CN111617141A

CN111617141A - Traditional Chinese medicine composition spray for treating lobular hyperplasia and preparation method

Info

Publication number: CN111617141A
Application number: CN201910111245.4A
Authority: CN
Inventors: 张天亮
Original assignee: Individual
Current assignee: Individual
Priority date: 2019-02-12
Filing date: 2019-02-12
Publication date: 2020-09-04

Abstract

The invention provides a traditional Chinese medicine composition spray for treating lobular hyperplasia, which is characterized by comprising the following traditional Chinese medicine raw materials by weight: 1-5 g of oyster, 165 g of 135-inch luffa, 7-13 g of ternate buttercup root, 165 g of 135-inch snakegourd fruit, 5-11 g of nux vomica, 3-9 g of stiff silkworm, 1-5 g of kelp, 9-15 g of selfheal, 175 g of 145-inch old and fresh luffa and 500 g of white spirit. The preparation method comprises placing Prunellae Spica in a sealed glass container containing 500 g Chinese liquor in summer, and soaking in cool and dry place for 40 days; simultaneously putting the rest Chinese medicinal materials into the soaked medicated liquor, and taking out after soaking for 40 days; the filtrate was separated from the solid-liquid mixture obtained above and charged into a watering can with a shower head. The traditional Chinese medicine composition spray has the effects of dredging, relieving pain, promoting blood circulation and removing blood stasis aiming at lobular hyperplasia; and has the functions of resolving knots and dispersing silt; can be used for effectively relieving subcutaneous nodule, lipoma, and fibroma, and also has anticancer effect.

Description

Traditional Chinese medicine composition spray for treating lobular hyperplasia and preparation method

Technical Field

The invention relates to the field of medicine formulas, in particular to a traditional Chinese medicine composition spray for treating lobular hyperplasia and a preparation method thereof.

Background

Lobular hyperplasia belongs to the category of hyperplasia of mammary glands, and is a benign proliferative disease of mammary tissue. Neither inflammation nor tumor, due to hormonal cycling in women. Hyperplasia of mammary duct epithelial cells and fibrous tissue in the breast can be caused by excessive levels of estrogen secreted by the ovaries, insufficient luteal progestagen, or an uncoordinated secretion of both. Normally, the acinus, duct and fibrous tissue of each woman entering the breast of puberty undergoes a process of tissue alteration of proliferation and recovery during each menstrual cycle. Due to the change, before each menstruation, each woman may have a slight or heavy distending pain in one or both breasts, and the distending pain naturally disappears after menstruation, which is a normal physiological phenomenon without hindering life, learning and work. However, when the body is under the action of some stress factors (such as over-tension in work, over-excited mood, old age without marriage, no lactation after delivery and some chronic diseases), the hyperplasia of mammary glands which should be restored by the breasts can not be restored or can not be restored completely, and hyperplasia of mammary glands is formed after a long time, which is manifested as three symptoms and signs of thickened breast lobes and nodular granules, breast distending pain, nipple overflow and the like.

Lobular hyperplasia of mammary gland (stage i hyperplasia of mammary glands): for medical diagnosis, the early hyperplasia of mammary glands mostly occurs in 25-35 years old, the symptoms are mild, and the mammary gland hyperplasia belongs to the stage I of mammary glands. The prevalence rate of hyperplasia of mammary glands is more than 70%, which is not paid attention to and is not treated actively. If the treatment is not carried out in time, the mammary gland is easy to become cancerous, part of mammary gland hyperplasia is lingering for a long time, and benign tumor or malignant lesion of the mammary gland can be generated.

At present, the treatment of the disease is mainly based on drug therapy, western medicines take hormone as a preferred medicine, symptoms are relieved by regulating endocrine, and medicines for symptomatic treatment are supplemented according to the symptoms. According to the traditional Chinese medicine, the Chong and ren meridians are the sea of qi and blood, the ascending meridians are the breast, the descending meridians are the channels, once worry damages the spleen and worry damages the liver, the qi stagnation of the channels and the disorder of the Chong and ren meridians can occur as a result, and the breast diseases can occur.

Chinese patent (No. CN 102225123B) discloses a Chinese medicament for treating hyperplasia of mammary glands, which is prepared by decocting the following raw material medicaments in part by weight in water into decoction: 9-12 parts of muskroot-like semiaquilegia root, 10-20 parts of coltsfoot-flower, 9-12 parts of wild chrysanthemum flower, 10-20 parts of honeysuckle flower, 20-40 parts of dandelion, 9-12 parts of orange leaf and 6-10 parts of green plum blossom. Chinese patent (No. CN 101564483B) discloses a liver soothing granule for treating hyperplasia of mammary glands, which comprises the following raw materials in parts by weight: 200-250 parts of angelica, 133-150 parts of white peony root, 133-150 parts of bighead atractylodes rhizome, 67-100 parts of vinegar-processed rhizoma cyperi, 93-140 parts of radix bupleuri, 133-150 parts of poria cocos, 67-100 parts of mint, 40-60 parts of cape jasmine, 40-60 parts of moutan bark and 94-120 parts of liquorice. Therefore, the traditional Chinese medicine has a good curative effect on treating the lobular hyperplasia of mammary glands, but the existing traditional Chinese medicine is an oral medicine, has a poor effect on treating the lobular hyperplasia of mammary glands as compared with a spray, and causes additional burden on the body of a patient.

Disclosure of Invention

Aiming at the defects in the prior art, the invention aims to provide the traditional Chinese medicine composition spray for treating the lobular hyperplasia, which is convenient to carry and has an obvious effect. The invention also aims to provide a preparation method of the spray.

In order to achieve the purpose, the technical scheme of the invention is as follows:

a traditional Chinese medicine composition spray for treating lobular hyperplasia comprises the following traditional Chinese medicine raw materials by weight: 1-5 g of oyster, 165 g of 135-inch luffa, 7-13 g of ternate buttercup root, 165 g of 135-inch snakegourd fruit, 5-11 g of nux vomica, 3-9 g of stiff silkworm, 1-5 g of kelp, 9-15 g of selfheal, 175 g of 145-inch old and fresh luffa and 500 g of white spirit.

The preferred scheme of the traditional Chinese medicine composition spray is as follows: comprises the following Chinese medicinal raw materials by weight: 2-4 g of oyster, 160 g of 140-160 g of sarcandra glauca, 8-12 g of radix ranunculi ternati, 160 g of 140-140 g of snakegourd fruit, 6-10 g of nux vomica, 4-8 g of stiff silkworm, 2-4 g of kelp, 10-14 g of selfheal, 150-170 g of old and fresh luffa and 500 g of white spirit.

The better preferable scheme of the traditional Chinese medicine composition spray is as follows: comprises the following Chinese medicinal raw materials by weight: 3 g of oyster, 150 g of sarcandra, 10 g of ternate buttercup root, 150 g of snakegourd fruit, 8 g of nux vomica, 6 g of stiff silkworm, 3 g of kelp, 12 g of selfheal, 160 g of old and fresh towel gourd and 500 g of white spirit.

The preparation method of any traditional Chinese medicine composition spray preferably comprises the following steps:

(1) putting the selfheal into a closed glass container filled with 500 g of white spirit in a summer single season, and putting the container in a cool and dry place to soak for 40 days;

(2) simultaneously putting the rest Chinese medicinal materials into the soaked medicated liquor, and taking out after soaking for 40 days;

(3) the filtrate was separated from the solid-liquid mixture obtained above and charged into a watering can with a shower head.

The preferred scheme is as follows: and (4) separating the solid-liquid mixture in the step (3), extracting for 3 times by adopting ultrasonic extraction, wherein the extraction time is set to be 20-25 min each time.

Another preferred solution is: separating the solid-liquid mixture in the step (3), performing primary centrifugation for 25-35 min by adopting a centrifuge at the rotating speed of 1000-1500 rpm, and collecting supernatant of the primary centrifugation; and (4) carrying out secondary sedimentation and centrifugation on the collected supernatant in the same way, and collecting the supernatant obtained by the secondary centrifugation.

The preferred scheme is as follows: scales are arranged on the outer wall of the sprinkling can used in the step (3), so that the using amount is convenient to control.

The using method comprises the following steps: in order to achieve the best treatment effect, when the traditional Chinese medicine composition spray is used, hands and breasts are cleaned by warm water, and the traditional Chinese medicine composition spray is sprayed on the breasts twice in the morning and evening, and 3-4 g of the traditional Chinese medicine composition spray is sprayed every day.

The pharmacological effects of the raw materials are respectively as follows:

(1) oyster shell: [ PROPERTIES AND FLAVOUR ] slightly cold and salty. [ GUIJING ] enters liver, gallbladder and kidney meridians. [ EFFECT ] calming the liver and suppressing yang hyperactivity; heavy-weight tranquilizing; softening and resolving hard mass; astringe and induce astringency. Dominant vertigo tinnitus; palpitation and insomnia; scrofula and goiter; abdominal mass; spontaneous sweating and night sweat; spermatorrhea; (ii) metrorrhagia and metrostaxis; with leucorrhea.

(2) Eight-shuttle melon (loofah): [ PROPERTIES AND FLAVOUR ] PING, sweet. [ GUIJING ] enters stomach meridian, lung meridian and liver meridian. [ EFFECT ] can dredge collaterals, promote blood circulation, and dispel pathogenic wind. Can be used for treating arthralgia and spasm, distending pain in chest and hypochondrium, and galactostasis.

(3) Radix ranunculi ternati: [ PROPERTIES AND FLAVOUR ] WEN, pungent and sweet. [ GUIJING ] enters lung and liver meridians. [ EFFECT ] detoxication; resolve phlegm and dissipate nodulation. Mainly treats scrofula; tuberculosis; pharyngitis; furuncle; snake bite; malaria; migraine headache; toothache.

(4) And (3) snakegourd fruit: [ PROPERTIES AND WESTERN ] is cold, pungent and bitter. [ GUIJING ] enters stomach meridian, lung meridian, and large intestine meridian. [ EFFECT ] clear heat and remove phlegm, relieve chest stuffiness and dissipate nodulation, moisten intestines. Can be used for treating cough due to lung heat, turbid phlegm, yellow and thick phlegm, thoracic obstruction, cardialgia, acute mastitis, pulmonary abscess, and intestinal abscess with swelling and pain. Effect on the cardiovascular system: dilating coronary artery; anti-myocardial ischemia; dilating the microvasculature and improving microcirculation; inhibiting platelet aggregation; hypoxia tolerance; antiarrhythmic, expectorant, purgative, and anticancer effects.

(5) Nux vomica: [ PROPERTIES AND WESTERN ] is warm and bitter. [ GUIJING ] enters spleen and liver meridians. [ EFFECT ] can dredge collaterals, alleviate pain, dissipate stagnation and relieve swelling. Can be used for treating rheumatism, numbness, paralysis, traumatic injury, carbuncle, cellulitis, and swelling and pain; sequela of poliomyelitis, rheumatoid arthralgia. Can be used for treating numbness of limbs, paralysis, anorexia, lump, carbuncle, sore, toxic swelling, and sore throat.

(6) Stiff silkworm: [ PROPERTIES AND FLAVOUR ] PING, pungent and salty. [ GUIJING ] enters stomach meridian, lung meridian and liver meridian. [ EFFECT ] dispel pathogenic wind, arrest convulsion, resolve phlegm and dissipate nodulation. Used for treating crooked liver wind with phlegm, convulsive epilepsy and convulsion, infantile acute convulsion, tetanus, apoplexy, wind-heat headache, conjunctival congestion and pharyngalgia, rubella pruritus, Yimei mumps, wind extinguishing and spasm relieving, wind dispelling and pain relieving, phlegm eliminating and stagnation resolving; it can also be used for treating skin pruritus, submandibular lymphadenitis, and facial paralysis.

(7) Kelp: [ PROPERTIES AND FLAVOUR ] Cold and salty. [ GUIJING ] enters liver, stomach and kidney meridians. [ EFFECT ] the product has effects of softening hard masses, resolving phlegm, inducing diuresis and clearing heat. Treating goiter, tumor, tuberculosis, hernia, edema and tinea pedis. Resisting oxidation and preventing cancer.

(8) Selfheal: [ PROPERTIES AND WESTERN ] is cold, bitter and pungent. [ GUIJING ] enters gallbladder and liver meridian. [ EFFECT ] removing liver heat and improving eyesight; dispersing accumulation of pathogen and removing toxic substance. Mainly treats photophobia of eyes; pain in the eyeball; headache and dizziness; tinnitus; scrofula; goiter and tumor; acute mastitis; mumps; carbuncle and furuncle; acute and chronic hepatitis; hypertension.

(9) Old and fresh towel gourd: [ PROPERTIES AND FLAVOUR ] Cool and medicinal. [ GUIJING ] enters stomach meridian and liver meridian. [ EFFECTIVE ACTION ] can clear away heat, resolve phlegm, cool blood and remove toxicity. It is indicated for fever with polydipsia, phlegm dyspnea, cough, intestinal wind, hemorrhoid, metrorrhagia, bloody stranguria, furuncle, galactostasis, and carbuncle.

(10) White spirit: [ PROPERTIES AND FLAVOUR ] pungent, sweet and bitter. [ EFFECT ] can promote blood circulation; the efficacy of the medicine is exerted. Is mainly used for treating wind-cold arthralgia; spasm and urgency of tendons and vessels; chest stuffiness; heartburn; abdominal cold pain.

Has the advantages that: the traditional Chinese medicine composition spray has the effects of dredging, relieving pain, promoting blood circulation and removing blood stasis aiming at lobular hyperplasia; and has the functions of resolving knots and dispersing silt; can be used for effectively relieving subcutaneous nodule, lipoma, and fibroma, and also has anticancer effect.

Detailed Description

The invention is illustrated below with reference to specific examples. It will be understood by those skilled in the art that these examples are for illustrative purposes only and are not intended to limit the scope of the present invention in any way.

Example 1

A traditional Chinese medicine composition spray for treating lobular hyperplasia is prepared from the following main raw materials by weight: 3 g of oyster, 150 g of sarcandra, 10 g of ternate buttercup root, 150 g of snakegourd fruit, 8 g of nux vomica, 6 g of stiff silkworm, 3 g of kelp, 12 g of selfheal, 160 g of old and fresh towel gourd and 500 g of white spirit.

The preparation method of the traditional Chinese medicine composition spray comprises the following steps:

(3) extracting the obtained solid-liquid mixture by ultrasonic wave for 3 times, wherein the extraction time is set to be 25min each time; the filtrate was separated and charged into a watering can with a shower head and graduations.

Example 2

A traditional Chinese medicine composition spray for treating lobular hyperplasia is prepared from the following main raw materials by weight: 4 g of oyster, 160 g of sarcandra, 12 g of ternate buttercup root, 160 g of snakegourd fruit, 10 g of nux vomica, 8 g of stiff silkworm, 4 g of kelp, 14 g of selfheal, 170 g of old and fresh towel gourd and 500 g of white spirit.

(3) centrifuging the obtained solid-liquid mixture for the first time for 35min at the rotating speed of 1500 rpm by adopting a centrifuge, and collecting supernatant of the first centrifugation; and (4) performing secondary sedimentation and centrifugation on the collected supernatant in the same way, collecting the supernatant subjected to the secondary centrifugation, and filling the supernatant into a spray can with a spray head and scales.

Example 3

A traditional Chinese medicine composition spray for treating lobular hyperplasia is prepared from the following main raw materials by weight: 2 g of oyster, 140 g of sarcandra, 8 g of ternate buttercup root, 140 g of snakegourd fruit, 6 g of nux vomica, 4 g of stiff silkworm, 2 g of kelp, 10 g of selfheal, 150 g of old and fresh towel gourd and 500 g of white spirit.

(3) extracting the obtained solid-liquid mixture by ultrasonic wave for 3 times, wherein the extraction time is set to be 20min each time; the filtrate was separated and charged into a watering can with a shower head and graduations.

Example 4

A traditional Chinese medicine composition spray for treating lobular hyperplasia is prepared from the following main raw materials by weight: 5 g of oyster, 165 g of sarcandra, 13 g of ternate buttercup root, 165 g of snakegourd fruit, 11 g of nux vomica, 9 g of stiff silkworm, 5 g of kelp, 15 g of selfheal, 175 g of old and fresh towel gourd and 500 g of white spirit.

(3) centrifuging the obtained solid-liquid mixture for the first time for 25min by adopting a centrifuge at the rotating speed of 1000 revolutions per minute, and collecting supernatant of the first centrifugation; and (4) performing secondary sedimentation and centrifugation on the collected supernatant in the same way, collecting the supernatant subjected to the secondary centrifugation, and filling the supernatant into a spray can with a spray head and scales.

Example 5

A traditional Chinese medicine composition spray for treating lobular hyperplasia is prepared from the following main raw materials by weight: oyster 1 g, 135 g of sarcandra, 7 g of radix ranunculi ternati, 135 g of snakegourd fruit, 5 g of nux vomica, 3 g of stiff silkworm, 1 g of kelp, 9 g of selfheal, 145 g of old and fresh towel gourd and 500 g of white spirit.

In a typical case, you in someone, woman, 29 years old. When the patient is treated at 2010, the breasts of the patient are full, and small lumps are found in the breasts one by one, with stabbing pain and distending pain in the two hypochondriac regions. It is considered to be hyperplasia of mammary glands. Spraying the traditional Chinese medicine composition spray obtained in the embodiment 1 of the invention for 2 treatment courses, softening pimples and relieving pain, advising the use of the spray for 1 treatment course, and completely eliminating all symptoms; after recovery, the medicine is used and consolidated for 1 course of treatment, and no relapse occurs until the medicine is stopped.

In a typical case, a certain woman in the second sun is 47 years old, and the patient is diagnosed in 2013, the breast masses on the two sides of the patient have more than one year, the left side of each breast mass is found to be soybean-type pain, and the breast lobular hyperplasia is detected by a hospital in the center of the market, and the operation treatment is proposed, and the patient does not agree with the operation due to fear and requires conservative treatment, wherein the Chinese medicinal composition spray obtained in the embodiment 2 of the invention is sprayed for 1 course of treatment, the mass is softened and reduced, the pain is relieved, and the patient is advised to use the Chinese medicinal composition spray for 2 courses of treatment, and the pain of the mass is completely disappeared; after recovery, the medicine is used for 2 courses of treatment, and prevention is carried out after two years, and no recurrence is caused.

The typical case is three, female, aged 38, and the patient is seen in 2015, and the patient self-states: 3-5 days before menstruation comes each time, the breast is full of pain when menstruation comes, the breast is full of pain is relieved when menstruation comes, but the pain does not disappear, the pain disappears after 3-5 days after menstruation does not come, sometimes, the breast is full of pain when the life is irregular, and the examination in hospitals is confirmed as follows: the invention discloses a Chinese medicinal composition spray for treating hyperplasia of mammary glands, which is used after 5 days before menstruation. After the traditional Chinese medicine composition spray obtained in the embodiment 3 of the invention is used, the pain in the breast before menstruation is relieved, the traditional Chinese medicine composition spray has the effect of being used for 2 treatment courses continuously until the pain in the breast before the next menstruation disappears, the patient can be cured from the pain, the traditional Chinese medicine composition spray is used for 1 treatment course after the cure, and the recurrence is avoided until the medicine is stopped.

Clinical observations

In order to verify whether the traditional Chinese medicine composition spray (example 1) has curative effect on the treatment of the breast lobular hyperplasia, the average age of 240 breast lobular hyperplasia patients is 38 years.

The groups were randomly divided into experimental and control groups. The patient's physical condition was recorded the day before the experiment and the patient's physical symptoms were reviewed daily to ensure that the experimental and control groups were substantially identical. When the traditional Chinese medicine composition spray obtained in the embodiment 1 of the product is used in an experimental group every day, hands and breasts are cleaned by warm water, the traditional Chinese medicine composition spray is smeared on the breasts twice in the morning and at night, 3-4 g of the traditional Chinese medicine composition spray needs to be sprayed every day, and one month is a treatment course. The body conditions of patients are checked every day and recorded when the experimental group uses/takes the medicines (such as Xiaoyao powder, Xiaojin pills, nodules of breast and lump of breast and other medicines for treating the lobular hyperplasia of the breast) for treating the lobular hyperplasia of the breast.

Criteria for determination

And (3) curing: the discomfort symptom disappears, and the effect is as follows: the discomfort symptoms substantially disappeared, and were ineffective: no change in symptoms of discomfort. The results are given in the following table:

group of	Classes of drugs	Number of cases	Number of effective persons	High efficiency	The number of people cured	Cure rate
							Control group	Oral medicine	120	104	86.7%	89	74.2%
Experimental group	Example 1	120	113	94.2%	108	90.0%

Clinical tests prove that the Chinese medicinal composition spray has the effective rate of 94.2 percent and the cure rate of 90.0 percent on treating the lobular hyperplasia of mammary glands, has the effective rate of 7.5 percent and the cure rate of 15.8 percent higher than that of other orally taken medicaments for treating the lobular hyperplasia of mammary glands, can thoroughly remove the disease roots and ensures that patients are really cured.

And (3) analyzing the curative effect: in an experimental group (the traditional Chinese medicine composition spray in the embodiment 1) when the traditional Chinese medicine composition is used for 12 days, most patients feel obviously relieved, the affected parts feel obviously improved, the emotion of the patients is improved, the patients are basically cured after the traditional Chinese medicine composition is used for 28 days, the medicine is stopped for a period of time, the repeated use is not caused, and the disease condition is well controlled.

Claims

1. A traditional Chinese medicine composition spray for treating lobular hyperplasia is characterized by comprising the following traditional Chinese medicine raw materials by weight: 1-5 g of oyster, 165 g of 135-inch luffa, 7-13 g of ternate buttercup root, 165 g of 135-inch snakegourd fruit, 5-11 g of nux vomica, 3-9 g of stiff silkworm, 1-5 g of kelp, 9-15 g of selfheal, 175 g of 145-inch old and fresh luffa and 500 g of white spirit.

2. The traditional Chinese medicine composition spray for treating lobular hyperplasia according to claim 1, which is characterized by comprising the following traditional Chinese medicine raw materials by weight: 2-4 g of oyster, 160 g of 140-160 g of sarcandra glauca, 8-12 g of radix ranunculi ternati, 160 g of 140-140 g of snakegourd fruit, 6-10 g of nux vomica, 4-8 g of stiff silkworm, 2-4 g of kelp, 10-14 g of selfheal, 150-170 g of old and fresh luffa and 500 g of white spirit.

3. The traditional Chinese medicine composition spray for treating lobular hyperplasia according to claim 1, which is characterized by comprising the following traditional Chinese medicine raw materials by weight: 3 g of oyster, 150 g of sarcandra, 10 g of ternate buttercup root, 150 g of snakegourd fruit, 8 g of nux vomica, 6 g of stiff silkworm, 3 g of kelp, 12 g of selfheal, 160 g of old and fresh towel gourd and 500 g of white spirit.

4. A preparation method of a traditional Chinese medicine composition spray for treating lobular hyperplasia is characterized by comprising the following steps:

5. The preparation method of the Chinese medicinal composition spray for treating lobular hyperplasia according to claim 4, wherein the solid-liquid mixture is separated in the step (3), ultrasonic extraction is adopted, the extraction is performed for 3 times, and the extraction time is set to be 20-25 min each time.

6. The preparation method of the traditional Chinese medicine composition spray for treating lobular hyperplasia according to claim 4, wherein the solid-liquid mixture is separated in the step (3), a centrifuge is adopted, the first centrifugation is carried out for 25-35 min at the rotation speed of 1000-1500 rpm, and supernatant of the first centrifugation is collected; and (4) carrying out secondary sedimentation and centrifugation on the collected supernatant in the same way, and collecting the supernatant obtained by the secondary centrifugation.

7. The method for preparing a Chinese medicinal composition spray for treating lobular hyperplasia according to claim 4, wherein the outer wall of the spray can used in step (3) is provided with scales so as to control the usage amount.