 CN CN202010731432.5A patent/CN111870756A/en not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101193667A (en) * | 2005-04-08 | 2008-06-04 | 日机装株式会社 | Hemodialysis apparatus and method for hemodialysis |
| CN1786974A (en) * | 2005-12-15 | 2006-06-14 | 段钟平 | Method for predicting quantity of substituted plasma |
| CN102475607A (en) * | 2010-11-30 | 2012-05-30 | 上海天沐自动化仪表有限公司 | Medical weight-monitoring bed and method for monitoring weight of bedridden patients |
| US20150224241A1 (en) * | 2012-09-21 | 2015-08-13 | Gambro Lundia Ab | Apparatus and a method for extracorporeal blood treatment |
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