CN111870743A - Anti-infection and anti-coagulation coating for central venous catheter and preparation method thereof - Google Patents
Anti-infection and anti-coagulation coating for central venous catheter and preparation method thereof Download PDFInfo
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- CN111870743A CN111870743A CN202010798350.2A CN202010798350A CN111870743A CN 111870743 A CN111870743 A CN 111870743A CN 202010798350 A CN202010798350 A CN 202010798350A CN 111870743 A CN111870743 A CN 111870743A
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Abstract
The invention provides an anti-infection and anti-coagulation coating for a central venous catheter, which comprises the following raw materials, by weight, 0.1-1% of polyvinylpyrrolidone, 0.2-2% of minocycline hydrochloride, 0.7-1% of KH560 silane coupling agent, 2-3% of povidone iodine and 90-93% of medical disinfectant. A preparation method of an anti-infection and anti-coagulation coating for a central venous catheter comprises the following steps: the method comprises the following steps of (1) antibacterial sterilization elimination of the central venous catheter, povidone iodine liquid layer preparation, anti-infection anticoagulant central venous catheter preparation and finished product preparation, wherein the anti-infection anticoagulant coating is solidified on the surface of the central venous catheter at high temperature and is subjected to dip-coating processing in a multi-dip-coating mode, so that the smoothness of the central venous catheter can be improved, the friction coefficient of the central venous catheter is reduced, and the convenience in medical use and operation is ensured; the invention has simple process, easily obtained used raw materials, obvious medical effect and stronger antibacterial and anti-infection rate, can reduce medical accidents and ensure the safety of medical operation.
Description
Technical Field
The invention belongs to the technical field of medical appliances, and particularly relates to an anti-infection and anti-coagulation coating for a central venous catheter and a preparation method thereof.
Background
The international anti-infection central venous catheter is mainly applied to Arrow series products developed and produced by America Talifof company, the swelling property of a polyurethane material on the surface of the catheter is utilized to adsorb antibacterial substances widely used clinically to realize the antibacterial performance of the catheter, but no anticoagulation effect exists, the Vantex series anticoagulation anti-infection central venous catheter produced by America Edward company adopts OLIGON polymers (comprising silver, platinum and black carbon) based on polyurethane, the surface of the Vantex series anticoagulation anti-infection central venous catheter is also attached with an AMC thrombus protection layer, the product utilizes silver platinum carbon to form a microcell, silver ions with strong bactericidal performance are slowly formed under spontaneous electrochemical chemical reaction to realize the anti-infection effect, but the existing silver ion products are gradually eliminated, the America Hydromer medical coating company provides a medical coating with super-lubrication property for a platform by the self-patented technology, and can reduce the adhesion of blood cells and microorganisms on the surface of a catheter body, it does not really have the effect of anti-infection and anticoagulation.
The existing central venous catheter is widely used in clinic and is the basis of product development, related products with anti-infection performance in the market are imported, the surface modification technology of the central venous catheter is researched more in China, and a large number of research results are reported in journal patents.
However, the anti-infection and anticoagulant coating for the central venous catheter and the preparation method thereof in the prior art have the problems of poor anti-infection effect, complex process operation steps and poor antibacterial effect.
Therefore, the invention discloses an anti-infection and anti-coagulation coating for a central venous catheter and a preparation method thereof, which are very necessary.
Disclosure of Invention
In order to solve the technical problems, the invention provides an anti-infection and anticoagulation coating for a central venous catheter and a preparation method thereof, and aims to solve the problems of poor anti-infection effect, complex process operation steps and poor antibacterial effect of the anti-infection and anticoagulation coating for the central venous catheter in the prior art and the preparation method thereof. An anti-infection and anticoagulant coating for a central venous catheter comprises the following raw materials, by weight, 0.1-1% of polyvinylpyrrolidone, 0.2-2% of minocycline hydrochloride, 0.7-1% of KH560 silane coupling agent, 2-3% of povidone iodine and 90-93% of medical disinfectant.
Preferably, the povidone-iodine is a complex product of polyvinylpyrrolidone and iodine.
A preparation method of an anti-infection and anti-coagulation coating for a central venous catheter comprises the following steps:
the method comprises the following steps: the central venous catheter antibacterial sterilization eliminating process comprises the steps of taking out a central venous catheter, washing the central venous catheter by medical sterile water, drying in the air, sterilizing and sterilizing by an antibacterial sterilizing box, heating by a heating mode, removing redundant residual liquid on the surface of the central venous catheter, and storing the residual liquid in a stainless steel box at normal temperature and normal pressure for later use;
step two: the preparation of the povidone iodine liquid layer is carried out according to the following steps:
the first step is as follows: taking out the polyvinylpyrrolidone, placing the polyvinylpyrrolidone at the bottom of the beaker, stirring by a stirring rod, drying in a decompression mode to an anhydrous state, and taking out;
the second step is that: diluting the iodine solution, putting the taken polyvinylpyrrolidone into a mixing beaker, adding the iodine solution, mixing and stirring through a stirring rod, and oscillating to fully mix the polyvinylpyrrolidone and the iodine solution to generate a complex product;
the third step: heating, namely heating the complex product at high temperature, exhausting gas generated by heating through an exhaust fan, and cooling to obtain a povidone-iodine liquid layer;
step three: the preparation work of the anti-infection anticoagulant liquid layer comprises the following steps:
the first step is as follows: taking out the polyvinylpyrrolidone, placing the polyvinylpyrrolidone in a beaker, adding minocycline hydrochloride, and oscillating and stirring to prepare an anti-infection liquid layer;
the second step is that: taking out the KH560 silane coupling agent, taking out the anti-infection liquid layer, placing the anti-infection liquid layer into a beaker, adding the KH560 silane coupling agent, stirring by using a stirring rod, and mixing by oscillation to prepare an anti-infection anticoagulant liquid layer;
the third step: sterilizing and heating, oscillating the anti-infection anticoagulant liquid layer, and standing the anti-infection anticoagulant liquid layer at normal temperature and normal pressure to prepare an anti-infection anticoagulant coating;
step four: the preparation of the anti-infection anticoagulant central venous catheter comprises the following steps:
the first step is as follows: preparing a central venous catheter, taking out the antibacterial and sterilized central venous catheter, taking out the anti-infection and anticoagulation coating, dip-coating the anti-infection and anticoagulation coating on the surface of the central venous catheter by a dip-coating mode, performing dip-coating for more than two times, controlling dip-coating time within a reasonable range, and collecting the lost anti-infection and anticoagulation coating liquid;
the second step is that: standing and curing, namely placing the dip-coated anti-infection and anticoagulation central venous catheter on a stainless steel bracket, standing, simultaneously performing curing and heating operation, determining curing time within a reasonable range, and finally standing at normal temperature and normal pressure;
step five: and (5) obtaining a finished product, namely obtaining the anti-infection anticoagulant coated central venous catheter, and storing the central venous catheter in a refrigeration house at the temperature of 20-25 ℃.
Further, in the step one, the antibacterial sterilizing box adopts an ultraviolet lamp sterilizing box, and the heating mode adopts a PTC heating sheet heating mode.
Further, in the second step, the matching of the polyvinylpyrrolidone and the iodine solution in the second step is set to be 1-1.5: 1-2.
Further, in the second step, the high-temperature heating mode in the third step adopts a resistance wire heating furnace for heating, and the high-temperature is set to be 50-90 ℃.
Further, in the second step, the cooling temperature in the third step is set to 20-25 ℃.
Further, in the third step, the oscillation time in the first step is set to be 15-20 min.
Further, in the third step, the standing time in the first step is set to be 25-30 min.
Further, in step four, the dip coating interval time in the first step is set to 45 to 50 s.
Further, in the fourth step, the standing time in the second step is set to be 40-45 min.
Further, in the fourth step, the curing heating temperature in the second step is set to 120-.
Further, in step four, the curing time in the second step is set to 14 to 25 hours.
The equipment market in the scheme of the invention is sold, is not limited to typical manufacturers, and can be used for realizing the invention as long as the technical index can meet the requirement.
The unit gram in the invention can be other parts by weight, and the implementation of the scheme of the invention is not influenced.
Compared with the prior art, the invention has the following beneficial effects: the anti-infection and anti-coagulation coating for the central venous catheter and the preparation method thereof are widely applied to the technical field of medical instruments. Meanwhile, the invention has the beneficial effects that: the anti-infection anticoagulant coating is solidified on the surface of the central venous catheter at high temperature and is dip-coated in a multi-dip coating mode, so that the smoothness of the central venous catheter can be improved, the friction coefficient of the central venous catheter is reduced, and the convenience in medical use and operation is ensured; the invention has simple process, easily obtained used raw materials, obvious medical effect and stronger antibacterial and anti-infection rate, can reduce medical accidents and ensure the safety of medical operation.
Drawings
FIG. 1 is a flow chart of a method for preparing an anti-infective anticoagulant coating for a central venous catheter according to the present invention.
Fig. 2 is a flow chart of the central venous catheter antibacterial sterilization elimination process of the invention.
Fig. 3 is a flow chart of the preparation work flow of the povidone-iodine liquid layer of the present invention.
Fig. 4 is a flow chart of the preparation work flow of the anti-infective anticoagulant liquid layer of the present invention.
Detailed Description
The invention is further described below with reference to the accompanying drawings:
in the figure:
example (b):
as shown in figure 1
An anti-infection and anticoagulant coating for a central venous catheter comprises the following raw materials, by weight, 0.1-1% of polyvinylpyrrolidone, 0.2-2% of minocycline hydrochloride, 0.7-1% of KH560 silane coupling agent, 2-3% of povidone iodine and 90-93% of medical disinfectant.
Preferably, the povidone-iodine is a complex product of polyvinylpyrrolidone and iodine.
A preparation method of an anti-infection and anti-coagulation coating for a central venous catheter comprises the following steps:
s101: the central venous catheter antibacterial sterilization eliminating process comprises the steps of taking out a central venous catheter, washing the central venous catheter by medical sterile water, drying in the air, sterilizing and sterilizing by an antibacterial sterilizing box, heating by a heating mode, removing redundant residual liquid on the surface of the central venous catheter, and storing the residual liquid in a stainless steel box at normal temperature and normal pressure for later use;
s102: the preparation of the povidone iodine liquid layer is carried out according to the following steps as shown in the attached figure 2:
s201: taking out the polyvinylpyrrolidone, placing the polyvinylpyrrolidone at the bottom of the beaker, stirring by a stirring rod, drying in a decompression mode to an anhydrous state, and taking out;
s202: diluting the iodine solution, putting the taken polyvinylpyrrolidone into a mixing beaker, adding the iodine solution, mixing and stirring through a stirring rod, and oscillating to fully mix the polyvinylpyrrolidone and the iodine solution to generate a complex product;
s203: heating, namely heating the complex product at high temperature, exhausting gas generated by heating through an exhaust fan, and cooling to obtain a povidone-iodine liquid layer;
s103: the preparation work of the anti-infection anticoagulant liquid layer is as shown in the attached figure 3, and the specific operation is carried out according to the following steps:
s301: taking out the polyvinylpyrrolidone, placing the polyvinylpyrrolidone in a beaker, adding minocycline hydrochloride, and oscillating and stirring to prepare an anti-infection liquid layer;
s302: taking out the KH560 silane coupling agent, taking out the anti-infection liquid layer, placing the anti-infection liquid layer into a beaker, adding the KH560 silane coupling agent, stirring by using a stirring rod, and mixing by oscillation to prepare an anti-infection anticoagulant liquid layer;
s303: sterilizing and heating, oscillating the anti-infection anticoagulant liquid layer, and standing the anti-infection anticoagulant liquid layer at normal temperature and normal pressure to prepare an anti-infection anticoagulant coating;
s104: preparing an anti-infection anticoagulant central venous catheter, as shown in the attached figure 4, wherein the specific operation is carried out according to the following steps:
s401: preparing a central venous catheter, taking out the antibacterial and sterilized central venous catheter, taking out the anti-infection and anticoagulation coating, dip-coating the anti-infection and anticoagulation coating on the surface of the central venous catheter by a dip-coating mode, performing dip-coating for more than two times, controlling dip-coating time within a reasonable range, and collecting the lost anti-infection and anticoagulation coating liquid;
s402: standing and curing, namely placing the dip-coated anti-infection and anticoagulation central venous catheter on a stainless steel bracket, standing, simultaneously performing curing and heating operation, determining curing time within a reasonable range, and finally standing at normal temperature and normal pressure;
s105: and (5) obtaining a finished product, namely obtaining the anti-infection anticoagulant coated central venous catheter, and storing the central venous catheter in a refrigeration house at the temperature of 20-25 ℃.
Further, in S101, the antibacterial sterilization box is an ultraviolet lamp sterilization box, and the heating manner is a PTC heating plate heating manner.
Further, in S102, the polyvinylpyrrolidone and the iodine solution in S202 are set to be 1-1.5: 1-2.
Further, in S102, the high temperature heating mode in S203 is a resistance wire heating furnace, and the high temperature is set to be 50-90 ℃.
Further, in S102, the cooling temperature is set to 20 to 25 ℃.
Further, in S103, the oscillation time in S301 is set to 15-20 min.
Further, in S103, the standing time in S301 is set to be 25-30 min.
Further, in S104, the dip coating interval time in S401 is set to 45 to 50S.
Further, in S104, the standing time in S402 is set to 40-45 min.
Further, in S104, the curing heating temperature in S402 is set to 120-.
Further, in S104, the curing time in S402 is set to 14-25 h.
Specific embodiment example 1:
an anti-infection and anticoagulant coating for a central venous catheter comprises the following raw materials, by weight, 0.1% of polyvinylpyrrolidone, 0.2% of minocycline hydrochloride, 0.7% of KH560 silane coupling agent, 2% of povidone iodine and 90% of medical disinfectant.
A preparation method of an anti-infection and anti-coagulation coating for a central venous catheter comprises the following steps:
the method comprises the following steps: the central venous catheter antibacterial sterilization eliminating process comprises the steps of taking out a central venous catheter, washing the central venous catheter by medical sterile water, drying in the air, sterilizing and sterilizing by an antibacterial sterilizing box, heating by a heating mode, removing redundant residual liquid on the surface of the central venous catheter, and storing the residual liquid in a stainless steel box at normal temperature and normal pressure for later use;
step two: the preparation of the povidone iodine liquid layer is carried out according to the following steps:
the first step is as follows: taking out the polyvinylpyrrolidone, placing the polyvinylpyrrolidone at the bottom of the beaker, stirring by a stirring rod, drying in a decompression mode to an anhydrous state, and taking out;
the second step is that: diluting the iodine solution, putting the taken polyvinylpyrrolidone into a mixing beaker, adding the iodine solution, mixing and stirring through a stirring rod, and oscillating to fully mix the polyvinylpyrrolidone and the iodine solution to generate a complex product;
the third step: heating, namely heating the complex product at high temperature, exhausting gas generated by heating through an exhaust fan, and cooling to obtain a povidone-iodine liquid layer;
step three: the preparation work of the anti-infection anticoagulant liquid layer comprises the following steps:
the first step is as follows: taking out the polyvinylpyrrolidone, placing the polyvinylpyrrolidone in a beaker, adding minocycline hydrochloride, and oscillating and stirring to prepare an anti-infection liquid layer;
the second step is that: taking out the KH560 silane coupling agent, taking out the anti-infection liquid layer, placing the anti-infection liquid layer into a beaker, adding the KH560 silane coupling agent, stirring by using a stirring rod, and mixing by oscillation to prepare an anti-infection anticoagulant liquid layer;
the third step: sterilizing and heating, oscillating the anti-infection anticoagulant liquid layer, and standing the anti-infection anticoagulant liquid layer at normal temperature and normal pressure to prepare an anti-infection anticoagulant coating;
step four: the preparation of the anti-infection anticoagulant central venous catheter comprises the following steps:
the first step is as follows: preparing a central venous catheter, taking out the antibacterial and sterilized central venous catheter, taking out the anti-infection and anticoagulation coating, dip-coating the anti-infection and anticoagulation coating on the surface of the central venous catheter by a dip-coating mode, performing dip-coating for more than two times, controlling dip-coating time within a reasonable range, and collecting the lost anti-infection and anticoagulation coating liquid;
the second step is that: standing and curing, namely placing the dip-coated anti-infection and anticoagulation central venous catheter on a stainless steel bracket, standing, simultaneously performing curing and heating operation, determining curing time within a reasonable range, and finally standing at normal temperature and normal pressure;
step five: and (5) obtaining a finished product, namely obtaining the anti-infection anticoagulant coated central venous catheter, and storing the central venous catheter in a refrigeration house at the temperature of 20-25 ℃.
Specific embodiment example 2:
an anti-infection and anti-coagulation coating for a central venous catheter comprises the following raw materials, by weight, 1% of polyvinylpyrrolidone, 2% of minocycline hydrochloride, 1% of KH560 silane coupling agent, 3% of povidone iodine and 93% of medical disinfectant.
A preparation method of an anti-infection and anti-coagulation coating for a central venous catheter comprises the following steps:
the method comprises the following steps: the central venous catheter antibacterial sterilization eliminating process comprises the steps of taking out a central venous catheter, washing the central venous catheter by medical sterile water, drying in the air, sterilizing and sterilizing by an antibacterial sterilizing box, heating by a heating mode, removing redundant residual liquid on the surface of the central venous catheter, and storing the residual liquid in a stainless steel box at normal temperature and normal pressure for later use;
step two: the preparation of the povidone iodine liquid layer is carried out according to the following steps:
the first step is as follows: taking out the polyvinylpyrrolidone, placing the polyvinylpyrrolidone at the bottom of the beaker, stirring by a stirring rod, drying in a decompression mode to an anhydrous state, and taking out;
the second step is that: diluting the iodine solution, putting the taken polyvinylpyrrolidone into a mixing beaker, adding the iodine solution, mixing and stirring through a stirring rod, and oscillating to fully mix the polyvinylpyrrolidone and the iodine solution to generate a complex product;
the third step: heating, namely heating the complex product at high temperature, exhausting gas generated by heating through an exhaust fan, and cooling to obtain a povidone-iodine liquid layer;
step three: the preparation work of the anti-infection anticoagulant liquid layer comprises the following steps:
the first step is as follows: taking out the polyvinylpyrrolidone, placing the polyvinylpyrrolidone in a beaker, adding minocycline hydrochloride, and oscillating and stirring to prepare an anti-infection liquid layer;
the second step is that: taking out the KH560 silane coupling agent, taking out the anti-infection liquid layer, placing the anti-infection liquid layer into a beaker, adding the KH560 silane coupling agent, stirring by using a stirring rod, and mixing by oscillation to prepare an anti-infection anticoagulant liquid layer;
the third step: sterilizing and heating, oscillating the anti-infection anticoagulant liquid layer, and standing the anti-infection anticoagulant liquid layer at normal temperature and normal pressure to prepare an anti-infection anticoagulant coating;
step four: the preparation of the anti-infection anticoagulant central venous catheter comprises the following steps:
the first step is as follows: preparing a central venous catheter, taking out the antibacterial and sterilized central venous catheter, taking out the anti-infection and anticoagulation coating, dip-coating the anti-infection and anticoagulation coating on the surface of the central venous catheter by a dip-coating mode, performing dip-coating for more than two times, controlling dip-coating time within a reasonable range, and collecting the lost anti-infection and anticoagulation coating liquid;
the second step is that: standing and curing, namely placing the dip-coated anti-infection and anticoagulation central venous catheter on a stainless steel bracket, standing, simultaneously performing curing and heating operation, determining curing time within a reasonable range, and finally standing at normal temperature and normal pressure;
step five: and (5) obtaining a finished product, namely obtaining the anti-infection anticoagulant coated central venous catheter, and storing the central venous catheter in a refrigeration house at the temperature of 20-25 ℃.
The anti-infection anticoagulant coating is solidified on the surface of the central venous catheter at high temperature and is dip-coated in a multi-dip coating mode, so that the smoothness of the central venous catheter can be improved, the friction coefficient of the central venous catheter is reduced, and the convenience in medical use and operation is ensured; the invention has simple process, easily obtained used raw materials, obvious medical effect and stronger antibacterial and anti-infection rate, can reduce medical accidents and ensure the safety of medical operation.
The technical solutions of the present invention or similar technical solutions designed by those skilled in the art based on the teachings of the technical solutions of the present invention are all within the scope of the present invention.
Claims (10)
1. The anti-infection and anti-coagulation coating for the central venous catheter is characterized by comprising the following raw materials, by weight, 0.1-1% of polyvinylpyrrolidone, 0.2-2% of minocycline hydrochloride, 0.7-1% of KH560 silane coupling agent, 2-3% of povidone iodine and 90-93% of medical disinfectant.
2. The anti-infective anticoagulant coating of claim 1 wherein the povidone-iodine is a complex of polyvinyl pyrrolidone and iodine.
3. A preparation method of an anti-infection and anti-coagulation coating for a central venous catheter is characterized by comprising the following steps:
the method comprises the following steps: the central venous catheter antibacterial sterilization eliminating process comprises the steps of taking out a central venous catheter, washing the central venous catheter by medical sterile water, drying in the air, sterilizing and sterilizing by an antibacterial sterilizing box, heating by a heating mode, removing redundant residual liquid on the surface of the central venous catheter, and storing the residual liquid in a stainless steel box at normal temperature and normal pressure for later use;
step two: preparing a povidone iodine liquid layer;
step three: preparing an anti-infection anticoagulant liquid layer;
step four: preparing an anti-infection anticoagulant central venous catheter;
step five: and (5) obtaining a finished product, namely obtaining the anti-infection anticoagulant coated central venous catheter, and storing the central venous catheter in a refrigeration house at the temperature of 20-25 ℃.
4. The method for preparing an anti-infective and anticoagulant coating for a central venous catheter as claimed in claim 3, wherein in the second step, the povidone-iodine solution layer is prepared by the following steps:
the first step is as follows: taking out the polyvinylpyrrolidone, placing the polyvinylpyrrolidone at the bottom of the beaker, stirring by a stirring rod, drying in a decompression mode to an anhydrous state, and taking out;
the second step is that: diluting the iodine solution, putting the taken polyvinylpyrrolidone into a mixing beaker, adding the iodine solution, mixing and stirring through a stirring rod, and oscillating to fully mix the polyvinylpyrrolidone and the iodine solution to generate a complex product;
the third step: and (3) heating, namely heating the complex product at high temperature, exhausting gas generated by heating through an exhaust fan, and cooling to obtain a povidone iodine liquid layer.
5. A method for preparing an anti-infective anticoagulant coating for a central venous catheter as claimed in claim 3, wherein in step three, the anti-infective anticoagulant liquid layer is prepared by the following steps:
the first step is as follows: taking out the polyvinylpyrrolidone, placing the polyvinylpyrrolidone in a beaker, adding minocycline hydrochloride, and oscillating and stirring to prepare an anti-infection liquid layer;
the second step is that: taking out the KH560 silane coupling agent, taking out the anti-infection liquid layer, placing the anti-infection liquid layer into a beaker, adding the KH560 silane coupling agent, stirring by using a stirring rod, and mixing by oscillation to prepare an anti-infection anticoagulant liquid layer;
the third step: sterilizing and heating, oscillating the anti-infection anticoagulant liquid layer, and standing the anti-infection anticoagulant liquid layer at normal temperature and normal pressure to prepare the anti-infection anticoagulant coating.
6. The method for preparing an anti-infective anticoagulant coating for a central venous catheter as claimed in claim 3, wherein in the fourth step, the anti-infective anticoagulant central venous catheter is prepared by the following steps:
the first step is as follows: preparing a central venous catheter, taking out the antibacterial and sterilized central venous catheter, taking out the anti-infection and anticoagulation coating, dip-coating the anti-infection and anticoagulation coating on the surface of the central venous catheter by a dip-coating mode, performing dip-coating for more than two times, controlling dip-coating time within a reasonable range, and collecting the lost anti-infection and anticoagulation coating liquid;
the second step is that: and (3) standing and curing, namely placing the dip-coated anti-infection and anticoagulation central venous catheter on a stainless steel bracket, standing, performing curing and heating operation at the same time, determining the curing time within a reasonable range, and finally placing at normal temperature and normal pressure.
7. A method for preparing an anti-infective and anticoagulant coating for a central venous catheter as claimed in claim 3, wherein in step one, the antibacterial sterilizing chamber is an ultraviolet lamp sterilizing chamber, and the heating mode is a PTC heating plate heating mode.
8. The method for preparing an anti-infective, anticoagulant coating for a central venous catheter as claimed in claim 4, wherein in step two, the polyvinylpyrrolidone and iodine solution in the second step are set to 1-1.5: 1-2.
9. The method for preparing an anti-infective and anticoagulant coating for a central venous catheter as claimed in claim 4, wherein in the second step, the high-temperature heating mode in the third step is a resistance wire heating furnace, and the high-temperature is set to be 50-90 ℃.
10. The method of claim 4, wherein in step two, the cooling temperature in the third step is set to 20-25 ℃.
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| CN202011432670.2A CN112274704A (en) | 2020-08-11 | 2020-12-10 | Anti-infection and anti-coagulation coating for central venous catheter and preparation method thereof |
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| CN116212122A (en) * | 2023-05-09 | 2023-06-06 | 成都德信安创新医疗技术有限公司 | Anticoagulation coating and application and preparation method thereof |
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| CN105963796B (en) * | 2016-07-02 | 2019-06-21 | 河南驼人贝斯特医疗器械有限公司 | A kind of central venous catheter anti-infective anticoagulant coatings and preparation method thereof |
| CN110947056A (en) * | 2019-11-29 | 2020-04-03 | 河南驼人贝斯特医疗器械有限公司 | Inner and outer wall anti-infection anticoagulant remaining needle hose and preparation method thereof |
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