CN111869593A - Mouse jump recording device - Google Patents
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- CN111869593A CN111869593A CN202010738909.2A CN202010738909A CN111869593A CN 111869593 A CN111869593 A CN 111869593A CN 202010738909 A CN202010738909 A CN 202010738909A CN 111869593 A CN111869593 A CN 111869593A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K29/00—Other apparatus for animal husbandry
- A01K29/005—Monitoring or measuring activity, e.g. detecting heat or mating
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- G—PHYSICS
- G01—MEASURING; TESTING
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Abstract
The invention discloses a mouse jumping recording device, which comprises a box body, a box cover, a tray, a pressure sensor and a controller, wherein the tray is arranged in the box body and is connected with a lifting device; the pressure sensor is arranged on the bottom surface of the tray and connected with the input end of the controller, the controller is also connected with the upper computer through an I/O interface, the box cover is arranged on the top of the box body, and the side wall of the box body is provided with a sliding door; the pressure sensor is arranged below the tray, so that the device can record the autonomous movement of the mouse, and can transmit data to the upper computer for storage; the tray is connected with the lifting device, and the height of the tray can be adjusted through the lifting device, so that the jumping space height of the mouse is changed; the host computer can also directly show the data of mouse autonomous movement, avoids the artifical shortcoming of carrying out analysis and count to the mouse video recording in traditional experiment, can effectually reduce experimenter's working strength, has improved efficiency and experimental data degree of accuracy.
Description
Technical Field
The invention belongs to the technical field of animal experiments, and particularly relates to a mouse jumping recording device.
Background
The mouse is the most common model animal in the current preclinical basic research, and the behavioral evaluation of the mouse can judge the functional states of the mouse, such as the motor system and the nervous system, and can be used in the research of pathogenesis and drug screening of related diseases. The motor function of the mouse is a common judgment index. Behavioral methods for mouse motor function are commonly open field detection, rotarod detection and observation of jumping, standing and suspending abilities of mice. The open field and rotarod tests are mature at present. While the jumping, standing and suspending abilities of mice are currently analyzed relatively rarely. In fact, jumping, standing and hanging of mice are very important indicators for measuring various states of the nervous system of mice. For example, in experiments to study drug addiction, mouse skipping is the most objective and commonly used screening index for assessing physical dependence of opioid analgesics. Therefore, observation and statistical recording of this index of the skip response are important for evaluating the mouse's urge to withdraw. In addition, some autistic mice also exhibit stereotypic behavior with repeated jumps, such as Shank2-/-A mouse. In the research of the neuromuscular disorder model, the index of sling is also an important index for judging the muscle strength of the mouse. Standing differs from these activities in that mice do not move their bodies while standing, but rather sense their environment, and are commonly used to assess the exploratory propensity of mice. While the exploration tendency of a mouse is usually positively correlated with its emotional state, standing is often used to study the emotional state of a mouse. For example, in behavioral studies on D2 ko (knock out) mice, stance is further divided into three categories: standing with arms, sitting and free standing (as shown in fig. 1).
Therefore, jumping, standing and suspending of the mouse are important indexes for researching the normal function of the nervous system of the mouse and judging the disease state. At present, for the recording of mouse jumping, a mouse is usually placed in a glass cylinder, a transparent observation box or a round jumping table, and experimenters carry out field observation and recording, or after recording into a video, the later stage carries out manual counting. Whether it is the field manual counting or the later manual counting, there are obvious problems: firstly, recording the condition that a person is easy to fatigue after working for a long time, and the condition of wrong counting and missing counting can occur due to the reduced attention; secondly, the moment when the mouse jumps cannot be accurately recorded by manual counting, and a certain delay exists; finally, manual counting is labor-consuming and time-consuming. In addition to pure manual counting, some people have tried to combine a vibration sensor with a data acquisition card and a computer to realize automatic recording of mouse jumping, but there are still some problems: for example, only the landing time of the mouse after jumping can be recorded, but the complete jumping process cannot be recorded, the mouse is easily interfered by vibration caused by other actions of the mouse, and the height cannot be adjusted.
Disclosure of Invention
In order to solve the problems in the prior art, the invention provides an automatic recording device for mouse jumping, which can realize automatic recording and automatic analysis of jumping, standing and hanging of a mouse, does not need manual counting analysis, can effectively reduce the working strength of experimenters, and improves the efficiency and the accuracy of experimental data. In addition, the automatic device can be expanded into a plurality of devices, so that the simultaneous detection of a plurality of mice is realized, and the detection flux and the working efficiency are improved.
In order to achieve the purpose, the invention adopts the technical scheme that: a mouse jumping recording device comprises a box body, a box cover, a tray, a pressure sensor and a controller, wherein the tray is arranged in the box body, and a lifting device is connected with the lifting tray; the pressure sensor is arranged on the bottom surface of the tray and connected with the input end of the controller, the controller is further connected with the upper computer through an I/O interface, the box cover is arranged on the top of the box body, and the side wall of the box body is provided with a sliding door.
The lifting device adopts a scissor-fork type lifting mechanism, a lead screw lifting mechanism or an electric push rod lifting mechanism; the top of the lifting device is provided with a supporting plate.
The pressure sensor adopts a beam type strain pressure sensor, an analog-to-digital converter is arranged between the pressure sensor and the controller, the pressure sensor is connected with the input end of the analog-to-digital converter, and the output end of the analog-to-digital converter is connected with the input end of the controller.
The box body is made of an acrylic plate, and the side wall of the box body is also provided with reference scale marks.
The height of the lowest point of the tray is not lower than the bottom of the sliding door.
The box cover and the box body are connected in a turnover mode.
A locking mechanism is arranged between the box cover and the box body.
The locking mechanism comprises a sliding rail and a sliding block, the sliding rail is divided into two parts which are respectively positioned on the box cover and the box body, and the sliding block is arranged on the sliding rail.
The case cover is provided with a fence structure.
The controller adopts a singlechip, the monitoring precision of the pressure sensor is not lower than 0.1g, and the measurement precision of the ADC is not lower than 0.00033 mV.
Compared with the prior art, the invention has at least the following beneficial effects:
the pressure sensor is arranged below the tray, the pressure sensor transmits the data monitored by the pressure sensor to the controller, and the data are transmitted to the upper computer by the controller, so that the automatic recording of the autonomous movement of the mouse can be realized by adopting the device, and meanwhile, the data can be transmitted to the upper computer for storage and can be analyzed after the experiment; the tray is connected with the lifting device, and the height of the tray can be adjusted through the lifting device, so that the jumping space height of the mouse can be accurately measured; the upper computer can also directly display the data of the autonomous movement of the mouse, and an experimenter can judge the movement state of the mouse according to the data, so that the defects of manual analysis and counting of mouse videos in the traditional experiment are avoided, the working intensity of the experimenter is effectively reduced, and the efficiency and the accuracy of experimental data are improved; in addition, the device is set for body data of the mouse, so that the cost is greatly reduced while the measuring range and the precision are ensured; the sliding door is arranged on the side wall of the box body, so that the mice can be conveniently placed in and discharged, the platform can be conveniently cleaned, the lifting platform can be maintained, the automatic movement of a plurality of mice can be conveniently recorded at the same time, and high-flux detection is realized.
Furthermore, the transparent acrylic plate is adopted to manufacture the box body, so that observation and camera shooting recording of the mouse state are facilitated, real-time data combination is facilitated to confirm and analyze, and the experiment efficiency is facilitated to be improved.
Furthermore, the flip type fence cover is arranged at the top of the device, so that the mouse can be prevented from jumping out, and the behavior index of the suspension times and the suspension time of the mouse in the autonomous activity can be measured.
Drawings
FIG. 1a is a schematic view of a mouse standing by supporting arms
FIG. 1b is a schematic diagram of the mouse sitting.
FIG. 1c is a schematic free standing mouse.
FIG. 2 is a schematic diagram of an embodiment of the apparatus of the present invention.
Fig. 3 is a schematic view of a box cover structure according to the present invention.
Fig. 4 is a schematic view of a slider on a case cover.
Fig. 5 is a schematic view of the case shown in fig. 2.
Fig. 6 is a schematic diagram of a sensor employed in the present invention.
Fig. 7 is a schematic structural view of the scissor lift device of the present invention.
Fig. 8 is a schematic diagram of signal transmission according to an embodiment of the present invention.
1-box body, 2-box cover, 3-tray, 4-pressure sensor, 5-lifting device, 6-slide rail and 7-slide block.
Detailed Description
The present invention will be described in detail below with reference to the accompanying drawings.
Referring to fig. 2, a mouse jumping recording apparatus includes a case 1, a case cover 2, a tray 3, a pressure sensor 4 and a controller, wherein the tray 3 is disposed in the case 1, and the liftable tray 3 is connected to a lifting device 5; pressure sensor 4 sets up in the bottom surface of tray 3, and pressure sensor 4 connection controller's input, the host computer is still connected through the IO interface to the controller, and case lid 2 sets up at the top of box 1, and the push-and-pull door is seted up to the lateral wall of box 1.
The lifting device 5 adopts a scissor-fork type lifting mechanism, a screw rod lifting mechanism or an electric push rod lifting mechanism; the top of the lifting device is provided with a supporting plate.
Referring to fig. 6, the pressure sensor 4 is a beam-type strain pressure sensor, an analog-to-digital converter is arranged between the pressure sensor and the controller, the pressure sensor 4 is connected with an input end of the analog-to-digital converter, and an output end of the analog-to-digital converter is connected with an input end of the controller.
Preferably, the box body 1 is made of a transparent acrylic plate, and the side wall of the box body 1 is further provided with reference scale marks.
The height of the lowest point of the tray 3 is not lower than the bottom of the sliding door.
The box cover 2 is connected with the box body 1 in a turnover way; a locking mechanism is arranged between the box cover 2 and the box body 1.
Referring to fig. 3 and 4, the locking mechanism includes a slide rail 6 and a slide block 7, the slide rail is divided into two parts, which are respectively located on the box cover 2 and the box body 1, the slide rail 6 is provided with the slide block 7, after the box cover 2 is covered, the two parts of slide rails 6 are butted, the slide block 7 slides and limits the two parts of slide rails, thereby locking the box cover.
Referring to fig. 7, the scissor lift mechanism includes a top plate 51 and a bottom plate 52, sliding grooves are provided on both the top plate 51 and the bottom plate 52, a hinged scissor-type connecting rod is provided between the top plate 51 and the bottom plate 52, one end of the same connecting rod is fixed to the top plate 51 or the bottom plate 52, and the other end is slidably disposed in the sliding groove of the bottom plate 52 or the top plate 51.
The jumping height of the mice of different strains and different models is different, and in order to realize accurate adjustment of the jumping height space of the mice, a lifting device is added; the height of the simple jumping container for manual counting is 30 +/-2 cm mostly, so that the highest lifting device is 26.8cm, the lowest lifting device is 11.6cm, and the adjustable range of the jumping space of the mouse in the experiment is 25cm-35cm by combining the height of the box body. As the preferred embodiment, the lifting device adopts a scissor type lifting device, and has the advantages of simple structure, convenience in maintenance and installation, simple stress and better stability. Two supporting rods of the side wings for adjustment form an X shape, one side of the X shape is fixed, the other side of the X shape slides left and right in the sliding groove to adjust the height, and the X shape can be fixed by fastening screws after being adjusted to the required height.
The box body is made of an acrylic plate, and the acrylic plate is attractive in appearance, long in service life and convenient to observe and record; wherein for the convenience put into and emit the mouse, cleaning device and to elevating gear's maintenance, installed push-pull side door additional at the back wall in the box lateral wall, neither influencing the experiment nor influencing under the prerequisite of device structure, alleviateed experimenter's work load and put into the stimulation that produces the mouse when emitting.
In order to prevent the mouse from jumping out of the box body and recording the suspension activity of the mouse during the test, the top end of the box body is provided with a flip type box cover, and an experimenter can select to cover or not cover the box body according to the experiment requirement; in order to provide an object which can be gripped by the mouse at the top end, a fence window design is added on the box cover 2, and the fence material and the sparsity degree can adopt a structure and a material which are similar to those of a cage cover above the mouse rearing cage. The box cover can adopt a buckle type flip cover design, can be operated by a single hand and has good impact resistance.
The slide rail is divided into two parts which are respectively positioned on the box cover and the box wall, the box cover is buckled at the lower part, and the slide rail is jointed into a whole. The buckle length is greater than the slide rail length, and the buckle translation is to and the mutual coincidence of case lid slide rail central line, pins the case lid.
Refer to 2 and fig. 5, the both sides wall bottom of box 1 is equipped with the bar groove, the bar groove is convenient for on the one hand to hold, and on the other hand, under the condition of not picking up box 1, can also follow bar groove department manual regulation and cut fork elevating system, adjust the layer board height.
As an alternative embodiment, the lid is connected to the side walls of the box by means of hinge hinges which allow the lid to reach two operating positions, namely fully open and fully closed.
Referring to fig. 8, in order to analyze the autonomic activity of the mouse, the present apparatus selects the pressure generated during the activity of the mouse to be detected and the mechanical characteristics through the different states of the mouse as data for plotting the pressure-time relationship. Therefore, the device adopts the pressure sensor to collect pressure signals when the mouse moves and convert the pressure signals into electric signals, then analog signals are converted into digital signals through the analog-to-digital converter, the digital signals are transmitted to the single chip microcomputer and then are stored through the single chip microcomputer and the memory, or the single chip microcomputer is in direct communication with the upper computer, the signals are transmitted to the upper computer and are processed by the upper computer, and human-computer interaction and image result data output are achieved.
The device integrates the consideration of multiple aspects such as price, precision and difficulty in manufacturing, and adopts a beam type tension and pressure sensor.
The weight of a mouse is light, and elastic sensitive elements commonly used by the beam type tension and pressure sensor are column type, ring type, beam type and S type, wherein the beam type structure is simple, the larger sensitivity can be obtained, and the temperature compensation and the interference elimination of the non-measurement direction stress can be realized, so the beam type tension and pressure sensor is preferably adopted in the invention.
The working voltage of the pressure sensor adopted by the invention is 5-12V, and the pressure sensor can be directly powered by a Micro Control Unit (MCU), namely, the singlechip directly supplies power without an external power supply. The rated range L is 3KG, and the measurement accuracy is B level (0.03%. the rated range 3KG equals 0.1g), completely satisfies the demand of recording mouse autonomic motion, and the relational formula between sensor output voltage U1 and pressure F and reference voltage U0 is as follows:
U1＝U0*RO*F/g/L
wherein, RO is the limit output 2mV/V, g is the gravity acceleration 9.8m/s2And L is the rated range of 3KG, and the estimated value range of U1 is 0-10 mV.
ADC operating voltage range: the analog power supply output of the singlechip is taken as the power supply of the AD, the conventional analog voltage source output of the singlechip is 5V, the working voltage range of the ADC comprises 5V, the digit: according to the pressure sensor design derivation, the value range of the sensor output voltage U1 is only 0-10mV, the rated range is 3KG, the precision is 0.1g, the ADC measurement precision is not lower than 10 mV/30000-0.00033 mV, the measurement is not distorted, the AD digit is X, the measurement precision is Y, and the ADC has an equation under the condition that the reference voltage is 5V
Y is 5000 mV/2^ X <0.00033mV, X is a positive integer
The minimum value of X is 24, and when the value of X is 24, the measurement precision is 0.000298 mV.
In view of the above requirements, HX711 is preferred as the ADC of the present device.
A controller: the Arduino has the characteristics of cross-platform performance and easiness in learning and mastering, and the Arduino UNO is used as a single chip microcomputer module of the device.
As an optional embodiment, the side wall of the box body 1 is further provided with an infrared sensor, the infrared sensor is connected with the input end of the controller, the infrared sensor is connected with the side wall of the box body 1 in a sliding manner, and the infrared sensor can move up and down along the box body 1; the controller is also connected with a storage through an I/O interface, can adopt the infrared sensor to assist in acquiring height data of the mouse in each link, and can store the height data for a researcher to analyze together with data acquired by the pressure sensor in a later stage.
Based on the device according to the present invention,
1. covering the box cover, and sliding the buckle to the position of the baffle plate rightwards;
2. connecting a controller with an upper computer (PC) by using a data line, opening Arduino software installed on the PC, and selecting a plate type Arduino UNO in a toolbar and a serial port COM 3; after the selection is finished, the serial port monitor is opened to confirm that the digit is within +/-0.2, and then the serial port monitor/plotter is closed.
3. Loosening the fastening screws and the limiting screws of the lifting device, adjusting the tray to be flush with the lower part of the opening of the rear wall of the box body, re-fastening, pulling open the push-pull side door of the rear wall, putting the mouse into the box body and closing the side door.
4. And loosening the limit screw of the lifting device, adjusting the lifting device to a set height, and then re-fastening the limit screw of the lifting device.
5. After the test is finished, confirm that data record finishes, close the serial ports and break off the data connection of host computer from top to bottom, adjust elevating gear to the tray and flush the department with back wall opening below, open push-pull side door and take out the mouse, clear up mouse excrement and urine and clear up with alcohol from push-pull side door department.
According to the weight and the body length of the mouse, the stress analysis is carried out on the pressure change caused by the gravity center transfer in the jumping, standing and suspending behaviors of the mouse on the pressure sensor, the pressure data corresponding to the three behaviors of jumping, wall climbing standing and jumping and suspending can be recorded, and the data is provided for the three behaviors of simulating jumping, wall climbing standing and jumping and suspending.
The device of the invention can be used for:
1, automatically recording the number of mouse jumps, the time corresponding to each jump and the latency data of each jump;
2, automatically recording the standing times of the mouse and the standing time of each time;
3, automatically recording the times of the behavior of the mouse jumping to the box cover for suspension and the corresponding duration of each suspension;
and 4, providing data for integrally analyzing behavior tracks of jumping, standing and hanging activities of the mouse in the box body within a period of time.
Claims (10)
1. A mouse jumping recording device is characterized by comprising a box body (1), a box cover (2), a tray (3), a pressure sensor (4) and a controller, wherein the tray (3) is arranged in the box body (1), and the liftable tray (3) is connected with a lifting device (5); pressure sensor (4) set up the bottom surface at tray (3), and pressure sensor (4) connection director's input, controller still connect the host computer through the IO interface, and case lid (2) set up the top at box (1), and the push-and-pull door is seted up to the lateral wall of box (1).
2. The mouse jump recording device according to claim 1, wherein the lifting device (5) is a scissor lift mechanism, a lead screw lift mechanism or an electric push rod lift mechanism; the top of the lifting device is provided with a supporting plate.
3. The mouse jump recording device according to claim 1, wherein the pressure sensor (4) is a beam strain pressure sensor, an analog-to-digital converter is arranged between the pressure sensor and the controller, the pressure sensor (4) is connected with an input end of the analog-to-digital converter, and an output end of the analog-to-digital converter is connected with an input end of the controller.
4. The mouse jump recording device according to claim 1, wherein the case (1) is made of acrylic plate, and the side wall of the case (1) is further provided with reference scale lines.
5. Mouse jump recording device according to claim 1, characterized in that the lowest point height of the tray (3) is not lower than the bottom of the sliding door.
6. Mouse jump recorder according to claim 1, characterized in that the cover (2) is pivotably connected to the housing (1).
7. Mouse jump recorder according to claim 1, characterized in that a locking mechanism is arranged between the cover (2) and the housing (1).
8. The mouse jump recording device according to claim 7, wherein the locking mechanism comprises a slide rail (6) and a slider (7), the slide rail (6) is divided into two parts, which are respectively located on the case cover (2) and the case body (1), and the slider (7) is disposed on the slide rail (6).
9. Mouse jump recorder according to claim 1, characterized in that the cover (2) is provided with a barrier structure.
10. The mouse jump recording device according to claim 1, wherein the controller is a single chip microcomputer, the monitoring precision of the pressure sensor (4) is not lower than 0.1g, and the measurement precision of the ADC is not lower than 0.00033 mV.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202010738909.2A CN111869593B (en) | 2020-07-28 | 2020-07-28 | Mouse jump recording device |
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| CN202010738909.2A CN111869593B (en) | 2020-07-28 | 2020-07-28 | Mouse jump recording device |
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| CN111869593A true CN111869593A (en) | 2020-11-03 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113648503A (en) * | 2021-07-14 | 2021-11-16 | 广州医科大学 | Sleep interference device for rats and mice and use method thereof |
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| CN111869593B (en) | 2022-03-11 |
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