CN111804166B - Anti-leakage low-temperature ingredient production process for suspension soft capsules - Google Patents
Anti-leakage low-temperature ingredient production process for suspension soft capsules Download PDFInfo
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- CN111804166B CN111804166B CN202010837879.0A CN202010837879A CN111804166B CN 111804166 B CN111804166 B CN 111804166B CN 202010837879 A CN202010837879 A CN 202010837879A CN 111804166 B CN111804166 B CN 111804166B
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/50—Mixing liquids with solids
- B01F23/51—Methods thereof
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/50—Mixing liquids with solids
- B01F23/53—Mixing liquids with solids using driven stirrers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/50—Mixing liquids with solids
- B01F23/59—Mixing systems, i.e. flow charts or diagrams
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/83—Mixing plants specially adapted for mixing in combination with disintegrating operations
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/836—Mixing plants; Combinations of mixers combining mixing with other treatments
- B01F33/8361—Mixing plants; Combinations of mixers combining mixing with other treatments with disintegrating
- B01F33/83613—Mixing plants; Combinations of mixers combining mixing with other treatments with disintegrating by grinding or milling
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/80—Forming a predetermined ratio of the substances to be mixed
Abstract
The invention provides a production process of an anti-leakage low-temperature ingredient for a suspension soft capsule, which comprises the following production steps: a. putting the suspending agent and more than one time of oil solution into a mixing tank, heating and stirring, turning off heating when the temperature reaches 60 ℃, and stirring until the suspending agent is completely dissolved; b. pumping the residual oil solution into a batching tank and stirring until the temperature of the mixed solution is reduced to below 30 ℃; c. adding liquid active ingredient materials and lecithin, stopping stirring, adding colloidal silicon dioxide, and starting stirring; d. adding a solid powder material; e. connecting the material mixing tank with a bead mill; f. d, opening a bead mill to cool water, stirring the suspension liquid obtained in the step d, opening a mixing tank, and starting grinding; g. grinding the suspension liquid in the mixing tank, then pumping the liquid back to the mixing tank, continuing stirring, and grinding again; h. the low-temperature grinding material is kept until the material liquid is fine and smooth and has no particles, and a clean stainless steel barrel is used for receiving the material, so that the problem that the suspension soft capsule often leaks can be effectively solved.
Description
Technical Field
The invention relates to the technical field of soft capsule production processes, in particular to a production process of anti-leakage low-temperature ingredients of a suspension soft capsule.
Background
The suspension soft capsule is prepared by mixing solid powder material with oil solution to form suspension liquid, and pressing into soft capsule by a pill press; the main effective components of the feed liquid in the suspension soft capsule are minerals, vitamins, extracts of green fruits and the like, wherein most of the vitamins are afraid of high temperature, the effective components are damaged in a large part after the temperature exceeds 35 ℃, and the low temperature (the temperature is controlled below 35 ℃) is required to be kept during blending so as to keep the effective components from being damaged. When the proportion of solid powder in the suspension liquid exceeds 45%, the liquid has poor fluidity and poor uniform stability due to factors such as high solid content, excessive viscosity, insufficient fineness and the like, so that the pelleting is not smooth, and finally the product is leaked in the drying or storage process.
Most of the existing batching processes mix raw materials and auxiliary materials and then pass through a sand mill, a ball mill and the like, the temperature is not controlled during batching, the temperature of the grinding material is not controlled by using a sand mill, and the fineness of the ground material liquid can only pass through a 50-mesh filter screen. Only a small amount of suspending agent and lubricant are added into the prepared feed liquid, the feed liquid is prepared, the stability is poor, the feed liquid can be layered after being placed for 2 hours, the viscous feed liquid can be heated to enable the feed liquid to smoothly flow in a pump body, a material injection pipe and a spraying body of a pelleting press, the ground feed liquid is not fine and smooth enough, the number of passing filter screens is less than 100 meshes, and some materials are easy to agglomerate when the temperature is raised, so that the grinding cannot be continued; the addition proportion of auxiliary components such as a suspending agent, a lubricant and the like during suspension compounding influences the stability of a suspension liquid, improper proportioning can cause the liquid to be divided into too thick liquid with poor fluidity and can not be used for pelleting and the like, a common grinding machine is not provided with a temperature control device, the fineness of the ground liquid is limited, the fineness can not reach a nanometer level, and some solid powder materials are granular, flaky and crystalline and can be agglomerated after being mixed with oily components such as soybean oil and the like. Because the temperature is not controlled, the effective ingredients in the vitamin materials are easy to damage, and the suspension liquid has poor fluidity, large viscosity, poor uniform stability and easy layering; the feed liquid has small particles and can not pass through a 100-mesh filter screen and the like.
The above reasons all cause the leakage phenomenon of the suspension products after being pressed into finished products and stored for a period of time, so that the product quality is reduced, and the product sale and eating are influenced, therefore, a suspension soft capsule leakage-prevention low-temperature ingredient production process must be developed to solve the problem that the content of solid powder ingredients in suspension liquid of the suspension soft capsule exceeds 45 percent or the effective ingredients in the liquid are corroded and the rubber skin of the suspension soft capsule can leak.
Disclosure of Invention
In order to solve some technical problems in the prior art, the invention provides a production process of anti-leakage low-temperature ingredients of suspension soft capsules, which can effectively solve the problem that the suspension soft capsules often leak.
In order to solve the above-mentioned existing technical problem, the invention adopts the following scheme:
a suspension soft capsule anti-leakage low-temperature ingredient production process comprises the following steps:
a. putting the suspending agent and more than one time of oil solution into a mixing tank, starting heating and stirring, stopping heating when the temperature of the mixing tank reaches 60 ℃, and continuously stirring until the suspending agent is completely dissolved;
b. pumping the residual oil solution into the batching tank through a vacuum and pumping pipe, continuously stirring, starting the batching tank, cooling and reducing the temperature to reduce the temperature of the mixed solution of the suspending agent and the oil solution in the batching tank to below 30 ℃;
c. adding liquid active ingredient materials and lecithin into the feed inlet at the upper part of the batching tank, stirring for 10 minutes, then closing the stirring, adding colloidal silicon dioxide into the feed inlet at the upper part of the batching tank, and continuing to start stirring;
d. adding solid powder materials from a feeding port at the upper part of the batching tank for multiple times, adding 1-2 materials each time, closing stirring before adding, starting stirring immediately after adding, and continuously stirring the suspension liquid;
e. a discharge hole at the bottom of the batching tank is connected with a feed inlet of the bead mill through a feeding hose;
f. d, opening the cooling water of the bead mill, setting the upper limit of the discharge temperature of the bead mill to be 30 ℃, stirring the suspension liquid obtained in the step d for 30 minutes, opening a discharge valve at the bottom of the batching tank, and starting grinding;
g. grinding the suspension liquid in the mixing tank, then pumping the liquid back to the mixing tank, continuing stirring, and grinding again;
h. and (3) keeping low-temperature grinding until the material liquid is fine and smooth and has no particles, wherein the material liquid can pass through a 100-mesh filter screen at least, and is filtered through a 100-mesh or more-than-100-mesh filter screen during the last grinding, and a clean stainless steel barrel is used for receiving materials to obtain the suspension material liquid with the flowability, the viscosity, the fineness and the uniformity meeting the requirements.
Furthermore, when the fluidity of the suspension liquid is poor, a proper amount of lecithin is added, so that the lubrication effect is realized to increase the fluidity of the suspension liquid, and the liquid is ensured not to flow in a pump body, a material injection pipe and a spray body of the pelleting press and not to trail.
Further, a small amount of colloidal silicon dioxide is added when the viscosity of the suspension liquid is too high, so that the using amount of a suspending agent is reduced, the viscosity of the suspension liquid is reduced, the liquid is ensured to flow in a pump body, a material injection pipe and a spraying body of the pellet press without trailing, and the pump body, the material injection pipe and the spraying body of the pellet press cannot be blocked.
Further, when the suspension liquid has the lowest fineness and can not pass through a 100-mesh filter screen, the suspension liquid passes through a bead mill and is repeatedly ground, so that the suspension liquid is fine and smooth and can smoothly pass through the 100-mesh filter screen and above, and the suspension liquid is ensured not to have fine particles clamped at the joint of rubber during pelleting and injecting.
Furthermore, when the suspension liquid can be layered in a short time, the dosage of the suspending agent is increased, and the liquid can not be layered when being pressed into pills.
Furthermore, when the solid content of the suspension is higher than 50%, the specification of the solid powder material is adjusted, and the material with higher content of effective components and lower relative dosage or liquid material is selected to ensure the stability of the material liquid and ensure that the material liquid can smoothly flow in a pump body, a material injection pipe and a spray body of the pelleting press.
Further, the suspending agent comprises beeswax and the oil solution comprises one or more of soybean oil, sunflower oil, safflower oil or linseed oil.
Further, the discharge port of the bead mill receives the ground material by using a stainless steel bucket.
Compared with the prior art, the invention has the beneficial effects that:
the proportion of auxiliary components beeswax, lecithin and colloidal silicon dioxide in the suspension liquid is adjusted, so that the liquid has good fluidity and uniform stability, the material is ground by using a bead mill, the grinding temperature of the liquid is controllable, the rotating speed of the bead mill can be adjusted, the low temperature (below 35 ℃) is kept for batching, effective components can be effectively prevented from being damaged, the fineness of the liquid can at least reach a filter screen with 100 meshes or more, the mesh number of the filter screen through which the fineness of the ground liquid can pass is high, the proportion of a suspending agent and a lubricating agent is reasonably adjusted, so that the liquid has good fluidity and stability, the liquid flows smoothly in a pump body, a material injection pipe and a spray body of a pill press, the trailing phenomenon is avoided, the liquid is not layered, and the pill press is easy.
Detailed Description
The present invention is further described below with reference to specific embodiments, and it should be noted that, without conflict, any combination between the embodiments or technical features described below may form a new embodiment.
The production process of the anti-leakage low-temperature ingredient production process of the suspension soft capsule comprises the following production steps:
a. putting the suspending agent and more than one time of oil solution into a mixing tank, starting heating and stirring, stopping heating when the temperature of the mixing tank reaches 60 ℃, and continuously stirring until the suspending agent is completely dissolved;
b. pumping the residual oil solution into the batching tank through a vacuum and pumping pipe, continuously stirring, starting the batching tank, cooling and reducing the temperature to reduce the temperature of the mixed solution of the suspending agent and the oil solution in the batching tank to below 30 ℃;
c. adding liquid active ingredient materials and lecithin into the feed inlet at the upper part of the batching tank, stirring for 10 minutes, then closing the stirring, adding colloidal silicon dioxide into the feed inlet at the upper part of the batching tank, and continuing to start stirring;
d. adding solid powder materials from a feeding port at the upper part of the batching tank for multiple times, adding 1-2 materials each time, closing stirring before adding, starting stirring immediately after adding, and continuously stirring the suspension liquid;
e. a discharge hole at the bottom of the batching tank is connected with a feed inlet of the bead mill through a feeding hose;
f. d, opening the cooling water of the bead mill, setting the upper limit of the discharge temperature of the bead mill to be 30 ℃, stirring the suspension liquid obtained in the step d for 30 minutes, opening a discharge valve at the bottom of the batching tank, and starting grinding;
g. grinding the suspension liquid in the mixing tank, then pumping the liquid back to the mixing tank, continuing stirring, and grinding again;
h. and (3) keeping low-temperature grinding until the material liquid is fine and smooth and has no particles, wherein the material liquid can pass through a 100-mesh filter screen at least, and is filtered through a 100-mesh or more-than-100-mesh filter screen during the last grinding, and a clean stainless steel barrel is used for receiving materials to obtain the suspension material liquid with the flowability, the viscosity, the fineness and the uniformity meeting the requirements.
As further optimization, when the fluidity of the suspension liquid is poor, a proper amount of lecithin is added, so that the lubrication effect is realized to increase the fluidity of the suspension liquid, and the smooth flowing and no tailing of the liquid in a pump body, a material injection pipe and a spraying body of the pelleting press are ensured.
The lecithin which is added by 2% -10% when the fluidity of the suspension liquid is poor plays a role in lubrication so as to increase the fluidity of the suspension liquid, so that the problems that when the fluidity of the liquid is poor, the injection cannot be completed instantly, the injection is not completed when the two-petal rubber is closed, and the liquid is clamped into the bonding part of the two-petal rubber to cause incomplete bonding of the rubber and leakage are solved. The material pipe is ensured to be smooth and not blocked, and the material injection can be instantly finished before the two sections of rubber sheets are closed. If the material liquid flows unsmoothly, the material injection is still not completed when the rubber is closed, so that the material liquid is clamped at the closed position of the rubber, the rubber is not bonded completely, and the leakage exists in the subsequent placing process.
As a further optimization, a small amount of colloidal silica is added when the viscosity of the suspension liquid is too high, so that the using amount of the suspending agent is reduced, the viscosity of the suspension liquid is reduced, the smooth flowing and no tailing of the liquid in a pump body, a material injection pipe and a spraying body of the pelleting press are ensured, and the pump body, the material injection pipe and the spraying body of the pelleting press cannot be blocked.
Specifically, when the viscosity of the suspension liquid is too high, 0.5% -2% of colloidal silicon dioxide is added, the using amount of beeswax serving as a suspending agent is synchronously reduced from 3% -5%, and the viscosity of the suspension liquid is reduced, so that the problems that when the viscosity of the liquid is high, residual liquid is attached to a material injection spray hole when material injection is finished, and when two flaps of rubber are closed, the residual liquid at the material injection spray hole is clamped into the bonding position of the two flaps of rubber to cause incomplete rubber bonding and leakage are solved.
As a further optimization, when the suspension liquid has the lowest fineness and can not pass through a 100-mesh filter screen, the suspension liquid passes through a bead mill and is repeatedly ground, so that the suspension liquid is fine and smooth and can smoothly pass through the 100-mesh filter screen and above, and the suspension liquid is ensured not to have fine particles clamped at the joint of the rubber when being pressed into pills and injected.
Specifically, when the small particles are clamped into the bonding part of the two-piece rubber during material injection, the rubber is bonded insecurely, and after the rubber is dried, the bonding part is pulled due to the shrinkage of the rubber, and the bonding insecurely forms a pinhole due to pulling force, so that the problem of chronic leakage is caused.
As a further optimization, when the suspension liquid can be layered in a short time, the dosage of the suspending agent is increased, and the liquid can not be layered when being pressed into pills.
As further optimization, when the solid content of the suspension liquid is higher than 50%, the specification of the solid powder material is adjusted, and the material with higher content of effective components and lower relative dosage or liquid material is selected, so that the stability of the liquid material is ensured, and the smooth flow of the liquid material in a pump body, a material injection pipe and a spraying body of the pelleting press is ensured.
When the suspension liquid reacts with the rubber to erode the rubber, 3% -8% of the anti-erosion composition is added to solve the problem that the effective component in the liquid is the rubber which is eroded by the chronic state to cause the rubber to be perforated to cause leakage, and the anti-erosion composition is obtained by mixing and grinding 35% of PC phospholipid and microcrystalline cellulose according to the proportion of 7: 3.
As a further optimization, the suspending agent comprises beeswax, and the oil solution comprises one or more of soybean oil, sunflower oil, safflower oil, or linseed oil; the suspending agent is common suspending agent such as yellow beeswax, and mono-diglycerol fatty acid ester.
As a further optimization, the discharge port of the bead mill uses a stainless steel bucket to receive the ground material.
After the technology is improved, the proportion of auxiliary components beeswax, lecithin and colloidal silicon dioxide in the suspension liquid is adjusted, so that the liquid has good fluidity and uniform stability, the material is ground by using a bead grinding machine, the grinding temperature of the liquid is controllable, the rotating speed of the bead grinding machine can be adjusted, the low temperature (below 35 ℃) is kept for batching, the effective components can be effectively prevented from being damaged, the fineness of the liquid can at least reach the level of 100 meshes and above of a filter screen, the number of the filter screens through which the fineness of the ground liquid can pass is high, the proportion of a suspending agent and a lubricating agent is reasonably adjusted, so that the liquid has good fluidity and stability, and the liquid flows smoothly and does not trail in a pump body, a material injection pipe and a spray body of a pelleting press, the liquid is not layered.
The raw materials used in the following examples are all commercially available, the soft capsule pellets of the following examples are pressed by a pellet press, the content of the pellets is suspension liquid mainly containing mineral materials, the rubber is transparent rubber, the pressing specification is 1000 mg/pellet, and the pressed pellets are dried in a rotating cage to obtain the dried suspension soft capsules.
The embodiment of the invention provides a specific implementation mode of an anti-leakage low-temperature ingredient production process of a suspension soft capsule, which comprises the following specific steps:
example 1
Preparing 20kg of suspension liquid, wherein the components account for the total weight ratio: the proportion of solid powder material is 51 percent, the proportion of oily material is 42.2 percent, the proportion of lecithin is 3.8 percent, the proportion of beeswax is 3 percent, and the proportion of colloidal silicon dioxide is 0 percent.
Suspension soft capsules were prepared as described in example 1, and the pressed pellets were dried and subjected to an acceleration test, with the results shown in Table 1.
Example 2
Preparing 20kg of suspension liquid, wherein the components account for the total weight: the proportion of solid powder material is 51 percent, the proportion of oily material is 41 percent, the proportion of lecithin is 5 percent, the proportion of beeswax is 3 percent, and the proportion of colloidal silicon dioxide is 0 percent.
Suspension soft capsules were prepared as described in example 2, and the pressed pellets were dried and subjected to an acceleration test, with the results shown in Table 1.
Example 3
Preparing 20kg of suspension liquid, wherein the components account for the total weight ratio: the proportion of solid powder material is 51 percent, the proportion of oily material is 40.2 percent, the proportion of lecithin is 5 percent, the proportion of beeswax is 2.3 percent, and the proportion of colloidal silicon dioxide is 1.5 percent.
Suspension soft capsules were prepared as described in example 3, and the pressed pellets were dried and subjected to an acceleration test, with the results shown in Table 1.
Example 4
Preparing 20kg of suspension liquid, wherein the components account for the total weight ratio: the proportion of solid powder material is 51 percent, the proportion of oily material is 39.2 percent, the proportion of lecithin is 6 percent, the proportion of beeswax is 2.3 percent, and the proportion of colloidal silicon dioxide is 1.5 percent.
Suspension soft capsules were prepared as described in example 4, and the pressed pellets were dried and subjected to an acceleration test, with the results shown in Table 1.
Example 5
Preparing 20kg of suspension liquid, wherein the active ingredient materials contain potassium iodide or vitamin materials, and the liquid erodes the rubber, and the components account for the total weight ratio: the proportion of solid powder material is 51 percent, the proportion of oily material is 36.2 percent, the proportion of lecithin is 6 percent, the proportion of beeswax is 2.3 percent, the proportion of colloidal silicon dioxide is 1.5 percent, and the proportion of anti-corrosion composition is 3 percent.
Suspension soft capsules were prepared as described in example 5, and the pressed pellets were dried and subjected to an acceleration test, with the results shown in Table 1.
Example 6
Preparing 20kg of suspension liquid, wherein the active ingredient materials contain potassium iodide or vitamin materials, and the liquid erodes the rubber, and the components account for the total weight ratio: the proportion of solid powder material is 51 percent, the proportion of oily material is 35.2 percent, the proportion of lecithin is 5 percent, the proportion of beeswax is 2.3 percent, the proportion of colloidal silicon dioxide is 1.5 percent, and the proportion of anti-corrosion composition is 5 percent.
Suspension soft capsules were prepared as described in example 6, and the pressed pellets were dried and subjected to an acceleration test, with the results shown in Table 1.
The embodiment of the invention is used for making a comparative example, and the steps are as follows:
comparative example 1
Preparing 20kg of suspension liquid, wherein the components account for the total weight ratio: 50% of solid powder material, 44.2% of oily material, 3.8% of lecithin, 2% of beeswax and 0% of colloidal silicon dioxide.
Suspension soft capsules were prepared in the comparative examples, and the pressed pellets were dried and subjected to an accelerated test, with the results shown in table 1.
Comparative example 2
Preparing 20kg of suspension liquid, wherein the active ingredient materials contain potassium iodide or vitamin materials, and the liquid erodes the rubber, and the components account for the total weight ratio: the proportion of solid powder material is 51 percent, the proportion of oily material is 39.2 percent, the proportion of lecithin is 6 percent, the proportion of beeswax is 2.3 percent, the proportion of colloidal silicon dioxide is 1.5 percent, and the proportion of anti-corrosion composition is 0 percent.
Suspension soft capsules were prepared in the comparative examples, and the pressed pellets were dried and subjected to an accelerated test, with the results shown in table 1.
TABLE 1
As shown in table 1, in examples 1 to 4, compared with comparative example 1, when the content of solid powder in the suspension is higher, the auxiliary ingredients such as lecithin, beeswax and colloidal silica in the suspension are adjusted to a proper ratio, and then the suspension is efficiently ground by a grinder, so that the fluidity, viscosity and fineness of the suspension are all favorable for pelleting, and the phenomenon of leakage of the pressed suspension soft capsules is avoided.
Examples 5 to 6 compared with comparative example 2, when the suspension liquid contains both the mineral material and the vitamin material or potassium iodide, the liquid erodes the gelatin skin, so that the gelatin skin slowly forms fine perforations to leak, and the anti-erosion composition added in a proportion of 5% or more can effectively prevent the liquid from eroding the gelatin skin, so as to ensure that the compressed suspension soft capsule does not leak.
The above embodiments are only preferred embodiments of the present invention, and the protection scope of the present invention is not limited thereby, and any insubstantial changes and substitutions made by those skilled in the art based on the present invention are within the protection scope of the present invention.
Claims (8)
1. The anti-leakage low-temperature burdening production process of the suspension soft capsule is characterized by comprising the following steps of:
a. putting the suspending agent and more than one time of oil solution into a mixing tank, starting heating and stirring, stopping heating when the temperature of the mixing tank reaches 60 ℃, and continuously stirring until the suspending agent is completely dissolved;
b. pumping the residual oil solution into the batching tank through a vacuum and pumping pipe, continuously stirring, starting the batching tank, cooling and reducing the temperature to reduce the temperature of the mixed solution of the suspending agent and the oil solution in the batching tank to below 30 ℃;
c. adding liquid active ingredient materials and lecithin into the feed inlet at the upper part of the batching tank, stirring for 10 minutes, then closing the stirring, adding colloidal silicon dioxide into the feed inlet at the upper part of the batching tank, and continuing to start stirring;
d. adding solid powder materials from a feeding port on the upper part of the batching tank for multiple times, closing stirring before adding, starting stirring immediately after adding, and continuously stirring the suspension liquid;
e. a discharge hole at the bottom of the batching tank is connected with a feed inlet of the bead mill through a feeding hose;
f. d, opening the cooling water of the bead mill, setting the upper limit of the discharge temperature of the bead mill to be 30 ℃, stirring the suspension liquid obtained in the step d for 30 minutes, opening a discharge valve at the bottom of the batching tank, and starting grinding;
g. grinding the suspension liquid in the mixing tank, then pumping the liquid back to the mixing tank, continuing stirring, and grinding again;
h. the low-temperature grinding is kept until the material liquid is fine and smooth and has no particles, the material liquid can pass through a 100-mesh filter screen at the lowest, the material liquid is filtered through a 100-mesh filter screen or a filter screen with more than 100 meshes during the last grinding, a clean stainless steel barrel is used for receiving the material liquid, the suspension material liquid with the flowability, the viscosity, the fineness and the uniformity meeting the requirements is obtained, when the suspension material liquid reacts with the rubber to erode the rubber, 3% -8% of an anti-erosion composition is added, so that the problem that the rubber is perforated and leaks due to the fact that the rubber is eroded in the chronic state by the active ingredients in the material liquid is solved, and the anti-erosion composition is obtained after 35% of PC phospholipid and microcrystalline cellulose.
2. The production process of the suspension soft capsule anti-leakage low-temperature ingredient as claimed in claim 1, wherein the production process comprises the following steps: when the fluidity of the suspension liquid is poor, a proper amount of lecithin is added, so that the lubrication effect is realized to increase the fluidity of the suspension liquid, and the liquid is ensured not to flow and trailing in a pump body, a material injection pipe and a spraying body of the pelleting press.
3. The production process of the suspension soft capsule anti-leakage low-temperature ingredient as claimed in claim 1, wherein the production process comprises the following steps: when the viscosity of the suspension liquid is too high, a small amount of colloidal silicon dioxide is added, so that the using amount of a suspending agent is reduced, the viscosity of the suspension liquid is reduced, the liquid is ensured to smoothly flow in a pump body, a material injection pipe and a spray body of the pelleting press, and the pump body, the material injection pipe and the spray body of the pelleting press cannot be blocked.
4. The production process of the suspension soft capsule anti-leakage low-temperature ingredient as claimed in claim 1, wherein the production process comprises the following steps: when the suspension liquid has the lowest fineness and can not pass through a 100-mesh filter screen, the suspension liquid passes through a bead mill and is repeatedly ground, so that the suspension liquid is fine and smooth and can smoothly pass through the 100-mesh filter screen and above, and fine particles of the suspension liquid can not be clamped at the joint of the rubber when the suspension liquid is pressed into pills and injected.
5. The production process of the suspension soft capsule anti-leakage low-temperature ingredient as claimed in claim 1, wherein the production process comprises the following steps: when the suspension liquid can be layered in a short time, the dosage of the suspending agent is increased, and the liquid can not be layered when being pressed into pills.
6. The production process of the suspension soft capsule anti-leakage low-temperature ingredient as claimed in claim 1, wherein the production process comprises the following steps: when the solid content of the suspension is higher than 50%, the specification of solid powder materials is adjusted, and materials with higher content of effective components and lower relative dosage or liquid materials are selected to ensure the stability of the material liquid and ensure that the material liquid can smoothly flow in a pump body, a material injection pipe and a spray body of the pelleting press.
7. The production process of the suspension soft capsule anti-leakage low-temperature ingredient as claimed in claim 1, wherein the production process comprises the following steps: the suspending agent comprises beeswax and the oil solution comprises one or more of soybean oil, sunflower seed oil, safflower seed oil or linseed oil.
8. The production process of the suspension soft capsule anti-leakage low-temperature ingredient as claimed in claim 1, wherein the production process comprises the following steps: the discharge port of the bead mill receives the ground material by using a stainless steel charging bucket.
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