CN111759922A - Traditional Chinese medicine composition for treating gout and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for treating gout and preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating gout and a preparation method and application thereof, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 6-12 parts of angelica sinensis, 3-10 parts of ligusticum wallichii, 15-30 parts of Chinese violet, 15-30 parts of dandelion, 3-9 parts of corydalis amabilis, 5-12 parts of achyranthes bidentata, 10-15 parts of desmodium, 3-10 parts of notopterygium root, 3-10 parts of myrobalan and 1-3 parts of catechu. The traditional Chinese medicine composition can relieve red swelling and hot pain in the acute gout attack stage, reduce the blood uric acid level, effectively control the recurrence of gout and reduce the occurrence probability of other complications.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating gout and a preparation method and application thereof.
Background
Gout is a heterogeneous chronic metabolic disease in which tissue damage is caused by purine metabolic disorder or uric acid excretion disorder due to various causes, and is also called hyperuricemia. Gout is divided into acute gout and chronic gout according to clinical symptoms, wherein the acute gout has sudden attack, can be induced by trauma, operation, excessive drinking and other reasons, and the gouty arthritis is taken as a clinical manifestation, and the normal life is seriously influenced by red swelling, fever, obvious tenderness, limited joint activity and the like. At present, the pathogenesis of gout is not completely disclosed, and gout cannot be completely cured, and long-term comprehensive treatment is mainly carried out by combining uric acid reduction and anti-inflammatory analgesic drugs to control diet.
At present, colchicine is mainly used as a first choice medicine for treating acute gout attack clinically. However, colchicine has high toxicity and many adverse reactions, and can cause symptoms such as nausea, vomiting, diarrhea and the like. And other non-steroidal anti-inflammatory drugs such as ibuprofen and diclofenac diethylamine are combined to be used as therapeutic drugs for relieving acute attack inflammation of gout, and uric acid reducing drugs are supplemented to reduce uric acid after acute symptoms are relieved, so that the non-steroidal anti-inflammatory drugs can cause more complications and adverse reactions and bring great pain to patients.
There is also the name of gout in TCM, and doctors in all ages discuss it. The causes of gout are divided into internal and external causes. The deficient essence and blood due to intrinsic factors are deficient liver and kidney, which results in malnutrition of the muscles and bones. Externally, it is caused by wind, cold and dampness, and remains in the limbs, bones and muscles and joints to block qi and blood in the channels; in addition, the ointment is thick in flavor, alcohol is drunk to generate dampness, overstrain internal injury, damp-heat is accumulated to generate phlegm, phlegm is coagulated to lead to blood stasis, damp-heat phlegm stasis cannot be dispersed in time, stagnation is accumulated between skin striae and skin to form cold-damp obstruction inside, and damp-heat phlegm stasis blocks outside, so that qi and blood of joint channels are blocked to cause gout, and therefore, the gout treatment method cannot be a single mode of cold and heat transformation, and a cold-heat concurrent treatment mode is adopted.
Aiming at different pathogenesis of gout, chemical medicines are difficult to treat from multiple aspects, and a multi-component multi-target multi-action mode of the traditional Chinese medicine compound composition provides a good prospect for treating gout.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for treating gout and a preparation method and application thereof according to the theory of traditional Chinese medicine aiming at the defects of the prior art, and the traditional Chinese medicine composition is used for resisting inflammation and relieving pain during acute attack of gout and reducing the level of hematuria.
The invention achieves the aim through the following technical scheme, and the traditional Chinese medicine composition for treating gout comprises the following components in parts by weight: 6-12 parts of angelica sinensis, 3-10 parts of ligusticum wallichii, 15-30 parts of Chinese violet, 15-30 parts of dandelion, 3-9 parts of corydalis amabilis, 5-12 parts of achyranthes bidentata, 10-15 parts of desmodium, 3-10 parts of notopterygium root, 3-10 parts of myrobalan and 1-3 parts of catechu.
The traditional Chinese medicine composition for treating acute gout attack comprises multiple traditional Chinese medicine components such as angelica sinensis, ligusticum wallichii, Chinese violet, dandelion, corydalis amabilis, achyranthes bidentata, desmodium, notopterygium root, myrobalan, catechu and the like. The dandelion-flavor glycosides are cold in nature, enter liver and stomach meridians, and have the effects of clearing away heat and toxic materials, relieving swelling and dissipating stagnation; viola Yedoensis Makino is bitter, pungent and cold in flavor, has the effects of clearing away heat and toxic materials, cooling blood and relieving swelling, and is used as a monarch drug together with dandelion. The lysimachia christinae hance has the effects of promoting diuresis and removing jaundice, promoting diuresis and treating stranguria, and detoxifying and reducing swelling; rhizoma corydalis Decumbentis has effects of promoting blood circulation, dredging collaterals, activating qi-flowing, relieving pain, dispelling pathogenic wind and removing dampness; notopterygii rhizoma has effects of relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, removing dampness, and relieving pain; achyranthes root, radix achyranthis bidentatae removes stasis and promotes menstruation, tonifies liver and kidney, strengthens muscles and bones, induces diuresis and treats stranguria, and draws blood downward; the four medicines are combined to strengthen the effects of the monarch medicine of dissipating blood stasis and relieving pain, dispelling wind and eliminating dampness and easing joint movement, and are used as ministerial medicines together. Angelica sinensis can enrich blood, promote blood circulation and relieve pain; the rhizoma ligustici wallichii is capable of activating blood and qi, dispelling wind and relieving pain; myrobalan fruit has the effects of relieving diarrhea with astringents and reducing pathogenic fire; catechu has effects of promoting blood circulation, relieving pain, stopping bleeding, promoting granulation, eliminating dampness, and healing sore; the four herbs are used together as adjuvant drugs to warm meridians, activate blood circulation, and remove cold. The traditional Chinese medicine composition has the effects of combining the medicines, warming and cooling, treating cold and heat simultaneously, promoting blood circulation to remove blood stasis, removing dampness and relieving pain simultaneously, and achieving the effects of dispelling wind and removing dampness, and relieving swelling and pain together.
Preferably, the traditional Chinese medicine composition comprises the following components in parts by weight: 7-10 parts of angelica sinensis, 4-8 parts of ligusticum wallichii, 17-25 parts of Chinese violet, 17-25 parts of dandelion, 4-7 parts of corydalis amabilis, 7-10 parts of achyranthes bidentata, 11-14 parts of desmodium, 4-8 parts of notopterygium root, 4-8 parts of myrobalan and 1-3 parts of catechu.
Preferably, the traditional Chinese medicine composition comprises the following components in parts by weight: 8 parts of angelica sinensis, 6 parts of ligusticum wallichii, 22 parts of Chinese violet, 22 parts of dandelion, 6 parts of corydalis amabilis, 8 parts of achyranthes bidentata, 12 parts of desmodium, 6 parts of notopterygium root, 6 parts of myrobalan and 2 parts of catechu.
Preferably, the traditional Chinese medicine composition comprises the following components in parts by weight: 12 parts of angelica sinensis, 10 parts of ligusticum wallichii, 30 parts of Chinese violet, 30 parts of dandelion, 9 parts of corydalis amabilis, 12 parts of achyranthes bidentata, 15 parts of desmodium, 10 parts of notopterygium root, 10 parts of myrobalan and 3 parts of catechu.
The invention also provides a preparation method of the traditional Chinese medicine composition for treating gout, which comprises the following steps:
(1) mixing and crushing the angelica, the ligusticum wallichii, the Chinese violet, the dandelion, the corydalis amabilis, the achyranthes bidentata, the desmodium, the notopterygium root, the myrobalan and the catechu in parts by weight into coarse powder, and putting the coarse powder into extraction equipment;
(2) adding an extraction solvent in an amount which is 4-15 times the weight of the traditional Chinese medicinal materials in the step (1), heating and refluxing for extraction for 1-4 times, wherein each time lasts for 1-6 hours, combining the extracting solutions and filtering;
(3) concentrating the extract under reduced pressure to obtain soft extract, drying, and pulverizing to obtain extract powder.
Preferably, the extraction solvent in the step (2) is water or 50-90% aqueous ethanol.
Preferably, the reduced pressure concentration temperature in the step (3) is 50-70 ℃, the drying method is vacuum reduced pressure drying or spray drying, and the extracting solution is concentrated into thick paste with the density of 1.25-1.40 at 60 ℃.
The invention also provides application of the traditional Chinese medicine composition for treating gout, and medicinal auxiliary granules are added into the traditional Chinese medicine composition to prepare a medicinal preparation for treating acute gout.
Preferably, the pharmaceutical co-granules comprise fillers, disintegrants, plasticizers, flavouring agents, lubricants, binders and absorption enhancers.
Preferably, the dosage form of the pharmaceutical preparation comprises granules, tablets, capsules, granules or oral liquid preparations.
The invention has the beneficial effects that:
(1) the traditional Chinese medicine composition provided by the invention can relieve red swelling and hot pain in the acute attack stage of gout, reduce the blood uric acid level, effectively control the recurrence of gout and reduce the occurrence probability of other complications;
(2) the traditional Chinese medicine composition for treating acute gout attack is simple in preparation process, can be prepared into different dosage forms of medicaments for treating acute gout attack after different auxiliary materials are added, and has important significance for treating acute gout attack.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
The embodiment provides a traditional Chinese medicine composition for treating gout, which comprises the following components in parts by weight: 8 parts of angelica sinensis, 6 parts of ligusticum wallichii, 22 parts of Chinese violet, 22 parts of dandelion, 6 parts of corydalis amabilis, 8 parts of achyranthes bidentata, 12 parts of desmodium, 6 parts of notopterygium root, 6 parts of myrobalan and 2 parts of catechu.
The traditional Chinese medicine composition is prepared by adopting the following method:
(1) mixing and crushing the traditional Chinese medicine components into coarse powder, and putting the coarse powder into extraction equipment;
(2) sequentially adding 10, 8 and 6 times of water, heating and refluxing for three times, wherein each time lasts for 1.5 hours, combining extracting solutions, filtering, concentrating under reduced pressure at 60 ℃ to obtain a fluid extract with the relative density of 1.35, drying under reduced pressure at 65 ℃ in vacuum, and crushing to obtain extract powder, thus obtaining the traditional Chinese medicine composition.
Example 2
The embodiment provides a traditional Chinese medicine composition for treating gout, which comprises the following components in parts by weight: 12 parts of angelica sinensis, 10 parts of ligusticum wallichii, 30 parts of Chinese violet, 30 parts of dandelion, 9 parts of corydalis amabilis, 12 parts of achyranthes bidentata, 15 parts of desmodium, 10 parts of notopterygium root, 10 parts of myrobalan and 3 parts of catechu.
The traditional Chinese medicine composition is prepared by adopting the following method:
(1) mixing and crushing the traditional Chinese medicine components into coarse powder, and putting the coarse powder into an extraction container;
(2) sequentially adding 10, 8 and 6 times of 50% ethanol solution, heating and refluxing for extraction for three times, each time for 2.0 hours, combining the extracting solutions, filtering, concentrating under reduced pressure at 60 ℃ to obtain a fluid extract with the relative density of 1.35, drying under reduced pressure at 65 ℃ in vacuum, and crushing to obtain extract powder, thus obtaining the traditional Chinese medicine composition.
Example 3
The embodiment provides a traditional Chinese medicine composition for treating gout, which comprises the following components in parts by weight: 6 parts of angelica sinensis, 3 parts of ligusticum wallichii, 15 parts of Chinese violet, 15 parts of dandelion, 3 parts of corydalis amabilis, 5 parts of achyranthes bidentata, 10 parts of desmodium, 3 parts of notopterygium root, 3 parts of myrobalan and 1 part of catechu.
The traditional Chinese medicine composition is prepared by adopting the following method:
(1) mixing and crushing the traditional Chinese medicine components into coarse powder, and putting the coarse powder into an extraction container;
(2) sequentially adding 10, 8 and 6 times of water, heating and refluxing for three times, each time for 1.5 hours, combining extracting solutions, filtering, concentrating under reduced pressure at 60 ℃ to obtain a fluid extract with the relative density of 1.25, drying under reduced pressure at 65 ℃, crushing to obtain extract powder, and mixing the extract powder with the following raw materials in a proportion of 1: 1 (extract powder: dextrin), adding dextrin, using 85% ethanol solution as adhesive, granulating, drying, and grading to obtain the Chinese medicinal composition granule.
Example 4
The embodiment provides a traditional Chinese medicine composition for treating gout, which comprises the following components in parts by weight: 12 parts of angelica sinensis, 10 parts of ligusticum wallichii, 30 parts of Chinese violet, 30 parts of dandelion, 9 parts of corydalis amabilis, 12 parts of achyranthes bidentata, 15 parts of desmodium, 10 parts of notopterygium root, 10 parts of myrobalan and 3 parts of catechu.
The traditional Chinese medicine composition is prepared by adopting the following method:
(1) mixing and crushing the traditional Chinese medicine components into coarse powder, and putting the coarse powder into an extraction container;
(2) sequentially adding 10, 8 and 6 times of water, heating and refluxing for three times, wherein each time lasts for 1.5 hours, combining extracting solutions, filtering, concentrating under reduced pressure at 60 ℃ to obtain a fluid extract with the relative density of 1.40, drying under reduced pressure at 65 ℃ in vacuum, crushing to obtain extract powder, and adding 15g of starch, 5g of sodium carboxymethyl starch, 1.5g of magnesium stearate and 10g of microcrystalline cellulose. After being mixed evenly, the mixture is filled into capsules to obtain the traditional Chinese medicine composition capsules.
Pharmacodynamic experiment
The analgesic, anti-inflammatory and uric acid-reducing effects of the traditional Chinese medicine composition are examined by adopting potassium oxonate-induced mouse hyperuricemia experiments, xylene-induced mouse ear swelling experiments and acetic acid-induced mouse writhing experiments.
1 method of experiment
1.1 uric acid reduction experiment: 70 mice are randomly divided into three dose groups of a normal group, a model group, a gout relieving group, an allopurinol group and a gout composition, each group comprises 10 mice, the normal group and the model group are filled with normal saline with the same volume as the gastric lavage, the other administration groups are administered with corresponding liquid medicine, 20ml/kg of the liquid medicine is administered once every morning for 5 days continuously, 600mg/kg of oteracil potassium is adopted for intraperitoneal injection molding before the last administration for 1h, 0.5% cmc-Na is injected into the normal group, 0.5ml of orbital vein is collected after the administration for 1h, the room temperature is kept still for 1h, 3500rmp centrifugation is carried out for 10min, supernatant is taken, and the phosphotungstic acid method is adopted to detect the serum uric acid level.
1.2 xylene-induced ear swelling experiments in mice (anti-inflammatory): the 60 mice are randomly divided into three dose groups of a model group, a gout easing group, a compound acetylsalicylic acid group and a gout composition, wherein each group comprises 10 mice, the normal group and the model group are filled with physiological saline with the same volume as the stomach, the other administration groups are administered with corresponding liquid medicine of 20ml/kg, the administration is carried out once in the morning every day for 3 days continuously, and the gout easing group and the compound acetylsalicylic acid are administered once in the last day. 1h after the last administration, 50 mul of xylene is used for smearing the right ear of the mouse, the animal is killed after 1h, the left ear and the right ear are cut off, the ear piece is punched along the pinna of the mouse by a puncher with the aperture of 6mm, the weight is weighed, and the swelling degree of the ear (= the weight of the right ear-the weight of the left ear) is calculated.
1.3 acetic acid induced writhing test (analgesia) in mice: the 60 mice are randomly divided into three dose groups of a model group, a gout easing group, a compound acetylsalicylic acid group and a gout composition, 10 mice are in each group, the normal group and the model group are filled with physiological saline with the same volume as the stomach, the other administration groups are administered with corresponding liquid medicine of 20ml/kg, the administration is carried out once in the morning every day for 3 days continuously, and the compound acetylsalicylic acid is administered once in the last day. Animals are fasted for 12h before the last day of administration, and are injected intraperitoneally with 0.2ml of 0.85% glacial acetic acid solution 1h after the last administration to cause animal writhing, and the writhing number of the animals within 20min after acetic acid is injected intraperitoneally is calculated.
2 results of the experiment
2.1 the effect of the gout composition on reducing uric acid: after modeling, the animal blood uric acid in the model group is obviously increased compared with that in the normal group, which shows that the hyperuricemia model is successfully established, the gout composition with high dose and allopurinol in the administration group can obviously reduce the blood uric acid level of the animal, and the commercially available medicine gout relieving tablet has no obvious influence on the blood uric acid level of the animal (the result is detailed in table 1);
2.2 anti-inflammatory action of gout composition: the gout composition can obviously reduce the swelling degree of the mouse ear caused by dimethylbenzene in high and medium dosage, and the marketed drug gout easing tablet has no obvious influence on the swelling degree of the ear (the result is detailed in table 2);
2.3 analgesic action of gout composition: the gout composition can obviously reduce the writhing number of mice caused by acetic acid at high dose, and also has a reduction trend at medium and low dose, while the writhing number of animals of the commercial medicine gout tablet is equivalent to that of a model (the result is detailed in a table 3).
The invention has the beneficial effects that: the traditional Chinese medicine composition provided by the invention can relieve red swelling and hot pain in the acute attack stage of gout, reduce the blood uric acid level, effectively control the recurrence of gout and reduce the occurrence probability of other complications.
Finally, it should be noted that the above-mentioned embodiments are only preferred embodiments of the present invention, and not intended to limit the present invention, and although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications and equivalents can be made in the technical solutions described in the foregoing embodiments, or some technical features thereof can be replaced. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. A traditional Chinese medicine composition for treating gout is characterized in that: the traditional Chinese medicine composition comprises the following components in parts by weight: 6-12 parts of angelica sinensis, 3-10 parts of ligusticum wallichii, 15-30 parts of Chinese violet, 15-30 parts of dandelion, 3-9 parts of corydalis amabilis, 5-12 parts of achyranthes bidentata, 10-15 parts of desmodium, 3-10 parts of notopterygium root, 3-10 parts of myrobalan and 1-3 parts of catechu.
2. The traditional Chinese medicine composition for treating gout according to claim 1, wherein: the traditional Chinese medicine composition comprises the following components in parts by weight: 7-10 parts of angelica sinensis, 4-8 parts of ligusticum wallichii, 17-25 parts of Chinese violet, 17-25 parts of dandelion, 4-7 parts of corydalis amabilis, 7-10 parts of achyranthes bidentata, 11-14 parts of desmodium, 4-8 parts of notopterygium root, 4-8 parts of myrobalan and 1-3 parts of catechu.
3. The traditional Chinese medicine composition for treating gout according to claim 1, wherein: the traditional Chinese medicine composition comprises the following components in parts by weight: 8 parts of angelica sinensis, 6 parts of ligusticum wallichii, 22 parts of Chinese violet, 22 parts of dandelion, 6 parts of corydalis amabilis, 8 parts of achyranthes bidentata, 12 parts of desmodium, 6 parts of notopterygium root, 6 parts of myrobalan and 2 parts of catechu.
4. The traditional Chinese medicine composition for treating gout according to claim 1, wherein: the traditional Chinese medicine composition comprises the following components in parts by weight: 12 parts of angelica sinensis, 10 parts of ligusticum wallichii, 30 parts of Chinese violet, 30 parts of dandelion, 9 parts of corydalis amabilis, 12 parts of achyranthes bidentata, 15 parts of desmodium, 10 parts of notopterygium root, 10 parts of myrobalan and 3 parts of catechu.
5. The preparation method of the traditional Chinese medicine composition for treating gout according to any one of claims 1 to 4, characterized by comprising the following steps: the method comprises the following steps:
(1) mixing and crushing the angelica, the ligusticum wallichii, the Chinese violet, the dandelion, the corydalis amabilis, the achyranthes bidentata, the desmodium, the notopterygium root, the myrobalan and the catechu in parts by weight into coarse powder, and putting the coarse powder into extraction equipment;
(2) adding an extraction solvent in an amount which is 4-15 times the weight of the traditional Chinese medicinal materials in the step (1), heating and refluxing for extraction for 1-4 times, wherein each time lasts for 1-6 hours, combining the extracting solutions and filtering;
(3) concentrating the extract under reduced pressure to obtain soft extract, drying, and pulverizing to obtain extract powder.
6. The preparation method of the traditional Chinese medicine composition for treating gout according to claim 5, wherein the preparation method comprises the following steps: the extraction solvent in the step (2) is water or 50-90% ethanol water solution.
7. The preparation method of the traditional Chinese medicine composition for treating gout according to claim 5, wherein the preparation method comprises the following steps: the reduced pressure concentration temperature in the step (3) is 50-70 ℃, the drying method is vacuum reduced pressure drying or spray drying, and the extracting solution is concentrated into thick paste with the density of 1.25-1.40 at 60 ℃.
8. The use of a Chinese medicinal composition for the treatment of gout according to any one of claims 1 to 4, wherein: adding medicinal auxiliary granules into the traditional Chinese medicine composition to prepare a medicinal preparation for treating acute gout attack.
9. The use of a traditional Chinese medicine composition for treating gout according to claim 8, wherein: the medicinal auxiliary granule comprises a filler, a disintegrating agent, a plasticizer, a flavoring agent, a lubricant, an adhesive and an absorption enhancer.
10. The use of a traditional Chinese medicine composition for treating gout according to claim 8, wherein: the dosage form of the pharmaceutical preparation comprises granules, tablets, capsules, medicinal granules or oral liquid preparations.
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