CN111643805A - Local analgesia microneedle device for neuropathic pain - Google Patents

Local analgesia microneedle device for neuropathic pain Download PDF

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Publication number
CN111643805A
CN111643805A CN202010632850.9A CN202010632850A CN111643805A CN 111643805 A CN111643805 A CN 111643805A CN 202010632850 A CN202010632850 A CN 202010632850A CN 111643805 A CN111643805 A CN 111643805A
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handle shell
telescopic
handle
neuropathic pain
column
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Chinese (zh)
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陆小龙
梅斌
王芬
郑旭东
陈韵如
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023Drug applicators using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046Solid microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061Methods for using microneedles

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  • Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Medical Informatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

The invention discloses a local analgesia microneedle device for neuropathic pain, which comprises a handle shell A, a handle shell B, a handle shell C and microneedle idler wheels, wherein the handle shell B is installed on one side of the handle shell A, a telescopic column A is arranged on one side, close to the middle position, of the handle shell B, a telescopic hole is formed in the middle position inside the handle shell B, the outer surface of the telescopic column A is sleeved on the inner surface of the telescopic hole, the handle shell C is installed on one side, away from the handle shell A, of the handle shell B, a telescopic groove is formed in one side, close to the telescopic hole, of the handle shell C, close to the middle position, of the handle shell B, the telescopic column B is arranged on one side, close to the middle position, of the handle shell C, away from the handle shell B, and a limiting hole is formed in the middle position of one side. The invention solves the problems of simple structure, large pain feeling during use and poor administration effect of the existing device, and improves the use effect and the use comfort.

Description

Local analgesia microneedle device for neuropathic pain
Technical Field
The invention relates to the field of treatment of neuropathic pain, in particular to a local analgesia microneedle device for neuropathic pain.
Background
Neuropathic pain is pain that results directly from damage or disease to the somatosensory system. The disease can be caused by peripheral nerve, spinal cord posterior root, spinal cord and some parts of central nerve above the spinal cord which are damaged by trauma and disease. The choice of drug for neuropathic pain should be based on the underlying pathogenesis of each patient. The medicines for treating chronic neuropathic pain mainly comprise anticonvulsants, tricyclic antidepressants, N-methyl-D-aspartic acid antagonists, ion channel blockers, non-steroidal anti-inflammatory drugs, local anesthetics, capsaicin receptor blockers, antihypertensive drugs, morphine drugs and GABA receptor agonists, and are mainly treated by oral medicines which have certain attenuation, so that a simpler and faster administration mode is urgently needed, and the microneedle technology is developed.
After a large number of searches, the following results are obtained: the invention has the following patent: application No. (CN 201810366608.4), publication No.: [ CN108553408A ] A local analgesic microneedle device for neuropathic pain and a preparation method thereof: the invention belongs to the technical field of medical analgesic products, and particularly discloses a local analgesic microneedle device for neuropathic pain and a preparation method thereof. The microneedle device comprises a microneedle substrate and a microneedle body arranged on the microneedle substrate, wherein the tip part of the microneedle body is provided with solid lipid nanoparticles, and the nanoparticles wrap medicine CGRP8-37 for treating neuropathic pain. The microneedle device can better realize the combination of microneedle painless administration and nanoparticle controlled release drugs, and the safe and side-effect-free CGRP8-37 drug is used for specifically treating local chronic neuropathic pain; in addition, in the aspect of administration mode, safe and painless administration can be realized by using the micro-needle, so that the pain caused by injection is greatly relieved; meanwhile, the nano particles are used for controlling the release of the medicine, so that the stability of the medicine in vivo can be improved, the medicine effect can be prolonged, the medicine toxicity can be reduced and the like, and good news can be brought to patients with neuropathic pain.
Chinese utility model patent: application number [ CN201521044694.5 ], bulletin number [ CN205391238U ] a shank neuropathic pain rehabilitation therapeutic apparatus: the invention discloses a crus neuropathic pain rehabilitation therapeutic apparatus, which is characterized in that a crus sleeve is a two-piece arc sleeve, an elastic binding band is arranged on the two-piece arc sleeve, the crus sleeve can be suitable for users with different leg circumferences, the application range is expanded, the inner wall of the two-piece arc sleeve and an electrode plate are fixed and separated through a cloth cover and a magic tape, the electrode plate can be moved according to the injured part of a patient, the use effect is ensured, a heating pad is arranged inside the cloth cover, blood circulation can be promoted through heating, ultraviolet disinfection lamps are arranged on two sections of the arc sleeve, the used sleeve can be disinfected, the sanitation condition is improved, and the crus neuropathic pain rehabilitation therapeutic apparatus has the advantages of wide adaptability and good human sanitation condition, and has wide market prospect.
The existing microneedle device is simple in structure, large in pain feeling during use and poor in drug administration effect, and therefore a local analgesia microneedle device for neuropathic pain is provided.
Disclosure of Invention
The invention aims to provide a local analgesia microneedle device for neuropathic pain, which has the advantage of convenient administration and solves the problems of simple structure, large pain feeling during use and poor administration effect of the existing device.
In order to achieve the purpose, the invention provides the following technical scheme: the utility model provides a local analgesia micropin device for neuropathic pain, includes handle casing A, handle casing B, handle casing C and micropin gyro wheel, its characterized in that: a handle shell B is installed on one side of the handle shell A, a telescopic column A is arranged on one side of the handle shell A close to the middle position of the handle shell B, a telescopic hole is formed in the middle position of the inside of the handle shell B, the outer surface of the telescopic column A is sleeved on the inner surface of the telescopic hole, a handle shell C is installed on one side of the handle shell B, which is far away from the handle shell A, a telescopic groove is formed in one side of the handle shell B, which is close to the telescopic hole, a telescopic column B is arranged on one side of the handle shell B, which is close to the middle position, the telescopic column B is sleeved inside the telescopic groove, a limiting hole is formed in the middle position of one side of the handle shell C, which is far away from the handle shell B, a spring is sleeved inside the limiting hole, a supporting column is sleeved on one side of the inner surface of the limiting hole, the support column end is installed the support frame, the support frame is close to support column internal surface both sides position department and installs the gyro wheel of adding medicine to through the boss thimble, it has the layer of adding medicine to add medicine gyro wheel surface mounting, the support frame both sides are close to bottom position department and are equipped with the locating hole, the support frame both sides are located locating hole internal surface mounting and have rubber shock pad, rubber shock pad internal surface mounting has the holding ring, the micropin gyro wheel is installed through the location axle to the holding ring internal surface, micropin gyro wheel surface mounting has the silica gel layer, silica gel layer.
Preferably, the outer surface of the telescopic column A and the inner surface of the telescopic hole are provided with a boss and a groove which are matched with each other, and the outer surface of the telescopic column B and the inner surface of the telescopic groove are provided with a boss and a groove which are matched with each other.
Preferably, the handle shell A and the handle shell B are connected through screwing threads, and the handle shell B and the handle shell C are connected through screwing threads.
Preferably, the middle positions of two sides of the medicine feeding roller are provided with positioning grooves, and the boss thimble is matched with the positioning grooves
Preferably, the rubber shock pads are arranged in two numbers, and the two rubber shock pads of the supporting plate are symmetrically arranged on the inner surface positions of the positioning holes on the two sides of the supporting frame respectively.
Preferably, the two sides of the support frame are provided with mounting openings at the upper ends of the positioning holes, and the inner surfaces of the mounting openings are connected to the inner surfaces of the positioning holes.
Preferably, a reinforcing rib is arranged in the middle of the inside of the support frame.
Compared with the prior art, the invention has the following beneficial effects:
1. according to the invention, the telescopic column A, the telescopic column B, the telescopic hole and the telescopic groove are arranged, so that the effect of prolonging and shortening the microneedle handle is achieved, the outer surface of the telescopic column A is sleeved on the inner surface of the telescopic hole, and the telescopic column B is sleeved inside the telescopic groove, so that the problem that a user cannot treat parts such as the back and the like due to insufficient product length is solved, and the applicability of the device is improved.
2. According to the invention, the spring is arranged in the limiting hole, so that the effect of protecting the affected part of the patient is achieved, the rubber shock absorption pads are arranged on the two sides of the supporting frame and positioned on the inner surfaces of the positioning holes, so that the problem that the affected part is painful due to excessive force applied by a user is solved, and the use comfort of the device is improved.
3. According to the invention, the medicine feeding roller wheels are arranged at the positions of the support frame, which are close to the two sides of the inner surface of the support column, through the boss ejector pins, so that the effect of conveniently feeding medicine to the needle head is achieved, the medicine feeding layer is arranged on the outer surface of the medicine feeding roller wheel, the problem of medicine strength attenuation after the needle head is used for a plurality of times is solved, and the using effect of the device is improved.
Drawings
FIG. 1 is a schematic front view of the present invention;
FIG. 2 is a partial front view of the handle housing of the present invention;
FIG. 3 is a partial cross-sectional structural view of the handle housing C of the present invention;
FIG. 4 is a schematic front view of the stand of the present invention;
FIG. 5 is a side view of the supporting frame of the present invention;
FIG. 6 is a schematic cross-sectional view of the loading roller of the present invention;
fig. 7 is a partial sectional structural schematic view of the microneedle roller according to the present invention.
In the figure: 1. a handle case A; 2. a handle housing B; 3. a handle housing C; 4. a support pillar; 5. a support frame; 6. a microneedle roller; 7. a telescopic column A; 8. a telescopic groove; 9. a telescopic hole; 10. a telescopic column B; 11. a limiting hole; 12. a limiting step; 13. a spring; 14. a boss thimble; 15. positioning the shaft; 16. a medicine feeding roller; 17. positioning holes; 18. a rubber shock pad; 19. a positioning ring; 20. a medicine applying layer; 21. positioning a groove; 22. a silica gel layer; 23. a needle.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the description of the present invention, it should be noted that the terms "upper", "lower", "inner", "outer", "front", "rear", "both ends", "one end", "the other end", and the like indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and be operated, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first" and "second" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In the description of the present invention, it is to be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "disposed," "connected," and the like are to be construed broadly, such as "connected," which may be fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
Referring to fig. 1 to 4, an embodiment of the present invention includes: a local analgesia microneedle device for neuropathic pains comprises a handle shell A1, a handle shell B2, a handle shell C3 and a microneedle roller 6, wherein one side of the handle shell A1 is provided with the handle shell B2, one side of the handle shell A1, which is close to the handle shell B2, is provided with a telescopic column A7, the middle position inside the handle shell B2 is provided with a telescopic hole 9, the outer surface of the telescopic column A7 is sleeved on the inner surface of the telescopic hole 9, the outer surface of the telescopic column A7 and the inner surface of the telescopic hole 9 are provided with mutually matched bosses and grooves, so that the handle of the local analgesia microneedle device is convenient to stretch, one side, which is far away from the handle shell A1, of the handle shell B2 is provided with a handle shell C3, the handle shell A1 and the handle shell B2 are connected with the handle shell B2 and the handle shell C3 through screwing threads, one side of the handle shell B2, one side, which is close to the middle position of the handle shell B5928, is provided with the telescopic column 10, the telescopic column B10 is sleeved inside the telescopic groove 8, the outer surface of the telescopic column B10 and the inner surface of the telescopic groove 8 are provided with a boss and a groove which are matched with each other, the handle of the invention is convenient to be stretched again, the using length is increased, the middle position of one side of the handle shell C3, which is far away from the handle shell B2, is provided with a limiting hole 11, the inside of the limiting hole 11 is sleeved with a spring 13 for relieving the problem of severe pain caused by excessive force, the inner surface of the limiting hole 11, which is positioned at one side of the spring 13, is sleeved with a supporting column 4, one end of the supporting column 4, which is positioned inside the limiting hole 11, is provided with a limiting step 12, the tail end of the supporting column 4 is provided with a supporting frame 5, the middle position of the inside of the supporting frame 5 is provided with a reinforcing rib for supporting the supporting frame 5, the positions, the two sides of the support frame 5 are provided with positioning holes 17 near the bottom end, the two sides of the support frame 5 are provided with rubber shock pads 18 on the inner surfaces of the positioning holes 17, positioning rings 19 are arranged on the inner surfaces of the rubber shock pads 18, microneedle idler wheels 6 are arranged on the inner surfaces of the positioning rings 19 through positioning shafts 15, silica gel layers 22 are arranged on the outer surfaces of the microneedle idler wheels 6, and needles 23 are arranged on the outer surfaces of the silica gel layers 22.
Referring to fig. 5 to 7, an embodiment of the present invention includes: a local analgesia microneedle device for neuropathic pains comprises a handle shell A1, a handle shell B2, a handle shell C3 and microneedle rollers 6, wherein one side of the handle shell A1 is provided with a handle shell B2, one side of the handle shell A1, which is close to the handle shell B2, is provided with a telescopic column A7 near the middle position, the middle position inside the handle shell B2 is provided with a telescopic hole 9, the outer surface of the telescopic column A7 is sleeved on the inner surface of the telescopic hole 9, one side of the handle shell B2, which is far away from the handle shell A1, is provided with a handle shell C3, one side of the handle shell B2, which is close to the telescopic hole 9, is provided with a telescopic groove 8, one side of the handle shell C3, which is close to the middle position, is provided with a telescopic column B10, the telescopic column B10 is sleeved inside the telescopic groove 8, one side of the handle shell C3, which is far away from the handle shell B2, is provided with a limit hole 11, a spring 13 is sleeved inside the limit hole 11, and one side, one end of a supporting column 4 is positioned in a limiting hole 11 and is provided with a limiting step 12, the tail end of the supporting column 4 is provided with a supporting frame 5, the supporting frame 5 is provided with a medicine feeding roller 16 at the positions close to the two sides of the inner surface of the supporting column 4 through a boss thimble 14, the middle positions of the two sides of the medicine feeding roller 16 are provided with positioning grooves 21, the boss thimble 14 is matched with the positioning grooves 21 so as to be convenient for the disassembly and the assembly of the medicine feeding roller 16, the outer surface of the medicine feeding roller 16 is provided with a medicine feeding layer 20, the positions of the two sides of the supporting frame 5 close to the bottom end are provided with positioning holes 17, the inner surfaces of the positioning holes 17 at the two sides of the supporting frame 5 are provided with rubber shock pads 18, the two supporting plate rubber shock pads 18 are symmetrically arranged at the positions of, support frame 5 both sides are located locating hole 17 upper end position department and are equipped with the installing port, and the interior surface connection of installing port is in locating hole 17 internal surface position department, and 19 internal surfaces of holding ring install micropin gyro wheel 6 through location axle 15, the dismantlement and the installation of the micropin gyro wheel 6 of being convenient for, and 6 outer surface mounting of micropin gyro wheel have silica gel layer 22, 22 outer surface mounting syringe needles 23 on silica gel layer.
The working principle is as follows: after the device is installed, the medicine feeding roller 16 is taken out of the protective box, the protective box is installed on boss thimbles 14 at two sides, the microneedle roller 6 is taken out, the positioning shaft 15 on the microneedle roller 6 is clamped into the positioning ring 19 through the installation port, the affected part can be rolled for treatment, when the microneedle roller continuously rolls, the needle head 23 on the microneedle roller 6 continuously penetrates into the medicine feeding layer 20 to complete medicine feeding and then penetrates into the skin for treatment, when some affected parts cannot be reached by using the device, the handle shell A1 is rotated, the joint of the handle shell A1 and the handle shell B2 is unscrewed, the handle shell A1 and the handle shell B2 are pulled apart, the telescopic bosses on the telescopic column A7 are clamped in the inner grooves of the holes 9, if the length is not enough, the joint of the handle shell B2 and the handle shell C3 is unscrewed, the handle shell B2 and the handle shell C3 are pulled apart, and the bosses on the telescopic column B10 are clamped in the inner grooves of the telescopic grooves 8, after the use, the medicine feeding roller 16 is taken down and placed in the protective box, the microneedle roller 6 is taken down and placed in the protective box for storage after disinfection, and then the working process of the invention is completed.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.

Claims (7)

1. A local analgesia micropin device for neuropathic pain, includes handle casing A (1), handle casing B (2), handle casing C (3) and micropin gyro wheel (6), its characterized in that: the handle is characterized in that a handle shell B (2) is installed on one side of a handle shell A (1), a telescopic column A (7) is arranged on one side, close to the middle position, of the handle shell B (2) of the handle shell A (1), a telescopic hole (9) is formed in the middle position inside the handle shell B (2), the outer surface of the telescopic column A (7) is sleeved on the inner surface of the telescopic hole (9), a handle shell C (3) is installed on one side, away from the handle shell A (1), of the handle shell B (2), a telescopic groove (8) is formed in one side, located on one side, close to the telescopic hole (9), of the handle shell C (3), a telescopic column B (10) is arranged on one side, located on one side, of the handle shell B (2), of the telescopic column B (10) is sleeved inside the telescopic groove (8), a limiting hole (11) is formed in the middle position, away from one side, away from the handle shell B (2), of the handle shell C (3), spring (13) is sleeved in the limiting hole (11), the inner surface of the limiting hole (11) is located on one side of the spring (13) and is sleeved with a supporting column (4), one end of the supporting column (4) is located in the limiting hole (11) and is internally provided with a limiting step (12), a supporting frame (5) is installed at the tail end of the supporting column (4), the supporting frame (5) is close to the positions of the two sides of the inner surface of the supporting column (4) and is provided with a medicine feeding roller (16) through a boss thimble (14), the outer surface of the medicine feeding roller (16) is provided with a medicine feeding layer (20), the positions of the two sides of the supporting frame (5) close to the bottom end are provided with positioning holes (17), the inner surfaces of the two sides of the supporting frame (5) are provided with rubber shock pads (18), the inner surfaces of the rubber shock pads (18) are provided with, the outer surface of the microneedle roller (6) is provided with a silica gel layer (22), and the outer surface of the silica gel layer (22) is provided with a needle head (23).
2. The local analgesic microneedle device for neuropathic pain according to claim 1, wherein: the outer surface of the telescopic column A (7) and the inner surface of the telescopic hole (9) are provided with bosses and grooves which are matched with each other, and the outer surface of the telescopic column B (10) and the inner surface of the telescopic groove (8) are provided with bosses and grooves which are matched with each other.
3. The local analgesic microneedle device for neuropathic pain according to claim 1, wherein: the handle shell A (1) is connected with the handle shell B (2) through screwing threads, and the handle shell B (2) is connected with the handle shell C (3) through screwing threads.
4. The local analgesic microneedle device for neuropathic pain according to claim 1, wherein: and a positioning groove (21) is formed in the middle position of the two sides of the medicine feeding roller (16), and the boss ejector pin (14) is matched with the positioning groove (21).
5. The local analgesic microneedle device for neuropathic pain according to claim 1, wherein: the rubber shock absorption pads (18) are arranged in two, and the two supporting plate rubber shock absorption pads (18) are symmetrically arranged on the inner surface positions of the positioning holes (17) on the two sides of the supporting frame (5).
6. The local analgesic microneedle device for neuropathic pain according to claim 1, wherein: the two sides of the support frame (5) are provided with mounting openings at the upper ends of the positioning holes (17), and the inner surfaces of the mounting openings are connected to the inner surfaces of the positioning holes (17).
7. The local analgesic microneedle device for neuropathic pain according to claim 1, wherein: and reinforcing ribs are arranged in the middle of the inside of the support frame (5).
CN202010632850.9A 2020-07-02 2020-07-02 Local analgesia microneedle device for neuropathic pain Pending CN111643805A (en)

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CN112691012A (en) * 2020-12-30 2021-04-23 北京轻奢国济医疗美容诊所有限公司 Three-dimensional integrative self-repairing device of micropin

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