CN111658675A

CN111658675A - Composition for treating male sexual function and preparation method thereof

Info

Publication number: CN111658675A
Application number: CN202010547120.9A
Authority: CN
Inventors: 欧阳志华
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-06-16
Filing date: 2020-06-16
Publication date: 2020-09-15

Abstract

The invention relates to a composition for treating male sexual function and a preparation method thereof, wherein the composition comprises the following components: toad venom, a surfactant and a solvent. The external medicine is prepared by the compatibility of the components of toad venom and the like, and can effectively improve the sexual intercourse time of men.

Description

Composition for treating male sexual function and preparation method thereof

Technical Field

The invention relates to the field of medicines, in particular to a composition for treating male sexual function and a preparation method thereof.

Background

The onset of premature ejaculation is related to various factors, mainly related to kidney deficiency, heart and spleen deficiency and liver and gallbladder dryness and coldness. Kidneys store essence and produce sperm, and are closely related to the anterior yin and the posterior yin of human body, called kidneys governing two yin, which store and release the reproductive and growth substances of human body, control the excretion of sexual function of human body, and cause premature ejaculation due to incontinent sperm excretion caused by acquired deficiency or masturbation, excessive sexual life and kidney deficiency sexual dysfunction. Excessive brain or overstrain impairs the spirit, damages the heart and spleen, causes deficiency of qi and blood, causes premature ejaculation due to deficiency of qi and blood, branches of liver meridians pass around the anterior yin, the penis is collected by the pectoral channels, and qi and blood are regulated by the liver, so depression, irritation and anger can cause recklessly movement of liver fire, and lower disturbance of the essence storage center causes semen loss and premature ejaculation. The excessive intake of fat and sweet, alcohol addiction, cold production, or cold exopathic feeling, cold flow, lower energizer, premature ejaculation caused by internal disturbance of the essence chamber, or abnormal liver evacuation due to downward flow of the liver channel, premature ejaculation caused by uncontrollable occlusion, or premature ejaculation caused by fear of kidney injury, unconsolidated semen and premature ejaculation, or unsmooth mood, depression and liver injury, liver loss of the way, also can cause premature ejaculation caused by uncontrolled occlusion.

Disclosure of Invention

One technical problem to be solved by one aspect of the present disclosure is to provide a composition for treating premature ejaculation in a male; the other technical problem to be solved is to provide a preparation method of the composition.

The technical scheme adopted by the invention for solving the technical problems is as follows: a composition for treating male function, the composition consisting of: toad venom, a surfactant and a solvent.

The composition for treating male sexual function comprises the following additional traditional Chinese medicines for tonifying kidney and supporting yang.

The composition for treating male sexual function comprises bacteriostatic agent and sweetener.

The composition for treating male sexual function is characterized in that the solvent is one or both of water and ethanol.

The composition for treating male sexual function comprises one or more of clove, fructus cnidii, raspberry, herba epimedii, cherokee rose fruit, maca, medlar and cistanche.

The composition for treating male sexual function comprises flos Caryophylli, fructus Cnidii, Rubi fructus and herba Epimedii;

the composition comprises, by weight, 0.1-1 part of toad venom, 0.1-2 parts of clove, 0.1-1 part of fructus cnidii, 0.1-1 part of raspberry, 0.1-2 parts of epimedium herb, 0.01-0.5 part of chlorhexidine acetate serving as a bacteriostatic agent, 0.1-1 part of polyoxyethylene sorbitan monooleate serving as a surfactant, 0.1-2 parts of nonylphenol polyoxyethylene ether, 1-8 parts of a sweetening agent, 10-40 parts of ethanol and the balance of water.

The composition for treating male sexual function comprises 0.2 part of toad venom, 0.5 part of clove, 0.3 part of fructus cnidii, 0.1 part of raspberry, 0.5 part of epimedium, 0.05 part of chlorhexidine acetate, 0.5 part of polyoxyethylene sorbitan monooleate, 0.8 part of nonylphenol polyoxyethylene ether, 3 parts of glucose and 1.5 parts of cane sugar as sweetening agents, 25 parts of ethanol and the balance of water.

The composition for treating male sexual function comprises fructus Rosae Laevigatae, maca, fructus Lycii and Cistanchis herba;

the composition comprises, by weight, 0.1-1 part of toad venom, 0.1-1 part of cherokee rose fruit, 0.01-1 part of maca, 0.1-1 part of medlar and 0.01-1 part of cistanche deserticola, 0.01-0.5 part of chlorhexidine acetate serving as a bacteriostatic agent, 0.01-1 part of polyoxyethylene sorbitan monooleate serving as a surfactant, 1-8 parts of a sweetening agent, 10-40 parts of ethanol and the balance of water.

The composition for treating male sexual function comprises 0.2 part of toad venom, 0.5 part of cherokee rose fruit, 0.1 part of maca, 0.5 part of medlar, 0.1 part of cistanche, 0.1 part of polyoxyethylene sorbitan monooleate, 0.1 part of chlorhexidine acetate, 3.5 parts of glucose as a sweetening agent, 2.0 parts of sucrose, 25 parts of ethanol and the balance of water.

A method for preparing a composition for treating male sexual function, comprising the following steps:

decocting venenum Bufonis and the Chinese medicinal materials with water or soaking in ethanol or treating with water and ethanol by ultrasonic low temperature extraction technology, adding surfactant, sweetener and bacteriostatic agent, and making into spray, unguent, liquid, gel or wet towel.

One advantageous effect brought by one aspect of the present disclosure: the composition utilizes the delayed action of Bufonis venenum, is helpful for blood supply of penis, and effectively solves the problem of fatigue caused by prolonged sexual intercourse time.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below. It is to be understood that the embodiments described are only a few embodiments of the present invention, and not all embodiments.

All other embodiments, which can be derived by a person skilled in the art from the described embodiments of the invention without any inventive step, are within the scope of protection of the invention. Unless defined otherwise, technical or scientific terms used herein shall have the ordinary meaning as understood by one of ordinary skill in the art to which this invention belongs.

The invention provides a composition for treating male sexual function, which is an external medicine and can be in the forms of spray, paste, liquid, gel or adhered to wet tissues and the like, and the composition comprises the following components: toad venom, a surfactant and a solvent.

The Bufonis venenum is secretion of late auricular gland and epidermal gland of Bufo siccus, white emulsion or light yellow liquid, and is prepared by extracting Bufonis venenum from Bufonis venenum, drying, coloring, sealing, and storing. Furthermore, the composition can comprise bacteriostatic agents which can inhibit microorganisms; sweetening agent can also be added to improve the mouthfeel of the product. The surfactant can adopt polyoxyethylene sorbitan monooleate and nonylphenol polyoxyethylene ether, but is not limited to the polyoxyethylene sorbitan monooleate and the nonylphenol polyoxyethylene ether; the bacteriostatic agent can adopt chlorhexidine acetate but is not limited to the chlorhexidine acetate; the sweetener can be glucose, sucrose, etc.; the solvent may be one of water and ethanol, or both of them.

The relevant proportioning examples of the composition are as follows:

further, the composition consists of the following components: the composition also comprises additional traditional Chinese medicines for tonifying kidney and supporting yang, and the additional traditional Chinese medicines can effectively strengthen the delayed action of the toad venom, strengthen blood supply and optimize and improve the treatment effect. The additional Chinese medicinal materials include one or more of flos Caryophylli, fructus Cnidii, Rubi fructus, herba Epimedii, fructus Rosae Laevigatae, maca, fructus Lycii and Cistanchis herba.

Specifically, the composition comprises the following effective components in parts by weight:

0.1-1 part of toad venom, 0.01-3 parts of surfactant, 0.01-0.5 part of bacteriostatic agent and 1-8 parts of sweetening agent;

one or more additional traditional Chinese medicines can be selected from the composition, and the corresponding parts by weight are as follows: 0.1-2 parts of clove, 0.1-1 part of common cnidium fruit, 0.1-1 part of raspberry, 0.1-2 parts of epimedium herb, 0.1-1 part of cherokee rose fruit, 0.01-1 part of maca, 0.1-1 part of medlar and 0.01-1 part of desertliving cistanche;

the balance of solvent, 10-40 parts of ethanol in the solvent and the balance of water (full to 100 parts).

In one embodiment, the additional Chinese medicinal materials are: clove, common cnidium fruit, raspberry and epimedium herb.

Clove, named as Chinese medicine, has the pharmacological actions of warming the middle-jiao, lowering the adverse flow of qi, tonifying the kidney and supporting yang. Is the dry bud of Eugenia caryophyllata of Myrtaceae, and is slightly shaped like a pestle with a length of 1-2 cm. The corolla is spherical, the diameter is 0.3-0.5 cm, the petals are 4, the corolla is in a double-tile shape and is wrapped, the corolla is brown or brown yellow, stamens and flower columns are arranged in the petals, and a plurality of yellow fine-grained anthers can be seen after the corolla is rubbed and crushed. The calyx cylinder is cylindrical, slightly flat, slightly bent, 0.7-1.4 cm long, 0.3-0.6 cm in diameter, reddish brown or tan, 4 triangular sepals on the upper part, and is separated in a cross shape, solid, rich in oil, strong in fragrance and smell, spicy and pungent in taste and numb in tongue.

Fructus Cnidii, named as Chinese medicine, is dried mature fruit of cnidium monnieri (L.) DC of Umbelliferae, and has pharmacological effects of warming kidney, tonifying yang, dispelling pathogenic wind, eliminating dampness, and killing parasite. Ben Cao Jing Shu (the book of materia Medica Prime and Dredging): cnidium fruit, fructus Cnidii, is bitter in taste and non-toxic, and is pungent, sweet and sweet in the book of Olympic records. Its smell is always warm and dry, and yang is also the cause. So it can be used for treating female swelling and pain in yin, male impotence, dampness and itching in yin, arthralgia, joint pain and malignant boil. The book of the entry warms the middle-jiao and purges the qi, makes women dirty and hot, makes men have strong yin, makes people feel light after being taken for a long time, and makes people have children. The bitter taste can remove dampness, warm and dispel cold, the pungent taste can moisten kidney, and the sweet taste can benefit spleen, so that the traditional Chinese medicine can remove all diseases caused by deficiency cold-dampness of women and men. Cold-dampness can be removed, so it can treat diseases and tonify yang. "

The raspberry is named as traditional Chinese medicine, is the dry fruit of Rubus chingii of Rosaceae, and has pharmacological effects of nourishing liver and kidney, reducing defecation, tonifying yang, securing essence and improving eyesight. The properties of the medicinal materials are as follows: the polymeric fruit is formed by polymerizing a plurality of drupes, is conical or oblate conical, is 0.6-1.3 cm high, and has a diameter of 0.5-1.2 cm. The surface is yellowish green or light brown, the top end is round, and the center of the base is concave. The persistent calyx is dark brown, and the fruit stem is marked below the persistent calyx. The small fruits are easy to peel off, each small fruit is half-moon-shaped, grey white fuzz is densely covered on the back, the two sides of each small fruit are provided with obvious reticulate patterns, and the abdomen of each small fruit is provided with a protruded ridge line. Light weight and hard mass. Light smell, slightly sour and astringent taste. The herbal medicine Tongxian: rubi fructus, sweet and neutral in nature, acts as a drug to treat impotence, consolidating semen to arrest drowsiness, strengthening kidney without dryness-heat bias, consolidating semen without astringency, also is a herb of jin Yu. "

Herba epimedii, also called herba epimedii, just before, has the functions of tonifying kidney yang, strengthening bones and muscles and dispelling wind-damp according to the record of Chinese pharmacopoeia, lists as a middle-quality product in Shen nong Ben Cao Jing, has the functions of tonifying kidney yang, strengthening bones and muscles and dispelling wind-damp, is used for impotence and spermatorrhea, flaccidity of muscles and bones, rheumatic arthralgia and numbness and contracture caused by kidney yang deficiency, and is a clinical common traditional Chinese medicine.

The weight parts of the components are, for example, 0.1-1 part of toad venom, 0.1-2 parts of clove, 0.1-1 part of common cnidium fruit, 0.1-1 part of raspberry, 0.1-2 parts of epimedium herb, 0.01-0.5 part of chlorhexidine acetate serving as a bacteriostatic agent, 0.01-1 part of polyoxyethylene sorbitan monooleate serving as a surfactant, 0.1-2 parts of nonylphenol polyoxyethylene ether, 1-8 parts of a sweetening agent, 10-40 parts of ethanol and the balance of water (added to 100 parts). Preferably, the composition comprises 0.2 part of toad venom, 0.5 part of clove, 0.3 part of fructus cnidii, 0.1 part of raspberry, 0.5 part of epimedium, 0.05 part of chlorhexidine acetate, 0.5 part of polyoxyethylene sorbitan monooleate, 0.8 part of nonylphenol polyoxyethylene ether, 3 parts of glucose and 1.5 parts of sucrose, 25 parts of ethanol and the balance of water.

In one embodiment, the additional traditional Chinese medicines are: fructus Rosae Laevigatae, maca, fructus Lycii and Cistanchis herba.

Cherokee rose fruit, named as traditional Chinese medicine, is the dried mature fruit of Cherokee rose fruit of Rosaceae, and has the functions of securing essence and reducing urination, and relieving diarrhea with astringents. The characteristics are as follows: the product is a false fruit formed by the growth of receptacle, and is in the shape of inverted egg, with a length of 2-3.5 cm and a diameter of 1-2 cm. The surface is reddish yellow or reddish brown, and has raised brown dots which are residues after burr shedding. The top end has disk calyx residue, the center has yellow column base, and the lower part is tapered. Is hard. After cutting, the wall thickness of the receptacle is 1-2 mm, most hard small fruits are arranged in the receptacle, and the inner wall and the fruits have faint yellow villi. No smell, sweet and slightly astringent taste. Talking on a dream's stream of pens: jin Ying Zi can stop enuresis and purge, it is warm and astringent, and jin Ying Zi is used in the world, when it is red and cooked, it is decocted to get juice and paste, even if it is red, it is sweet in taste, and it is completely broken and astringent in taste. It is collected when half yellow is collected and dried and smashed into powder. "compendium" (compendium): cherokee rose fruit, which is taken without reason, cannot be taken quickly; if essence qi is not consolidated, it is usually caused by other reasons. "

Maca, also known as maca. The maca is a plateau plant of cruciferae, contains unique macamides and macaenes, has a remarkable effect of balancing hormone secretion of a human body, has various health care and treatment effects and effects due to the fact that the maca contains various balanced and reasonable nutritional ingredients and various secondary metabolites with biological activity, can be used for enhancing energy, improving fertility, treating climacteric syndrome, rheumatism, depression and anemia in the prior art, and has the effects of resisting cancer, resisting leukemia and the like.

Lycium chinense, named as Chinese medicinal material, is the mature fruit of Lycium chinense of Solanaceae. The main functional indications are as follows: nourish kidney, moisten lung, tonify liver, improve vision. It is indicated for liver and kidney yin deficiency, soreness and weakness of waist and knees, dizziness, blurred vision, hyperdacryosis, cough due to asthenia, diabetes, and spermatorrhea. The pottery carries the potions, tonifies the essence and strengthens the vagina. Treatise on herb Property: has effects in replenishing vital essence, improving eyesight, and tranquilizing mind. Dietary therapy Ben Cao: strengthen tendons and resist aging, dispel wind, tonify tendons and bones, benefit people and relieve consumptive disease. Wang Hao Gu is a disease of heart disease of 21964m, dry heart, heart pain, thirst and drinking, and nephrosis. Compendium (compendium): nourish kidney, moisten lung and improve vision. The text of materia Medica: treating liver wind and blood deficiency, conjunctival congestion, pain, itching and nebula. It is used to treat apoplexy, vertigo, consumptive disease, blood syndrome, cough, anemia, nocturnal emission, red and white turbidity, beriberi and arthroncus.

Cistanche deserticola, named as traditional Chinese medicine, is the fleshy stem of cistanche deserticola or cistanche deserticola, labyring cistanche deserticola and the like, belonging to the family Orobanchaceae, and has the following main functions: tonify kidney, replenish essence, moisten dryness, and smooth intestine. The book Jing: treating overstrain and seven injuries, tonifying middle-jiao, removing cold and heat pain in stems, nourishing five internal organs, strengthening yin, benefiting essence and qi, and treating abdominal mass of women. The bibliography: remove pathogenic factors in bladder and lumbago, and stop dysentery. Rihuazi Bencao: it is used for treating male impotence, female infertility, internal organs moistening, muscle growing, waist and knee warming, male spermatorrhea, hematuria, enuresis, leukorrhagia, and vaginal pain.

The composition comprises, by weight, 0.1-1 part of toad venom, 0.1-1 part of cherokee rose fruit, 0.01-1 part of maca, 0.1-1 part of medlar and 0.01-1 part of cistanche deserticola, wherein the bacteriostatic agent is chlorhexidine acetate 0.01-0.5 part, the surfactant is polyoxyethylene sorbitan monooleate 0.01-1 part, the sweetening agent is 1-8 parts, ethanol 10-40 parts, and the balance of water (added to 100 parts). The preferable scheme is as follows: 0.2 part of toad venom, 0.5 part of cherokee rose fruit, 0.1 part of maca, 0.5 part of medlar, 0.1 part of desertliving cistanche, 0.1 part of polyoxyethylene sorbitan monooleate, 0.1 part of chlorhexidine acetate, 3.5 parts of glucose and 2.0 parts of cane sugar as sweetening agents, 25 parts of ethanol and the balance of water.

The preparation method of the composition for treating male sexual function comprises the steps of taking the toad venom and the additional traditional Chinese medicines as required, decocting with water or soaking in ethanol, wherein the ethanol with the existing concentration can be generally adopted, the preferable concentration range is 30-75%, or performing ultrasonic low-temperature extraction treatment on the water and the ethanol to obtain corresponding effective components, adding the surfactant, the sweetening agent and the bacteriostatic agent, and finally preparing the spray, the ointment, the liquid agent and the gel with the corresponding proportional content or attaching the gel to wet tissues. The decoction, soaking and low-temperature extraction are common technologies adopted by the existing traditional Chinese medicine treatment, and the final presentation of the compositions such as spray and the like can be realized by the existing technology, which is not repeated herein.

The relevant composition ratios and experimental data are as follows:

evaluation of improving time of sexual intercourse of men:

the effect is obvious (the time for one room is prolonged by more than 5 minutes), the effect is good (the time for one room is prolonged by more than 3 minutes), the effect is effective (the time for one room is prolonged by more than 1 minute), and the effect is ineffective (no time delay effect is indicated). 800 persons were tested and organized into 20 groups of 40 persons each. All examples were filled with the same size spray bottle and used 30-120 minutes before the same room, three times under the penis and glans corona spray.

Test group number	Example numbering	Obvious effect (human)	Better effect (human)	Effective (human)	Invalid (human)
						1	1	16	12	12	0
2	2	19	11	10	0
						3	3	23	10	7	0
4	4	20	10	10	0
						5	5	18	9	13	0
6	6	17	8	15	0
						7	7	19	8	13	0
8	8	23	9	6	0
						9	9	20	8	12	0
10	10	17	10	13	0
						11	11	20	10	10	0
12	12	22	9	9	0
						13	13	25	8	7	0
14	14	20	8	12	0
						15	15	15	10	15	0
16	16	20	8	12	0
						17	17	21	12	7	0
18	18	26	8	6	0
						19	19	20	5	15	0
20	20	16	7	17	0

As can be seen from the above table, all the examples are valid, with example 3, example 8, example 13, and example 18 being the best, and with example 13, 18 being superior to examples 3, 8.

The scheme belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a preparation of a product for improving the sexual intercourse time of men, which comprises the following components: venenum bufonis and additional traditional Chinese medicines; the auxiliary components comprise: surfactant (such as polyoxyethylene sorbitan monooleate and nonylphenol polyoxyethylene ether), sweetener (such as glucose and sucrose), and bacteriostatic agent (such as chlorhexidine acetate). The invention utilizes the time-delay effect of the toad venom, strengthens the time-delay effect by adding traditional Chinese medicines, increases the blood supply of penis and solves the problem of fatigue caused by prolonging the time of the same room; the surfactant of the auxiliary component enhances the transdermal effect, improves the absorption speed, reduces time lag, regulates the mouth feel of the product when the product is in contact with the mouth, and the bacteriostatic agent inhibits microorganisms. The compatibility of various traditional Chinese medicines is combined with auxiliary components, so that the sexual intercourse time of the male can be effectively improved.

The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the present invention, as it will be apparent to those skilled in the art that various modifications, combinations and variations can be made in the present invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the scope of the claims of the present invention.

Claims

1. A composition for treating male function, comprising: the composition consists of the following components: toad venom, a surfactant and a solvent.

2. The composition of claim 1, wherein the composition is for treating male sexual function: the composition also comprises additional traditional Chinese medicines for tonifying kidney and supporting yang.

3. The composition of claim 2, wherein the composition is for treating male sexual function: the composition comprises bacteriostatic agents and sweetening agents.

4. A composition for treating male sexual function according to claim 3, wherein: the solvent is one or two of water and ethanol.

5. The composition of claim 4, wherein the composition is for treating male sexual function: the additional Chinese medicinal materials are one or more of flos Caryophylli, fructus Cnidii, Rubi fructus, herba Epimedii, fructus Rosae Laevigatae, maca, fructus Lycii and Cistanchis herba.

6. The composition of claim 5, wherein the additional Chinese herbs are selected from clove, cnidium fruit, raspberry, and epimedium;

the composition comprises, by weight, 0.1-1 part of toad venom, 0.1-2 parts of clove, 0.1-1 part of fructus cnidii, 0.1-1 part of raspberry, 0.1-2 parts of epimedium herb, 0.01-0.5 part of chlorhexidine acetate serving as a bacteriostatic agent, 0.01-1 part of polyoxyethylene sorbitan monooleate serving as a surfactant, 0.1-2 parts of nonylphenol polyoxyethylene ether, 1-8 parts of a sweetening agent, 10-40 parts of ethanol and the balance of water.

7. The composition of claim 6, wherein said composition is for the treatment of male sexual function: 0.2 part of toad venom, 0.5 part of clove, 0.3 part of common cnidium fruit, 0.1 part of raspberry, 0.5 part of epimedium herb, 0.05 part of chlorhexidine acetate, 0.5 part of polyoxyethylene sorbitan monooleate, 0.8 part of nonylphenol polyoxyethylene ether, 3 parts of glucose and 1.5 parts of cane sugar as sweetening agents, 25 parts of ethanol and the balance of water.

8. The composition of claim 5, wherein the additional herbs are cherokee rose fruit, maca, wolfberry fruit, and cistanche deserticola;

9. The composition of claim 8, wherein said composition is for the treatment of male sexual function: 0.2 part of toad venom, 0.5 part of cherokee rose fruit, 0.1 part of maca, 0.5 part of medlar, 0.1 part of desertliving cistanche, 0.1 part of polyoxyethylene sorbitan monooleate, 0.1 part of chlorhexidine acetate, 3.5 parts of glucose and 2.0 parts of cane sugar as sweetening agents, 25 parts of ethanol and the balance of water.

10. A method of preparing a composition for treating male sexual function, comprising: