CN111658250B - 一种镍钛合金自膨胀支架及其制备方法 - Google Patents
一种镍钛合金自膨胀支架及其制备方法 Download PDFInfo
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- CN111658250B CN111658250B CN202010507294.2A CN202010507294A CN111658250B CN 111658250 B CN111658250 B CN 111658250B CN 202010507294 A CN202010507294 A CN 202010507294A CN 111658250 B CN111658250 B CN 111658250B
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- 229910001000 nickel titanium Inorganic materials 0.000 title claims abstract description 98
- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- 239000002105 nanoparticle Substances 0.000 claims abstract description 24
- OMZSGWSJDCOLKM-UHFFFAOYSA-N copper(II) sulfide Chemical compound [S-2].[Cu+2] OMZSGWSJDCOLKM-UHFFFAOYSA-N 0.000 claims abstract description 22
- 238000000576 coating method Methods 0.000 claims abstract description 20
- 239000011248 coating agent Substances 0.000 claims abstract description 19
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims abstract description 17
- 238000006243 chemical reaction Methods 0.000 claims abstract description 17
- 239000011593 sulfur Substances 0.000 claims abstract description 17
- 229910052717 sulfur Inorganic materials 0.000 claims abstract description 17
- 229920001690 polydopamine Polymers 0.000 claims abstract description 12
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims abstract description 10
- 229910052802 copper Inorganic materials 0.000 claims abstract description 10
- 239000010949 copper Substances 0.000 claims abstract description 10
- 238000005498 polishing Methods 0.000 claims abstract description 9
- 239000002253 acid Substances 0.000 claims abstract description 8
- 238000000034 method Methods 0.000 claims abstract description 8
- 239000002245 particle Substances 0.000 claims abstract description 8
- 238000005406 washing Methods 0.000 claims abstract description 8
- 239000000243 solution Substances 0.000 claims description 23
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 15
- 229910052751 metal Inorganic materials 0.000 claims description 13
- 239000002184 metal Substances 0.000 claims description 13
- HLXZNVUGXRDIFK-UHFFFAOYSA-N nickel titanium Chemical compound [Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni] HLXZNVUGXRDIFK-UHFFFAOYSA-N 0.000 claims description 13
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 claims description 11
- 238000004140 cleaning Methods 0.000 claims description 9
- 238000010438 heat treatment Methods 0.000 claims description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 6
- 239000012153 distilled water Substances 0.000 claims description 6
- 239000011259 mixed solution Substances 0.000 claims description 6
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 claims description 6
- 238000002791 soaking Methods 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 5
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 claims description 4
- 238000005238 degreasing Methods 0.000 claims description 4
- 229910017604 nitric acid Inorganic materials 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 3
- 229920002873 Polyethylenimine Polymers 0.000 claims description 3
- 229960000583 acetic acid Drugs 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
- 239000003792 electrolyte Substances 0.000 claims description 3
- 239000003517 fume Substances 0.000 claims description 3
- 239000012362 glacial acetic acid Substances 0.000 claims description 3
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 3
- 238000005554 pickling Methods 0.000 claims description 3
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 claims description 3
- 235000019345 sodium thiosulphate Nutrition 0.000 claims description 3
- 239000004809 Teflon Substances 0.000 claims description 2
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- -1 polytetrafluoroethylene Polymers 0.000 description 7
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- 230000002401 inhibitory effect Effects 0.000 description 3
- 201000002313 intestinal cancer Diseases 0.000 description 3
- QPJSUIGXIBEQAC-UHFFFAOYSA-N n-(2,4-dichloro-5-propan-2-yloxyphenyl)acetamide Chemical compound CC(C)OC1=CC(NC(C)=O)=C(Cl)C=C1Cl QPJSUIGXIBEQAC-UHFFFAOYSA-N 0.000 description 3
- 230000008855 peristalsis Effects 0.000 description 3
- 230000035755 proliferation Effects 0.000 description 3
- 206010063659 Aversion Diseases 0.000 description 2
- 241000167880 Hirundinidae Species 0.000 description 2
- BWFPGXWASODCHM-UHFFFAOYSA-N copper monosulfide Chemical compound [Cu]=S BWFPGXWASODCHM-UHFFFAOYSA-N 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
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- 229910052737 gold Inorganic materials 0.000 description 2
- 231100000053 low toxicity Toxicity 0.000 description 2
- 230000008569 process Effects 0.000 description 2
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- HZEWFHLRYVTOIW-UHFFFAOYSA-N [Ti].[Ni] Chemical compound [Ti].[Ni] HZEWFHLRYVTOIW-UHFFFAOYSA-N 0.000 description 1
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- 238000010030 laminating Methods 0.000 description 1
- 201000005264 laryngeal carcinoma Diseases 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
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Abstract
本发明提供一种镍钛合金自膨胀支架的制备方法,包括S10:对镍钛合金裸支架进行酸洗和抛光处理。S20:将载铜聚多巴胺颗粒附着在经过S10处理过的镍钛合金裸支架外表面。S30:制备硫源溶液。S40:将经过S20处理过的镍钛合金裸支架浸入硫源溶液,反应完毕后使得镍钛合金裸支架的外表面附着硫化铜纳米颗粒涂层。本发明还提供一种采用上述所述方法制备的镍钛合金自膨胀支架。本发明涉及的镍钛合金自膨胀支架及其制备方法能够有效避免支架的再狭窄给患者带来二次痛苦。
Description
技术领域
本发明涉及医疗器械技术领域,具体涉及一种镍钛合金自膨胀支架及其制备方法。
背景技术
近年来,肿瘤的多样性和多发性一直困扰着全球大部分患者和医生,尤其给患者的生活质量带来了太多的负面影响,比如食管癌、支气管癌、肠道癌等肿瘤的发生,严重影响着患者的生活质量。
目前对于食管癌、支气管癌、肠道癌等人体器官腔内所发生的肿瘤以及进而导致的腔道狭窄,多采用镍钛记忆合金自膨胀支架来缓解狭窄改善通路,此材质具有优良的生物相容性和耐腐蚀性,同时具有记忆特性和超弹性,及时置入自膨扩张支架可以有效缓解患者的多种症状,同时相对于化学和放射治疗而言,支架更是非常安全有效的方法。
光热治疗是通过近红外光照射的方法改变肿瘤细胞所处的环境,将光能转换为热能,被照射物达到一定温度后可杀死肿瘤细胞,从而达到治疗的目的。但是目前的腔道支架,不论是裸支架或者覆膜支架,均不具备光热疗法,即支架本身并不具有对腔道内的癌细胞的杀灭和抑制作用,因此在支架植入一段时间之后,异物感产生的组织增生以及癌细胞的进一步生长会导致支架内的再狭窄,从而给患者带来第二次痛苦。另外,对于裸支架型食管支架而言,裸支架的网格结构与其所伴随着的增生的发生会导致食管内食物蠕动的困难和阻力的增大,从而导致患者吞咽困难。对于包覆有硅胶膜的食管支架而言,在食管中部虽然有硅胶膜防止增生,并且也给食物的输送增加了顺滑性,但此硅胶膜的存在导致支架在食管内难以固定,从而引发支架移位,并且硅胶膜两端以外的裸支架部分同样会产生组织增生或肿瘤增生,从而在支架两侧产生狭窄。
发明内容
本发明要解决的技术问题是克服现有技术的不足,提供一种镍钛合金自膨胀支架及其制备方法,不仅可以使支架在器官腔道内稳定定位贴合更加紧密,促进和保证患者在平常生活中支架对于器官腔道蠕动的跟随性和联动性,同时还能够抑制器官腔道内肉芽组织增生和肿瘤增生,有效避免支架的再狭窄给患者带来二次痛苦。并且在腔道肿瘤的植入支架式治疗上还可利用光热疗法,即利用本发明的硫化铜纳米颗粒涂层的光热效应,抑制和杀灭腔道内的癌细胞,因此对于腔道肿瘤和狭窄的治疗上,本发明的伴有光热疗法的植入支架式治疗方案具有更好的应用前景。
为了解决上述技术问题,本发明提出的技术方案为:
一种镍钛合金自膨胀支架的制备方法,包括如下步骤:S10:对镍钛合金裸支架进行酸洗和抛光处理。S20:将载铜聚多巴胺颗粒附着在经过S10处理过的镍钛合金裸支架外表面。S30:制备硫源溶液。S40:将经过S20处理过的镍钛合金裸支架浸入硫源溶液,反应完毕后使得镍钛合金裸支架的外表面附着硫化铜纳米颗粒涂层。
根据本发明的镍钛合金自膨胀支架的制备方法,由于在镍钛合金裸支架外表面附着硫化铜纳米颗粒涂层,在红外线照射下具有发热的效果,患者可以定期检查器官腔道内的增生情况并进行红外线热疗法杀灭和抑制器官腔内的癌细胞,从而抑制器官腔内肉芽组织增生和肿瘤增生,有效避免支架的再狭窄给患者带来二次痛苦。并且,硫化铜纳米颗粒与传统的金纳米颗粒等光热材料相比,具有成本低、毒性低和高光热转化效率的优点,因而使得经过本制备方法的镍钛合金自膨胀支架在腔道肿瘤及狭窄的伴有光热疗法的植入支架式治疗上具有更好的应用前景。
对于上述技术方案,还可进行如下所述的进一步的改进。
根据本发明的镍钛合金自膨胀支架的制备方法,在一个优选的实施方式中,S10中,采用按重量计2.5%~3.5%的氢氟酸HF和13%~17%的硝酸HNO3在通风橱内的酸洗池对镍钛合金裸支架去油污处理15Min。采用高氯酸、冰醋酸和乙二醇的混合液作为电解液对酸洗后的镍钛合金裸支架进行电解抛光处理,控制电流大小和时间使镍钛合金裸支架外表面粗糙度达到0.1纳米。
这种酸洗和抛光处理过程,能够保证硫化铜纳米颗粒很好地附着在裸支架的外表面上,且能够保证植入之后患者的舒适度。
具体地,在一个优选的实施方式中,在S20中,包括如下子步骤:S201:将经过S10处理完毕的镍钛合金裸支架放入载铜聚多巴胺溶液中浸泡并搅拌,12小时后取出并用蒸馏水清洗。S202:将经过S201处理完毕的镍钛合金裸支架用载铜聚多巴胺溶液和聚乙烯亚胺的混合液浸泡并搅拌,12小时后取出并用蒸馏水清洗。
这种制备方式能够保证载铜聚多巴胺颗粒能够有效附着在镍钛合金裸支架的外表面。
具体地,在一个优选的实施方式中,在S30中,将预设量的硫代硫酸钠加入到预设剂量的乙二醇中超声并溶解获得硫源溶液,将硫源溶液置入水热高压反应釜中。
具体地,在一个优选的实施方式中,在S40中,包括如下子步骤:S401:将经过S20处理的镍钛合金裸支架放入含有硫源溶液的水热高压反应釜中,将反应釜加热至150摄氏度并保持10小时。S402:待反应完毕后取出镍钛合金裸支架,用无水乙醇清洗和烘干处理。
根据本发明第二方面的镍钛合金自膨胀支架,包括采用上述所述的制备方法制备的、外表面具有硫化铜纳米颗粒涂层的镍钛合金裸支架。
根据本发明第二方面的镍钛合金自膨胀支架,裸支架外表面能够紧贴患者器官腔道内壁,器官腔道内壁的组织增生会导致裸支架的内皮化,不仅可以使支架在器官腔道内稳定定位,贴合更加紧密,对于植入食管内的支架,能够促进和保证患者在吞咽食物时支架对于食管的跟随性和联动性,从而有效保证食物下咽的顺利。由于裸支架表面附着硫化铜纳米颗粒涂层,在红外线照射下具有发热的效果,患者可以定期检查器官腔道增生情况进行红外线热疗法杀灭和抑制器官腔内的癌细胞,抑制器官腔内肉芽组织增生和肿瘤增生,有效避免支架的再狭窄给患者带来二次痛苦,从而长期稳定地保证了支架植入的疗效。
对于上述技术方案,还可进行如下所述的进一步的改进。
根据本发明第二方面的的镍钛合金自膨胀支架,在一个优选的实施方式中,镍钛合金裸支架的内表面设有聚四氟乙烯薄膜。
镍钛合金裸支架内表面的聚四氟乙烯薄膜由于其自身的光滑性,也对食物的顺利下咽提供了更多的保障,同时整体无缝的薄膜又能抑制组织增生向支架内的发展,因此可以进一步抑制了支架的再狭窄的发生。
具体地,在一个优选的实施方式中,镍钛合金裸支架中部呈柱状结构,柱状结构两端设有喇叭口。
支架的两端成喇叭口的结构可以对整个支架进行简单固定,防止置入前期支架的滑动和移位。
具体地,在一个优选的实施方式中,喇叭口上远离柱状结构的端部套设有金属环,金属环的外表面附着硫化铜纳米颗粒涂层。
由于在喇叭口的最大边缘处设置具有硫化铜纳米颗粒涂层的金属环,在红外线照射下具有发热的效果,患者可以定期检查食管或者其他器官腔道增生情况进行红外线治疗,从而抑制食管支架或其他器官腔道支架边缘的肉芽组织增生绕过聚四氟乙烯薄膜向支架内部生长,防止支架两侧因增生产生支架内再狭窄的问题。
进一步地,在一个优选的实施方式中,金属环由镍钛合金丝构成,并且设置至少两组金属环。
通过在支架两侧进一步增加金属丝的密度,从而进一步增加支架两侧的光热治疗效果。
相比现有技术,本发明的优点在于:不仅可以使支架在器官腔道内稳定定位贴合更加紧密,促进和保证患者在平常生活中支架对于器官腔道蠕动的跟随性和联动性,同时还能够抑制器官腔道内肉芽组织增生和肿瘤增生,有效避免支架的再狭窄给患者带来二次痛苦。并且在腔道肿瘤的植入支架式治疗上还可利用光热疗法,即利用本发明的硫化铜纳米颗粒涂层的光热效应,抑制和杀灭腔道内的癌细胞,因此对于腔道肿瘤和狭窄的治疗上,本发明的伴有光热疗法的植入支架式治疗方案具有更好的应用前景。
附图说明
在下文中将基于实施例并参考附图来对本发明进行更详细的描述。其中:
图1示意性显示了本发明实施例的镍钛合金自膨胀支架10的径向视图;
图2示意性显示了本发明实施例的镍钛合金自膨胀支架10的轴向视图。
在附图中,相同的部件使用相同的附图标记。附图并未按照实际的比例绘制。
附图标记说明:10、镍钛合金自膨胀支架;1、裸支架;11、柱状结构;12、喇叭口;2、聚四氟乙烯薄膜;3、金属环。
具体实施方式
下面将结合附图和具体实施例对本发明作进一步详细说明,但并不因此而限制本发明的保护范围。
本发明实施例的镍钛合金自膨胀支架的制备方法,包括如下步骤:S10:对镍钛合金裸支架进行酸洗和抛光处理。S20:将载铜聚多巴胺颗粒附着在经过S10处理过的镍钛合金裸支架外表面。S30:制备硫源溶液。S40:将经过S20处理过的镍钛合金裸支架浸入硫源溶液,反应完毕后使得镍钛合金裸支架的外表面附着硫化铜纳米颗粒涂层。
根据本发明实施例的镍钛合金自膨胀支架的制备方法,由于在镍钛合金裸支架外表面附着硫化铜纳米颗粒涂层,在红外线照射下具有发热的效果,患者可以定期检查器官腔增生情况进行红外线热疗法杀灭和抑制器官腔内的癌细胞,从而抑制器官腔内肉芽组织增生和肿瘤增生,有效避免支架的再狭窄给患者带来二次痛苦。并且,硫化铜纳米颗粒与传统的金纳米颗粒等光热材料相比,具有成本低、毒性低和高光热转化效率的优点,因而使得经过本制备方法的镍钛合金自膨胀支架在腔道肿瘤及狭窄的伴有光热疗法的植入支架式治疗上具有更好的应用前景。
根据本发明实施例的镍钛合金自膨胀支架的制备方法,优选地,S10中,采用按重量计2.5%~3.5%的氢氟酸HF和13%~17%的硝酸HNO3在通风橱内的酸洗池对镍钛合金裸支架去油污处理15Min,尤其优选为采用按重量计3%的氢氟酸HF和15%的硝酸HNO3对镍钛合金裸支架去油污处理。采用高氯酸、冰醋酸和乙二醇的混合液作为电解液对酸洗后的镍钛合金裸支架进行电解抛光处理,控制电流大小和时间使镍钛合金裸支架外表面粗糙度达到0.1纳米。这种酸洗和抛光处理过程,能够保证硫化铜纳米颗粒很好地附着在裸支架的外表面上,且能够保证患者植入支架后的舒适度。
具体地,在本实施例中,在S20中,包括如下子步骤:S201:将经过S10处理完毕的镍钛合金裸支架放入载铜聚多巴胺溶液中浸泡并搅拌,12小时后取出并用蒸馏水清洗。S202:将经过S201处理完毕的镍钛合金裸支架用载铜聚多巴胺溶液和聚乙烯亚胺的混合液浸泡并搅拌,12小时后将镍钛合金裸支架取出并用蒸馏水清洗。这种制备方式能够保证载铜聚多巴胺颗粒能够有效附着在镍钛合金裸支架的外表面。
具体地,在本实施例中,在S30中,将预设量的硫代硫酸钠加入到预设剂量的乙二醇中超声并溶解获得硫源溶液,将硫源溶液置入水热高压反应釜中。
具体地,在本实施例中,在S40中,包括如下子步骤:S401:将经过S20处理的镍钛合金裸支架放入含有硫源溶液的水热高压反应釜中,将反应釜加热至150摄氏度并保持10小时。S402:待反应完毕后取出镍钛合金裸支架,用无水乙醇清洗和烘干处理。
图1示意性显示了本发明实施例的镍钛合金自膨胀支架10的径向视图。图2示意性显示了本发明实施例的镍钛合金自膨胀支架10的轴向视图。
如图1和图2所示,本发明第二方面实施例的镍钛合金自膨胀支架10,包括采用上述所述的制备方法制备的、外表面具有硫化铜纳米颗粒涂层的镍钛合金裸支架1。根据本发明第二方面实施例的镍钛合金自膨胀支架,裸支架外表面能够紧贴患者器官腔道内壁,器官腔道内壁的组织增生会导致裸支架的内皮化,不仅可以使支架在器官腔道内稳定定位,贴合更加紧密,对于植入食管内的支架,能够促进和保证患者在吞咽食物时支架对于食管的跟随性和联动性,从而有效保证食物下咽的顺利。由于裸支架表面附着硫化铜纳米颗粒涂层,在红外线照射下具有发热的效果,患者可以定期检查器官腔道增生情况进行红外线热疗法杀灭和抑制器官腔内的癌细胞,抑制器官腔内肉芽组织增生和肿瘤增生,有效避免支架的再狭窄给患者带来二次痛苦,从而长期稳定地保证了支架植入的疗效。
本发明第二方面实施例的镍钛合金自膨胀支架10,优选地,如图1和图2所示,镍钛合金裸支架1的内表面设有聚四氟乙烯薄膜2。镍钛合金内表面的聚四氟乙烯薄膜2由于其自身的光滑性,也对食物的顺利下咽提供了更多的保障,同时整体无缝的薄膜又能抑制组织增生向支架内的发展,因此可以进一步抑制了支架的再狭窄的发生。
如图1所示,具体地,在本实施例中,镍钛合金裸支架1中部呈柱状结构11,柱状结构11两端设有喇叭口12。支架的两端成喇叭口的结构可以对整个支架进行简单固定,防止置入前期支架的滑动和移位。优选地,柱状结构11为圆柱状或者椭圆柱状,从而便于植入器官腔道内。进一步地,如图1和图2所示,在本实施例中,喇叭口12上远离柱状结构11的端部套设有金属环3,金属环3的外表面附着硫化铜纳米颗粒涂层。由于在喇叭口的最大边缘处设置具有硫化铜纳米颗粒涂层的金属环,在红外线照射下具有发热的效果,患者可以定期检查食管或者其他器官腔道增生情况进行红外线治疗,从而抑制食管支架或其他器官腔道支架边缘的肉芽组织增生绕过聚四氟乙烯薄膜2向支架内部生长,防止支架两侧因增生产生支架内再狭窄的问题。进一步地,在本实施例中,金属环3由镍钛合金丝构成,并且设置至少两组金属环3。通过在支架两侧进一步增加金属丝的密度,从而进一步增加支架两侧的光热治疗效果。
本发明实施例所涉及的镍钛合金自膨胀支架结构和硫化铜纳米颗粒涂层方法虽然是针对治疗食管癌的食管支架,但对于其他非血管介入的器官腔内同样适用:针对支气管癌患者、喉管癌患者、肠道癌患者以及肠道梗阻患者,均可以在癌变位置的器官腔内植入本发明实施例的具有硫化铜纳米颗粒涂层的镍钛合金支架,从而实现在有效扩张腔道的同时也能在这些非血管的腔道内***近红外光探头达到光热治疗的效果,即杀灭和抑制癌细胞。
根据上述实施例,可见,本发明涉及的镍钛合金自膨胀支架及其制备方法:不仅可以使支架在器官腔道内稳定定位贴合更加紧密,促进和保证患者在平常生活中支架对于器官腔道蠕动的跟随性和联动性,同时还能够抑制器官腔道内肉芽组织增生和肿瘤增生,有效避免支架的再狭窄给患者带来二次痛苦。对于腔道肿瘤和狭窄的治疗上,本发明的伴有光热疗法的植入支架式治疗方案具有更好的应用前景。
虽然已经参考优选实施例对本发明进行了描述,但在不脱离本发明的范围的情况下,可以对其进行各种改进并且可以用等效物替换其中的部件。尤其是,只要不存在结构冲突,各个实施例中所提到的各项技术特征均可以任意方式组合起来。本发明并不局限于文中公开的特定实施例,而是包括落入权利要求的范围内的所有技术方案。
Claims (9)
1.一种镍钛合金自膨胀支架的制备方法,其特征在于,包括如下步骤:
S10:对镍钛合金裸支架进行酸洗和抛光处理;
S20:将载铜聚多巴胺颗粒附着在经过S10处理过的镍钛合金裸支架外表面;
S30:制备硫源溶液;将预设量的硫代硫酸钠加入到预设剂量的乙二醇中超声并溶解获得硫源溶液,将硫源溶液置入水热高压反应釜中;
S40:将经过S20处理过的镍钛合金裸支架浸入硫源溶液,反应完毕后使得镍钛合金裸支架的外表面附着硫化铜纳米颗粒涂层。
2.根据权利要求1所述的镍钛合金自膨胀支架的制备方法,其特征在于,S10中,
采用按重量计2.5%~3.5%的氢氟酸和13%~17%的硝酸在通风橱内的酸洗池对镍钛合金裸支架去油污处理15Min;
采用高氯酸、冰醋酸和乙二醇的混合液作为电解液对酸洗后的镍钛合金裸支架进行电解抛光处理,使镍钛合金裸支架外表面粗糙度达到0.1纳米。
3.根据权利要求1或2所述的镍钛合金自膨胀支架的制备方法,其特征在于,在S20中,包括如下子步骤:
S201:将经过S10处理完毕的镍钛合金裸支架放入载铜聚多巴胺溶液中浸泡并搅拌,12小时后取出并用蒸馏水清洗;
S202:将经过S201处理完毕的镍钛合金裸支架用载铜聚多巴胺溶液和聚乙烯亚胺的混合液浸泡并搅拌,12小时之后取出并用蒸馏水清洗。
4.根据权利要求1或2所述的镍钛合金自膨胀支架的制备方法,其特征在于,在S40中,包括如下子步骤:
S401:将经过S20处理的镍钛合金裸支架放入含有硫源溶液的水热高压反应釜中,将反应釜加热至150摄氏度并保持10小时;
S402:待反应完毕后取出镍钛合金裸支架,用无水乙醇清洗和烘干处理。
5.一种镍钛合金自膨胀支架,其特征在于,包括采用上述权利要求1至4中任一项所述的制备方法制备的、外表面具有硫化铜纳米颗粒涂层的镍钛合金裸支架(1)。
6.根据权利要求5所述的镍钛合金自膨胀支架,所述裸支架(1)的内表面设有聚四氟乙烯薄膜(2)。
7.根据权利要求5或6所述的镍钛合金自膨胀支架,其特征在于,所述裸支架(1)中部呈柱状结构(11),所述柱状结构(11)两端设有喇叭口(12)。
8.根据权利要求7所述的镍钛合金自膨胀支架,其特征在于,所述喇叭口(12)上远离所述柱状结构(11)的端部套设有金属环(3),所述金属环(3)的外表面附着硫化铜纳米颗粒涂层。
9.根据权利要求8所述的镍钛合金自膨胀支架,其特征在于,所述金属环(3)由镍钛合金丝构成,并且设置至少两组金属环(3)。
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