CN111759720A

CN111759720A - Disposable nasal cleaning administration device

Info

Publication number: CN111759720A
Application number: CN202010646270.5A
Authority: CN
Inventors: 马宇
Original assignee: Shanghai Changhai Hospital
Current assignee: Shanghai Changhai Hospital
Priority date: 2020-07-07
Filing date: 2020-07-07
Publication date: 2020-10-13
Anticipated expiration: 2040-07-07
Also published as: CN111759720B

Abstract

The invention provides a disposable nasal cleaning drug delivery device, which comprises a conical body, a drug delivery device and a drug delivery device, wherein the interior of the conical body is hollow, the top end of the conical body is opened, and at least one notch guide groove is formed in the lower end part of the side wall; one end of the cleaning conduit is arranged at the opening at the top end of the conical body, and the other end of the cleaning conduit extends out of the bottom end of the conical body and is provided with an injector interface; one end of the spray administration catheter is arranged at the center of the top opening of the conical body, and the other end of the spray administration catheter extends out of the bottom end of the conical body and is provided with a spray guide interface. In rescue sites such as disasters, war wounds and first-aid, the nasal cavity cleaning device can safely realize the consistency action of nasal cavity cleaning and nasal administration, can directly administer analgesic and sedative drugs through the spray administration catheter after cleaning the nasal mucosa once, effectively avoids the influence of foreign matters such as dust attached to the surface of the nasal mucosa on drug attachment and absorption, has more reliable administration effect, does not need complex dangerous steps such as disinfection and searching for venous vessels, and is more practical and feasible in rescue places outside hospitals.

Description

Disposable nasal cleaning administration device

Technical Field

The invention belongs to the technical field of nose emergency medical care instruments, and particularly relates to a disposable nasal cleaning and drug delivery device for emergency treatment and war wound site emergency treatment.

Background

The problems of the wounded on site pain and stress anxiety can not be treated at the first time, the caused serious problems such as the post-treatment mental traumatic stress syndrome and the like are increasingly highlighted, and the serious traumatic stress syndrome even accompanies the whole life of the wounded body after recovery, which is a problem faced by the current first aid. At present, with the development of medical first-aid and war wound treatment technologies, the success rate of treatment is continuously improved, and meanwhile, several safe and non-addiction analgesic and sedative drugs come out and enter clinical practice to obtain satisfactory curative effects. However, these drugs are required to be injected intravenously under the medical aseptic conditions in hospitals to take effect safely as soon as possible, and it is difficult and dangerous to open veins and leave intravenous needles in emergency sites such as battlefields and disaster severe environments, which is an important reason why many safe and effective pain-relieving and calming drugs for preventing and treating mental trauma of wounded cannot be used as early as possible at present.

The nasal cavity is an important ventilation organ of the human body, and the anatomical structure mainly comprises vestibule and inherent nasal cavity. The nasal cavity is internally provided with important anatomical structures such as an olfactory region, an upper middle turbinate, a lower turbinate and the like, mucous membranes are attached to the surfaces of the important anatomical structures, ciliated epithelium secretion mucus is attached to the surfaces of the mucous membranes, and the secretion mucus flows from the front to the rear and lower oropharyngeal parts slowly and dynamically, so that the aims of adsorbing dust and moistening and warming inhalation air are fulfilled. There are abundant capillary networks and olfactory nerve cells under the mucosa that can be directly connected to the center. The characteristics of the nasal anatomy structure enable the drugs of analgesia, sedation and the like to be directly contacted with the nasal mucosa through nasal administration and permeate into the central nerve and capillary network to take effect rapidly, thereby avoiding the complex dangerous process of intravenous injection.

At present, the dosage forms for nasal administration for systemic administration mainly include spray dosage forms, instilled liquid and gel dosage forms. The mechanism acting on the whole body is that liquid medicine at the nasal vestibule position is sprayed or dripped to mucous membrane surfaces of nasal concha, olfactory region and other parts for adhesion, and then is uniformly distributed along with slow flow of mucous in the oropharynx direction and permeates into internal environments such as nerve vessels and the like under the nasal concha mucous membrane to play the drug effect. In recent years, many patents are designed for nasal administration, and manufacturers at home and abroad produce many products such as sprays and drops for nasal administration, such as patents, and for example, patent nos. CN107995873A and CN110448553A disclose a spray dispenser for nasal administration and a method for preparing drops, respectively.

However, the current analgesic products and medicaments administered nasally are not suitable for emergency treatment and use in the field of war wounds, mainly for the following reasons:

1. at present, all products are designed by integrating a medicine storage bottle and an atomizing spray head and are disposable, one bottle can only be used by one patient repeatedly, and each wounded person in a large number of wounded persons in an emergency site only needs to be used once, so that the integrated design and use can cause high cost and waste or can not meet the site dosage.

2. At present, most of products spray high-concentration liquid medicine to the surface of nasal mucosa in a spray form and then permeate into nervous system and capillaries to play a role, but the products aim at patients with clean nasal cavities at ordinary times. And a large amount of dust and other substances are inevitably attached to the nasal mucosa surface of the wounded in the disaster and battlefield knock site, so that the attachment and the permeation of the medicine into the internal environment of the body to play a role are greatly influenced, the effect is weakened, the onset time of the medicine is delayed, and the difficulty of site treatment is increased.

Disclosure of Invention

The invention aims to solve the problems and provides a disposable nasal cleaning and administration device which can be plugged into a mucous membrane area facing an inherent nasal cavity at an opening of a nasal vestibule, the nasal mucosa is cleaned by normal saline through an outer tube, and then an atomizing agent of medicines for easing pain and calming and the like is sprayed out through a built-in spraying tube core after the dust on the surface of the nasal mucosa is cleaned by normal saline, and the atomizing agent is attached to the cleaned surface of the nasal mucosa and then takes effect rapidly. The medicine storage device can be filled with multiple persons and can be connected with a plurality of disposable intranasal cleaning and administration devices in the invention, thereby achieving the purposes of saving and bringing convenience for emergency personnel to carry. In order to achieve the purpose, the invention provides the following technical scheme:

< Structure I >

The disposable nasal cleaning drug delivery device provided by the invention has the following technical characteristics: comprises a conical body, the interior of the conical body is hollow, the top end of the conical body is opened, and the lower end part of the side wall is provided with at least one notch guide groove; one end of the cleaning conduit is arranged at the opening at the top end of the conical body, and the other end of the cleaning conduit extends out of the bottom end of the conical body and is provided with an injector interface; one end of the spray administration catheter is arranged at the center of the top opening of the conical body, and the other end of the spray administration catheter extends out of the bottom end of the conical body and is provided with a spray guide interface. Wherein the inner diameter of the cleaning catheter is 2-3 times of the inner diameter of the spray administration catheter.

In the invention, the shape of the conical body is matched with the internal structure of the nasal vestibule, and the conical body can be directly placed into the nasal vestibule, and the opening end of the conical body is opposite to the front part of the turbinate area of the inherent nasal cavity area.

Further, in the disposable nasal wash drug delivery device provided by the present invention, the top end portion of the tapered body is provided with scale marks for indicating the depth of insertion of the tapered body into the nasal cavity. The two notch guide grooves are symmetrically arranged on the conical body respectively, the length of each notch guide groove is 2/3-3/4 of the length of a bus of the conical body, and the radian is 20-30 degrees. When the top end part of the conical body is inserted into the nasal cavity, the top end part of the notch guide groove also extends into the nasal cavity, and the drainage of cleaning liquid in the nasal cavity is realized.

Further, in the disposable nasal cleaning and drug delivery device provided by the invention, the length of the conical body is 5-7 cm, the inner diameter of the cleaning catheter is 2-2.5 mm, and the inner diameter of the spray drug delivery catheter is 1 mm.

Furthermore, in the disposable transnasal cleaning and administration device provided by the invention, the cleaning joint and the administration joint are concentrically arranged at the opening at the top end of the conical body, the cleaning joint is positioned at the center of the opening at the top end, and the administration joint is positioned at the periphery of the cleaning joint and is fixedly connected with the cleaning joint through a plurality of connecting rods.

Furthermore, in the disposable transnasal cleaning administration device provided by the invention, the cleaning joint is S-shaped, the head end part is parallel to the administration joint, the middle bending part is provided with a through hole for the spray administration catheter to pass through in a sealing way, and the tail end part is connected with the cleaning catheter in a sealing way. The S-shaped design and the design that the administration catheter penetrates through the cleaning head in a sealing mode are both used for limiting the pressure sprayed by the cleaning liquid during buffering pushing and injecting cleaning, and the too high water flow impact injection pressure can be buffered, so that the nasal mucosa is prevented from being damaged, and the nasal mucosa is prevented from being damaged by the high-pressure cleaning liquid caused by the fact that operators in emergency sites are nervous and excessively exert force.

Further, in the disposable nasal cleaning administration device provided by the invention, the cleaning catheter and the spray administration catheter are integrally formed; the outer diameter of the cleaning conduit is the same as the inner diameter of the top opening of the conical body and is directly arranged in the top opening; the head end part of the spray administration catheter passes through the cleaning catheter in a sealing way and is connected with the cleaning catheter through an annular connector.

Furthermore, in the disposable transnasal cleaning and administration device provided by the invention, the side end of the bottom surface of the conical body is provided with a cleaning catheter clamping groove, and the spray administration catheter extends out from the middle part of the conical body. The injector interface is conical, and the spray guide interface is hollow cylindrical.

Furthermore, in the disposable nasal cleaning and administration device provided by the invention, the conical body is made of silica gel or rubber, so that the device can be inserted into the nasal vestibule of the wounded without damage.

< Structure two >

Further, the invention also provides a disposable nasal cleaning administration kit, which has the technical characteristics that: comprising a disposable nasal wash administration device as described in structure one; the opening end of the cleaning fluid drainage bag corresponds to the notch guide groove on the conical body, and a connecting tongue capable of being installed on the notch guide groove is arranged on the cleaning fluid drainage bag. Preferably, the connecting tongue is mounted on the inner side surface of the protrusion of the recess guide groove, and the adhesive is disposed thereon.

The cleaning solution drainage bag is used for containing cleaning solution for the nasal cavity. Before cleaning the nasal cavity, the opening end is sleeved on the bottom end part of the notch guide groove, and the position is fixed by the adhesive on the connecting tongue. In the invention, limited by application occasions, the cleaning solution drainage bag is unnecessary, because in emergency situations such as first aid, disasters and battlefield knock sites, the condition that the clothes of the wounded are polluted by the cleaning solution does not need to be considered, and the nasal cavity cleaning solution can directly flow out through the notch guide groove. However, when the device of the invention is used for clinically treating nasal cavity diseases, such as local application in nasal cavity, operation cleaning and disinfection and the like, the cleaning solution drainage bag is required to be applied, so that the clothes of a patient are prevented from being polluted.

Action and Effect of the invention

The disposable nasal cleaning drug delivery device provided by the invention has the following technical effects:

firstly, in rescue sites such as disasters, war injury first-aid and the like, the device can realize the consistency action of nasal cavity cleaning and nasal administration, the nasal mucosa can be cleaned once through the cleaning catheter, and then the pain-relieving and calming medicine can be directly administered through the spray administration catheter through the nose, so that the influence of foreign matters such as dust attached to the surface of the nasal mucosa on the attachment and absorption of the medicine is effectively avoided, the administration effect is more reliable, complex dangerous steps such as disinfection and searching of vein and the like are not needed, and the device is more practical and feasible in rescue places outside hospitals.

Secondly, wash pipe and spraying pipe of dosing and be provided with injection interface and spraying guide interface respectively, can satisfy all intranasal modes of dosing simultaneously, the blank that does not satisfy multiple route of dosing products such as spraying, injection drip and spill and paint simultaneously on having remedied at present market, when salvaging, the professional only needs to take a bottle of large capacity liquid medicine just can rescue multiple wounded simultaneously, practice thrift treatment cost and conveniently carry, the storage medicine and the shower nozzle integrated design of dosing of mainstream on having overcome the market at present, the use object is that single patient oneself is fixed, use expensive and be unfavorable for the defect that the large batch wounded of scene rescue used.

Thirdly, the invention is not only used for the purpose of general medication such as analgesia, sedation and the like, but also can meet the requirements of local medication in nasal cavity, operation cleaning and disinfection and the like when a clinical specialist is used for treating nasal diseases due to the design of the spraying and injection interface and the drainage notch.

Drawings

FIG. 1 is a schematic diagram of the external structure of a disposable nasal wash administration set according to a first embodiment of the present invention;

FIG. 2 is a schematic cross-sectional view of a disposable nasal wash delivery device in accordance with a first embodiment of the present invention;

FIG. 3 is a schematic cross-sectional view of a disposable nasal wash delivery device according to example two of the present invention.

Detailed Description

The present invention will be described in detail below with reference to examples and the accompanying drawings. The following examples should not be construed as limiting the scope of the invention.

Example one

As shown in FIG. 1, the disposable nasal wash administration set 100 in this embodiment includes a disposable nasal wash administration device 10 and a disposable wash drain bag 20 that can be used therewith.

As shown in FIG. 2, the disposable nasal wash administration device 10 includes a tapered body 11, a wash adapter 12, an administration adapter 13, a wash conduit 14, and a spray administration conduit 15.

The shape of the conical body 11 is matched with the structure in the nasal vestibule, the conical body can be directly placed into the nasal vestibule, the conical body is hollow and has an opening at the top end, the conical body is opposite to the front part of a turbinate area of a natural nasal cavity area, the length of the conical body is 5-7 cm, and the conical body is made of silica gel or rubber, so that the conical body can be plugged into the nasal vestibule of a wounded person without damage. Two notch guide grooves 111 are symmetrically arranged on the lower end part of the side wall of the conical body 11, and the upper end part is provided with a scale mark 112 for indicating the depth of the conical body inserted into the nasal cavity. The length of each notch guide groove 111 is 2/3-3/4 of the length of a generatrix of the conical body, the radian is 20-30 degrees, and after the top end part of the conical body is inserted into the nasal cavity, the top end part of each notch guide groove also extends into the nasal cavity, so that the drainage of cleaning liquid in the nasal cavity is realized.

Wash and connect 12 and dose 13 and connect the concentric setting at toper body top opening part, wash and connect 12 and be located top opening center, dose and connect 13 and be located and wash and connect the periphery, connect 12 fixed connection through many connecting rods 16 and washing.

The cleaning conduit 14 and the spray administration conduit 15 are fixedly mounted at the head ends thereof on the cleaning joint 12 and the administration joint 13, respectively, and the tail ends thereof extend out from the bottom of the tapered body 11. The tail end of the cleaning catheter 14 is provided with an injector interface 141 which can be connected with an injector containing normal saline for washing the nasal cavity, and the water for washing is injected into the nasal cavity for washing; the tail end of the spray administration catheter 15 is provided with a spray guide interface 151 which is hermetically connected with the spray type medicine storage device and used for guiding the spray liquid medicine to enter the nasal cavity. In this embodiment, the syringe port 141 is in the form of a bell mouth, the spray guide port 151 is in the form of a hollow cylinder, and a seal ring is provided therein and can be sealingly connected to the administration head of the spray administration device.

In the embodiment, the inner diameter of the cleaning catheter is 2-3 mm, and the inner diameter of the spray administration catheter is 1 mm. In order to achieve a clear distinction between the cleaning conduit 14 and the aerosol administration conduit 15, the cleaning conduit 14 extends from the side end of the conical body 11, and the aerosol administration conduit 15 extends from a middle position of the conical body 11.

In order to achieve the above object, in this embodiment, the cleaning joint 12 is S-shaped, the head end portion is parallel to the administration joint 13, the middle bent portion is provided with a through hole for the spray administration tube 15 to pass through, and the tail end portion is connected to the head end of the cleaning tube 14 in a sealing manner. The tail end part of the cleaning conduit 14 is fixedly arranged on the conical body 11 through a clamping groove at the bottom end of the conical body 11 or through an adhesion mode.

The disposable nasal cavity cleaning and drug delivery device 10 can be designed for people with different models and different nasal cavity sizes, and is used for disaster, war wound first aid and other field use principles as follows:

after a professional medical first-aid worker inserts the top end of the conical body 11 into the nasal vestibule of the wounded to a proper depth, and a patient does not have obvious discomfort, the injector with pumped physiological saline is connected with the injector interface 141 at the tail end of the cleaning conduit 14, a small amount of physiological saline is slowly and gently injected, and after the physiological saline flows out from the opening at the top end, dust and the like on the surfaces of mucous membrane areas at positions such as a sniffing area and an upper turbinate and the like are cleaned and flow out along the notch guide groove 111 on the conical body 11, so that the color judgment of the cleaning liquid and the pollution or damage condition in the nasal cavity can be observed conveniently; after repeated cleaning is carried out for a plurality of times to confirm that the medicine is completely allowed to be administered, a liquid medicine outlet on the medicine storage bottle of the sprayed medicine is connected with the spray guide interface 2, the spraying device is triggered by pressing down for one time, then the air in the pipeline is discharged, the spraying device is quickly pressed down for the second time, the medicine with the preset dosage is accurately sprayed onto the surfaces of the sniffing area and the turbinate area, along with the flowing of mucus on the clean mucous membrane surface, the liquid medicine is uniformly distributed on the mucous membrane surface of the inherent nasal cavity, and permeates nerves and capillary blood vessels below the mucous membrane surface within about 10 minutes to play the drug effect.

After pressing the spraying, the spraying liquid medicine can get into spraying pipe 15 of dosing under the high pressure effect, spraying pipe 15 pipe diameter is fine can guarantee that the spraying liquid medicine flows to the top of toper body at a high speed under the pressure effect and goes out the medicine mouth department, the velocity of flow difference of a small amount of liquid medicine and surrounding air after spouting of medicine mouth department at a high speed has caused pressure imbalance, the liquid medicine is dispersed rapidly into the mist medicine liquid drop evenly distributed to apart from the nasal vestibule nearer on the inherent nasal cavity, in, mucous membrane surfaces such as inferior turbinate and smelling the district, and along with turbinate mucociliary motion rapidly evenly distributed to whole mucous membrane surface and permeate the submucosal capillary and nerve simultaneously play the pharmacodynamics.

According to the professional scientific research, the whole body analgesic effect reaches the peak value about 15 minutes after the healthy adults spray 0.1 ml of the analgesic drug. Because part of the liquid medicine directly enters the center through nerve cells under the mucous membrane, the blood brain barrier step which is necessary for intravenous administration is avoided to directly play a role, the administration mode is even faster than the intramuscular and intravenous injection speed for the central analgesic and sedative drug, the fussy steps of disinfection, venipuncture and the like are also avoided, the time is greatly saved, and the application of the liquid medicine by professional medical care personnel in disaster and war wound sites is very facilitated.

According to fig. 1, the cleaning solution drainage bag 20 is transparent and comprises a drainage bag body 21 and a connecting tongue 22. The opening end of the drainage bag body 21 corresponds to the bottom end of the notch guide groove 111, the connecting tongue 22 is arranged on the opening end of the drainage bag body 21, the connecting tongue is arranged on the convex inner side surface of the notch guide groove, and the adhesive 221 is arranged on the connecting tongue.

Therefore, when the product of the invention is packaged, the disposable nasal cleaning and drug administration device 10 can be packaged separately and used for the first aid in the field of disasters and war wounds, and can also be packaged with the cleaning solution drainage bag 20 in a combined way and used for local application in nasal cavities and cleaning and disinfection in operations when the nasal cavity diseases are treated clinically.

Example two

In the second embodiment, the same components as those in the first embodiment are denoted by the same reference numerals, and the same description thereof is omitted.

Referring to fig. 3, this embodiment differs from the first embodiment in the construction of a disposable nasal wash administration set. The disposable nasal wash administration set 30 includes a tapered body 11, a wash conduit 32, and a spray administration conduit 33.

The cleaning conduit 32 and the spray administration conduit 33 are integrally formed; the cleaning catheter 32 has the same outer diameter as the inner diameter of the top end opening of the tapered body and is directly fitted into the top end opening, and the tip end portion of the aerosol administration catheter 33 is sealingly passed through the cleaning catheter. In order to enhance the connection stability between the two pipes, the two pipes are connected through an annular connector.

The tail end of the cleaning catheter 32 is also provided with an injector interface which can be connected with an injector containing normal saline for washing the nasal cavity, and the water for washing is injected into the nasal cavity for washing; the tail end of the spray administration catheter 33 is provided with a spray guide interface which is hermetically connected with the spray type medicine storage device and used for guiding the spray liquid medicine to enter the nasal cavity. The injector interface is also in a horn mouth shape, the spray guide interface is also in a hollow cylinder shape, and a sealing ring is arranged in the injector interface and can be connected with a dosing head of the spray type dosing device in a sealing way.

As in the first embodiment, the cleaning tube 32 extends from the side end of the tapered body 11, and the aerosol delivery tube 33 extends from the middle of the tapered body 11. The tail end of the cleaning conduit 32 is fixedly mounted on the tapered body 11 through a slot at the bottom end of the tapered body 11 or through an adhesive manner.

The device of the invention can also be used for administering non-spray type liquid medicine, and can be directly used for spraying the medicine after being cleaned only by the cleaning catheter.

The foregoing shows and describes the general principles, essential features, and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are given by way of illustration of the principles of the present invention, and that various changes and modifications may be made without departing from the spirit and scope of the invention as defined by the appended claims. The scope of the invention is defined by the appended claims and equivalents thereof.

Claims

1. A disposable nasal wash drug delivery device, comprising:

a tapered body which is hollow inside and open at the top end, and at least one notch guide groove is formed on the lower end part of the side wall;

one end of the cleaning conduit is arranged at the opening at the top end of the conical body, and the other end of the cleaning conduit extends out of the bottom end of the conical body and is provided with an injector interface;

one end of the spray administration catheter is arranged at the center of the opening at the top end of the conical body, the other end of the spray administration catheter extends out of the bottom end of the conical body and is provided with a spray guide interface,

wherein, after the conical body is arranged in the nasal vestibule, the top end opening is just opposite to the front part of the turbinate area of the inherent nasal cavity area,

the inner diameter of the cleaning catheter is 2-3 times of that of the spray administration catheter.

2. A disposable nasal cleaning and drug delivery device according to claim 1, wherein:

wherein the top end part of the conical body is provided with scale marks,

the two notch guide grooves are symmetrically arranged on the conical body respectively, the length of each notch guide groove is 2/3-3/4 of the length of a bus of the conical body, and the radian is 20-30 degrees.

3. A disposable nasal cleaning and drug delivery device according to claim 1, wherein:

wherein, the length of the conical body is 5-7 cm, the inner diameter of the cleaning catheter is 2-2.5 mm, and the inner diameter of the spray administration catheter is 1 mm.

4. A disposable nasal cleaning and drug delivery device according to claim 1, wherein:

the cleaning joint and the dosing joint are concentrically arranged at the opening at the top end of the conical body, the cleaning joint is located at the center of the opening at the top end, and the dosing joint is located at the periphery of the cleaning joint and is fixedly connected with the cleaning joint through a plurality of connecting rods.

5. A disposable nasal cleaning and drug delivery device according to claim 4, wherein:

the cleaning joint is S-shaped, the head end part is parallel to the administration joint, the middle bending part is provided with a through hole for the spray administration catheter to pass through in a sealing way, and the tail end part is connected with the cleaning catheter in a sealing way.

6. A disposable nasal cleaning and drug delivery device according to claim 1, wherein:

wherein the cleaning catheter and the spray administration catheter are integrally formed; the outer diameter of the cleaning conduit is the same as the inner diameter of the top end opening of the conical body, and the cleaning conduit is directly arranged in the top end opening; the head end part of the spray administration catheter penetrates through the cleaning catheter in a sealing manner and is connected with the cleaning catheter through an annular connector.

7. A disposable nasal cleaning and drug delivery device according to claim 1, wherein:

wherein, a cleaning catheter clamping groove is arranged at the bottom side end of the conical body, the spray administration catheter extends out from the middle part of the conical body,

the injector interface is conical, and the spray guide interface is hollow cylindrical.

8. A disposable nasal cleaning and drug delivery device according to claim 1, wherein:

the cone-shaped body is made of silica gel or rubber, and the shape of the cone-shaped body is matched with the internal volume of the vestibule in the nasal cavity.

9. A disposable nasal wash administration kit, comprising:

a disposable nasal wash administration device as claimed in any one of claims 1 to 8;

and the opening end of the cleaning solution drainage bag corresponds to the notch guide groove on the conical body of the disposable transnasal cleaning and drug delivery device, and a connecting tongue capable of being installed on the notch guide groove is arranged on the cleaning solution drainage bag.

10. A disposable nasal wash administration kit according to claim 9, wherein:

wherein, the connecting tongue is arranged on the inner side surface of the protrusion of the notch guide groove, and is provided with adhesive.