CN111870246A - Fixing support and temperature control integrated animal magnetic resonance visual experiment cabin device - Google Patents
Fixing support and temperature control integrated animal magnetic resonance visual experiment cabin device Download PDFInfo
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- CN111870246A CN111870246A CN202010629856.0A CN202010629856A CN111870246A CN 111870246 A CN111870246 A CN 111870246A CN 202010629856 A CN202010629856 A CN 202010629856A CN 111870246 A CN111870246 A CN 111870246A
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- 241001465754 Metazoa Species 0.000 title claims abstract description 75
- 238000002474 experimental method Methods 0.000 title claims abstract description 23
- 230000000007 visual effect Effects 0.000 title claims abstract description 16
- 210000004556 brain Anatomy 0.000 claims abstract description 20
- 238000003825 pressing Methods 0.000 claims abstract description 9
- 230000010354 integration Effects 0.000 claims description 5
- 230000008859 change Effects 0.000 claims description 4
- 206010002091 Anaesthesia Diseases 0.000 claims description 3
- 239000004696 Poly ether ether ketone Substances 0.000 claims description 3
- 229910000831 Steel Inorganic materials 0.000 claims description 3
- 230000037005 anaesthesia Effects 0.000 claims description 3
- JUPQTSLXMOCDHR-UHFFFAOYSA-N benzene-1,4-diol;bis(4-fluorophenyl)methanone Chemical compound OC1=CC=C(O)C=C1.C1=CC(F)=CC=C1C(=O)C1=CC=C(F)C=C1 JUPQTSLXMOCDHR-UHFFFAOYSA-N 0.000 claims description 3
- 239000004033 plastic Substances 0.000 claims description 3
- 229920002530 polyetherether ketone Polymers 0.000 claims description 3
- 239000010959 steel Substances 0.000 claims description 3
- 238000012800 visualization Methods 0.000 claims 6
- 230000003444 anaesthetic effect Effects 0.000 abstract description 3
- 210000003456 pulmonary alveoli Anatomy 0.000 description 5
- 238000004321 preservation Methods 0.000 description 4
- 238000002595 magnetic resonance imaging Methods 0.000 description 3
- 238000012544 monitoring process Methods 0.000 description 3
- 238000000429 assembly Methods 0.000 description 2
- 230000000712 assembly Effects 0.000 description 2
- 108010066114 cabin-2 Proteins 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000001360 synchronised effect Effects 0.000 description 2
- 208000001034 Frostbite Diseases 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000011810 insulating material Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000013307 optical fiber Substances 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000002277 temperature effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D3/00—Appliances for supporting or fettering animals for operative purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2503/00—Evaluating a particular growth phase or type of persons or animals
- A61B2503/40—Animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2503/00—Evaluating a particular growth phase or type of persons or animals
- A61B2503/42—Evaluating a particular growth phase or type of persons or animals for laboratory research
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D3/00—Appliances for supporting or fettering animals for operative purposes
- A61D2003/003—Appliances for supporting or fettering animals for operative purposes with head or neck restraining means
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Pathology (AREA)
- Biomedical Technology (AREA)
- Radiology & Medical Imaging (AREA)
- High Energy & Nuclear Physics (AREA)
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- Magnetic Resonance Imaging Apparatus (AREA)
Abstract
The invention provides a fixing brace and temperature control integrated animal magnetic resonance visual experiment cabin device, and the animal brain can be adjusted in three dimensions. It comprises an animal cabin and a brain brace; animal cabin has the push-and-pull door, animal cabin both sides one side has gas inlet and anesthetic entry, the opposite side has the gas outlet, gas inlet passes through pipe connection air compressor, air compressor passes through pipe connection through gas inlet, get into animal cabin gas duct, the animal under-deck is equipped with cabin bottom plate fixed plate, the brain brace includes the base, vertical back shaft, horizontal back shaft, the nose pressing plate, ear fixed subassembly and alveolar plate, vertical back shaft rotates to be connected at the base, horizontal back shaft rotates to be connected on vertical back shaft, alveolar plate connects on horizontal back shaft and can slide around it relatively, the nose pressing plate is connected in alveolar plate top and can reciprocate relatively it, ear fixed subassembly is connected on alveolar plate.
Description
Technical Field
The invention relates to a magnetic resonance imaging integrated fixing device, in particular to a fixing brace and temperature control integrated animal magnetic resonance visual experiment cabin device, and belongs to the technical field of medical instruments.
Background
The temperature of the magnetic resonance chamber is mostly 24 ℃, the body temperature of the anesthetized animal is reduced, the existing animal heat preservation measures basically keep normal temperature by conveying water/gas through a single pipeline, the heat preservation effect is poor, the temperature is limited to the outer side part of a body on one side, the influence of high temperature/low temperature and/or complex environment on the animal cannot be simulated, and local scald or frostbite is easily caused.
The existing animal magnetic resonance is used for fixing the anesthetized animal generally in a three-point mode, the brain of the animal cannot be adjusted in two or more dimensions, and the conscious animal cannot be fixed.
Existing magnetic resonance animal fixation assemblies do not provide for simultaneous optogenetic/fiber optic recording assemblies/windows.
The existing magnetic resonance animal fixing component does not support the visual monitoring management of the conscious animal under the magnetic resonance.
Disclosure of Invention
The invention aims to provide a fixing brace and temperature control integrated animal magnetic resonance visual experiment cabin device, which can be used for three-dimensionally adjusting the brain of an animal, fixing a sober animal, synchronously carrying out a optogenetics experiment, visually monitoring and managing the animal and simulating a complex environment according to experiment requirements.
In order to achieve the purpose, the invention is realized by the following technical scheme:
a fixed brace and temperature control integrated animal magnetic resonance visual experiment cabin device comprises an animal cabin and a brain brace;
the animal cabin is provided with a sliding door, one side of a cabin door at two sides of the animal cabin is provided with a gas inlet and an anesthetic inlet, the other side of the cabin door is provided with a gas outlet, the gas inlet is connected with an air compressor through a pipeline, the air compressor is connected through the gas inlet through a pipeline and enters a gas pipeline of the animal cabin, and a cabin bottom plate fixing plate is arranged in the animal cabin;
the brain brace sets up on cabin bottom plate fixed plate, and the brain brace includes base, vertical back shaft, horizontal back shaft, pressure nose board, the fixed subassembly of ear and alveolar plate, and vertical back shaft rotates to be connected at the base, and horizontal back shaft rotates to be connected on vertical back shaft, and alveolar plate connects on horizontal back shaft and can slide around it relatively, presses the nose board to connect in alveolar plate top and can reciprocate relatively it, and the fixed subassembly of ear is connected on the alveolar plate.
Animal fixing brace and control by temperature change integration animal magnetic resonance visual experiment cabin device preferred scheme, ear fixed subassembly include ear pole support and ear pole, and the ear pole support is T shape frame structure, and T shape frame structure open end has the through hole, threaded connection between ear pole and the through hole, and the ear pole is hollow tubular structure.
Animal fixation brace and control by temperature change integration animal magnetic resonance visual experiment cabin device preferred scheme is equipped with sliding connection subassembly between horizontal back shaft and the alveolus board, and sliding connection subassembly includes the connecting plate, and connecting plate one end is connected with horizontal back shaft, and the other end is unsettled, and the connecting plate surface is equipped with the spout, and the alveolus board is installed in the spout on the connecting plate, and the surface is equipped with the alveolus hole.
Animal fixing brace and control by temperature change integration animal magnetic resonance visual experiment cabin device preferred scheme is equipped with adjusting part between pressure nose board and the alveolus board, and adjusting part includes spliced pole, connecting axle and adjusting bolt, and spliced pole one end is fixed at the alveolus board, and the other end passes through the connecting axle and connects the pressure nose board, is equipped with adjusting bolt on the pressure nose board.
The animal fixing support and temperature control integrated animal magnetic resonance visual experiment cabin device is a preferred scheme, a rotating sleeve body is arranged on a base, one end of a longitudinal support shaft is inserted into the rotating sleeve body and provided with a positioning bolt I, the other end of the longitudinal support shaft is inserted into a connecting body, a transverse through hole is formed in the connecting body, and a transverse support shaft is inserted into the transverse through hole of the connecting body and provided with a positioning bolt II.
The animal fixing brace and the temperature control integrated animal magnetic resonance visual experiment cabin device are optimized, the brain brace is made of PEEK, and the fixing plate is made of plastic steel.
According to the preferable scheme of the animal fixing brace and temperature control integrated animal magnetic resonance visual experiment cabin device, the outer wall of an animal cabin is of an inner-layer structure and an outer-layer structure, and a vacuumizing structure is arranged between the inner layer and the outer layer.
The gas pipeline is provided with a plurality of gas holes for exhausting gas from the middle part to the tail part of the cabin; temperature sensors are respectively arranged at the air inlet and the air outlet of the animal chamber.
The invention has the advantages that: the invention uses the air compressor to convey cold/hot air into the animal cabin, and meets the experimental research requirements of normal temperature and extreme environment temperature under magnetic resonance; the brain support can be used for magnetic resonance imaging fixation of a conscious animal, and can perform up-down, left-right and front-back three-dimensional adjustment on the animal brain according to research requirements; a sliding door is designed at the top end of the temperature control cabin to wire optogenetics experimental equipment, so that the technical problem of synchronous recording of magnetic resonance and photoelectric physiology is solved; the outer wall of the animal cabin is a transparent inner layer and a transparent outer layer, so that the constant temperature effect is good, and the visual monitoring and management of animals in the cabin are realized.
Drawings
The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the principles of the invention and not to limit the invention.
Fig. 1 is a schematic structural diagram of an embodiment of the present invention.
Fig. 2 is a schematic view of the structure of the animal chamber into which gas is compressed according to an embodiment of the present invention.
Fig. 3 is a schematic structural diagram of a brain brace according to an embodiment of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the description of the present invention, it should be noted that the terms "vertical", "upper", "lower", "horizontal", and the like indicate directions
The positional or positional relationship is based on that shown in the drawings and is for convenience of description and simplicity of illustration only
Rather than indicating or implying that the device or element so referred to must have a particular orientation, be constructed and arranged in a particular orientation
Operation, and therefore, should not be construed as limiting the invention.
A fixed brace and temperature control integrated animal magnetic resonance visual experiment cabin device comprises an animal cabin and a brain brace;
the outer wall of the animal cabin 2 is of an inner-outer layer structure, a vacuumizing structure is arranged between the inner layer and the outer layer, the inner-outer layer has a certain heat preservation effect, the top of the animal cabin 2 is provided with a spare sliding door 1 for a optogenetic analyzer a, one side of a cabin door on two sides of the animal cabin is provided with a gas inlet and an anesthesia pipeline inlet 3, the other side of the cabin door is provided with an air outlet, gas in a gas storage tank b is compressed by an air compressor 5 and then is connected with the gas inlet through a valve c and a pipeline 6, the gas inlet is connected with the gas outlet through a gas;
the brain brace sets up on cabin bottom plate fixed plate 7, the brain brace includes base 8, vertical back shaft 19, horizontal back shaft 22, press nose board 4, ear fixed subassembly and alveolar plate 13, vertical back shaft 19 rotates to be connected at base 8, horizontal back shaft 22 rotates to be connected on vertical back shaft 19, alveolar plate 13 is connected on horizontal back shaft 22 and can slide around it relatively, press nose board 4 to connect in alveolar plate 13 top and can reciprocate relatively it, ear fixed subassembly connects on alveolar plate 13.
In this embodiment, the ear fixing component includes an ear rod support 14 and an ear rod 12, the ear rod support 14 is a T-shaped frame structure, the open end of the T-shaped frame structure has a through hole, the ear rod 12 is in threaded connection with the through hole, the ear rod 12 includes a cylindrical portion 122 and a frustum portion 121, and the left and right distance between the two ear rods 12 can be adjusted according to the requirement by adopting the structure.
In this embodiment, be equipped with sliding connection subassembly between horizontal back shaft 22 and alveolar plate 13, sliding connection subassembly includes connecting plate 10, and connecting plate 10 one end is connected with horizontal back shaft 22, and the other end is unsettled, and connecting plate 10 surface is equipped with the spout, and alveolar plate 13 installs the spout on the connecting plate, and the surface is equipped with the alveolar hole. By adopting the structure, the front-back distance of the thread groove plate 13 relative to the base can be adjusted.
In this embodiment, be equipped with adjusting part between nose pressing plate 4 and alveolar plate 13, adjusting part includes spliced pole 17, connecting axle 15 and adjusting bolt 16, and spliced pole one end is fixed at alveolar plate 13, and the other end passes through the connecting axle and connects nose pressing plate 4, is equipped with adjusting bolt on the nose pressing plate 4. With this structure, the distance between the nose pressing plate 4 and the alveolar plate 13 can be adjusted.
In this embodiment, a rotating sleeve body 9 is arranged on the base 8, one end of a longitudinal support shaft 19 is inserted into the rotating sleeve body 9 and is provided with a positioning bolt I20, the other end of the longitudinal support shaft 19 is inserted into the connecting body 18, a transverse through hole is arranged on the connecting body 18, and a transverse support shaft 22 is inserted into the transverse through hole of the connecting body 18 and is provided with a positioning bolt II 21. With this structure, 360 ° rotation of the longitudinal support shaft 19 and the lateral support shaft 22 can be achieved.
In this embodiment, the brain brace is made of PEEK, the fixing plate is made of plastic steel, and the pipeline 6 and the gas pipeline 4 are made of insulating materials.
In this embodiment, the gas pipe 4 is provided with a plurality of exhaust holes 401 from the middle to the cabin aft portion. Temperature sensors d and e are respectively arranged at the air inlet and the air outlet of the animal cabin, a ceramic resistance heater is adopted by a temperature control system to generate heat, and the heat output is regulated by utilizing algorithm feedback. After integration, the heat preservation performance of the inner pipeline and the outer pipeline of the magnetic resonance room is tested and evaluated, the wind speed distribution inside the cabin is simulated and tested, data is used as the optimized input of a temperature control system, and the temperature of the cabin is more stable after iteration. In addition, the cabin temperature can also be measured by an infrared thermometer through a sliding door at the top end of the cabin body. The temperature control of the animal cabin is realized by opening or closing the air feed channel and increasing or reducing the wind speed.
The working process of the invention is as follows: the adjustment of the cabin temperature control (20 ℃ to 40 ℃) is realized through the flow of air in the air storage tank → the air compressor → cold/hot air → the air input pipe → the pipeline inlet hole of the cabin body → the pipeline outlet hole, the sober/anesthetic animal enters the cabin, anesthesia or other intervention stimulation is selected according to the experimental requirement, the optical fiber coil is adjusted, and the magnetic resonance imaging is synchronized.
Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that changes may be made in the embodiments and/or equivalents thereof without departing from the spirit and scope of the invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (8)
1. The utility model provides a fixed brace and control by temperature change integration animal magnetic resonance visual experiment cabin device which characterized in that: comprises an animal cabin and a brain support;
the animal cabin (2) is provided with a sliding door (1), one side of two side cabin doors of the animal cabin (2) is provided with a gas inlet and an anesthesia pipeline inlet (3), the other side of the two side cabin doors is provided with a gas outlet, an air compressor (5) is connected through the gas inlet through a pipeline (6) and enters a gas pipeline (4) of the animal cabin (2), and a cabin bottom plate fixing plate (7) is arranged in the animal cabin (2);
the brain brace sets up on cabin bottom plate fixed plate (7) of animal cabin (2), the brain brace includes base (8), vertical back shaft (19), horizontal back shaft (22), press nose board (4), fixed subassembly of ear and alveolar plate (13), vertical back shaft (19) rotate to be connected at base (8), horizontal back shaft (22) rotate to be connected on vertical back shaft (19), alveolar plate (13) are connected on horizontal back shaft (22) and can slide around it relatively, press nose board (4) to connect in alveolar plate (13) top and can reciprocate relative to it, ear fixed subassembly is connected on alveolar plate (13).
2. A fixing brace and temperature control integrated animal magnetic resonance visualization experiment cabin device according to claim 1, which is characterized in that: the ear fixing component comprises an ear rod support (14) and an ear rod (12), the ear rod support (14) is of a T-shaped frame structure, a through hole is formed in the open end of the T-shaped frame structure, the ear rod (12) is in threaded connection with the through hole, and the ear rod (12) is of a hollow tubular structure.
3. A fixing brace and temperature control integrated animal magnetic resonance visualization experiment cabin device according to claim 1, which is characterized in that: be equipped with sliding connection subassembly between horizontal back shaft (22) and alveolar plate (13), sliding connection subassembly includes the connecting plate, and connecting plate one end is connected with horizontal back shaft (22), and the other end is unsettled, and the connecting plate surface is equipped with the spout, and alveolar plate (13) install the spout on the connecting plate, and the surface is equipped with the alveolar hole.
4. A fixing brace and temperature control integrated animal magnetic resonance visualization experiment cabin device according to claim 1, which is characterized in that: be equipped with adjusting part between nose pressing plate (4) and alveolar plate (13), adjusting part includes spliced pole (17), connecting axle (15) and adjusting bolt (16), and spliced pole one end is fixed in alveolar plate (13), and the other end passes through connecting axle connection nose pressing plate (4), is equipped with adjusting bolt on nose pressing plate (4).
5. A fixing brace and temperature control integrated animal magnetic resonance visualization experiment cabin device according to claim 1, which is characterized in that: the base (8) is provided with a rotating sleeve body (9), one end of a longitudinal support shaft (19) is inserted into the rotating sleeve body (9) and provided with a positioning bolt I (20), the other end of the longitudinal support shaft (19) is inserted into a connecting body (18), the connecting body (18) is provided with a transverse through hole, and a transverse support shaft (22) is inserted into the transverse through hole of the connecting body (18) and provided with a positioning bolt II (21).
6. The animal fixing support and temperature control integrated animal magnetic resonance visualization experiment cabin device as claimed in any one of claims 1 to 5, wherein: the brain brace is made of PEEK, and the fixing plate is made of plastic steel.
7. The animal magnetic resonance visualization experiment cabin device with integrated fixing brace and temperature control of any one of claims 1 to 5, wherein: the outer wall of the animal cabin (2) is of an inner-outer layer structure, and a vacuumizing structure is arranged between the inner layer and the outer layer.
8. The animal fixing brace and temperature controllable cabin integrated magnetic resonance experiment system as claimed in any one of claims 1 to 5, wherein: the gas pipeline is provided with a plurality of exhaust holes (401) from the middle to the tail of the cabin; temperature sensors are respectively arranged at the air inlet and the air outlet of the animal chamber.
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CN202010629856.0A CN111870246A (en) | 2020-07-03 | 2020-07-03 | Fixing support and temperature control integrated animal magnetic resonance visual experiment cabin device |
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CN202010629856.0A CN111870246A (en) | 2020-07-03 | 2020-07-03 | Fixing support and temperature control integrated animal magnetic resonance visual experiment cabin device |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112426145A (en) * | 2020-11-23 | 2021-03-02 | 中国科学院精密测量科学与技术创新研究院 | Little animal biological safety microcirculation device suitable for magnetic resonance imager |
CN115624409A (en) * | 2022-12-20 | 2023-01-20 | 江苏科标医学检测有限公司 | Intelligent scald monitoring platform and use method thereof |
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US20100269260A1 (en) * | 2009-04-27 | 2010-10-28 | Titus Lanz | Animal imaging holding device and method |
US20120278990A1 (en) * | 2011-05-06 | 2012-11-08 | Rapid Biomedical Gmbh | Assembly to perform imaging on rodents |
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CN112426145A (en) * | 2020-11-23 | 2021-03-02 | 中国科学院精密测量科学与技术创新研究院 | Little animal biological safety microcirculation device suitable for magnetic resonance imager |
CN115624409A (en) * | 2022-12-20 | 2023-01-20 | 江苏科标医学检测有限公司 | Intelligent scald monitoring platform and use method thereof |
CN115624409B (en) * | 2022-12-20 | 2023-03-10 | 江苏科标医学检测有限公司 | Intelligent scald monitoring platform and use method thereof |
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