CN111773268A

CN111773268A - External ointment for treating hyperosteogeny

Info

Publication number: CN111773268A
Application number: CN202010774722.8A
Authority: CN
Inventors: 曹崇维
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-08-04
Filing date: 2020-08-04
Publication date: 2020-10-16

Abstract

The invention provides an external ointment for treating hyperosteogeny, which is prepared from 600 g of mirabilite and 300 g of safflower, belongs to 200 g of fulgerian palm, 600 g of fulgerian eyeball and 200 g of pseudo-ginseng.

Description

External ointment for treating hyperosteogeny

Technical Field

The invention belongs to the technical field of traditional Chinese medicine preparation, and particularly relates to an external ointment for treating hyperosteogeny and a preparation method thereof.

Background

Hyperosteogeny (also called osteophyte, bony spur or wart) and proliferative arthropathy are common degenerative diseases of human body, and the pathogenesis is mainly related to chronic injury and strain and senile tissue degeneration. The disease is more frequent in the late-year and old people, and according to the data of the world health organization, osteoporosis is a global health problem, the severity of osteoporosis is second to cardiovascular diseases, and the disease threatens more than common diseases such as breast cancer, prostate cancer and the like. Of the worldwide older people 50 years old, 1/3 women and 1/5 men are at risk for osteoporosis. In recent years, the onset of diseases has a trend of gradual rejuvenation, and the hyperosteogeny has attracted more and more attention.

The plaster is firstly called as 'thin plaster', and the Chinese era is called as 'plaster' to 'external treatment method'. "Huatuo Shen Gao" in the Han Dynasty is a paste for treating sore and wound, and the "Liyu He Wen" compiled by Wu Master in the Qing Dynasty has further elaboration on the plaster. The book is a famous Chinese plaster monograph and proposes a famous theory of 'first-pull and first-cut'. The disease comes out when the plaster is pulled out, and the pathogen breaks off when the plaster is stopped, so the scientific conclusion of the plaster plays a reference role in later development and application of the plaster. Different types of plasters or patches are manufactured in all times of the past generation. The plaster belongs to one of transdermal absorption preparations, has the advantages of transdermal absorption and is mainly shown in the following points:

(1) the medicine absorption is not influenced by the pH in the digestive tract, food, the moving time of the medicine in the intestinal tract and other complex factors;

(2) the first pass effect of the medicine in the liver is avoided, and the bioavailability is improved;

(3) the drug administration speed can be continuously controlled;

(4) the peak valley phenomenon can be avoided, and the toxic and side effects of the medicine can be reduced;

(5) can generate lasting, constant and controllable blood concentration, thereby improving the curative effect and lightening the adverse reaction;

(6) avoiding pain during injection;

(7) reducing the number of administrations and dosage;

(8) the medicine is applied on the body surface, so that the medicine administration can be interrupted at any time and is easy to be accepted by patients.

In this respect, the technical scheme of the invention is successfully created based on the purpose of radical cure of the stubborn diseases, and the external plaster is prepared by compatibility of Chinese herbal medicines such as safflower, belonging to the palm of the fulgerian, fulgerian eyeball and the like, so as to improve the cure rate, relieve pathological symptoms, improve the bioavailability of the medicine, and take the medicine conveniently and the like as evaluation indexes.

Disclosure of Invention

The invention aims to provide an external ointment for treating hyperosteogeny. The invention also aims to provide a preparation method of the external ointment. The external ointment of the invention comprises the following components in proportion: 600 g of mirabilite and 300 g of safflower, which belong to 200 g of fulgerian palm, 600 g of fulgerian eyeball and 200 g of pseudo-ginseng. The preparation method of the externally applied ointment provided by the invention comprises the following operation steps: (1) grinding Natrii sulfas and Carthami flos belonging to Fossilia Armaturus and Notoginseng radix into powder, sieving with 120 mesh sieve, and keeping;

(2) cleaning the palm of the patient belonging to the genus Viburnum, boiling at 80-90 ℃ for 1.5 hours, juicing, adding the ground powder obtained in the step (1), and slowly boiling at 50-60 ℃ to obtain the ointment.

The traditional Chinese medicine composition in the technical scheme is added with common pharmaceutic adjuvants and can be prepared into an external patch according to a conventional technical method, and the method comprises the following specific steps: mixing 8-12kg of honey, 4-8kg of lanolin, 3-5kg of glycerin and 100-300ml of azone, adding the paste prepared in the step (2), fully stirring and uniformly mixing, standing for 48h, pressing tablets with the thickness of 1-2mm by using a tablet press, and adding the tablets to a non-woven fabric adhesive plaster to obtain the external patch.

In the plaster formula of the invention: mirabilite: purging heat, relaxing bowels, moistening dryness, softening hard masses, clearing pathogenic fire, and relieving swelling, and can be used for treating excess heat constipation, intestinal abscess, swelling and pain, and abdominal pain; for acute mastitis, hemorrhoid with swelling, pain, salty, bitter and cold taste. The meridian tropism enters stomach and large intestine meridians.

Safflower: promoting blood circulation, removing blood stasis, and relieving pain. Can be used for treating amenorrhea, dysmenorrhea, lochiorrhea, abdominal mass, and traumatic injury. When ancient people often had blood in the body, a small handle of safflower is often added, and gauze bags can be boiled for soaking feet twice a day, and are suitable for various varicose veins, peripheral neuritis and blood circulation. Activating blood and meridian; dispel blood stasis and alleviate pain, hong Hua is pungent in flavor and warm in nature, and enters heart and liver meridians. The powder has the effects of activating blood circulation to promote menstruation, removing blood stasis and relieving pain, and is mainly used for treating dysmenorrhea, amenorrhea, postpartum anemic fainting, stasis and abdominal pain, chest stuffiness and pains, blood stasis, traumatic injury and blood stasis and swelling, arthralgia, stroke paralysis and porphyria.

Cactus: promoting qi and blood circulation, cooling blood to stop bleeding, removing toxic substance and relieving swelling, and can be used for treating stomach ache, lump in the abdomen, dysentery, laryngalgia, cough due to lung heat, tuberculosis, hemoptysis, hematemesis, hemorrhoidal bleeding, pyocutaneous disease, furuncle, etc., with bitter taste, and cold nature, and entering stomach, lung and large intestine meridians.

Bullseye: clearing and activating the channels and collaterals; relieving swelling and pain. Chief wind-damp arthralgia; numbness of hands and feet; hemiplegia; abscess, deep-rooted carbuncle and pyogenic infections; traumatic injury, bitter in nature and taste; cold in nature; it is toxic.

Pseudo-ginseng: it is warm in nature and pungent in flavor, entering liver meridian of foot jueyin. Has effects of promoting blood circulation, dispelling blood stasis, relieving swelling and relieving pain. It is mainly used for treating hemorrhagic diseases such as hemoptysis, hematemesis, hematochezia, metrorrhagia, traumatic hemorrhage, etc. Tianqi stops bleeding, dispels blood and relieves pain.

The invention has clear treatment rules of the formula, reasonable compatibility and synergistic effect of all the medicines, and has the effects of clearing fire, reducing swelling, dissipating blood stasis, relieving pain, clearing and activating the channels and collaterals, moistening dryness, softening hard masses, treating traumatic injury and the like.

Detailed Description

Example 1

An externally-applied ointment for treating hyperosteogeny comprises the following components in percentage by weight: 600 g of mirabilite and 300 g of safflower, which belong to 200 g of fulgerian palm, 600 g of fulgerian eyeball and 200 g of pseudo-ginseng.

The preparation method of the externally applied ointment provided by the invention comprises the following operation steps: (1) grinding Natrii sulfas and Carthami flos belonging to Fossilia Armaturus and Notoginseng radix into powder, sieving with 120 mesh sieve, and keeping;

(2) cleaning the palm of the patient belonging to the genus Viburnum, boiling at 80-90 ℃ for 1.5 hours, juicing, adding the ground powder obtained in the step (1), and slowly boiling at 50-60 ℃ to obtain the ointment. The application method comprises applying on affected part, cleaning affected part skin with Chinese liquor, wrapping with gauze to form rectangle of about 10-15Cm, applying on affected part, changing once in 15 days, and taking 75 days as a treatment course to achieve healing, contraindication, and bathing during application.

Example 2

For convenient use, the external patch can be prepared according to a conventional technical method, and comprises the following specific steps: mixing 8-12kg of honey, 4-8kg of lanolin, 3-5kg of glycerin and 100-300ml of azone, adding the paste prepared in the step (2), fully stirring and uniformly mixing, standing for 48h, pressing the mixture to a tablet with the thickness of 1-2mm by using a tablet press, and adding the tablet to a non-woven fabric adhesive patch to obtain the external patch, wherein the proportion of the rest steps and the formula is the same as that of the example 1.

Safety test

Selecting 50 volunteers aged 20-50 years, marking 5 × 5cm area on inner side of left forearm of volunteer, sterilizing with 75% alcohol, introducing the paste into tested area with 36-needle micro needle for 30s, gently wiping residual liquid with medical cotton ball soaked with physiological saline, and keeping tested area dry; the number of the spot tester cells is 1-6, and the test sample (the composition prepared in example 1) is respectively put into the spot tester cells with the corresponding number, and the dosage is 0.02g per cell; the spot tester is pasted on the part marked with the wound, after 24h of waterproof pasting, the spot tester is removed, the skin condition of the wound part is observed, and the safety verification result is obtained, as shown in table 2:

table 2: composition safety test

According to the safety verification result, the ointment prepared from the formula and the raw materials adopted by the technical scheme of the invention has no irritation to the skin of a human body and does not cause anaphylactic reaction.

And (3) validity verification:

patient data:

100 cases of knee joint hyperosteogeny, 80 cases of lumbar vertebra hyperosteogeny and 80 cases of cervical vertebra hyperosteogeny are selected in various hospitals. There were 260 patients, 160 men and 100 women. The maximum age is 70 years, the minimum age is 35 years, and the average age is 49.2 years. The longest course is 14 years, the shortest course is 5 months, and the average course is 5.8 years. The clinical manifestations are as follows: the affected part of most patients has chronic pain, part of patients with cervical vertebra hyperplasia have radiation pain towards the occipital part and are accompanied with abnormal feelings such as cold and numbness, and part of patients with cervical vertebra hyperplasia have vegetative nerve functional disturbance, such as symptoms of nausea, dizziness, tinnitus, and the like. In addition, some patients have more obvious muscle spasm or muscle tension at the pain part.

The treatment method comprises the following steps:

dividing 260 patients into 3 groups on average, wherein each group selects 10 knee joint hyperosteogeny, 10 lumbar vertebra hyperosteogeny and 10 cervical vertebra hyperosteogeny as a contrast; group 1 of 3 groups served as control group, and group 2 and 3 served as treatment group. The control group takes daily oral administration medicine, GUCIPING tablet, 5 tablets at a time, 3 times a day; the traditional Chinese medicine ointment prepared in the embodiment 1 and the embodiment 2 is pasted on an affected part, and is replaced once in 15 days, and 75 days is a treatment course; both the control and treatment groups were treated continuously for 75 days.

And (3) evaluating the curative effect:

it is classified as ineffective, effective, significant and healing. The effective rate plus the significant rate plus the cure rate is the total effective rate. And (4) invalidation: before and after treatment, symptoms and signs do not change or the disease condition is aggravated. Secondly, the method is effective: symptoms and signs improve to a limited extent, and function recovers to a limited extent. ③ is remarkable: symptoms and signs basically disappear, the function returns to normal, but discomfort still occurs due to weather change or fatigue and the like. Fourthly, healing: the symptoms and signs disappear completely, and the function returns to normal completely.

TABLE 1 statistics of treatment efficacy for each group

As can be seen from the curative effect experiment, the curative effect of the invention is greater than other therapeutic drugs, and is superior to the curative effect of the traditional Chinese medicine prepared by similar formula in the prior art, especially the best effect is obtained in the embodiment 1, so the invention has the advantages of lasting efficacy, mild curative effect, obvious curative effect and high safety, is especially suitable for middle-aged and elderly patients, and is worthy of clinical application and popularization.

Claims

1. An external ointment for treating hyperosteogeny is characterized by being prepared from the following raw material medicines by weight: 600 g of mirabilite and 300 g of safflower, which belong to 200 g of fulgerian palm, 600 g of fulgerian eyeball and 200 g of pseudo-ginseng.

2. A method for preparing the external ointment for treating hyperosteogeny according to claim 1, which comprises: (1) grinding Natrii sulfas and Carthami flos belonging to Fossilia Armaturus and Notoginseng radix into powder, sieving with 120 mesh sieve, and keeping;

cleaning the palm of the patient belonging to the genus Viburnum, boiling at 80-90 ℃ for 1.5 hours, juicing, adding the ground powder obtained in the step (1), and slowly boiling at 50-60 ℃ to obtain the ointment.

3. The method for preparing an external ointment for the treatment of hyperosteogeny according to claim 2, wherein: mixing 8-12kg of honey, 4-8kg of lanolin, 3-5kg of glycerin and 100-300ml of azone, adding the paste prepared in the step (2), fully stirring and uniformly mixing, standing for 48h, pressing tablets with the thickness of 1-2mm by using a tablet press, and adding the tablets to a non-woven fabric adhesive plaster to obtain the external patch.