CN1116038C - Exterior-applied liquid medicine for treating acne - Google Patents

Abstract

The present invention relates to an externally applied physic liquor for treating common acne, which is prepared from chloromycetin, metronidazole, stilbestrol, vitamin B6, dimethyl sulfoxide, ethanol, etc. The present invention achieves full effects of antisepsis, inflammation relief, sex hormone balance regulation and sebaceous gland secretion inhibition by adopting the combination of medicines with the functions of resisting bacterium and eumycete and antiandrogen medicines and the strong permeability of a penetrating agent. The present invention has an outstanding curative effect, the cure rate is as high as 93.44%, and the total effective rate is 100%. The present invention can cure intractable acne conglobata, and also has the functions of tendering and whitening skin and beautifying face. The physic liquor has the advantages of nontoxicity, few adverse reactions, convenience for external application, easy preparation and low cost.

Description

A kind of external medicinal liquid for the treatment of acne

The present invention relates to a kind of medicinal liquid for the treatment of acne vulgaris, particularly can eliminate the medicinal liquid of acne by spreading upon the human body skin surface.

Acne is a kind of commonly encountered diseases and frequently-occurring disease, generally occurs in adolescence, is commonly called as " comedo " again, betides the abundant position of sebaceous gland.In face, pathogenic factor is not clear fully as yet at present, it is generally acknowledged following several reason especially, 1. two gonadal hormone imbalances in the adolescence body, mainly be that the androgen level increases, under the androgen effect, the sebaceous hyperplasia hypertrophy, sebum secretion increases, hair follicle sebum conduit hyperkeratosis causes the sebum stasis of blood long-pending, has formed acne, and the formation anaerobic environment, for the acneform bacillus provides good breeding condition; 2. microorganism that exists in the sebum hair follicle such as corynebacterium acnes, Staphylococcus albus, oval Kang Blighted pityrosporion ovale all can decompose sebum, produce free fatty hair follicle stimulating causing inflammation property pimple and abscess, but are most important reason with the corynebacterium acnes; 3. immune dysfunction, its performance divides some again.(1) corynebacterium acnes produces antibody in patient's body, and activating complement causes the inflammation in the pilosebaceous unit pipe, and the bacterial immune reaction of corynebacterium acnes mediation may increase the weight of the inflammation of acne; (2) detected immune complex deposit around skin damaged skin pilosebaceous unit, this may be that acne propanoic acid village bacterium stimulates body as antigenic substance, causes that body produces whole body or partial cell and humoral immune reaction; 4. food factor: too much cause as fatty in the food or saccharide; 5. life anxiety or emotion cause.Clinical symptoms: the general normal face that betides of primary disease, breast, the back, from the beginning of being hoary hair's acne or the blackhead that is positioned at follicular orifice, and can extrude the translucent fat bolt of yellow-white, the red pimple of inflammatory can appear later on, born of the same parents' skin ulcer, tuberosity, abscess, skin lesion such as cyst, after disappearing, skin lesion can leave temporary pigmentation or pitting concavity cicatrix, because especially it pays attention to appearance in adolescence, very worried when producing acne on the face, the influence that has work and study, even be ashamed of seeing the people, in order to treat this disease, hospital also only uses some antibiotic medicine at present, therapeutic effect is bad, and beauty salon is set up in the city that has, and carries out external with some Chinese medicines or organic drug, but also only not serious acne are played some effects, spend 1-2 days and can recur again,, treat " cardiopathia " of this adolescence with better effect so many dermatologists are also studied new drug at present constantly.

Some medical journals and patent documentation all disclose the oral medicine or the medicine for external use of some treatment acnes in recent years, disclose the compositions of a kind of pH less than 7 treatment acne as Chinese patent 93101631, and it comprises Oxybenzene formyl, clindamycin or fat; Another part Chinese patent 93110175 discloses a kind of alcoholic solution for the treatment of acne, and it contains sodium salicylate, chloromycetin, vitamin B6; People such as U.S. AM Kao Lesi have also applied for patent of invention in April 19 nineteen ninety-five No. 95193152 to Patent Office of the People's Republic of China, and it is a kind of chemical compound of being made up of benzoyl peroxide, wetting agent, water of preventing and treating acne.

The deficiency that exists in the medicine of above-mentioned disclosed treatment acne is the pharmaceutical compositions complexity that has, the manufacturing cost height, the therapeutic effect that has is also not obvious, and the patient's refractory when infected is treated to acne, side reaction is arranged, not high to the universality that the people of different skin character cures.

The purpose of this invention is to provide a kind of good effect, cure rate height, side reaction is few, cost is low, be easy to produce, the external medicinal liquid of the convenient treatment acne vulgaris that uses.

The inventor is in medical practice, particularly in being engaged in the work of dermatosis clinical treatment, the cause of disease of acne and the medicine of treatment acne were carried out many researchs and exploration, after continuous summary and careful observation, some medicines have been found, and through repeatedly screening, comprise animal experiment and own skin test, assembly goes out the chemical compound of following treatment acne, and concrete composition and content are as follows: metronidazole 100-250 gram, chloromycetin 50-100 gram, diethylstilbestrol 0.5-1.0 gram, vitamin B6 2-10 gram, 1000 milliliters of 50-70% (weight) ethanol, dimethyl sulfoxide 200-800 milliliter.

The compound method of the present composition is: with metronidazole, chlorine syphilis, diethylstilbestrol, vitamin B6 pulverize, join in the alcoholic solution, behind the mix homogeneously, add dimethyl sulfoxide again, stir, can use, before reusing after placing, should shake, make it form emulsion, the adhesional wetting of reuse cotton swab, smear the affected part, be coated with 1-2 every day, to slight patients with acne, adhere to coating every day, 2 thoughtful one month, it was bright and clean to recover skin, removes acne; To medium or severe acne patient, used continuously 2-3 month, also can fully recover, to the pachylosis person, also can make it attenuate, tenderize after the use.

Pharmacological action of the present invention is: chloromycetin is broad-spectrum antibiotic, and antibacterial action is strong, and aerobe and the anaerobe that causes primary disease all had stronger antibiotic vigor, mainly brings into play curative effect because of it can suppress antibacterial lipase.Metronidazole is a nitroimidazole compound, anaerobe dna break or blocking-up is transcribed duplicate, and surperficial bacterial parasite is killed and inhibitory action.Diethylstilbestrol: be androgen antagonist, the androgen antagonist external preparation mostly is the inhibitor or the antagonist of androgen receptor, and high specificity is arranged; Side effect is little, can suppress the secretion of glandular integumentaria effectively, and the estrogen external can suppress the sebaceous gland function, reduces the secretion of skin, or makes the glandular integumentaria atrophy.Can also make skin moisturizing, elasticity increases, and pore diminishes, and skinfold shoals, and reduces the young stricture of vagina of skin, and the skin moisturizing performance is better, reaches the purpose of skin attractive in appearance.Vitamin B6 participates in the metabolism of aminoacid and ester fat, suppresses the secretion of sebaceous gland.Dimethyl sulfoxide is good solvent, and dissolubility is strong, and permeability is strong, has hypotoxicity, the slight stimulation, and antiinflammatory is arranged, and is antipruritic, presses down various bacteria and the fungus effect of killing.

The present invention compared with prior art, outstanding substantive distinguishing features and the obvious improvement that have are:

1. evident in efficacy, to various types of acnes, the effective percentage of treatment is 100%, can also be to nodular type, the effective therapeutic effect of acne conglobata.

2. cost is low, and raw material sources are wide.

3. need not take orally, only need the outside to smear, can cure the disease, use very convenient.

4. also has the effect of antiinflammatory, antipruritic, kill bacteria when using.

5. the patient to oiliness, neutrality, dry skin can both be suitable for.

Below be preparation embodiment of the present invention:

Embodiment one: metronidazole 100 grams, chloromycetin 50 grams, diethylstilbestrol 0.5 gram, vitamin B6 2 grams, above-mentioned each component is pulverized, and is added in the alcoholic solution of 1 liter 50% (weight), and the dissolving back adds dimethyl sulfoxide 250ml, mix homogeneously obtains acne external medicinal liquid (ProductName: the Cuo beautifying liquid disappears).

Embodiment two: metronidazole 200 grams, chloromycetin 80 grams, diethylstilbestrol 0.6 gram, vitamin B6 8 grams, above-mentioned each component is ground into powder, be added in the alcoholic solution of 1 liter 60% (weight), the dissolving back adds dimethyl sulfoxide 500ml, and mix homogeneously obtains acne external medicinal liquid (ProductName: the Cuo beautifying liquid disappears).

Embodiment three: metronidazole 250 grams, chloromycetin 100 grams, diethylstilbestrol 1.0 gram vitamin Bies 10 grams, with above-mentioned each component pulverize, join in the alcoholic solution of 1 liter 70% (weight), the dissolving back adds dimethyl sulfoxide 800ml, and mix homogeneously obtains acne external medicinal liquid (ProductName: the Cuo beautifying liquid disappears).

Use various acne vulgaris 169 examples of external medicinal liquid of the present invention (the Cuo beautifying liquid disappears) treatment, wherein 61 examples of complete data are included statistical analysis in, papular type 22 examples, abscess type 11 examples, nodular type 27 examples, aggretion type 1 example, but pimple, pustule, three kinds of skin lesion of tuberosity often exist simultaneously.Majority used other drug invalid in these cases, as tetracycline for oral administration, minocycline, metronidazole, enlightening dimension capsule, zinc preparation, external acne Herba Senecionis Dianthui, chlorine willow tincture, Benzoyl Peroxide, retinoic acid frost, sulfur cream, French acne ointment, skin are scorching peaceful etc.Curative effect: 57 examples of fully recovering (93.44%), wherein 1 example is an acne conglobata, produce effects 3 examples (4.9%), effective 1 example (1.63%), total effective rate 100% has 2 examples to fail to continue treatment because of contact dermatitis occurring, does not include statistical analysis in.The recovery from illness average course of treatment: papular type is 41.7 days, and pustule type is 56.3 days, and nodular type is 88.75 days, and aggretion type (1 example) is 101 days.Select now that to use the disappear model case of Cuo beautifying liquid treatment of the present invention as follows:

Example 1: Chen, the woman, 18 years old, the workman, 96.8.14. examines.Forehead, face have measles, itch February slightly sometimes, and menstruation erythra the last week increases.Dermatological department is checked: forehead, face, buccal are dispersed in that syringe needle is big, the grain of rice is big, the big kermesinus pimple of Semen phaseoli radiati, are many with facial rash.Diagnosis: acne papulosa.Treatment: the external Cuo beautifying liquid that disappears.Curative effect: treat 80 days, deflorescence, stay several light red mottles: skin is delicate before than treatment.Recovery from illness.

Example 2: blue certain, the woman, 37 years old, the cadre, 97.4.10. examines.Face has pimple, pustule, pain March slightly.Other hospitals add quiet of dexamethasone for 5% glucose saline, compound Salviae Miltiorrhizae, oral vitamin B2, B6, and tetracycline, spironolactone, inositol niacinate and Chinese medicine, the externally used antimicrobial medicinal liquid, treatment is not good January.Dermatological department is checked: facial, lower jaw is dispersed in syringe needle, Semen phaseoli radiati large red pimple, and blush has the minority pustule on every side, and left facial part, lower-left jaw respectively have a red tuberosity.Diagnosis: papulopustule acne nodosum.Treatment: the external Cuo beautifying liquid that disappears.Curative effect: treated 90 days, shallow brown patch point is stayed in deflorescence, and skin is preceding more delicate than treatment.Recovery from illness.

Example 3: Teng, the man, 19 years old, the university students, 97.7.6. examines.Forehead, neck, the back of the body have pimple, pustule 4 years.External Radix Scutellariae, Rhizoma Coptidis, the beautiful skin dew of rainwater, fancy soap for moistening skin, sulfur fancy soap are not good.Dermatological department is checked: forehead, geisoma, face, the back of the body, buccal are dispersed in that syringe needle is big, Semen phaseoli radiati large red pimple, and maximum with facial rash, left facial part has red patch and 2 red tuberositys of soaking into.Diagnosis: papulonodule acne.Treatment: the external Cuo beautifying liquid that disappears.Curative effect: treated 116 days, skin lesion disappears, and stays light brown speckle, and skin treatment is preceding delicate.Recovery from illness.

Example 4: Liao, the woman, 30 years old, the workman, 96.6.28. examines.Face has pimple, pustule to itch slightly 10 years.Vitamin B6 for oral administration, B2, Chinese medicine face beautiful face, LIUWEI DIHUANG WAN, the beautiful skin of external rainwater reveals, and laser irradiation is not good.Dermatological department is checked: forehead, face are dispersed in the colour of skin, the big pimple of pale red syringe needle, two eyebrow inboards, the unusual side of right nose, and left angle of mandible has pustule, and respectively there is 1 red tuberosity on buccal and chest right side.Diagnosis: papulopustule acne nodosum.Treatment: an external beautifying liquid that disappears.Curative effect: treated 132 days, skin lesion disappears.Recovery from illness.

Example 5: Lee, the woman, 19 years old, the university students, 96.8.13. examines.Face had erythra 4 years, and erythra increases January.Tetracycline for oral administration, vitamin B2, B6, Chinese medicine, the beautiful skin of external rainwater reveals, and the ginseng-pearl cosmetic cream is not good.Dermatological department is checked: two faces have more kermesinus tuberosity, pustule is arranged on it, behind cheek, the auris dextra, respectively there is 1 red tuberosity the neck both sides, two faces respectively have a slice kermesinus to soak into speckle, there is pustule at nodosity, edge on it, left facial part has 1 abscess, pustule is arranged on it, forehead, the two eyebrows outside is dispersed in red pimple, there are a plurality of red pimples, pustule in the buccal.Face has a plurality of recessed cicatrixes.Diagnosis: acne conglobata.Treatment: the external Cuo beautifying liquid that disappears.Curative effect: treated 101 days, skin lesion disappears, and skin treatment is preceding delicate.Recovery from illness.

Example 6: Lin, the woman, 22 years old, the workman, 97.2.3. examines.Face had erythra 4 years, and erythra increased in nearly 3 months, and pustule is arranged sometimes, the pain of itching slightly.When working in the Dongguan, Guangdong, local hospital is taken medicine, the injection clindamycin, and external-applied ointment is not good.Dermexanthesis is relevant with menstruation.Dermatological department is checked: two faces have Semen phaseoli radiati big, the big kermesinus tuberosity of Semen Glycines, syringe needle large red pimple, pustule is arranged, left eyebrow inside front, the right eyebrow outside on it, left facial part, buccal all have the big kermesinus tuberosity of 1 * 1cm2, and forehead, skin of upper lip are dispersed in that syringe needle is big, the big kermesinus pimple of the grain of rice.Diagnosis: papulopustule acne nodosum.Treatment: the external Cuo beautifying liquid that disappears.Curative effect: treated 83 days, skin lesion disappears, and stays light brown, pale red speckle, and skin treatment is preceding delicate.Recovery from illness.

The result shows from clinical practice: the present invention's Cuo beautifying liquid that disappears adopts antibacterium, fungus and androgen antagonist medicine drug combination and penetrating agent skin permeation to discharge the effect of medicine by force, rapidly, obtain significant curative effect, cure rate is up to 93.44%, total effective rate 100%, recovery from illness back skin treatment is preceding delicate.The obstinate refractory of acne conglobata use antibiotics to its treatment in general, injection 17-hydroxy-11-dehydrocorticosterone and superficial X-ray irradiation in the 17-hydroxy-11-dehydrocorticosterone, skin lesion, and external used medicine healing polymerism Cuo trace separately, and domestic still do not have a report.This medicinal liquid has effect comprehensively, determined curative effect, and the cure rate height, avirulence, untoward reaction is few, and external is convenient, is easy to preparation.

Claims (2)

1, a kind of external medicinal liquid for the treatment of acne, the composition and the weight content that it is characterized in that said composition comprise: metronidazole 100-250 gram, chloromycetin 50-100 gram, diethylstilbestrol 0.5-1.0 gram, vitamin B6 2-10 gram, 1000 milliliters of the ethanol of weight concentration 50-70%, dimethyl sulfoxide 200-800 milliliter.

2, a kind of preparation method of external medicinal liquid of treatment acne as claimed in claim, it is characterized in that elder generation with metronidazole, chloromycetin, diethylstilbestrol, vitamin B6 pulverize, is added in the alcoholic solution, after the dissolving, add dimethyl sulfoxide again, obtain product behind the mix homogeneously.