CN111631964A

CN111631964A - Striae gravidarum repair cream and preparation method thereof

Info

Publication number: CN111631964A
Application number: CN202010554773.XA
Authority: CN
Inventors: 唐鸣; 范小玲
Original assignee: Guangzhou Ocean Cosmetic Co ltd
Current assignee: Guangzhou Ocean Cosmetic Co ltd
Priority date: 2020-06-17
Filing date: 2020-06-17
Publication date: 2020-09-08

Abstract

The invention discloses a striae gravidarum repair cream and a preparation method thereof, belonging to the technical field of cosmetics, and comprising xanthan gum, glycerol, hexanediol, pentanediol, a humectant, potassium cetearyl phosphate, cetearyl alcohol, glyceryl stearate, vitamin E (tocopherol), squalane, phytosterols, bisabolol, olive oil, argan oil, lavender oil, camellia seed oil, hydrolyzed collagen, calcium sodium phosphosilicate, a centella asiatica extract, a purslane extract, folic acid, an aloe extract and the balance of deionized water; stirring and homogenizing in an emulsifying pot until the components are completely dissolved, heating, keeping the temperature for 30 minutes, mixing and homogenizing, defoaming in vacuum, cooling, stirring uniformly, continuing cooling, stirring uniformly, sampling, controlling, and discharging to obtain a finished product. The obtained stretch mark repair cream can effectively prevent and repair stretch marks, avoids the formation of stretch marks, and has mild and safe components and no stimulation.

Description

Striae gravidarum repair cream and preparation method thereof

Technical Field

The invention relates to the technical field of cosmetics, and particularly belongs to striae gravidarum repair cream and a preparation method thereof.

Background

Each woman can generate striae gravidarum in different degrees in the gestation period and the abdomen after childbirth, which seriously affects the beauty of the human body and also causes great psychological stress. How to solve stretch marks brought during pregnancy becomes a major issue for cosmetic formulators.

The hormone change of women is large in gestation period, and the abdominal bulge damages or breaks elastic fibers and collagen fibers of the skin, so that the abdominal skin becomes thin and thin, and pink or purple wavy patterns with different widths and lengths appear. After delivery of a woman, these patterns gradually disappear, leaving white or silvery-white, shiny scar lines, which are what we often say as stretch marks. Once the striae gravidarum is formed, the striae gravidarum is basically not repaired and disappeared by self. Therefore, many women are seriously troubled by the pregnant woman after the pregnant woman finishes the birth, and the pregnant woman striae repairing cream can be eliminated by the best method.

However, the quality of the striae gravidarum repair cream on the market is uneven, stimulation is easily generated on tender skin of the abdomen, the current striae gravidarum repair cream is used for repairing after striae gravidarum is generated, even if part of the repair cream is integrated with prevention and treatment, the function of the repair cream is important for later repair, and the repair cream is used by being smeared at the later stage of pregnancy or after parturition and is slowly repaired. At this time, the striae gravidarum is already formed, and is difficult to repair, and the repair cost is also high. Not only takes a long time to repair, but also is time and effort consuming, and is costly or even impossible to repair.

Disclosure of Invention

Aiming at the defects and shortcomings in the background technology, the stretch mark repairing cream provided by the invention can prevent and fade stretch marks, avoid the appearance of stretch marks in the middle and later periods of pregnancy or postpartum, fundamentally solve the problem of skin troubles brought to women by stretch marks, and is mild in components and free of stimulation.

The second purpose of the invention is to provide a preparation method of the stretch mark repair cream, which has simple preparation steps, can keep the activity of each substance, and can ensure that the substances can be fully mixed and reacted, thereby being beneficial to improving the efficacy and the effect of a finished product and reducing the irritation of components.

In order to realize the purpose, the invention adopts the following technical scheme to realize the purpose:

a striae gravidarum repair cream comprises a component A, a component B and a component C;

wherein the component A comprises the following substances in percentage by mass: 0.05 to 0.3 percent of xanthan gum, 5.0 to 8.0 percent of glycerol, 1.0 to 2.0 percent of hexanediol, 2.0 to 3.0 percent of pentanediol and 8.0 to 13.3 percent of humectant;

the component B comprises the following substances in percentage by mass: 2.0-3.0% of potassium cetearyl phosphate, 2.0-5.0% of cetearyl alcohol, 2.0-5.0% of glyceryl stearate, 1.0-3.0% of vitamin E (tocopherol), 3.0-5.0% of squalane, 0.5-1.0% of phytosterol, 0.2-0.5% of bisabolol, 2.0-5.0% of olive (Olea EUROPAEA) fruit oil, 2.0-3.0% of argan tree (ARGANIA SPINOSA) kernel oil, 1.0-3.0% of lavender (LAVANDULA ANGUSTIFOLIA) oil and 1.0-2.0% of CAMELLIA (CAMELLIA JAPONICA) seed oil;

the component C comprises the following substances in percentage by mass: 0.5-3.0% of hydrolyzed collagen, 3.0-8.0% of calcium phosphosilicate and 0.5-3.0% of centella asiatica (CENTELLA ASIATICA) extract;

the component D comprises the following substances in percentage by mass: 0.1 to 0.5 percent of purslane extract, 0.05 to 0.1 percent of folic acid and 0.1 to 0.3 percent of aloe extract;

the balance being deionized water.

Further measures taken are: the component A comprises the following substances in percentage by mass: 0.05 to 0.26 percent of xanthan gum, 5.5 to 8.0 percent of glycerol, 1.3 to 1.8 percent of hexanediol, 2.1 to 3.0 percent of pentanediol and 8.0 to 13.2 percent of humectant;

the component B comprises the following substances in percentage by mass: 2.2-3.0% of potassium cetearyl phosphate, 2.5-4.0% of cetearyl alcohol, 2.0-4.5% of glyceryl stearate, 2.5-3.0% of vitamin E (tocopherol), 3.5-5.0% of squalane, 0.5-0.7% of phytosterol, 0.2-0.4% of bisabolol, 3.5-5.0% of olive (Olea EUROPAEA) fruit oil, 2.2-2.8% of argan tree (ARGANIA SPINOSA) kernel oil, 1.0-2.5% of lavender (lavandula angustifolia) oil and 1.0-1.8% of CAMELLIA (CAMELLIA JAPONICA) seed oil;

the component C comprises the following substances in percentage by mass: 0.5-3.0% of hydrolyzed collagen, 4.0-8.0% of calcium phosphosilicate and 1.5-3.0% of centella asiatica (CENTELLA ASIATICA) extract;

the component D comprises the following substances in percentage by mass: 0.2 to 0.5 percent of purslane extract, 0.06 to 0.1 percent of folic acid and 0.1 to 0.3 percent of aloe extract;

the balance being deionized water.

Further measures taken are: the component A comprises the following substances in percentage by mass: 0.05% of xanthan gum, 8.0% of glycerol, 1.5% of hexanediol, 3.0% of pentanediol and 10.05% of humectant;

the component B comprises the following substances in percentage by mass: 3.0% of potassium cetearyl phosphate, 4.0% of cetearyl alcohol, 2.0% of glyceryl stearate, 3.0% of vitamin E (tocopherol), 5.0% of squalane, 0.5% of phytosterols, 0.3% of bisabolol, 5.0% of olive (Olea EUROPAEA) fruit oil, 2.8% of argan SPINOSA (ARGANIA SPINOSA) kernel oil, 1.0% of lavender (LAVANDULA ANGUSTIFOLIA) oil, and 1.5% of CAMELLIA (CAMELLIA JAPONICA) seed oil;

the component C comprises the following substances in percentage by mass: 3.0% of hydrolyzed collagen, 8.0% of calcium phosphosilicate and 3.0% of centella asiatica (CENTELLA ASIATICA) extract;

the component D comprises the following substances in percentage by mass: 0.5% of purslane extract, 0.1% of folic acid and 0.3% of aloe extract;

the balance being deionized water.

Further measures taken are: the humectant comprises 6.0-8.0% of butanediol, 2.0-5.0% of urea and 0.05-0.3% of sodium hyaluronate.

Further measures taken are: the humectant comprises 1.0-2.0% of betaine, 0.5-1.5% of trehalose, 260.5-1.0% of polyglycerol ether, 100.5-1.0% of polyglycerol and 4004.0-8.0% of polyvinyl alcohol.

Further measures taken are: the calcium sodium phosphosilicate is a nano-grade material, and the particle size of the material is 5-10 microns.

Further measures taken are: the hydrolyzed collagen is derived from fish scales, cod skin and tendon tissue of cattle, and is prepared by the following steps: respectively pretreating fish scales, cod skin and tendon tissue of cattle, and mixing the pretreated fish scales, cod skin and tendon tissue of cattle in a ratio of 1: and 3:7.5, mixing uniformly, extracting by subcritical fluid, adding a compound enzyme of collagenase, trypsin, papain and decarboxylase for enzymolysis, wherein the nominal activity of the compound enzyme is 1.7-1.9AU-N/g, filtering by an ultrafiltration membrane with the molecular weight cutoff of 6-15kDa, purifying and concentrating by an RO reverse osmosis membrane, and drying under a microwave vacuum low-temperature environment to obtain the hydrolyzed collagen.

Further measures taken are: the mass percentage ratio of the olive (Olea EUROPAEA) fruit oil to the argania spinosa (Arganiaspinosa) kernel oil is 1: (1.7-2.1).

Further measures taken are: the ratio of the mass percent of the calcium sodium phosphosilicate to the mass percent of the centella asiatica (CENTELLAASIATICA) extract is 1: (2.6-2.7).

A preparation method of stretch mark repair cream comprises the following steps:

s1: adding the substances of the component A in the corresponding mass percentage and the deionized water in the corresponding mass percentage into an emulsifying pot, stirring and homogenizing until the substances are completely dissolved, heating to 85-90 ℃, and preserving heat for 30 minutes for later use;

s2: adding the substances of the component B in corresponding mass percentage into an oil phase pot, heating and stirring to 80-85 ℃ until the substances are completely dissolved;

s3: pumping the component B completely dissolved in the step S2 into an emulsifying pot of the component A to be used, homogenizing for 5-8min, defoaming in vacuum, and cooling;

s4: when the temperature of the component in the step S3 is reduced to 50 ℃, adding the dissolved component C with corresponding mass percentage, stirring uniformly, and continuously reducing the temperature;

s5: and (5) when the mixture in the step S4 is cooled to 40 ℃, adding the component D with the corresponding mass percentage, uniformly stirring, sampling, controlling, and discharging to obtain a finished product.

Further measures taken are: when vacuum defoaming is carried out in the step 3, cold water spraying is adopted for rapid cooling, and the cold water spraying is stopped after the temperature is reduced to 55 ℃, and the temperature is slowly reduced;

in the step S5, after the component D is added and stirred uniformly, the pH is adjusted and controlled between 7.35 and 7.40.

According to the stretch mark repair cream, the polyhydric alcohol is used as the preservative, so that the preservative is milder, and the irritation of the product to the skin is reduced; adding vegetable oil such as olive (Olea EUROPAEA) fruit oil, ARGANIA SPINOSA (Argania SPINOSA) kernel oil, lavender (Lavandula ANGUSTIFOLIA) oil, and CAMELLIA (Camellia JAPONICA) seed oil, mildly supplementing skin nutrition, and increasing skin elasticity; nanometer calcium sodium phosphosilicate, centella asiatica (CENTELLA ASIATICA) extract, purslane extract (sensitive skin during pregnancy, purslane can be used for relieving skin and resisting sensitivity), folic acid (good anti-inflammatory effect, cell growth and division promotion and good protection effect during pregnancy), aloe extract (sensitive redness of skin, susceptibility to infection and effective relief caused by hormone disorder in a special period) and other raw materials are added, hydrolyzed collagen treated by a special process is added, the effects of excellent absorption and tissue cell repair, proliferation and differentiation promotion are achieved, scientific compatibility of other preferable raw material components is added, so that the damage of elastic fiber and collagen fiber is repaired, the effect of preventing and relieving striae gravidarum is achieved, when the skin fiber is used in the early pregnancy, when irreversible damage is not formed on the striae gravidarum, the skin fiber is repaired from the root, and the formation of striae gravidarum is avoided, thereby solving the problem of skin troubles brought to women by striae gravidarum.

In addition, various repairability raw materials are selected, the selection of an emulsifier, a thickening agent, an anticorrosion system and the like is strictly screened, and the mixture ratio of the materials is strictly added according to requirements. In order to exert the strong repairing activity of the calcium sodium phosphosilicate (Regesi) to the maximum extent, the production process is strictly controlled, the pH is accurately controlled to be between 7.35 and 7.40, and the stability of the system is ensured.

The argania spinosa kernel oil is slightly deficient in oxidation resistance and nutrition compared with grape seed oil and olive oil, is generally used in dyeing and scalding and basic skin care, and is not applied to prevention of early striae gravidarum or plays an obvious role in the whole body. However, through intensive research, the olive oil and the calcium sodium phosphosilicate have excellent effects of lubricating and smoothing skin when being matched with olive oil and calcium sodium phosphosilicate, and meanwhile, the mass percentage ratio of the olive fruit oil to the argania spinosa kernel oil is controlled to be 1: (1.7-2.1) and can play an important promoting role in preventing striae gravidarum.

The used calcium sodium phosphosilicate is a nano-scale material, the particle size of the material is between 5 and 10 micrometers, Ca2+ in the calcium sodium phosphosilicate is subjected to ion exchange with H + or H3O + in liquid to form silicon hydroxyl groups Si-OH, the silicon hydroxyl groups are mutually polymerized to form Si-OH + HO-Si → Si-O-Si, so that a layer of negatively charged silicon gel layer is formed on the surface of the material, the gel layer adsorbs Ca2+, PO43-, CO 32-and OH-, and is precipitated in the form of amorphous salt, and HCA with a regular three-dimensional network structure is formed by crystal bloom [ Ca10(PO4CO3)6(OH)2 ]. The three-dimensional network structure has good induction and biological signal transduction capabilities on cells, can provide a support for the cells to live, becomes a carrier of nutrient substances and a bridge for cell climbing, and adsorbs and gathers various substances related to tissue regeneration, such as: fibrin, collagen, stem cells and various repair factors improve the nutrient environment and microcirculation of the wound surface, so that the cells can be orderly regenerated in situ; more importantly, the release of phosphorus ions can be regulated and controlled along with the in vivo environment, the degradation speed of the material is controlled, and the tissue can be subjected to in-situ repair in a self-induced manner.

Through the technical scheme, compared with the prior art, the invention has the following beneficial effects:

1. the invention can promote the proliferation and differentiation of tissue cells, repair the damages of elastic fibers and collagen fibers from the root and play a role in preventing and lightening striae gravidarum, thereby solving the problem of skin troubles brought to women by striae gravidarum, and the invention has excellent effect, safety and no stimulation.

2. The preparation method is simple and effective, can effectively protect the activity of each component, ensures the stability of a system, enables the prepared stretch mark repair cream to exert the optimal effect, and inhibits the irritation of the components, thereby achieving the remarkable effects of preventing and fading stretch marks, and being mild and non-irritating.

Drawings

FIG. 1 is a histogram of the striae gravidarum incidence rate of the effect tests of examples 1-5 and control groups 2-4.

Detailed Description

In order to clearly understand the technical solutions adopted by the present invention, the following description is made on the preferred embodiments of the present invention, and it should be understood that the embodiments described herein are only used for illustrating and explaining the present invention, and are not used to limit the present invention.

Examples 1 to 5: a striae gravidarum repair cream comprises a component A, a component B, a component C and a component D; the components and mass percentages thereof included in the examples, and the components and mass percentages thereof included in the control group 1 are shown in the following table 1:

table 1: components and proportions of the examples and comparative examples

Examples 1-5 above, as well as control 1, were prepared by the following preparation method, including the steps of:

When vacuum defoaming is carried out in the step 3, cold water spraying is adopted for rapid cooling, and the cold water spraying is stopped after the temperature is reduced to 55 ℃, and the temperature is slowly reduced;

in step S5, the pH is adjusted after adding component D and stirring uniformly, and the pH is controlled between 7.35-7.40.

Wherein the hydrolyzed collagen is derived from fish scales, cod skin and bovine tendon tissue, and is prepared by the following steps: respectively pretreating fish scales, cod skin and tendon tissue of cattle, and mixing the pretreated fish scales, cod skin and tendon tissue of cattle in a ratio of 1: 3:7.5, mixing uniformly, extracting by subcritical fluid, adding a compound enzyme of collagenase, trypsin, papain and decarboxylase for enzymolysis, wherein the nominal activity of the compound enzyme is 1.7-1.9AU-N/g, filtering by an ultrafiltration membrane with the molecular weight cutoff of 6-15kDa, purifying and concentrating by an RO reverse osmosis membrane, and drying under a microwave vacuum low-temperature environment to obtain the hydrolyzed collagen.

Note that: (1) when defoaming in vacuum, the temperature is quickly reduced firstly, and then the temperature is naturally and slowly reduced, so that the performance of the substance is protected and defoaming is accelerated; (2) meanwhile, the accurate adjustment of pH is noticed, and the activity of the components is easily influenced and certain irritation is generated when the pH is too low or too high, and the pH must be controlled to be between 7.35 and 7.40 so as to ensure the optimal performance of the whole components and mild and no irritation; (3) finally, the whole preparation process is strictly executed according to the temperature and the heat preservation time of each step, and the best finished product effect can be obtained; (4) use is initiated early in pregnancy, particularly at 4-8 weeks, and is discontinued until two weeks prior to the expected period of production.

(I), the striae gravidarum repair cream of the present examples 1-5 was subjected to performance index test according to cosmetic implementation standard QB/T1857, and the results were as follows:

1. appearance: light yellow paste.

pH value of 6.0-7.5, measured 7.36.

3. And (3) investigating heat resistance stability: keeping the temperature at (40 +/-1) ℃ for 24 hours, recovering the room temperature without oil-water separation, and testing the heat resistance stability to be qualified.

4. And (3) cold resistance stability investigation: keeping the temperature at (-8 +/-2) DEG C for 24 hours, recovering the room temperature without obvious oil leakage, and testing the cold resistance stability to be qualified.

Second, the striae gravidarum repair cream of examples 1-5 and control group 1 was subjected to skin irritation test, and the test procedure and results were as follows:

selecting 70 female mice with sexual maturity in the same batch and 70 male mice with sexual maturity in the same batch, breeding the female mice and the male mice in a 1:1 matched cage for 4-6 days for mating, and then separating out 70 female mice. The female mice were observed for 2 to 3 days, and pregnant female mice were selected from them. Finally, 63 pregnant females are selected, 3 pregnant females are randomly removed, and the rest 60 pregnant females constitute test mice for skin irritation test.

The 60 test mice were randomly grouped into groups of 10 mice each and 6 mice each, and skin irritation tests were performed on the skin with the stretch mark repair creams of examples 1 to 5 and control group 1, respectively, while keeping the feeding environment, feed and water of all the test mice as the same as possible in the next skin irritation test.

Before the skin irritation test, the hairs on both sides of the spinal column of 6 groups of test mice were cut off, the epidermis was not damaged, and the hair removal range on the left and right sides was about 3cm × 3 cm. Respectively adopting 0.5mL (g) of repair cream corresponding to the embodiment or the comparative example to directly coat the repair cream on the unhaired skin on one side of the spine, and then using two layers of gauze and non-irritant adhesive plaster to carry out covering and fixing treatment on the unhaired skin; the skin on the other side was not smeared with anything, and was covered with only two layers of gauze and a non-irritating adhesive tape as a blank control. Smearing the repair cream on the same part for 1-2 times every day, observing and recording the reaction phenomenon and the pregnancy state of the skin on two sides of the spinal column of the mouse every day, continuing for 21 days until the test mouse gives birth, and summarizing the conditions of the final test result.

The results show that: no skin irritation reaction such as skin redness, eruption, water pimples and the like is found on the skin of a test mouse after the repair cream of the embodiment 1-5 is applied for 21 days, and compared with the skin on two sides of the spine, the skin applied with the repair cream of the embodiment 1-8 on one side of the spine is smoother and finer than the skin without any substance applied on the other side; meanwhile, the test mouse does not show any abnormal reaction in the whole gestation period, normal delivery is realized, and all the fetal development is normal. While the skin of 1 test mouse smeared with the repair cream of the control group 1 slightly rubs after smearing, and returns to normal after 1 day of stopping smearing, which belongs to slight allergy; the skin of other mice coated with the repair cream of the control group 1 appeared normal, and after the continuous coating for 21 days, the delivery was normal, and the fetus developed normally.

Therefore, the repair creams of the embodiments 1 to 5 are mild and safe, and have no irritation even after long-term use; the test mice using the control 1 repair cream showed 1 mild allergy with slight irritation.

The present invention also provides the following control groups 2-4 and examples 1-5 of the present invention for effect control tests.

Control group 2: the test product of control group 2 was prepared according to the formulation and procedure of example 1 of patent No. CN201610787973.3 entitled "striae gravidarum prevention composition and striae gravidarum cream and preparation method thereof", and the preparation conditions were strictly controlled.

And a control group 3, namely, the essence cream for preventing the generation of the stretch marks and the preparation method thereof are prepared according to the formula and the steps of the example 1 in the patent No. 201910311710.9, and the conditions in the technical scheme are strictly controlled to obtain a test finished product of the control group 3.

Control group 4: the conventional striae gravidarum repair cream is purchased from the market and is qualified as a box.

Effect test: an effect comparison test was performed on the stretch mark repair creams of the above examples 1 to 5 and the control groups 2 to 4.

The experimental control conditions and procedures were as follows:

400 female volunteers in the early gestation stage, aged 20-45 years, were selected at the same time in the same area and randomly divided into 8 groups of 50 individuals each. In the early pregnancy, the abdomen or the legs of each volunteer have no striae gravidarum or only slight striae gravidarum, but no other obvious skin diseases, so the health state is good. 8 groups of volunteers applied to the abdomen, chest and thigh correspondingly with the test finished products in examples 1-5 and control groups 2-4 respectively and lightly pressed until absorption, 1-2 times per day, the volunteers fed back the striae gravidarum condition and use feeling every day, and each group of volunteers used the corresponding test product as the only striae gravidarum repair product for the time from the early gestation period to two weeks before the expected birth, the use of the test product was stopped two weeks before the expected birth, but the striae gravidarum condition was fed back two weeks after the birth. The conditions of the use feedback of the volunteers are recorded and the data are summarized, and the obtained test results are shown in the attached figure 1 and the table 2.

Table 2: results of the test of feeling of use of examples and control group

As is apparent from the comparison result of the histogram of the striae gravidarum incidence rates of the examples 1 to 5 and the control groups 2 to 4 in fig. 1, compared with the striae gravidarum repair cream obtained by the control group 2 and the control group 3 according to the technical schemes of other invention patents and conventional products in the market, the striae gravidarum repair cream obtained in the examples 1 to 5 of the present invention can significantly reduce the incidence rate of striae gravidarum, so that the incidence rate of striae gravidarum is reduced to below 40%, and has a prominent effect on preventing and repairing striae gravidarum.

Particularly, the striae gravidarum repair cream obtained in example 3 has the striae gravidarum incidence rate reduced to below 30%, is the best implementation technical scheme obtained by long-term research of the inventor, can effectively prevent the striae gravidarum, and is safe, mild and free of irritation.

As is apparent from the results of comparing the use feelings of the examples 1 to 5 and the control groups 2 to 4 in the above Table 2, the stretch mark repair creams obtained in the examples 1 to 5 of the present invention are more comfortable to use and hardly cause greasy feeling, compared with the stretch mark repair creams of the control group 2 and the control group 3, and the conventional products on the market. The comfort level of the control groups 2 to 4 was not as high as that of the present invention, and particularly, the conventional products on the market produced greasy feeling to some users, which made users feel uncomfortable, easily produced rejection, and difficult to use consistently. In addition, no allergic condition appeared in the present example, while the control group 2 and the control group 4 both had slight allergic condition, and had certain irritation.

The invention selects the best component collocation through long-term research and continuous tests, and obtains the best component proportion and the rule of component interaction effect exertion through continuous trial and test and experience summarized in failure. For example, the control group 1 was one of many failed solutions, and although it had some effect, it also had some irritation. Further intensive studies and a summary of the experience have resulted in the control of the proportions of the components and the mass ratios of the components that avoid the irritation associated with the interaction between the components and exert the best results. When the mass percentage ratio of the olive fruit oil to the argania spinosa kernel oil is 1: (1.7-2.1), the ratio of the mass percent of the calcium sodium phosphosilicate to the mass percent of the centella asiatica extract is 1: (2.6-2.7), the whole efficacy and the viscosity and the quality of the repair cream can be well promoted, the use is more comfortable, the proportion of other components is controlled, and the whole excellent effect is shown. Meanwhile, the preparation method is continuously tried, and the optimal control condition is selected to prepare the stretch mark repair cream with the optimal effect.

The above description is only for the purpose of illustrating the embodiments of the present invention and not for the purpose of limiting the same, and equivalent modifications and variations of the embodiments of the present invention will be apparent to those skilled in the art without departing from the overall spirit of the invention.

Claims

1. The striae gravidarum repair cream is characterized in that: comprises a component A, a component B and a component C; wherein the component A comprises the following substances in percentage by mass: 0.05 to 0.3 percent of xanthan gum, 5.0 to 8.0 percent of glycerol, 1.0 to 2.0 percent of hexanediol, 2.0 to 3.0 percent of pentanediol and 8.0 to 13.3 percent of humectant;

the component C comprises the following substances in percentage by mass: 0.5-3.0% of hydrolyzed collagen, 3.0-8.0% of calcium phosphosilicate and 0.5-3.0% of centella asiatica (CENTELLA ASIATICA) extract; the component D comprises the following substances in percentage by mass: 0.1 to 0.5 percent of purslane extract, 0.05 to 0.1 percent of folic acid and 0.1 to 0.3 percent of aloe extract;

the balance being deionized water.

2. The stretch mark repair cream according to claim 1, wherein: the component A comprises the following substances in percentage by mass: 0.05 to 0.26 percent of xanthan gum, 5.5 to 8.0 percent of glycerol, 1.3 to 1.8 percent of hexanediol, 2.1 to 3.0 percent of pentanediol and 8.0 to 13.2 percent of humectant;

the balance being deionized water.

3. The stretch mark repair cream according to claim 2, wherein: the component A comprises the following substances in percentage by mass: 0.05% of xanthan gum, 8.0% of glycerol, 1.5% of hexanediol, 3.0% of pentanediol and 10.05% of humectant;

the balance of deionized water;

the calcium sodium phosphosilicate is a nano-grade material, and the particle size of the material is 5-10 microns.

4. The stretch mark repair cream as claimed in claim 1, wherein: the humectant comprises 6.0-8.0% of butanediol, 2.0-5.0% of urea and 0.05-0.3% of sodium hyaluronate.

5. The stretch mark repair cream according to claim 1, wherein: the humectant comprises 1.0-2.0% of betaine, 0.5-1.5% of trehalose, 260.5-1.0% of polyglycerol ether, 100.5-1.0% of polyglycerol and 4004.0-8.0% of polyvinyl alcohol.

6. The stretch mark repair cream according to claim 1, wherein: the mass percentage ratio of the olive (Olea EUROPAEA) fruit oil to the ARGANIA SPINOSA (ARGANIA SPINOSA) kernel oil is 1: (1.7-2.1).

7. The stretch mark repair cream according to claim 1, wherein: the ratio of the mass percent of the calcium sodium phosphosilicate to the mass percent of the centella asiatica (CENTELLA ASIATICA) extract is 1: (2.6-2.7).

8. The stretch mark repair cream according to claim 1, wherein: the hydrolyzed collagen is derived from fish scales, cod skin and tendon tissue of cattle, and is prepared by the following steps: respectively pretreating fish scales, cod skin and tendon tissue of cattle, and mixing the pretreated fish scales, cod skin and tendon tissue of cattle in a ratio of 1: and 3:7.5, mixing uniformly, extracting by subcritical fluid, adding a compound enzyme of collagenase, trypsin, papain and decarboxylase for enzymolysis, wherein the nominal activity of the compound enzyme is 1.7-1.9AU-N/g, filtering by an ultrafiltration membrane with the molecular weight cutoff of 6-15kDa, purifying and concentrating by an RO reverse osmosis membrane, and drying under a microwave vacuum low-temperature environment to obtain the hydrolyzed collagen.

9. The method for preparing a stretch mark repair cream according to any one of claims 1 to 8, wherein: the method comprises the following steps:

10. The preparation method of the stretch mark repair cream according to claim 9, wherein the preparation method comprises the following steps: when vacuum defoaming is carried out in the step 3, cold water spraying is adopted for rapid cooling, and the cold water spraying is stopped after the temperature is reduced to 55 ℃, and the temperature is slowly reduced;